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H3F3A_ENST00000366816 ,H3-3B ,P84243
  • Uniprot Accession= P84243
  • Ensembl Transcript= ENST00000366816.5
  • Uniprot Name= H3-3B
  • Name= Histone H3.3
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 88
GO term
GO name
GO namespace
GO def
GO:0005654 nucleoplasm cellular_component That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
GO:0000228 nuclear chromosome cellular_component A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact. [GOC:dph, GOC:mah]
GO:0044087 regulation of cellular component biogenesis biological_process Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. [GOC:jl]
GO:0008283 cell population proliferation biological_process The multiplication or reproduction of cells, resulting in the expansion of a cell population. [GOC:mah, GOC:mb]
GO:0031491 nucleosome binding molecular_function Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. [GOC:mah]
GO:0010605 negative regulation of macromolecule metabolic process biological_process Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. [GOC:dph, GOC:tb]
GO:0048589 developmental growth biological_process The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another. [GOC:go_curators]
GO:0031497 chromatin assembly biological_process The assembly of DNA, histone proteins, other associated proteins, and sometimes RNA, into chromatin structure, beginning with the formation of the basic unit, the nucleosome, followed by organization of the nucleosomes into higher order structures, ultimately giving rise to a complex organization of specific domains within the nucleus. [http://www.infobiogen.fr/services/chromcancer/IntroItems/ChromatinEducEng.html, PMID:20404130]
GO:0030307 positive regulation of cell growth biological_process Any process that activates or increases the frequency, rate, extent or direction of cell growth. [GOC:go_curators]
GO:0033044 regulation of chromosome organization biological_process Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome. [GOC:mah]
GO:0050789 regulation of biological process biological_process Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. [GOC:ai, GOC:go_curators]
GO:0010639 negative regulation of organelle organization biological_process Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. [GOC:dph, GOC:tb]
GO:0000976 transcription cis-regulatory region binding molecular_function Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. [GOC:txnOH]
GO:0006325 chromatin organization biological_process Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin. [GOC:mah, GOC:vw, PMID:20404130]
GO:0043226 organelle cellular_component Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane. [GOC:go_curators]
GO:0007281 germ cell development biological_process The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism. [GOC:go_curators]
GO:0032501 multicellular organismal process biological_process Any biological process, occurring at the level of a multicellular organism, pertinent to its function. [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]
GO:0008584 male gonad development biological_process The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure. [GOC:jid]
GO:0043565 sequence-specific DNA binding molecular_function Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. [GOC:jl]
GO:0032502 developmental process biological_process A biological process whose specific outcome is the progression of an integrated living unit
GO:0031507 heterochromatin assembly biological_process An epigenetic gene silencing mechanism that involves the assembly of chromatin into heterochromatin, resulting in a chromatin conformation refractory to transcription. This process starts with heterochromatin nucleation, its spreading, and ends with heterochromatin boundary formation. [GOC:mah, PMID:25192661, PMID:33827924]
GO:0110165 cellular anatomical entity cellular_component A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex. [GOC:kmv]
GO:0031490 chromatin DNA binding molecular_function Binding to DNA that is assembled into chromatin. [GOC:mah]
GO:0033043 regulation of organelle organization biological_process Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. [GOC:mah]
GO:0003676 nucleic acid binding molecular_function Binding to a nucleic acid. [GOC:jl]
GO:0048468 cell development biological_process The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. [GOC:go_curators]
GO:0010468 regulation of gene expression biological_process Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018]
GO:0048609 multicellular organismal reproductive process biological_process The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs. [GOC:dph, GOC:jid, GOC:tb]
GO:0051128 regulation of cellular component organization biological_process Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. [GOC:ai]
GO:0048856 anatomical structure development biological_process The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. [GO_REF:0000021]
GO:0030154 cell differentiation biological_process The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. [ISBN:0198506732]
GO:0019222 regulation of metabolic process biological_process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. [GOC:go_curators]
GO:1990837 sequence-specific double-stranded DNA binding molecular_function Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding. [GOC:dos, GOC:sl]
GO:0050794 regulation of cellular process biological_process Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. [GOC:go_curators]
GO:0070828 heterochromatin organization biological_process Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin, a compact and highly condensed form of chromatin. [GOC:mah]
GO:0051129 negative regulation of cellular component organization biological_process Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. [GOC:ai]
GO:0032991 protein-containing complex cellular_component A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. [GOC:dos, GOC:mah]
GO:0060255 regulation of macromolecule metabolic process biological_process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. [GOC:dph, GOC:tb]
GO:0065007 biological regulation biological_process Any process that modulates a measurable attribute of any biological process, quality or function. [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]
GO:0006338 chromatin remodeling biological_process Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation. [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]
GO:0022412 cellular process involved in reproduction in multicellular organism biological_process A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism. [GOC:isa_complete]
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding molecular_function Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II. [GOC:txnOH]
GO:0048519 negative regulation of biological process biological_process Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. [GOC:jid]
GO:0043229 intracellular organelle cellular_component Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. [GOC:go_curators]
GO:0009987 cellular process biological_process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. [GOC:go_curators, GOC:isa_complete]
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0006333 chromatin assembly or disassembly biological_process The formation or destruction of chromatin structures. [GOC:mah]
GO:0032200 telomere organization biological_process A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins. [GOC:dph, GOC:jl, GOC:mah]
GO:0031982 vesicle cellular_component Any small, fluid-filled, spherical organelle enclosed by membrane. [GOC:mah, GOC:pz, GOC:vesicles]
GO:0048869 cellular developmental process biological_process A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition. [GOC:isa_complete]
GO:0005634 nucleus cellular_component A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
GO:0040007 growth biological_process The increase in size or mass of an entire organism, a part of an organism or a cell. [GOC:bf, GOC:ma]
GO:0032993 protein-DNA complex cellular_component A macromolecular complex containing both protein and DNA molecules. [GOC:mah]
GO:0043227 membrane-bounded organelle cellular_component Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators]
GO:0001046 core promoter sequence-specific DNA binding molecular_function Binding to a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon. [GOC:pg, GOC:txnOH]
GO:0003677 DNA binding molecular_function Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
GO:0044877 protein-containing complex binding molecular_function Binding to a macromolecular complex. [GOC:jl]
GO:0007338 single fertilization biological_process The union of male and female gametes to form a zygote. [GOC:ems, GOC:mtg_sensu]
GO:0042692 muscle cell differentiation biological_process The process in which a relatively unspecialized cell acquires specialized features of a muscle cell. [CL:0000187, GOC:go_curators]
GO:2001251 negative regulation of chromosome organization biological_process Any process that stops, prevents or reduces the frequency, rate or extent of chromosome organization. [GOC:obol]
GO:0010629 negative regulation of gene expression biological_process Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018]
GO:0000781 chromosome, telomeric region cellular_component The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres). [GOC:elh]
GO:0003690 double-stranded DNA binding molecular_function Binding to double-stranded DNA. [GOC:elh, GOC:vw]
GO:0009892 negative regulation of metabolic process biological_process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. [GOC:go_curators]
GO:0007286 spermatid development biological_process The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure. [GOC:dph, GOC:go_curators]
GO:0005576 extracellular region cellular_component The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
GO:0006997 nucleus organization biological_process A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus. [GOC:dph, GOC:ems, GOC:jl, GOC:mah]
GO:1901363 heterocyclic compound binding molecular_function Binding to heterocyclic compound. [GOC:TermGenie]
GO:0048523 negative regulation of cellular process biological_process Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. [GOC:jid]
GO:0003006 developmental process involved in reproduction biological_process A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring. [GOC:dph, GOC:isa_complete]
GO:0005694 chromosome cellular_component A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. [ISBN:0198547684]
GO:0016043 cellular component organization biological_process A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. [GOC:ai, GOC:jl, GOC:mah]
GO:0040029 regulation of gene expression, epigenetic biological_process A process that modulates the frequency, rate or extent of gene expression by remodelling of chromatin by either modifying the chromatin fiber, the nucleosomal histones, or the DNA. Once established, this regulation may be maintained over many cell divisions. It can also be heritable in the absence of the instigating signal. [PMID:10521337, PMID:11498582, PMID:22243696, PMID:34414474]
GO:0043232 intracellular non-membrane-bounded organelle cellular_component Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes. [GOC:go_curators]
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding molecular_function Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. [GOC:txnOH-2018]
GO:0006334 nucleosome assembly biological_process The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. [GOC:mah]
GO:0007276 gamete generation biological_process The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell. [GOC:ems, GOC:mtg_sensu]
GO:0034724 DNA replication-independent chromatin organization biological_process The formation or destruction of chromatin structures, occurring outside the context of DNA replication. [GOC:mah, PMID:17510629]
GO:0043228 non-membrane-bounded organelle cellular_component Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes. [GOC:go_curators]
GO:0005488 binding molecular_function The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. [GOC:ceb, GOC:mah, ISBN:0198506732]
GO:0043254 regulation of protein-containing complex assembly biological_process Any process that modulates the frequency, rate or extent of protein complex assembly. [GOC:jl]
GO:0022414 reproductive process biological_process A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents. [GOC:dph, GOC:isa_complete]
GO:0097159 organic cyclic compound binding molecular_function Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure. [GOC:sjw, PMID:7583672]
GO:0022607 cellular component assembly biological_process The aggregation, arrangement and bonding together of a cellular component. [GOC:isa_complete]
GO:0071840 cellular component organization or biogenesis biological_process A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component. [GOC:mah]
GO:0001067 transcription regulatory region nucleic acid binding molecular_function Binding to a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair. [GOC:txnOH]
GO:0003682 chromatin binding molecular_function Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. [GOC:jl, ISBN:0198506732, PMID:20404130]
GO:0045814 negative regulation of gene expression, epigenetic biological_process An epigenetic process that stops, prevents or reduces the rate of gene expression by remodelling of chromatin by either modifying the chromatin fiber, the nucleosomal histones, or the DNA. [PMID:22243696]