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Genome-wide TSV / FASTA tables and pre-built mutation × region joins. For REST, live try-it, Python examples, and JSON layer names, open API.

Open API

Annotation layers & methods

Aligned with Summary, Visual, and Browse (colour keys)

These tables are the same evidence you see as tracks and columns in Summary and Browse; colours are aligned across the portal.

Disorder & structure

IUPred / combined disorder MobiDB experimental AlphaFold PDB

Domains, motifs & sites

Pfam ELM PEM core motifs ScanSite MFIB DIBS PhasePro

Variants (merged tables + disease)

TCGA COSMIC cBioPortal ClinVar OMIM

Pathogenicity & downloads

In silico pathogenicity scores (same predictor table as in downloads); somatic mutation layers in TCGA / COSMIC / cBioPortal tabs. For machine-readable field names and programmatic access, see API → Annotation keys.

Bulk downloads

Genome-wide TSV and FASTA tables

Choose a category to see its files and a sample of the real on-disk format. For single-protein tables (full annotation per protein), use the download control on the Summary page, or fetch the same slices via REST on the API page.

One sequence per protein (FASTA) or a wide protein table (TSV) with accessions, gene names, UniProt IDs, transcripts, and other core columns.

Sample from static/download/ (first lines)

— Proteins.tsv —
Protein ID	UniProt Accession	Transcript ID	Gene Name	Name	Chromosome	Cancer Driver
THUMPD1-203	Q9NXG2	ENST00000565248.1	THUMPD1	THUMP domain-containing protein 1	chr16	Not Cancer Driver
THUMPD1-206	Q9NXG2	ENST00000636554.1	THUMPD1	THUMP domain-containing protein 1	chr16	Not Cancer Driver
THUMPD2-201	Q9BTF0	ENST00000378727.8	THUMPD2	THUMP domain-containing protein 2	chr2	Not Cancer Driver
THUMPD2-204	Q9BTF0	ENST00000505747.6	THUMPD2	THUMP domain-containing protein 2	chr2	Not Cancer Driver
THY1-202	P04216	ENST00000524659.1	THY1	Thy-1 membrane glycoprotein	chr11	Not Cancer Driver
THY1-203	P04216	ENST00000524970.5	THY1	Thy-1 membrane glycoprotein	chr11	Not Cancer Driver

Proteins.fastaAll protein sequences Proteins.tsvMaster protein table

Exon boundaries and PhastCons-style conservation tracks aligned to protein coordinates.

Sample from static/download/

— Exonborder.tsv —
Protein ID	Exon borders
A1BG-201	"0 0 11
1 12 23
2 24 113
3 114 204
4 205 303
5 304 397

— Conservation_phastCons.tsv —
Protein ID	Conservation Scores
A1BG-201	0.0005 ,0.0 ,0.0 ,0.0 ,0.0 ,0.0 ,0.134 ,0.292 ,0.8165 ,0.9424999999999999 ,0.9795 ,0.9844999999999999 ,0.2355 ,0.0005 ,0.0 ,0.0 ,0.0945 ,0.0005 ,0.0 ,0.0 ,0.29100000000000004 ,0.0 ,0.0 ,0.0 ,0.0 ,0.0005 ,0.0035 ,0.0 ,0.014 ,0.0 ,0.0195 ,0.0 ,0.004 ,0.5465 ,0.27149999999999996 ,0.0 ,0.001 ,0.0015 ,0.0 ,0.0 ,0.063 ,0.0 ,0.0015 ,0.0 ,0.0005 ,0.0 ,0.033 ,0.0 ,0.0025 ,0.0 ,0.0005 ,0.0 ,0.0 ,0.0 ,0.002 ,0.0 ,0.0 ,0.0 ,0.0 ,0.0 ,0.0 ,0.0 ,0.10899999999999999 ,0.502 ,0.0 ,0.0 ,0.0 ,0.0 ,0.0 ,0.0055 ,0.0005 ,0.0 ,0.0 ,0.0 ,0.0 ,0.0 ,0.0 ,0.004 ,0.002 ,0.0 ,0.013000000000000001 ,0.001 ,0.064 ,0.159 ,0.0 ,0.002 ,0.008 ,0.002 ,0.0005 ,0.0 ,0.001 ,0.0 ,0.391 ,0.172 ,0.0 ,0.0 ,0.0 ,0.0 ,0.0 ,0.0 ,0.4315 ,0.319 ,0.0 ,0.0 ,0.0 ,0.0 ,0.008 ,0.0125 ,0.08149999999999999 ,0.001 ,0.0055 ,0.002 ,0.28 ,0.333 ,0.052000000000000005 ,0.1255 ,0.0 ,0.0 ,0.4205 ,0.0055 ,0.9924999999999999 ,0.9955 ,0.0 ,0.0 ,0.0045000000000000005 ,0.614 ,0.9884999999999999 ,0.993 ,0.0975 ,0.016 ,0.001 ,0.0 ,0.0005 ,0.0 ,0.0005 ,0.0 ,0.001 ,0.0 ,0.001 ,0.0005 ,0.0 ,0.0 ,0.0 ,0.0255 ,0.005 ,0.0 ,0.10400000000000001 ,0.0225 ,0.001 ,0.091 ,0.026 ,0.009 ,0.001 ,0.0015 ,0.0 ,0.0 ,0.0 ,0.0 ,0.0 ,0.0 ,0.0 ,0.0 ,0.0005 ,0.0 ,0.0 ,0.0 ,0.0 ,0.0 ,0.0135 ,0.023 ,0.0115 ,0.3385 ,0.0015 ,0.274 ,0.3655 ,0.001 ,0.0015 ,0.0 ,0.0615 ,0.133 ,0.9724999999999999 ,0.855 ,0.0105 ,0.0655 ,0.0 ,0.0 ,0.0005 ,0.0 ,0.0195 ,0.0015 ,0.0 ,0.020999999999999998 ,0.7215 ,0.011000000000000001 ,0.9585 ,0.9590000000000001 ,0.0 ,0.0525 ,0.22849999999999998 ,0.0005 ,0.0005 ,0.001 ,0.001 ,0.0015 ,0.07100000000000001 ,0.0 ,0.010499999999999999 ,0.001 ,0.002 ,0.0065 ,0.0 ,0.0 ,0.0 ,0.0 ,0.0 ,0.0 ,0.0 ,0.0 ,0.004 ,0.0 ,0.043 ,0.06 ,0.0 ,0.0 ,0.0045000000000000005 ,0.0 ,0.0 ,0.0 ,0.0 ,0.0 ,0.0 ,0.0235 ,0.0015 ,0.003 ,0.044 ,0.0005 ,0.0 ,0.0 ,0.0005 ,0.0 ,0.965 ,0.0335 ,0.0 ,0.0 ,0.0005 ,0.0025 ,0.0005 ,0.0 ,0.0 ,0.228 ,0.23 ,0.0 ,0.0 ,0.0 ,0.0 ,0.0 ,0.0005 ,0.042499999999999996 ,0.6214999999999999 ,0.02 ,0.0 ,0.0005 ,0.0 ,0.0 ,0.0 ,0.002 ,0.0 ,0.0 ,0.0 ,0.0 ,0.0005 ,0.0 ,0.0 ,0.0 ,0.0015 ,0.0 ,0.119 ,0.062 ,0.29700000000000004 ,0.991 ,0.994 ,0.3205 ,0.0045000000000000005 ,0.0 ,0.0 ,0.0 ,0.0 ,0.0 ,0.0 ,0.0 ,0.00
…

Exonborder.tsv Conservation_phastCons.tsv

Low-complexity and repeat annotations (SEG, DUST, TRF).

Sample from static/download/

— ComplexitySeg.tsv —
Protein ID	Start	End
AADACL2-202	2	14
AADACL2-201	2	14
ACE2-206	2	11
ACE2-201	2	11
ADGRA2-202	2	36
ARHGEF2-221	2	8

— ComplexityDust.tsv —
Protein ID	Start	End
UBE2J2-211	2	23
ACAP3-202	2	27
FNDC10-201	2	75
CAMTA1-201	2	22

— ComplexityTrf.tsv —
Protein ID	Start	End
MS4A7-208	1	1
MS4A7-201	1	1
IRF8-212	1	1
PLCB1-203	1	1

ComplexitySeg.tsv ComplexityDust.tsv ComplexityTrf.tsv

Germline polymorphism, disease tracks (OMIM, ClinVar), and dbNSFP-style pathogenicity scores per variant.

Sample from static/download/

— Polymorphism.tsv —
Protein ID	Mutation	Position	Type

— OMIM_Disease.tsv —
Protein ID	Mutation	Position	Disease	dbSNP	FTId

— ClinVar.tsv —
Protein ID	Position	Mutation	Disease	ClinicalSignificance	RCVaccession	dbSNP	MIMID
ACSF3-212	1	M1V	combined malonic and methylmalonic acidemia	Uncertain	RCV000185752|RCV002282016	370382601	614265
ACSF3-219	1	M1V	combined malonic and methylmalonic acidemia	Uncertain	RCV000185752|RCV002282016	370382601	614265
ACVR1-204	1	M1V	-	Uncertain	RCV003084149		nan
ACVR1-218	1	M1V	-	Uncertain	RCV003084149		nan

— PathogenicityPredictors.tsv —
Protein ID	Position	protein_variant	AlphaMissense	ClinPred	ESM1b	EVE	Polyphen2_HDIV	Polyphen2_HVAR	PrimateAI	SIFT	VARITY_ER_LOO	VARITY_R_LOO	gMVP

Polymorphism.tsv OMIM_Disease.tsv ClinVar.tsv PathogenicityPredictors.tsvdbNSFP predictors + AlphaMissense (missense)

PDB links and Pfam domain intervals.

Sample from static/download/

— PDB.tsv —
Protein ID	PDBs
AARS1-201	4XEOA 0 dis 0 2 1   99,4XEOA 1 ord 3 82 1   99,4XEOA 2 dis 83 83 1   99,4XEOA 3 ord 84 387 1   99,4XEOA 4 dis 388 454 1   99,4XEMA 0 dis 0 2 1   99,4XEMA 1 ord 3 78 1   99,4XEMA 2 dis 79 82 1   99,4XEMA 3 ord 83 384 1   99,4XEMA 4 dis 385 454 1   99,5V59A 0 dis 0 2 1   99,5V59A 1 ord 3 79 1   99,5V59A 2 dis 80 81 1   99,5V59A 3 ord 82 384 1   99,5V59A 4 dis 385 454 1   99,4XEOB 0 dis 0 1 1   99,4XEOB 1 ord 2 77 1   99,4XEOB 2 dis 78 82 1   99,4XEOB 3 ord 83 385 1   99,4XEOB 4 dis 386 454 1   99,5KNNH 0 ord 3 448 1  100,5KNNH 1 dis 449 452 1  100,5KNNG 0 ord 3 451 1  100,5KNNG 1 dis 452 452 1  100,5KNNF 0 ord 3 451 1  100,5KNNF 1 dis 452 452 1  100,5KNNE 0 ord 3 452 1  100,5KNND 0 ord 3 449 1  100,5KNND 1 dis 450 452 1  100,5KNNC 0 ord 3 446 1  100,5KNNC 1 dis 447 452 1  100,5KNNB 0 ord 3 452 1  100,5KNNA 0 ord 3 452 1  100,5T76A 0 dis 756 756 1   99,5T76A 1 ord 757 964 1   99,5T5SA 0 dis 756 756 1   99,5T5SA 1 ord 757 963 1   99,5T5SA 2 dis 964 964 1   99
AAMDC-206	2Q4QB 0 ord 1 36 1  100,2Q4QB 1 dis 37 46 1  100,2Q4QB 2 ord 47 121 1  100,2Q4QA 0 ord 1 121 1  100,2AB1B 0 ord 1 36 1  100,2AB1B 1 dis 37 46 1  100,2AB1B 2 ord 47 121 1  100,2AB1A 0 ord 1 121 1  100
A2M-201	6TAVD 0 dis 0 25 1  100,6TAVD 1 ord 26 689 1  100,6TAVD 2 dis 690 728 1  100,6TAVD 3 ord 729 1335 1  100,6TAVD 4 dis 1336 1473 1  100,6TAVC 0 dis 0 26 1  100,6TAVC 1 ord 27 690 1  100,6TAVC 2 dis 691 726 1  100,6TAVC 3 ord 727 1336 1  100,6TAVC 4 dis 1337 1473 1  100,6TAVB 0 dis 0 26 1  100,6TAVB 1 ord 27 688 1  100,6TAVB 2 dis 689 727 1  100,6TAVB 3 ord 728 1338 1  100,6TAVB 4 dis 1339 1473 1  100,6TAVA 0 dis 0 23 1  100,6TAVA 1 ord 24 699 1  100,6TAVA 2 dis 700 727 1  100,6TAVA 3 ord 728 1467 1  100,6TAVA 4 dis 1468 1473 1  100,4ACQD 0 dis 23 25 0   99,4ACQD 1 ord 26 688 0   99,4ACQD 2 dis 689 727 0   99,4ACQD 3 ord 728 1334 0   99,4ACQD 4 dis 1335 1473 0   99,4ACQC 0 dis 23 25 0   99,4ACQC 1 ord 26 688 0   99,4ACQC 2 dis 689 727 0   99,4ACQC 3 ord 728 1467 0   99,4ACQC 4 dis 1468 1473 0   99,4ACQB 0 dis 23 25 0   99,4ACQB 1 ord 26 688 0   99,4ACQB 2 dis 689 727 0   99,4ACQB 3 ord 728 1334 0   99,4ACQB 4 dis 1335 1473 0   99,4ACQA 0 dis 23 25 0   99,4ACQA 1 ord 26 688
…

— Pfam.tsv —
Protein ID	alignment_start	alignment_end	envelope_start	envelope_end	hmm_acc	hmm_name	type	hmm_start	hmm_end	hmm_length	bit_score	e_value	significance	clan
ACRBP-204	1	240	1	240	PF07222.15	PBP_sp32	Family	1	240	240	537.2	3.9e-162	1.0	-
ACRBP-201	1	240	1	240	PF07222.15	PBP_sp32	Family	1	240	240	535.1	1.7e-161	1.0	-
ACRBP-203	1	88	1	97	PF07222.15	PBP_sp32	Family	1	88	240	188.7	1.1e-55	1.0	-
ATE1-218	1	56	1	56	PF04376.16	ATE_N	Family	26	81	81	91.0	5.1e-26	1.0	-

— Disordered_PDB_regions.tsv —
accession	gene_name	chromosome	dataset	region_identifier	start	end	source_db	category	count_total	count_disordered	count_ordered	disorder_combined
A2M-201	A2M	chr12	Disordered+PDB	6TAVD (1–23)	1	23	TCGA	Cancer	2	2	0	1.0
A2M-201	A2M	chr12	Disordered+PDB	6TAVC (1–23)	1	23	TCGA	Cancer	2	2	0	1.0
A2M-201	A2M	chr12	Disordered+PDB	6TAVB (1–23)	1	23	TCGA	Cancer	2	2	0	1.0
A2M-201	A2M	chr12	Disordered+PDB	6TAVA (1–23)	1	23	TCGA	Cancer	2	2	0	1.0

PDB.tsv Disordered_PDB_regions.tsv Pfam.tsv

Disorder (IUPred, Anchor, MobiDB), AIUPred binding propensity vectors, and AlphaFold-related fields.

Sample from static/download/

— IUPred.tsv —
Protein ID	IUPred scores
A1BG-201	0.7433, 0.7428, 0.777, 0.7683, 0.7522, 0.7736, 0.7775, 0.7746, 0.774, 0.7623, 0.7515, 0.7179, 0.7061, 0.642, 0.6314, 0.5729, 0.6053, 0.5878, 0.5739, 0.565, 0.5568, 0.5355, 0.5245, 0.5066, 0.4953, 0.4858, 0.464, 0.4505, 0.4499, 0.4321, 0.3966, 0.3726, 0.3669, 0.3668, 0.3645, 0.3585, 0.3796, 0.3705, 0.3654, 0.3591, 0.3483, 0.343, 0.3365, 0.3607, 0.3731, 0.3823, 0.363, 0.3703, 0.3478, 0.3319, 0.3343, 0.347, 0.3348, 0.3348, 0.343, 0.3498, 0.3468, 0.3633, 0.3758, 0.4063, 0.4055, 0.4195, 0.4242, 0.4242, 0.4223, 0.4172, 0.4166, 0.4163, 0.4146, 0.4052, 0.4071, 0.3923, 0.4013, 0.3924, 0.3761, 0.3546, 0.3629, 0.3606, 0.3534, 0.3332, 0.3272, 0.3157, 0.316, 0.3052, 0.3034, 0.2896, 0.2941, 0.2902, 0.2845, 0.284, 0.2848, 0.291, 0.2823, 0.2904, 0.3032, 0.2959, 0.2945, 0.302, 0.2972, 0.2978, 0.2918, 0.3007, 0.3223, 0.3374, 0.3301, 0.3477, 0.3459, 0.3509, 0.3557, 0.3568, 0.3582, 0.3727, 0.3793, 0.3787, 0.3746, 0.3911, 0.3866, 0.3821, 0.3832, 0.4054, 0.4117, 0.3978, 0.4103, 0.4102, 0.4022, 0.3925, 0.3596, 0.3158, 0.3291, 0.3039, 0.2906, 0.2952, 0.2896, 0.2974, 0.2838, 0.2581, 0.2567, 0.2503, 0.2448, 0.2462, 0.2533, 0.2635, 0.2729, 0.275, 0.2772, 0.2878, 0.2816, 0.2752, 0.297, 0.2988, 0.3055, 0.3204, 0.3233, 0.3308, 0.3466, 0.3548, 0.3483, 0.3573, 0.3677, 0.3899, 0.4051, 0.4287, 0.4574, 0.4684, 0.4798, 0.4856, 0.481, 0.4856, 0.4859, 0.4843, 0.4784, 0.4754, 0.4713, 0.4728, 0.4821, 0.4796, 0.4596, 0.4557, 0.4504, 0.4119, 0.4222, 0.4243, 0.427, 0.4358, 0.4496, 0.4549, 0.5062, 0.5037, 0.4636, 0.4796, 0.5112, 0.4832, 0.513, 0.4891, 0.5331, 0.5991, 0.6025, 0.6235, 0.624, 0.5982, 0.5607, 0.5567, 0.5503, 0.5473, 0.5286, 0.5221, 0.5256, 0.5082, 0.5179, 0.5093, 0.4658, 0.4666, 0.4727, 0.4614, 0.4522, 0.4305, 0.4359, 0.4439, 0.4098, 0.394, 0.3545, 0.3504, 0.3363, 0.3325, 0.3402, 0.3491, 0.344, 0.3231, 0.3228, 0.3203, 0.3123, 0.2967, 0.3009, 0.2981, 0.3037, 0.3136, 0.3188, 0.3161, 0.3166, 0.3069, 0.313, 0.3221, 0.3407, 0.3438, 0.3508, 0.3577, 0.3649, 0.3677, 0.3752, 0.3729, 0.3701, 0.364, 0.3574, 0.3621, 0.3564, 0.3596, 0.3484, 0.3388, 0.3307, 0.3174, 0.3088, 0.3036, 0.2984, 0.292, 0.2966, 0.2759, 0.2615, 0.251, 0.2421, 0.2309, 0.2338, 0.2264, 0.2307, 0.2399
…

— Anchor.tsv —
Protein ID	Anchor scores
A1BG-201	0.0152, 0.0173, 0.0189, 0.0212, 0.0248, 0.0294, 0.0368, 0.0453, 0.0548, 0.0675, 0.082, 0.0939, 0.103, 0.1155, 0.1214, 0.1235, 0.1242, 0.1191, 0.118, 0.1144, 0.1044, 0.0983, 0.0952, 0.0985, 0.0995, 0.1107, 0.1201, 0.1304, 0.1469, 0.1596, 0.1767, 0.1978, 0.2102, 0.2234, 0.2237, 0.2253, 0.2134, 0.2067, 0.2037, 0.1963, 0.194, 0.1894, 0.1899, 0.1947, 0.1995, 0.2136, 0.2293, 0.2531, 0.2746, 0.2967, 0.3286, 0.354, 0.3799, 0.3966, 0.4141, 0.4317, 0.4184, 0.4097, 0.4097, 0.4043, 0.4056, 0.4176, 0.4231, 0.4269, 0.4257, 0.4265, 0.4323, 0.4334, 0.4322, 0.4333, 0.4333, 0.4249, 0.4142, 0.408, 0.4013, 0.3976, 0.3972, 0.3977, 0.3983, 0.3998, 0.3965, 0.4038, 0.4194, 0.4279, 0.41, 0.3925, 0.3786, 0.3681, 0.3593, 0.3484, 0.3447, 0.3411, 0.3415, 0.3469, 0.3555, 0.3644, 0.3756, 0.3849, 0.3946, 0.4062, 0.4179, 0.4185, 0.4203, 0.4239, 0.4209, 0.421, 0.4219, 0.4174, 0.4114, 0.4088, 0.4051, 0.4024, 0.4115, 0.4197, 0.4293, 0.4201, 0.4086, 0.3936, 0.3745, 0.3558, 0.3442, 0.3375, 0.3269, 0.3282, 0.3311, 0.3364, 0.3461, 0.3515, 0.3649, 0.382, 0.397, 0.4061, 0.4095, 0.4192, 0.4209, 0.4207, 0.4206, 0.4179, 0.4135, 0.4054, 0.3958, 0.3891, 0.384, 0.3828, 0.3774, 0.3726, 0.3698, 0.3635, 0.3601, 0.362, 0.3674, 0.3695, 0.3707, 0.3717, 0.3738, 0.3778, 0.3804, 0.3809, 0.386, 0.3928, 0.3976, 0.3989, 0.4021, 0.4053, 0.409, 0.4114, 0.4151, 0.419, 0.4246, 0.4292, 0.433, 0.4364, 0.4402, 0.4435, 0.445, 0.4454, 0.4461, 0.4469, 0.4483, 0.4523, 0.4548, 0.4611, 0.4679, 0.4779, 0.4864, 0.4993, 0.5146, 0.5245, 0.5357, 0.5417, 0.5462, 0.5464, 0.5416, 0.5396, 0.5393, 0.5412, 0.5416, 0.539, 0.5364, 0.5294, 0.5224, 0.5176, 0.5161, 0.5176, 0.5163, 0.5134, 0.509, 0.5051, 0.5038, 0.4992, 0.4967, 0.4929, 0.4916, 0.4864, 0.4816, 0.4748, 0.4702, 0.4671, 0.465, 0.4658, 0.4665, 0.4655, 0.4602, 0.4549, 0.4522, 0.4496, 0.4483, 0.4471, 0.445, 0.4422, 0.4388, 0.4366, 0.4358, 0.4342, 0.4325, 0.4308, 0.4288, 0.4267, 0.424, 0.421, 0.4162, 0.412, 0.4069, 0.4049, 0.4037, 0.4019, 0.4004, 0.3971, 0.3951, 0.3926, 0.3951, 0.4026, 0.409, 0.4134, 0.4149, 0.4142, 0.4139, 0.4132, 0.4106, 0.4078, 0.4031, 0.3969, 0.3883, 0.3842, 0.3851, 0.3861, 0.3887, 0.3891, 0.3905, 0.394, 0.3977, 0.404, 0.4092, 0.4133, 0
…

— AIUPred_Binding.tsv —
Protein ID	AIUPred binding scores
AADACL2-202	0.1999, 0.1103, 0.1262, 0.1771, 0.0881, 0.1485, 0.1876, 0.1599, 0.252, 0.197, 0.1864, 0.2577, 0.3442, 0.2909, 0.24, 0.1887, 0.1937, 0.1569, 0.2368, 0.1937, 0.1386, 0.1334, 0.2035, 0.197, 0.0852, 0.0852, 0.1294, 0.1543, 0.1752, 0.1485, 0.2423, 0.2035, 0.1262, 0.1543, 0.1703, 0.2577, 0.252, 0.1569, 0.2178, 0.1599, 0.1628, 0.1386, 0.2742, 0.0909, 0.1569, 0.1294, 0.1103, 0.128, 0.1887, 0.2146, 0.1937, 0.1386, 0.1752
AAMDC-205	0.7835, 0.4951, 0.7003, 0.7003, 0.8147, 0.8842, 0.666, 0.6341, 0.8289, 0.7105, 0.856, 0.8877, 0.6142, 0.6766, 0.5688, 0.5902, 0.5771, 0.3148, 0.2361, 0.302, 0.252, 0.2035, 0.5856, 0.7349, 0.7813, 0.8842, 0.7014, 0.4989, 0.8251, 0.3401, 0.3938, 0.4306, 0.3124, 0.6834, 0.3319, 0.8318, 0.5294, 0.8366, 0.6747, 0.6657, 0.1937, 0.2769, 0.1599, 0.3995, 0.1543, 0.1642, 0.1771, 0.1982, 0.2368, 0.2388, 0.2423, 0.1642, 0.2909, 0.4894, 0.3691, 0.4783, 0.3124, 0.5261, 0.3671, 0.2232, 0.3474, 0.2146, 0.197, 0.1599, 0.2315, 0.1982, 0.3319, 0.3671, 0.2885, 0.23, 0.2465, 0.1703, 0.2361, 0.1864, 0.1876, 0.1982, 0.128, 0.1836, 0.1127, 0.128, 0.1642, 0.125, 0.1103, 0.1173, 0.1517, 0.0945, 0.1262, 0.2084, 0.1485, 0.1887, 0.2178, 0.1642, 0.1734
AANAT-204	0.7061, 0.4684, 0.3124, 0.3671, 0.3319, 0.2024, 0.2103, 0.2412, 0.2787, 0.4225, 0.2361, 0.3526, 0.2178, 0.2412, 0.3319, 0.5294, 0.4783, 0.2769, 0.3062, 0.3734, 0.3148, 0.5885, 0.3442, 0.3148, 0.2465, 0.7524, 0.7437, 0.9292, 0.8914, 0.8653, 0.6747, 0.8502, 0.8601, 0.8057, 0.9182, 0.9743, 0.9824, 0.9712, 0.9825, 0.9167, 0.869, 0.9243, 0.9474, 0.9753, 0.8916, 0.9705, 0.9451, 0.8561, 0.9704, 0.9626, 0.9225, 0.9789, 0.9681, 0.9335, 0.8502, 0.6055, 0.6907, 0.8407, 0.9167, 0.6182, 0.7331, 0.7969, 0.9615, 0.8497, 0.9009, 0.9626, 0.8914, 0.9639, 0.9275, 0.9359, 0.9054, 0.8289, 0.7598, 0.6341, 0.513, 0.666, 0.6443, 0.5885, 0.9783, 0.6182, 0.671, 0.7331, 0.7105, 0.9468, 0.777, 0.9739, 0.8497, 0.9612, 0.8626, 0.8631, 0.7892, 0.814
AAMDC-210	0.7813, 0.4951, 0.7014, 0.7197, 0.8191, 0.8842, 0.6747, 0.6443, 0.8318, 0.7014, 0.8545, 0.8916, 0.6182, 0.6834, 0.5902, 0.6033, 0.5856, 0.3598, 0.2412, 0.3319, 0.2742, 0.2262, 0.6033, 0.7506, 0.8242, 0.8631, 0.7267, 0.4532, 0.8407, 0.3671, 0.411
…

— MobiDB.tsv —
Protein ID	Regions	Content Fraction	Content Count
UROD-201	1..10	0.027	10
EPN1-202	1..18	0.031	18
ODC1-201	1..18,422..461	0.126	58
PAX5-201	1..83	0.212	83

— Alphafold.tsv —
Protein ID	PLLDT scores
A1BG-201	41.21, 37.85, 36.99, 32.14, 38.78, 33.06, 34.27, 36.45, 38.16, 34.72, 37.7, 30.96, 37.13, 32.35, 33.03, 30.0, 31.86, 31.81, 32.81, 30.54, 32.18, 32.42, 38.33, 47.55, 56.04, 70.66, 82.94, 89.74, 92.3, 89.64, 91.19, 87.69, 85.26, 77.69, 72.72, 67.96, 62.98, 62.17, 59.83, 63.46, 59.63, 65.93, 63.32, 70.37, 79.84, 88.14, 91.31, 92.4, 93.46, 92.67, 92.32, 88.8, 88.9, 92.15, 93.31, 94.46, 96.26, 97.34, 96.92, 96.37, 95.38, 93.81, 93.78, 93.31, 94.31, 93.7, 93.22, 93.53, 94.88, 95.5, 95.63, 94.47, 93.63, 93.33, 93.83, 94.29, 93.47, 93.71, 94.54, 93.37, 92.42, 88.77, 84.61, 75.55, 76.02, 77.92, 80.97, 84.5, 89.29, 91.97, 93.5, 95.5, 95.66, 96.1, 95.7, 92.7, 87.4, 83.5, 85.5, 90.52, 92.89, 92.98, 91.58, 93.95, 93.27, 87.57, 89.27, 88.96, 87.44, 85.77, 73.16, 67.03, 64.54, 64.63, 71.17, 79.98, 81.72, 87.14, 90.39, 88.73, 92.52, 92.58, 92.46, 91.13, 90.6, 91.87, 92.02, 92.92, 92.77, 90.64, 87.49, 84.92, 88.49, 89.57, 91.06, 94.11, 94.22, 92.07, 91.4, 87.75, 83.58, 80.04, 79.51, 78.82, 77.67, 83.58, 88.08, 91.36, 92.79, 94.39, 94.34, 95.05, 93.14, 89.41, 90.05, 83.45, 84.43, 82.71, 87.26, 85.71, 82.61, 75.16, 65.77, 60.52, 53.27, 54.92, 61.12, 79.35, 86.9, 89.97, 91.26, 93.0, 92.64, 92.53, 89.92, 92.29, 94.5, 94.36, 96.18, 96.11, 95.54, 94.16, 92.86, 89.57, 86.47, 79.89, 72.97, 66.98, 67.57, 70.43, 80.24, 87.14, 88.86, 87.51, 91.63, 92.67, 90.66, 93.28, 93.53, 95.3, 95.56, 94.13, 94.07, 92.7, 89.77, 90.18, 92.12, 93.44, 96.4, 96.9, 95.67, 94.75, 90.72, 84.54, 63.51, 53.97, 43.54, 46.31, 54.76, 68.56, 82.05, 89.3, 90.68, 91.68, 91.61, 91.06, 91.7, 90.1, 92.75, 93.97, 94.88, 95.57, 95.7, 94.51, 92.01, 91.14, 89.65, 85.97, 92.28, 93.05, 95.53, 95.49, 97.54, 97.35, 93.97, 89.25, 88.85, 93.59, 94.94, 95.11, 94.68, 94.02, 95.58, 94.53, 94.31, 91.9, 87.8, 87.25, 88.55, 90.54, 94.3, 95.29, 95.54, 95.54, 94.32, 92.88, 89.31, 91.66, 92.83, 93.51, 92.69, 91.69, 92.4, 90.41, 90.16, 92.75, 95.63, 97.54, 97.31, 96.59, 94.95, 93.14, 89.65, 84.47, 78.83, 72.14, 68.39, 68.3, 83.65, 92.14, 94.43, 92.86, 95.88, 96.87, 94.34, 93.86, 91.83, 91.66, 91.5, 91.34, 92.96, 93.52, 94.18, 94.43, 94.64, 95.92, 95.96, 96.63, 97.14, 97.22, 96.95, 94.53, 92.21, 87.89, 72.3
…

IUPred.tsv Anchor.tsv AIUPred_Binding.tsvPer-residue binding scores MobiDB.tsv Alphafold.tsv

Per-position conservation scores.

Sample from static/download/

— Conservation_Scores.tsv —
Protein ID	Organism Level	Conservation Score
ABCD2-201	Viridiplantae	0.4892320314238502, 0.3214285714285714, 0.3928571428571429, 0.2142857142857143, 0.4892320314238502, 0.2142857142857143, 0.3214285714285714, 0.4285714285714286, 0.4285714285714286, 0.4285714285714286, 0.4285714285714286, 0.4285714285714286, 0.4285714285714286, 0.4285714285714286, 0.4285714285714286, 0.4285714285714286, 0.4285714285714286, 0.4285714285714286, 0.4285714285714286, 0.4285714285714286, 0.1428571428571429, 0.4285714285714286, 0.3571428571428571, 0.4241944196814905, 0.3571428571428571, 0.2857142857142857, 0.4285714285714286, 0.2142857142857143, 0.41544040190161435, 0.41106339301167627, 0.4285714285714286, 0.4285714285714286, 0.5094522323746573, 0.2857142857142857, 0.4285714285714286, 0.4285714285714286, 0.2857142857142857, 0.2857142857142857, 0.7142857142857143, 0.3571428571428571, 0.41544040190161435, 0.4285714285714286, 0.4285714285714286, 0.4285714285714286, 0.4285714285714286, 1.0, 0.4241944196814905, 0.4285714285714286, 0.4285714285714286, 0.2142857142857143, 0.4285714285714286, 0.2857142857142857, 0.3571428571428571, 0.4285714285714286, 0.3571428571428571, 0.41544040190161435, 0.4285714285714286, 0.4285714285714286, 0.4285714285714286, 0.4285714285714286, 0.4285714285714286, 0.4285714285714286, 0.4285714285714286, 0.4285714285714286, 0.4285714285714286, 0.4285714285714286, 0.4285714285714286, 0.4285714285714286, 0.2142857142857143, 0.41544040190161435, 0.3571428571428571, 0.4285714285714286, 0.4285714285714286, 0.1428571428571429, 0.1428571428571429, 0.4285714285714286, 0.3571428571428571, 0.4285714285714286, 0.4285714285714286, 0.2857142857142857, 0.2857142857142857, 0.3571428571428571, 0.4285714285714286, 0.4285714285714286, 0.3571428571428571, 0.1428571428571429, 0.7142857142857143, 0.4285714285714286, 0.3571428571428571, 0.3571428571428571, 0.4285714285714286, 0.4285714285714286, 0.1428571428571429, 1.0, 0.4285714285714286, 0.4241944196814905, 1.0, 0.1428571428571429, 0.2142857142857143, 0.1428571428571429, 0.4285714285714286, 0.4285714285714286, 0.4285714285714286, 0.4285714285714286, 0.5094522323746573, 0.4285714285714286, 0.1428571428571429, 0.4285714285714286, 0.42419441
…

Conservation_Scores.tsv

Somatic mutations: TCGA, legacy TCGA (COSMIC-named files), and cBioPortal.

Sample from static/download/

— TCGA_Missense.tsv —
Protein ID	Phenotype	Mutation	Position	Cancer Type	Cancer Name	Sample ID
ZNF232-212	Missense_Mutation	M1I	1	BLCA	Bladder Urothelial Carcinoma	TCGA-FD-A6TD
ZNF112-202	Missense_Mutation	M1I	1	LUSC	Lung squamous cell carcinoma	TCGA-22-5492
ZNF43-210	Missense_Mutation	M1T	1	STAD	Stomach adenocarcinoma	TCGA-BR-7197

— COSMIC_Missense.tsv —
Protein ID	Phenotype	Mutation	Position	Cancer Type	Cancer Name	Sample ID

— CBioportal_Missense.tsv —
Protein ID	Phenotype	Mutation	Position	Cancer Type	Cancer Name	Sample ID
CASP8-206	Missense_Mutation	M1T	1	LUSC	Lung squamous cell carcinoma	TCGA-37-3792
CASP8-211	Missense_Mutation	M1T	1	LUSC	Lung squamous cell carcinoma	TCGA-37-3792
CASP8-225	Missense_Mutation	M1T	1	LUSC	Lung squamous cell carcinoma	TCGA-37-3792

— CBioportal_Frameshift.tsv —
Protein ID	Phenotype	Mutation	Position	Cancer Type	Cancer Name	Sample ID
ANGPTL8-201	Frame_Shift_Del	M1?	1	LUSC	Lung squamous cell carcinoma	TCGA-77-8133
DCAF8L1-201	Frame_Shift_Del	M1?	1	SKCM	Skin Cutaneous Melanoma	TCGA-W3-AA1R

— CBioportal_Indel.tsv —
Protein ID	Phenotype	Mutation	Position	Cancer Type	Cancer Name	Sample ID
TMEM164-204	del	S2_S3del	2	LUSC	Lung squamous cell carcinoma	TCGA-63-A5ML
TMEM164-202	del	S2_S3del	2	LUSC	Lung squamous cell carcinoma	TCGA-63-A5ML

TCGA_Missense.tsv TCGA_Frameshift.tsv TCGA_Indel.tsv COSMIC_Missense.tsv COSMIC_Frameshift.tsv COSMIC_Indel.tsv CBioportal_Missense.tsv CBioportal_Frameshift.tsv CBioportal_Indel.tsv

ELM motifs, PEM core motifs, ELM switches, and PTM sites (see also disorder / binding tabs for ScanSite and related tracks).

Sample from static/download/

— ELM.tsv —
Protein ID	ELM_Accession	ELMType	ELMIdentifier	Start	End	References	Methods	InstanceLogic	PDB	Organism
ALKBH2-204	ELMI003890	LIG	LIG_PCNA_APIM_2	1	7	19736315 23677613	anti tag coimmunoprecipitation; colocalization; cross linking study; fluorescent resonance energy transfer; isothermal titration calorimetry; western blot	true positive	nan	Homo sapiens
FMNL2-201	ELMI002333	MOD	MOD_NMyristoyl	1	7	20213681	detection by mass spectrometry	true positive	nan	Homo sapiens
RNF157-210	ELMI002332	MOD	MOD_NMyristoyl	1	7	20213681	detection by mass spectrometry	true positive	nan	Homo sapiens
RNF157-201	ELMI002332	MOD	MOD_NMyristoyl	1	7	20213681	detection by mass spectrometry	true positive	nan	Homo sapiens

— ELM_Switches.tsv —
Protein ID	Switch_ID	Status	Interaction_ID	Intramolecular	ID_A	Bindingsite_A_ID	Bindingsite_A_Start	Bindingsite_A_End	ID_B	Bindingsite_B_ID	Bindingsite_B_Start	Bindingsite_B_End	Affected_interactor	Switch_type	Switch_subtype	Switch_mechanism	Switch_direction	Switch_outcome_direction	Switch_outcome	Modification	Modification_sites	Modifying_enzymes	Effector	Cell_cycle_phase	Localisation	Pathway	PMID
CRAT-212	SWTI000472	Active	INTI000574	nan	UNIPROT:P43155	ELM:TRG_MLS	1	21	UNIPROT:O94826	PFAM:PF00515	114	578	ID A	Binary	Pre-translational	Alternative splicing	Irreversible	Negative	Abrogation	nan	nan	nan	nan	nan	nan	nan	PMID:20558530;PMID:7945262
CRAT-201	SWTI000472	Active	INTI000574	nan	UNIPROT:P43155	ELM:TRG_MLS	1	21	UNIPROT:O94826	PFAM:PF00515	114	578	ID A	Binary	Pre-translational	Alternative splicing	Irreversible	Negative	Abrogation	nan	nan	nan	nan	nan	nan	nan	PMID:20558530;PMID:7945262
GLRX2-201	SWTI000570	Active	INTI000673	nan	UNIPROT:Q9NS18	ELM:TRG_MLS	1	21	UNIPROT:O94826	PFAM:PF00515	114	578	ID A	Binary	Pre-translational	Alternative splicing	Irreversible	Negative	Abrogation	nan	nan	nan	nan	nan	nan	nan	PMID:11297543

— PTM.tsv —
Protein ID	Position	Type	Database
STXBP5L-204	1	Acetylation	PTMdb
STIP1-203	1	Acetylation	PTMdb
STXBP5L-207	1	Acetylation	PTMdb
STXBP5L-209	1	Acetylation	PTMdb

ELM.tsv ELM_Switches.tsv PTM.tsv

UniProt-derived regions and binding annotations.

Sample from static/download/

— ROI_UniProt.tsv —
Protein ID	Start	End	Note	Evidence
HOOK1-201	1	555	Sufficient for interaction with microtubules	nan
LRRK2-201	1	969	Required for RAB29-mediated activation	ECO:0000269|PubMed:29212815
ZFYVE27-212	1	92	Sufficient for homooligomerization	ECO:0000269|PubMed:23969831
H2AZ1-201	1	17	Required for interaction with INCENP	ECO:0000250

— Binding_UniProt.tsv —
Protein ID	Position	Note	Evidence
HMGB1-203	1	nan	ECO:0000250|UniProtKB:P10103
FLVCR2-201	1	nan	ECO:0000305|PubMed:32973183
SNCA-205	2	nan	ECO:0000305
HBB-201	2	nan	nan

ROI_UniProt.tsv Binding_UniProt.tsv

Interaction resources (DIBS, MFIB) and binding-domain summaries.

Sample from static/download/

— dibs.tsv —
Protein ID	DIBS_ID	start	end
CXCR4-203	DI1000139	1	38
TP53-202	DI1000009	1	93
TP53-202	DI1000008	1	39
CXCR4-207	DI1000139	1	38

— mfib.tsv —
Protein ID	MFIB_ID	start	end
H4C15-202	MF2200005	1	103
H4C15-202	MF2200007	1	103
H4C14-202	MF2200005	1	103
H4C14-202	MF2200006	1	103

— binding.tsv —
Protein ID	BINDING_ID	start	end
BCL2L1-206	PF02180	1	26
BCL2L1-211	PF02180	1	26
BCL2L1-214	PF02180	1	26
PADI4-201	PF08526	1	111

dibs.tsv mfib.tsv binding.tsv

Phase separation calls from PhasePro.

Sample from static/download/

— phasepro.tsv —
Protein ID	PHASEPRO_ID	start	end
NCK1-211	26553976	1	377
NCK1-210	26553976	1	377
NCK1-207	26553976	1	377
YTHDF3-214	31388144	1	415
YTHDF3-212	31388144	1	415
YTHDF3-213	31388144	1	415

phasepro.tsv

Significantly mutated regions (iSimpre).

Sample from static/download/

— ISimpre_sig_mutated.tsv —
Protein ID	Start	End	Sig Cancer Types	Cancer Types	Method
AASS-203	258	273	SKCM	BRCA, READ, LUAD, LUSC, GBM, SKCM	tcga_isimpre
A2M-201	140	156	SKCM	COAD, STAD, UCEC, SKCM, LUAD, THCA, BLCA	tcga_isimpre
A2M-201	174	176	COAD	BRCA, COAD, UCEC, SKCM, LUAD	tcga_isimpre
ABCA9-201	1359	1416	-	SKCM, BRCA, STAD, UCEC, LUAD, LUSC, PCPG, READ, COAD	tcga_isimpre

ISimpre_sig_mutated.tsv

sciencePer-protein and positional data

Download the full annotation table for one protein from the Summary page, or retrieve the same slices via REST from the API page. Positional exports (.txt / .json) are available from the sequence view on Summary.

Mutation × annotation region tables

Tab-separated joins: ClinVar (all clinical significance classes) + somatic cohort variants overlapping MobiDB, ELM, Pfam, MFIB, DIBS, PhasePro

Each file is tab-separated (UTF-8). One row = one variant whose position falls inside one annotated interval (the same variant may appear on multiple rows if it overlaps several regions). Rows from ClinVar include disease names, clinical significance, and identifiers where available. Rows from somatic cohorts include variant class (missense, frameshift, indel), data source, and tumour / sample context fields.

table_chartColumns (all files)

Column	Meaning
`gencode_accession`	GENCODE protein accession (DisCanVis primary key, links to summary URLs).
`gene_name`	HGNC gene symbol where available.
`uniprot_accession`	UniProt accession on the protein record.
`position`	1-based residue position of the variant on the canonical isoform.
`mutation_aa`	Amino-acid change or variant label as stored (e.g. missense notation).
`variant_origin`	clinvar = ClinVar disease rows; somatic = cohort somatic rows (Mutation* tables: TCGA, COSMIC, cBioPortal, …).
`somatic_variant_class`	missense \| frameshift \| indel for somatic rows; empty for ClinVar.
`somatic_database`	Source label from the somatic record; empty for ClinVar.
`clinical_significance`	ClinVar clinical significance (pathogenic, benign, uncertain, etc.); empty for somatic.
`disease_or_cancer_label`	ClinVar disease name or somatic cancer_name / cohort label.
`sample_or_rcv_id`	ClinVar RCV accession(s) or somatic matchable_sample_id.
`db_snp`	dbSNP rs id when present (ClinVar); empty for somatic in this export.
`region_layer`	experimental_disorder \| elm \| pfam \| mfib \| dibs \| phasepro.
`region_start`	Start of the overlapping annotation interval (1-based, inclusive).
`region_end`	End of the overlapping annotation interval (1-based, inclusive).
`region_feature_id`	Stable id where applicable (ELM accession, Pfam hmm_acc, binding region name).
`region_feature_label`	Human-readable type or name (ELM class\|id, Pfam domain name, binding layer tag).
`extra_note`	Somatic phenotype field when set; otherwise empty.

Preview (first lines)

— mutations_x_experimental_disorder.tsv —
gencode_accession	gene_name	uniprot_accession	position	mutation_aa	variant_origin	somatic_variant_class	somatic_database	clinical_significance	disease_or_cancer_label	sample_or_rcv_id	db_snp	region_layer	region_start	region_end	region_feature_id	region_feature_label	extra_note
ABCC9-201	ABCC9	O60706	665	A665T	clinvar			Benign	dilated cardiomyopathy 1O	RCV000640321|RCV003162879	200891785	experimental_disorder	665	665		MobiDB experimental segment	
ABCC9-202	ABCC9	O60706	665	A665T	clinvar			Benign	dilated cardiomyopathy 1O	RCV000640321|RCV003162879	200891785	experimental_disorder	665	665		MobiDB experimental segment	
ABCC9-215	ABCC9	O60706	665	A665T	clinvar			Benign	dilated cardiomyopathy 1O	RCV000640321|RCV003162879	200891785	experimental_disorder	665	665		MobiDB experimental segment	
ABL1-201	ABL1	P00519	1021	R1021Q	clinvar			Benign	-	RCV002720250		experimental_disorder	1021	1021		MobiDB experimental segment	
ABL1-202	ABL1	P00519	1020	A1020T	clinvar			Uncertain	-	RCV001992307		experimental_disorder	1020	1020		MobiDB experimental segment	
ABL1-202	ABL1	P00519	1020	A1020V	clinvar			Uncertain	-	RCV001768291		experimental_disorder	1020	1020		MobiDB experimental segment	
FANCM-201	FANCM	Q8IYD8	1814	E1814K	clinvar			Uncertain	Fanconi anemia complementation group A	RCV000989214|RCV001061433|RCV001593165	139074680	experimental_disorder	1814	1814		MobiDB experimental segment	
ABCC9-218	ABCC9	O60706	665	A665T	clinvar			Benign	dilated cardiomyopathy 1O	RCV000640321|RCV003162879	200891785	experimental_disorder	665	665		MobiDB experimental segment	
AFF1-201	AFF1	P51825	758	P758Q	clinvar			Uncertain	-	RCV002674519		experimental_disorder	758	758		MobiDB experimental segment	
AFF1-211	AFF1	P51825	758	P758Q	clinvar			Uncertain	-	RCV002674519		experimental_disorder	758	758		MobiDB experimental segment	
AKT1-206	AKT1	P31749	460	T460P	clinvar			Pathogenic	Cowden syndrome 6	RCV000033178	397514645	experimental_disorder	460	460		MobiDB experimental segment

mutations_x_experimental_disorder.tsvVariants overlapping MobiDB experimental disorder segments. · 5741 rows mutations_x_elm.tsvVariants overlapping ELM linear motif instances. · 48667 rows mutations_x_pfam.tsvVariants overlapping Pfam domain alignments. · 3786467 rows mutations_x_mfib.tsvVariants overlapping MFIB intervals. · 11802 rows mutations_x_dibs.tsvVariants overlapping DIBS intervals. · 45475 rows mutations_x_phasepro.tsvVariants overlapping PhasePro regions. · 13727 rows