Help & guided workflows

• DisCanVis (brand) — home page with the main search box and counters.
• Browse (dropdown), grouped for clarity:
  • Proteome — Dynamic Search (custom filters, GO, disorder/motif-related fields); Precompiled tables (classic sortable browser, including chromosome- and GO-oriented views).
  • Disease — OMIM and ClinVar table views.
  • Cancer & networks — Cancer Gene Census (drivers) via Precompiled tables, Dynamic Search, and Significantly mutated regions; PPI network, Mutation / sample.
  For experimental disorder, ELM, PhasePro, and similar annotations, use Dynamic Search or Precompiled tables.
• Search — dedicated protein search page (same backend as the home box): results table, filters, and exports.
• Batch — upload or paste protein/region lists for aggregated tables and charts.
• Docs (dropdown) — Help, About, Use cases, API (REST and try-it). Statistics — proteome dashboards. Downloads — bulk files and mutation×region tables.
• Theme — sun/moon toggle; your choice is remembered in this browser.
• On most pages (except Home and Search), the navbar includes a compact quick gene search field with autocomplete — same pipeline as the home search.

Use Search (menu item), the home search box, or the navbar quick gene search (where shown). Accepted identifiers include gene symbols, UniProt accessions, Ensembl transcript IDs, and related text fields. Toggle main isoforms only to restrict to canonical isoforms.

Submitting the search opens the search results page: a DataTables-style table with column filtering, pagination, and Copy / CSV / Excel / Print export. Each row shows ordered vs disordered residue fractions (colour bars), a cancer vs disease (OMIM+ClinVar) mutation mix, per–cancer-database variant spectrum (missense, frameshift, indel shares for sources such as TCGA and COSMIC — useful for interpreting oncogene vs tumour-suppressor-style profiles), disease mutation counts, driver census hints, and shortcuts to Summary, PPI, and the REST JSON endpoint.

Open a protein’s Summary (/summary/<accession>/) from the accession link — the main hub for tabbed tables, plots, and the genome-aware sequence view.

Stable deep links use the pattern /search/<search_type>/<term>/ (for example /search/gene_name/RAF1/) and open the protein Summary for that identifier.

The built-in Search page, home box, and navbar quick search (where shown) accept gene symbols, UniProt accessions, Ensembl transcript IDs (stable ENST…), and related text, and resolve to the canonical accession shown in results.

Examples (same pills as on the home page):

• ENST00000393067.8 (transcript)
• RAF1 (gene)
• Q96J92 (UniProt)
• P53_HUMAN (UniProt entry name)

• By gene name — use search_type=gene_name and the HGNC symbol in term (URL-encode spaces if needed).
• By UniProt — use search_type=uniprot and the accession in term.
• By Ensembl transcript — use search_type=ensembl (or other transcript-related types your deployment exposes) with the stable ID. For batch mapping, prefer your own lookup tables or API exports.

After resolution, bookmark or store the gencode / UniProt accession from the results for repeat visits; direct Summary URLs such as /summary/<accession>/ remain valid for opening the report once you know the accession.

Dynamic Search

Browse → Dynamic Search builds arbitrary slices of the proteome: autocomplete on annotation fields, GO terms, disorder- and motif-related columns, and more. Use it when precompiled views are too rigid or when you want to combine several criteria.

Precompiled tables

Precompiled tables host the classic DisCanVis table browser (sortable, filterable columns, including disorder, motifs, domains, and mutation summaries depending on the table). Chromosome- and GO-oriented tables are included here.

Disease tables

• OMIM diseases · ClinVar diseases

Cancer & networks

• Precompiled (incl. Cancer Gene Census drivers) · Significantly mutated regions
• PPI network · Mutation / sample

Disorder- and motif-related dimensions (experimental disorder, ELM, PEM core motifs, ScanSite, MFIB, DIBS, PhasePro, Pfam, …) are columns or dataset presets in Dynamic Search and Precompiled tables — see the home section Explore disorder-specific datasets for a compact map.

Many tables support rich column filters (numeric operators such as >100, negation with ! where implemented). Older pages may use TableSorter widgets; newer views (including Search results) often use DataTables — check the on-page filter row and footer controls.

Summary (/summary/<accession>/) is the primary hub after Search: hero card, coverage badges, and four main pills (Visual Overview, Clinical Views, Statistics, Tables). See Summary page below for a detailed walk-through.

Visual (/visual/…) is the dedicated full-page genome-window viewer (slider, stacked tracks, structure tools). It complements Summary when you want maximum horizontal context in one scrolling canvas.

Both use the same underlying annotation; Summary keeps tables, pathogenicity cards, and exports in one tabbed layout, while Visual emphasises positional scanning along the sequence.

Batch Analysis accepts lists of proteins or genomic regions (see the on-page form for accepted formats and options). The tool returns aggregated structural and functional summaries so you can compare many candidates without opening each protein manually.

Use it after an initial triage in Browse or Search when you need a compact export-style overview of a gene set.

Primarily a research tool for distributions and comparisons across many proteins. For single-variant or single-gene clinical review, start from Search or Mutation / sample (see Use cases).

The Statistics page aggregates precomputed JSON for selectable protein sets: full-proteome and cancer-driver presets, annotation-filtered subsets, or custom sets built from a PPI neighbourhood (seed protein + interaction databases) or a GO term (same autocomplete as Dynamic Browse).

Sections include per-protein overview tables, global disorder distributions, somatic mutation mix by source and variant class (ordered vs disordered sites), mutation–annotation overlap, ClinVar breakdowns, pathogenicity score distributions, and structure-related scores on disordered residues. Colours match Browse Dynamic and Summary palettes.

Human-preset split exports used in publications are linked from Downloads (Proteome statistics category). If charts are empty or show a warning, the underlying preset data may not be published on this server yet.

Search results include a shortcut to open the same protein as REST JSON.

After Search or a browse table, the Summary view is the tabbed per-protein workspace. It loads progressively (loader with per-source chips), then settles into a Protein summary hero and pill navigation that matches the live UI.

Hero — “Protein summary” card

The top card concentrates identity and shortcuts. Typical elements:

Coverage overview (collapsible) expands into badge rows that mirror what finished loading: annotation coverage, cancer-driver flags, somatic cancer types inferred from mutation tables, and disease / cancer mutation sources. UniProt info (collapsible) fetches curated text live from UniProt REST — useful for function summaries without leaving Summary.

Main tabs (pill bar)

The four pills match the in-page Summary navigation:

For a full-width genome slider along the sequence, open Visual (/visual/<accession>/) from the Summary hero; the Visual Overview tab stays inside the tabbed Summary for quick inspection.