Welcome to DisCanVis

A portal for interpreting pathogenic and somatic variants in a disorder-aware way: ordered versus disordered sites, disease context from ClinVar and OMIM, cancer cohort mutations, pathogenicity scores, and overlapping functional annotations.

Three ways in: Search a gene symbol, UniProt accession or Ensembl transcript for one protein’s Summary, which opens on an Overview answering whether its variants fall on ordered or disordered regions; Analysis to ask the same question of a whole set of proteins, regions or studies; or Variant interpretation for a single variant. Bulk files: Downloads. REST & scripting: API.

Help · Cite & updates

Variants & disease

Variant Interpretation for one variant, Analysis for a whole set, or Search to reach one protein’s Summary.

PPI & neighbourhood

PPI network for a seed protein: interaction partners with shared disease and cancer context (IntAct, BioGRID, HIPPIE).

Cancer & disease datasets

Cancer drivers and cohort views: Regions, Significantly mutated regions. Germline disease tables: OMIM, ClinVar.

Disorder annotations

Tracks and columns in Summary, Visual, and Browse:

MFIB DIBS PhasePro ELM PEM ScanSite MobiDB

Explore in Browse & search → Regions.

Explore proteins

Results open in a filterable table with disorder and mutation context. Each protein’s Summary starts on an Overview: whether its variants concentrate in the ordered or the disordered regions, what is annotated where they land, and where in the cell and the body they have been seen.

Quick examples
ENST00000393067.8 RAF1 Q96J92 P53_HUMAN APP-201

Database scale

Live database totals (canonical proteome). Somatic = merged cohort mutations; ClinVar = variant rows; OMIM = same roll-up as OMIM disease browse.

Main isoforms
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Proteome residues
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Summary / Visual track families
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Mutations, pathogenicity, disorder, disorder-binding, Pfam domains, functions, disordered binding, phase separation, DisProt, SLiMs, PTMs, conservation
Somatic variant rows
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Merged cohort tables (missense, frameshift, indel)
ClinVar variant rows
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Clinical significance and disease annotations at protein positions
Pathogenicity predictors
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Shown here, of 41 dbNSFP rankscores loaded — the rest are held back by their licence
MAVE assays
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Measured variant effects from MaveDB, mapped onto these transcripts
Curated disordered regions
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DisProt, plus 2175 phase-separating regions from LLPSDB
Significantly mutated regions
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Spans a density test flagged in the cancer cohorts
OMIM disease browse rows
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Matches OMIM browse table

Explore disorder-specific datasets

Motif, binding and phase-separation layers, each with the variants that fall on them.

Disorder-associated functional sites

MFIB DIBS PhasePro ELM PEM core motifs

Cancer-focused entry points

Start exploring

Search proteins Gene, UniProt accession or GO term → the per-protein Summary.
Browse regions Motifs, domains, disorder and phase separation across the proteome.
Disease tables ClinVar and OMIM germline diseases, grouped by organ system, with the variants behind each.
Significantly mutated regions Cohort ROIs mapped onto the proteome.
PPI network Interaction neighbourhood with shared disease & cancer context.
Variant Interpretation Browse by sample, gene, or position; disorder-aware interpretation.
Analysis Ask one question of a whole set: pick proteins, annotations and variant sources, paste your own regions or scan for a motif, then read the answer as figures or rows.
Portal
Version
DisCanVis 2.0

You are on DisCanVis 2.0 (redesigned portal and UI). To use the previous release, visit v1.discanvis.elte.hu.

Version 1 remains available for legacy workflows and bookmarks.
Focus
Human proteome · disorder-aware interpretation of pathogenic and somatic variants
How to cite

DisCanVis — Deutsch, Pajkos, Erdős, Dosztányi, Protein Science (2022). doi:10.1002/pro.4522

Pathogenic variations in IDPs — Deutsch, Erdős, Dosztányi, iScience (2026). doi:10.1016/j.isci.2026.115215

Community
ELIXIR IDP Community ELIXIR

DisCanVis is developed in the Dosztányi Lab and is part of the ELIXIR intrinsically disordered proteins community, aligned with the broader ELIXIR infrastructure. Training-style documentation lives under Help.

Integrated sources

Disorder & structure

IUPred3 Anchor DisProt MobiDB AlphaFold DB AIUPred binding

Domains, motifs & functional sites

Pfam / InterPro ELM PEM ScanSite MFIB DIBS PhasePro LLPSDB

Variants & cohorts

TCGA COSMIC cBioPortal ClinVar OMIM MaveDB Disease Ontology

Identifiers, interactions & pathogenicity

UniProt GENCODE Gene Ontology IntAct BioGRID HIPPIE dbNSFP AlphaMissense PDB

Figures & ontologies

SwissBioPics EBI Expression Atlas Uberon