Welcome to DisCanVis

A portal for interpreting pathogenic and somatic variants in a disorder-aware way: ordered versus disordered sites, disease context from ClinVar and OMIM, cancer cohort mutations, pathogenicity scores, and overlapping functional annotations.

Use the search below with a gene symbol, UniProt accession, or Ensembl transcript identifier, then open each protein’s Summary from the results table. Bulk files: Downloads. REST & scripting: API.

Learn how to use DisCanVis · Cite & updates

Variants & disease

Mutation / sample, Batch analysis, or Search to reach the per-protein Summary.

PPI & neighbourhood

PPI network for a seed protein: interaction partners with shared disease and cancer context (IntAct, BioGRID, HIPPIE).

Cancer & disease datasets

Cancer drivers and cohort views: Precompiled tables, Dynamic Search, Significantly mutated regions. Germline disease tables: OMIM, ClinVar.

Disorder annotations

Tracks and columns in Summary, Visual, and Browse:

MFIB DIBS PhasePro ELM PEM ScanSite MobiDB

Explore via Dynamic Search and Precompiled tables.

Results open in a filterable table with disorder and mutation context.

Examples
ENST00000393067.8 (transcript) RAF1 (gene) Q96J92 (UniProt entry) P53_HUMAN (UniProt entry name) APP-201 (Gencode)

Database scale

Live database totals (canonical proteome). Somatic = merged cohort mutations; ClinVar = variant rows; OMIM = same roll-up as OMIM disease browse.

Main isoforms
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Proteome residues
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Summary / Visual track families
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Disorder, Pfam, ELM, PEM core motifs, ScanSite, MFIB, DIBS, PhasePro, MobiDB experimental disorder, AIUPred binding, …
Somatic variant rows
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Merged cohort tables (missense, frameshift, indel)
ClinVar variant rows
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Clinical significance and disease annotations at protein positions
OMIM disease browse rows
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Matches OMIM browse table

Explore disorder-specific datasets

Motif / binding / phase-separation layers: Dynamic Search columns or Precompiled slices.

Disorder-associated functional sites

MFIB DIBS PhasePro ELM PEM core motifs

Germline disease variant tables

Cancer-focused entry points

Start exploring

Dynamic search Filter the proteome with GO, disorder fields, and more.
Precompiled tables Sortable browser for curated annotation slices.
Cancer drivers (Census) Driver slices here; also Dynamic Search & mutated regions.
Significantly mutated regions Cohort ROIs mapped onto the proteome.
PPI network Interaction neighbourhood with shared disease & cancer context.
Mutation / sample Paste or upload positions; disorder-aware interpretation.
OMIM diseases Germline disease mutations in disordered context.
ClinVar diseases Clinically reported variants across proteins.
Batch analysis Many proteins or regions in one submission.
Portal
Version
DisCanVis 2.0

You are on DisCanVis 2.0 (redesigned portal and UI). To use the previous release, visit v1.discanvis.elte.hu.

Version 1 remains available for legacy workflows and bookmarks.
Focus
Human proteome · disorder-aware interpretation of pathogenic and somatic variants
How to cite

DisCanVis — Deutsch, Pajkos, Erdős, Dosztányi, Protein Science (2022). doi:10.1002/pro.4522

Pathogenic variations in IDPs — Deutsch, Erdős, Dosztányi, iScience (2026). doi:10.1016/j.isci.2026.115215

Community
ELIXIR IDP Community ELIXIR

DisCanVis is developed in the Dosztányi Lab and is part of the ELIXIR intrinsically disordered proteins community, aligned with the broader ELIXIR infrastructure. Training-style documentation lives under Help.

Integrated sources

Disorder & structure

IUPred3 Anchor DisProt MobiDB AlphaFold DB AIUPred binding

Domains, motifs & functional sites

Pfam / InterPro ELM PEM ScanSite MFIB DIBS PhasePro

Variants & cohorts

TCGA COSMIC cBioPortal ClinVar OMIM

Identifiers, interactions & pathogenicity

UniProt GENCODE Gene Ontology IntAct BioGRID HIPPIE dbNSFP AlphaMissense