Summary

Protein summary Identifiers, quick links, optional coverage detail

hub PPI network

UniProt entry Gene name Gencode Length Chromosome Transcript

Annotation coverage

Cancer driver

Somatic cancer types (from mutation tables)

Disease & cancer mutation sources

UniProt (live)

rest.uniprot.org — not stored locally

Visual settings View mode, focus annotation, track filters

Batch search (import)

Read-only · from Batch analysis

These regions come from regional batch hits sent via Open Summary — Custom view. They are stored separately from editable Custom regions below and do not appear until Custom view is active.

Start	End	Label

Custom regions Plus feature Add / search regions and redraw the plot

Tip: Use Regex on sequence or PSSM scan to quickly add functional regions.

Add ranges manually, scan with a regex, or paste PSSM as JSON (matrix/rows) or TSV (same as Batch Analysis). Batch regional hits use the separate Batch search (import) track above, not this table.

Regex on sequence

PSSM (JSON or TSV)

Min score (optional)

Start	End	Label

Sequence Residue coloring from focus annotation

Tracks Annotations aligned with the label column

Track column: G genome D disorder O ordered M protein level C curated P in silico + title pill · ? details

Track settings

Applies to Summary, Structure, Pathogenicity, Orthologs, and Custom view. Sequence stays on; unchecked tracks are omitted from the plot.

PDB alignments

Load experimental coordinates into the Mol* panel. Chain letter from fused PDB id (e.g. 1A37Q). Same Focus annotation colors as the sequence row (only residues covered by the selected PDB segments, on the listed author chains). Structure track colors still follow PDB’s ordered/disordered labels; the filter below uses combined disorder (≥60% disordered residues in the UniProt span ⇒ “disordered”).

PDB segment filter

AlphaFold

Search PDB table

PDB	Chain(s)	UniProt span	Segments	RCSB

Feature table

Click plot regions to filter

Compare ClinVar benign vs pathogenic score distributions across ordered and disordered sites, review method-specific calibration cutoffs, and inspect per-protein variant context in one workflow.

Variants on this protein

Same sources as Mutation browse. Use Open in VI on a row or enter a custom variant below.

Type	Disease / phenotype	DB	Clinical sig.	Mut	Pos	Site	Analyse

Custom variant (open in Variant Interpretation)

Quick pick from ClinVar or type a variant (e.g. S45F, K1256del), then open full analysis in a new tab.

Position (1-based)

Mutation

Quick pick (ClinVar on this protein)

Quick-pick badges appear here.

Sequence Overview

Disorder Ratio

Disorder Annotation Coverage

Structure and Context

PDB structure overview

Disorder Evolutionary Conservation

Disorder Binding Potential

Pathogenicity Score Distributions (Ordered vs Disordered)

Structural distribution of Mutations

ClinVar disease matrix (site context × significance)

Cancer type matrix (missense only; site context × mutation source)

Cancer type matrix (missense vs frameshift/nonsense by source)

Annotation × mutation source matrix (structure-aware)

Predicted disorder annotations

Predicted disorder annotation coverage

Annotation × mutation source matrix (disordered predicted regions only)

DisCanVis — loading summary

Pathogenicity predictors

Conservation scores

ClinVar accuracy (VEP / pathogenicity predictors)