About DisCanVis

How to cite, what changed recently, and who supports the portal. For workflows and navigation, see Help.

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How to cite

Use the references below for the portal and for related methods papers. Format: full title, authors, journal, date, DOI.

DisCanVis: Integrating structural and functional annotations for the better understanding of the effect of cancer mutations located within disordered proteins

Norbert Deutsch, Mátyás Pajkos, Gábor Erdős, Zsuzsanna Dosztányi

Department of Biochemistry, Institute of Biology, ELTE Eötvös Loránd University, Budapest, Hungary · zsuzsanna.dosztanyi@ttk.elte.hu

Protein Science, 30 November 2022.
DOI: 10.1002/pro.4522

Pathogenic variations illuminate functional constraints in intrinsically disordered proteins

N. Deutsch, G. Erdős, Zsuzsanna Dosztányi

iScience 29 (4), 115215 (2026).
DOI: 10.1016/j.isci.2026.115215

AIUPred–Binding: Energy Embedding to Identify Disordered Binding Regions

G. Erdős, N. Deutsch, Zsuzsanna Dosztányi

Journal of Molecular Biology, 1 August 2025.
DOI: 10.1016/j.jmb.2025.169071

Release notes & recent changes

Portal v2.0

Concise, user-facing changelog. Older data releases (e.g. COSMIC / TCGA / cBioPortal merges) are documented in prior internal notes.

April 2026

Full UI rebrand — DisCanVis 2.0

  • End-to-end visual refresh: Bootstrap-based design system, brand colours, dark-mode–aware Summary (Plotly, cards, sequence toolbar), loaders, and compact navigation.
  • Home page: DisCanVis 2.0 positioning, link to legacy v1.discanvis.elte.hu, search without the old narrow-search gate, refreshed examples (transcript ID, long gene name), live main-isoform database counters, disorder-dataset explorer (MFIB, DIBS, PhasePro, ELM, PEM, …), and a grouped Databases & methods strip (colour keys aligned with Summary / Browse).
  • Footer & About: shorter footer, unified citation formatting, release timeline with calendar months (this page).
  • Continued polish on browse flows, Batch Analysis entry points, and Statistics where applicable.
February 2026

Structure viewer & Summary tracks

  • PDBe Mol* integration and viewer assets revised (plugin bundle under static/plugins/js/pdbe-molstar-old / related CSS), with cleaner loading and layout next to the main Summary plot.
  • Refinement of sequence tracks, mutation layers, and disorder / annotation overlays aligned with the updated viewer stack.
December 2025 – January 2026

Search results & protein triage

  • Unified search results (home, navbar, /search): DataTables table, filters, pagination, Copy / CSV / Excel / Print.
  • Rows show ordered vs disordered composition, cancer vs disease (OMIM + ClinVar) mix, and per-database variant spectrum (missense, frameshift, indel) for TCGA, COSMIC, cBioPortal, etc.
  • Shortcuts to Summary, PPI, and REST JSON.
November 2025

Pathogenicity predictors on Summary

  • Integrated dbNSFP-style ensemble pathogenicity tracks and AlphaMissense alongside existing mutation and disorder layers in the Summary visualisation.
  • Dropdowns and colouring options updated so predictors stay in sync with the sequence view and feature table.
2023 · Data & browse (v1.2 era)

Earlier milestone

  • Expanded somatic mutation coverage (COSMIC, TCGA / legacy TCGA, cBioPortal as deployed).
  • PPI from IntAct, BioGRID, HIPPIE.
  • Extended browse tables (e.g. OMIM diseases, phase separation annotations).
Funding & partners

DisCanVis is supported by Eötvös Loránd University, with additional support from the following partners.

IDP2Biomed
IDP2Biomed

Twinning of research institutions (EU programme).

ELIXIR IDP ELIXIR

DisCanVis is part of the ELIXIR intrinsically disordered proteins community and aligns with the broader ELIXIR infrastructure.