Loading PPI neighbourhood…
Partners, summaries and graph
SIAH1
VHL example

Load a protein to see what kind of neighbourhood it has.

    Open protein summary
    Direct partners
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    in current lens
    Complex leads
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    shared local PDB entries
    Disease leads
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    matched disease mechanism
    IDR mutation leads
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    missense burden in IDR

    Structural shortlist — direct partners in a solved PDB entry

    A shared entry is a complex-context lead, not proof of a direct atomic interface. Open one to see the coloured chains beside both mutation profiles.

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    Complex overview

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    ordered-like (low % dis.)
    disordered-like (high % dis.)
    cancer driver (border)
    shared PDB entry (edge)
    high context score (edge)
    Graph scope
    Nodes shown: —
    Driver nodes: —
    Hub-edge context
    Top N

    What they break in — shared disease and tumour context

    Curated diseases both are annotated to, and the tumour types where the pair's somatic load sits together.

    Same job — partners by shared biological process

    Each shared GO process weighted by how rare it is in this neighbourhood, so a term everyone carries counts for almost nothing.

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    Mechanistic partner shortlist

    One row is one direct partner. Filters above decide the shared network state; this table explains each candidate through disease group, mutation/IDR context, domains, ligands and local structural mapping.