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Total number of protein in "GO:0010243" GO term:  555

Identifier UniProt Gene UniProt Accession UniProt Name Chromosome GO term Database Cancer Driver Number of missense mutations Missense mutation per residues Number of disordered residues Number of mutations in disordered regions Disordered missense mutations per residues Number of OMIM mutation
AANAT_ENST00000392492 AANAT Q16613 Serotonin N-acetyltransferase chr17 GO:0010243 Not Cancer Driver No 22 0.106 28 4 0.143 0
ABCA1 ABCA1 O95477 Phospholipid-transporting ATPase ABCA1 chr9 GO:0010243 Not Cancer Driver No 284 0.126 245 40 0.163 31
ABCC1 ABCC1 P33527 Multidrug resistance-associated protein 1 chr16 GO:0010243 Not Cancer Driver No 199 0.13 123 22 0.179 1
ABCC9_ENST00000261201 ABCC9 O60706 ATP-binding cassette sub-family C member 9 chr12 GO:0010243 Not Cancer Driver No 368 0.238 132 30 0.227 15
ABL1_ENST00000318560 ABL1 P00519 Tyrosine-protein kinase ABL1 chr9 GO:0010243 Census, Compendium Yes 139 0.123 604 73 0.121 2
ACTB_ENST00000646664 ACTB P60709 Actin, cytoplasmic 1 chr7 GO:0010243 Not Cancer Driver No 112 0.299 43 5 0.116 5
ACTR2_ENST00000260641 ACTR2 P61160 Actin-related protein 2 chr2 GO:0010243 Not Cancer Driver No 51 0.129 6 2 0.333 0
ADAMTS13 ADAMTS13 Q76LX8 A disintegrin and metalloproteinase with thrombospondin motifs 13 chr9 GO:0010243 Not Cancer Driver No 172 0.121 285 35 0.123 43
ADCY6 ADCY6 O43306 Adenylate cyclase type 6 chr12 GO:0010243 Not Cancer Driver No 144 0.123 147 17 0.116 1
ADCY8 ADCY8 P40145 Adenylate cyclase type 8 chr8 GO:0010243 Not Cancer Driver No 419 0.335 215 38 0.177 0
ADIPOQ ADIPOQ Q15848 Adiponectin chr3 GO:0010243 Not Cancer Driver No 39 0.16 92 21 0.228 1
ADORA2A ADORA2A P29274 Adenosine receptor A2a chr22 GO:0010243 Not Cancer Driver No 61 0.148 93 11 0.118 0
ADRB2 ADRB2 P07550 Beta-2 adrenergic receptor chr5 GO:0010243 Not Cancer Driver No 52 0.126 35 4 0.114 0
ADSS ADSS2 P30520 Adenylosuccinate synthetase isozyme 2 chr1 GO:0010243 Not Cancer Driver No 49 0.107 48 4 0.083 0
ADTRP_ENST00000414691 ADTRP Q96IZ2 Androgen-dependent TFPI-regulating protein chr6 GO:0010243 Not Cancer Driver No 41 0.178 2 0 0.0 0
AGER_ENST00000375076 AGER Q15109 Advanced glycosylation end product-specific receptor chr6 GO:0010243 Not Cancer Driver No 31 0.077 297 21 0.071 0
AGT AGT P01019 Angiotensinogen chr1 GO:0010243 Not Cancer Driver No 85 0.179 33 10 0.303 1
AHR AHR P35869 Aryl hydrocarbon receptor chr7 GO:0010243 Not Cancer Driver No 129 0.152 351 75 0.214 0
AIF1 AIF1 P55008 Allograft inflammatory factor 1 chr6 GO:0010243 Not Cancer Driver No 14 0.095 61 6 0.098 0
AIFM1 AIFM1 O95831 Apoptosis-inducing factor 1, mitochondrial chrX GO:0010243 Not Cancer Driver No 88 0.144 166 22 0.133 11
AKAP6 AKAP6 Q13023 A-kinase anchor protein 6 chr14 GO:0010243 Not Cancer Driver No 383 0.165 1456 240 0.165 0
AKAP9 AKAP9 Q99996 A-kinase anchor protein 9 chr7 GO:0010243 Census Yes 474 0.121 2281 268 0.117 1
AKT1_ENST00000349310 AKT1 P31749 RAC-alpha serine/threonine-protein kinase chr14 GO:0010243 Census, Compendium Yes 108 0.225 158 24 0.152 4
ALAD ALAD P13716 Delta-aminolevulinic acid dehydratase chr9 GO:0010243 Not Cancer Driver No 52 0.158 13 3 0.231 5
AMIGO1_ENST00000369862 AMIGO1 Q86WK6 Amphoterin-induced protein 1 chr1 GO:0010243 Not Cancer Driver No 46 0.093 85 7 0.082 0
AOC1_ENST00000467291 AOC1 P19801 Amiloride-sensitive amine oxidase [copper-containing] chr7 GO:0010243 Not Cancer Driver No 161 0.214 98 26 0.265 0
APEX1_ENST00000555414 APEX1 P27695 DNA-(apurinic or apyrimidinic site) endonuclease chr14 GO:0010243 Not Cancer Driver No 34 0.107 103 14 0.136 0
APLP1 APLP1 P51693 Amyloid beta precursor like protein 1 chr19 GO:0010243 Not Cancer Driver No 146 0.225 455 98 0.215 0
APP APP P05067 Amyloid-beta precursor protein chr21 GO:0010243 Not Cancer Driver No 128 0.166 418 71 0.17 17
AQP1 AQP1 P29972 Aquaporin-1 chr7 GO:0010243 Not Cancer Driver No 39 0.145 4 1 0.25 0
AQP8 AQP8 O94778 Aquaporin-8 chr16 GO:0010243 Not Cancer Driver No 49 0.188 0 0 0.0 0
AQP9 AQP9 O43315 Aquaporin-9 chr15 GO:0010243 Not Cancer Driver No 75 0.254 12 0 0.0 0
AREG AREG P15514 Amphiregulin chr4 GO:0010243 Not Cancer Driver No 28 0.111 149 20 0.134 0
ARG1_ENST00000368087 ARG1 P05089 Arginase-1 chr6 GO:0010243 Not Cancer Driver No 41 0.127 83 12 0.145 9
ARHGEF2 ARHGEF2 Q92974 Rho guanine nucleotide exchange factor 2 chr1 GO:0010243 Not Cancer Driver No 146 0.148 450 70 0.156 0
ASCL1 ASCL1 P50553 Achaete-scute homolog 1 chr12 GO:0010243 Not Cancer Driver No 33 0.14 182 24 0.132 0
ASIC1_ENST00000447966 ASIC1 P78348 Acid-sensing ion channel 1 chr12 GO:0010243 Not Cancer Driver No 69 0.131 17 2 0.118 0
ASS1_ENST00000352480 ASS1 P00966 Argininosuccinate synthase chr9 GO:0010243 Not Cancer Driver No 65 0.158 63 8 0.127 86
ATF2 ATF2 P15336 Cyclic AMP-dependent transcription factor ATF-2 chr2 GO:0010243 Not Cancer Driver No 65 0.129 451 58 0.129 0
ATF4_ENST00000404241 ATF4 P18848 Cyclic AMP-dependent transcription factor ATF-4 chr22 GO:0010243 Not Cancer Driver No 53 0.151 259 38 0.147 0
ATP1A3_ENST00000302102 ATP1A3 P13637 Sodium/potassium-transporting ATPase subunit alpha-3 chr19 GO:0010243 Not Cancer Driver No 200 0.197 115 29 0.252 31
ATP4B ATP4B P51164 Potassium-transporting ATPase subunit beta chr13 GO:0010243 Not Cancer Driver No 35 0.12 2 0 0.0 0
ATP7A ATP7A Q04656 Copper-transporting ATPase 1 chrX GO:0010243 Not Cancer Driver No 228 0.152 171 46 0.269 52
AUP1 AUP1 Q9Y679 Lipid droplet-regulating VLDL assembly factor AUP1 chr2 GO:0010243 Not Cancer Driver No 41 0.1 122 13 0.107 0
BACE1 BACE1 P56817 Beta-secretase 1 chr11 GO:0010243 Not Cancer Driver No 55 0.11 53 5 0.094 0
BAD_ENST00000309032 BAD Q92934 Bcl2-associated agonist of cell death chr11 GO:0010243 Not Cancer Driver No 14 0.083 163 14 0.086 0
BAG6 BAG6 P46379 Large proline-rich protein BAG6 chr6 GO:0010243 Not Cancer Driver No 98 0.087 861 79 0.092 0
BAIAP2 BAIAP2 Q9UQB8 Brain-specific angiogenesis inhibitor 1-associated protein 2 chr17 GO:0010243 Not Cancer Driver No 85 0.154 330 52 0.158 0
BCHE BCHE P06276 Cholinesterase chr3 GO:0010243 Not Cancer Driver No 185 0.307 14 4 0.286 38
BCKDHB BCKDHB P21953 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial chr6 GO:0010243 Not Cancer Driver No 47 0.12 23 3 0.13 5
BCL11A BCL11A Q9H165 B-cell lymphoma/leukemia 11A chr2 GO:0010243 Census, Compendium Yes 210 0.251 677 171 0.253 3
BCL2L1 BCL2L1 Q07817 Bcl-2-like protein 1 chr20 GO:0010243 Not Cancer Driver No 29 0.124 55 3 0.055 0
BCL2L11 BCL2L11 O43521 Bcl-2-like protein 11 chr2 GO:0010243 Not Cancer Driver No 42 0.212 130 17 0.131 0
BCL2L2 BCL2L2 Q92843 Bcl-2-like protein 2 chr14 GO:0010243 Not Cancer Driver No 22 0.114 34 6 0.176 0
BIRC2 BIRC2 Q13490 Baculoviral IAP repeat-containing protein 2 chr11 GO:0010243 Not Cancer Driver No 69 0.112 83 9 0.108 0
BLM BLM P54132 Bloom syndrome protein chr15 GO:0010243 Census Yes 153 0.108 667 70 0.105 8
BRCA1_ENST00000357654 BRCA1 P38398 Breast cancer type 1 susceptibility protein chr17 GO:0010243 Census, Compendium Yes 224 0.12 1458 174 0.119 35
BRIP1 BRIP1 Q9BX63 Fanconi anemia group J protein chr17 GO:0010243 Census Yes 174 0.139 397 59 0.149 6
BSG BSG P35613 Basigin chr19 GO:0010243 Not Cancer Driver No 43 0.112 123 17 0.138 0
C5AR1 C5AR1 P21730 C5a anaphylatoxin chemotactic receptor 1 chr19 GO:0010243 Not Cancer Driver No 71 0.203 0 0 0.0 0
CACNA1A_ENST00000360228 CACNA1A O00555 Voltage-dependent P/Q-type calcium channel subunit alpha-1A chr19 GO:0010243 Not Cancer Driver No 436 0.174 1144 132 0.115 46
CACNA1B CACNA1B Q00975 Voltage-dependent N-type calcium channel subunit alpha-1B chr9 GO:0010243 Not Cancer Driver No 416 0.178 917 115 0.125 0
CACNA1S CACNA1S Q13698 Voltage-dependent L-type calcium channel subunit alpha-1S chr1 GO:0010243 Not Cancer Driver No 389 0.208 382 76 0.199 6
CACNA2D1_ENST00000356253 CACNA2D1 P54289 Voltage-dependent calcium channel subunit alpha-2/delta-1 chr7 GO:0010243 Not Cancer Driver No 277 0.251 99 25 0.253 0
CACNB1 CACNB1 Q02641 Voltage-dependent L-type calcium channel subunit beta-1 chr17 GO:0010243 Not Cancer Driver No 75 0.125 396 47 0.119 0
CACNG4 CACNG4 Q9UBN1 Voltage-dependent calcium channel gamma-4 subunit chr17 GO:0010243 Not Cancer Driver No 51 0.156 71 17 0.239 0
CALCR_ENST00000394441 CALCR P30988 Calcitonin receptor chr7 GO:0010243 Not Cancer Driver No 162 0.342 29 9 0.31 0
CALM3_ENST00000596362 CALM3 P0DP25 Calmodulin-3 chr19 GO:0010243 Not Cancer Driver No 17 0.114 115 10 0.087 3
CAMP CAMP P49913 Cathelicidin antimicrobial peptide chr3 GO:0010243 Not Cancer Driver No 25 0.147 48 4 0.083 0
CAPN2 CAPN2 P17655 Calpain-2 catalytic subunit chr1 GO:0010243 Not Cancer Driver No 81 0.116 46 11 0.239 0
CARD9 CARD9 Q9H257 Caspase recruitment domain-containing protein 9 chr9 GO:0010243 Not Cancer Driver No 72 0.134 225 35 0.156 11
CARM1 CARM1 Q86X55 Histone-arginine methyltransferase CARM1 chr19 GO:0010243 Not Cancer Driver No 62 0.102 102 10 0.098 0
CASP3 CASP3 P42574 Caspase-3 chr4 GO:0010243 Census Yes 32 0.116 62 5 0.081 0
CASP4 CASP4 P49662 Caspase-4 chr11 GO:0010243 Not Cancer Driver No 56 0.149 102 14 0.137 0
CASP6 CASP6 P55212 Caspase-6 chr4 GO:0010243 Not Cancer Driver No 28 0.096 24 4 0.167 0
CASP7_ENST00000345633 CASP7 P55210 Caspase-7 chr10 GO:0010243 Not Cancer Driver No 38 0.125 73 10 0.137 0
CASQ2 CASQ2 O14958 Calsequestrin-2 chr1 GO:0010243 Not Cancer Driver No 74 0.185 75 16 0.213 4
CASR_ENST00000638421 CASR P41180 Extracellular calcium-sensing receptor chr3 GO:0010243 Not Cancer Driver No 304 0.282 189 60 0.317 108
CASTOR1 CASTOR1 Q8WTX7 Cytosolic arginine sensor for mTORC1 subunit 1 chr22 GO:0010243 Not Cancer Driver No 27 0.082 39 5 0.128 0
CASTOR3 CASTOR3 Q8NAP1 Putative protein CASTOR 3 chr7 GO:0010243 Not Cancer Driver No 18 0.11 1 0 0.0 0
CCN2 CCN2 P29279 CCN family member 2 chr6 GO:0010243 Not Cancer Driver No 58 0.166 0 0 0.0 0
CCNA2_ENST00000618014 CCNA2 P20248 Cyclin-A2 chr4 GO:0010243 Not Cancer Driver No 45 0.104 186 19 0.102 0
CCND1 CCND1 P24385 G1/S-specific cyclin-D1 chr11 GO:0010243 Census, Compendium Yes 55 0.186 31 25 0.806 0
CCNG1_ENST00000393929 CCNG1 P51959 Cyclin-G1 chr5 GO:0010243 Not Cancer Driver No 25 0.085 0 0 0.0 0
CD36_ENST00000309881 CD36 P16671 Platelet glycoprotein 4 chr7 GO:0010243 Not Cancer Driver No 75 0.159 12 3 0.25 3
CD68 CD68 P34810 Macrosialin chr17 GO:0010243 Not Cancer Driver No 26 0.073 192 13 0.068 0
CD81 CD81 P60033 CD81 antigen chr11 GO:0010243 Not Cancer Driver No 28 0.119 0 0 0.0 0
CD9 CD9 P21926 CD9 antigen chr12 GO:0010243 Not Cancer Driver No 22 0.096 0 0 0.0 0
CDA CDA P32320 Cytidine deaminase chr1 GO:0010243 Not Cancer Driver No 21 0.144 8 0 0.0 0
CDC6 CDC6 Q99741 Cell division control protein 6 homolog chr17 GO:0010243 Not Cancer Driver No 57 0.102 170 15 0.088 1
CDH1 CDH1 P12830 Cadherin-1 chr16 GO:0010243 Census, Compendium Yes 150 0.17 400 82 0.205 5
CDK1 CDK1 P06493 Cyclin-dependent kinase 1 chr10 GO:0010243 Not Cancer Driver No 40 0.135 1 0 0.0 0
CDK5 CDK5 Q00535 Cyclin-dependent kinase 5 chr7 GO:0010243 Not Cancer Driver No 48 0.164 5 1 0.2 0
CDKN1B CDKN1B P46527 Cyclin-dependent kinase inhibitor 1B chr12 GO:0010243 Census, Compendium Yes 19 0.096 198 19 0.096 0
CDO1 CDO1 Q16878 Cysteine dioxygenase type 1 chr5 GO:0010243 Not Cancer Driver No 37 0.185 43 4 0.093 0
CEBPB CEBPB P17676 CCAAT/enhancer-binding protein beta chr20 GO:0010243 Not Cancer Driver No 3 0.009 276 2 0.007 0
CES1_ENST00000361503 CES1 P23141 Liver carboxylesterase 1 chr16 GO:0010243 Not Cancer Driver No 138 0.243 41 2 0.049 0
CFTR CFTR P13569 Cystic fibrosis transmembrane conductance regulator chr7 GO:0010243 Not Cancer Driver No 287 0.194 145 18 0.124 151
CHEK1_ENST00000428830 CHEK1 O14757 Serine/threonine-protein kinase Chk1 chr11 GO:0010243 Not Cancer Driver No 58 0.122 86 16 0.186 0
CHMP5 CHMP5 Q9NZZ3 Charged multivesicular body protein 5 chr9 GO:0010243 Not Cancer Driver No 24 0.11 195 18 0.092 0
CHRNA7_ENST00000306901 CHRNA7 P36544 Neuronal acetylcholine receptor subunit alpha-7 chr15 GO:0010243 Not Cancer Driver No 71 0.141 18 4 0.222 0
CHRNB2 CHRNB2 P17787 Neuronal acetylcholine receptor subunit beta-2 chr1 GO:0010243 Not Cancer Driver No 92 0.183 23 2 0.087 2
CIB2 CIB2 O75838 Calcium and integrin-binding family member 2 chr15 GO:0010243 Not Cancer Driver No 25 0.134 7 0 0.0 5
CITED1_ENST00000246139 CITED1 Q99966 Cbp/p300-interacting transactivator 1 chrX GO:0010243 Not Cancer Driver No 24 0.124 166 21 0.127 0
CNGA3 CNGA3 Q16281 Cyclic nucleotide-gated cation channel alpha-3 chr2 GO:0010243 Not Cancer Driver No 183 0.264 217 67 0.309 53
CNR1_ENST00000549890 CNR1 P21554 Cannabinoid receptor 1 chr6 GO:0010243 Not Cancer Driver No 129 0.273 9 1 0.111 0
CNR2 CNR2 P34972 Cannabinoid receptor 2 chr1 GO:0010243 Not Cancer Driver No 57 0.158 21 4 0.19 0
COL16A1 COL16A1 Q07092 Collagen alpha-1(XVI) chain chr1 GO:0010243 Not Cancer Driver No 192 0.12 1381 163 0.118 0
COL1A1 COL1A1 P02452 Collagen alpha-1(I) chain chr17 GO:0010243 Census, Compendium Yes 247 0.169 1212 214 0.177 148
COL1A2 COL1A2 P08123 Collagen alpha-2(I) chain chr7 GO:0010243 Not Cancer Driver No 372 0.272 1159 329 0.284 83
COL3A1 COL3A1 P02461 Collagen alpha-1(III) chain chr2 GO:0010243 Census Yes 402 0.274 1182 337 0.285 103
COL4A1 COL4A1 P02462 Collagen alpha-1(IV) chain chr13 GO:0010243 Not Cancer Driver No 349 0.209 1457 310 0.213 32
COL4A6_ENST00000372216 COL4A6 Q14031 Collagen alpha-6(IV) chain chrX GO:0010243 Not Cancer Driver No 286 0.169 1451 255 0.176 1
COL5A2 COL5A2 P05997 Collagen alpha-2(V) chain chr2 GO:0010243 Not Cancer Driver No 350 0.233 1276 297 0.233 2
COL6A1 COL6A1 P12109 Collagen alpha-1(VI) chain chr21 GO:0010243 Not Cancer Driver No 145 0.141 434 61 0.141 12
CPEB1_ENST00000611031 CPEB1 Q9BZB8 Cytoplasmic polyadenylation element-binding protein 1 chr15 GO:0010243 Not Cancer Driver No 90 0.159 226 37 0.164 0
CPEB3_ENST00000265997 CPEB3 Q8NE35 Cytoplasmic polyadenylation element-binding protein 3 chr10 GO:0010243 Census, Compendium Yes 66 0.095 414 28 0.068 0
CPEB4 CPEB4 Q17RY0 Cytoplasmic polyadenylation element-binding protein 4 chr5 GO:0010243 Not Cancer Driver No 85 0.117 443 54 0.122 0
CPS1_ENST00000233072 CPS1 P31327 Carbamoyl-phosphate synthase [ammonia], mitochondrial chr2 GO:0010243 Not Cancer Driver No 368 0.245 73 22 0.301 140
CPT1A_ENST00000539743 CPT1A P50416 Carnitine O-palmitoyltransferase 1, liver isoform chr11 GO:0010243 Not Cancer Driver No 144 0.186 62 10 0.161 15
CREB1_ENST00000430624 CREB1 P16220 Cyclic AMP-responsive element-binding protein 1 chr2 GO:0010243 Census Yes 25 0.076 277 23 0.083 0
CRHBP CRHBP P24387 Corticotropin-releasing factor-binding protein chr5 GO:0010243 Not Cancer Driver No 61 0.189 0 0 0.0 0
CRHR1 CRHR1 P34998 Corticotropin-releasing factor receptor 1 chr17 GO:0010243 Not Cancer Driver No 75 0.169 0 0 0.0 0
CRHR2_ENST00000471646 CRHR2 Q13324 Corticotropin-releasing factor receptor 2 chr7 GO:0010243 Not Cancer Driver No 79 0.192 0 0 0.0 0
CRK CRK P46108 Adapter molecule crk chr17 GO:0010243 Not Cancer Driver No 30 0.099 197 23 0.117 0
CRLS1 CRLS1 Q9UJA2 Cardiolipin synthase (CMP-forming) chr20 GO:0010243 Not Cancer Driver No 18 0.06 36 0 0.0 0
CRY1 CRY1 Q16526 Cryptochrome-1 chr12 GO:0010243 Not Cancer Driver No 76 0.13 91 5 0.055 0
CTNNA1 CTNNA1 P35221 Catenin alpha-1 chr5 GO:0010243 Census Yes 126 0.139 268 35 0.131 4
CTNNB1_ENST00000643977 CTNNB1 P35222 Catenin beta-1 chr3 GO:0010243 Census, Compendium Yes 415 0.531 288 301 1.045 14
CXCR4_ENST00000241393 CXCR4 P61073 C-X-C chemokine receptor type 4 chr2 GO:0010243 Census, Compendium Yes 62 0.176 5 1 0.2 0
CYBA CYBA P13498 Cytochrome b-245 light chain chr16 GO:0010243 Not Cancer Driver No 26 0.133 66 2 0.03 12
CYBB CYBB P04839 Cytochrome b-245 heavy chain chrX GO:0010243 Not Cancer Driver No 109 0.191 11 3 0.273 65
CYC1 CYC1 P08574 Cytochrome c1, heme protein, mitochondrial chr8 GO:0010243 Not Cancer Driver No 65 0.2 35 8 0.229 2
CYP1B1 CYP1B1 Q16678 Cytochrome P450 1B1 chr2 GO:0010243 Not Cancer Driver No 61 0.112 31 3 0.097 40
CYP2E1_ENST00000252945 CYP2E1 P05181 Cytochrome P450 2E1 chr10 GO:0010243 Not Cancer Driver No 87 0.176 21 6 0.286 0
CYSLTR2_ENST00000614739 CYSLTR2 Q9NS75 Cysteinyl leukotriene receptor 2 chr13 GO:0010243 Census, Compendium Yes 64 0.185 0 0 0.0 0
DBH DBH P09172 Dopamine beta-hydroxylase chr9 GO:0010243 Not Cancer Driver No 125 0.203 71 17 0.239 3
DDC DDC P20711 Aromatic-L-amino-acid decarboxylase chr7 GO:0010243 Not Cancer Driver No 98 0.204 5 0 0.0 9
DDX11 DDX11 Q96FC9 ATP-dependent DNA helicase DDX11 chr12 GO:0010243 Not Cancer Driver No 154 0.159 280 55 0.196 1
DEFB124 DEFB124 Q8NES8 Beta-defensin 124 chr20 GO:0010243 Not Cancer Driver No 9 0.127 3 0 0.0 0
DERL1 DERL1 Q9BUN8 Derlin-1 chr8 GO:0010243 Not Cancer Driver No 28 0.112 11 1 0.091 0
DGKQ DGKQ P52824 Diacylglycerol kinase theta chr4 GO:0010243 Not Cancer Driver No 56 0.059 264 11 0.042 0
DHFR DHFR P00374 Dihydrofolate reductase chr5 GO:0010243 Not Cancer Driver No 16 0.086 12 2 0.167 2
DHX15 DHX15 O43143 ATP-dependent RNA helicase DHX15 chr4 GO:0010243 Not Cancer Driver No 110 0.138 180 30 0.167 0
DIAPH1 DIAPH1 O60610 Protein diaphanous homolog 1 chr5 GO:0010243 Not Cancer Driver No 118 0.093 692 57 0.082 1
DMTN_ENST00000358242 DMTN Q08495 Dematin chr8 GO:0010243 Not Cancer Driver No 53 0.131 348 46 0.132 0
DNM2_ENST00000355667 DNM2 P50570 Dynamin-2 chr19 GO:0010243 Census Yes 138 0.159 270 43 0.159 22
DNMT1_ENST00000340748 DNMT1 P26358 DNA (cytosine-5)-methyltransferase 1 chr19 GO:0010243 Not Cancer Driver No 203 0.126 702 78 0.111 4
DNMT3A DNMT3A Q9Y6K1 DNA (cytosine-5)-methyltransferase 3A chr2 GO:0010243 Census, Compendium Yes 194 0.213 371 59 0.159 16
DRD1 DRD1 P21728 D(1A) dopamine receptor chr5 GO:0010243 Not Cancer Driver No 73 0.164 30 4 0.133 0
DRD2_ENST00000542968 DRD2 P14416 D(2) dopamine receptor chr11 GO:0010243 Not Cancer Driver No 127 0.287 124 45 0.363 0
DRD3_ENST00000460779 DRD3 P35462 D(3) dopamine receptor chr3 GO:0010243 Not Cancer Driver No 88 0.22 45 17 0.378 0
DRD4 DRD4 P21917 D(4) dopamine receptor chr11 GO:0010243 Not Cancer Driver No 26 0.062 109 0 0.0 0
DRD5 DRD5 P21918 D(1B) dopamine receptor chr4 GO:0010243 Not Cancer Driver No 172 0.361 29 18 0.621 0
DUOX1 DUOX1 Q9NRD9 Dual oxidase 1 chr15 GO:0010243 Not Cancer Driver No 193 0.124 158 17 0.108 0
DUOX2 DUOX2 Q9NRD8 Dual oxidase 2 chr15 GO:0010243 Not Cancer Driver No 245 0.158 182 25 0.137 3
EDEM1 EDEM1 Q92611 ER degradation-enhancing alpha-mannosidase-like protein 1 chr3 GO:0010243 Not Cancer Driver No 54 0.082 141 5 0.035 0
EDEM2 EDEM2 Q9BV94 ER degradation-enhancing alpha-mannosidase-like protein 2 chr20 GO:0010243 Not Cancer Driver No 69 0.119 54 3 0.056 0
EDN1 EDN1 P05305 Endothelin-1 chr6 GO:0010243 Not Cancer Driver No 37 0.175 97 20 0.206 3
EDNRA EDNRA P25101 Endothelin-1 receptor chr4 GO:0010243 Not Cancer Driver No 62 0.145 21 6 0.286 2
EDNRB_ENST00000334286 EDNRB P24530 Endothelin receptor type B chr13 GO:0010243 Not Cancer Driver No 112 0.253 56 19 0.339 6
EEF2K EEF2K O00418 Eukaryotic elongation factor 2 kinase chr16 GO:0010243 Not Cancer Driver No 104 0.143 311 39 0.125 0
EFTUD2 EFTUD2 Q15029 116 kDa U5 small nuclear ribonucleoprotein component chr17 GO:0010243 Compendium Yes 132 0.136 179 30 0.168 3
EGFR EGFR P00533 Epidermal growth factor receptor chr7 GO:0010243 Census, Compendium Yes 444 0.367 223 35 0.157 1
EGR1 EGR1 P18146 Early growth response protein 1 chr5 GO:0010243 Not Cancer Driver No 78 0.144 501 72 0.144 0
EHMT2_ENST00000375537 EHMT2 Q96KQ7 Histone-lysine N-methyltransferase EHMT2 chr6 GO:0010243 Not Cancer Driver No 142 0.117 585 71 0.121 0
ELAVL4_ENST00000371821 ELAVL4 P26378 ELAV-like protein 4 chr1 GO:0010243 Not Cancer Driver No 118 0.306 117 34 0.291 0
EN1 EN1 Q05925 Homeobox protein engrailed-1 chr2 GO:0010243 Not Cancer Driver No 42 0.107 357 30 0.084 0
EPHA4_ENST00000409938 EPHA4 P54764 Ephrin type-A receptor 4 chr2 GO:0010243 Not Cancer Driver No 182 0.185 140 24 0.171 0
EPHB2 EPHB2 P29323 Ephrin type-B receptor 2 chr1 GO:0010243 Not Cancer Driver No 186 0.176 119 17 0.143 7
ERBIN_ENST00000284037 ERBIN Q96RT1 Erbin chr5 GO:0010243 Not Cancer Driver No 167 0.118 967 118 0.122 0
EXT1 EXT1 Q16394 Exostosin-1 chr8 GO:0010243 Census Yes 107 0.143 58 7 0.121 12
EZH2_ENST00000460911 EZH2 Q15910 Histone-lysine N-methyltransferase EZH2 chr7 GO:0010243 Census, Compendium Yes 120 0.161 284 44 0.155 11
EZR EZR P15311 Ezrin chr6 GO:0010243 Census Yes 66 0.113 295 35 0.119 0
F7 F7 P08709 Coagulation factor VII chr13 GO:0010243 Not Cancer Driver No 74 0.159 50 7 0.14 108
FADD FADD Q13158 FAS-associated death domain protein chr11 GO:0010243 Not Cancer Driver No 26 0.125 45 10 0.222 1
FBN1 FBN1 P35555 Fibrillin-1 chr15 GO:0010243 Not Cancer Driver No 466 0.162 110 16 0.145 360
FCER1G FCER1G P30273 High affinity immunoglobulin epsilon receptor subunit gamma chr1 GO:0010243 Not Cancer Driver No 10 0.116 13 2 0.154 0
FCGR2B FCGR2B P31994 Low affinity immunoglobulin gamma Fc region receptor II-b chr1 GO:0010243 Census Yes 51 0.165 99 30 0.303 0
FDX1 FDX1 P10109 Adrenodoxin, mitochondrial chr11 GO:0010243 Not Cancer Driver No 12 0.065 61 2 0.033 0
FGF21 FGF21 Q9NSA1 Fibroblast growth factor 21 chr19 GO:0010243 Not Cancer Driver No 37 0.177 109 24 0.22 0
FLT3 FLT3 P36888 Receptor-type tyrosine-protein kinase FLT3 chr13 GO:0010243 Census, Compendium Yes 200 0.201 64 27 0.422 0
FOLR1_ENST00000393681 FOLR1 P15328 Folate receptor alpha chr11 GO:0010243 Not Cancer Driver No 41 0.16 13 3 0.231 0
FOLR2 FOLR2 P14207 Folate receptor beta chr11 GO:0010243 Not Cancer Driver No 32 0.125 6 0 0.0 0
FOS FOS P01100 Protein c-Fos chr14 GO:0010243 Not Cancer Driver No 45 0.118 245 33 0.135 0
FOSB FOSB P53539 Protein FosB chr19 GO:0010243 Not Cancer Driver No 50 0.148 313 44 0.141 0
FOSL1 FOSL1 P15407 Fos-related antigen 1 chr11 GO:0010243 Not Cancer Driver No 24 0.089 271 24 0.089 0
FOXO3 FOXO3 O43524 Forkhead box protein O3 chr6 GO:0010243 Census, Compendium Yes 70 0.104 595 68 0.114 0
FOXP3 FOXP3 Q9BZS1 Forkhead box protein P3 chrX GO:0010243 Not Cancer Driver No 38 0.088 186 16 0.086 10
FPR2 FPR2 P25090 N-formyl peptide receptor 2 chr19 GO:0010243 Not Cancer Driver No 96 0.274 26 5 0.192 0
FUK FCSK Q8N0W3 L-fucose kinase chr16 GO:0010243 Not Cancer Driver No 102 0.094 26 1 0.038 0
FUNDC1 FUNDC1 Q8IVP5 FUN14 domain-containing protein 1 chrX GO:0010243 Not Cancer Driver No 16 0.103 24 2 0.083 0
FYN FYN P06241 Tyrosine-protein kinase Fyn chr6 GO:0010243 Not Cancer Driver No 92 0.171 70 13 0.186 0
GABPA_ENST00000400075 GABPA Q06546 GA-binding protein alpha chain chr21 GO:0010243 Not Cancer Driver No 58 0.128 103 8 0.078 0
GABRB1 GABRB1 P18505 Gamma-aminobutyric acid receptor subunit beta-1 chr4 GO:0010243 Not Cancer Driver No 133 0.281 43 14 0.326 2
GABRB2_ENST00000393959 GABRB2 P47870 Gamma-aminobutyric acid receptor subunit beta-2 chr5 GO:0010243 Not Cancer Driver No 165 0.322 27 10 0.37 1
GABRB3 GABRB3 P28472 Gamma-aminobutyric acid receptor subunit beta-3 chr15 GO:0010243 Not Cancer Driver No 178 0.376 56 22 0.393 9
GABRG2_ENST00000639213 GABRG2 P18507 Gamma-aminobutyric acid receptor subunit gamma-2 chr5 GO:0010243 Not Cancer Driver No 188 0.403 19 13 0.684 11
GATA1 GATA1 P15976 Erythroid transcription factor chrX GO:0010243 Census, Compendium Yes 68 0.165 242 41 0.169 5
GATA6 GATA6 Q92908 Transcription factor GATA-6 chr18 GO:0010243 Not Cancer Driver No 57 0.096 476 51 0.107 10
GCGR GCGR P47871 Glucagon receptor chr17 GO:0010243 Not Cancer Driver No 16 0.034 56 2 0.036 4
GCLC GCLC P48506 Glutamate--cysteine ligase catalytic subunit chr6 GO:0010243 Not Cancer Driver No 73 0.115 167 18 0.108 3
GCLM GCLM P48507 Glutamate--cysteine ligase regulatory subunit chr1 GO:0010243 Not Cancer Driver No 32 0.117 31 3 0.097 0
GFER GFER P55789 FAD-linked sulfhydryl oxidase ALR chr16 GO:0010243 Not Cancer Driver No 10 0.049 97 4 0.041 1
GHR_ENST00000612382 GHR P10912 Growth hormone receptor chr5 GO:0010243 Not Cancer Driver No 173 0.271 229 66 0.288 19
GHSR GHSR Q92847 Growth hormone secretagogue receptor type 1 chr3 GO:0010243 Not Cancer Driver No 85 0.232 4 0 0.0 2
GIP GIP P09681 Gastric inhibitory polypeptide chr17 GO:0010243 Not Cancer Driver No 35 0.229 68 16 0.235 0
GJA1 GJA1 P17302 Gap junction alpha-1 protein chr6 GO:0010243 Not Cancer Driver No 86 0.225 110 26 0.236 50
GJB2_ENST00000382848 GJB2 P29033 Gap junction beta-2 protein chr13 GO:0010243 Not Cancer Driver No 34 0.15 0 0 0.0 46
GLDC GLDC P23378 Glycine dehydrogenase (decarboxylating), mitochondrial chr9 GO:0010243 Not Cancer Driver No 152 0.149 112 7 0.062 22
GLP1R GLP1R P43220 Glucagon-like peptide 1 receptor chr6 GO:0010243 Not Cancer Driver No 75 0.162 18 2 0.111 0
GLP2R GLP2R O95838 Glucagon-like peptide 2 receptor chr17 GO:0010243 Not Cancer Driver No 124 0.224 63 14 0.222 0
GLRA1 GLRA1 P23415 Glycine receptor subunit alpha-1 chr5 GO:0010243 Not Cancer Driver No 92 0.201 37 2 0.054 18
GLRA2 GLRA2 P23416 Glycine receptor subunit alpha-2 chrX GO:0010243 Not Cancer Driver No 106 0.235 58 14 0.241 0
GLRA3 GLRA3 O75311 Glycine receptor subunit alpha-3 chr4 GO:0010243 Not Cancer Driver No 132 0.284 32 11 0.344 0
GLRB GLRB P48167 Glycine receptor subunit beta chr4 GO:0010243 Not Cancer Driver No 112 0.225 66 12 0.182 4
GNB1_ENST00000378609 GNB1 P62873 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 chr1 GO:0010243 Not Cancer Driver No 45 0.132 24 2 0.083 16
GNG2_ENST00000615906 GNG2 P59768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 chr14 GO:0010243 Not Cancer Driver No 17 0.239 12 3 0.25 0
GNRHR GNRHR P30968 Gonadotropin-releasing hormone receptor chr4 GO:0010243 Not Cancer Driver No 40 0.122 15 1 0.067 14
GOLPH3 GOLPH3 Q9H4A6 Golgi phosphoprotein 3 chr5 GO:0010243 Not Cancer Driver No 41 0.138 72 1 0.014 0
GPD1 GPD1 P21695 Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic chr12 GO:0010243 Not Cancer Driver No 59 0.169 2 0 0.0 1
GPIHBP1 GPIHBP1 Q8IV16 Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 chr8 GO:0010243 Not Cancer Driver No 26 0.141 82 15 0.183 10
GPI_ENST00000644934 GPI P06744 Glucose-6-phosphate isomerase chr19 GO:0010243 Not Cancer Driver No 77 0.138 73 11 0.151 24
GPR173 GPR173 Q9NS66 Probable G-protein coupled receptor 173 chrX GO:0010243 Not Cancer Driver No 57 0.153 12 0 0.0 0
GPRC6A GPRC6A Q5T6X5 G-protein coupled receptor family C group 6 member A chr6 GO:0010243 Not Cancer Driver No 219 0.237 10 2 0.2 0
GPX1_ENST00000620890 GPX1 P07203 Glutathione peroxidase 1 chr3 GO:0010243 Not Cancer Driver No 38 0.187 12 1 0.083 0
GRIN1_ENST00000371561 GRIN1 Q05586 Glutamate receptor ionotropic, NMDA 1 chr9 GO:0010243 Not Cancer Driver No 88 0.094 190 15 0.079 13
GRIN2A_ENST00000330684 GRIN2A Q12879 Glutamate receptor ionotropic, NMDA 2A chr16 GO:0010243 Census, Compendium Yes 528 0.361 506 207 0.409 31
GRM2 GRM2 Q14416 Metabotropic glutamate receptor 2 chr3 GO:0010243 Not Cancer Driver No 143 0.164 24 3 0.125 0
GRM5 GRM5 P41594 Metabotropic glutamate receptor 5 chr11 GO:0010243 Not Cancer Driver No 312 0.257 323 51 0.158 0
GSK3B_ENST00000264235 GSK3B P49841 Glycogen synthase kinase-3 beta chr3 GO:0010243 Not Cancer Driver No 56 0.133 146 13 0.089 0
GSTM2 GSTM2 P28161 Glutathione S-transferase Mu 2 chr1 GO:0010243 Not Cancer Driver No 26 0.119 5 0 0.0 0
HCN1 HCN1 O60741 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 chr5 GO:0010243 Not Cancer Driver No 432 0.485 365 187 0.512 16
HCN2 HCN2 Q9UL51 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 chr19 GO:0010243 Not Cancer Driver No 75 0.084 342 5 0.015 0
HCN3 HCN3 Q9P1Z3 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 chr1 GO:0010243 Not Cancer Driver No 107 0.138 260 22 0.085 0
HCN4 HCN4 Q9Y3Q4 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 chr15 GO:0010243 Not Cancer Driver No 187 0.155 631 58 0.092 3
HDAC2 HDAC2 Q92769 Histone deacetylase 2 chr6 GO:0010243 Not Cancer Driver No 46 0.094 145 14 0.097 0
HES1 HES1 Q14469 Transcription factor HES-1 chr3 GO:0010243 Not Cancer Driver No 37 0.132 226 32 0.142 0
HLCS HLCS P50747 Biotin--protein ligase chr21 GO:0010243 Not Cancer Driver No 95 0.131 158 15 0.095 23
HMGCS2 HMGCS2 P54868 Hydroxymethylglutaryl-CoA synthase, mitochondrial chr1 GO:0010243 Not Cancer Driver No 92 0.181 29 4 0.138 19
HNRNPAB HNRNPAB Q99729 Heterogeneous nuclear ribonucleoprotein A/B chr5 GO:0010243 Not Cancer Driver No 31 0.093 202 11 0.054 0
HNRNPD HNRNPD Q14103 Heterogeneous nuclear ribonucleoprotein D0 chr4 GO:0010243 Not Cancer Driver No 39 0.11 206 19 0.092 0
HPCA HPCA P84074 Neuron-specific calcium-binding protein hippocalcin chr1 GO:0010243 Not Cancer Driver No 24 0.124 42 4 0.095 3
HPRT1 HPRT1 P00492 Hypoxanthine-guanine phosphoribosyltransferase chrX GO:0010243 Not Cancer Driver No 22 0.101 3 0 0.0 62
HRH1_ENST00000438284 HRH1 P35367 Histamine H1 receptor chr3 GO:0010243 Not Cancer Driver No 96 0.197 122 26 0.213 0
HSF1 HSF1 Q00613 Heat shock factor protein 1 chr8 GO:0010243 Not Cancer Driver No 59 0.112 335 37 0.11 0
HSP90AB1 HSP90AB1 P08238 Heat shock protein HSP 90-beta chr6 GO:0010243 Census, Compendium Yes 100 0.138 254 43 0.169 0
HSP90B1 HSP90B1 P14625 Endoplasmin chr12 GO:0010243 Not Cancer Driver No 94 0.117 268 35 0.131 0
HSPA5 HSPA5 P11021 Endoplasmic reticulum chaperone BiP chr9 GO:0010243 Not Cancer Driver No 73 0.112 282 35 0.124 0
HTR1B HTR1B P28222 5-hydroxytryptamine receptor 1B chr6 GO:0010243 Not Cancer Driver No 91 0.233 33 15 0.455 0
ICAM1 ICAM1 P05362 Intercellular adhesion molecule 1 chr19 GO:0010243 Not Cancer Driver No 61 0.115 251 28 0.112 0
ID1 ID1 P41134 DNA-binding protein inhibitor ID-1 chr20 GO:0010243 Not Cancer Driver No 20 0.129 17 6 0.353 0
IGF1R IGF1R P08069 Insulin-like growth factor 1 receptor chr15 GO:0010243 Not Cancer Driver No 183 0.134 265 37 0.14 6
IGF1_ENST00000307046 IGF1 P05019 Insulin-like growth factor I chr12 GO:0010243 Not Cancer Driver No 45 0.231 87 23 0.264 0
IGFBP5 IGFBP5 P24593 Insulin-like growth factor-binding protein 5 chr2 GO:0010243 Not Cancer Driver No 27 0.099 112 17 0.152 0
IL1A IL1A P01583 Interleukin-1 alpha chr2 GO:0010243 Not Cancer Driver No 30 0.111 35 6 0.171 0
IL1B IL1B P01584 Interleukin-1 beta chr2 GO:0010243 Not Cancer Driver No 39 0.145 16 3 0.188 0
IL6 IL6 P05231 Interleukin-6 chr7 GO:0010243 Not Cancer Driver No 35 0.165 58 7 0.121 0
IMPACT IMPACT Q9P2X3 Protein IMPACT chr18 GO:0010243 Not Cancer Driver No 49 0.153 84 12 0.143 0
INAVA_ENST00000367342 INAVA Q3KP66 Innate immunity activator protein chr1 GO:0010243 Not Cancer Driver No 112 0.169 553 98 0.177 1
INHBB INHBB P09529 Inhibin beta B chain chr2 GO:0010243 Not Cancer Driver No 61 0.15 98 5 0.051 0
INPP5K INPP5K Q9BT40 Inositol polyphosphate 5-phosphatase K chr17 GO:0010243 Not Cancer Driver No 42 0.094 34 2 0.059 7
IPO5_ENST00000490680 IPO5 O00410 Importin-5 chr13 GO:0010243 Not Cancer Driver No 128 0.117 52 3 0.058 0
IRAK3 IRAK3 Q9Y616 Interleukin-1 receptor-associated kinase 3 chr12 GO:0010243 Not Cancer Driver No 103 0.173 79 14 0.177 0
IRF5_ENST00000402030 IRF5 Q13568 Interferon regulatory factor 5 chr7 GO:0010243 Not Cancer Driver No 93 0.187 237 64 0.27 0
ITGA2 ITGA2 P17301 Integrin alpha-2 chr5 GO:0010243 Not Cancer Driver No 166 0.141 26 0 0.0 0
ITGA4 ITGA4 P13612 Integrin alpha-4 chr2 GO:0010243 Not Cancer Driver No 254 0.246 97 27 0.278 0
ITGB1_ENST00000302278 ITGB1 P05556 Integrin beta-1 chr10 GO:0010243 Not Cancer Driver No 103 0.129 84 10 0.119 0
ITGB2_ENST00000355153 ITGB2 P05107 Integrin beta-2 chr21 GO:0010243 Not Cancer Driver No 147 0.191 59 9 0.153 15
ITPR2 ITPR2 Q14571 Inositol 1,4,5-trisphosphate receptor type 2 chr12 GO:0010243 Not Cancer Driver No 359 0.133 394 57 0.145 1
JAG1 JAG1 P78504 Protein jagged-1 chr20 GO:0010243 Not Cancer Driver No 182 0.149 172 20 0.116 52
JAK2 JAK2 O60674 Tyrosine-protein kinase JAK2 chr9 GO:0010243 Census, Compendium Yes 136 0.12 59 5 0.085 5
JUN JUN P05412 Transcription factor Jun chr1 GO:0010243 Census Yes 35 0.106 281 25 0.089 0
JUP JUP P14923 Junction plakoglobin chr17 GO:0010243 Not Cancer Driver No 112 0.15 241 37 0.154 0
KAT7 KAT7 O95251 Histone acetyltransferase KAT7 chr17 GO:0010243 Census Yes 97 0.159 327 47 0.144 0
KCNC1_ENST00000379472 KCNC1 P48547 Potassium voltage-gated channel subfamily C member 1 chr11 GO:0010243 Not Cancer Driver No 91 0.178 110 18 0.164 1
KCNC2 KCNC2 Q96PR1 Potassium voltage-gated channel subfamily C member 2 chr12 GO:0010243 Not Cancer Driver No 161 0.252 255 63 0.247 0
KCNE1_ENST00000399284 KCNE1 P15382 Potassium voltage-gated channel subfamily E member 1 chr21 GO:0010243 Not Cancer Driver No 35 0.271 24 10 0.417 9
KCNJ11 KCNJ11 Q14654 ATP-sensitive inward rectifier potassium channel 11 chr11 GO:0010243 Not Cancer Driver No 48 0.123 19 3 0.158 46
KCNQ1 KCNQ1 P51787 Potassium voltage-gated channel subfamily KQT member 1 chr11 GO:0010243 Not Cancer Driver No 78 0.115 219 20 0.091 132
KDM1A_ENST00000356634 KDM1A O60341 Lysine-specific histone demethylase 1A chr1 GO:0010243 Not Cancer Driver No 67 0.079 291 28 0.096 3
KL KL Q9UEF7 Klotho chr13 GO:0010243 Not Cancer Driver No 175 0.173 104 5 0.048 1
KLF2 KLF2 Q9Y5W3 Krueppel-like factor 2 chr19 GO:0010243 Not Cancer Driver No 13 0.037 280 4 0.014 0
KLHL22 KLHL22 Q53GT1 Kelch-like protein 22 chr22 GO:0010243 Not Cancer Driver No 90 0.142 50 8 0.16 0
KYNU_ENST00000409512 KYNU Q16719 Kynureninase chr2 GO:0010243 Not Cancer Driver No 103 0.222 20 5 0.25 1
LAMTOR1 LAMTOR1 Q6IAA8 Ragulator complex protein LAMTOR1 chr11 GO:0010243 Not Cancer Driver No 13 0.081 96 7 0.073 0
LAMTOR2 LAMTOR2 Q9Y2Q5 Ragulator complex protein LAMTOR2 chr1 GO:0010243 Not Cancer Driver No 12 0.096 0 0 0.0 0
LAMTOR3 LAMTOR3 Q9UHA4 Ragulator complex protein LAMTOR3 chr4 GO:0010243 Not Cancer Driver No 12 0.097 0 0 0.0 0
LAMTOR4 LAMTOR4 Q0VGL1 Ragulator complex protein LAMTOR4 chr7 GO:0010243 Not Cancer Driver No 8 0.081 4 0 0.0 0
LAMTOR5_ENST00000602318 LAMTOR5 O43504 Ragulator complex protein LAMTOR5 chr1 GO:0010243 Not Cancer Driver No 10 0.11 17 0 0.0 0
LARS LARS1 Q9P2J5 Leucine--tRNA ligase, cytoplasmic chr5 GO:0010243 Not Cancer Driver No 133 0.113 97 10 0.103 1
LDLR LDLR P01130 Low-density lipoprotein receptor chr19 GO:0010243 Not Cancer Driver No 119 0.138 63 3 0.048 104
LDOC1 LDOC1 O95751 Protein LDOC1 chrX GO:0010243 Not Cancer Driver No 48 0.329 23 10 0.435 0
LGMN_ENST00000334869 LGMN Q99538 Legumain chr14 GO:0010243 Not Cancer Driver No 57 0.132 112 19 0.17 0
LHCGR LHCGR P22888 Lutropin-choriogonadotropic hormone receptor chr2 GO:0010243 Not Cancer Driver No 181 0.259 12 8 0.667 25
LRP1 LRP1 Q07954 Prolow-density lipoprotein receptor-related protein 1 chr12 GO:0010243 Not Cancer Driver No 664 0.146 317 52 0.164 1
LRRK2 LRRK2 Q5S007 Leucine-rich repeat serine/threonine-protein kinase 2 chr12 GO:0010243 Not Cancer Driver No 519 0.205 90 17 0.189 23
LYN LYN P07948 Tyrosine-protein kinase Lyn chr8 GO:0010243 Census Yes 95 0.186 84 12 0.143 0
MAP1LC3A_ENST00000397709 MAP1LC3A Q9H492 Microtubule-associated proteins 1A/1B light chain 3A chr20 GO:0010243 Not Cancer Driver No 22 0.182 24 1 0.042 0
MAPK13 MAPK13 O15264 Mitogen-activated protein kinase 13 chr6 GO:0010243 Not Cancer Driver No 51 0.14 50 15 0.3 0
MAPK14_ENST00000229794 MAPK14 Q16539 Mitogen-activated protein kinase 14 chr6 GO:0010243 Not Cancer Driver No 39 0.108 25 1 0.04 0
MAPK1_ENST00000398822 MAPK1 P28482 Mitogen-activated protein kinase 1 chr22 GO:0010243 Census, Compendium Yes 62 0.172 2 0 0.0 7
MAPK3 MAPK3 P27361 Mitogen-activated protein kinase 3 chr16 GO:0010243 Not Cancer Driver No 38 0.1 49 5 0.102 0
MC4R MC4R P32245 Melanocortin receptor 4 chr18 GO:0010243 Not Cancer Driver No 57 0.172 2 0 0.0 29
MDM2_ENST00000539479 MDM2 Q00987 E3 ubiquitin-protein ligase Mdm2 chr12 GO:0010243 Census, Compendium Yes 56 0.114 297 37 0.125 0
MEAK7 MEAK7 Q6P9B6 MTOR-associated protein MEAK7 chr16 GO:0010243 Not Cancer Driver No 56 0.123 182 24 0.132 0
MEF2C_ENST00000504921 MEF2C Q06413 Myocyte-specific enhancer factor 2C chr5 GO:0010243 Not Cancer Driver No 92 0.195 408 81 0.199 0
MGARP MGARP Q8TDB4 Protein MGARP chr4 GO:0010243 Not Cancer Driver No 25 0.104 207 22 0.106 0
MIA3 MIA3 Q5JRA6 Transport and Golgi organization protein 1 homolog chr1 GO:0010243 Not Cancer Driver No 222 0.116 1490 178 0.119 0
MMP12 MMP12 P39900 Macrophage metalloelastase chr11 GO:0010243 Not Cancer Driver No 100 0.213 29 5 0.172 0
MMP13 MMP13 P45452 Collagenase 3 chr11 GO:0010243 Not Cancer Driver No 113 0.24 59 16 0.271 5
MMP19 MMP19 Q99542 Matrix metalloproteinase-19 chr12 GO:0010243 Not Cancer Driver No 94 0.185 98 20 0.204 0
MMP2 MMP2 P08253 72 kDa type IV collagenase chr16 GO:0010243 Not Cancer Driver No 123 0.186 29 6 0.207 2
MMP3 MMP3 P08254 Stromelysin-1 chr11 GO:0010243 Not Cancer Driver No 99 0.208 66 14 0.212 0
MMP9 MMP9 P14780 Matrix metalloproteinase-9 chr20 GO:0010243 Not Cancer Driver No 129 0.182 124 26 0.21 0
MRGPRX1 MRGPRX1 Q96LB2 Mas-related G-protein coupled receptor member X1 chr11 GO:0010243 Not Cancer Driver No 123 0.382 0 0 0.0 0
MTHFR_ENST00000376590 MTHFR P42898 Methylenetetrahydrofolate reductase chr1 GO:0010243 Not Cancer Driver No 95 0.145 125 22 0.176 53
MTOR MTOR P42345 Serine/threonine-protein kinase mTOR chr1 GO:0010243 Census, Compendium Yes 379 0.149 296 37 0.125 18
MTRNR2L5 MTRNR2L5 P0CJ72 Humanin-like 5 chr10 GO:0010243 Not Cancer Driver No 1 0.042 0 0 0.0 0
MYC_ENST00000377970 MYC P01106 Myc proto-oncogene protein chr8 GO:0010243 Census, Compendium Yes 80 0.182 299 46 0.154 0
MYD88_ENST00000396334 MYD88 Q99836 Myeloid differentiation primary response protein MyD88 chr3 GO:0010243 Census, Compendium Yes 37 0.125 47 1 0.021 2
NCOR2 NCOR2 Q9Y618 Nuclear receptor corepressor 2 chr12 GO:0010243 Census, Compendium Yes 373 0.148 2355 356 0.151 0
NDUFS4 NDUFS4 O43181 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial chr5 GO:0010243 Not Cancer Driver No 26 0.149 92 17 0.185 1
NEFL NEFL P07196 Neurofilament light polypeptide chr8 GO:0010243 Not Cancer Driver No 92 0.169 285 39 0.137 12
NEURL1 NEURL1 O76050 E3 ubiquitin-protein ligase NEURL1 chr10 GO:0010243 Not Cancer Driver No 62 0.108 153 11 0.072 0
NFE2L2 NFE2L2 Q16236 Nuclear factor erythroid 2-related factor 2 chr2 GO:0010243 Census, Compendium Yes 228 0.377 402 62 0.154 4
NFKB1_ENST00000505458 NFKB1 P19838 Nuclear factor NF-kappa-B p105 subunit chr4 GO:0010243 Not Cancer Driver No 104 0.107 344 38 0.11 0
NFKBIA NFKBIA P25963 NF-kappa-B inhibitor alpha chr14 GO:0010243 Compendium Yes 37 0.117 102 9 0.088 1
NGFR NGFR P08138 Tumor necrosis factor receptor superfamily member 16 chr17 GO:0010243 Not Cancer Driver No 57 0.133 172 25 0.145 0
NGLY1 NGLY1 Q96IV0 Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase chr3 GO:0010243 Not Cancer Driver No 79 0.121 98 13 0.133 0
NLRP1_ENST00000572272 NLRP1 Q9C000 NACHT, LRR and PYD domains-containing protein 1 chr17 GO:0010243 Not Cancer Driver No 222 0.151 340 65 0.191 6
NNMT NNMT P40261 Nicotinamide N-methyltransferase chr11 GO:0010243 Not Cancer Driver No 51 0.193 5 1 0.2 0
NOD1 NOD1 Q9Y239 Nucleotide-binding oligomerization domain-containing protein 1 chr7 GO:0010243 Not Cancer Driver No 130 0.136 38 7 0.184 0
NOD2 NOD2 Q9HC29 Nucleotide-binding oligomerization domain-containing protein 2 chr16 GO:0010243 Not Cancer Driver No 169 0.163 40 4 0.1 15
NOTCH1 NOTCH1 P46531 Neurogenic locus notch homolog protein 1 chr9 GO:0010243 Census, Compendium Yes 363 0.142 686 87 0.127 3
NPC1 NPC1 O15118 NPC intracellular cholesterol transporter 1 chr18 GO:0010243 Not Cancer Driver No 155 0.121 24 0 0.0 150
NQO1 NQO1 P15559 NAD(P)H dehydrogenase [quinone] 1 chr16 GO:0010243 Not Cancer Driver No 21 0.077 10 1 0.1 0
NR4A1_ENST00000394825 NR4A1 P22736 Nuclear receptor subfamily 4 group A member 1 chr12 GO:0010243 Not Cancer Driver No 62 0.104 252 24 0.095 0
NR4A2_ENST00000409572 NR4A2 P43354 Nuclear receptor subfamily 4 group A member 2 chr2 GO:0010243 Not Cancer Driver No 110 0.184 261 38 0.146 0
NR4A3_ENST00000395097 NR4A3 Q92570 Nuclear receptor subfamily 4 group A member 3 chr9 GO:0010243 Census Yes 83 0.133 298 37 0.124 0
NSMF NSMF Q6X4W1 NMDA receptor synaptonuclear signaling and neuronal migration factor chr9 GO:0010243 Not Cancer Driver No 46 0.087 287 19 0.066 2
NTRK1 NTRK1 P04629 High affinity nerve growth factor receptor chr1 GO:0010243 Census, Compendium Yes 168 0.211 57 8 0.14 25
NTRK2_ENST00000323115 NTRK2 Q16620 BDNF/NT-3 growth factors receptor chr9 GO:0010243 Not Cancer Driver No 155 0.189 117 18 0.154 1
OGG1_ENST00000344629 OGG1 O15527 N-glycosylase/DNA lyase chr3 GO:0010243 Not Cancer Driver No 37 0.107 71 12 0.169 0
OPRK1_ENST00000520287 OPRK1 P41145 Kappa-type opioid receptor chr8 GO:0010243 Not Cancer Driver No 117 0.308 18 5 0.278 0
OPRM1_ENST00000330432 OPRM1 P35372 Mu-type opioid receptor chr6 GO:0010243 Not Cancer Driver No 107 0.268 58 27 0.466 0
OTC OTC P00480 Ornithine transcarbamylase, mitochondrial chrX GO:0010243 Not Cancer Driver No 89 0.251 24 4 0.167 111
OXT OXT P01178 Oxytocin-neurophysin 1 chr20 GO:0010243 Not Cancer Driver No 10 0.08 0 0 0.0 0
OXTR OXTR P30559 Oxytocin receptor chr3 GO:0010243 Not Cancer Driver No 46 0.118 18 0 0.0 0
P2RX1 P2RX1 P51575 P2X purinoceptor 1 chr17 GO:0010243 Not Cancer Driver No 59 0.148 14 1 0.071 0
P2RX2_ENST00000643471 P2RX2 Q9UBL9 P2X purinoceptor 2 chr12 GO:0010243 Not Cancer Driver No 62 0.132 104 13 0.125 2
P2RX3 P2RX3 P56373 P2X purinoceptor 3 chr11 GO:0010243 Not Cancer Driver No 85 0.214 15 6 0.4 0
P2RX4_ENST00000337233 P2RX4 Q99571 P2X purinoceptor 4 chr12 GO:0010243 Not Cancer Driver No 36 0.093 0 0 0.0 0
P2RX5 P2RX5 Q93086 P2X purinoceptor 5 chr17 GO:0010243 Not Cancer Driver No 58 0.137 73 14 0.192 0
P2RX6 P2RX6 O15547 P2X purinoceptor 6 chr22 GO:0010243 Not Cancer Driver No 33 0.075 43 1 0.023 0
P2RX7 P2RX7 Q99572 P2X purinoceptor 7 chr12 GO:0010243 Not Cancer Driver No 51 0.086 14 2 0.143 0
P2RY1 P2RY1 P47900 P2Y purinoceptor 1 chr3 GO:0010243 Not Cancer Driver No 60 0.161 16 1 0.062 0
P2RY11 P2RY11 Q96G91 P2Y purinoceptor 11 chr19 GO:0010243 Not Cancer Driver No 47 0.126 31 1 0.032 0
P2RY12 P2RY12 Q9H244 P2Y purinoceptor 12 chr3 GO:0010243 Not Cancer Driver No 57 0.167 21 2 0.095 3
P2RY2_ENST00000393596 P2RY2 P41231 P2Y purinoceptor 2 chr11 GO:0010243 Not Cancer Driver No 67 0.178 60 13 0.217 0
P2RY4 P2RY4 P51582 P2Y purinoceptor 4 chrX GO:0010243 Not Cancer Driver No 66 0.181 10 2 0.2 0
P2RY6_ENST00000540342 P2RY6 Q15077 P2Y purinoceptor 6 chr11 GO:0010243 Not Cancer Driver No 50 0.152 10 5 0.5 0
PANX1 PANX1 Q96RD7 Pannexin-1 chr11 GO:0010243 Not Cancer Driver No 54 0.127 45 7 0.156 2
PARP1 PARP1 P09874 Poly [ADP-ribose] polymerase 1 chr1 GO:0010243 Not Cancer Driver No 119 0.117 320 34 0.106 0
PCK1 PCK1 P35558 Phosphoenolpyruvate carboxykinase, cytosolic [GTP] chr20 GO:0010243 Not Cancer Driver No 142 0.228 110 28 0.255 1
PCNA PCNA P12004 Proliferating cell nuclear antigen chr20 GO:0010243 Not Cancer Driver No 30 0.115 22 3 0.136 1
PCSK1 PCSK1 P29120 Neuroendocrine convertase 1 chr5 GO:0010243 Not Cancer Driver No 139 0.185 336 61 0.182 2
PDE1B PDE1B Q01064 Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B chr12 GO:0010243 Not Cancer Driver No 114 0.213 132 30 0.227 0
PDE2A PDE2A O00408 cGMP-dependent 3',5'-cyclic phosphodiesterase chr11 GO:0010243 Not Cancer Driver No 137 0.146 99 7 0.071 0
PDE3A PDE3A Q14432 cGMP-inhibited 3',5'-cyclic phosphodiesterase A chr12 GO:0010243 Not Cancer Driver No 274 0.24 527 114 0.216 6
PDE4B PDE4B Q07343 cAMP-specific 3',5'-cyclic phosphodiesterase 4B chr1 GO:0010243 Not Cancer Driver No 119 0.162 363 42 0.116 0
PDGFC PDGFC Q9NRA1 Platelet-derived growth factor C chr4 GO:0010243 Not Cancer Driver No 86 0.249 53 12 0.226 0
PDGFD PDGFD Q9GZP0 Platelet-derived growth factor D chr11 GO:0010243 Not Cancer Driver No 85 0.23 37 13 0.351 0
PDGFRA PDGFRA P16234 Platelet-derived growth factor receptor alpha chr4 GO:0010243 Census, Compendium Yes 290 0.266 173 45 0.26 2
PDX1 PDX1 P52945 Pancreas/duodenum homeobox protein 1 chr13 GO:0010243 Not Cancer Driver No 32 0.113 238 23 0.097 0
PDXP PDXP Q96GD0 Chronophin chr22 GO:0010243 Not Cancer Driver No 14 0.047 38 4 0.105 0
PEA15_ENST00000360472 PEA15 Q15121 Astrocytic phosphoprotein PEA-15 chr1 GO:0010243 Not Cancer Driver No 12 0.092 35 5 0.143 0
PENK_ENST00000451791 PENK P01210 Proenkephalin-A chr8 GO:0010243 Not Cancer Driver No 109 0.408 142 62 0.437 0
PER1 PER1 O15534 Period circadian protein homolog 1 chr17 GO:0010243 Census Yes 160 0.124 948 116 0.122 0
PFKFB1 PFKFB1 P16118 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 chrX GO:0010243 Not Cancer Driver No 81 0.172 48 11 0.229 0
PHEX PHEX P78562 Phosphate-regulating neutral endopeptidase PHEX chrX GO:0010243 Not Cancer Driver No 144 0.192 56 7 0.125 30
PIK3C3 PIK3C3 Q8NEB9 Phosphatidylinositol 3-kinase catalytic subunit type 3 chr18 GO:0010243 Not Cancer Driver No 127 0.143 191 34 0.178 0
PIK3CA PIK3CA P42336 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform chr3 GO:0010243 Census, Compendium Yes 1669 1.563 38 11 0.289 30
PIK3CG PIK3CG P48736 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform chr7 GO:0010243 Not Cancer Driver No 318 0.289 121 39 0.322 0
PITX3_ENST00000539804 PITX3 O75364 Pituitary homeobox 3 chr10 GO:0010243 Not Cancer Driver No 24 0.079 155 12 0.077 1
PKD2 PKD2 Q13563 Polycystin-2 chr4 GO:0010243 Not Cancer Driver No 113 0.117 375 35 0.093 10
PKLR PKLR P30613 Pyruvate kinase PKLR chr1 GO:0010243 Not Cancer Driver No 112 0.195 26 5 0.192 101
PLAT PLAT P00750 Tissue-type plasminogen activator chr8 GO:0010243 Not Cancer Driver No 89 0.158 15 2 0.133 0
PLCB1 PLCB1 Q9NQ66 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 chr20 GO:0010243 Not Cancer Driver No 313 0.257 481 104 0.216 0
PNPLA3 PNPLA3 Q9NST1 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 chr22 GO:0010243 Not Cancer Driver No 54 0.112 33 7 0.212 0
PNPT1 PNPT1 Q8TCS8 Polyribonucleotide nucleotidyltransferase 1, mitochondrial chr2 GO:0010243 Not Cancer Driver No 86 0.11 115 10 0.087 2
POMC POMC P01189 Pro-opiomelanocortin chr2 GO:0010243 Not Cancer Driver No 50 0.187 198 38 0.192 0
PPARG PPARG P37231 Peroxisome proliferator-activated receptor gamma chr3 GO:0010243 Census Yes 72 0.143 44 4 0.091 3
PPARGC1B PPARGC1B Q86YN6 Peroxisome proliferator-activated receptor gamma coactivator 1-beta chr5 GO:0010243 Not Cancer Driver No 125 0.122 845 99 0.117 0
PPP1R1B PPP1R1B Q9UD71 Protein phosphatase 1 regulatory subunit 1B chr17 GO:0010243 Not Cancer Driver No 30 0.147 204 30 0.147 0
PPP1R9B PPP1R9B Q96SB3 Neurabin-2 chr17 GO:0010243 Not Cancer Driver No 47 0.058 695 35 0.05 0
PPP2R2A_ENST00000380737 PPP2R2A P63151 Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform chr8 GO:0010243 Not Cancer Driver No 60 0.134 68 10 0.147 0
PPP3CA PPP3CA Q08209 Protein phosphatase 3 catalytic subunit alpha chr4 GO:0010243 Compendium Yes 85 0.163 140 27 0.193 7
PPP5C PPP5C P53041 Serine/threonine-protein phosphatase 5 chr19 GO:0010243 Not Cancer Driver No 70 0.14 73 12 0.164 0
PRKAA1_ENST00000397128 PRKAA1 Q13131 5'-AMP-activated protein kinase catalytic subunit alpha-1 chr5 GO:0010243 Not Cancer Driver No 72 0.129 124 17 0.137 0
PRKACA PRKACA P17612 cAMP-dependent protein kinase catalytic subunit alpha chr19 GO:0010243 Census Yes 53 0.151 24 0 0.0 2
PRKAR2B PRKAR2B P31323 cAMP-dependent protein kinase type II-beta regulatory subunit chr7 GO:0010243 Not Cancer Driver No 60 0.144 125 4 0.032 0
PRKCD_ENST00000330452 PRKCD Q05655 Protein kinase C delta type chr3 GO:0010243 Compendium Yes 79 0.117 43 9 0.209 0
PRKCE PRKCE Q02156 Protein kinase C epsilon type chr2 GO:0010243 Not Cancer Driver No 107 0.145 170 26 0.153 0
PRKCG PRKCG P05129 Protein kinase C gamma type chr19 GO:0010243 Not Cancer Driver No 172 0.247 151 43 0.285 5
PRKN PRKN O60260 E3 ubiquitin-protein ligase parkin chr6 GO:0010243 Not Cancer Driver No 110 0.237 78 15 0.192 31
PRNP PRNP P04156 Major prion protein chr20 GO:0010243 Not Cancer Driver No 36 0.142 115 7 0.061 18
PSEN1 PSEN1 P49768 Presenilin-1 chr14 GO:0010243 Not Cancer Driver No 61 0.131 134 21 0.157 96
PSMB2 PSMB2 P49721 Proteasome subunit beta type-2 chr1 GO:0010243 Not Cancer Driver No 24 0.119 0 0 0.0 0
PTAFR_ENST00000305392 PTAFR P25105 Platelet-activating factor receptor chr1 GO:0010243 Not Cancer Driver No 42 0.123 0 0 0.0 0
PTGS2 PTGS2 P35354 Prostaglandin G/H synthase 2 chr1 GO:0010243 Not Cancer Driver No 105 0.174 30 5 0.167 0
PTK2B_ENST00000346049 PTK2B Q14289 Protein-tyrosine kinase 2-beta chr8 GO:0010243 Not Cancer Driver No 161 0.16 261 37 0.142 0
PTPN22 PTPN22 Q9Y2R2 Tyrosine-protein phosphatase non-receptor type 22 chr1 GO:0010243 Not Cancer Driver No 141 0.175 364 62 0.17 4
RAD51_ENST00000267868 RAD51 Q06609 DNA repair protein RAD51 homolog 1 chr15 GO:0010243 Not Cancer Driver No 42 0.124 47 5 0.106 3
RAMP3 RAMP3 O60896 Receptor activity-modifying protein 3 chr7 GO:0010243 Not Cancer Driver No 30 0.203 0 0 0.0 0
RANGAP1_ENST00000356244 RANGAP1 P46060 Ran GTPase-activating protein 1 chr22 GO:0010243 Not Cancer Driver No 65 0.111 159 17 0.107 0
RAP1A_ENST00000356415 RAP1A P62834 Ras-related protein Rap-1A chr1 GO:0010243 Not Cancer Driver No 27 0.147 5 0 0.0 0
RAP1B_ENST00000393436 RAP1B P61224 Ras-related protein Rap-1b chr12 GO:0010243 Not Cancer Driver No 26 0.141 14 3 0.214 0
RAPGEF1_ENST00000372189 RAPGEF1 Q13905 Rap guanine nucleotide exchange factor 1 chr9 GO:0010243 Not Cancer Driver No 158 0.147 589 87 0.148 0
RAPGEF2 RAPGEF2 Q9Y4G8 Rap guanine nucleotide exchange factor 2 chr4 GO:0010243 Not Cancer Driver No 216 0.144 803 116 0.144 0
RAPGEF3 RAPGEF3 O95398 Rap guanine nucleotide exchange factor 3 chr12 GO:0010243 Not Cancer Driver No 97 0.105 197 19 0.096 0
RECQL5 RECQL5 O94762 ATP-dependent DNA helicase Q5 chr17 GO:0010243 Not Cancer Driver No 132 0.133 495 71 0.143 0
RELA RELA Q04206 Transcription factor p65 chr11 GO:0010243 Compendium Yes 75 0.136 400 48 0.12 0
REN REN P00797 Renin chr1 GO:0010243 Not Cancer Driver No 60 0.148 10 0 0.0 3
RGS2 RGS2 P41220 Regulator of G-protein signaling 2 chr1 GO:0010243 Not Cancer Driver No 30 0.142 50 4 0.08 0
RGS4_ENST00000367909 RGS4 P49798 Regulator of G-protein signaling 4 chr1 GO:0010243 Not Cancer Driver No 68 0.332 5 4 0.8 0
RGS7_ENST00000366563 RGS7 P49802 Regulator of G-protein signaling 7 chr1 GO:0010243 Census, Compendium Yes 196 0.396 150 50 0.333 0
RHOA RHOA P61586 Transforming protein RhoA chr3 GO:0010243 Census, Compendium Yes 99 0.513 46 13 0.283 2
RIPK2 RIPK2 O43353 Receptor-interacting serine/threonine-protein kinase 2 chr8 GO:0010243 Not Cancer Driver No 63 0.117 143 20 0.14 0
RNF185 RNF185 Q96GF1 E3 ubiquitin-protein ligase RNF185 chr22 GO:0010243 Not Cancer Driver No 25 0.13 82 15 0.183 0
RNF5 RNF5 Q99942 E3 ubiquitin-protein ligase RNF5 chr6 GO:0010243 Not Cancer Driver No 17 0.094 69 3 0.043 0
RNLS RNLS Q5VYX0 Renalase chr10 GO:0010243 Not Cancer Driver No 42 0.123 15 1 0.067 0
ROCK1 ROCK1 Q13464 Rho-associated protein kinase 1 chr18 GO:0010243 Not Cancer Driver No 184 0.136 780 103 0.132 0
ROCK2 ROCK2 O75116 Rho-associated protein kinase 2 chr2 GO:0010243 Not Cancer Driver No 145 0.104 732 81 0.111 0
RPL23_ENST00000394332 RPL23 P62829 60S ribosomal protein L23 chr17 GO:0010243 Not Cancer Driver No 14 0.1 29 4 0.138 0
RPS6KB1 RPS6KB1 P23443 Ribosomal protein S6 kinase beta-1 chr17 GO:0010243 Not Cancer Driver No 45 0.086 226 26 0.115 0
RPTOR RPTOR Q8N122 Regulatory-associated protein of mTOR chr17 GO:0010243 Not Cancer Driver No 176 0.132 241 21 0.087 0
RRAGA RRAGA Q7L523 Ras-related GTP-binding protein A chr9 GO:0010243 Not Cancer Driver No 30 0.096 0 0 0.0 0
RRAGB RRAGB Q5VZM2 Ras-related GTP-binding protein B chrX GO:0010243 Not Cancer Driver No 67 0.179 37 5 0.135 0
RRAGC RRAGC Q9HB90 Ras-related GTP-binding protein C chr1 GO:0010243 Compendium Yes 29 0.073 61 1 0.016 0
RRAGD RRAGD Q9NQL2 Ras-related GTP-binding protein D chr6 GO:0010243 Not Cancer Driver No 42 0.105 83 5 0.06 0
RRM2B RRM2B Q7LG56 Ribonucleoside-diphosphate reductase subunit M2 B chr8 GO:0010243 Not Cancer Driver No 46 0.131 32 5 0.156 9
RYR1 RYR1 P21817 Ryanodine receptor 1 chr19 GO:0010243 Not Cancer Driver No 1003 0.199 1186 233 0.196 154
RYR2 RYR2 Q92736 Ryanodine receptor 2 chr1 GO:0010243 Not Cancer Driver No 1703 0.343 782 281 0.359 51
RYR3 RYR3 Q15413 Ryanodine receptor 3 chr15 GO:0010243 Not Cancer Driver No 1079 0.222 649 162 0.25 0
SCNN1A_ENST00000228916 SCNN1A P37088 Amiloride-sensitive sodium channel subunit alpha chr12 GO:0010243 Not Cancer Driver No 73 0.109 146 21 0.144 5
SCNN1B SCNN1B P51168 Amiloride-sensitive sodium channel subunit beta chr16 GO:0010243 Not Cancer Driver No 90 0.141 62 4 0.065 13
SCNN1D SCNN1D P51172 Amiloride-sensitive sodium channel subunit delta chr1 GO:0010243 Not Cancer Driver No 56 0.07 210 9 0.043 0
SCNN1G SCNN1G P51170 Amiloride-sensitive sodium channel subunit gamma chr16 GO:0010243 Not Cancer Driver No 129 0.199 57 11 0.193 0
SDC1_ENST00000254351 SDC1 P18827 Syndecan-1 chr2 GO:0010243 Not Cancer Driver No 31 0.1 259 30 0.116 0
SDF2L1 SDF2L1 Q9HCN8 Stromal cell-derived factor 2-like protein 1 chr22 GO:0010243 Not Cancer Driver No 16 0.072 130 9 0.069 0
SESN1_ENST00000356644 SESN1 Q9Y6P5 Sestrin-1 chr6 GO:0010243 Not Cancer Driver No 45 0.091 48 4 0.083 0
SESN2 SESN2 P58004 Sestrin-2 chr1 GO:0010243 Not Cancer Driver No 74 0.154 147 26 0.177 0
SESN3 SESN3 P58005 Sestrin-3 chr11 GO:0010243 Not Cancer Driver No 84 0.171 44 4 0.091 0
SFRP1 SFRP1 Q8N474 Secreted frizzled-related protein 1 chr8 GO:0010243 Not Cancer Driver No 40 0.127 39 7 0.179 0
SH3BP4_ENST00000392011 SH3BP4 Q9P0V3 SH3 domain-binding protein 4 chr2 GO:0010243 Not Cancer Driver No 143 0.148 241 43 0.178 0
SHMT1 SHMT1 P34896 Serine hydroxymethyltransferase, cytosolic chr17 GO:0010243 Not Cancer Driver No 51 0.106 32 7 0.219 0
SIN3A_ENST00000360439 SIN3A Q96ST3 Paired amphipathic helix protein Sin3a chr15 GO:0010243 Compendium Yes 172 0.135 617 73 0.118 0
SIRT2 SIRT2 Q8IXJ6 NAD-dependent protein deacetylase sirtuin-2 chr19 GO:0010243 Not Cancer Driver No 56 0.144 85 17 0.2 0
SIX1_ENST00000645694 SIX1 Q15475 Homeobox protein SIX1 chr14 GO:0010243 Census, Compendium Yes 49 0.173 144 25 0.174 8
SLC18A2_ENST00000644641 SLC18A2 Q05940 Synaptic vesicular amine transporter chr10 GO:0010243 Not Cancer Driver No 105 0.204 23 7 0.304 1
SLC1A1 SLC1A1 P43005 Excitatory amino acid transporter 3 chr9 GO:0010243 Not Cancer Driver No 69 0.132 17 4 0.235 1
SLC1A2 SLC1A2 P43004 Excitatory amino acid transporter 2 chr11 GO:0010243 Not Cancer Driver No 77 0.134 81 7 0.086 3
SLC1A3 SLC1A3 P43003 Excitatory amino acid transporter 1 chr5 GO:0010243 Not Cancer Driver No 100 0.185 55 9 0.164 1
SLC22A6 SLC22A6 Q4U2R8 Solute carrier family 22 member 6 chr11 GO:0010243 Not Cancer Driver No 85 0.151 72 11 0.153 0
SLC24A4 SLC24A4 Q8NFF2 Sodium/potassium/calcium exchanger 4 chr14 GO:0010243 Not Cancer Driver No 121 0.195 85 14 0.165 2
SLC25A33 SLC25A33 Q9BSK2 Solute carrier family 25 member 33 chr1 GO:0010243 Not Cancer Driver No 23 0.072 4 0 0.0 0
SLC26A3 SLC26A3 P40879 Chloride anion exchanger chr7 GO:0010243 Not Cancer Driver No 159 0.208 3 1 0.333 26
SLC26A6 SLC26A6 Q9BXS9 Solute carrier family 26 member 6 chr3 GO:0010243 Not Cancer Driver No 68 0.09 87 13 0.149 0
SLC30A10 SLC30A10 Q6XR72 Zinc transporter 10 chr1 GO:0010243 Not Cancer Driver No 68 0.14 61 10 0.164 2
SLC34A1 SLC34A1 Q06495 Sodium-dependent phosphate transport protein 2A chr5 GO:0010243 Not Cancer Driver No 92 0.144 46 8 0.174 9
SLC38A9 SLC38A9 Q8NBW4 Sodium-coupled neutral amino acid transporter 9 chr5 GO:0010243 Not Cancer Driver No 57 0.102 33 2 0.061 0
SLC5A5 SLC5A5 Q92911 Sodium/iodide cotransporter chr19 GO:0010243 Not Cancer Driver No 96 0.149 59 7 0.119 5
SLC6A1_ENST00000643498 SLC6A1 P30531 Sodium- and chloride-dependent GABA transporter 1 chr3 GO:0010243 Not Cancer Driver No 119 0.199 24 9 0.375 4
SLC6A3 SLC6A3 Q01959 Sodium-dependent dopamine transporter chr5 GO:0010243 Not Cancer Driver No 150 0.242 31 8 0.258 2
SLC6A4_ENST00000401766 SLC6A4 P31645 Sodium-dependent serotonin transporter chr17 GO:0010243 Not Cancer Driver No 101 0.16 73 12 0.164 0
SLC8A1_ENST00000332839 SLC8A1 P32418 Sodium/calcium exchanger 1 chr2 GO:0010243 Not Cancer Driver No 305 0.313 158 48 0.304 0
SLC9A1 SLC9A1 P19634 Sodium/hydrogen exchanger 1 chr1 GO:0010243 Not Cancer Driver No 89 0.109 251 29 0.116 1
SLIT2 SLIT2 O94813 Slit homolog 2 protein chr4 GO:0010243 Not Cancer Driver No 428 0.28 31 13 0.419 0
SMPD1 SMPD1 P17405 Sphingomyelin phosphodiesterase chr11 GO:0010243 Not Cancer Driver No 93 0.147 51 4 0.078 111
SMPD3 SMPD3 Q9NY59 Sphingomyelin phosphodiesterase 3 chr16 GO:0010243 Not Cancer Driver No 92 0.14 224 29 0.129 0
SNCA_ENST00000506244 SNCA P37840 Alpha-synuclein chr4 GO:0010243 Not Cancer Driver No 21 0.15 107 13 0.121 5
SNX6 SNX6 Q9UNH7 Sorting nexin-6 chr14 GO:0010243 Not Cancer Driver No 33 0.081 85 7 0.082 0
SOCS1 SOCS1 O15524 Suppressor of cytokine signaling 1 chr16 GO:0010243 Census, Compendium Yes 22 0.104 66 3 0.045 2
SOCS5 SOCS5 O75159 Suppressor of cytokine signaling 5 chr2 GO:0010243 Not Cancer Driver No 84 0.157 297 46 0.155 0
SOD1 SOD1 P00441 Superoxide dismutase [Cu-Zn] chr21 GO:0010243 Not Cancer Driver No 16 0.104 93 9 0.097 79
SOX9 SOX9 P48436 Transcription factor SOX-9 chr17 GO:0010243 Compendium Yes 86 0.169 495 82 0.166 18
SPIDR SPIDR Q14159 DNA repair-scaffolding protein chr8 GO:0010243 Not Cancer Driver No 101 0.11 329 20 0.061 0
SRD5A1 SRD5A1 P18405 3-oxo-5-alpha-steroid 4-dehydrogenase 1 chr5 GO:0010243 Not Cancer Driver No 35 0.135 0 0 0.0 0
SREBF1_ENST00000261646 SREBF1 P36956 Sterol regulatory element-binding protein 1 chr17 GO:0010243 Not Cancer Driver No 127 0.111 528 64 0.121 4
SREBF2 SREBF2 Q12772 Sterol regulatory element-binding protein 2 chr22 GO:0010243 Not Cancer Driver No 124 0.109 357 43 0.12 0
SRR SRR Q9GZT4 Serine racemase chr17 GO:0010243 Not Cancer Driver No 40 0.118 32 6 0.188 0
SRSF9 SRSF9 Q13242 Serine/arginine-rich splicing factor 9 chr12 GO:0010243 Not Cancer Driver No 20 0.09 111 8 0.072 0
SSH1 SSH1 Q8WYL5 Protein phosphatase Slingshot homolog 1 chr12 GO:0010243 Not Cancer Driver No 129 0.123 658 85 0.129 0
SST SST P61278 Somatostatin chr3 GO:0010243 Not Cancer Driver No 25 0.216 40 15 0.375 0
ST8SIA2 ST8SIA2 Q92186 Alpha-2,8-sialyltransferase 8B chr15 GO:0010243 Not Cancer Driver No 84 0.224 38 8 0.211 0
STAT1 STAT1 P42224 Signal transducer and activator of transcription 1-alpha/beta chr2 GO:0010243 Not Cancer Driver No 131 0.175 144 25 0.174 26
STC1 STC1 P52823 Stanniocalcin-1 chr8 GO:0010243 Not Cancer Driver No 59 0.239 58 12 0.207 0
STK11 STK11 Q15831 Serine/threonine-protein kinase STK11 chr19 GO:0010243 Census, Compendium Yes 75 0.173 135 14 0.104 9
SYAP1 SYAP1 Q96A49 Synapse-associated protein 1 chrX GO:0010243 Not Cancer Driver No 31 0.088 221 22 0.1 0
SYK_ENST00000375746 SYK P43405 Tyrosine-protein kinase SYK chr9 GO:0010243 Census Yes 96 0.151 131 27 0.206 5
TACR1 TACR1 P25103 Substance-P receptor chr2 GO:0010243 Not Cancer Driver No 69 0.17 28 2 0.071 0
TACR3 TACR3 P29371 Neuromedin-K receptor chr4 GO:0010243 Not Cancer Driver No 137 0.295 31 17 0.548 5
TAF1_ENST00000373790 TAF1 P21675 Transcription initiation factor TFIID subunit 1 chrX GO:0010243 Not Cancer Driver No 379 0.202 1152 219 0.19 5
TAF9 TAF9 Q16594 Transcription initiation factor TFIID subunit 9 chr5 GO:0010243 Not Cancer Driver No 25 0.095 203 19 0.094 0
TGFBR3_ENST00000525962 TGFBR3 Q03167 Transforming growth factor beta receptor type 3 chr1 GO:0010243 Not Cancer Driver No 129 0.152 268 41 0.153 0
TGM2 TGM2 P21980 Protein-glutamine gamma-glutamyltransferase 2 chr20 GO:0010243 Not Cancer Driver No 123 0.179 107 26 0.243 0
TH TH P07101 Tyrosine 3-monooxygenase chr11 GO:0010243 Not Cancer Driver No 61 0.116 149 21 0.141 38
THBD THBD P07204 Thrombomodulin chr20 GO:0010243 Not Cancer Driver No 39 0.068 51 3 0.059 9
TICAM1 TICAM1 Q8IUC6 TIR domain-containing adapter molecule 1 chr19 GO:0010243 Not Cancer Driver No 92 0.129 443 66 0.149 1
TIMELESS TIMELESS Q9UNS1 Protein timeless homolog chr12 GO:0010243 Not Cancer Driver No 154 0.127 367 51 0.139 0
TLR4_ENST00000355622 TLR4 O00206 Toll-like receptor 4 chr9 GO:0010243 Not Cancer Driver No 292 0.348 0 0 0.0 0
TLR6 TLR6 Q9Y2C9 Toll-like receptor 6 chr4 GO:0010243 Not Cancer Driver No 99 0.124 1 0 0.0 0
TMBIM6_ENST00000549385 TMBIM6 P55061 Bax inhibitor 1 chr12 GO:0010243 Not Cancer Driver No 16 0.068 3 0 0.0 0
TMEM38A TMEM38A Q9H6F2 Trimeric intracellular cation channel type A chr19 GO:0010243 Not Cancer Driver No 54 0.181 43 10 0.233 0
TMEM38B TMEM38B Q9NVV0 Trimeric intracellular cation channel type B chr9 GO:0010243 Not Cancer Driver No 47 0.162 37 7 0.189 0
TNF TNF P01375 Tumor necrosis factor chr6 GO:0010243 Not Cancer Driver No 24 0.103 45 3 0.067 0
TNFAIP3 TNFAIP3 P21580 Tumor necrosis factor alpha-induced protein 3 chr6 GO:0010243 Census, Compendium Yes 98 0.124 231 33 0.143 1
TOMM20 TOMM20 Q15388 Mitochondrial import receptor subunit TOM20 homolog chr1 GO:0010243 Not Cancer Driver No 8 0.055 25 1 0.04 0
TOMM70 TOMM70 O94826 Mitochondrial import receptor subunit TOM70 chr3 GO:0010243 Not Cancer Driver No 59 0.097 140 8 0.057 0
TOR1A TOR1A O14656 Torsin-1A chr9 GO:0010243 Not Cancer Driver No 33 0.099 0 0 0.0 3
TP53_ENST00000445888 TP53 P04637 Cellular tumor antigen p53 chr17 GO:0010243 Census, Compendium Yes 2891 7.356 282 1466 5.199 83
TP73 TP73 O15350 Tumor protein p73 chr1 GO:0010243 Not Cancer Driver No 82 0.129 443 55 0.124 0
TRDMT1 TRDMT1 O14717 tRNA (cytosine(38)-C(5))-methyltransferase chr10 GO:0010243 Not Cancer Driver No 65 0.166 19 3 0.158 0
TREM2 TREM2 Q9NZC2 Triggering receptor expressed on myeloid cells 2 chr6 GO:0010243 Not Cancer Driver No 43 0.187 27 2 0.074 1
TRIM16_ENST00000336708 TRIM16 O95361 Tripartite motif-containing protein 16 chr17 GO:0010243 Not Cancer Driver No 64 0.113 132 11 0.083 0
TRIM41 TRIM41 Q8WV44 E3 ubiquitin-protein ligase TRIM41 chr5 GO:0010243 Not Cancer Driver No 69 0.11 385 38 0.099 0
TRPC3_ENST00000264811 TRPC3 Q13507 Short transient receptor potential channel 3 chr4 GO:0010243 Not Cancer Driver No 200 0.239 23 2 0.087 1
TRPM2_ENST00000397928 TRPM2 O94759 Transient receptor potential cation channel subfamily M member 2 chr21 GO:0010243 Not Cancer Driver No 286 0.19 266 44 0.165 0
TRPM4 TRPM4 Q8TD43 Transient receptor potential cation channel subfamily M member 4 chr19 GO:0010243 Not Cancer Driver No 152 0.125 149 18 0.121 12
TRPV1_ENST00000399756 TRPV1 Q8NER1 Transient receptor potential cation channel subfamily V member 1 chr17 GO:0010243 Not Cancer Driver No 93 0.111 155 18 0.116 0
TSHR TSHR P16473 Thyrotropin receptor chr14 GO:0010243 Census Yes 128 0.168 38 9 0.237 39
TSPO_ENST00000329563 TSPO P30536 Translocator protein chr22 GO:0010243 Not Cancer Driver No 5 0.03 1 0 0.0 0
TYMS TYMS P04818 Thymidylate synthase chr18 GO:0010243 Not Cancer Driver No 22 0.07 41 0 0.0 0
TYR TYR P14679 Tyrosinase chr11 GO:0010243 Not Cancer Driver No 156 0.295 52 15 0.288 111
UBE3A UBE3A Q05086 Ubiquitin-protein ligase E3A chr15 GO:0010243 Not Cancer Driver No 141 0.161 136 22 0.162 0
UBR1 UBR1 Q8IWV7 E3 ubiquitin-protein ligase UBR1 chr15 GO:0010243 Not Cancer Driver No 170 0.097 165 15 0.091 18
UBR2 UBR2 Q8IWV8 E3 ubiquitin-protein ligase UBR2 chr6 GO:0010243 Not Cancer Driver No 172 0.098 228 30 0.132 0
UFD1 UFD1 Q92890 Ubiquitin recognition factor in ER-associated degradation protein 1 chr22 GO:0010243 Not Cancer Driver No 26 0.085 100 7 0.07 0
UFL1 UFL1 O94874 E3 UFM1-protein ligase 1 chr6 GO:0010243 Not Cancer Driver No 109 0.137 141 24 0.17 0
UGGT1 UGGT1 Q9NYU2 UDP-glucose:glycoprotein glucosyltransferase 1 chr2 GO:0010243 Not Cancer Driver No 169 0.109 161 20 0.124 0
UGGT2 UGGT2 Q9NYU1 UDP-glucose:glycoprotein glucosyltransferase 2 chr13 GO:0010243 Not Cancer Driver No 190 0.125 64 6 0.094 0
UMODL1_ENST00000408910 UMODL1 Q5DID0 Uromodulin-like 1 chr21 GO:0010243 Not Cancer Driver No 191 0.145 249 29 0.116 0
UQCRC1 UQCRC1 P31930 Cytochrome b-c1 complex subunit 1, mitochondrial chr3 GO:0010243 Not Cancer Driver No 57 0.119 55 6 0.109 2
UROS_ENST00000368786 UROS P10746 Uroporphyrinogen-III synthase chr10 GO:0010243 Not Cancer Driver No 34 0.128 7 0 0.0 21
VCAM1 VCAM1 P19320 Vascular cell adhesion protein 1 chr1 GO:0010243 Not Cancer Driver No 188 0.254 110 28 0.255 0
VCP VCP P55072 Transitional endoplasmic reticulum ATPase chr9 GO:0010243 Not Cancer Driver No 88 0.109 186 16 0.086 16
VGF VGF O15240 Neurosecretory protein VGF chr7 GO:0010243 Not Cancer Driver No 48 0.078 593 47 0.079 0
VIM_ENST00000224237 VIM P08670 Vimentin chr10 GO:0010243 Not Cancer Driver No 84 0.18 316 57 0.18 1
VKORC1 VKORC1 Q9BQB6 Vitamin K epoxide reductase complex subunit 1 chr16 GO:0010243 Not Cancer Driver No 14 0.086 3 0 0.0 19
WNT10B WNT10B O00744 Protein Wnt-10b chr12 GO:0010243 Not Cancer Driver No 56 0.144 84 16 0.19 2
XBP1 XBP1 P17861 X-box-binding protein 1 chr22 GO:0010243 Not Cancer Driver No 19 0.073 169 9 0.053 0
XRN1 XRN1 Q8IZH2 5'-3' exoribonuclease 1 chr3 GO:0010243 Not Cancer Driver No 213 0.125 577 65 0.113 0
ZEB1_ENST00000320985 ZEB1 P37275 Zinc finger E-box-binding homeobox 1 chr10 GO:0010243 Census, Compendium Yes 246 0.219 831 200 0.241 8
ZFP36L1 ZFP36L1 Q07352 mRNA decay activator protein ZFP36L1 chr14 GO:0010243 Compendium Yes 57 0.169 212 30 0.142 0