Uniprot name=
ROCK2
Uniprot Id=
O75116
Chromosome=
chr2
Ensembl Transcript=
ENST00000315872.10
Sequence len=
1388
Name=
Rho-associated protein kinase 2
Rho-associated protein kinase 2
not Cancer Driver
Labels
Structure
ROI
COSMIC iSiMPre
Features
All
Sequence
Complexity
Toggle Dropdown
Complexity SEG
Complexity Dust
Complexity TRF
Exons
OMIM
Polymorphisms
PhastCons
Domains
Structure
Disorder
Toggle Dropdown
Combined
Experimental
AlphaFold
RSA
IUPred
Anchor
Motifs
Toggle Dropdown
ELM Instances
ELM Switches
ScanSite
ClinVar
DIBS
MFIB
Modifications
Uniprot Features
Toggle Dropdown
Region of Interest
Binding regions
Conservations
Toggle Dropdown
Global
Mammalia
Vertebrata
Eumetazoa
Opisthokonta
CoiledCoils
Binding domain
PhaSePro
CBioportal Mutations
Toggle Dropdown
CBioportal Missense
CBioportal Indel
CBioportal Frameshift
COSMIC Mutations
Toggle Dropdown
COSMIC Missense
COSMIC Indel
COSMIC Frameshift
TCGA Mutations
Toggle Dropdown
TCGA Missense
TCGA Indel
TCGA Frameshift
TCGALegacy Mutations
Toggle Dropdown
TCGALegacy Missense
TCGALegacy Indel
TCGALegacy Frameshift
Cancertype
All
BLCA
BRCA
CESC
COAD
ESCA
GBM
HNSC
KICH
KIRC
KIRP
LAML
LGG
LIHC
LUAD
LUSC
OAD
OT
OV
PAAD
PRAD
READ
SARC
SKCM
STAD
THCA
THYM
UCEC
UCS
Summary Table
Driver Prediction
CBioportal
COSMIC
TCGA
TCGALegacy
OMIM
ClinVar
Disorder
Driver Prediction
by 20/20 rule
CBioportal Summary Informations
20%
13.1%
10%
8.46%
6.92%
6.15%
6.15%
5.38%
3.85%
3.85%
3.08%
3.08%
2.31%
2.31%
1.54%
1.54%
0.769%
0.769%
0.769%
SKCM
BLCA
BRCA
LUSC
HNSC
LUAD
UCEC
STAD
CESC
GBM
PRAD
LIHC
COAD
OV
LGG
PAAD
SARC
KIRC
LAML
Missense
plotly-logomark
24.4%
17.1%
14.6%
12.2%
9.76%
4.88%
4.88%
4.88%
4.88%
2.44%
STAD
UCEC
SKCM
BRCA
CESC
LUSC
HNSC
LUAD
COAD
LAML
Frameshift/Nonsense
plotly-logomark
100%
COAD
Indel
plotly-logomark
100%
del
Indels_Ins_Del
plotly-logomark
COSMIC Summary Informations
38.1%
7%
5.84%
5.84%
5.06%
5.06%
3.89%
3.11%
3.11%
3.11%
2.72%
2.72%
2.33%
1.95%
1.95%
1.56%
1.56%
1.17%
1.17%
0.778%
0.778%
0.389%
0.389%
0.389%
OT
LUAD
BLCA
OAD
SKCM
LUSC
COAD
STAD
HNSC
UCEC
BRCA
PRAD
KIRC
CESC
GBM
PAAD
LIHC
READ
OV
LGG
THCA
SARC
LAML
KICH
Missense
plotly-logomark
35.9%
14.1%
10.3%
7.69%
5.13%
5.13%
5.13%
3.85%
2.56%
2.56%
2.56%
1.28%
1.28%
1.28%
1.28%
OT
OAD
SKCM
COAD
CESC
STAD
READ
UCEC
LAML
PRAD
BRCA
LUSC
PAAD
LUAD
KICH
Frameshift/Nonsense
plotly-logomark
COSMIC Indel
data not found for this gene.
COSMIC Indel
data not found for this gene.
TCGA Summary Informations
17.1%
13.3%
8.57%
7.62%
7.62%
6.67%
5.71%
5.71%
4.76%
4.76%
3.81%
3.81%
2.86%
1.9%
1.9%
0.952%
0.952%
0.952%
0.952%
SKCM
BLCA
LUSC
HNSC
UCEC
LUAD
BRCA
STAD
KIRC
CESC
COAD
GBM
OV
LGG
LIHC
READ
PRAD
SARC
LAML
Missense
plotly-logomark
23.8%
19%
14.3%
14.3%
9.52%
9.52%
4.76%
4.76%
SKCM
CESC
READ
UCEC
BRCA
COAD
LUSC
LAML
Frameshift/Nonsense
plotly-logomark
TCGA Indel
data not found for this gene.
TCGA Indel
data not found for this gene.
TCGALegacy Summary Informations
28.5%
11.5%
8.48%
6.67%
5.45%
4.85%
4.85%
4.24%
3.64%
3.64%
3.64%
2.42%
1.82%
1.82%
1.82%
1.21%
1.21%
0.606%
0.606%
0.606%
0.606%
0.606%
0.606%
0.606%
UCEC
SKCM
BLCA
COAD
LUSC
BRCA
HNSC
LUAD
STAD
CESC
READ
GBM
LGG
OV
ESCA
UCS
LIHC
KIRP
PRAD
SARC
THYM
KIRC
LAML
PAAD
Missense
plotly-logomark
34.8%
16.7%
9.09%
7.58%
7.58%
6.06%
4.55%
3.03%
3.03%
1.52%
1.52%
1.52%
1.52%
1.52%
UCEC
STAD
COAD
SKCM
BRCA
CESC
READ
LUSC
UCS
HNSC
LAML
TGCT
LUAD
PCPG
Frameshift/Nonsense
plotly-logomark
TCGALegacy Indel
data not found for this gene.
TCGALegacy Indel
data not found for this gene.
OMIM Summary Informations
OMIM Disease
plotly-logomark
ClinVar Summary Informations
ClinVar Disease
plotly-logomark
Structure Summary Informations
88.4%
11.6%
88.4%
11.6%
Disorder
IUpred
Alpha.
plotly-logomark
Download
Basic
Genome
Comlexity
SNP & Disease
Structure
Disorder
TCGA
COSMIC
Motifs & PTM
Uniprot
Bindings
Phase Separation
Conservation
Sig. Mut.
0
100
200
300
400
500
600
700
800
900
1000
1100
1200
1300
Pkinase
Rho_Binding
Position
?
Sequence
?
Exons
?
PhastCons
?
Complexity-SEG
?
Complexity-DUST
?
Complexity-TRF
?
Polymorphism
?
OMIM Disease Mutations
?
ClinVar
?
CBioportal missense
?
CBioportal indel
?
CBioportal frameshift
?
COSMIC missense
?
COSMIC indel
?
COSMIC frameshift
?
TCGA missense
?
TCGA indel
?
TCGA frameshift
?
TCGALegacy missense
?
TCGALegacy indel
?
TCGALegacy frameshift
?
Domains
?
Structure
?
Combined disorder
?
Exp disorder
?
Alphafold disorder (PLDDT)
?
Alphafold disorder (RSA)
?
IUPred disorder
?
Anchor disorder
?
ELM instances
?
ELM Switches
?
ScanSite
?
PTM
?
Regions of interest
?
Binding regions
?
DIBS
?
MFIB
?
Binding domain
?
PhaSePro
?
Coiled Coils
?
Global
?
Mammalia
?
Vertebrata
?
Eumetazoa
?
Opisthokonta
?
|1
|51
|101
|151
|201
|251
|301
|351
|401
|451
|501
|551
|601
|651
|701
|751
|801
|851
|901
|951
|1001
|1051
|1101
|1151
|1201
|1251
|1301
|1351
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Pkinase
HMM_Acc:
PF00069.28
HMM_Name:
Pkinase
type:
Domain
Position:
92
-
354
select
Rho_Binding
HMM_Acc:
PF08912.14
HMM_Name:
Rho_Binding
type:
Coiled-coil
Position:
978
-
1046
select
PDB structure:
6P5P
Position:
16
-
416
3D Structure
select
PDB structure:
1UIX
Position:
978
-
1046
3D Structure
select
PDB structure:
2ROV
Position:
1150
-
1350
3D Structure
select
PDB structure:
6P5P
Position:
16
-
416
3D Structure
select
PDB structure:
1UIX
Position:
978
-
1046
3D Structure
select
PDB structure:
2ROW
Position:
1236
-
1319
3D Structure
select
PDB structure:
6P5P
Position:
16
-
416
3D Structure
select
PDB structure:
6P5P
Position:
16
-
416
3D Structure
select
PDB structure:
6P5M
Position:
16
-
416
3D Structure
select
PDB structure:
6P5M
Position:
16
-
416
3D Structure
select
PDB structure:
6P5M
Position:
16
-
416
3D Structure
select
PDB structure:
6P5M
Position:
16
-
416
3D Structure
select
PDB structure:
4L6Q
Position:
16
-
416
3D Structure
select
PDB structure:
4L6Q
Position:
16
-
416
3D Structure
select
PDB structure:
2H9V
Position:
16
-
416
3D Structure
select
PDB structure:
2F2U
Position:
16
-
416
3D Structure
select
PDB structure:
2F2U
Position:
16
-
416
3D Structure
select
PDB structure:
7JNT
Position:
18
-
416
3D Structure
select
PDB structure:
7JNT
Position:
18
-
416
3D Structure
select
PDB structure:
7JNT
Position:
18
-
416
3D Structure
select
PDB structure:
7JNT
Position:
18
-
416
3D Structure
select
PDB structure:
7JNT
Position:
18
-
416
3D Structure
select
PDB structure:
7JNT
Position:
18
-
416
3D Structure
select
PDB structure:
7JNT
Position:
18
-
416
3D Structure
select
PDB structure:
7JNT
Position:
18
-
416
3D Structure
select
PDB structure:
4WOT
Position:
21
-
416
3D Structure
select
PDB structure:
4WOT
Position:
21
-
416
3D Structure
select
PDB structure:
4WOT
Position:
21
-
416
3D Structure
select
PDB structure:
4WOT
Position:
21
-
416
3D Structure
select
PDK1_Bind
Name:
PDK1 Binding
Short Name:
PDK1_Bind
Site Sequence:
QLPFIGFtYYRENLL
Site:
T414
Score:
0.2085
Position:
407
-
421
select
Cam_Kin2
Name:
Calmodulin dependent Kinase 2
Short Name:
Cam_Kin2
Site Sequence:
IRIELQMtLDSKDSD
Site:
T1108
Score:
0.3877
Position:
1101
-
1115
select
Itk_SH3
Name:
Itk SH3
Short Name:
Itk_SH3
Site Sequence:
WHMFKPPpALECRRC
Site:
P1289
Score:
0.446
Position:
1282
-
1296
select
p85_SH3_m1
Name:
p85 SH3 mode1
Short Name:
p85_SH3_m1
Site Sequence:
SRLVKKIpKKPPAPD
Site:
P1349
Score:
0.423
Position:
1342
-
1356
select
S
T
K
T
S
K
Y
K
K
S
K
S
Y
K
K
T
T
T
Y
S
K
K
K
T
S
S
S
S
K
S
K
K
K
K
K
S
S
K
T
T
S
T
K
K
K
S
S
K
S
T
Y
S
K
K
Y
S
K
S
T
K
K
S
K
K
T
T
K
K
K
K
K
K
S
Y
S
K
K
K
T
T
K
K
K
S
K
K
K
T
K
K
S
T
K
Y
K
T
S
S
S
S
S
S
S
S
T
S
K
S
S
Y
T
T
Y
K
Y
S
K
Y
K
Y
Y
S
T
T
K
K
K
S
S
T
S
K
S
S
K
K
K
K
K
K
Interaction with PPP1R12A
Note: Interaction with PPP1R12A
Evidence: None
select
RHOA binding
Note: RHOA binding
Evidence:
ECO:0000250
select
Interaction with NPM1
Note: Interaction with NPM1
Evidence:
ECO:0000269
PubMed:17015463
select
K
AlphaFold Structure
CBioportal
COSMIC
TCGA
TCGALegacy
missense
indel
frameshift
color
Information on Sequence
Domains and Motifs
Pfam:
ELM Instances:
ELM Switches:
PTMs
PTM from dbPTM and Phosphosite:
Uniprot Annotations
Region in interest:
Binding Site:
OMIM Disease
OMIM:
Interaction Graph
Full Interaction Table
All Interaction
Intact
Biogrid
Hippie
Interaction with Cancer Drivers
Intact
Biogrid
Hippie