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DHCR24 ,DHCR24 ,Q15392
  • Uniprot Accession= Q15392
  • Ensembl Transcript= ENST00000371269.7
  • Uniprot Name= DHCR24
  • Name= Delta(24)-sterol reductase
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 78
GO term GO name GO namespace GO def
GO:0044281 small molecule metabolic process biological_process The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule. [GOC:curators, GOC:pde, GOC:vw]
GO:0008152 metabolic process biological_process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. [GOC:go_curators, ISBN:0198547684]
GO:0016020 membrane cellular_component A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
GO:0003006 developmental process involved in reproduction biological_process A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring. [GOC:dph, GOC:isa_complete]
GO:0097159 organic cyclic compound binding molecular_function Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure. [GOC:sjw, PMID:7583672]
GO:0048608 reproductive structure development biological_process The reproductive developmental process whose specific outcome is the progression of somatic structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures. [GOC:dph, GOC:isa_complete, GOC:jid]
GO:1901617 organic hydroxy compound biosynthetic process biological_process The chemical reactions and pathways resulting in the formation of organic hydroxy compound. [GOC:pr, GOC:TermGenie]
GO:0031638 zymogen activation biological_process The proteolytic processing of an inactive enzyme to an active form. [GOC:hjd]
GO:0036094 small molecule binding molecular_function Binding to a small molecule, any low molecular weight, monomeric, non-encoded molecule. [GOC:curators, GOC:pde, GOC:pm]
GO:0033218 amide binding molecular_function Binding to an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. [GOC:mah]
GO:1902652 secondary alcohol metabolic process biological_process The chemical reactions and pathways involving secondary alcohol. [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:11288200]
GO:0008202 steroid metabolic process biological_process The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. [ISBN:0198547684]
GO:0043170 macromolecule metabolic process biological_process The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. [GOC:mah]
GO:0046165 alcohol biosynthetic process biological_process The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom. [GOC:ai]
GO:1901564 organonitrogen compound metabolic process biological_process The chemical reactions and pathways involving organonitrogen compound. [GOC:pr, GOC:TermGenie]
GO:0000166 nucleotide binding molecular_function Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. [GOC:mah, ISBN:0198547684]
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors molecular_function Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. [GOC:ai]
GO:0051604 protein maturation biological_process Any process leading to the attainment of the full functional capacity of a protein. [GOC:ai]
GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor molecular_function Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP. [GOC:jl]
GO:1901214 regulation of neuron death biological_process Any process that modulates the frequency, rate or extent of neuron death. [GOC:rph, GOC:TermGenie]
GO:0005634 nucleus cellular_component A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
GO:0000139 Golgi membrane cellular_component The lipid bilayer surrounding any of the compartments of the Golgi apparatus. [GOC:mah]
GO:0006694 steroid biosynthetic process biological_process The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification. [GOC:go_curators]
GO:1901362 organic cyclic compound biosynthetic process biological_process The chemical reactions and pathways resulting in the formation of organic cyclic compound. [GOC:TermGenie]
GO:0005737 cytoplasm cellular_component The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
GO:0005488 binding molecular_function The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. [GOC:ceb, GOC:mah, ISBN:0198506732]
GO:0008104 protein localization biological_process Any process in which a protein is transported to, or maintained in, a specific location. [GOC:ai]
GO:1901360 organic cyclic compound metabolic process biological_process The chemical reactions and pathways involving organic cyclic compound. [GOC:TermGenie]
GO:0008285 negative regulation of cell population proliferation biological_process Any process that stops, prevents or reduces the rate or extent of cell proliferation. [GOC:go_curators]
GO:0043167 ion binding molecular_function Binding to an ion, a charged atoms or groups of atoms. [GOC:jl]
GO:0032502 developmental process biological_process A biological process whose specific outcome is the progression of an integrated living unit
GO:1901265 nucleoside phosphate binding molecular_function Binding to nucleoside phosphate. [GOC:TermGenie]
GO:0016485 protein processing biological_process Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein. [GOC:curators, GOC:jl, GOC:jsg]
GO:0007265 Ras protein signal transduction biological_process A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state. [GOC:bf]
GO:1901576 organic substance biosynthetic process biological_process The chemical reactions and pathways resulting in the formation of an organic substance, any molecular entity containing carbon. [GOC:pr, GOC:TermGenie]
GO:0019538 protein metabolic process biological_process The chemical reactions and pathways involving a protein. Includes protein modification. [GOC:ma]
GO:0050660 flavin adenine dinucleotide binding molecular_function Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. [GOC:ai, GOC:imk, ISBN:0198506732]
GO:0006066 alcohol metabolic process biological_process The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom. [ISBN:0198506732]
GO:0005789 endoplasmic reticulum membrane cellular_component The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]
GO:0009058 biosynthetic process biological_process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. [GOC:curators, ISBN:0198547684]
GO:0003824 catalytic activity molecular_function Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. [GOC:vw, ISBN:0198506732]
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process biological_process Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
GO:0009888 tissue development biological_process The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure. [ISBN:0471245208]
GO:0022414 reproductive process biological_process A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents. [GOC:dph, GOC:isa_complete]
GO:1902653 secondary alcohol biosynthetic process biological_process The chemical reactions and pathways resulting in the formation of secondary alcohol. [GO_REF:0000068, GOC:mengo_curators, GOC:TermGenie, PMID:11288200]
GO:0016021 integral component of membrane cellular_component The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:dos, GOC:go_curators]
GO:0044238 primary metabolic process biological_process The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. [GOC:go_curators, http://www.metacyc.org]
GO:0008203 cholesterol metabolic process biological_process The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues. [ISBN:0198506732]
GO:0006508 proteolysis biological_process The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah]
GO:0016126 sterol biosynthetic process biological_process The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. [GOC:go_curators]
GO:0005829 cytosol cellular_component The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
GO:0019899 enzyme binding molecular_function Binding to an enzyme, a protein with catalytic activity. [GOC:jl]
GO:0006695 cholesterol biosynthetic process biological_process The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:ai]
GO:1901615 organic hydroxy compound metabolic process biological_process The chemical reactions and pathways involving organic hydroxy compound. [GOC:pr, GOC:TermGenie]
GO:0042277 peptide binding molecular_function Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds. [GOC:jl]
GO:0048513 animal organ development biological_process Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. [GOC:dph, GOC:jid]
GO:0043588 skin development biological_process The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue. [GOC:jl, UBERON:0002097]
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0048731 system development biological_process The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. [GOC:dph, GOC:jid]
GO:0006629 lipid metabolic process biological_process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. [GOC:ma]
GO:0044283 small molecule biosynthetic process biological_process The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule. [GOC:curators, GOC:pde, GOC:vw]
GO:0008610 lipid biosynthetic process biological_process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. [GOC:go_curators]
GO:0006979 response to oxidative stress biological_process Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. [GOC:jl, PMID:12115731]
GO:0051726 regulation of cell cycle biological_process Any process that modulates the rate or extent of progression through the cell cycle. [GOC:ai, GOC:dph, GOC:tb]
GO:0016125 sterol metabolic process biological_process The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. [ISBN:0198547684]
GO:0061458 reproductive system development biological_process The progression of the reproductive system over time from its formation to the mature structure. The reproductive system consists of the organs that function in reproduction. [GOC:dph]
GO:0061024 membrane organization biological_process A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. [GOC:dph, GOC:tb]
GO:1901363 heterocyclic compound binding molecular_function Binding to heterocyclic compound. [GOC:TermGenie]
GO:0009725 response to hormone biological_process Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. [GOC:jl]
GO:0043066 negative regulation of apoptotic process biological_process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
GO:0043168 anion binding molecular_function Binding to an anion, a charged atom or group of atoms with a net negative charge. [GOC:jl]
GO:0071704 organic substance metabolic process biological_process The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon. [GOC:mah]
GO:0006807 nitrogen compound metabolic process biological_process The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen. [GOC:jl, ISBN:0198506732]
GO:0016491 oxidoreductase activity molecular_function Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. [GOC:go_curators]
GO:0005856 cytoskeleton cellular_component Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. [GOC:mah, ISBN:0198547684, PMID:16959967]
GO:0005783 endoplasmic reticulum cellular_component The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]
GO:0006915 apoptotic process biological_process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
GO:0048856 anatomical structure development biological_process The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. [GO_REF:0000021]