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MTOR ,MTOR ,P42345
  • Uniprot Accession= P42345
  • Ensembl Transcript= ENST00000361445.8
  • Uniprot Name= MTOR
  • Name= Serine/threonine-protein kinase mTOR
  • Chromosome= chr1
  • Driver status= Census, Compendium
  • Number of Interaction partner in intact: 71
  • Number of Interaction partner in biogrid: 82
  • Number of Interaction partner in hippie: 265
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ABL1_ENST00000318560 ABL1 P00519 Tyrosine-protein kinase ABL1 chr9 Census, Compendium Yes 1 hippie 139 604 73 73 2
AC004754.1 FAM234A B4DGG1 Protein FAM234A chr16 Not Cancer Driver No 1 hippie 56 69 9 9 0
AKT1S1_ENST00000391834 AKT1S1 Q96B36 Proline-rich AKT1 substrate 1 chr19 Not Cancer Driver No 1 hippie 23 256 23 23 0
AKT1_ENST00000349310 AKT1 P31749 RAC-alpha serine/threonine-protein kinase chr14 Census, Compendium Yes 4 intact, hippie 108 158 24 24 4
AMBRA1_ENST00000458649 AMBRA1 Q9C0C7 Activating molecule in BECN1-regulated autophagy protein 1 chr11 Not Cancer Driver No 1 hippie 173 788 103 103 0
APLNR APLNR P35414 Apelin receptor chr11 Not Cancer Driver No 1 hippie, biogrid 96 29 8 8 0
ASPM ASPM Q8IZT6 Abnormal spindle-like microcephaly-associated protein chr1 Not Cancer Driver No 1 intact, hippie 554 424 67 67 0
BAG6 BAG6 P46379 Large proline-rich protein BAG6 chr6 Not Cancer Driver No 1 hippie 98 861 79 79 0
BCAR1_ENST00000162330 BCAR1 P56945 Breast cancer anti-estrogen resistance protein 1 chr16 Not Cancer Driver No 1 hippie 108 677 75 75 0
BCL2L1 BCL2L1 Q07817 Bcl-2-like protein 1 chr20 Not Cancer Driver No 1 hippie 29 55 3 3 0
BECN1_ENST00000590099 BECN1 Q14457 Beclin-1 chr17 Not Cancer Driver No 1 hippie 45 190 19 19 0
BIRC3_ENST00000532808 BIRC3 Q13489 Baculoviral IAP repeat-containing protein 3 chr11 Census, Compendium Yes 1 hippie 77 98 16 16 0
BRAT1 BRAT1 Q6PJG6 BRCA1-associated ATM activator 1 chr7 Not Cancer Driver No 1 hippie 112 101 13 13 0
BRCA1_ENST00000357654 BRCA1 P38398 Breast cancer type 1 susceptibility protein chr17 Census, Compendium Yes 1 hippie 224 1458 174 174 35
BSG BSG P35613 Basigin chr19 Not Cancer Driver No 3 hippie, biogrid 43 123 17 17 0
BTF3 BTF3 P20290 Transcription factor BTF3 chr5 Not Cancer Driver No 1 biogrid 27 192 24 24 0
C3orf18_ENST00000426034 C3orf18 Q9UK00 Uncharacterized protein C3orf18 chr3 Not Cancer Driver No 1 hippie, biogrid 24 111 19 19 0
C7orf25_ENST00000438029 C7orf25 Q9BPX7 UPF0415 protein C7orf25 chr7 Not Cancer Driver No 1 intact, hippie 46 66 7 7 0
CA14 CA14 Q9ULX7 Carbonic anhydrase 14 chr1 Not Cancer Driver No 2 intact, hippie, biogrid 51 104 14 14 0
CACNG4 CACNG4 Q9UBN1 Voltage-dependent calcium channel gamma-4 subunit chr17 Not Cancer Driver No 1 hippie, biogrid 51 71 17 17 0
CCDC167 CCDC167 Q9P0B6 Coiled-coil domain-containing protein 167 chr6 Not Cancer Driver No 1 hippie, biogrid 12 29 3 3 0
CD244 CD244 Q9BZW8 Natural killer cell receptor 2B4 chr1 Not Cancer Driver No 3 intact, hippie, biogrid 77 92 22 22 0
CD274 CD274 Q9NZQ7 Programmed cell death 1 ligand 1 chr9 Census Yes 3 intact, hippie, biogrid 29 54 9 9 0
CD40 CD40 P25942 Tumor necrosis factor receptor superfamily member 5 chr20 Not Cancer Driver No 1 hippie, biogrid 39 56 6 6 2
CD74 CD74 P04233 HLA class II histocompatibility antigen gamma chain chr5 Census Yes 1 hippie 31 185 20 20 0
CD80_ENST00000478182 CD80 P33681 T-lymphocyte activation antigen CD80 chr3 Not Cancer Driver No 1 hippie, biogrid 50 26 5 5 0
CD83 CD83 Q01151 CD83 antigen chr6 Not Cancer Driver No 2 intact, hippie, biogrid 24 48 8 8 0
CDC37 CDC37 Q16543 Hsp90 co-chaperone Cdc37 chr19 Not Cancer Driver No 1 intact, hippie 52 214 31 31 0
CFP CFP P27918 Properdin chrX Not Cancer Driver No 1 hippie 60 48 7 7 6
CFTR CFTR P13569 Cystic fibrosis transmembrane conductance regulator chr7 Not Cancer Driver No 1 hippie 287 145 18 18 151
CHUK CHUK O15111 Inhibitor of nuclear factor kappa-B kinase subunit alpha chr10 Not Cancer Driver No 1 hippie 74 116 9 9 0
CLIP1 CLIP1 P30622 CAP-Gly domain-containing linker protein 1 chr12 Census, Compendium Yes 1 hippie 184 1194 136 136 0
CLN6 CLN6 Q9NWW5 Ceroid-lipofuscinosis neuronal protein 6 chr15 Not Cancer Driver No 1 intact, hippie 28 13 0 0 24
CMAS CMAS Q8NFW8 N-acylneuraminate cytidylyltransferase chr12 Not Cancer Driver No 1 biogrid 49 89 8 8 0
CMKLR1 CMKLR1 Q99788 Chemerin-like receptor 1 chr12 Not Cancer Driver No 1 hippie, biogrid 107 24 13 13 0
COMTD1 COMTD1 Q86VU5 Catechol O-methyltransferase domain-containing protein 1 chr10 Not Cancer Driver No 1 hippie, biogrid 11 23 0 0 0
CUL4A CUL4A Q13619 Cullin-4A chr13 Not Cancer Driver No 1 hippie 64 102 2 2 0
CXCR4_ENST00000241393 CXCR4 P61073 C-X-C chemokine receptor type 4 chr2 Census, Compendium Yes 1 hippie, biogrid 62 5 1 1 0
CYB5B CYB5B O43169 Cytochrome b5 type B chr16 Not Cancer Driver No 1 hippie, biogrid 17 58 2 2 0
DCP2 DCP2 Q8IU60 m7GpppN-mRNA hydrolase chr5 Not Cancer Driver No 1 hippie 57 167 24 24 0
DDB1 DDB1 Q16531 DNA damage-binding protein 1 chr11 Not Cancer Driver No 1 biogrid 126 50 8 8 4
DEPTOR DEPTOR Q8TB45 DEP domain-containing mTOR-interacting protein chr8 Not Cancer Driver No 1 intact, hippie 57 125 12 12 0
DIAPH1 DIAPH1 O60610 Protein diaphanous homolog 1 chr5 Not Cancer Driver No 1 hippie, biogrid 118 692 57 57 1
DPEP1 DPEP1 P16444 Dipeptidase 1 chr16 Not Cancer Driver No 1 hippie, biogrid 54 41 6 6 0
EDEM1 EDEM1 Q92611 ER degradation-enhancing alpha-mannosidase-like protein 1 chr3 Not Cancer Driver No 1 hippie 54 141 5 5 0
EFNA5 EFNA5 P52803 Ephrin-A5 chr5 Not Cancer Driver No 1 hippie, biogrid 34 25 6 6 0
EGFR EGFR P00533 Epidermal growth factor receptor chr7 Census, Compendium Yes 1 hippie 444 223 35 35 1
EIF3B_ENST00000397011 EIF3B P55884 Eukaryotic translation initiation factor 3 subunit B chr7 Not Cancer Driver No 1 hippie 89 226 4 4 0
EIF3C EIF3C Q99613 Eukaryotic translation initiation factor 3 subunit C chr16 Not Cancer Driver No 1 hippie 15 391 12 12 0
EIF3D EIF3D O15371 Eukaryotic translation initiation factor 3 subunit D chr22 Not Cancer Driver No 1 biogrid 63 200 26 26 0
EIF3F_ENST00000309828 EIF3F O00303 Eukaryotic translation initiation factor 3 subunit F chr11 Not Cancer Driver No 1 hippie 29 125 8 8 1
EIF4EBP1 EIF4EBP1 Q13541 Eukaryotic translation initiation factor 4E-binding protein 1 chr8 Not Cancer Driver No 1 hippie 8 118 8 8 0
EIF4EBP2 EIF4EBP2 Q13542 Eukaryotic translation initiation factor 4E-binding protein 2 chr10 Not Cancer Driver No 1 hippie 17 118 14 14 0
EIF4E_ENST00000450253 EIF4E P06730 Eukaryotic translation initiation factor 4E chr4 Not Cancer Driver No 1 hippie 26 54 6 6 0
EP300 EP300 Q09472 Histone acetyltransferase p300 chr22 Census, Compendium Yes 1 hippie 334 1790 196 196 1
ESR1_ENST00000206249 ESR1 P03372 Estrogen receptor chr6 Census, Compendium Yes 1 hippie 121 195 27 27 2
FAM174A FAM174A Q8TBP5 Membrane protein FAM174A chr5 Not Cancer Driver No 1 hippie, biogrid 27 140 21 21 0
FAM234A_ENST00000301678 FAM234A Q9H0X4 Protein FAM234A chr16 Not Cancer Driver No 1 hippie 60 99 11 11 0
FBXO8 FBXO8 Q9NRD0 F-box only protein 8 chr4 Not Cancer Driver No 1 hippie 46 25 1 1 0
FBXO9 FBXO9 Q9UK97 F-box only protein 9 chr6 Not Cancer Driver No 1 intact, hippie 49 110 7 7 0
FBXW7_ENST00000603841 FBXW7 Q969H0 F-box/WD repeat-containing protein 7 chr4 Census, Compendium Yes 1 hippie 322 230 38 38 0
FKBP1A FKBP1A P62942 Peptidyl-prolyl cis-trans isomerase FKBP1A chr20 Not Cancer Driver No 5 intact, hippie, biogrid 15 39 7 7 0
FKBP8_ENST00000222308 FKBP8 Q14318 Peptidyl-prolyl cis-trans isomerase FKBP8 chr19 Not Cancer Driver No 1 hippie 71 160 25 25 0
FPR1_ENST00000304748 FPR1 P21462 fMet-Leu-Phe receptor chr19 Not Cancer Driver No 1 hippie, biogrid 99 18 3 3 0
GADD45A GADD45A P24522 Growth arrest and DNA damage-inducible protein GADD45 alpha chr1 Not Cancer Driver No 1 hippie 10 39 5 5 0
GFI1B GFI1B Q5VTD9 Zinc finger protein Gfi-1b chr9 Not Cancer Driver No 1 biogrid 50 142 23 23 0
GNB1_ENST00000378609 GNB1 P62873 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 chr1 Not Cancer Driver No 1 hippie 45 24 2 2 16
GNB2 GNB2 P62879 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 chr7 Not Cancer Driver No 1 hippie 50 21 0 0 7
GNB3 GNB3 P16520 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 chr12 Not Cancer Driver No 1 hippie 51 13 1 1 0
GNB5 GNB5 O14775 Guanine nucleotide-binding protein subunit beta-5 chr15 Not Cancer Driver No 1 hippie 60 16 1 1 1
GNG2_ENST00000615906 GNG2 P59768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 chr14 Not Cancer Driver No 1 hippie 17 12 3 3 0
GPHN_ENST00000315266 GPHN Q9NQX3 Gephyrin chr14 Census Yes 1 hippie 126 305 41 41 2
GPR17 GPR17 Q13304 Uracil nucleotide/cysteinyl leukotriene receptor chr2 Not Cancer Driver No 1 hippie, biogrid 57 16 4 4 0
GPR182 GPR182 O15218 G-protein coupled receptor 182 chr12 Not Cancer Driver No 1 hippie, biogrid 49 33 4 4 0
GPR45 GPR45 Q9Y5Y3 Probable G-protein coupled receptor 45 chr2 Not Cancer Driver No 1 hippie, biogrid 97 0 0 0 0
GPR55 GPR55 Q9Y2T6 G-protein coupled receptor 55 chr2 Not Cancer Driver No 1 hippie, biogrid 64 0 0 0 0
GSK3B_ENST00000264235 GSK3B P49841 Glycogen synthase kinase-3 beta chr3 Not Cancer Driver No 1 intact, hippie 56 146 13 13 0
GTF3C1 GTF3C1 Q12789 General transcription factor 3C polypeptide 1 chr16 Not Cancer Driver No 1 hippie 323 735 114 114 0
GTF3C2 GTF3C2 Q8WUA4 General transcription factor 3C polypeptide 2 chr2 Not Cancer Driver No 1 intact, hippie 111 394 45 45 0
GTF3C5_ENST00000372097 GTF3C5 Q9Y5Q8 General transcription factor 3C polypeptide 5 chr9 Not Cancer Driver No 1 hippie 75 157 21 21 0
GYPA_ENST00000360771 GYPA P02724 Glycophorin-A chr4 Not Cancer Driver No 1 hippie, biogrid 46 94 31 31 0
HCST HCST Q9UBK5 Hematopoietic cell signal transducer chr19 Not Cancer Driver No 1 hippie, biogrid 6 12 0 0 0
HIF1A_ENST00000337138 HIF1A Q16665 Hypoxia-inducible factor 1-alpha chr14 Census Yes 1 hippie 118 435 51 51 0
HNRNPD HNRNPD Q14103 Heterogeneous nuclear ribonucleoprotein D0 chr4 Not Cancer Driver No 1 intact, hippie 39 206 19 19 0
HRAS HRAS P01112 GTPase HRas chr11 Census, Compendium Yes 1 hippie 107 16 4 4 18
HSP90AA1_ENST00000216281 HSP90AA1 P07900 Heat shock protein HSP 90-alpha chr14 Census, Compendium Yes 1 biogrid 106 257 37 37 0
HSP90AB1 HSP90AB1 P08238 Heat shock protein HSP 90-beta chr6 Census, Compendium Yes 1 biogrid 100 254 43 43 0
HSPA4 HSPA4 P34932 Heat shock 70 kDa protein 4 chr5 Not Cancer Driver No 1 hippie 80 351 24 24 0
HTR6 HTR6 P50406 5-hydroxytryptamine receptor 6 chr1 Not Cancer Driver No 1 hippie 78 136 27 27 0
HTT HTT P42858 Huntingtin chr4 Not Cancer Driver No 1 hippie 336 666 69 69 2
IKBKB IKBKB O14920 Inhibitor of nuclear factor kappa-B kinase subunit beta chr8 Census, Compendium Yes 1 hippie 106 211 31 31 1
IKBKG_ENST00000611071 IKBKG Q9Y6K9 NF-kappa-B essential modulator chrX Not Cancer Driver No 1 hippie 6 301 6 6 22
ILK_ENST00000299421 ILK Q13418 Integrin-linked protein kinase chr11 Not Cancer Driver No 1 hippie 45 71 9 9 0
ILVBL ILVBL A1L0T0 2-hydroxyacyl-CoA lyase 2 chr19 Not Cancer Driver No 1 hippie, biogrid 86 30 1 1 0
IRS1 IRS1 P35568 Insulin receptor substrate 1 chr2 Not Cancer Driver No 1 hippie 161 1072 133 133 2
IRS2 IRS2 Q9Y4H2 Insulin receptor substrate 2 chr13 Not Cancer Driver No 1 hippie 69 1112 57 57 0
ISLR ISLR O14498 Immunoglobulin superfamily containing leucine-rich repeat protein chr15 Not Cancer Driver No 1 hippie, biogrid 83 87 13 13 0
KRAS KRAS P01116 GTPase KRas chr12 Census, Compendium Yes 2 hippie, biogrid 788 7 2 2 27
LAMP1 LAMP1 P11279 Lysosome-associated membrane glycoprotein 1 chr13 Not Cancer Driver No 1 hippie 47 93 10 10 0
LAMP2_ENST00000200639 LAMP2 P13473 Lysosome-associated membrane glycoprotein 2 chrX Not Cancer Driver No 1 hippie 43 55 7 7 1
LAMTOR1 LAMTOR1 Q6IAA8 Ragulator complex protein LAMTOR1 chr11 Not Cancer Driver No 1 intact, hippie 13 96 7 7 0
LAMTOR2 LAMTOR2 Q9Y2Q5 Ragulator complex protein LAMTOR2 chr1 Not Cancer Driver No 1 intact, hippie 12 0 0 0 0
LAMTOR4 LAMTOR4 Q0VGL1 Ragulator complex protein LAMTOR4 chr7 Not Cancer Driver No 1 intact, hippie 8 4 0 0 0
LAMTOR5_ENST00000602318 LAMTOR5 O43504 Ragulator complex protein LAMTOR5 chr1 Not Cancer Driver No 1 intact, hippie 10 17 0 0 0
LANCL2 LANCL2 Q9NS86 LanC-like protein 2 chr7 Not Cancer Driver No 1 hippie 71 44 5 5 0
LARP1 LARP1 Q6PKG0-3 Isoform 2 of La-related protein 1 chr5 Not Cancer Driver No 1 hippie 136 726 100 100 0
LARS LARS1 Q9P2J5 Leucine--tRNA ligase, cytoplasmic chr5 Not Cancer Driver No 1 intact 133 97 10 10 1
LEFTY1 LEFTY1 O75610 Left-right determination factor 1 chr1 Not Cancer Driver No 2 hippie, biogrid 55 65 8 8 0
LLGL2 LLGL2 Q6P1M3 LLGL scribble cell polarity complex component 2 chr17 Not Cancer Driver No 1 intact, hippie 120 266 26 26 0
LMBR1L LMBR1L Q6UX01 Protein LMBR1L chr12 Not Cancer Driver No 1 hippie 57 4 0 0 0
LNPK_ENST00000272748 LNPK Q9C0E8 Endoplasmic reticulum junction formation protein lunapark chr2 Not Cancer Driver No 1 hippie 62 257 43 43 0
LRPAP1 LRPAP1 P30533 Alpha-2-macroglobulin receptor-associated protein chr4 Not Cancer Driver No 1 hippie 41 188 20 20 0
LRRC25_ENST00000595840 LRRC25 Q8N386 Leucine-rich repeat-containing protein 25 chr19 Not Cancer Driver No 1 hippie, biogrid 40 89 14 14 0
LRRC31 LRRC31 Q6UY01 Leucine-rich repeat-containing protein 31 chr3 Not Cancer Driver No 1 hippie 109 80 10 10 0
LRRK2 LRRK2 Q5S007 Leucine-rich repeat serine/threonine-protein kinase 2 chr12 Not Cancer Driver No 1 intact, hippie 519 90 17 17 23
LYPD3 LYPD3 O95274 Ly6/PLAUR domain-containing protein 3 chr19 Not Cancer Driver No 3 intact, hippie, biogrid 52 116 15 15 0
MAF1_ENST00000532522 MAF1 Q9H063 Repressor of RNA polymerase III transcription MAF1 homolog chr8 Not Cancer Driver No 1 intact, hippie 22 74 4 4 0
MAP3K3_ENST00000361733 MAP3K3 Q99759 Mitogen-activated protein kinase kinase kinase 3 chr17 Not Cancer Driver No 1 hippie 74 355 44 44 0
MAPK8_ENST00000374189 MAPK8 P45983 Mitogen-activated protein kinase 8 chr10 Not Cancer Driver No 1 hippie 64 94 9 9 0
MAPKAP1 MAPKAP1 Q9BPZ7 Target of rapamycin complex 2 subunit MAPKAP1 chr9 Not Cancer Driver No 2 hippie, biogrid 70 173 25 25 0
MAX MAX P61244 Protein max chr14 Census, Compendium Yes 1 biogrid 45 160 45 45 9
MCAM MCAM P43121 Cell surface glycoprotein MUC18 chr11 Not Cancer Driver No 1 hippie 91 305 46 46 0
MDM4 MDM4 O15151 Protein Mdm4 chr1 Census, Compendium Yes 1 hippie 57 202 26 26 1
METAP2 METAP2 P50579 Methionine aminopeptidase 2 chr12 Not Cancer Driver No 1 hippie 54 176 19 19 0
MFSD4A MFSD4A Q8N468 Major facilitator superfamily domain-containing protein 4A chr1 Not Cancer Driver No 1 hippie 56 29 3 3 0
MICA_ENST00000616296 MICA A0A024RCL3 MHC class I polypeptide-related sequence A chr6 Not Cancer Driver No 1 biogrid 37 49 8 8 0
MKRN2 MKRN2 Q9H000 E3 ubiquitin-protein ligase makorin-2 chr3 Not Cancer Driver No 1 hippie 45 145 16 16 0
MLST8_ENST00000397124 MLST8 Q9BVC4 Target of rapamycin complex subunit LST8 chr16 Not Cancer Driver No 10 intact, hippie, biogrid 37 45 3 3 0
MLXIP MLXIP Q9HAP2 MLX-interacting protein chr12 Not Cancer Driver No 1 hippie 85 578 42 42 0
MLXIPL MLXIPL Q9NP71 Carbohydrate-responsive element-binding protein chr7 Not Cancer Driver No 1 hippie 106 554 66 66 0
MOV10_ENST00000357443 MOV10 Q9HCE1 Helicase MOV-10 chr1 Not Cancer Driver No 1 hippie 110 101 8 8 0
MRPL13 MRPL13 Q9BYD1 39S ribosomal protein L13, mitochondrial chr8 Not Cancer Driver No 1 biogrid 28 10 1 1 0
MRPL19_ENST00000409374 MRPL19 P49406 39S ribosomal protein L19, mitochondrial chr2 Not Cancer Driver No 1 biogrid 22 63 4 4 0
MRPS5 MRPS5 P82675 28S ribosomal protein S5, mitochondrial chr2 Not Cancer Driver No 1 biogrid 52 157 20 20 0
MTA2 MTA2 O94776 Metastasis-associated protein MTA2 chr11 Not Cancer Driver No 1 hippie 78 283 32 32 0
MTMR3 MTMR3 Q13615 Myotubularin-related protein 3 chr22 Not Cancer Driver No 1 intact, hippie 130 501 66 66 0
MTOR MTOR P42345 Serine/threonine-protein kinase mTOR chr1 Census, Compendium Yes 5 intact, hippie, biogrid 379 296 37 37 18
NAF1 NAF1 Q96HR8 H/ACA ribonucleoprotein complex non-core subunit NAF1 chr4 Not Cancer Driver No 1 intact, hippie 61 386 44 44 0
NBN NBN O60934 Nibrin chr8 Census Yes 1 hippie 90 417 54 54 1
NCBP1 NCBP1 Q09161 Nuclear cap-binding protein subunit 1 chr9 Not Cancer Driver No 1 intact, hippie 88 89 8 8 0
NDUFA8 NDUFA8 P51970 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 chr9 Not Cancer Driver No 1 biogrid 25 33 1 1 2
NDUFA9 NDUFA9 Q16795 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial chr12 Not Cancer Driver No 1 biogrid 57 8 0 0 2
NDUFB2_ENST00000247866 NDUFB2 O95178 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial chr7 Not Cancer Driver No 1 biogrid 13 26 3 3 0
NFKBIA NFKBIA P25963 NF-kappa-B inhibitor alpha chr14 Compendium Yes 1 hippie 37 102 9 9 1
NPTN NPTN Q9Y639 Neuroplastin chr15 Not Cancer Driver No 1 hippie, biogrid 47 118 9 9 0
NPY2R NPY2R P49146 Neuropeptide Y receptor type 2 chr4 Not Cancer Driver No 2 intact, hippie, biogrid 119 53 16 16 0
NRAS NRAS P01111 GTPase NRas chr1 Census, Compendium Yes 1 hippie 284 10 0 0 14
NT5E NT5E P21589 5'-nucleotidase chr6 Not Cancer Driver No 3 intact, hippie, biogrid 61 26 2 2 1
NTRK3_ENST00000629765 NTRK3 Q16288 NT-3 growth factor receptor chr15 Census, Compendium Yes 2 intact, hippie, biogrid 249 57 21 21 0
NXF1_ENST00000294172 NXF1 Q9UBU9 Nuclear RNA export factor 1 chr11 Compendium Yes 1 hippie 100 163 32 32 0
OPALIN OPALIN Q96PE5 Opalin chr10 Not Cancer Driver No 1 hippie, biogrid 29 86 18 18 0
P2RY6_ENST00000540342 P2RY6 Q15077 P2Y purinoceptor 6 chr11 Not Cancer Driver No 1 intact, hippie 50 10 5 5 0
P2RY8 P2RY8 Q86VZ1 P2Y purinoceptor 8 chrX Census, Compendium Yes 1 hippie, biogrid 126 23 5 5 0
PA2G4 PA2G4 Q9UQ80 Proliferation-associated protein 2G4 chr12 Not Cancer Driver No 1 hippie 45 128 18 18 0
PCNA PCNA P12004 Proliferating cell nuclear antigen chr20 Not Cancer Driver No 1 hippie 30 22 3 3 1
PDIA3 PDIA3 P30101 Protein disulfide-isomerase A3 chr15 Not Cancer Driver No 1 hippie 57 98 11 11 0
PDK1_ENST00000282077 PDK1 Q15118 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial chr2 Not Cancer Driver No 1 hippie 52 50 10 10 0
PDPK1 PDPK1 O15530 3-phosphoinositide-dependent protein kinase 1 chr16 Not Cancer Driver No 1 intact, hippie 33 121 12 12 0
PGRMC1 PGRMC1 O00264 Membrane-associated progesterone receptor component 1 chrX Not Cancer Driver No 1 hippie 30 74 16 16 0
PIH1D1 PIH1D1 Q9NWS0 PIH1 domain-containing protein 1 chr19 Not Cancer Driver No 1 intact, hippie 30 157 13 13 0
PIK3C3 PIK3C3 Q8NEB9 Phosphatidylinositol 3-kinase catalytic subunit type 3 chr18 Not Cancer Driver No 1 hippie 127 191 34 34 0
PIK3R4 PIK3R4 Q99570 Phosphoinositide 3-kinase regulatory subunit 4 chr3 Not Cancer Driver No 1 hippie 193 315 45 45 0
PLD2 PLD2 O14939 Phospholipase D2 chr17 Not Cancer Driver No 1 hippie 107 97 8 8 0
PLEKHA4 PLEKHA4 Q9H4M7 Pleckstrin homology domain-containing family A member 4 chr19 Not Cancer Driver No 1 hippie 136 687 128 128 0
PLEKHM1 PLEKHM1 Q9Y4G2 Pleckstrin homology domain-containing family M member 1 chr17 Not Cancer Driver No 1 intact 140 373 55 55 0
PML PML P29590 Protein PML chr15 Census, Compendium Yes 1 hippie 112 312 34 34 0
PPP2R2A_ENST00000380737 PPP2R2A P63151 Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform chr8 Not Cancer Driver No 1 hippie 60 68 10 10 0
PREX1 PREX1 Q8TCU6 Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein chr20 Not Cancer Driver No 1 intact, hippie 297 307 55 55 0
PREX2 PREX2 Q70Z35 Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein chr8 Census, Compendium Yes 1 intact, hippie 492 234 68 68 0
PRKAA1_ENST00000397128 PRKAA1 Q13131 5'-AMP-activated protein kinase catalytic subunit alpha-1 chr5 Not Cancer Driver No 1 hippie 72 124 17 17 0
PRKAR1A_ENST00000536854 PRKAR1A P10644 cAMP-dependent protein kinase type I-alpha regulatory subunit chr17 Census, Compendium Yes 1 hippie 39 66 11 11 17
PRKCA PRKCA P17252 Protein kinase C alpha type chr17 Not Cancer Driver No 1 hippie 94 154 22 22 0
PRKCD_ENST00000330452 PRKCD Q05655 Protein kinase C delta type chr3 Compendium Yes 1 hippie 79 43 9 9 0
PRKDC PRKDC P78527 DNA-dependent protein kinase catalytic subunit chr8 Not Cancer Driver No 1 intact, hippie 538 421 61 61 2
PRKN PRKN O60260 E3 ubiquitin-protein ligase parkin chr6 Not Cancer Driver No 1 hippie 110 78 15 15 31
PRR5L PRR5L Q6MZQ0 Proline-rich protein 5-like chr11 Not Cancer Driver No 1 hippie 57 108 12 12 0
PRR5_ENST00000336985 PRR5 P85299 Proline-rich protein 5 chr22 Not Cancer Driver No 1 intact, hippie 50 173 22 22 0
PSMC5 PSMC5 P62195 26S proteasome regulatory subunit 8 chr17 Not Cancer Driver No 1 biogrid 52 64 6 6 0
PSMC6_ENST00000606149 PSMC6 P62333 26S proteasome regulatory subunit 10B chr14 Not Cancer Driver No 1 biogrid 49 69 8 8 0
PSMD14 PSMD14 O00487 26S proteasome non-ATPase regulatory subunit 14 chr2 Not Cancer Driver No 1 biogrid 23 67 6 6 0
RAB1A RAB1A P62820 Ras-related protein Rab-1A chr2 Not Cancer Driver No 1 hippie 16 38 2 2 0
RAC1_ENST00000348035 RAC1 P63000 Ras-related C3 botulinum toxin substrate 1 chr7 Census, Compendium Yes 1 hippie 66 2 1 1 6
RAC2 RAC2 P15153 Ras-related C3 botulinum toxin substrate 2 chr22 Not Cancer Driver No 1 hippie 31 0 0 0 2
RACK1 RACK1 P63244 Receptor of activated protein C kinase 1 chr5 Not Cancer Driver No 1 hippie 34 13 0 0 0
RAP1A_ENST00000356415 RAP1A P62834 Ras-related protein Rap-1A chr1 Not Cancer Driver No 1 hippie 27 5 0 0 0
RAP2A RAP2A P10114 Ras-related protein Rap-2a chr13 Not Cancer Driver No 1 hippie 15 9 0 0 0
RHEB RHEB Q15382 GTP-binding protein Rheb chr7 Not Cancer Driver No 1 hippie 30 0 0 0 0
RHEBL1 RHEBL1 Q8TAI7 GTPase RhebL1 chr12 Not Cancer Driver No 1 hippie 15 5 0 0 0
RHOD RHOD O00212 Rho-related GTP-binding protein RhoD chr11 Not Cancer Driver No 1 hippie 20 10 0 0 0
RHOF RHOF Q9HBH0 Rho-related GTP-binding protein RhoF chr12 Not Cancer Driver No 1 hippie 18 10 0 0 0
RHOG_ENST00000396978 RHOG P84095 Rho-related GTP-binding protein RhoG chr11 Not Cancer Driver No 1 hippie 26 22 5 5 0
RHOH_ENST00000617441 RHOH Q15669 Rho-related GTP-binding protein RhoH chr4 Census Yes 1 hippie 41 12 3 3 0
RHOJ RHOJ Q9H4E5 Rho-related GTP-binding protein RhoJ chr14 Not Cancer Driver No 1 hippie 39 0 0 0 0
RHOQ RHOQ P17081 Rho-related GTP-binding protein RhoQ chr2 Not Cancer Driver No 1 hippie 25 0 0 0 0
RHOV RHOV Q96L33 Rho-related GTP-binding protein RhoV chr15 Not Cancer Driver No 1 hippie 25 47 5 5 0
RICTOR_ENST00000357387 RICTOR Q6R327 Rapamycin-insensitive companion of mTOR chr5 Not Cancer Driver No 15 intact, hippie 212 366 50 50 0
RNF126 RNF126 Q9BV68 E3 ubiquitin-protein ligase RNF126 chr19 Not Cancer Driver No 1 hippie 33 182 22 22 0
RP2 RP2 O75695 Protein XRP2 chrX Not Cancer Driver No 3 intact, hippie, biogrid 45 28 6 6 10
RPL23A RPL23A P62750 60S ribosomal protein L23a chr17 Not Cancer Driver No 1 hippie 21 70 13 13 0
RPL23_ENST00000394332 RPL23 P62829 60S ribosomal protein L23 chr17 Not Cancer Driver No 1 hippie 14 29 4 4 0
RPL26 RPL26 P61254 60S ribosomal protein L26 chr17 Not Cancer Driver No 1 intact, hippie 16 114 13 13 0
RPL5_ENST00000370321 RPL5 P46777 60S ribosomal protein L5 chr1 Census Yes 1 hippie 57 96 17 17 2
RPL7 RPL7 P18124 60S ribosomal protein L7 chr8 Not Cancer Driver No 1 intact, hippie 24 40 4 4 0
RPS16 RPS16 P62249 40S ribosomal protein S16 chr19 Not Cancer Driver No 1 intact, hippie 16 14 1 1 0
RPS6 RPS6 P62753 40S ribosomal protein S6 chr9 Not Cancer Driver No 1 hippie 38 150 25 25 0
RPS6KB1 RPS6KB1 P23443 Ribosomal protein S6 kinase beta-1 chr17 Not Cancer Driver No 1 hippie 45 226 26 26 0
RPS6KB2 RPS6KB2 Q9UBS0 Ribosomal protein S6 kinase beta-2 chr11 Not Cancer Driver No 1 hippie 54 194 16 16 0
RPS9_ENST00000391752 RPS9 P46781 40S ribosomal protein S9 chr19 Not Cancer Driver No 1 intact, hippie 23 34 5 5 0
RPTOR RPTOR Q8N122 Regulatory-associated protein of mTOR chr17 Not Cancer Driver No 2 hippie, biogrid 176 241 21 21 0
RRAGB RRAGB Q5VZM2 Ras-related GTP-binding protein B chrX Not Cancer Driver No 1 hippie 67 37 5 5 0
RRAGC RRAGC Q9HB90 Ras-related GTP-binding protein C chr1 Compendium Yes 1 hippie 29 61 1 1 0
RRAGD RRAGD Q9NQL2 Ras-related GTP-binding protein D chr6 Not Cancer Driver No 1 hippie 42 83 5 5 0
RUBCN RUBCN Q92622 Run domain Beclin-1-interacting and cysteine-rich domain-containing protein chr3 Not Cancer Driver No 1 hippie 147 403 57 57 0
RUVBL1 RUVBL1 Q9Y265 RuvB-like 1 chr3 Not Cancer Driver No 1 intact, hippie 54 67 7 7 0
RUVBL2 RUVBL2 Q9Y230 RuvB-like 2 chr19 Not Cancer Driver No 1 hippie 62 100 13 13 0
SCN2B SCN2B O60939 Sodium channel subunit beta-2 chr11 Not Cancer Driver No 3 intact, hippie, biogrid 46 52 7 7 2
SCN3B_ENST00000299333 SCN3B Q9NY72 Sodium channel subunit beta-3 chr11 Not Cancer Driver No 2 intact, hippie, biogrid 63 16 5 5 3
SEMA4C SEMA4C Q9C0C4 Semaphorin-4C chr2 Not Cancer Driver No 1 hippie, biogrid 111 149 27 27 0
SEPT2_ENST00000360051 SEPTIN2 Q15019 Septin-2 chr2 Not Cancer Driver No 1 intact 49 101 11 11 0
SGK1_ENST00000237305 SGK1 O00141 Serine/threonine-protein kinase Sgk1 chr6 Census, Compendium Yes 2 intact, hippie 58 86 16 16 0
SGTB SGTB Q96EQ0 Small glutamine-rich tetratricopeptide repeat-containing protein beta chr5 Not Cancer Driver No 1 hippie 28 114 10 10 0
SHMT2 SHMT2 P34897 Serine hydroxymethyltransferase, mitochondrial chr12 Not Cancer Driver No 1 hippie 57 58 5 5 1
SHOC2 SHOC2 Q9UQ13 Leucine-rich repeat protein SHOC-2 chr10 Not Cancer Driver No 1 hippie 55 110 12 12 2
SIRT1 SIRT1 Q96EB6 NAD-dependent protein deacetylase sirtuin-1 chr10 Not Cancer Driver No 1 hippie 70 435 31 31 0
SIRT7 SIRT7 Q9NRC8 NAD-dependent protein deacetylase sirtuin-7 chr17 Not Cancer Driver No 1 hippie 48 163 15 15 0
SKP2 SKP2 Q13309 S-phase kinase-associated protein 2 chr5 Not Cancer Driver No 1 hippie 52 52 6 6 0
SLC31A1 SLC31A1 O15431 High affinity copper uptake protein 1 chr9 Not Cancer Driver No 1 hippie, biogrid 22 28 6 6 0
SMAD4_ENST00000398417 SMAD4 Q13485 Mothers against decapentaplegic homolog 4 chr18 Census, Compendium Yes 1 hippie 198 195 17 17 8
SMDT1 SMDT1 Q9H4I9 Essential MCU regulator, mitochondrial chr22 Not Cancer Driver No 2 intact, hippie 6 6 0 0 0
SNAPC1 SNAPC1 Q16533 snRNA-activating protein complex subunit 1 chr14 Not Cancer Driver No 1 biogrid 36 158 16 16 0
SOSTDC1 SOSTDC1 Q6X4U4 Sclerostin domain-containing protein 1 chr7 Not Cancer Driver No 1 hippie 22 72 3 3 0
SPN_ENST00000395389 SPN P16150 Leukosialin chr16 Not Cancer Driver No 1 hippie, biogrid 46 357 35 35 0
SQSTM1 SQSTM1 Q13501 Sequestosome-1 chr5 Not Cancer Driver No 1 hippie 54 267 32 32 30
SSB SSB P05455 Lupus La protein chr2 Not Cancer Driver No 1 biogrid 39 181 18 18 0
STAT1 STAT1 P42224 Signal transducer and activator of transcription 1-alpha/beta chr2 Not Cancer Driver No 2 intact, hippie 131 144 25 25 26
STAT3 STAT3 P40763 Signal transducer and activator of transcription 3 chr17 Census, Compendium Yes 1 hippie 110 152 15 15 19
STAU1 STAU1 O95793 Double-stranded RNA-binding protein Staufen homolog 1 chr20 Not Cancer Driver No 1 hippie 77 456 63 63 0
STK38 STK38 Q15208 Serine/threonine-protein kinase 38 chr6 Not Cancer Driver No 1 hippie 57 77 6 6 0
SUMO1_ENST00000392245 SUMO1 P63165 Small ubiquitin-related modifier 1 chr2 Not Cancer Driver No 1 hippie 10 76 7 7 0
SUZ12 SUZ12 Q15022 Polycomb protein SUZ12 chr17 Census, Compendium Yes 1 hippie 83 483 46 46 3
SYNCRIP SYNCRIP O60506 Heterogeneous nuclear ribonucleoprotein Q chr6 Not Cancer Driver No 1 hippie 93 285 39 39 0
TACSTD2 TACSTD2 P09758 Tumor-associated calcium signal transducer 2 chr1 Not Cancer Driver No 1 hippie, biogrid 22 27 1 1 0
TBK1 TBK1 Q9UHD2 Serine/threonine-protein kinase TBK1 chr12 Not Cancer Driver No 1 hippie 101 42 5 5 12
TELO2 TELO2 Q9Y4R8 Telomere length regulation protein TEL2 homolog chr16 Not Cancer Driver No 3 intact, hippie, biogrid 113 154 23 23 5
TERF1 TERF1 P54274 Telomeric repeat-binding factor 1 chr8 Not Cancer Driver No 1 hippie 63 220 34 34 0
TERT TERT O14746 Telomerase reverse transcriptase chr5 Census Yes 1 hippie 110 212 16 16 31
THADA_ENST00000405975 THADA Q6YHU6 Thyroid adenoma-associated protein chr2 Not Cancer Driver No 2 intact, hippie 204 63 6 6 0
TM9SF4 TM9SF4 Q92544 Transmembrane 9 superfamily member 4 chr20 Not Cancer Driver No 1 intact, hippie 76 39 4 4 0
TMEM206_ENST00000261455 PACC1 Q9H813 Proton-activated chloride channel chr1 Not Cancer Driver No 1 intact 51 32 5 5 0
TNFAIP3 TNFAIP3 P21580 Tumor necrosis factor alpha-induced protein 3 chr6 Census, Compendium Yes 1 hippie 98 231 33 33 1
TNFSF13B TNFSF13B Q9Y275 Tumor necrosis factor ligand superfamily member 13B chr13 Not Cancer Driver No 1 hippie 41 91 15 15 0
TNFSF8 TNFSF8 P32971 Tumor necrosis factor ligand superfamily member 8 chr9 Not Cancer Driver No 1 hippie, biogrid 34 30 2 2 0
TP53_ENST00000445888 TP53 P04637 Cellular tumor antigen p53 chr17 Census, Compendium Yes 1 intact, hippie 2891 282 1466 1466 83
TPCN1_ENST00000335509 TPCN1 Q9ULQ1 Two pore channel protein 1 chr12 Not Cancer Driver No 1 intact, hippie 114 99 18 18 0
TPCN2 TPCN2 Q8NHX9 Two pore channel protein 2 chr11 Not Cancer Driver No 1 intact, hippie 73 16 0 0 0
TRAF2 TRAF2 Q12933 TNF receptor-associated factor 2 chr9 Not Cancer Driver No 2 intact, hippie 63 4 1 1 0
TRAF6_ENST00000348124 TRAF6 Q9Y4K3 TNF receptor-associated factor 6 chr11 Not Cancer Driver No 1 hippie 67 62 7 7 0
TRIM25 TRIM25 Q14258 E3 ubiquitin/ISG15 ligase TRIM25 chr17 Not Cancer Driver No 1 hippie 59 225 20 20 0
TRIM28 TRIM28 Q13263 Transcription intermediary factor 1-beta chr19 Not Cancer Driver No 1 hippie 87 430 41 41 0
TRIM37 TRIM37 O94972 E3 ubiquitin-protein ligase TRIM37 chr17 Not Cancer Driver No 1 hippie 119 492 60 60 3
TRMT61A TRMT61A Q96FX7 tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A chr14 Not Cancer Driver No 1 hippie, biogrid 16 74 9 9 0
TTI1 TTI1 O43156 TELO2-interacting protein 1 homolog chr20 Not Cancer Driver No 2 intact, hippie, biogrid 136 93 13 13 0
TUBA1B TUBA1B P68363 Tubulin alpha-1B chain chr12 Not Cancer Driver No 1 biogrid 41 52 9 9 0
TUBB TUBB P07437 Tubulin beta chain chr6 Not Cancer Driver No 1 biogrid 40 63 11 11 5
TUBB4A TUBB4A P04350 Tubulin beta-4A chain chr19 Not Cancer Driver No 1 biogrid 91 61 16 16 2
UBAP2L UBAP2L Q14157 Ubiquitin-associated protein 2-like chr1 Not Cancer Driver No 1 hippie, biogrid 129 1039 128 128 0
UBC UBC P0CG48 Polyubiquitin-C chr12 Not Cancer Driver No 1 biogrid 97 312 53 53 0
UBQLN1 UBQLN1 Q9UMX0 Ubiquilin-1 chr9 Not Cancer Driver No 1 hippie 64 543 58 58 0
UBR5 UBR5 O95071 E3 ubiquitin-protein ligase UBR5 chr8 Census, Compendium Yes 1 hippie 340 1296 162 162 0
ULK1 ULK1 O75385 Serine/threonine-protein kinase ULK1 chr12 Not Cancer Driver No 3 intact, hippie 142 588 77 77 0
UNC93B1 UNC93B1 Q9H1C4 Protein unc-93 homolog B1 chr11 Not Cancer Driver No 1 intact, hippie 57 127 5 5 0
USP7 USP7 Q93009 Ubiquitin carboxyl-terminal hydrolase 7 chr16 Not Cancer Driver No 1 intact 170 215 45 45 0
USP9X_ENST00000378308 USP9X Q93008 Probable ubiquitin carboxyl-terminal hydrolase FAF-X chrX Census, Compendium Yes 1 hippie 339 405 51 51 1
UVRAG UVRAG Q9P2Y5 UV radiation resistance-associated gene protein chr11 Not Cancer Driver No 1 hippie 89 243 28 28 0
VCP VCP P55072 Transitional endoplasmic reticulum ATPase chr9 Not Cancer Driver No 1 hippie 88 186 16 16 16
VHL VHL P40337 von Hippel-Lindau disease tumor suppressor chr3 Census, Compendium Yes 1 hippie 142 117 36 36 133
VIPR2 VIPR2 P41587 Vasoactive intestinal polypeptide receptor 2 chr7 Not Cancer Driver No 2 intact, hippie, biogrid 74 0 0 0 0
VIRMA VIRMA Q69YN4 Protein virilizer homolog chr8 Not Cancer Driver No 1 hippie 211 631 93 93 0
VPS16 VPS16 Q9H269 Vacuolar protein sorting-associated protein 16 homolog chr20 Not Cancer Driver No 1 intact, hippie 104 34 5 5 1
VSIG2 VSIG2 Q96IQ7 V-set and immunoglobulin domain-containing protein 2 chr11 Not Cancer Driver No 3 hippie, biogrid 56 114 14 14 0
VSIG4 VSIG4 Q9Y279 V-set and immunoglobulin domain-containing protein 4 chrX Not Cancer Driver No 1 hippie, biogrid 73 70 13 13 0
WIPI2 WIPI2 Q9Y4P8 WD repeat domain phosphoinositide-interacting protein 2 chr7 Not Cancer Driver No 1 hippie 64 68 5 5 1
WWOX WWOX Q9NZC7 WW domain-containing oxidoreductase chr16 Not Cancer Driver No 1 hippie 79 108 9 9 3
XPO1_ENST00000406957 XPO1 O14980 Exportin-1 chr2 Census, Compendium Yes 1 hippie 140 33 9 9 0
XPO4 XPO4 Q9C0E2 Exportin-4 chr13 Not Cancer Driver No 2 intact, hippie 124 66 5 5 0
XPO6 XPO6 Q96QU8 Exportin-6 chr16 Not Cancer Driver No 1 hippie 133 29 1 1 0
YEATS4 YEATS4 O95619 YEATS domain-containing protein 4 chr12 Not Cancer Driver No 1 intact, hippie 23 17 1 1 0
YWHAQ YWHAQ P27348 14-3-3 protein theta chr2 Not Cancer Driver No 1 hippie 29 41 6 6 0
YWHAZ_ENST00000395956 YWHAZ P63104 14-3-3 protein zeta/delta chr8 Not Cancer Driver No 1 intact, hippie 30 81 10 10 0
ZDHHC18 ZDHHC18 Q9NUE0 Palmitoyltransferase ZDHHC18 chr1 Not Cancer Driver No 1 hippie 30 105 8 8 0
ZDHHC23 ZDHHC23 Q8IYP9 Palmitoyltransferase ZDHHC23 chr3 Not Cancer Driver No 1 hippie 55 49 11 11 0
ZNRF2 ZNRF2 Q8NHG8 E3 ubiquitin-protein ligase ZNRF2 chr7 Not Cancer Driver No 1 hippie 12 147 0 0 0
ZSCAN26 ZSCAN26 Q16670 Zinc finger and SCAN domain-containing protein 26 chr6 Not Cancer Driver No 1 intact, hippie 17 189 6 6 0
ZUP1 ZUP1 Q96AP4 Zinc finger-containing ubiquitin peptidase 1 chr6 Not Cancer Driver No 1 hippie 63 204 19 19 0