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KPNA6 ,KPNA6 ,O60684
  • Uniprot Accession= O60684
  • Ensembl Transcript= ENST00000373625.7
  • Uniprot Name= KPNA6
  • Name= Importin subunit alpha-7
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 42
  • Number of Interaction partner in biogrid: 38
  • Number of Interaction partner in hippie: 132
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ACTC1 ACTC1 P68032 Actin, alpha cardiac muscle 1 chr15 Not Cancer Driver No 1 hippie 114 48 19 19 11
ANKRD11_ENST00000642600 ANKRD11 Q6UB99 Ankyrin repeat domain-containing protein 11 chr16 Not Cancer Driver No 1 intact, hippie 362 2289 299 299 0
ANP32A ANP32A P39687 Acidic leucine-rich nuclear phosphoprotein 32 family member A chr15 Not Cancer Driver No 1 intact, hippie 31 165 21 21 0
ANP32B ANP32B Q92688 Acidic leucine-rich nuclear phosphoprotein 32 family member B chr9 Not Cancer Driver No 1 hippie 22 117 12 12 0
ANP32E ANP32E Q9BTT0 Acidic leucine-rich nuclear phosphoprotein 32 family member E chr1 Not Cancer Driver No 1 hippie, biogrid 40 135 18 18 0
ARMC8_ENST00000469044 ARMC8 Q8IUR7 Armadillo repeat-containing protein 8 chr3 Not Cancer Driver No 1 hippie 71 7 0 0 0
ARNT ARNT P27540 Aryl hydrocarbon receptor nuclear translocator chr1 Census Yes 1 hippie 77 511 56 56 0
BCOR BCOR Q6W2J9 BCL-6 corepressor chrX Census, Compendium Yes 1 hippie 291 1285 226 226 1
BIRC3_ENST00000532808 BIRC3 Q13489 Baculoviral IAP repeat-containing protein 3 chr11 Census, Compendium Yes 1 hippie 77 98 16 16 0
BRCA1_ENST00000357654 BRCA1 P38398 Breast cancer type 1 susceptibility protein chr17 Census, Compendium Yes 1 hippie 224 1458 174 174 35
C18orf25 C18orf25 Q96B23 Uncharacterized protein C18orf25 chr18 Not Cancer Driver No 1 hippie, biogrid 30 393 27 27 0
CBX1_ENST00000225603 CBX1 P83916 Chromobox protein homolog 1 chr17 Not Cancer Driver No 1 intact, hippie 31 154 25 25 0
CBX3_ENST00000396386 CBX3 Q13185 Chromobox protein homolog 3 chr7 Not Cancer Driver No 1 intact, hippie 23 119 18 18 0
CCNF CCNF P41002 Cyclin-F chr16 Not Cancer Driver No 1 hippie, biogrid 106 221 23 23 3
CD2BP2 CD2BP2 O95400 CD2 antigen cytoplasmic tail-binding protein 2 chr16 Not Cancer Driver No 1 hippie, biogrid 49 259 40 40 0
CDC34 CDC34 P49427 Ubiquitin-conjugating enzyme E2 R1 chr19 Not Cancer Driver No 1 hippie 26 95 11 11 0
CDK2AP1 CDK2AP1 O14519 Cyclin-dependent kinase 2-associated protein 1 chr12 Not Cancer Driver No 1 hippie 10 76 8 8 0
CDKN1B CDKN1B P46527 Cyclin-dependent kinase inhibitor 1B chr12 Census, Compendium Yes 1 hippie 19 198 19 19 0
CENPA CENPA P49450 Histone H3-like centromeric protein A chr2 Not Cancer Driver No 1 hippie, biogrid 15 50 4 4 0
CENPU CENPU Q71F23 Centromere protein U chr4 Not Cancer Driver No 1 intact, hippie 51 298 42 42 0
CFTR CFTR P13569 Cystic fibrosis transmembrane conductance regulator chr7 Not Cancer Driver No 1 hippie 287 145 18 18 151
CHD4 CHD4 Q14839 Chromodomain-helicase-DNA-binding protein 4 chr12 Census, Compendium Yes 1 hippie 419 974 177 177 6
CHD8_ENST00000643469 CHD8 Q9HCK8 Chromodomain-helicase-DNA-binding protein 8 chr14 Not Cancer Driver No 1 hippie 328 1411 148 148 0
CHMP4B CHMP4B Q9H444 Charged multivesicular body protein 4b chr20 Not Cancer Driver No 1 hippie 25 201 22 22 2
CLK3 CLK3 P49761 Dual specificity protein kinase CLK3 chr15 Not Cancer Driver No 1 hippie, biogrid 67 295 27 27 0
COPS5 COPS5 Q92905 COP9 signalosome complex subunit 5 chr8 Not Cancer Driver No 1 hippie 36 32 7 7 0
CREBBP CREBBP Q92793 CREB-binding protein chr16 Census, Compendium Yes 1 hippie 412 1796 247 247 33
CSE1L CSE1L P55060 Exportin-2 chr20 Not Cancer Driver No 1 hippie 109 32 5 5 0
CUL3 CUL3 Q13618 Cullin-3 chr2 Census, Compendium Yes 1 intact, hippie 123 167 23 23 3
DCPS DCPS Q96C86 m7GpppX diphosphatase chr11 Not Cancer Driver No 1 intact, hippie 48 53 6 6 1
EFTUD2 EFTUD2 Q15029 116 kDa U5 small nuclear ribonucleoprotein component chr17 Compendium Yes 1 hippie 132 179 30 30 3
ELAVL1 ELAVL1 Q15717 ELAV-like protein 1 chr19 Not Cancer Driver No 1 hippie 69 43 5 5 0
EPAS1 EPAS1 Q99814 Endothelial PAS domain-containing protein 1 chr2 Census, Compendium Yes 1 hippie 120 449 53 53 6
EXOSC4 EXOSC4 Q9NPD3 Exosome complex component RRP41 chr8 Not Cancer Driver No 1 hippie, biogrid 34 23 0 0 0
FAM90A1 FAM90A1 Q86YD7 Protein FAM90A1 chr12 Not Cancer Driver No 1 intact, hippie 123 461 121 121 0
FBL FBL P22087 rRNA 2'-O-methyltransferase fibrillarin chr19 Not Cancer Driver No 1 hippie, biogrid 46 145 22 22 0
FOXE1 FOXE1 O00358 Forkhead box protein E1 chr9 Not Cancer Driver No 1 hippie 38 133 5 5 4
G3BP1 G3BP1 Q13283 Ras GTPase-activating protein-binding protein 1 chr5 Not Cancer Driver No 2 intact, hippie 85 352 65 65 0
GABARAPL2 GABARAPL2 P60520 Gamma-aminobutyric acid receptor-associated protein-like 2 chr16 Not Cancer Driver No 1 hippie 11 2 1 1 0
GEMIN2 GEMIN2 O14893 Gem-associated protein 2 chr14 Not Cancer Driver No 1 intact, hippie 39 99 6 6 0
GFPT1 GFPT1 Q06210 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 chr2 Not Cancer Driver No 1 hippie 81 75 8 8 13
HASPIN HASPIN Q8TF76 Serine/threonine-protein kinase haspin chr17 Not Cancer Driver No 1 intact, hippie 87 373 36 36 0
HDAC1 HDAC1 Q13547 Histone deacetylase 1 chr1 Not Cancer Driver No 2 intact, hippie, biogrid 47 135 10 10 0
HIF1A_ENST00000337138 HIF1A Q16665 Hypoxia-inducible factor 1-alpha chr14 Census Yes 1 hippie 118 435 51 51 0
HMGB1_ENST00000405805 HMGB1 P09429 High mobility group protein B1 chr13 Not Cancer Driver No 1 hippie, biogrid 25 203 20 20 0
IKBKG_ENST00000611071 IKBKG Q9Y6K9 NF-kappa-B essential modulator chrX Not Cancer Driver No 1 hippie 6 301 6 6 22
IL1A IL1A P01583 Interleukin-1 alpha chr2 Not Cancer Driver No 1 intact, hippie 30 35 6 6 0
IPO5_ENST00000490680 IPO5 O00410 Importin-5 chr13 Not Cancer Driver No 1 hippie, biogrid 128 52 3 3 0
IRF3_ENST00000597198 IRF3 Q14653 Interferon regulatory factor 3 chr19 Not Cancer Driver No 1 intact, hippie 36 204 21 21 1
JRK_ENST00000571961 JRK O75564 Jerky protein homolog chr8 Not Cancer Driver No 1 intact, hippie 56 140 17 17 0
KAT5_ENST00000377046 KAT5 Q92993 Histone acetyltransferase KAT5 chr11 Not Cancer Driver No 1 intact, hippie 65 173 21 21 3
KBTBD4_ENST00000395288 KBTBD4 Q9NVX7 Kelch repeat and BTB domain-containing protein 4 chr11 Not Cancer Driver No 2 hippie, biogrid 79 8 3 3 0
KEAP1_ENST00000393623 KEAP1 Q14145 Kelch-like ECH-associated protein 1 chr19 Census, Compendium Yes 1 hippie 237 57 12 12 0
KPNA1 KPNA1 P52294 Importin subunit alpha-5 chr3 Not Cancer Driver No 2 hippie, biogrid 65 121 18 18 0
KPNA2_ENST00000330459 KPNA2 P52292 Importin subunit alpha-1 chr17 Not Cancer Driver No 2 hippie, biogrid 74 129 18 18 0
KPNA3 KPNA3 O00505 Importin subunit alpha-4 chr13 Not Cancer Driver No 1 hippie 65 108 11 11 0
KPNB1 KPNB1 Q14974 Importin subunit beta-1 chr17 Not Cancer Driver No 2 hippie, biogrid 92 94 11 11 0
KSR1_ENST00000644974 KSR1 Q8IVT5 Kinase suppressor of Ras 1 chr17 Not Cancer Driver No 1 intact, hippie 114 404 58 58 0
LARP7_ENST00000344442 LARP7 Q4G0J3 La-related protein 7 chr4 Not Cancer Driver No 2 intact, hippie 58 350 44 44 0
LMBR1L LMBR1L Q6UX01 Protein LMBR1L chr12 Not Cancer Driver No 1 hippie 57 4 0 0 0
LMNA LMNA P02545 Prelamin-A/C chr1 Census Yes 3 intact, hippie, biogrid 68 544 49 49 131
LMNB1 LMNB1 P20700 Lamin-B1 chr5 Not Cancer Driver No 1 intact, hippie 60 404 42 42 4
LYAR_ENST00000452476 LYAR Q9NX58 Cell growth-regulating nucleolar protein chr4 Not Cancer Driver No 2 intact, hippie, biogrid 50 249 31 31 0
MAGED1_ENST00000326587 MAGED1 Q9Y5V3 Melanoma-associated antigen D1 chrX Not Cancer Driver No 1 hippie 131 457 71 71 0
MAP1LC3B MAP1LC3B Q9GZQ8 Microtubule-associated proteins 1A/1B light chain 3B chr16 Not Cancer Driver No 1 hippie 10 17 1 1 0
MCM2 MCM2 P49736 DNA replication licensing factor MCM2 chr3 Not Cancer Driver No 1 hippie 104 275 38 38 1
MDM2_ENST00000539479 MDM2 Q00987 E3 ubiquitin-protein ligase Mdm2 chr12 Census, Compendium Yes 1 hippie 56 297 37 37 0
MEAF6_ENST00000296214 MEAF6 Q9HAF1 Chromatin modification-related protein MEAF6 chr1 Not Cancer Driver No 1 intact, hippie, biogrid 22 171 21 21 0
MEPCE MEPCE Q7L2J0 7SK snRNA methylphosphate capping enzyme chr7 Not Cancer Driver No 1 hippie, biogrid 76 446 42 42 0
METTL16 METTL16 Q86W50 RNA N6-adenosine-methyltransferase METTL16 chr17 Not Cancer Driver No 1 hippie 55 172 22 22 0
MORF4L1 MORF4L1 Q9UBU8 Mortality factor 4-like protein 1 chr15 Not Cancer Driver No 1 hippie, biogrid 43 163 17 17 0
MORF4L2_ENST00000433176 MORF4L2 Q15014 Mortality factor 4-like protein 2 chrX Not Cancer Driver No 1 hippie, biogrid 44 136 21 21 0
MTHFR_ENST00000376590 MTHFR P42898 Methylenetetrahydrofolate reductase chr1 Not Cancer Driver No 1 hippie, biogrid 95 125 22 22 53
NAF1 NAF1 Q96HR8 H/ACA ribonucleoprotein complex non-core subunit NAF1 chr4 Not Cancer Driver No 1 intact, hippie 61 386 44 44 0
NCBP1 NCBP1 Q09161 Nuclear cap-binding protein subunit 1 chr9 Not Cancer Driver No 1 intact 88 89 8 8 0
NCBP2_ENST00000427641 NCBP2 P52298-3 Isoform 3 of Nuclear cap-binding protein subunit 2 chr3 Not Cancer Driver No 1 hippie 21 61 9 9 0
NCBP3 NCBP3 Q53F19 Nuclear cap-binding protein subunit 3 chr17 Not Cancer Driver No 1 hippie 52 507 42 42 0
NLRC5_ENST00000436936 NLRC5 Q86WI3 Protein NLRC5 chr16 Not Cancer Driver No 1 intact, hippie 262 114 19 19 0
NMNAT1 NMNAT1 Q9HAN9 Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 chr1 Not Cancer Driver No 1 intact, hippie 39 49 7 7 28
NOP2_ENST00000322166 NOP2 P46087 Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase chr12 Not Cancer Driver No 1 intact, hippie 116 510 72 72 0
NOP56 NOP56 O00567 Nucleolar protein 56 chr20 Not Cancer Driver No 2 hippie, biogrid 83 191 34 34 0
NOP58 NOP58 Q9Y2X3 Nucleolar protein 58 chr2 Not Cancer Driver No 1 hippie, biogrid 47 156 14 14 0
NR2C2_ENST00000393102 NR2C2 P49116 Nuclear receptor subfamily 2 group C member 2 chr3 Not Cancer Driver No 1 hippie 62 186 24 24 0
NR4A1_ENST00000394825 NR4A1 P22736 Nuclear receptor subfamily 4 group A member 1 chr12 Not Cancer Driver No 1 hippie 62 252 24 24 0
NTRK1 NTRK1 P04629 High affinity nerve growth factor receptor chr1 Census, Compendium Yes 1 hippie 168 57 8 8 25
NUP153_ENST00000262077 NUP153 P49790 Nuclear pore complex protein Nup153 chr6 Not Cancer Driver No 1 hippie 180 1152 147 147 0
NUP50 NUP50 Q9UKX7 Nuclear pore complex protein Nup50 chr22 Not Cancer Driver No 5 intact, hippie, biogrid 58 333 40 40 0
NUPR1_ENST00000324873 NUPR1 O60356 Nuclear protein 1 chr16 Not Cancer Driver No 1 hippie 10 82 10 10 0
OGT OGT O15294 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit chrX Not Cancer Driver No 1 hippie 156 89 16 16 2
PHB2 PHB2 Q99623 Prohibitin-2 chr12 Not Cancer Driver No 1 hippie 31 26 4 4 0
PLEKHA4 PLEKHA4 Q9H4M7 Pleckstrin homology domain-containing family A member 4 chr19 Not Cancer Driver No 1 hippie 136 687 128 128 0
POLR3C POLR3C Q9BUI4 DNA-directed RNA polymerase III subunit RPC3 chr1 Not Cancer Driver No 1 intact, hippie 60 161 21 21 0
POM121_ENST00000434423 POM121 Q96HA1 Nuclear envelope pore membrane protein POM 121 chr7 Not Cancer Driver No 1 intact, hippie 160 1072 130 130 0
POU6F2 POU6F2 P78424 POU domain, class 6, transcription factor 2 chr7 Not Cancer Driver No 1 intact, hippie 165 571 144 144 1
PPM1D PPM1D O15297 Protein phosphatase 1D chr17 Census, Compendium Yes 1 hippie 54 370 32 32 0
PPM1G PPM1G O15355 Protein phosphatase 1G chr2 Not Cancer Driver No 1 hippie, biogrid 51 359 39 39 0
PPP1CC_ENST00000335007 PPP1CC P36873 Serine/threonine-protein phosphatase PP1-gamma catalytic subunit chr12 Not Cancer Driver No 1 hippie 26 23 4 4 0
PRKAR2A PRKAR2A P13861 cAMP-dependent protein kinase type II-alpha regulatory subunit chr3 Not Cancer Driver No 1 hippie 37 149 13 13 0
PRMT1 PRMT1 Q99873 Protein arginine N-methyltransferase 1 chr19 Not Cancer Driver No 1 hippie, biogrid 50 18 1 1 0
PSMC2_ENST00000292644 PSMC2 P35998 26S proteasome regulatory subunit 7 chr7 Not Cancer Driver No 1 hippie, biogrid 63 120 13 13 0
PTPN2 PTPN2 P17706 Tyrosine-protein phosphatase non-receptor type 2 chr18 Not Cancer Driver No 1 intact, hippie 57 120 14 14 0
RAC1_ENST00000348035 RAC1 P63000 Ras-related C3 botulinum toxin substrate 1 chr7 Census, Compendium Yes 1 intact, hippie 66 2 1 1 6
RANBP6 RANBP6 O60518 Ran-binding protein 6 chr9 Not Cancer Driver No 1 hippie, biogrid 152 46 4 4 0
RAN_ENST00000392369 RAN P62826 GTP-binding nuclear protein Ran chr12 Not Cancer Driver No 1 hippie, biogrid 20 14 1 1 0
RBBP4 RBBP4 Q09028 Histone-binding protein RBBP4 chr1 Not Cancer Driver No 1 hippie 53 169 23 23 0
RBBP7_ENST00000380087 RBBP7 Q16576 Histone-binding protein RBBP7 chrX Not Cancer Driver No 1 intact, hippie 67 138 19 19 0
RECQL4 RECQL4 O94761 ATP-dependent DNA helicase Q4 chr8 Census, Compendium Yes 1 hippie 138 608 71 71 1
RELA RELA Q04206 Transcription factor p65 chr11 Compendium Yes 1 hippie 75 400 48 48 0
RELB RELB Q01201 Transcription factor RelB chr19 Not Cancer Driver No 1 intact, hippie 65 348 39 39 0
RNMT_ENST00000543302 RNMT O43148 mRNA cap guanine-N7 methyltransferase chr18 Not Cancer Driver No 2 intact, hippie, biogrid 67 159 23 23 0
RPL11 RPL11 P62913 60S ribosomal protein L11 chr1 Not Cancer Driver No 1 hippie, biogrid 27 12 1 1 1
SF1_ENST00000377390 SF1 Q15637 Splicing factor 1 chr11 Not Cancer Driver No 1 hippie 110 627 106 106 0
SIRT1 SIRT1 Q96EB6 NAD-dependent protein deacetylase sirtuin-1 chr10 Not Cancer Driver No 1 hippie, biogrid 70 435 31 31 0
SIRT6 SIRT6 Q8N6T7 NAD-dependent protein deacylase sirtuin-6 chr19 Not Cancer Driver No 1 hippie 33 164 12 12 0
SKP2 SKP2 Q13309 S-phase kinase-associated protein 2 chr5 Not Cancer Driver No 1 hippie 52 52 6 6 0
SMARCB1_ENST00000644036 SMARCB1 Q12824 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 chr22 Census, Compendium Yes 1 intact, hippie 64 141 35 35 3
SP110_ENST00000358662 SP110 Q9HB58 Sp110 nuclear body protein chr2 Not Cancer Driver No 1 hippie, biogrid 92 368 54 54 0
SPOP SPOP O43791 Speckle-type POZ protein chr17 Census, Compendium Yes 1 hippie, biogrid 147 25 5 5 6
SREK1IP1 SREK1IP1 Q8N9Q2 Protein SREK1IP1 chr5 Not Cancer Driver No 2 intact, hippie, biogrid 20 132 18 18 0
STAT1 STAT1 P42224 Signal transducer and activator of transcription 1-alpha/beta chr2 Not Cancer Driver No 2 intact, hippie 131 144 25 25 26
STAT3 STAT3 P40763 Signal transducer and activator of transcription 3 chr17 Census, Compendium Yes 1 hippie 110 152 15 15 19
SURF2 SURF2 Q15527 Surfeit locus protein 2 chr9 Not Cancer Driver No 2 intact, hippie, biogrid 27 146 20 20 0
TAF9 TAF9 Q16594 Transcription initiation factor TFIID subunit 9 chr5 Not Cancer Driver No 1 hippie 25 203 19 19 0
TRIM28 TRIM28 Q13263 Transcription intermediary factor 1-beta chr19 Not Cancer Driver No 1 hippie 87 430 41 41 0
TRIM33 TRIM33 Q9UPN9 E3 ubiquitin-protein ligase TRIM33 chr1 Census, Compendium Yes 1 hippie 110 617 51 51 0
TRIP12_ENST00000283943 TRIP12 Q14669 E3 ubiquitin-protein ligase TRIP12 chr2 Not Cancer Driver No 1 intact, hippie 224 845 117 117 4
TTC1 TTC1 Q99614 Tetratricopeptide repeat protein 1 chr5 Not Cancer Driver No 1 hippie 28 211 21 21 0
UBE2O UBE2O Q9C0C9 (E3-independent) E2 ubiquitin-conjugating enzyme chr17 Not Cancer Driver No 1 hippie, biogrid 129 716 68 68 0
UNK UNK Q9C0B0 RING finger protein unkempt homolog chr17 Not Cancer Driver No 1 hippie 79 511 46 46 0
VIRMA VIRMA Q69YN4 Protein virilizer homolog chr8 Not Cancer Driver No 1 hippie 211 631 93 93 0
VPS35 VPS35 Q96QK1 Vacuolar protein sorting-associated protein 35 chr16 Not Cancer Driver No 1 hippie 68 99 9 9 1
XRN2 XRN2 Q9H0D6 5'-3' exoribonuclease 2 chr20 Not Cancer Driver No 2 intact, hippie 129 427 63 63 0
ZNF131 ZNF131 P52739 Zinc finger protein 131 chr5 Not Cancer Driver No 1 hippie 79 266 41 41 0