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JAK1 ,JAK1 ,P23458
  • Uniprot Accession= P23458
  • Ensembl Transcript= ENST00000342505.4
  • Uniprot Name= JAK1
  • Name= Tyrosine-protein kinase JAK1
  • Chromosome= chr1
  • Driver status= Census, Compendium
  • Number of Interaction partner in intact: 31
  • Number of Interaction partner in biogrid: 65
  • Number of Interaction partner in hippie: 209
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ABL1_ENST00000318560 ABL1 P00519 Tyrosine-protein kinase ABL1 chr9 Census, Compendium Yes 1 hippie 139 604 73 73 2
ABL2 ABL2 P42684 Tyrosine-protein kinase ABL2 chr1 Census, Compendium Yes 1 hippie 171 641 70 70 0
ADAM11 ADAM11 O75078 Disintegrin and metalloproteinase domain-containing protein 11 chr17 Not Cancer Driver No 1 hippie, biogrid 98 163 17 17 0
AGO4 AGO4 Q9HCK5 Protein argonaute-4 chr1 Not Cancer Driver No 1 intact, hippie 100 183 24 24 0
AGTR1_ENST00000349243 AGTR1 P30556 Type-1 angiotensin II receptor chr3 Not Cancer Driver No 1 intact, hippie 95 0 0 0 1
AMHR2 AMHR2 Q16671 Anti-Muellerian hormone type-2 receptor chr12 Not Cancer Driver No 1 hippie, biogrid 77 117 7 7 8
APLNR APLNR P35414 Apelin receptor chr11 Not Cancer Driver No 2 intact, hippie, biogrid 96 29 8 8 0
ARL15 ARL15 Q9NXU5 ADP-ribosylation factor-like protein 15 chr5 Not Cancer Driver No 1 hippie, biogrid 24 9 2 2 0
ARRB1 ARRB1 P49407 Beta-arrestin-1 chr11 Not Cancer Driver No 1 hippie, biogrid 49 154 13 13 0
ATIC ATIC P31939 Bifunctional purine biosynthesis protein ATIC chr2 Census Yes 1 hippie, biogrid 74 25 1 1 1
BRCA1_ENST00000357654 BRCA1 P38398 Breast cancer type 1 susceptibility protein chr17 Census, Compendium Yes 1 intact, hippie 224 1458 174 174 35
BSND BSND Q8WZ55 Barttin chr1 Not Cancer Driver No 1 hippie, biogrid 57 209 36 36 4
BTK_ENST00000308731 BTK Q06187 Tyrosine-protein kinase BTK chrX Census, Compendium Yes 1 hippie 147 114 27 27 110
BTN2A1 BTN2A1 Q7KYR7 Butyrophilin subfamily 2 member A1 chr6 Not Cancer Driver No 1 hippie, biogrid 86 38 9 9 0
CBL CBL P22681 E3 ubiquitin-protein ligase CBL chr11 Census, Compendium Yes 1 hippie 115 512 56 56 4
CCR1 CCR1 P32246 C-C chemokine receptor type 1 chr3 Not Cancer Driver No 1 hippie 69 14 5 5 0
CCR5 CCR5 P51681 C-C chemokine receptor type 5 chr3 Not Cancer Driver No 1 hippie 107 0 0 0 0
CD83 CD83 Q01151 CD83 antigen chr6 Not Cancer Driver No 1 hippie, biogrid 24 48 8 8 0
CDC42_ENST00000344548 CDC42 P60953 Cell division control protein 42 homolog chr1 Not Cancer Driver No 1 hippie 39 23 2 2 1
CFTR CFTR P13569 Cystic fibrosis transmembrane conductance regulator chr7 Not Cancer Driver No 1 hippie 287 145 18 18 151
CHMP4B CHMP4B Q9H444 Charged multivesicular body protein 4b chr20 Not Cancer Driver No 1 hippie 25 201 22 22 2
CIC CIC Q96RK0 Protein capicua homolog chr19 Census, Compendium Yes 1 hippie 276 1550 266 266 0
CLDND1_ENST00000510545 CLDND1 Q9NY35 Claudin domain-containing protein 1 chr3 Not Cancer Driver No 1 hippie, biogrid 32 0 0 0 0
CLEC4A CLEC4A Q9UMR7 C-type lectin domain family 4 member A chr12 Not Cancer Driver No 1 hippie, biogrid 35 22 4 4 0
CMKLR1 CMKLR1 Q99788 Chemerin-like receptor 1 chr12 Not Cancer Driver No 1 hippie, biogrid 107 24 13 13 0
CRLF2_ENST00000381566 CRLF2 Q9HC73 Cytokine receptor-like factor 2 chrX Census Yes 1 hippie, biogrid 54 62 3 3 0
CSF2RB CSF2RB P32927 Cytokine receptor common subunit beta chr22 Not Cancer Driver No 2 intact, hippie 204 541 120 120 0
CSF3R_ENST00000361632 CSF3R Q99062 Granulocyte colony-stimulating factor receptor chr1 Census, Compendium Yes 1 hippie 131 209 34 34 2
CSNK1G2 CSNK1G2 P78368 Casein kinase I isoform gamma-2 chr19 Not Cancer Driver No 1 hippie, biogrid 43 111 13 13 0
CTDSPL2 CTDSPL2 Q05D32 CTD small phosphatase-like protein 2 chr15 Not Cancer Driver No 1 hippie 47 256 27 27 0
CX3CL1 CX3CL1 P78423 Fractalkine chr16 Not Cancer Driver No 1 hippie, biogrid 66 259 44 44 0
CXCR4_ENST00000241393 CXCR4 P61073 C-X-C chemokine receptor type 4 chr2 Census, Compendium Yes 2 hippie, biogrid 62 5 1 1 0
CYLD CYLD Q9NQC7 Ubiquitin carboxyl-terminal hydrolase CYLD chr16 Census, Compendium Yes 1 hippie 116 213 31 31 3
DISC1_ENST00000439617 DISC1 Q9NRI5 Disrupted in schizophrenia 1 protein chr1 Not Cancer Driver No 1 intact, hippie 132 514 82 82 0
DLK1 DLK1 P80370 Protein delta homolog 1 chr14 Not Cancer Driver No 1 hippie, biogrid 81 0 0 0 0
DSP DSP P15924 Desmoplakin chr6 Not Cancer Driver No 1 intact, hippie 483 1124 204 204 6
DTX3L DTX3L Q8TDB6 E3 ubiquitin-protein ligase DTX3L chr3 Not Cancer Driver No 1 hippie 86 260 24 24 0
EDAR EDAR Q9UNE0 Tumor necrosis factor receptor superfamily member EDAR chr2 Not Cancer Driver No 1 hippie, biogrid 81 116 20 20 18
EFNB1 EFNB1 P98172 Ephrin-B1 chrX Not Cancer Driver No 1 hippie, biogrid 46 126 14 14 19
EGFR EGFR P00533 Epidermal growth factor receptor chr7 Census, Compendium Yes 1 hippie 444 223 35 35 1
EID1 EID1 Q9Y6B2 EP300-interacting inhibitor of differentiation 1 chr15 Not Cancer Driver No 1 hippie 22 159 17 17 0
EIF2AK2_ENST00000395127 EIF2AK2 P19525 Interferon-induced, double-stranded RNA-activated protein kinase chr2 Not Cancer Driver No 1 hippie 59 188 22 22 0
EIF4A3 EIF4A3 P38919 Eukaryotic initiation factor 4A-III chr17 Not Cancer Driver No 1 hippie 50 57 6 6 1
ELF3_ENST00000367283 ELF3 P78545 ETS-related transcription factor Elf-3 chr1 Census, Compendium Yes 1 hippie, biogrid 94 145 34 34 0
ELOVL5_ENST00000304434 ELOVL5 Q9NYP7 Elongation of very long chain fatty acids protein 5 chr6 Not Cancer Driver No 1 hippie, biogrid 34 25 4 4 2
ELP2_ENST00000358232 ELP2 Q6IA86 Elongator complex protein 2 chr18 Not Cancer Driver No 1 hippie 65 16 2 2 0
EMC4 EMC4 Q5J8M3 ER membrane protein complex subunit 4 chr15 Not Cancer Driver No 1 hippie 15 17 2 2 0
ERBB2 ERBB2 P04626 Receptor tyrosine-protein kinase erbB-2 chr17 Census, Compendium Yes 1 hippie 275 314 41 41 1
ESR1_ENST00000206249 ESR1 P03372 Estrogen receptor chr6 Census, Compendium Yes 1 hippie 121 195 27 27 2
FAM174A FAM174A Q8TBP5 Membrane protein FAM174A chr5 Not Cancer Driver No 1 hippie, biogrid 27 140 21 21 0
FBXW7_ENST00000603841 FBXW7 Q969H0 F-box/WD repeat-containing protein 7 chr4 Census, Compendium Yes 1 hippie 322 230 38 38 0
FER FER P16591 Tyrosine-protein kinase Fer chr5 Not Cancer Driver No 1 hippie 114 145 21 21 0
FES FES P07332 Tyrosine-protein kinase Fes/Fps chr15 Census Yes 1 hippie 103 245 34 34 0
FFAR1 FFAR1 O14842 Free fatty acid receptor 1 chr19 Not Cancer Driver No 1 hippie, biogrid 45 2 0 0 0
FLG2 FLG2 Q5D862 Filaggrin-2 chr1 Not Cancer Driver No 1 intact, hippie 613 2252 577 577 0
FYN FYN P06241 Tyrosine-protein kinase Fyn chr6 Not Cancer Driver No 1 hippie 92 70 13 13 0
GAB1_ENST00000262994 GAB1 Q13480 GRB2-associated-binding protein 1 chr4 Not Cancer Driver No 1 hippie 79 570 68 68 1
GHR_ENST00000612382 GHR P10912 Growth hormone receptor chr5 Not Cancer Driver No 1 hippie 173 229 66 66 19
GPR182 GPR182 O15218 G-protein coupled receptor 182 chr12 Not Cancer Driver No 1 hippie, biogrid 49 33 4 4 0
GPR45 GPR45 Q9Y5Y3 Probable G-protein coupled receptor 45 chr2 Not Cancer Driver No 1 hippie, biogrid 97 0 0 0 0
GPRC5B_ENST00000569479 GPRC5B Q9NZH0 G-protein coupled receptor family C group 5 member B chr16 Not Cancer Driver No 1 hippie, biogrid 82 75 19 19 0
GRB2_ENST00000392564 GRB2 P62993 Growth factor receptor-bound protein 2 chr17 Not Cancer Driver No 1 hippie 28 10 1 1 0
HAVCR2 HAVCR2 Q8TDQ0 Hepatitis A virus cellular receptor 2 chr5 Not Cancer Driver No 2 intact, hippie, biogrid 69 17 2 2 3
HCST HCST Q9UBK5 Hematopoietic cell signal transducer chr19 Not Cancer Driver No 1 hippie, biogrid 6 12 0 0 0
HNRNPD HNRNPD Q14103 Heterogeneous nuclear ribonucleoprotein D0 chr4 Not Cancer Driver No 1 intact, hippie 39 206 19 19 0
HSP90AA1_ENST00000216281 HSP90AA1 P07900 Heat shock protein HSP 90-alpha chr14 Census, Compendium Yes 1 hippie 106 257 37 37 0
HSP90AB1 HSP90AB1 P08238 Heat shock protein HSP 90-beta chr6 Census, Compendium Yes 1 intact, hippie 100 254 43 43 0
HSPB8 HSPB8 Q9UJY1 Heat shock protein beta-8 chr12 Not Cancer Driver No 1 hippie, biogrid 40 130 31 31 5
IFI16_ENST00000295809 IFI16 Q16666 Gamma-interferon-inducible protein 16 chr1 Not Cancer Driver No 1 hippie 155 419 90 90 0
IFITM3 IFITM3 Q01628 Interferon-induced transmembrane protein 3 chr11 Not Cancer Driver No 1 hippie, biogrid 69 18 5 5 0
IFNAR1 IFNAR1 P17181 Interferon alpha/beta receptor 1 chr21 Compendium Yes 2 hippie, biogrid 55 50 6 6 0
IFNAR2 IFNAR2 P48551 Interferon alpha/beta receptor 2 chr21 Not Cancer Driver No 2 intact, hippie 58 199 24 24 0
IFNGR1 IFNGR1 P15260 Interferon gamma receptor 1 chr6 Compendium Yes 3 intact, hippie, biogrid 55 175 22 22 10
IFNLR1 IFNLR1 Q8IU57 Interferon lambda receptor 1 chr1 Not Cancer Driver No 1 hippie, biogrid 57 256 33 33 0
IFT88_ENST00000351808 IFT88 Q13099 Intraflagellar transport protein 88 homolog chr13 Not Cancer Driver No 1 hippie 99 280 30 30 0
IGF1R IGF1R P08069 Insulin-like growth factor 1 receptor chr15 Not Cancer Driver No 1 hippie 183 265 37 37 6
IL10RA IL10RA Q13651 Interleukin-10 receptor subunit alpha chr11 Not Cancer Driver No 1 hippie 77 220 26 26 7
IL13RA2_ENST00000243213 IL13RA2 Q14627 Interleukin-13 receptor subunit alpha-2 chrX Not Cancer Driver No 2 intact, hippie, biogrid 69 0 0 0 0
IL20RB IL20RB Q6UXL0 Interleukin-20 receptor subunit beta chr3 Not Cancer Driver No 1 hippie, biogrid 40 0 0 0 0
IL21R_ENST00000395754 IL21R Q9HBE5 Interleukin-21 receptor chr16 Census Yes 1 hippie 133 183 47 47 1
IL27RA IL27RA Q6UWB1 Interleukin-27 receptor subunit alpha chr19 Not Cancer Driver No 1 hippie 91 167 23 23 0
IL2RB IL2RB P14784 Interleukin-2 receptor subunit beta chr22 Not Cancer Driver No 1 hippie 81 182 33 33 1
IL2RG IL2RG P31785 Cytokine receptor common subunit gamma chrX Not Cancer Driver No 1 hippie 56 32 6 6 33
IL3RA IL3RA P26951 Interleukin-3 receptor subunit alpha chrX Not Cancer Driver No 1 hippie 89 9 2 2 0
IL4R_ENST00000543915 IL4R P24394 Interleukin-4 receptor subunit alpha chr16 Not Cancer Driver No 3 intact, hippie, biogrid 133 420 64 64 0
IL5RA_ENST00000256452 IL5RA Q01344 Interleukin-5 receptor subunit alpha chr3 Not Cancer Driver No 1 intact, hippie 92 23 5 5 0
IL6R IL6R P08887 Interleukin-6 receptor subunit alpha chr1 Not Cancer Driver No 1 intact, hippie 55 165 23 23 1
IL6ST_ENST00000336909 IL6ST P40189 Interleukin-6 receptor subunit beta chr5 Census, Compendium Yes 2 intact, hippie 102 315 40 40 2
IL7R IL7R P16871 Interleukin-7 receptor subunit alpha chr5 Census, Compendium Yes 1 hippie 177 88 48 48 1
IL9R IL9R Q01113 Interleukin-9 receptor chrX Not Cancer Driver No 1 hippie 96 78 18 18 0
INPP5D INPP5D Q92835 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 chr2 Not Cancer Driver No 1 hippie 176 578 90 90 0
INSR INSR P06213 Insulin receptor chr19 Not Cancer Driver No 1 hippie 190 280 57 57 64
INSRR INSRR P14616 Insulin receptor-related protein chr1 Not Cancer Driver No 1 hippie, biogrid 262 228 37 37 0
IRS1 IRS1 P35568 Insulin receptor substrate 1 chr2 Not Cancer Driver No 1 hippie 161 1072 133 133 2
IRS2 IRS2 Q9Y4H2 Insulin receptor substrate 2 chr13 Not Cancer Driver No 1 hippie 69 1112 57 57 0
ISG15 ISG15 P05161 Ubiquitin-like protein ISG15 chr1 Not Cancer Driver No 1 hippie 12 24 2 2 0
JAK1 JAK1 P23458 Tyrosine-protein kinase JAK1 chr1 Census, Compendium Yes 1 hippie 147 120 7 7 2
JAK2 JAK2 O60674 Tyrosine-protein kinase JAK2 chr9 Census, Compendium Yes 1 hippie 136 59 5 5 5
JAK3 JAK3 P52333 Tyrosine-protein kinase JAK3 chr19 Census, Compendium Yes 1 hippie 167 63 10 10 7
JAKMIP1_ENST00000282924 JAKMIP1 Q96N16 Janus kinase and microtubule-interacting protein 1 chr4 Not Cancer Driver No 1 hippie 163 388 118 118 0
KCNC3 KCNC3 Q14003 Potassium voltage-gated channel subfamily C member 3 chr19 Not Cancer Driver No 1 hippie, biogrid 76 405 29 29 4
KCNE3 KCNE3 Q9Y6H6 Potassium voltage-gated channel subfamily E member 3 chr11 Not Cancer Driver No 1 hippie, biogrid 28 24 2 2 0
KIF24 KIF24 Q5T7B8 Kinesin-like protein KIF24 chr9 Not Cancer Driver No 1 hippie 126 898 90 90 0
LAMP2_ENST00000200639 LAMP2 P13473 Lysosome-associated membrane glycoprotein 2 chrX Not Cancer Driver No 2 intact, hippie, biogrid 43 55 7 7 1
LAMP3 LAMP3 Q9UQV4 Lysosome-associated membrane glycoprotein 3 chr3 Not Cancer Driver No 2 intact, hippie, biogrid 67 222 38 38 0
LPAR6_ENST00000620633 LPAR6 P43657 Lysophosphatidic acid receptor 6 chr13 Not Cancer Driver No 3 intact, hippie, biogrid 39 0 0 0 3
LRRIQ1 LRRIQ1 Q96JM4 Leucine-rich repeat and IQ domain-containing protein 1 chr12 Not Cancer Driver No 2 intact, hippie, biogrid 389 884 205 205 0
LTN1_ENST00000361371 LTN1 O94822 E3 ubiquitin-protein ligase listerin chr21 Not Cancer Driver No 1 hippie 192 124 23 23 0
MAGOH MAGOH P61326 Protein mago nashi homolog chr1 Not Cancer Driver No 1 hippie 15 6 0 0 0
MANSC1 MANSC1 Q9H8J5 MANSC domain-containing protein 1 chr12 Not Cancer Driver No 2 intact, hippie, biogrid 53 206 21 21 0
MAS1 MAS1 P04201 Proto-oncogene Mas chr6 Not Cancer Driver No 2 intact, hippie, biogrid 47 5 2 2 0
MDK_ENST00000407067 MDK P21741 Midkine chr11 Not Cancer Driver No 1 hippie 15 20 2 2 0
MDM2_ENST00000539479 MDM2 Q00987 E3 ubiquitin-protein ligase Mdm2 chr12 Census, Compendium Yes 1 hippie 56 297 37 37 0
MFSD4A MFSD4A Q8N468 Major facilitator superfamily domain-containing protein 4A chr1 Not Cancer Driver No 1 hippie 56 29 3 3 0
MGARP MGARP Q8TDB4 Protein MGARP chr4 Not Cancer Driver No 1 hippie, biogrid 25 207 22 22 0
MRAP2 MRAP2 Q96G30 Melanocortin-2 receptor accessory protein 2 chr6 Not Cancer Driver No 1 hippie, biogrid 55 75 17 17 0
NOC2L NOC2L Q9Y3T9 Nucleolar complex protein 2 homolog chr1 Not Cancer Driver No 1 hippie 77 281 31 31 0
NPM1 NPM1 P06748 Nucleophosmin chr5 Census, Compendium Yes 1 hippie 29 249 22 22 0
NTRK1 NTRK1 P04629 High affinity nerve growth factor receptor chr1 Census, Compendium Yes 1 hippie 168 57 8 8 25
OPALIN OPALIN Q96PE5 Opalin chr10 Not Cancer Driver No 1 hippie, biogrid 29 86 18 18 0
OSMR OSMR Q99650 Oncostatin-M-specific receptor subunit beta chr5 Not Cancer Driver No 3 hippie, biogrid 167 145 22 22 5
OSTM1 OSTM1 Q86WC4 Osteopetrosis-associated transmembrane protein 1 chr6 Not Cancer Driver No 1 hippie, biogrid 31 24 4 4 0
P2RY10 P2RY10 O00398 Putative P2Y purinoceptor 10 chrX Not Cancer Driver No 1 hippie, biogrid 113 0 0 0 0
PAGE4_ENST00000376141 PAGE4 O60829 P antigen family member 4 chrX Not Cancer Driver No 1 hippie 20 102 20 20 0
PARP9 PARP9 Q8IXQ6 Protein mono-ADP-ribosyltransferase PARP9 chr3 Not Cancer Driver No 1 hippie 110 45 3 3 0
PCDHA8 PCDHA8 Q9Y5H6 Protocadherin alpha-8 chr5 Not Cancer Driver No 1 hippie, biogrid 344 273 73 73 0
PDCD1 PDCD1 Q15116 Programmed cell death protein 1 chr2 Not Cancer Driver No 1 hippie, biogrid 56 141 37 37 0
PDGFRA PDGFRA P16234 Platelet-derived growth factor receptor alpha chr4 Census, Compendium Yes 1 hippie 290 173 45 45 2
PDGFRB PDGFRB P09619 Platelet-derived growth factor receptor beta chr5 Census, Compendium Yes 1 hippie 164 231 44 44 7
PEBP1 PEBP1 P30086 Phosphatidylethanolamine-binding protein 1 chr12 Not Cancer Driver No 1 hippie 23 76 13 13 0
PIK3R1 PIK3R1 P27986 Phosphatidylinositol 3-kinase regulatory subunit alpha chr5 Census, Compendium Yes 1 hippie 154 268 61 61 2
PLA2G4A PLA2G4A P47712 Cytosolic phospholipase A2 chr1 Not Cancer Driver No 1 hippie 149 129 28 28 1
PLAUR PLAUR Q03405 Urokinase plasminogen activator surface receptor chr19 Not Cancer Driver No 1 hippie 49 18 5 5 0
PLCG1_ENST00000373271 PLCG1 P19174 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 chr20 Census, Compendium Yes 1 hippie 158 186 21 21 0
PLCG2 PLCG2 P16885 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 chr16 Not Cancer Driver No 1 hippie 248 142 30 30 1
PML PML P29590 Protein PML chr15 Census, Compendium Yes 1 hippie 112 312 34 34 0
PRKCA PRKCA P17252 Protein kinase C alpha type chr17 Not Cancer Driver No 1 intact, hippie 94 154 22 22 0
PRKCZ PRKCZ Q05513 Protein kinase C zeta type chr1 Not Cancer Driver No 1 hippie 70 116 11 11 0
PRMT5 PRMT5 O14744 Protein arginine N-methyltransferase 5 chr14 Not Cancer Driver No 1 hippie 83 72 6 6 0
PTH2R PTH2R P49190 Parathyroid hormone 2 receptor chr2 Not Cancer Driver No 1 hippie, biogrid 123 49 17 17 0
PTK2B_ENST00000346049 PTK2B Q14289 Protein-tyrosine kinase 2-beta chr8 Not Cancer Driver No 1 hippie 161 261 37 37 0
PTPN11_ENST00000351677 PTPN11 Q06124 Tyrosine-protein phosphatase non-receptor type 11 chr12 Census, Compendium Yes 1 hippie 129 260 38 38 60
PTPN2 PTPN2 P17706 Tyrosine-protein phosphatase non-receptor type 2 chr18 Not Cancer Driver No 1 hippie 57 120 14 14 0
PTPN6_ENST00000318974 PTPN6 P29350 Tyrosine-protein phosphatase non-receptor type 6 chr12 Census, Compendium Yes 1 hippie 73 192 25 25 0
RAC1_ENST00000348035 RAC1 P63000 Ras-related C3 botulinum toxin substrate 1 chr7 Census, Compendium Yes 1 hippie 66 2 1 1 6
RAC3 RAC3 P60763 Ras-related C3 botulinum toxin substrate 3 chr17 Not Cancer Driver No 1 hippie 24 0 0 0 4
RACK1 RACK1 P63244 Receptor of activated protein C kinase 1 chr5 Not Cancer Driver No 1 hippie 34 13 0 0 0
RAF1 RAF1 P04049 RAF proto-oncogene serine/threonine-protein kinase chr3 Census, Compendium Yes 1 hippie 89 169 38 38 22
RARA RARA P10276 Retinoic acid receptor alpha chr17 Census, Compendium Yes 1 hippie 70 167 14 14 0
RELT RELT Q969Z4 Tumor necrosis factor receptor superfamily member 19L chr11 Not Cancer Driver No 1 hippie, biogrid 48 239 18 18 0
RHOA RHOA P61586 Transforming protein RhoA chr3 Census, Compendium Yes 1 hippie 99 46 13 13 2
RHOB RHOB P62745 Rho-related GTP-binding protein RhoB chr2 Not Cancer Driver No 1 hippie 52 19 2 2 0
RHOC_ENST00000369642 RHOC P08134 Rho-related GTP-binding protein RhoC chr1 Not Cancer Driver No 1 hippie 30 53 7 7 0
RHOG_ENST00000396978 RHOG P84095 Rho-related GTP-binding protein RhoG chr11 Not Cancer Driver No 1 hippie 26 22 5 5 0
RHOH_ENST00000617441 RHOH Q15669 Rho-related GTP-binding protein RhoH chr4 Census Yes 1 hippie 41 12 3 3 0
RHOJ RHOJ Q9H4E5 Rho-related GTP-binding protein RhoJ chr14 Not Cancer Driver No 1 hippie 39 0 0 0 0
RHOQ RHOQ P17081 Rho-related GTP-binding protein RhoQ chr2 Not Cancer Driver No 1 hippie 25 0 0 0 0
RHOU RHOU Q7L0Q8 Rho-related GTP-binding protein RhoU chr1 Not Cancer Driver No 1 hippie 34 63 6 6 0
RND1 RND1 Q92730 Rho-related GTP-binding protein Rho6 chr12 Not Cancer Driver No 1 hippie 45 9 1 1 0
RND2 RND2 P52198 Rho-related GTP-binding protein RhoN chr17 Not Cancer Driver No 1 hippie 19 54 4 4 0
RNF125 RNF125 Q96EQ8 E3 ubiquitin-protein ligase RNF125 chr18 Not Cancer Driver No 1 hippie 35 26 1 1 3
RNF149 RNF149 Q8NC42 E3 ubiquitin-protein ligase RNF149 chr2 Not Cancer Driver No 1 hippie, biogrid 41 102 10 10 0
S100B S100B P04271 Protein S100-B chr21 Not Cancer Driver No 1 hippie, biogrid 17 13 1 1 0
SH2B2 SH2B2 O14492-2 Isoform 2 of SH2B adapter protein 2 chr7 Not Cancer Driver No 1 hippie 46 388 19 19 0
SHB SHB Q15464 SH2 domain-containing adapter protein B chr9 Not Cancer Driver No 1 hippie 56 334 36 36 0
SIRT1 SIRT1 Q96EB6 NAD-dependent protein deacetylase sirtuin-1 chr10 Not Cancer Driver No 1 hippie 70 435 31 31 0
SLC15A1 SLC15A1 P46059 Solute carrier family 15 member 1 chr13 Not Cancer Driver No 2 intact, hippie, biogrid 122 24 7 7 0
SLC18A2_ENST00000644641 SLC18A2 Q05940 Synaptic vesicular amine transporter chr10 Not Cancer Driver No 1 hippie, biogrid 105 23 7 7 1
SLC1A1 SLC1A1 P43005 Excitatory amino acid transporter 3 chr9 Not Cancer Driver No 1 hippie, biogrid 69 17 4 4 1
SMURF1 SMURF1 Q9HCE7 E3 ubiquitin-protein ligase SMURF1 chr7 Not Cancer Driver No 1 hippie 89 256 31 31 0
SNAI1 SNAI1 O95863 Zinc finger protein SNAI1 chr20 Not Cancer Driver No 1 hippie 52 97 11 11 0
SOCS1 SOCS1 O15524 Suppressor of cytokine signaling 1 chr16 Census, Compendium Yes 1 hippie 22 66 3 3 2
SOCS3 SOCS3 O14543 Suppressor of cytokine signaling 3 chr17 Not Cancer Driver No 1 hippie 27 111 14 14 0
SPTAN1_ENST00000372731 SPTAN1 Q13813 Spectrin alpha chain, non-erythrocytic 1 chr9 Not Cancer Driver No 1 intact, hippie 315 980 114 114 0
STAM STAM Q92783 Signal transducing adapter molecule 1 chr10 Not Cancer Driver No 1 hippie 73 361 40 40 0
STAM2 STAM2 O75886 Signal transducing adapter molecule 2 chr2 Not Cancer Driver No 2 intact, hippie 69 291 30 30 0
STAT1 STAT1 P42224 Signal transducer and activator of transcription 1-alpha/beta chr2 Not Cancer Driver No 4 intact, hippie 131 144 25 25 26
STAT2 STAT2 P52630 Signal transducer and activator of transcription 2 chr12 Not Cancer Driver No 1 hippie 90 178 22 22 2
STAT3 STAT3 P40763 Signal transducer and activator of transcription 3 chr17 Census, Compendium Yes 1 hippie 110 152 15 15 19
STAT5A_ENST00000590949 STAT5A P42229 Signal transducer and activator of transcription 5A chr17 Not Cancer Driver No 1 hippie 89 125 14 14 0
STAT5B STAT5B P51692 Signal transducer and activator of transcription 5B chr17 Census, Compendium Yes 1 hippie 93 144 19 19 5
STAT6_ENST00000543873 STAT6 P42226 Signal transducer and activator of transcription 6 chr12 Census, Compendium Yes 1 hippie 106 325 44 44 0
SYK_ENST00000375746 SYK P43405 Tyrosine-protein kinase SYK chr9 Census Yes 1 hippie 96 131 27 27 5
SYT11 SYT11 Q9BT88 Synaptotagmin-11 chr1 Not Cancer Driver No 1 hippie, biogrid 64 105 23 23 0
SYVN1 SYVN1 Q86TM6 E3 ubiquitin-protein ligase synoviolin chr11 Not Cancer Driver No 1 hippie 63 284 32 32 0
TAGLN_ENST00000530649 TAGLN Q01995 Transgelin chr11 Not Cancer Driver No 1 hippie 20 94 12 12 0
TEC TEC P42680 Tyrosine-protein kinase Tec chr4 Census, Compendium Yes 1 hippie 91 57 15 15 0
TENT5A TENT5A Q96IP4 Terminal nucleotidyltransferase 5A chr6 Not Cancer Driver No 1 intact, hippie 43 0 0 0 0
TGFBR2_ENST00000295754 TGFBR2 P37173 TGF-beta receptor type-2 chr3 Census, Compendium Yes 3 intact, hippie, biogrid 106 60 16 16 25
TICAM2 TICAM2 Q86XR7 TIR domain-containing adapter molecule 2 chr5 Not Cancer Driver No 1 biogrid 35 88 10 10 0
TIRAP_ENST00000392680 TIRAP P58753 Toll/interleukin-1 receptor domain-containing adapter protein chr11 Not Cancer Driver No 1 hippie 28 80 6 6 0
TMED7-TICAM2 TMED7-TICAM2 Q86XR7-2 Isoform 2 of TIR domain-containing adapter molecule 2 chr5 Not Cancer Driver No 1 hippie 51 102 14 14 0
TMEM192 TMEM192 Q8IY95 Transmembrane protein 192 chr4 Not Cancer Driver No 1 hippie 31 5 1 1 0
TMEM9_ENST00000485839 TMEM9 Q9P0T7 Proton-transporting V-type ATPase complex assembly regulator TMEM9 chr1 Not Cancer Driver No 1 hippie, biogrid 22 23 3 3 0
TNF TNF P01375 Tumor necrosis factor chr6 Not Cancer Driver No 1 hippie 24 45 3 3 0
TNFRSF1A TNFRSF1A P19438 Tumor necrosis factor receptor superfamily member 1A chr12 Not Cancer Driver No 1 hippie 58 111 15 15 12
TOP1 TOP1 P11387 DNA topoisomerase 1 chr20 Census, Compendium Yes 1 hippie 93 391 53 53 0
TP53_ENST00000445888 TP53 P04637 Cellular tumor antigen p53 chr17 Census, Compendium Yes 1 hippie 2891 282 1466 1466 83
TRIM11 TRIM11 Q96F44 E3 ubiquitin-protein ligase TRIM11 chr1 Not Cancer Driver No 1 hippie 58 132 14 14 0
TRIM66_ENST00000299550 TRIM66 O15016 Tripartite motif-containing protein 66 chr11 Not Cancer Driver No 1 hippie 58 723 32 32 0
TSHR TSHR P16473 Thyrotropin receptor chr14 Census Yes 1 hippie 128 38 9 9 39
TYK2 TYK2 P29597 Non-receptor tyrosine-protein kinase TYK2 chr19 Not Cancer Driver No 1 hippie 148 213 29 29 0
UBL4A UBL4A P11441 Ubiquitin-like protein 4A chrX Not Cancer Driver No 1 hippie 22 16 5 5 0
UFL1 UFL1 O94874 E3 UFM1-protein ligase 1 chr6 Not Cancer Driver No 1 hippie 109 141 24 24 0
USP16 USP16 Q9Y5T5 Ubiquitin carboxyl-terminal hydrolase 16 chr21 Not Cancer Driver No 1 hippie 98 394 42 42 0
USP6 USP6 P35125 Ubiquitin carboxyl-terminal hydrolase 6 chr17 Census, Compendium Yes 1 hippie 243 537 83 83 0
VIRMA VIRMA Q69YN4 Protein virilizer homolog chr8 Not Cancer Driver No 1 hippie 211 631 93 93 0
VSIG4 VSIG4 Q9Y279 V-set and immunoglobulin domain-containing protein 4 chrX Not Cancer Driver No 1 hippie, biogrid 73 70 13 13 0
YWHAE YWHAE P62258 14-3-3 protein epsilon chr17 Census Yes 1 hippie 32 41 3 3 0
ZRANB1 ZRANB1 Q9UGI0 Ubiquitin thioesterase ZRANB1 chr10 Not Cancer Driver No 1 hippie 87 158 25 25 0