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DES ,DES ,P17661
  • Uniprot Accession= P17661
  • Ensembl Transcript= ENST00000373960.3
  • Uniprot Name= DES
  • Name= Desmin
  • Chromosome= chr2
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 40
  • Number of Interaction partner in biogrid: 48
  • Number of Interaction partner in hippie: 134
Identifier
UniProt Gene
UniProt Accession
UniProt Name
Chromosome
Cancer Database
Cancer Driver
Number of independent pubication
Interaction Database
Number of missense mutations
Number of disordered residues
Number of mutations in disordered residues
Number of mutations in disordered residues
Number of omim mutations
ABTB2 ABTB2 Q8N961 Ankyrin repeat and BTB/POZ domain-containing protein 2 chr11 Not Cancer Driver No 1 hippie, biogrid 95 215 20 20 0
ANLN ANLN Q9NQW6 Anillin chr7 Not Cancer Driver No 1 hippie 144 767 104 104 2
ATF2 ATF2 P15336 Cyclic AMP-dependent transcription factor ATF-2 chr2 Not Cancer Driver No 1 intact, hippie 65 451 58 58 0
AURKB_ENST00000585124 AURKB Q96GD4 Aurora kinase B chr17 Not Cancer Driver No 1 hippie 51 63 8 8 0
BAG5_ENST00000299204 BAG5 Q9UL15 BAG family molecular chaperone regulator 5 chr14 Not Cancer Driver No 1 intact, hippie 37 63 7 7 0
BMI1 BMI1 P35226 Polycomb complex protein BMI-1 chr10 Not Cancer Driver No 1 intact, hippie 50 150 30 30 0
BMPR2 BMPR2 Q13873 Bone morphogenetic protein receptor type-2 chr2 Compendium Yes 1 hippie, biogrid 141 601 70 70 19
BRCA1_ENST00000357654 BRCA1 P38398 Breast cancer type 1 susceptibility protein chr17 Census, Compendium Yes 1 hippie 224 1458 174 174 35
C1orf216 C1orf216 Q8TAB5 UPF0500 protein C1orf216 chr1 Not Cancer Driver No 1 intact, hippie 22 199 21 21 0
CAPN1_ENST00000533129 CAPN1 P07384 Calpain-1 catalytic subunit chr11 Not Cancer Driver No 1 hippie 68 32 2 2 1
CARM1 CARM1 Q86X55 Histone-arginine methyltransferase CARM1 chr19 Not Cancer Driver No 1 hippie, biogrid 62 102 10 10 0
CCDC92 CCDC92 Q53HC0 Coiled-coil domain-containing protein 92 chr12 Not Cancer Driver No 1 hippie, biogrid 60 299 49 49 0
CCT7 CCT7 Q99832 T-complex protein 1 subunit eta chr2 Not Cancer Driver No 1 hippie, biogrid 59 36 6 6 0
CDC73 CDC73 Q6P1J9 Parafibromin chr1 Census, Compendium Yes 1 hippie, biogrid 110 210 39 39 2
CFTR CFTR P13569 Cystic fibrosis transmembrane conductance regulator chr7 Not Cancer Driver No 1 hippie 287 145 18 18 151
CHMP4B CHMP4B Q9H444 Charged multivesicular body protein 4b chr20 Not Cancer Driver No 1 hippie 25 201 22 22 2
CIT_ENST00000261833 CIT O14578 Citron Rho-interacting kinase chr12 Not Cancer Driver No 1 hippie 284 1017 160 160 3
CLIP4 CLIP4 Q8N3C7 CAP-Gly domain-containing linker protein 4 chr2 Not Cancer Driver No 1 hippie 112 287 61 61 0
CRYAB_ENST00000616970 CRYAB P02511 Alpha-crystallin B chain chr11 Not Cancer Driver No 1 hippie 22 59 11 11 4
CT55 CT55 Q8WUE5 Cancer/testis antigen 55 chrX Not Cancer Driver No 1 intact, hippie 42 40 3 3 0
CUL4A CUL4A Q13619 Cullin-4A chr13 Not Cancer Driver No 1 hippie 64 102 2 2 0
CWF19L2 CWF19L2 Q2TBE0 CWF19-like protein 2 chr11 Not Cancer Driver No 1 intact, hippie 119 615 83 83 0
DDX6 DDX6 P26196 Probable ATP-dependent RNA helicase DDX6 chr11 Census, Compendium Yes 1 intact, hippie 44 129 7 7 5
DES DES P17661 Desmin chr2 Not Cancer Driver No 2 intact, hippie 71 264 41 41 35
DLST DLST P36957 Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial chr14 Not Cancer Driver No 1 intact, hippie, biogrid 53 190 32 32 1
DSP DSP P15924 Desmoplakin chr6 Not Cancer Driver No 1 hippie 483 1124 204 204 6
DTNA_ENST00000444659 DTNA Q9Y4J8 Dystrobrevin alpha chr18 Not Cancer Driver No 1 hippie 162 412 86 86 0
DYSF_ENST00000258104 DYSF O75923 Dysferlin chr2 Not Cancer Driver No 1 hippie 467 329 64 64 55
ECT2 ECT2 Q9H8V3 Protein ECT2 chr3 Not Cancer Driver No 1 hippie 104 284 33 33 0
EHHADH EHHADH Q08426 Peroxisomal bifunctional enzyme chr3 Not Cancer Driver No 2 intact, hippie 116 74 14 14 1
ENO1 ENO1 P06733 Alpha-enolase chr1 Not Cancer Driver No 1 intact, hippie 51 21 2 2 0
ERC1 ERC1 Q8IUD2 ELKS/Rab6-interacting/CAST family member 1 chr12 Census Yes 1 hippie, biogrid 127 1013 119 119 0
GAN GAN Q9H2C0 Gigaxonin chr16 Not Cancer Driver No 1 hippie, biogrid 74 33 6 6 19
GFAP_ENST00000588735 GFAP P14136 Glial fibrillary acidic protein chr17 Not Cancer Driver No 5 intact, hippie, biogrid 65 288 42 42 62
GLI1 GLI1 P08151 Zinc finger protein GLI1 chr12 Census, Compendium Yes 1 intact, hippie 206 1015 184 184 0
HADHB HADHB P55084 Trifunctional enzyme subunit beta, mitochondrial chr2 Not Cancer Driver No 1 hippie, biogrid 71 41 9 9 14
HNRNPUL1 HNRNPUL1 Q9BUJ2 Heterogeneous nuclear ribonucleoprotein U-like protein 1 chr19 Not Cancer Driver No 1 hippie, biogrid 100 535 49 49 0
HSPB1 HSPB1 P04792 Heat shock protein beta-1 chr7 Not Cancer Driver No 1 intact, hippie 10 118 8 8 20
HTT HTT P42858 Huntingtin chr4 Not Cancer Driver No 1 intact, hippie 336 666 69 69 2
IFT57 IFT57 Q9NWB7 Intraflagellar transport protein 57 homolog chr3 Not Cancer Driver No 1 hippie 46 219 18 18 0
INA INA Q16352 Alpha-internexin chr10 Not Cancer Driver No 1 hippie, biogrid 62 256 43 43 0
ITSN1 ITSN1 Q15811 Intersectin-1 chr21 Not Cancer Driver No 1 hippie 214 797 107 107 0
JPH3 JPH3 Q8WXH2 Junctophilin-3 chr16 Not Cancer Driver No 1 hippie 130 534 92 92 0
JUN JUN P05412 Transcription factor Jun chr1 Census Yes 1 hippie 35 281 25 25 0
JUP JUP P14923 Junction plakoglobin chr17 Not Cancer Driver No 1 hippie, biogrid 112 241 37 37 0
KIF14 KIF14 Q15058 Kinesin-like protein KIF14 chr1 Not Cancer Driver No 1 hippie 222 774 102 102 2
KIF1C KIF1C O43896 Kinesin-like protein KIF1C chr17 Not Cancer Driver No 1 hippie, biogrid 131 695 94 94 1
KIF20A KIF20A O95235 Kinesin-like protein KIF20A chr5 Not Cancer Driver No 1 hippie 79 340 40 40 1
KIF23 KIF23 Q02241 Kinesin-like protein KIF23 chr15 Not Cancer Driver No 1 hippie 102 559 62 62 0
KLHL22 KLHL22 Q53GT1 Kelch-like protein 22 chr22 Not Cancer Driver No 1 hippie, biogrid 90 50 8 8 0
KRT13 KRT13 P13646 Keratin, type I cytoskeletal 13 chr17 Not Cancer Driver No 1 intact, hippie 90 180 29 29 5
KRT15_ENST00000393976 KRT15 P19012 Keratin, type I cytoskeletal 15 chr17 Not Cancer Driver No 1 intact, hippie 95 191 34 34 0
KRT20 KRT20 P35900 Keratin, type I cytoskeletal 20 chr17 Not Cancer Driver No 1 hippie 68 171 31 31 0
KRT33B KRT33B Q14525 Keratin, type I cuticular Ha3-II chr17 Not Cancer Driver No 1 hippie 87 59 18 18 0
KRT37 KRT37 O76014 Keratin, type I cuticular Ha7 chr17 Not Cancer Driver No 1 hippie 105 80 18 18 0
KRT73 KRT73 Q86Y46 Keratin, type II cytoskeletal 73 chr12 Not Cancer Driver No 1 hippie, biogrid 121 60 14 14 0
KRT75 KRT75 O95678 Keratin, type II cytoskeletal 75 chr12 Not Cancer Driver No 1 intact, hippie 126 142 35 35 1
LATS1 LATS1 O95835 Serine/threonine-protein kinase LATS1 chr6 Census, Compendium Yes 1 hippie, biogrid 161 788 100 100 0
LBX1 LBX1 P52954 Transcription factor LBX1 chr10 Not Cancer Driver No 1 hippie 26 181 18 18 0
LENG1 LENG1 Q96BZ8 Leukocyte receptor cluster member 1 chr19 Not Cancer Driver No 1 intact, hippie 39 264 39 39 0
LMO4 LMO4 P61968 LIM domain transcription factor LMO4 chr1 Not Cancer Driver No 1 hippie 30 11 1 1 0
LONRF3 LONRF3 Q496Y0 LON peptidase N-terminal domain and RING finger protein 3 chrX Not Cancer Driver No 1 hippie 105 262 36 36 0
M1AP M1AP Q8TC57 Meiosis 1 arrest protein chr2 Not Cancer Driver No 1 intact, hippie 81 157 27 27 0
MAPKAPK2 MAPKAPK2 P49137 MAP kinase-activated protein kinase 2 chr1 Not Cancer Driver No 1 hippie 43 92 5 5 0
MECOM_ENST00000494292 MECOM Q03112 Histone-lysine N-methyltransferase MECOM chr3 Census, Compendium Yes 1 hippie, biogrid 287 749 159 159 3
MLH1 MLH1 P40692 DNA mismatch repair protein Mlh1 chr3 Census Yes 1 hippie 92 208 22 22 85
MOV10_ENST00000357443 MOV10 Q9HCE1 Helicase MOV-10 chr1 Not Cancer Driver No 1 hippie 110 101 8 8 0
MRPS5 MRPS5 P82675 28S ribosomal protein S5, mitochondrial chr2 Not Cancer Driver No 1 hippie, biogrid 52 157 20 20 0
MTM1 MTM1 Q13496 Myotubularin chrX Not Cancer Driver No 1 intact, hippie 112 79 9 9 57
MYL6_ENST00000548293 MYL6 P60660 Myosin light polypeptide 6 chr12 Not Cancer Driver No 1 hippie, biogrid 13 17 1 1 0
NEB_ENST00000172853 NEB P20929 Nebulin chr2 Not Cancer Driver No 1 hippie 1188 1984 355 355 0
NEFL NEFL P07196 Neurofilament light polypeptide chr8 Not Cancer Driver No 2 hippie, biogrid 92 285 39 39 12
NEFM NEFM P07197 Neurofilament medium polypeptide chr8 Not Cancer Driver No 2 intact, hippie, biogrid 182 767 147 147 0
NEK6_ENST00000545174 NEK6 Q9HC98 Serine/threonine-protein kinase Nek6 chr9 Not Cancer Driver No 1 hippie 31 36 0 0 0
NES NES P48681 Nestin chr1 Not Cancer Driver No 1 hippie, biogrid 271 1474 253 253 0
NSF NSF P46459 Vesicle-fusing ATPase chr17 Not Cancer Driver No 1 hippie, biogrid 47 84 3 3 2
NUP88 NUP88 Q99567 Nuclear pore complex protein Nup88 chr17 Not Cancer Driver No 1 hippie, biogrid 86 147 25 25 1
PABPC4_ENST00000372857 PABPC4 Q13310 Polyadenylate-binding protein 4 chr1 Not Cancer Driver No 1 hippie 89 253 49 49 0
PDHA1_ENST00000422285 PDHA1 P08559 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial chrX Not Cancer Driver No 1 hippie, biogrid 70 43 6 6 20
PIAS2 PIAS2 O75928 E3 SUMO-protein ligase PIAS2 chr18 Not Cancer Driver No 1 hippie 78 209 28 28 0
PIH1D2 PIH1D2 Q8WWB5 PIH1 domain-containing protein 2 chr11 Not Cancer Driver No 1 intact, hippie 33 55 5 5 0
PKD1 PKD1 P98161 Polycystin-1 chr16 Not Cancer Driver No 1 hippie 393 690 66 66 92
PLEKHA5_ENST00000299275 PLEKHA5 Q9HAU0 Pleckstrin homology domain-containing family A member 5 chr12 Not Cancer Driver No 1 hippie 144 869 114 114 0
PMPCA PMPCA Q10713 Mitochondrial-processing peptidase subunit alpha chr9 Not Cancer Driver No 1 hippie, biogrid 67 23 3 3 4
PMPCB PMPCB O75439 Mitochondrial-processing peptidase subunit beta chr7 Not Cancer Driver No 1 hippie, biogrid 55 22 3 3 5
POLR2G POLR2G P62487 DNA-directed RNA polymerase II subunit RPB7 chr11 Not Cancer Driver No 1 intact, hippie 15 15 1 1 0
PPL PPL O60437 Periplakin chr16 Not Cancer Driver No 1 intact, hippie 219 1133 133 133 0
PPP1R18_ENST00000615527 PPP1R18 Q6NYC8 Phostensin chr6 Not Cancer Driver No 3 intact, hippie 51 585 49 49 0
PRC1 PRC1 O43663 Protein regulator of cytokinesis 1 chr15 Not Cancer Driver No 1 hippie 63 235 26 26 0
PRPH PRPH P41219 Peripherin chr12 Not Cancer Driver No 3 intact, hippie, biogrid 37 239 20 20 0
PTBP3_ENST00000374255 PTBP3 O95758 Polypyrimidine tract-binding protein 3 chr9 Not Cancer Driver No 1 intact, hippie 61 114 9 9 0
RAB27B RAB27B O00194 Ras-related protein Rab-27B chr18 Not Cancer Driver No 1 hippie, biogrid 42 43 9 9 0
RBM39 RBM39 Q14498 RNA-binding protein 39 chr20 Compendium Yes 1 hippie 81 228 39 39 0
RNF214_ENST00000531452 RNF214 Q8ND24 RING finger protein 214 chr11 Not Cancer Driver No 1 hippie, biogrid 84 528 66 66 0
RNF4 RNF4 P78317 E3 ubiquitin-protein ligase RNF4 chr4 Not Cancer Driver No 1 hippie 14 117 7 7 0
ROCK1 ROCK1 Q13464 Rho-associated protein kinase 1 chr18 Not Cancer Driver No 1 hippie 184 780 103 103 0
RPL17_ENST00000579248 RPL17 P18621 60S ribosomal protein L17 chr18 Not Cancer Driver No 1 hippie, biogrid 26 97 14 14 0
RPL29_ENST00000475248 RPL29 P47914 60S ribosomal protein L29 chr3 Not Cancer Driver No 1 hippie, biogrid 9 159 9 9 0
RPL34_ENST00000502534 RPL34 P49207 60S ribosomal protein L34 chr4 Not Cancer Driver No 1 hippie, biogrid 11 31 1 1 0
RSPH6A RSPH6A Q9H0K4 Radial spoke head protein 6 homolog A chr19 Not Cancer Driver No 1 hippie, biogrid 129 483 94 94 0
RTN1 RTN1 Q16799 Reticulon-1 chr14 Not Cancer Driver No 1 hippie, biogrid 177 573 134 134 0
S100A1 S100A1 P23297 Protein S100-A1 chr1 Not Cancer Driver No 1 hippie 13 9 0 0 0
S100B S100B P04271 Protein S100-B chr21 Not Cancer Driver No 1 hippie 17 13 1 1 0
SAP18_ENST00000607003 SAP18 O00422 Histone deacetylase complex subunit SAP18 chr13 Not Cancer Driver No 1 hippie 18 99 14 14 0
SHBG SHBG P04278 Sex hormone-binding globulin chr17 Not Cancer Driver No 1 hippie 51 89 9 9 0
SLC47A1 SLC47A1 Q96FL8 Multidrug and toxin extrusion protein 1 chr17 Not Cancer Driver No 1 hippie, biogrid 65 63 7 7 0
SMURF2 SMURF2 Q9HAU4 E3 ubiquitin-protein ligase SMURF2 chr17 Not Cancer Driver No 1 intact, hippie 87 242 28 28 0
SNAPIN SNAPIN O95295 SNARE-associated protein Snapin chr1 Not Cancer Driver No 1 intact, hippie 9 62 5 5 0
SNRNP70 SNRNP70 P08621 U1 small nuclear ribonucleoprotein 70 kDa chr19 Not Cancer Driver No 1 hippie, biogrid 38 416 37 37 0
SOD1 SOD1 P00441 Superoxide dismutase [Cu-Zn] chr21 Not Cancer Driver No 1 hippie, biogrid 16 93 9 9 79
SP1 SP1 P08047 Transcription factor Sp1 chr12 Not Cancer Driver No 1 hippie 96 599 71 71 0
SPATA22_ENST00000397168 SPATA22 Q8NHS9 Spermatogenesis-associated protein 22 chr17 Not Cancer Driver No 2 intact, hippie, biogrid 71 220 40 40 0
SPATA24 SPATA24 Q86W54 Spermatogenesis-associated protein 24 chr5 Not Cancer Driver No 1 hippie, biogrid 9 58 0 0 0
SPRTN SPRTN Q9H040 DNA-dependent metalloprotease SPRTN chr1 Not Cancer Driver No 1 hippie 73 252 38 38 1
SPTAN1_ENST00000372731 SPTAN1 Q13813 Spectrin alpha chain, non-erythrocytic 1 chr9 Not Cancer Driver No 1 hippie 315 980 114 114 0
STAT1 STAT1 P42224 Signal transducer and activator of transcription 1-alpha/beta chr2 Not Cancer Driver No 1 intact, hippie 131 144 25 25 26
SYCE1_ENST00000343131 SYCE1 Q8N0S2 Synaptonemal complex central element protein 1 chr10 Not Cancer Driver No 1 hippie, biogrid 70 251 50 50 0
SYNC SYNC Q9H7C4 Syncoilin chr1 Not Cancer Driver No 3 intact, hippie, biogrid 30 358 22 22 0
SYNM SYNM O15061 Synemin chr15 Not Cancer Driver No 2 hippie, biogrid 156 1244 131 131 0
TCEA2 TCEA2 Q15560 Transcription elongation factor A protein 2 chr20 Not Cancer Driver No 1 hippie 45 194 40 40 0
TFIP11_ENST00000407148 TFIP11 Q9UBB9 Tuftelin-interacting protein 11 chr22 Not Cancer Driver No 1 intact, hippie 87 331 39 39 0
TRIM55 TRIM55 Q9BYV6 Tripartite motif-containing protein 55 chr8 Not Cancer Driver No 1 hippie 134 276 78 78 0
TRIM63 TRIM63 Q969Q1 E3 ubiquitin-protein ligase TRIM63 chr1 Not Cancer Driver No 1 hippie 47 71 13 13 0
TRIM7 TRIM7 Q9C029 E3 ubiquitin-protein ligase TRIM7 chr5 Not Cancer Driver No 1 hippie 60 145 12 12 0
TSPAN33 TSPAN33 Q86UF1 Tetraspanin-33 chr7 Not Cancer Driver No 1 hippie, biogrid 26 0 0 0 0
UBD UBD O15205 Ubiquitin D chr6 Not Cancer Driver No 1 hippie 31 8 1 1 0
UBE2I UBE2I P63279 SUMO-conjugating enzyme UBC9 chr16 Not Cancer Driver No 1 intact, hippie 16 16 3 3 0
USP11 USP11 P51784 Ubiquitin carboxyl-terminal hydrolase 11 chrX Not Cancer Driver No 1 hippie 140 210 28 28 0
VCP VCP P55072 Transitional endoplasmic reticulum ATPase chr9 Not Cancer Driver No 1 hippie, biogrid 88 186 16 16 16
VIM_ENST00000224237 VIM P08670 Vimentin chr10 Not Cancer Driver No 3 intact, hippie, biogrid 84 316 57 57 1
YES1_ENST00000314574 YES1 P07947 Tyrosine-protein kinase Yes chr18 Not Cancer Driver No 1 hippie 65 62 10 10 0
YWHAQ YWHAQ P27348 14-3-3 protein theta chr2 Not Cancer Driver No 1 hippie 29 41 6 6 0
YWHAZ_ENST00000395956 YWHAZ P63104 14-3-3 protein zeta/delta chr8 Not Cancer Driver No 1 intact, hippie 30 81 10 10 0
ZMYM5_ENST00000337963 ZMYM5 Q9UJ78 Zinc finger MYM-type protein 5 chr13 Not Cancer Driver No 1 intact, hippie 67 374 40 40 0