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VAV3 ,VAV3 ,Q9UKW4
  • Uniprot Accession= Q9UKW4
  • Ensembl Transcript= ENST00000370056.8
  • Uniprot Name= VAV3
  • Name= Guanine nucleotide exchange factor VAV3
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 99
GO term GO name GO namespace GO def
GO:0048584 positive regulation of response to stimulus biological_process Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. [GOC:jid]
GO:0070851 growth factor receptor binding molecular_function Binding to a growth factor receptor. [GOC:mah, GOC:vw]
GO:0016477 cell migration biological_process The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms. [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]
GO:0050789 regulation of biological process biological_process Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. [GOC:ai, GOC:go_curators]
GO:0019222 regulation of metabolic process biological_process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. [GOC:go_curators]
GO:0050778 positive regulation of immune response biological_process Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. [GOC:ai]
GO:0030888 regulation of B cell proliferation biological_process Any process that modulates the frequency, rate or extent of B cell proliferation. [GOC:mah]
GO:0048583 regulation of response to stimulus biological_process Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. [GOC:jid]
GO:0050794 regulation of cellular process biological_process Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. [GOC:go_curators]
GO:0042325 regulation of phosphorylation biological_process Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule. [GOC:jl]
GO:0005096 GTPase activator activity molecular_function Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. [GOC:mah]
GO:0050867 positive regulation of cell activation biological_process Any process that activates or increases the frequency, rate or extent of activation. [GOC:ai]
GO:0050776 regulation of immune response biological_process Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. [GOC:ai]
GO:0051249 regulation of lymphocyte activation biological_process Any process that modulates the frequency, rate or extent of lymphocyte activation. [GOC:ai]
GO:0071621 granulocyte chemotaxis biological_process The movement of a granulocyte in response to an external stimulus. [GOC:rph]
GO:0008284 positive regulation of cell population proliferation biological_process Any process that activates or increases the rate or extent of cell proliferation. [GOC:go_curators]
GO:0032535 regulation of cellular component size biological_process A process that modulates the size of a cellular component. [GOC:mah]
GO:0019220 regulation of phosphate metabolic process biological_process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates. [GOC:go_curators]
GO:0050790 regulation of catalytic activity biological_process Any process that modulates the activity of an enzyme. [GOC:ai, GOC:ebc, GOC:vw]
GO:0030168 platelet activation biological_process A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug. [http://www.graylab.ac.uk/omd/]
GO:0042127 regulation of cell population proliferation biological_process Any process that modulates the frequency, rate or extent of cell proliferation. [GOC:jl]
GO:0016043 cellular component organization biological_process A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. [GOC:ai, GOC:jl, GOC:mah]
GO:0007166 cell surface receptor signaling pathway biological_process A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription. [GOC:bf, GOC:mah, GOC:pr, GOC:signaling]
GO:0031325 positive regulation of cellular metabolic process biological_process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. [GOC:mah]
GO:0120031 plasma membrane bounded cell projection assembly biological_process Formation of a prolongation or process extending and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon. [GOC:krc]
GO:0048870 cell motility biological_process Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another. [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg]
GO:0019216 regulation of lipid metabolic process biological_process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids. [GOC:go_curators]
GO:0002429 immune response-activating cell surface receptor signaling pathway biological_process A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a cell capable of activating or perpetuating an immune response. [GO_REF:0000022, GOC:add, ISBN:0781735149]
GO:0071840 cellular component organization or biogenesis biological_process A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component. [GOC:mah]
GO:0051347 positive regulation of transferase activity biological_process Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor. [GOC:ai]
GO:0005085 guanyl-nucleotide exchange factor activity molecular_function Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]
GO:0007229 integrin-mediated signaling pathway biological_process A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling]
GO:0080090 regulation of primary metabolic process biological_process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. [PMID:19211694]
GO:0097530 granulocyte migration biological_process The movement of a granulocyte within or between different tissues and organs of the body. [GOC:cvs, PMID:24163421, PMID:24193336]
GO:0005829 cytosol cellular_component The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
GO:0002684 positive regulation of immune system process biological_process Any process that activates or increases the frequency, rate, or extent of an immune system process. [GOC:add]
GO:0060326 cell chemotaxis biological_process The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). [GOC:dph]
GO:0042327 positive regulation of phosphorylation biological_process Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule. [GOC:jl]
GO:0048522 positive regulation of cellular process biological_process Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. [GOC:jid]
GO:0030030 cell projection organization biological_process A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon. [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/]
GO:0050853 B cell receptor signaling pathway biological_process A series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell. [GOC:add]
GO:0051056 regulation of small GTPase mediated signal transduction biological_process Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction. [GOC:go_curators]
GO:0051174 regulation of phosphorus metabolic process biological_process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus. [GOC:ai]
GO:0006935 chemotaxis biological_process The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). [ISBN:0198506732]
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0002252 immune effector process biological_process Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation. [GO_REF:0000022, GOC:add, ISBN:0781735149]
GO:0006928 movement of cell or subcellular component biological_process The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore. [GOC:dgh, GOC:dph, GOC:jl, GOC:mlg]
GO:0051251 positive regulation of lymphocyte activation biological_process Any process that activates or increases the frequency, rate or extent of lymphocyte activation. [GOC:ai]
GO:0043085 positive regulation of catalytic activity biological_process Any process that activates or increases the activity of an enzyme. [GOC:ebc, GOC:jl, GOC:tb, GOC:vw]
GO:0051338 regulation of transferase activity biological_process Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. [GOC:ai]
GO:0009987 cellular process biological_process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. [GOC:go_curators, GOC:isa_complete]
GO:0070663 regulation of leukocyte proliferation biological_process Any process that modulates the frequency, rate or extent of leukocyte proliferation. [GOC:add, GOC:mah]
GO:1990266 neutrophil migration biological_process The movement of a neutrophil within or between different tissues and organs of the body. [PMID:1826836]
GO:0045785 positive regulation of cell adhesion biological_process Any process that activates or increases the frequency, rate or extent of cell adhesion. [GOC:go_curators]
GO:0044093 positive regulation of molecular function biological_process Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. [GO:jl]
GO:0030595 leukocyte chemotaxis biological_process The movement of a leukocyte in response to an external stimulus. [GOC:add, GOC:jl]
GO:0002696 positive regulation of leukocyte activation biological_process Any process that activates or increases the frequency, rate, or extent of leukocyte activation. [GOC:add]
GO:0005102 signaling receptor binding molecular_function Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:bf, GOC:ceb, ISBN:0198506732]
GO:0065007 biological regulation biological_process Any process that modulates a measurable attribute of any biological process, quality or function. [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]
GO:0065009 regulation of molecular function biological_process Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. [GOC:isa_complete]
GO:0022607 cellular component assembly biological_process The aggregation, arrangement and bonding together of a cellular component. [GOC:isa_complete]
GO:0030031 cell projection assembly biological_process Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon. [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/]
GO:0042221 response to chemical biological_process Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus. [GOC:jl]
GO:0002757 immune response-activating signal transduction biological_process The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to activation or perpetuation of an immune response. [GOC:add]
GO:0006906 vesicle fusion biological_process Fusion of the membrane of a transport vesicle with its target membrane. [GOC:jid]
GO:0046872 metal ion binding molecular_function Binding to a metal ion. [GOC:ai]
GO:0002764 immune response-regulating signaling pathway biological_process The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to the activation, perpetuation, or inhibition of an immune response. [GOC:add, ISBN:0781735149, PMID:15771571]
GO:0007264 small GTPase mediated signal transduction biological_process Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. [GOC:mah]
GO:0033674 positive regulation of kinase activity biological_process Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. [GOC:mah]
GO:0045937 positive regulation of phosphate metabolic process biological_process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates. [GOC:go_curators]
GO:0043549 regulation of kinase activity biological_process Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. [GOC:bf]
GO:0097529 myeloid leukocyte migration biological_process The movement of a myeloid leukocyte within or between different tissues and organs of the body. [GOC:cvs, PMID:22342843, PMID:24157461]
GO:0031323 regulation of cellular metabolic process biological_process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. [GOC:mah]
GO:0050865 regulation of cell activation biological_process Any process that modulates the frequency, rate or extent of cell activation, the change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand. [GOC:ai]
GO:0043087 regulation of GTPase activity biological_process Any process that modulates the rate of GTP hydrolysis by a GTPase. [GOC:jl, GOC:mah]
GO:0007165 signal transduction biological_process The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11]
GO:0005488 binding molecular_function The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. [GOC:ceb, GOC:mah, ISBN:0198506732]
GO:0050896 response to stimulus biological_process Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. [GOC:ai, GOC:bf]
GO:0002376 immune system process biological_process Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats. [GO_REF:0000022, GOC:add]
GO:0090066 regulation of anatomical structure size biological_process Any process that modulates the size of an anatomical structure. [GOC:dph, GOC:tb]
GO:0002253 activation of immune response biological_process Any process that initiates an immune response. [GO_REF:0000022, GOC:add, ISBN:0781735149]
GO:0065008 regulation of biological quality biological_process Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc. [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]
GO:0050670 regulation of lymphocyte proliferation biological_process Any process that modulates the frequency, rate or extent of lymphocyte proliferation. [GOC:ai]
GO:0006974 cellular response to DNA damage stimulus biological_process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. [GOC:go_curators]
GO:0002682 regulation of immune system process biological_process Any process that modulates the frequency, rate, or extent of an immune system process. [GOC:add]
GO:0005737 cytoplasm cellular_component The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
GO:0010562 positive regulation of phosphorus metabolic process biological_process Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus. [GOC:dph, GOC:tb]
GO:0009893 positive regulation of metabolic process biological_process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. [GOC:go_curators]
GO:0050900 leukocyte migration biological_process The movement of a leukocyte within or between different tissues and organs of the body. [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]
GO:0048518 positive regulation of biological process biological_process Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. [GOC:jid]
GO:0032944 regulation of mononuclear cell proliferation biological_process Any process that modulates the frequency, rate or extent of mononuclear cell proliferation. [GOC:add]
GO:0120036 plasma membrane bounded cell projection organization biological_process A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasma membrane bounded prolongation or process extending from a cell, e.g. a cilium or axon. [GOC:krc]
GO:0040011 locomotion biological_process Self-propelled movement of a cell or organism from one location to another. [GOC:dgh]
GO:0042330 taxis biological_process The directed movement of a motile cell or organism in response to an external stimulus. [GOC:jl, ISBN:0192801023]
GO:0001525 angiogenesis biological_process Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. [ISBN:0878932453]
GO:0002768 immune response-regulating cell surface receptor signaling pathway biological_process A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response. [GOC:add, ISBN:0781735149, PMID:15771571]
GO:0005886 plasma membrane cellular_component The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
GO:0110165 cellular anatomical entity cellular_component A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex. [GOC:kmv]
GO:0002694 regulation of leukocyte activation biological_process Any process that modulates the frequency, rate, or extent of leukocyte activation. [GOC:add]