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Total number of protein in "GO:0097746" GO term:  131

Identifier UniProt Gene UniProt Accession UniProt Name Chromosome GO term Database Cancer Driver Number of missense mutations Missense mutation per residues Number of disordered residues Number of mutations in disordered regions Disordered missense mutations per residues Number of OMIM mutation
ABL1_ENST00000318560 ABL1 P00519 Tyrosine-protein kinase ABL1 chr9 GO:0097746 Census, Compendium Yes 139 0.123 604 73 0.121 2
ACE ACE P12821 Angiotensin-converting enzyme chr17 GO:0097746 Not Cancer Driver No 201 0.154 86 8 0.093 0
ACE2 ACE2 Q9BYF1 Angiotensin-converting enzyme 2 chrX GO:0097746 Not Cancer Driver No 104 0.129 68 5 0.074 0
ACTA2 ACTA2 P62736 Actin, aortic smooth muscle chr10 GO:0097746 Not Cancer Driver No 50 0.133 39 4 0.103 17
ADCY6 ADCY6 O43306 Adenylate cyclase type 6 chr12 GO:0097746 Not Cancer Driver No 144 0.123 147 17 0.116 1
ADM ADM P35318 Pro-adrenomedullin chr11 GO:0097746 Not Cancer Driver No 20 0.108 113 13 0.115 0
ADORA2A ADORA2A P29274 Adenosine receptor A2a chr22 GO:0097746 Not Cancer Driver No 61 0.148 93 11 0.118 0
ADORA2B ADORA2B P29275 Adenosine receptor A2b chr17 GO:0097746 Not Cancer Driver No 23 0.069 0 0 0.0 0
ADRA1A_ENST00000380573 ADRA1A P35348 Alpha-1A adrenergic receptor chr8 GO:0097746 Not Cancer Driver No 130 0.279 40 8 0.2 0
ADRA1B ADRA1B P35368 Alpha-1B adrenergic receptor chr5 GO:0097746 Not Cancer Driver No 53 0.102 132 1 0.008 0
ADRA1D ADRA1D P25100 Alpha-1D adrenergic receptor chr20 GO:0097746 Not Cancer Driver No 62 0.108 189 19 0.101 0
ADRA2A ADRA2A P08913 Alpha-2A adrenergic receptor chr10 GO:0097746 Not Cancer Driver No 67 0.144 161 10 0.062 0
ADRA2B ADRA2B P18089 Alpha-2B adrenergic receptor chr2 GO:0097746 Not Cancer Driver No 73 0.162 136 20 0.147 0
ADRA2C ADRA2C P18825 Alpha-2C adrenergic receptor chr4 GO:0097746 Not Cancer Driver No 47 0.102 107 0 0.0 0
ADRB1 ADRB1 P08588 Beta-1 adrenergic receptor chr10 GO:0097746 Not Cancer Driver No 35 0.073 116 1 0.009 0
ADRB2 ADRB2 P07550 Beta-2 adrenergic receptor chr5 GO:0097746 Not Cancer Driver No 52 0.126 35 4 0.114 0
ADRB3 ADRB3 P13945 Beta-3 adrenergic receptor chr8 GO:0097746 Not Cancer Driver No 40 0.098 44 6 0.136 0
AGT AGT P01019 Angiotensinogen chr1 GO:0097746 Not Cancer Driver No 85 0.179 33 10 0.303 1
AGTR1_ENST00000349243 AGTR1 P30556 Type-1 angiotensin II receptor chr3 GO:0097746 Not Cancer Driver No 95 0.265 0 0 0.0 1
AGTR2 AGTR2 P50052 Type-2 angiotensin II receptor chrX GO:0097746 Not Cancer Driver No 98 0.27 0 0 0.0 0
APOE APOE P02649 Apolipoprotein E chr19 GO:0097746 Not Cancer Driver No 25 0.079 124 6 0.048 12
ARHGAP42 ARHGAP42 A6NI28 Rho GTPase-activating protein 42 chr11 GO:0097746 Not Cancer Driver No 63 0.072 311 17 0.055 0
ASIC2_ENST00000359872 ASIC2 Q16515 Acid-sensing ion channel 2 chr17 GO:0097746 Not Cancer Driver No 101 0.197 49 1 0.02 0
ATG5_ENST00000343245 ATG5 Q9H1Y0 Autophagy protein 5 chr6 GO:0097746 Not Cancer Driver No 40 0.145 25 6 0.24 1
ATP1A2 ATP1A2 P50993 Sodium/potassium-transporting ATPase subunit alpha-2 chr1 GO:0097746 Not Cancer Driver No 230 0.225 161 34 0.211 8
ATP2B1_ENST00000261173 ATP2B1 P20020 Plasma membrane calcium-transporting ATPase 1 chr12 GO:0097746 Not Cancer Driver No 143 0.117 293 42 0.143 0
AVP AVP P01185 Vasopressin-neurophysin 2-copeptin chr20 GO:0097746 Not Cancer Driver No 14 0.085 26 0 0.0 39
AVPR1A AVPR1A P37288 Vasopressin V1a receptor chr12 GO:0097746 Not Cancer Driver No 105 0.251 68 25 0.368 0
AVPR1B AVPR1B P47901 Vasopressin V1b receptor chr1 GO:0097746 Not Cancer Driver No 83 0.196 51 5 0.098 0
AVPR2_ENST00000337474 AVPR2 P30518 Vasopressin V2 receptor chrX GO:0097746 Not Cancer Driver No 58 0.156 56 7 0.125 84
BDKRB2 BDKRB2 P30411 B2 bradykinin receptor chr14 GO:0097746 Not Cancer Driver No 81 0.207 0 0 0.0 0
BMPR2 BMPR2 Q13873 Bone morphogenetic protein receptor type-2 chr2 GO:0097746 Compendium Yes 141 0.136 601 70 0.116 19
CASR_ENST00000638421 CASR P41180 Extracellular calcium-sensing receptor chr3 GO:0097746 Not Cancer Driver No 304 0.282 189 60 0.317 108
CAV1 CAV1 Q03135 Caveolin-1 chr7 GO:0097746 Not Cancer Driver No 30 0.169 2 0 0.0 0
CD38 CD38 P28907 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 chr4 GO:0097746 Not Cancer Driver No 54 0.18 3 1 0.333 0
CHRM3_ENST00000615928 CHRM3 P20309 Muscarinic acetylcholine receptor M3 chr1 GO:0097746 Not Cancer Driver No 182 0.308 136 42 0.309 0
COMP COMP P49747 Cartilage oligomeric matrix protein chr19 GO:0097746 Not Cancer Driver No 97 0.128 306 52 0.17 61
CPS1_ENST00000233072 CPS1 P31327 Carbamoyl-phosphate synthase [ammonia], mitochondrial chr2 GO:0097746 Not Cancer Driver No 368 0.245 73 22 0.301 140
CRP CRP P02741 C-reactive protein chr1 GO:0097746 Not Cancer Driver No 59 0.263 0 0 0.0 0
CYSLTR1 CYSLTR1 Q9Y271 Cysteinyl leukotriene receptor 1 chrX GO:0097746 Not Cancer Driver No 58 0.172 8 1 0.125 0
DBH DBH P09172 Dopamine beta-hydroxylase chr9 GO:0097746 Not Cancer Driver No 125 0.203 71 17 0.239 3
DOCK4 DOCK4 Q8N1I0 Dedicator of cytokinesis protein 4 chr7 GO:0097746 Not Cancer Driver No 331 0.168 397 80 0.202 0
DOCK5 DOCK5 Q9H7D0 Dedicator of cytokinesis protein 5 chr8 GO:0097746 Not Cancer Driver No 278 0.149 330 45 0.136 0
DRD1 DRD1 P21728 D(1A) dopamine receptor chr5 GO:0097746 Not Cancer Driver No 73 0.164 30 4 0.133 0
DRD5 DRD5 P21918 D(1B) dopamine receptor chr4 GO:0097746 Not Cancer Driver No 172 0.361 29 18 0.621 0
ECE1 ECE1 P42892 Endothelin-converting enzyme 1 chr1 GO:0097746 Not Cancer Driver No 118 0.153 99 26 0.263 1
EDN1 EDN1 P05305 Endothelin-1 chr6 GO:0097746 Not Cancer Driver No 37 0.175 97 20 0.206 3
EDN2 EDN2 P20800 Endothelin-2 chr1 GO:0097746 Not Cancer Driver No 21 0.118 87 13 0.149 0
EDN3_ENST00000371028 EDN3 P14138 Endothelin-3 chr20 GO:0097746 Not Cancer Driver No 69 0.29 140 44 0.314 3
EDNRA EDNRA P25101 Endothelin-1 receptor chr4 GO:0097746 Not Cancer Driver No 62 0.145 21 6 0.286 2
EDNRB_ENST00000334286 EDNRB P24530 Endothelin receptor type B chr13 GO:0097746 Not Cancer Driver No 112 0.253 56 19 0.339 6
EXT1 EXT1 Q16394 Exostosin-1 chr8 GO:0097746 Census Yes 107 0.143 58 7 0.121 12
EXT2_ENST00000533608 EXT2 Q93063 Exostosin-2 chr11 GO:0097746 Census, Compendium Yes 93 0.13 12 1 0.083 9
F2R F2R P25116 Proteinase-activated receptor 1 chr5 GO:0097746 Not Cancer Driver No 73 0.172 19 2 0.105 0
F2RL1 F2RL1 P55085 Proteinase-activated receptor 2 chr5 GO:0097746 Not Cancer Driver No 55 0.139 7 2 0.286 0
FAAH FAAH O00519 Fatty-acid amide hydrolase 1 chr1 GO:0097746 Not Cancer Driver No 63 0.109 50 14 0.28 0
FGA FGA P02671 Fibrinogen alpha chain chr4 GO:0097746 Not Cancer Driver No 245 0.283 522 149 0.285 7
FGB FGB P02675 Fibrinogen beta chain chr4 GO:0097746 Not Cancer Driver No 89 0.181 143 29 0.203 7
FGG FGG P02679 Fibrinogen gamma chain chr4 GO:0097746 Not Cancer Driver No 81 0.179 53 8 0.151 8
FOXC1_ENST00000645831 FOXC1 Q12948 Forkhead box protein C1 chr6 GO:0097746 Not Cancer Driver No 33 0.06 411 24 0.058 32
FOXC2 FOXC2 Q99958 Forkhead box protein C2 chr16 GO:0097746 Not Cancer Driver No 63 0.126 369 33 0.089 1
GCH1_ENST00000622544 GCH1 P30793 GTP cyclohydrolase 1 chr14 GO:0097746 Not Cancer Driver No 20 0.08 99 5 0.051 38
GCLC GCLC P48506 Glutamate--cysteine ligase catalytic subunit chr6 GO:0097746 Not Cancer Driver No 73 0.115 167 18 0.108 3
GCLM GCLM P48507 Glutamate--cysteine ligase regulatory subunit chr1 GO:0097746 Not Cancer Driver No 32 0.117 31 3 0.097 0
GJA5 GJA5 P36382 Gap junction alpha-5 protein chr1 GO:0097746 Not Cancer Driver No 74 0.207 92 21 0.228 5
GPER1 GPER1 Q99527 G-protein coupled estrogen receptor 1 chr7 GO:0097746 Not Cancer Driver No 65 0.173 13 5 0.385 0
GPX1_ENST00000620890 GPX1 P07203 Glutathione peroxidase 1 chr3 GO:0097746 Not Cancer Driver No 38 0.187 12 1 0.083 0
GRIP2_ENST00000621039 GRIP2 Q9C0E4 Glutamate receptor-interacting protein 2 chr3 GO:0097746 Not Cancer Driver No 143 0.137 586 84 0.143 0
HRH1_ENST00000438284 HRH1 P35367 Histamine H1 receptor chr3 GO:0097746 Not Cancer Driver No 96 0.197 122 26 0.213 0
HRH2_ENST00000231683 HRH2 P25021 Histamine H2 receptor chr5 GO:0097746 Not Cancer Driver No 84 0.234 44 6 0.136 0
HTR1A HTR1A P08908 5-hydroxytryptamine receptor 1A chr5 GO:0097746 Not Cancer Driver No 170 0.403 100 49 0.49 0
HTR1B HTR1B P28222 5-hydroxytryptamine receptor 1B chr6 GO:0097746 Not Cancer Driver No 91 0.233 33 15 0.455 0
HTR1D HTR1D P28221 5-hydroxytryptamine receptor 1D chr1 GO:0097746 Not Cancer Driver No 54 0.143 24 1 0.042 0
HTR2A HTR2A P28223 5-hydroxytryptamine receptor 2A chr13 GO:0097746 Not Cancer Driver No 105 0.223 44 8 0.182 0
HTR2B HTR2B P41595 5-hydroxytryptamine receptor 2B chr2 GO:0097746 Not Cancer Driver No 41 0.085 23 2 0.087 0
HTR7 HTR7 P34969 5-hydroxytryptamine receptor 7 chr10 GO:0097746 Not Cancer Driver No 102 0.213 24 1 0.042 0
INS INS P01308 Insulin chr11 GO:0097746 Not Cancer Driver No 15 0.136 5 1 0.2 22
ITGA1 ITGA1 P56199 Integrin alpha-1 chr5 GO:0097746 Not Cancer Driver No 156 0.132 107 13 0.121 0
ITGB1BP1_ENST00000355346 ITGB1BP1 O14713 Integrin beta-1-binding protein 1 chr2 GO:0097746 Not Cancer Driver No 26 0.13 58 11 0.19 0
KCNA5 KCNA5 P22460 Potassium voltage-gated channel subfamily A member 5 chr12 GO:0097746 Not Cancer Driver No 213 0.347 218 53 0.243 0
KCNMB1 KCNMB1 Q16558 Calcium-activated potassium channel subunit beta-1 chr5 GO:0097746 Not Cancer Driver No 49 0.257 0 0 0.0 0
KCNMB2_ENST00000452583 KCNMB2 Q9Y691 Calcium-activated potassium channel subunit beta-2 chr3 GO:0097746 Not Cancer Driver No 61 0.26 0 0 0.0 0
KCNMB4 KCNMB4 Q86W47 Calcium-activated potassium channel subunit beta-4 chr12 GO:0097746 Not Cancer Driver No 41 0.195 0 0 0.0 0
KEL KEL P23276 Kell blood group glycoprotein chr7 GO:0097746 Compendium Yes 232 0.317 117 39 0.333 0
KLF2 KLF2 Q9Y5W3 Krueppel-like factor 2 chr19 GO:0097746 Not Cancer Driver No 13 0.037 280 4 0.014 0
KNG1 KNG1 P01042 Kininogen-1 chr3 GO:0097746 Not Cancer Driver No 130 0.202 294 66 0.224 1
LEP LEP P41159 Leptin chr7 GO:0097746 Not Cancer Driver No 29 0.174 0 0 0.0 2
MKKS MKKS Q9NPJ1 McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin chr20 GO:0097746 Not Cancer Driver No 56 0.098 6 1 0.167 22
MMP2 MMP2 P08253 72 kDa type IV collagenase chr16 GO:0097746 Not Cancer Driver No 123 0.186 29 6 0.207 2
MTNR1B MTNR1B P49286 Melatonin receptor type 1B chr11 GO:0097746 Not Cancer Driver No 104 0.287 8 1 0.125 0
NOS1_ENST00000317775 NOS1 P29475 Nitric oxide synthase, brain chr12 GO:0097746 Not Cancer Driver No 405 0.282 342 99 0.289 0
NOS3 NOS3 P29474 Nitric oxide synthase, endothelial chr7 GO:0097746 Not Cancer Driver No 168 0.14 347 38 0.11 0
NPPA NPPA P01160 Natriuretic peptides A chr1 GO:0097746 Not Cancer Driver No 32 0.212 71 14 0.197 1
NPPB NPPB P16860 Natriuretic peptides B chr1 GO:0097746 Not Cancer Driver No 31 0.231 104 28 0.269 0
NPR1 NPR1 P16066 Atrial natriuretic peptide receptor 1 chr1 GO:0097746 Not Cancer Driver No 141 0.133 78 16 0.205 0
NPR3 NPR3 P17342 Atrial natriuretic peptide receptor 3 chr5 GO:0097746 Not Cancer Driver No 95 0.176 58 8 0.138 0
OXTR OXTR P30559 Oxytocin receptor chr3 GO:0097746 Not Cancer Driver No 46 0.118 18 0 0.0 0
P2RX1 P2RX1 P51575 P2X purinoceptor 1 chr17 GO:0097746 Not Cancer Driver No 59 0.148 14 1 0.071 0
P2RY1 P2RY1 P47900 P2Y purinoceptor 1 chr3 GO:0097746 Not Cancer Driver No 60 0.161 16 1 0.062 0
P2RY2_ENST00000393596 P2RY2 P41231 P2Y purinoceptor 2 chr11 GO:0097746 Not Cancer Driver No 67 0.178 60 13 0.217 0
PER2 PER2 O15055 Period circadian protein homolog 2 chr2 GO:0097746 Not Cancer Driver No 166 0.132 782 101 0.129 1
PIK3C2A PIK3C2A O00443 Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha chr11 GO:0097746 Not Cancer Driver No 187 0.111 350 43 0.123 0
PLA2G6 PLA2G6 O60733 85/88 kDa calcium-independent phospholipase A2 chr22 GO:0097746 Not Cancer Driver No 108 0.134 148 23 0.155 11
PLOD3 PLOD3 O60568 Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 chr7 GO:0097746 Not Cancer Driver No 108 0.146 65 8 0.123 1
PPARD_ENST00000360694 PPARD Q03181 Peroxisome proliferator-activated receptor delta chr6 GO:0097746 Not Cancer Driver No 72 0.163 69 7 0.101 0
PTGS2 PTGS2 P35354 Prostaglandin G/H synthase 2 chr1 GO:0097746 Not Cancer Driver No 105 0.174 30 5 0.167 0
RAP1GDS1_ENST00000408927 RAP1GDS1 P52306 Rap1 GTPase-GDP dissociation stimulator 1 chr4 GO:0097746 Census, Compendium Yes 93 0.153 13 0 0.0 0
RHOA RHOA P61586 Transforming protein RhoA chr3 GO:0097746 Census, Compendium Yes 99 0.513 46 13 0.283 2
ROCK1 ROCK1 Q13464 Rho-associated protein kinase 1 chr18 GO:0097746 Not Cancer Driver No 184 0.136 780 103 0.132 0
ROCK2 ROCK2 O75116 Rho-associated protein kinase 2 chr2 GO:0097746 Not Cancer Driver No 145 0.104 732 81 0.111 0
SCNN1B SCNN1B P51168 Amiloride-sensitive sodium channel subunit beta chr16 GO:0097746 Not Cancer Driver No 90 0.141 62 4 0.065 13
SCPEP1 SCPEP1 Q9HB40 Retinoid-inducible serine carboxypeptidase chr17 GO:0097746 Not Cancer Driver No 46 0.102 1 0 0.0 0
SERPINF2_ENST00000382061 SERPINF2 P08697 Alpha-2-antiplasmin chr17 GO:0097746 Not Cancer Driver No 62 0.126 112 21 0.188 1
SLC6A4_ENST00000401766 SLC6A4 P31645 Sodium-dependent serotonin transporter chr17 GO:0097746 Not Cancer Driver No 101 0.16 73 12 0.164 0
SLC8A1_ENST00000332839 SLC8A1 P32418 Sodium/calcium exchanger 1 chr2 GO:0097746 Not Cancer Driver No 305 0.313 158 48 0.304 0
SMTNL1 SMTNL1 A8MU46 Smoothelin-like protein 1 chr11 GO:0097746 Not Cancer Driver No 80 0.162 372 54 0.145 0
SMTNL2 SMTNL2 Q2TAL5 Smoothelin-like protein 2 chr17 GO:0097746 Not Cancer Driver No 45 0.098 344 33 0.096 0
SNTA1 SNTA1 Q13424 Alpha-1-syntrophin chr20 GO:0097746 Not Cancer Driver No 43 0.085 238 14 0.059 2
SOD2_ENST00000367055 SOD2 P04179 Superoxide dismutase [Mn], mitochondrial chr6 GO:0097746 Not Cancer Driver No 32 0.144 25 5 0.2 0
SOD3 SOD3 P08294 Extracellular superoxide dismutase [Cu-Zn] chr4 GO:0097746 Not Cancer Driver No 22 0.092 123 14 0.114 0
TACR1 TACR1 P25103 Substance-P receptor chr2 GO:0097746 Not Cancer Driver No 69 0.17 28 2 0.071 0
TBXA2R_ENST00000375190 TBXA2R P21731 Thromboxane A2 receptor chr19 GO:0097746 Not Cancer Driver No 47 0.137 17 4 0.235 1
TBXAS1_ENST00000448866 TBXAS1 P24557 Thromboxane-A synthase chr7 GO:0097746 Not Cancer Driver No 116 0.218 44 8 0.182 4
TNF TNF P01375 Tumor necrosis factor chr6 GO:0097746 Not Cancer Driver No 24 0.103 45 3 0.067 0
TRPM4 TRPM4 Q8TD43 Transient receptor potential cation channel subfamily M member 4 chr19 GO:0097746 Not Cancer Driver No 152 0.125 149 18 0.121 12
UCN UCN P55089 Urocortin chr2 GO:0097746 Not Cancer Driver No 7 0.056 61 4 0.066 0
UTS2B_ENST00000427544 UTS2B Q765I0 Urotensin-2B chr3 GO:0097746 Not Cancer Driver No 17 0.143 2 0 0.0 0
UTS2R UTS2R Q9UKP6 Urotensin-2 receptor chr17 GO:0097746 Not Cancer Driver No 45 0.116 74 5 0.068 0
UTS2_ENST00000361696 UTS2 O95399 Urotensin-2 chr1 GO:0097746 Not Cancer Driver No 16 0.129 0 0 0.0 0
VSTM4 VSTM4 Q8IW00 V-set and transmembrane domain-containing protein 4 chr10 GO:0097746 Not Cancer Driver No 91 0.284 47 9 0.191 0
ZDHHC21 ZDHHC21 Q8IVQ6 Palmitoyltransferase ZDHHC21 chr9 GO:0097746 Not Cancer Driver No 34 0.128 0 0 0.0 0