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Total number of protein in "GO:0051492" GO term:  86

Identifier UniProt Gene UniProt Accession UniProt Name Chromosome GO term Database Cancer Driver Number of missense mutations Missense mutation per residues Number of disordered residues Number of mutations in disordered regions Disordered missense mutations per residues Number of OMIM mutation
ABL1_ENST00000318560 ABL1 P00519 Tyrosine-protein kinase ABL1 chr9 GO:0051492 Census, Compendium Yes 139 0.123 604 73 0.121 2
ACTG1_ENST00000575087 ACTG1 P63261 Actin, cytoplasmic 2 chr17 GO:0051492 Not Cancer Driver No 73 0.195 42 10 0.238 16
ALMS1 ALMS1 Q8TCU4 Alstrom syndrome protein 1 chr2 GO:0051492 Not Cancer Driver No 537 0.129 3518 441 0.125 0
APOA1_ENST00000375320 APOA1 P02647 Apolipoprotein A-I chr11 GO:0051492 Not Cancer Driver No 28 0.105 131 8 0.061 3
ARAP1 ARAP1 Q96P48 Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 chr11 GO:0051492 Not Cancer Driver No 152 0.105 401 28 0.07 0
ARHGAP28_ENST00000383472 ARHGAP28 Q9P2N2 Rho GTPase-activating protein 28 chr18 GO:0051492 Not Cancer Driver No 121 0.166 336 45 0.134 0
ARHGAP6 ARHGAP6 O43182 Rho GTPase-activating protein 6 chrX GO:0051492 Not Cancer Driver No 168 0.172 680 118 0.174 0
ARHGEF10L ARHGEF10L Q9HCE6 Rho guanine nucleotide exchange factor 10-like protein chr1 GO:0051492 Census, Compendium Yes 155 0.121 431 47 0.109 0
ARHGEF10_ENST00000398564 ARHGEF10 O15013 Rho guanine nucleotide exchange factor 10 chr8 GO:0051492 Census, Compendium Yes 175 0.128 586 78 0.133 1
ARHGEF15 ARHGEF15 O94989 Rho guanine nucleotide exchange factor 15 chr17 GO:0051492 Not Cancer Driver No 156 0.185 536 97 0.181 0
ARHGEF5 ARHGEF5 Q12774 Rho guanine nucleotide exchange factor 5 chr7 GO:0051492 Not Cancer Driver No 170 0.106 1141 127 0.111 0
ASAP3 ASAP3 Q8TDY4 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 chr1 GO:0051492 Not Cancer Driver No 99 0.11 389 48 0.123 0
BAG4 BAG4 O95429 BAG family molecular chaperone regulator 4 chr8 GO:0051492 Not Cancer Driver No 55 0.12 402 49 0.122 0
BBS4 BBS4 Q96RK4 Bardet-Biedl syndrome 4 protein chr15 GO:0051492 Not Cancer Driver No 58 0.112 110 16 0.145 9
CARMIL1 CARMIL1 Q5VZK9 F-actin-uncapping protein LRRC16A chr6 GO:0051492 Not Cancer Driver No 171 0.125 537 87 0.162 0
CCDC88A_ENST00000642200 CCDC88A Q3V6T2 Girdin chr2 GO:0051492 Not Cancer Driver No 226 0.121 1481 173 0.117 0
CCN2 CCN2 P29279 CCN family member 2 chr6 GO:0051492 Not Cancer Driver No 58 0.166 0 0 0.0 0
CD47 CD47 Q08722 Leukocyte surface antigen CD47 chr3 GO:0051492 Not Cancer Driver No 37 0.115 0 0 0.0 0
CDC42_ENST00000344548 CDC42 P60953 Cell division control protein 42 homolog chr1 GO:0051492 Not Cancer Driver No 39 0.204 23 2 0.087 1
CGNL1 CGNL1 Q0VF96 Cingulin-like protein 1 chr15 GO:0051492 Not Cancer Driver No 191 0.147 1223 182 0.149 0
CLASP1_ENST00000646274 CLASP1 Q7Z460 CLIP-associating protein 1 chr2 GO:0051492 Not Cancer Driver No 163 0.106 642 70 0.109 0
CLASP2 CLASP2 O75122 CLIP-associating protein 2 chr3 GO:0051492 Not Cancer Driver No 158 0.122 676 94 0.139 0
CORO2B CORO2B Q9UQ03 Coronin-2B chr15 GO:0051492 Not Cancer Driver No 85 0.177 37 7 0.189 0
DLC1 DLC1 Q96QB1 Rho GTPase-activating protein 7 chr8 GO:0051492 Not Cancer Driver No 331 0.217 922 237 0.257 0
EPHA1 EPHA1 P21709 Ephrin type-A receptor 1 chr7 GO:0051492 Not Cancer Driver No 147 0.151 211 38 0.18 0
EVL_ENST00000402714 EVL Q9UI08 Ena/VASP-like protein chr14 GO:0051492 Not Cancer Driver No 42 0.101 335 37 0.11 0
F11R F11R Q9Y624 Junctional adhesion molecule A chr1 GO:0051492 Not Cancer Driver No 47 0.157 72 15 0.208 0
FERMT2_ENST00000395631 FERMT2 Q96AC1 Fermitin family homolog 2 chr14 GO:0051492 Not Cancer Driver No 71 0.104 101 10 0.099 0
FHOD1 FHOD1 Q9Y613 FH1/FH2 domain-containing protein 1 chr16 GO:0051492 Not Cancer Driver No 151 0.13 575 82 0.143 0
FRMD7 FRMD7 Q6ZUT3 FERM domain-containing protein 7 chrX GO:0051492 Not Cancer Driver No 147 0.206 256 59 0.23 25
GPR65 GPR65 Q8IYL9 Psychosine receptor chr14 GO:0051492 Not Cancer Driver No 70 0.208 0 0 0.0 0
INPP5K INPP5K Q9BT40 Inositol polyphosphate 5-phosphatase K chr17 GO:0051492 Not Cancer Driver No 42 0.094 34 2 0.059 7
ITGB1BP1_ENST00000355346 ITGB1BP1 O14713 Integrin beta-1-binding protein 1 chr2 GO:0051492 Not Cancer Driver No 26 0.13 58 11 0.19 0
LIMCH1_ENST00000313860 LIMCH1 Q9UPQ0 LIM and calponin homology domains-containing protein 1 chr4 GO:0051492 Not Cancer Driver No 177 0.163 880 140 0.159 0
LIMK1 LIMK1 P53667 LIM domain kinase 1 chr7 GO:0051492 Not Cancer Driver No 110 0.17 170 30 0.176 0
LPAR1_ENST00000358883 LPAR1 Q92633 Lysophosphatidic acid receptor 1 chr9 GO:0051492 Not Cancer Driver No 79 0.217 21 6 0.286 0
MET_ENST00000397752 MET P08581 Hepatocyte growth factor receptor chr7 GO:0051492 Census, Compendium Yes 226 0.163 62 15 0.242 19
MKKS MKKS Q9NPJ1 McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin chr20 GO:0051492 Not Cancer Driver No 56 0.098 6 1 0.167 22
MTOR MTOR P42345 Serine/threonine-protein kinase mTOR chr1 GO:0051492 Census, Compendium Yes 379 0.149 296 37 0.125 18
MYOC MYOC Q99972 Myocilin chr1 GO:0051492 Not Cancer Driver No 92 0.183 196 43 0.219 58
NF2 NF2 P35240 Merlin chr22 GO:0051492 Census, Compendium Yes 69 0.116 252 26 0.103 16
NRP1 NRP1 O14786 Neuropilin-1 chr10 GO:0051492 Compendium Yes 146 0.158 211 31 0.147 0
PAK1_ENST00000356341 PAK1 Q13153 Serine/threonine-protein kinase PAK 1 chr11 GO:0051492 Not Cancer Driver No 57 0.105 299 30 0.1 2
PAK2 PAK2 Q13177 Serine/threonine-protein kinase PAK 2 chr3 GO:0051492 Compendium Yes 89 0.17 242 49 0.202 0
PFN1 PFN1 P07737 Profilin-1 chr17 GO:0051492 Not Cancer Driver No 16 0.114 7 1 0.143 3
PFN2 PFN2 P35080 Profilin-2 chr3 GO:0051492 Not Cancer Driver No 20 0.143 0 0 0.0 0
PHLDB2 PHLDB2 Q86SQ0 Pleckstrin homology-like domain family B member 2 chr3 GO:0051492 Not Cancer Driver No 235 0.188 1030 190 0.184 0
PIK3R1 PIK3R1 P27986 Phosphatidylinositol 3-kinase regulatory subunit alpha chr5 GO:0051492 Census, Compendium Yes 154 0.213 268 61 0.228 2
PPFIA1 PPFIA1 Q13136 Liprin-alpha-1 chr11 GO:0051492 Not Cancer Driver No 164 0.136 865 126 0.146 0
PPM1E PPM1E Q8WY54 Protein phosphatase 1E chr17 GO:0051492 Not Cancer Driver No 114 0.151 384 53 0.138 0
PPM1F PPM1F P49593 Protein phosphatase 1F chr22 GO:0051492 Not Cancer Driver No 53 0.117 242 24 0.099 0
PTGER4 PTGER4 P35408 Prostaglandin E2 receptor EP4 subtype chr5 GO:0051492 Not Cancer Driver No 81 0.166 118 17 0.144 0
PXN_ENST00000228307 PXN P49023 Paxillin chr12 GO:0051492 Not Cancer Driver No 62 0.105 341 24 0.07 0
RAC1_ENST00000348035 RAC1 P63000 Ras-related C3 botulinum toxin substrate 1 chr7 GO:0051492 Census, Compendium Yes 66 0.344 2 1 0.5 6
RAPGEF3 RAPGEF3 O95398 Rap guanine nucleotide exchange factor 3 chr12 GO:0051492 Not Cancer Driver No 97 0.105 197 19 0.096 0
RGCC RGCC Q9H4X1 Regulator of cell cycle RGCC chr13 GO:0051492 Not Cancer Driver No 9 0.066 81 7 0.086 0
RHOA RHOA P61586 Transforming protein RhoA chr3 GO:0051492 Census, Compendium Yes 99 0.513 46 13 0.283 2
RHOC_ENST00000369642 RHOC P08134 Rho-related GTP-binding protein RhoC chr1 GO:0051492 Not Cancer Driver No 30 0.155 53 7 0.132 0
RHPN1 RHPN1 Q8TCX5 Rhophilin-1 chr8 GO:0051492 Not Cancer Driver No 70 0.104 257 27 0.105 0
RHPN2 RHPN2 Q8IUC4 Rhophilin-2 chr19 GO:0051492 Compendium Yes 111 0.162 88 17 0.193 0
ROCK1 ROCK1 Q13464 Rho-associated protein kinase 1 chr18 GO:0051492 Not Cancer Driver No 184 0.136 780 103 0.132 0
ROCK2 ROCK2 O75116 Rho-associated protein kinase 2 chr2 GO:0051492 Not Cancer Driver No 145 0.104 732 81 0.111 0
S100A10 S100A10 P60903 Protein S100-A10 chr1 GO:0051492 Not Cancer Driver No 11 0.113 3 1 0.333 0
S1PR1 S1PR1 P21453 Sphingosine 1-phosphate receptor 1 chr1 GO:0051492 Not Cancer Driver No 86 0.225 29 6 0.207 0
SDC4 SDC4 P31431 Syndecan-4 chr20 GO:0051492 Census, Compendium Yes 34 0.172 110 25 0.227 0
SERPINF2_ENST00000382061 SERPINF2 P08697 Alpha-2-antiplasmin chr17 GO:0051492 Not Cancer Driver No 62 0.126 112 21 0.188 1
SFRP1 SFRP1 Q8N474 Secreted frizzled-related protein 1 chr8 GO:0051492 Not Cancer Driver No 40 0.127 39 7 0.179 0
SLC9A1 SLC9A1 P19634 Sodium/hydrogen exchanger 1 chr1 GO:0051492 Not Cancer Driver No 89 0.109 251 29 0.116 1
SMAD3 SMAD3 P84022 Mothers against decapentaplegic homolog 3 chr15 GO:0051492 Census, Compendium Yes 97 0.228 111 19 0.171 5
SORBS3 SORBS3 O60504 Vinexin chr8 GO:0051492 Not Cancer Driver No 62 0.092 577 56 0.097 0
STMN1_ENST00000357865 STMN1 P16949 Stathmin chr1 GO:0051492 Not Cancer Driver No 15 0.101 149 15 0.101 0
SYNPO2L SYNPO2L Q9H987 Synaptopodin 2-like protein chr10 GO:0051492 Not Cancer Driver No 103 0.105 950 99 0.104 0
TACR1 TACR1 P25103 Substance-P receptor chr2 GO:0051492 Not Cancer Driver No 69 0.17 28 2 0.071 0
TACSTD2 TACSTD2 P09758 Tumor-associated calcium signal transducer 2 chr1 GO:0051492 Not Cancer Driver No 22 0.068 27 1 0.037 0
TESK1_ENST00000336395 TESK1 Q15569 Dual specificity testis-specific protein kinase 1 chr9 GO:0051492 Not Cancer Driver No 63 0.101 339 35 0.103 0
TGFB3 TGFB3 P10600 Transforming growth factor beta-3 proprotein chr14 GO:0051492 Not Cancer Driver No 45 0.109 96 14 0.146 1
TGFBR1_ENST00000374994 TGFBR1 P36897 TGF-beta receptor type-1 chr9 GO:0051492 Not Cancer Driver No 86 0.171 23 3 0.13 15
TJP1_ENST00000346128 TJP1 Q07157 Tight junction protein ZO-1 chr15 GO:0051492 Not Cancer Driver No 198 0.113 1350 151 0.112 0
TMEFF2 TMEFF2 Q9UIK5 Tomoregulin-2 chr2 GO:0051492 Not Cancer Driver No 81 0.217 68 8 0.118 0
TPM1_ENST00000403994 TPM1 P09493 Tropomyosin alpha-1 chain chr15 GO:0051492 Not Cancer Driver No 33 0.116 234 29 0.124 8
TSC1 TSC1 Q92574 Hamartin chr9 GO:0051492 Census, Compendium Yes 135 0.116 732 78 0.107 11
TTC8_ENST00000338104 TTC8 Q8TAM2 Tetratricopeptide repeat protein 8 chr14 GO:0051492 Not Cancer Driver No 74 0.137 98 12 0.122 0
WAS WAS P42768 Wiskott-Aldrich syndrome protein chrX GO:0051492 Census, Compendium Yes 75 0.149 400 55 0.138 30
WASF2 WASF2 Q9Y6W5 Wiskott-Aldrich syndrome protein family member 2 chr1 GO:0051492 Not Cancer Driver No 61 0.122 400 43 0.107 0
WNT11 WNT11 O96014 Protein Wnt-11 chr11 GO:0051492 Not Cancer Driver No 55 0.155 59 4 0.068 0
WNT4 WNT4 P56705 Protein Wnt-4 chr1 GO:0051492 Not Cancer Driver No 30 0.085 39 4 0.103 4