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Total number of protein in "GO:0045862" GO term:  131

Identifier UniProt Gene UniProt Accession UniProt Name Chromosome GO term Database Cancer Driver Number of missense mutations Missense mutation per residues Number of disordered residues Number of mutations in disordered regions Disordered missense mutations per residues Number of OMIM mutation
ADAM8 ADAM8 P78325 Disintegrin and metalloproteinase domain-containing protein 8 chr10 GO:0045862 Not Cancer Driver No 82 0.1 230 13 0.057 0
ADAM9 ADAM9 Q13443 Disintegrin and metalloproteinase domain-containing protein 9 chr8 GO:0045862 Not Cancer Driver No 86 0.105 129 13 0.101 0
ADRA2A ADRA2A P08913 Alpha-2A adrenergic receptor chr10 GO:0045862 Not Cancer Driver No 67 0.144 161 10 0.062 0
AGER_ENST00000375076 AGER Q15109 Advanced glycosylation end product-specific receptor chr6 GO:0045862 Not Cancer Driver No 31 0.077 297 21 0.071 0
ANGPTL8_ENST00000252453 ANGPTL8 Q6UXH0 Angiopoietin-like protein 8 chr19 GO:0045862 Not Cancer Driver No 17 0.086 26 6 0.231 0
ANTXR1 ANTXR1 Q9H6X2 Anthrax toxin receptor 1 chr2 GO:0045862 Not Cancer Driver No 105 0.186 183 44 0.24 0
ANXA2_ENST00000396024 ANXA2 P07355 Annexin A2 chr15 GO:0045862 Not Cancer Driver No 49 0.145 20 4 0.2 0
APAF1 APAF1 O14727 Apoptotic protease-activating factor 1 chr12 GO:0045862 Not Cancer Driver No 127 0.102 17 1 0.059 0
APOE APOE P02649 Apolipoprotein E chr19 GO:0045862 Not Cancer Driver No 25 0.079 124 6 0.048 12
ASPH ASPH Q12797 Aspartyl/asparaginyl beta-hydroxylase chr8 GO:0045862 Not Cancer Driver No 109 0.144 373 53 0.142 1
ASTL ASTL Q6HA08 Astacin-like metalloendopeptidase chr2 GO:0045862 Not Cancer Driver No 101 0.234 179 44 0.246 0
ATXN3 ATXN3 P54252 Ataxin-3 chr14 GO:0045862 Not Cancer Driver No 46 0.127 181 24 0.133 0
AURKAIP1_ENST00000321751 AURKAIP1 Q9NWT8 Aurora kinase A-interacting protein chr1 GO:0045862 Not Cancer Driver No 18 0.09 104 8 0.077 0
BAD_ENST00000309032 BAD Q92934 Bcl2-associated agonist of cell death chr11 GO:0045862 Not Cancer Driver No 14 0.083 163 14 0.086 0
BAG2 BAG2 O95816 BAG family molecular chaperone regulator 2 chr6 GO:0045862 Not Cancer Driver No 17 0.081 112 9 0.08 0
BAG6 BAG6 P46379 Large proline-rich protein BAG6 chr6 GO:0045862 Not Cancer Driver No 98 0.087 861 79 0.092 0
BAK1 BAK1 Q16611 Bcl-2 homologous antagonist/killer chr6 GO:0045862 Not Cancer Driver No 38 0.18 58 9 0.155 0
BAX_ENST00000345358 BAX Q07812 Apoptosis regulator BAX chr19 GO:0045862 Census Yes 30 0.156 39 2 0.051 0
BCAP31_ENST00000345046 BCAP31 P51572 B-cell receptor-associated protein 31 chrX GO:0045862 Not Cancer Driver No 37 0.15 104 14 0.135 0
BOK BOK Q9UMX3 Bcl-2-related ovarian killer protein chr2 GO:0045862 Not Cancer Driver No 7 0.033 0 0 0.0 0
BTRC BTRC Q9Y297 F-box/WD repeat-containing protein 1A chr10 GO:0045862 Not Cancer Driver No 80 0.132 45 4 0.089 0
CAPN3 CAPN3 P20807 Calpain-3 chr15 GO:0045862 Not Cancer Driver No 111 0.135 168 11 0.065 52
CASP8_ENST00000432109 CASP8 Q14790 Caspase-8 chr2 GO:0045862 Census, Compendium Yes 142 0.296 106 12 0.113 1
CASP9 CASP9 P55211 Caspase-9 chr1 GO:0045862 Census Yes 49 0.118 71 7 0.099 0
CAV1 CAV1 Q03135 Caveolin-1 chr7 GO:0045862 Not Cancer Driver No 30 0.169 2 0 0.0 0
CCBE1 CCBE1 Q6UXH8 Collagen and calcium-binding EGF domain-containing protein 1 chr18 GO:0045862 Not Cancer Driver No 92 0.227 227 58 0.256 5
CDC20 CDC20 Q12834 Cell division cycle protein 20 homolog chr1 GO:0045862 Not Cancer Driver No 44 0.088 198 15 0.076 0
CDC20B CDC20B Q86Y33 Cell division cycle protein 20 homolog B chr5 GO:0045862 Not Cancer Driver No 99 0.191 152 24 0.158 0
CIDEB CIDEB Q9UHD4 Cell death activator CIDE-B chr14 GO:0045862 Not Cancer Driver No 19 0.087 23 1 0.043 0
CLDN3 CLDN3 O15551 Claudin-3 chr7 GO:0045862 Not Cancer Driver No 12 0.055 0 0 0.0 0
CLDN4 CLDN4 O14493 Claudin-4 chr7 GO:0045862 Not Cancer Driver No 40 0.191 0 0 0.0 0
CLEC3B CLEC3B P05452 Tetranectin chr3 GO:0045862 Not Cancer Driver No 34 0.168 50 13 0.26 0
CLN6 CLN6 Q9NWW5 Ceroid-lipofuscinosis neuronal protein 6 chr15 GO:0045862 Not Cancer Driver No 28 0.09 13 0 0.0 24
CNTN2 CNTN2 Q02246 Contactin-2 chr1 GO:0045862 Not Cancer Driver No 155 0.149 370 61 0.165 0
CR1_ENST00000367053 CR1 P17927 Complement receptor type 1 chr1 GO:0045862 Compendium Yes 383 0.188 151 42 0.278 0
CYCS_ENST00000409409 CYCS P99999 Cytochrome c chr7 GO:0045862 Not Cancer Driver No 12 0.114 19 3 0.158 1
CYFIP2 CYFIP2 Q96F07 Cytoplasmic FMR1-interacting protein 2 chr5 GO:0045862 Not Cancer Driver No 211 0.165 86 11 0.128 3
DDRGK1 DDRGK1 Q96HY6 DDRGK domain-containing protein 1 chr20 GO:0045862 Not Cancer Driver No 34 0.108 181 23 0.127 0
DIABLO DIABLO Q9NR28 Diablo IAP-binding mitochondrial protein chr12 GO:0045862 Not Cancer Driver No 62 0.259 54 8 0.148 1
EFNA1 EFNA1 P20827 Ephrin-A1 chr1 GO:0045862 Not Cancer Driver No 29 0.141 46 5 0.109 0
EFNA3 EFNA3 P52797 Ephrin-A3 chr1 GO:0045862 Not Cancer Driver No 24 0.101 31 11 0.355 0
ENO1 ENO1 P06733 Alpha-enolase chr1 GO:0045862 Not Cancer Driver No 51 0.118 21 2 0.095 0
EPHA4_ENST00000409938 EPHA4 P54764 Ephrin type-A receptor 4 chr2 GO:0045862 Not Cancer Driver No 182 0.185 140 24 0.171 0
F12 F12 P00748 Coagulation factor XII chr5 GO:0045862 Not Cancer Driver No 53 0.086 104 9 0.087 13
FADD FADD Q13158 FAS-associated death domain protein chr11 GO:0045862 Not Cancer Driver No 26 0.125 45 10 0.222 1
FAS FAS P25445 Tumor necrosis factor receptor superfamily member 6 chr10 GO:0045862 Census, Compendium Yes 55 0.164 62 18 0.29 22
FBXW11 FBXW11 Q9UKB1 F-box/WD repeat-containing protein 11 chr5 GO:0045862 Not Cancer Driver No 75 0.138 20 3 0.15 7
FBXW8 FBXW8 Q8N3Y1 F-box/WD repeat-containing protein 8 chr12 GO:0045862 Not Cancer Driver No 68 0.114 120 4 0.033 0
FGFR4 FGFR4 P22455 Fibroblast growth factor receptor 4 chr5 GO:0045862 Census, Compendium Yes 113 0.141 162 28 0.173 0
FURIN_ENST00000610579 FURIN P09958 Furin chr15 GO:0045862 Not Cancer Driver No 93 0.117 283 35 0.124 0
FZR1 FZR1 Q9UM11 Fizzy-related protein homolog chr19 GO:0045862 Not Cancer Driver No 74 0.149 184 30 0.163 0
GPLD1 GPLD1 P80108 Phosphatidylinositol-glycan-specific phospholipase D chr6 GO:0045862 Not Cancer Driver No 153 0.182 36 9 0.25 0
GRIN2A_ENST00000330684 GRIN2A Q12879 Glutamate receptor ionotropic, NMDA 2A chr16 GO:0045862 Census, Compendium Yes 528 0.361 506 207 0.409 31
GRN GRN P28799 Progranulin chr17 GO:0045862 Not Cancer Driver No 76 0.128 29 6 0.207 1
GSN GSN P06396 Gelsolin chr9 GO:0045862 Not Cancer Driver No 76 0.097 316 28 0.089 2
HDAC2 HDAC2 Q92769 Histone deacetylase 2 chr6 GO:0045862 Not Cancer Driver No 46 0.094 145 14 0.097 0
HERPUD1 HERPUD1 Q15011 Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein chr16 GO:0045862 Census Yes 38 0.097 248 17 0.069 0
HPN_ENST00000392226 HPN P05981 Serine protease hepsin chr19 GO:0045862 Not Cancer Driver No 60 0.144 12 0 0.0 0
HTRA2 HTRA2 O43464 Serine protease HTRA2, mitochondrial chr2 GO:0045862 Compendium Yes 44 0.096 127 9 0.071 2
IFI16_ENST00000295809 IFI16 Q16666 Gamma-interferon-inducible protein 16 chr1 GO:0045862 Not Cancer Driver No 155 0.197 419 90 0.215 0
IFNG IFNG P01579 Interferon gamma chr12 GO:0045862 Not Cancer Driver No 51 0.307 23 6 0.261 0
IL1B IL1B P01584 Interleukin-1 beta chr2 GO:0045862 Not Cancer Driver No 39 0.145 16 3 0.188 0
IST1_ENST00000541571 IST1 P53990 IST1 homolog chr16 GO:0045862 Not Cancer Driver No 31 0.085 185 17 0.092 0
JAK2 JAK2 O60674 Tyrosine-protein kinase JAK2 chr9 GO:0045862 Census, Compendium Yes 136 0.12 59 5 0.085 5
KLKB1 KLKB1 P03952 Plasma kallikrein chr4 GO:0045862 Not Cancer Driver No 117 0.183 24 1 0.042 3
LGALS9 LGALS9 O00182 Galectin-9 chr17 GO:0045862 Not Cancer Driver No 54 0.152 65 16 0.246 0
LGMN_ENST00000334869 LGMN Q99538 Legumain chr14 GO:0045862 Not Cancer Driver No 57 0.132 112 19 0.17 0
LPCAT3 LPCAT3 Q6P1A2 Lysophospholipid acyltransferase 5 chr12 GO:0045862 Not Cancer Driver No 54 0.111 1 0 0.0 0
LYN LYN P07948 Tyrosine-protein kinase Lyn chr8 GO:0045862 Census Yes 95 0.186 84 12 0.143 0
MAPK9 MAPK9 P45984 Mitogen-activated protein kinase 9 chr5 GO:0045862 Not Cancer Driver No 59 0.139 90 8 0.089 0
MBP_ENST00000580402 MBP P02686 Myelin basic protein chr18 GO:0045862 Not Cancer Driver No 52 0.171 304 52 0.171 0
MELTF MELTF P08582 Melanotransferrin chr3 GO:0045862 Not Cancer Driver No 106 0.144 23 6 0.261 0
MKRN2 MKRN2 Q9H000 E3 ubiquitin-protein ligase makorin-2 chr3 GO:0045862 Not Cancer Driver No 45 0.108 145 16 0.11 0
MMP14 MMP14 P50281 Matrix metalloproteinase-14 chr14 GO:0045862 Not Cancer Driver No 64 0.11 118 11 0.093 1
MYH9 MYH9 P35579 Myosin-9 chr22 GO:0045862 Census, Compendium Yes 310 0.158 1120 160 0.143 17
NFE2L2 NFE2L2 Q16236 Nuclear factor erythroid 2-related factor 2 chr2 GO:0045862 Census, Compendium Yes 228 0.377 402 62 0.154 4
NKD2 NKD2 Q969F2 Protein naked cuticle homolog 2 chr5 GO:0045862 Not Cancer Driver No 64 0.142 451 64 0.142 0
NLRC4_ENST00000360906 NLRC4 Q9NPP4 NLR family CARD domain-containing protein 4 chr2 GO:0045862 Not Cancer Driver No 205 0.2 15 2 0.133 3
NLRP6 NLRP6 P59044 NACHT, LRR and PYD domains-containing protein 6 chr11 GO:0045862 Not Cancer Driver No 106 0.119 203 28 0.138 0
NOP53 NOP53 Q9NZM5 Ribosome biogenesis protein NOP53 chr19 GO:0045862 Not Cancer Driver No 59 0.123 391 41 0.105 0
NRDC_ENST00000352171 NRDC O43847 Nardilysin chr1 GO:0045862 Not Cancer Driver No 162 0.141 253 34 0.134 0
OGT OGT O15294 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit chrX GO:0045862 Not Cancer Driver No 156 0.149 89 16 0.18 2
PACSIN3_ENST00000298838 PACSIN3 Q9UKS6 Protein kinase C and casein kinase substrate in neurons protein 3 chr11 GO:0045862 Not Cancer Driver No 52 0.123 290 31 0.107 0
PERP PERP Q96FX8 p53 apoptosis effector related to PMP-22 chr6 GO:0045862 Not Cancer Driver No 28 0.145 0 0 0.0 1
PICALM PICALM Q13492 Phosphatidylinositol-binding clathrin assembly protein chr11 GO:0045862 Census Yes 89 0.137 320 42 0.131 0
PLGRKT PLGRKT Q9HBL7 Plasminogen receptor (KT) chr9 GO:0045862 Not Cancer Driver No 17 0.116 0 0 0.0 0
PLK1 PLK1 P53350 Serine/threonine-protein kinase PLK1 chr16 GO:0045862 Not Cancer Driver No 87 0.144 119 13 0.109 0
PLK3 PLK3 Q9H4B4 Serine/threonine-protein kinase PLK3 chr1 GO:0045862 Not Cancer Driver No 75 0.116 202 15 0.074 0
PRR7_ENST00000502922 PRR7 Q8TB68 Proline-rich protein 7 chr5 GO:0045862 Not Cancer Driver No 10 0.036 199 6 0.03 0
PYCARD PYCARD Q9ULZ3 Apoptosis-associated speck-like protein containing a CARD chr16 GO:0045862 Not Cancer Driver No 16 0.082 39 4 0.103 0
RFPL1 RFPL1 O75677 Ret finger protein-like 1 chr22 GO:0045862 Not Cancer Driver No 73 0.23 28 5 0.179 0
RGMA_ENST00000329082 RGMA Q96B86 Repulsive guidance molecule A chr15 GO:0045862 Not Cancer Driver No 63 0.14 105 13 0.124 0
RHBDD1 RHBDD1 Q8TEB9 Rhomboid-related protein 4 chr2 GO:0045862 Not Cancer Driver No 38 0.121 69 9 0.13 0
RIPK2 RIPK2 O43353 Receptor-interacting serine/threonine-protein kinase 2 chr8 GO:0045862 Not Cancer Driver No 63 0.117 143 20 0.14 0
RNF185 RNF185 Q96GF1 E3 ubiquitin-protein ligase RNF185 chr22 GO:0045862 Not Cancer Driver No 25 0.13 82 15 0.183 0
RNFT1 RNFT1 Q5M7Z0 E3 ubiquitin-protein ligase RNFT1 chr17 GO:0045862 Not Cancer Driver No 37 0.085 117 18 0.154 0
RNFT2_ENST00000392549 RNFT2 Q96EX2 RING finger and transmembrane domain-containing protein 2 chr12 GO:0045862 Not Cancer Driver No 37 0.083 129 10 0.078 0
ROCK2 ROCK2 O75116 Rho-associated protein kinase 2 chr2 GO:0045862 Not Cancer Driver No 145 0.104 732 81 0.111 0
RPS3_ENST00000527446 RPS3 P23396 40S ribosomal protein S3 chr11 GO:0045862 Not Cancer Driver No 22 0.091 48 4 0.083 0
S100A10 S100A10 P60903 Protein S100-A10 chr1 GO:0045862 Not Cancer Driver No 11 0.113 3 1 0.333 0
SART3 SART3 Q15020 Squamous cell carcinoma antigen recognized by T-cells 3 chr12 GO:0045862 Not Cancer Driver No 101 0.105 404 45 0.111 0
SEMG1 SEMG1 P04279 Semenogelin-1 chr20 GO:0045862 Not Cancer Driver No 101 0.219 442 98 0.222 0
SEMG2 SEMG2 Q02383 Semenogelin-2 chr20 GO:0045862 Not Cancer Driver No 147 0.253 561 145 0.258 0
SGTA SGTA O43765 Small glutamine-rich tetratricopeptide repeat-containing protein alpha chr19 GO:0045862 Not Cancer Driver No 38 0.121 159 23 0.145 0
SH3D19_ENST00000409252 SH3D19 Q5HYK7 SH3 domain-containing protein 19 chr4 GO:0045862 Not Cancer Driver No 86 0.109 526 52 0.099 0
SIRT2 SIRT2 Q8IXJ6 NAD-dependent protein deacetylase sirtuin-2 chr19 GO:0045862 Not Cancer Driver No 56 0.144 85 17 0.2 0
SIRT6 SIRT6 Q8N6T7 NAD-dependent protein deacylase sirtuin-6 chr19 GO:0045862 Not Cancer Driver No 33 0.093 164 12 0.073 0
SMAD3 SMAD3 P84022 Mothers against decapentaplegic homolog 3 chr15 GO:0045862 Census, Compendium Yes 97 0.228 111 19 0.171 5
SNX33 SNX33 Q8WV41 Sorting nexin-33 chr15 GO:0045862 Not Cancer Driver No 63 0.11 204 18 0.088 0
SNX9 SNX9 Q9Y5X1 Sorting nexin-9 chr6 GO:0045862 Not Cancer Driver No 71 0.119 231 23 0.1 0
SPON1 SPON1 Q9HCB6 Spondin-1 chr11 GO:0045862 Not Cancer Driver No 120 0.149 191 30 0.157 0
SRC_ENST00000358208 SRC P12931 Proto-oncogene tyrosine-protein kinase Src chr20 GO:0045862 Census Yes 53 0.099 130 11 0.085 1
ST18 ST18 O60284 Suppression of tumorigenicity 18 protein chr8 GO:0045862 Not Cancer Driver No 330 0.315 820 282 0.344 0
STAT3 STAT3 P40763 Signal transducer and activator of transcription 3 chr17 GO:0045862 Census, Compendium Yes 110 0.143 152 15 0.099 19
STUB1 STUB1 Q9UNE7 E3 ubiquitin-protein ligase CHIP chr16 GO:0045862 Not Cancer Driver No 35 0.116 112 14 0.125 12
TANK TANK Q92844 TRAF family member-associated NF-kappa-B activator chr2 GO:0045862 Not Cancer Driver No 42 0.099 302 26 0.086 0
TBC1D10A_ENST00000215790 TBC1D10A Q9BXI6 TBC1 domain family member 10A chr22 GO:0045862 Not Cancer Driver No 72 0.142 209 26 0.124 0
TFAP4 TFAP4 Q01664 Transcription factor AP-4 chr16 GO:0045862 Compendium Yes 61 0.18 285 52 0.182 0
TMEM259 TMEM259 Q4ZIN3 Membralin chr19 GO:0045862 Not Cancer Driver No 40 0.065 188 9 0.048 0
TNF TNF P01375 Tumor necrosis factor chr6 GO:0045862 Not Cancer Driver No 24 0.103 45 3 0.067 0
TNFRSF1B TNFRSF1B P20333 Tumor necrosis factor receptor superfamily member 1B chr1 GO:0045862 Not Cancer Driver No 48 0.104 229 28 0.122 0
TNIP1_ENST00000522226 TNIP1 Q15025 TNFAIP3-interacting protein 1 chr5 GO:0045862 Not Cancer Driver No 85 0.134 625 83 0.133 0
TNP1 TNP1 P09430 Spermatid nuclear transition protein 1 chr2 GO:0045862 Not Cancer Driver No 21 0.382 55 21 0.382 0
TNP2 TNP2 Q05952 Nuclear transition protein 2 chr16 GO:0045862 Not Cancer Driver No 23 0.167 138 23 0.167 0
TRIM32 TRIM32 Q13049 E3 ubiquitin-protein ligase TRIM32 chr9 GO:0045862 Not Cancer Driver No 82 0.126 87 10 0.115 3
UBQLN1 UBQLN1 Q9UMX0 Ubiquilin-1 chr9 GO:0045862 Not Cancer Driver No 64 0.109 543 58 0.107 0
UBQLN2 UBQLN2 Q9UHD9 Ubiquilin-2 chrX GO:0045862 Not Cancer Driver No 82 0.131 581 79 0.136 8
USP13 USP13 Q92995 Ubiquitin carboxyl-terminal hydrolase 13 chr3 GO:0045862 Not Cancer Driver No 121 0.14 224 42 0.188 0
VCP VCP P55072 Transitional endoplasmic reticulum ATPase chr9 GO:0045862 Not Cancer Driver No 88 0.109 186 16 0.086 16
WDR48 WDR48 Q8TAF3 WD repeat-containing protein 48 chr3 GO:0045862 Not Cancer Driver No 61 0.09 125 19 0.152 0
ZC3H12A ZC3H12A Q5D1E8 Endoribonuclease ZC3H12A chr1 GO:0045862 Not Cancer Driver No 90 0.15 396 44 0.111 0