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Total number of protein in "GO:0019221" GO term:  289

Identifier UniProt Gene UniProt Accession UniProt Name Chromosome GO term Database Cancer Driver Number of missense mutations Missense mutation per residues Number of disordered residues Number of mutations in disordered regions Disordered missense mutations per residues Number of OMIM mutation
ACKR1_ENST00000368122 ACKR1 Q16570 Atypical chemokine receptor 1 chr1 GO:0019221 Not Cancer Driver No 94 0.28 0 0 0.0 0
ACKR2 ACKR2 O00590 Atypical chemokine receptor 2 chr3 GO:0019221 Not Cancer Driver No 70 0.182 25 6 0.24 0
ACKR3 ACKR3 P25106 Atypical chemokine receptor 3 chr2 GO:0019221 Census, Compendium Yes 78 0.215 0 0 0.0 1
ACKR4 ACKR4 Q9NPB9 Atypical chemokine receptor 4 chr3 GO:0019221 Not Cancer Driver No 51 0.146 11 1 0.091 0
ACSL1_ENST00000281455 ACSL1 P33121 Long-chain-fatty-acid--CoA ligase 1 chr4 GO:0019221 Not Cancer Driver No 85 0.122 27 1 0.037 0
ADIPOR1 ADIPOR1 Q96A54 Adiponectin receptor protein 1 chr1 GO:0019221 Not Cancer Driver No 63 0.168 69 10 0.145 0
ADIPOR2 ADIPOR2 Q86V24 Adiponectin receptor protein 2 chr12 GO:0019221 Not Cancer Driver No 44 0.114 82 7 0.085 0
AKT1_ENST00000349310 AKT1 P31749 RAC-alpha serine/threonine-protein kinase chr14 GO:0019221 Census, Compendium Yes 108 0.225 158 24 0.152 4
APPL1 APPL1 Q9UKG1 DCC-interacting protein 13-alpha chr3 GO:0019221 Not Cancer Driver No 67 0.094 292 31 0.106 1
APPL2_ENST00000258530 APPL2 Q8NEU8 DCC-interacting protein 13-beta chr12 GO:0019221 Not Cancer Driver No 70 0.105 149 14 0.094 0
BAD_ENST00000309032 BAD Q92934 Bcl2-associated agonist of cell death chr11 GO:0019221 Not Cancer Driver No 14 0.083 163 14 0.086 0
BBS2 BBS2 Q9BXC9 Bardet-Biedl syndrome 2 protein chr16 GO:0019221 Not Cancer Driver No 90 0.125 76 16 0.211 20
BBS4 BBS4 Q96RK4 Bardet-Biedl syndrome 4 protein chr15 GO:0019221 Not Cancer Driver No 58 0.112 110 16 0.145 9
CBL CBL P22681 E3 ubiquitin-protein ligase CBL chr11 GO:0019221 Census, Compendium Yes 115 0.127 512 56 0.109 4
CCL1 CCL1 P22362 C-C motif chemokine 1 chr17 GO:0019221 Not Cancer Driver No 27 0.281 0 0 0.0 0
CCL11 CCL11 P51671 Eotaxin chr17 GO:0019221 Not Cancer Driver No 18 0.186 14 3 0.214 0
CCL13 CCL13 Q99616 C-C motif chemokine 13 chr17 GO:0019221 Not Cancer Driver No 15 0.153 1 0 0.0 0
CCL17_ENST00000616880 CCL17 Q92583 C-C motif chemokine 17 chr16 GO:0019221 Not Cancer Driver No 10 0.106 0 0 0.0 0
CCL19 CCL19 Q99731 C-C motif chemokine 19 chr9 GO:0019221 Not Cancer Driver No 10 0.102 7 0 0.0 0
CCL2 CCL2 P13500 C-C motif chemokine 2 chr17 GO:0019221 Not Cancer Driver No 20 0.202 15 5 0.333 0
CCL20 CCL20 P78556 C-C motif chemokine 20 chr2 GO:0019221 Not Cancer Driver No 16 0.167 0 0 0.0 0
CCL21 CCL21 O00585 C-C motif chemokine 21 chr9 GO:0019221 Not Cancer Driver No 14 0.104 59 6 0.102 0
CCL22 CCL22 O00626 C-C motif chemokine 22 chr16 GO:0019221 Not Cancer Driver No 19 0.204 0 0 0.0 0
CCL24_ENST00000222902 CCL24 O00175 C-C motif chemokine 24 chr7 GO:0019221 Not Cancer Driver No 25 0.21 23 3 0.13 0
CCL25 CCL25 O15444 C-C motif chemokine 25 chr19 GO:0019221 Not Cancer Driver No 20 0.133 26 6 0.231 0
CCL26_ENST00000005180 CCL26 Q9Y258 C-C motif chemokine 26 chr7 GO:0019221 Not Cancer Driver No 9 0.096 0 0 0.0 0
CCL7 CCL7 P80098 C-C motif chemokine 7 chr17 GO:0019221 Not Cancer Driver No 30 0.303 13 3 0.231 0
CCL8 CCL8 P80075 C-C motif chemokine 8 chr17 GO:0019221 Not Cancer Driver No 17 0.172 0 0 0.0 0
CCR1 CCR1 P32246 C-C chemokine receptor type 1 chr3 GO:0019221 Not Cancer Driver No 69 0.194 14 5 0.357 0
CCR10 CCR10 P46092 C-C chemokine receptor type 10 chr17 GO:0019221 Not Cancer Driver No 36 0.099 41 12 0.293 0
CCR2_ENST00000400888 CCR2 P41597 C-C chemokine receptor type 2 chr3 GO:0019221 Not Cancer Driver No 81 0.217 23 1 0.043 0
CCR3_ENST00000357422 CCR3 P51677 C-C chemokine receptor type 3 chr3 GO:0019221 Not Cancer Driver No 84 0.237 0 0 0.0 0
CCR4 CCR4 P51679 C-C chemokine receptor type 4 chr3 GO:0019221 Census Yes 45 0.125 0 0 0.0 0
CCR5 CCR5 P51681 C-C chemokine receptor type 5 chr3 GO:0019221 Not Cancer Driver No 107 0.304 0 0 0.0 0
CCR6_ENST00000349984 CCR6 P51684 C-C chemokine receptor type 6 chr6 GO:0019221 Not Cancer Driver No 56 0.15 13 2 0.154 0
CCR7 CCR7 P32248 C-C chemokine receptor type 7 chr17 GO:0019221 Census, Compendium Yes 50 0.132 0 0 0.0 0
CCR8 CCR8 P51685 C-C chemokine receptor type 8 chr3 GO:0019221 Not Cancer Driver No 57 0.161 3 0 0.0 0
CCR9 CCR9 P51686 C-C chemokine receptor type 9 chr3 GO:0019221 Not Cancer Driver No 60 0.163 0 0 0.0 0
CCRL2_ENST00000399036 CCRL2 O00421 C-C chemokine receptor-like 2 chr3 GO:0019221 Not Cancer Driver No 44 0.128 20 5 0.25 0
CD300LF_ENST00000326165 CD300LF Q8TDQ1 CMRF35-like molecule 1 chr17 GO:0019221 Not Cancer Driver No 36 0.124 88 11 0.125 0
CD4 CD4 P01730 T-cell surface glycoprotein CD4 chr12 GO:0019221 Not Cancer Driver No 69 0.151 56 11 0.196 0
CD44 CD44 P16070 CD44 antigen chr11 GO:0019221 Not Cancer Driver No 75 0.101 542 60 0.111 0
CD74 CD74 P04233 HLA class II histocompatibility antigen gamma chain chr5 GO:0019221 Census Yes 31 0.105 185 20 0.108 0
CEACAM1 CEACAM1 P13688 Carcinoembryonic antigen-related cell adhesion molecule 1 chr19 GO:0019221 Not Cancer Driver No 64 0.122 241 25 0.104 0
CEBPA CEBPA P49715 CCAAT/enhancer-binding protein alpha chr19 GO:0019221 Census, Compendium Yes 12 0.034 342 12 0.035 1
CIB1_ENST00000328649 CIB1 Q99828 Calcium and integrin-binding protein 1 chr15 GO:0019221 Not Cancer Driver No 24 0.126 6 1 0.167 0
CLCF1 CLCF1 Q9UBD9 Cardiotrophin-like cytokine factor 1 chr11 GO:0019221 Not Cancer Driver No 22 0.098 42 4 0.095 1
CLDN18 CLDN18 P56856 Claudin-18 chr3 GO:0019221 Not Cancer Driver No 44 0.169 21 5 0.238 0
CMKLR1 CMKLR1 Q99788 Chemerin-like receptor 1 chr12 GO:0019221 Not Cancer Driver No 107 0.287 24 13 0.542 0
CNOT9_ENST00000273064 CNOT9 Q92600 CCR4-NOT transcription complex subunit 9 chr2 GO:0019221 Compendium Yes 42 0.14 30 0 0.0 0
CNTF CNTF P26441 Ciliary neurotrophic factor chr11 GO:0019221 Not Cancer Driver No 41 0.205 34 5 0.147 0
CNTFR_ENST00000351266 CNTFR P26992 Ciliary neurotrophic factor receptor subunit alpha chr9 GO:0019221 Not Cancer Driver No 50 0.134 92 8 0.087 0
CRLF1 CRLF1 O75462 Cytokine receptor-like factor 1 chr19 GO:0019221 Not Cancer Driver No 51 0.121 101 7 0.069 14
CRLF2_ENST00000381566 CRLF2 Q9HC73 Cytokine receptor-like factor 2 chrX GO:0019221 Census Yes 54 0.146 62 3 0.048 0
CSF1R CSF1R P07333 Macrophage colony-stimulating factor 1 receptor chr5 GO:0019221 Census Yes 133 0.137 124 17 0.137 20
CSF1_ENST00000369802 CSF1 P09603 Macrophage colony-stimulating factor 1 chr1 GO:0019221 Not Cancer Driver No 69 0.125 339 46 0.136 0
CSF2 CSF2 P04141 Granulocyte-macrophage colony-stimulating factor chr5 GO:0019221 Not Cancer Driver No 11 0.076 34 3 0.088 0
CSF2RA_ENST00000381524 CSF2RA P15509 Granulocyte-macrophage colony-stimulating factor receptor subunit alpha chrX GO:0019221 Not Cancer Driver No 148 0.37 12 2 0.167 1
CSF2RB CSF2RB P32927 Cytokine receptor common subunit beta chr22 GO:0019221 Not Cancer Driver No 204 0.227 541 120 0.222 0
CSF3 CSF3 P09919 Granulocyte colony-stimulating factor chr17 GO:0019221 Not Cancer Driver No 20 0.097 7 0 0.0 0
CSF3R_ENST00000361632 CSF3R Q99062 Granulocyte colony-stimulating factor receptor chr1 GO:0019221 Census, Compendium Yes 131 0.157 209 34 0.163 2
CSNK2B_ENST00000375866 CSNK2B P67870 Casein kinase II subunit beta chr6 GO:0019221 Not Cancer Driver No 20 0.093 19 0 0.0 4
CTR9 CTR9 Q6PD62 RNA polymerase-associated protein CTR9 homolog chr11 GO:0019221 Not Cancer Driver No 164 0.14 385 48 0.125 0
CTSG CTSG P08311 Cathepsin G chr14 GO:0019221 Not Cancer Driver No 65 0.255 80 29 0.362 0
CX3CL1 CX3CL1 P78423 Fractalkine chr16 GO:0019221 Not Cancer Driver No 66 0.166 259 44 0.17 0
CX3CR1_ENST00000542107 CX3CR1 P49238 CX3C chemokine receptor 1 chr3 GO:0019221 Not Cancer Driver No 80 0.225 0 0 0.0 0
CXCL1 CXCL1 P09341 Growth-regulated alpha protein chr4 GO:0019221 Not Cancer Driver No 20 0.187 18 4 0.222 0
CXCL10 CXCL10 P02778 C-X-C motif chemokine 10 chr4 GO:0019221 Not Cancer Driver No 19 0.194 12 4 0.333 0
CXCL11 CXCL11 O14625 C-X-C motif chemokine 11 chr4 GO:0019221 Not Cancer Driver No 13 0.138 0 0 0.0 0
CXCL12_ENST00000374429 CXCL12 P48061 Stromal cell-derived factor 1 chr10 GO:0019221 Not Cancer Driver No 16 0.172 0 0 0.0 0
CXCL13 CXCL13 O43927 C-X-C motif chemokine 13 chr4 GO:0019221 Not Cancer Driver No 11 0.101 0 0 0.0 0
CXCL2 CXCL2 P19875 C-X-C motif chemokine 2 chr4 GO:0019221 Not Cancer Driver No 11 0.103 15 5 0.333 0
CXCL3 CXCL3 P19876 C-X-C motif chemokine 3 chr4 GO:0019221 Not Cancer Driver No 11 0.103 8 0 0.0 0
CXCL5 CXCL5 P42830 C-X-C motif chemokine 5 chr4 GO:0019221 Not Cancer Driver No 25 0.219 1 0 0.0 0
CXCL6 CXCL6 P80162 C-X-C motif chemokine 6 chr4 GO:0019221 Not Cancer Driver No 17 0.149 9 1 0.111 0
CXCL8 CXCL8 P10145 Interleukin-8 chr4 GO:0019221 Not Cancer Driver No 17 0.172 0 0 0.0 0
CXCL9 CXCL9 Q07325 C-X-C motif chemokine 9 chr4 GO:0019221 Not Cancer Driver No 32 0.256 38 16 0.421 0
CXCR1 CXCR1 P25024 C-X-C chemokine receptor type 1 chr2 GO:0019221 Not Cancer Driver No 71 0.203 0 0 0.0 0
CXCR2 CXCR2 P25025 C-X-C chemokine receptor type 2 chr2 GO:0019221 Not Cancer Driver No 87 0.242 8 0 0.0 0
CXCR3_ENST00000373693 CXCR3 P49682 C-X-C chemokine receptor type 3 chrX GO:0019221 Not Cancer Driver No 58 0.158 15 0 0.0 0
CXCR4_ENST00000241393 CXCR4 P61073 C-X-C chemokine receptor type 4 chr2 GO:0019221 Census, Compendium Yes 62 0.176 5 1 0.2 0
CXCR5 CXCR5 P32302 C-X-C chemokine receptor type 5 chr11 GO:0019221 Not Cancer Driver No 41 0.11 0 0 0.0 0
CXCR6_ENST00000304552 CXCR6 O00574 C-X-C chemokine receptor type 6 chr3 GO:0019221 Not Cancer Driver No 40 0.117 0 0 0.0 0
DOK1 DOK1 Q99704 Docking protein 1 chr2 GO:0019221 Not Cancer Driver No 50 0.104 294 31 0.105 0
DUOX1 DUOX1 Q9NRD9 Dual oxidase 1 chr15 GO:0019221 Not Cancer Driver No 193 0.124 158 17 0.108 0
DUOX2 DUOX2 Q9NRD8 Dual oxidase 2 chr15 GO:0019221 Not Cancer Driver No 245 0.158 182 25 0.137 3
EBI3 EBI3 Q14213 Interleukin-27 subunit beta chr19 GO:0019221 Not Cancer Driver No 32 0.14 10 1 0.1 0
EDN2 EDN2 P20800 Endothelin-2 chr1 GO:0019221 Not Cancer Driver No 21 0.118 87 13 0.149 0
EGR1 EGR1 P18146 Early growth response protein 1 chr5 GO:0019221 Not Cancer Driver No 78 0.144 501 72 0.144 0
EPO EPO P01588 Erythropoietin chr7 GO:0019221 Not Cancer Driver No 27 0.14 9 1 0.111 1
EPOR EPOR P19235 Erythropoietin receptor chr19 GO:0019221 Not Cancer Driver No 41 0.081 120 11 0.092 1
EREG EREG O14944 Proepiregulin chr4 GO:0019221 Not Cancer Driver No 26 0.154 10 3 0.3 0
EXT1 EXT1 Q16394 Exostosin-1 chr8 GO:0019221 Census Yes 107 0.143 58 7 0.121 12
F3 F3 P13726 Tissue factor chr1 GO:0019221 Not Cancer Driver No 28 0.095 61 7 0.115 0
FCER1G FCER1G P30273 High affinity immunoglobulin epsilon receptor subunit gamma chr1 GO:0019221 Not Cancer Driver No 10 0.116 13 2 0.154 0
FER FER P16591 Tyrosine-protein kinase Fer chr5 GO:0019221 Not Cancer Driver No 114 0.139 145 21 0.145 0
FLT3 FLT3 P36888 Receptor-type tyrosine-protein kinase FLT3 chr13 GO:0019221 Census, Compendium Yes 200 0.201 64 27 0.422 0
FOXC1_ENST00000645831 FOXC1 Q12948 Forkhead box protein C1 chr6 GO:0019221 Not Cancer Driver No 33 0.06 411 24 0.058 32
FZD4 FZD4 Q9ULV1 Frizzled-4 chr11 GO:0019221 Not Cancer Driver No 57 0.106 33 5 0.152 19
GHR_ENST00000612382 GHR P10912 Growth hormone receptor chr5 GO:0019221 Not Cancer Driver No 173 0.271 229 66 0.288 19
GPR17 GPR17 Q13304 Uracil nucleotide/cysteinyl leukotriene receptor chr2 GO:0019221 Not Cancer Driver No 57 0.155 16 4 0.25 0
GPR35_ENST00000403859 GPR35 Q9HC97 G-protein coupled receptor 35 chr2 GO:0019221 Not Cancer Driver No 57 0.184 0 0 0.0 0
GREM2 GREM2 Q9H772 Gremlin-2 chr1 GO:0019221 Not Cancer Driver No 54 0.321 22 9 0.409 3
HCK_ENST00000534862 HCK P08631 Tyrosine-protein kinase HCK chr20 GO:0019221 Not Cancer Driver No 112 0.213 124 25 0.202 0
IFNA10 IFNA10 P01566 Interferon alpha-10 chr9 GO:0019221 Not Cancer Driver No 40 0.212 1 0 0.0 0
IFNA13_ENST00000449498 IFNA13 P01562 Interferon alpha-1/13 chr9 GO:0019221 Not Cancer Driver No 39 0.206 2 0 0.0 0
IFNA14 IFNA14 P01570 Interferon alpha-14 chr9 GO:0019221 Not Cancer Driver No 39 0.206 1 1 1.0 0
IFNA16 IFNA16 P05015 Interferon alpha-16 chr9 GO:0019221 Not Cancer Driver No 61 0.323 1 0 0.0 0
IFNA17 IFNA17 P01571 Interferon alpha-17 chr9 GO:0019221 Not Cancer Driver No 37 0.196 0 0 0.0 0
IFNA2 IFNA2 P01563 Interferon alpha-2 chr9 GO:0019221 Not Cancer Driver No 38 0.202 2 0 0.0 0
IFNA21 IFNA21 P01568 Interferon alpha-21 chr9 GO:0019221 Not Cancer Driver No 34 0.18 0 0 0.0 0
IFNA4 IFNA4 P05014 Interferon alpha-4 chr9 GO:0019221 Not Cancer Driver No 39 0.206 1 0 0.0 0
IFNA5 IFNA5 P01569 Interferon alpha-5 chr9 GO:0019221 Not Cancer Driver No 36 0.19 1 0 0.0 0
IFNA6 IFNA6 P05013 Interferon alpha-6 chr9 GO:0019221 Not Cancer Driver No 28 0.148 4 0 0.0 0
IFNA7 IFNA7 P01567 Interferon alpha-7 chr9 GO:0019221 Not Cancer Driver No 43 0.228 1 1 1.0 0
IFNA8 IFNA8 P32881 Interferon alpha-8 chr9 GO:0019221 Not Cancer Driver No 43 0.228 0 0 0.0 0
IFNAR1 IFNAR1 P17181 Interferon alpha/beta receptor 1 chr21 GO:0019221 Compendium Yes 55 0.099 50 6 0.12 0
IFNAR2 IFNAR2 P48551 Interferon alpha/beta receptor 2 chr21 GO:0019221 Not Cancer Driver No 58 0.113 199 24 0.121 0
IFNB1 IFNB1 P01574 Interferon beta chr9 GO:0019221 Not Cancer Driver No 46 0.246 0 0 0.0 0
IFNE IFNE Q86WN2 Interferon epsilon chr9 GO:0019221 Not Cancer Driver No 30 0.144 17 4 0.235 0
IFNG IFNG P01579 Interferon gamma chr12 GO:0019221 Not Cancer Driver No 51 0.307 23 6 0.261 0
IFNGR1 IFNGR1 P15260 Interferon gamma receptor 1 chr6 GO:0019221 Compendium Yes 55 0.112 175 22 0.126 10
IFNGR2_ENST00000290219 IFNGR2 P38484 Interferon gamma receptor 2 chr21 GO:0019221 Not Cancer Driver No 36 0.107 18 2 0.111 5
IFNK IFNK Q9P0W0 Interferon kappa chr9 GO:0019221 Not Cancer Driver No 17 0.082 23 0 0.0 0
IFNLR1 IFNLR1 Q8IU57 Interferon lambda receptor 1 chr1 GO:0019221 Not Cancer Driver No 57 0.11 256 33 0.129 0
IFNW1 IFNW1 P05000 Interferon omega-1 chr9 GO:0019221 Not Cancer Driver No 32 0.164 10 3 0.3 0
IKBKB IKBKB O14920 Inhibitor of nuclear factor kappa-B kinase subunit beta chr8 GO:0019221 Census, Compendium Yes 106 0.14 211 31 0.147 1
IKBKE IKBKE Q14164 Inhibitor of nuclear factor kappa-B kinase subunit epsilon chr1 GO:0019221 Not Cancer Driver No 108 0.151 76 13 0.171 0
IL10RA IL10RA Q13651 Interleukin-10 receptor subunit alpha chr11 GO:0019221 Not Cancer Driver No 77 0.133 220 26 0.118 7
IL10RB IL10RB Q08334 Interleukin-10 receptor subunit beta chr21 GO:0019221 Not Cancer Driver No 52 0.16 39 5 0.128 0
IL11RA_ENST00000441545 IL11RA Q14626 Interleukin-11 receptor subunit alpha chr9 GO:0019221 Not Cancer Driver No 48 0.114 153 11 0.072 3
IL12B IL12B P29460 Interleukin-12 subunit beta chr5 GO:0019221 Not Cancer Driver No 48 0.146 42 2 0.048 0
IL12RB1_ENST00000593993 IL12RB1 P42701 Interleukin-12 receptor subunit beta-1 chr19 GO:0019221 Not Cancer Driver No 108 0.163 207 38 0.184 1
IL12RB2 IL12RB2 Q99665 Interleukin-12 receptor subunit beta-2 chr1 GO:0019221 Not Cancer Driver No 129 0.15 195 31 0.159 0
IL13RA1 IL13RA1 P78552 Interleukin-13 receptor subunit alpha-1 chrX GO:0019221 Not Cancer Driver No 58 0.136 33 7 0.212 0
IL13RA2_ENST00000243213 IL13RA2 Q14627 Interleukin-13 receptor subunit alpha-2 chrX GO:0019221 Not Cancer Driver No 69 0.182 0 0 0.0 0
IL15RA_ENST00000379977 IL15RA Q13261 Interleukin-15 receptor subunit alpha chr10 GO:0019221 Not Cancer Driver No 40 0.15 173 32 0.185 0
IL15_ENST00000320650 IL15 P40933 Interleukin-15 chr4 GO:0019221 Not Cancer Driver No 25 0.154 6 1 0.167 0
IL17A IL17A Q16552 Interleukin-17A chr6 GO:0019221 Not Cancer Driver No 52 0.335 56 21 0.375 0
IL17F IL17F Q96PD4 Interleukin-17F chr6 GO:0019221 Not Cancer Driver No 42 0.258 34 11 0.324 1
IL17RA IL17RA Q96F46 Interleukin-17 receptor A chr22 GO:0019221 Not Cancer Driver No 92 0.106 301 20 0.066 0
IL17RB IL17RB Q9NRM6 Interleukin-17 receptor B chr3 GO:0019221 Not Cancer Driver No 50 0.1 30 3 0.1 0
IL17RC IL17RC Q8NAC3 Interleukin-17 receptor C chr3 GO:0019221 Not Cancer Driver No 84 0.106 129 10 0.078 0
IL17RD IL17RD Q8NFM7 Interleukin-17 receptor D chr3 GO:0019221 Not Cancer Driver No 98 0.133 177 17 0.096 7
IL17RE IL17RE Q8NFR9 Interleukin-17 receptor E chr3 GO:0019221 Not Cancer Driver No 61 0.091 55 10 0.182 0
IL17REL_ENST00000341280 IL17REL Q6ZVW7 Putative interleukin-17 receptor E-like chr22 GO:0019221 Not Cancer Driver No 35 0.104 28 0 0.0 0
IL18 IL18 Q14116 Interleukin-18 chr11 GO:0019221 Not Cancer Driver No 19 0.098 16 3 0.188 0
IL18R1_ENST00000233957 IL18R1 Q13478 Interleukin-18 receptor 1 chr2 GO:0019221 Not Cancer Driver No 104 0.192 18 3 0.167 0
IL18RAP IL18RAP O95256 Interleukin-18 receptor accessory protein chr2 GO:0019221 Not Cancer Driver No 145 0.242 20 9 0.45 0
IL1A IL1A P01583 Interleukin-1 alpha chr2 GO:0019221 Not Cancer Driver No 30 0.111 35 6 0.171 0
IL1B IL1B P01584 Interleukin-1 beta chr2 GO:0019221 Not Cancer Driver No 39 0.145 16 3 0.188 0
IL1F10_ENST00000341010 IL1F10 Q8WWZ1 Interleukin-1 family member 10 chr2 GO:0019221 Not Cancer Driver No 30 0.197 10 1 0.1 0
IL1R1 IL1R1 P14778 Interleukin-1 receptor type 1 chr2 GO:0019221 Not Cancer Driver No 77 0.135 59 8 0.136 0
IL1R2_ENST00000393414 IL1R2 P27930 Interleukin-1 receptor type 2 chr2 GO:0019221 Not Cancer Driver No 75 0.188 32 10 0.312 0
IL1RAPL2 IL1RAPL2 Q9NP60 X-linked interleukin-1 receptor accessory protein-like 2 chrX GO:0019221 Not Cancer Driver No 174 0.254 44 14 0.318 0
IL1RAP_ENST00000447382 IL1RAP Q9NPH3 Interleukin-1 receptor accessory protein chr3 GO:0019221 Not Cancer Driver No 79 0.139 50 11 0.22 0
IL1RL1 IL1RL1 Q01638 Interleukin-1 receptor-like 1 chr2 GO:0019221 Not Cancer Driver No 119 0.214 24 8 0.333 0
IL1RL2 IL1RL2 Q9HB29 Interleukin-1 receptor-like 2 chr2 GO:0019221 Not Cancer Driver No 114 0.198 11 4 0.364 0
IL20RA IL20RA Q9UHF4 Interleukin-20 receptor subunit alpha chr6 GO:0019221 Not Cancer Driver No 72 0.13 231 29 0.126 0
IL20RB IL20RB Q6UXL0 Interleukin-20 receptor subunit beta chr3 GO:0019221 Not Cancer Driver No 40 0.129 0 0 0.0 0
IL21R_ENST00000395754 IL21R Q9HBE5 Interleukin-21 receptor chr16 GO:0019221 Census Yes 133 0.247 183 47 0.257 1
IL22RA1 IL22RA1 Q8N6P7 Interleukin-22 receptor subunit alpha-1 chr1 GO:0019221 Not Cancer Driver No 66 0.115 297 37 0.125 0
IL22RA2 IL22RA2 Q969J5 Interleukin-22 receptor subunit alpha-2 chr6 GO:0019221 Not Cancer Driver No 35 0.133 14 3 0.214 0
IL23R IL23R Q5VWK5 Interleukin-23 receptor chr1 GO:0019221 Not Cancer Driver No 70 0.111 117 19 0.162 0
IL27RA IL27RA Q6UWB1 Interleukin-27 receptor subunit alpha chr19 GO:0019221 Not Cancer Driver No 91 0.143 167 23 0.138 0
IL2RA IL2RA P01589 Interleukin-2 receptor subunit alpha chr10 GO:0019221 Not Cancer Driver No 51 0.188 131 29 0.221 2
IL2RB IL2RB P14784 Interleukin-2 receptor subunit beta chr22 GO:0019221 Not Cancer Driver No 81 0.147 182 33 0.181 1
IL2RG IL2RG P31785 Cytokine receptor common subunit gamma chrX GO:0019221 Not Cancer Driver No 56 0.152 32 6 0.188 33
IL31RA_ENST00000297015 IL31RA Q8NI17 Interleukin-31 receptor subunit alpha chr5 GO:0019221 Not Cancer Driver No 117 0.16 163 30 0.184 1
IL33 IL33 O95760 Interleukin-33 chr9 GO:0019221 Not Cancer Driver No 47 0.174 47 8 0.17 0
IL34 IL34 Q6ZMJ4 Interleukin-34 chr16 GO:0019221 Not Cancer Driver No 22 0.091 42 6 0.143 0
IL36A IL36A Q9UHA7 Interleukin-36 alpha chr2 GO:0019221 Not Cancer Driver No 44 0.278 13 3 0.231 0
IL36B IL36B Q9NZH7 Interleukin-36 beta chr2 GO:0019221 Not Cancer Driver No 53 0.323 32 8 0.25 0
IL36G IL36G Q9NZH8 Interleukin-36 gamma chr2 GO:0019221 Not Cancer Driver No 35 0.207 23 5 0.217 0
IL37 IL37 Q9NZH6 Interleukin-37 chr2 GO:0019221 Not Cancer Driver No 56 0.257 71 13 0.183 1
IL3RA IL3RA P26951 Interleukin-3 receptor subunit alpha chrX GO:0019221 Not Cancer Driver No 89 0.235 9 2 0.222 0
IL4R_ENST00000543915 IL4R P24394 Interleukin-4 receptor subunit alpha chr16 GO:0019221 Not Cancer Driver No 133 0.161 420 64 0.152 0
IL5 IL5 P05113 Interleukin-5 chr5 GO:0019221 Not Cancer Driver No 13 0.097 0 0 0.0 0
IL5RA_ENST00000256452 IL5RA Q01344 Interleukin-5 receptor subunit alpha chr3 GO:0019221 Not Cancer Driver No 92 0.219 23 5 0.217 0
IL6 IL6 P05231 Interleukin-6 chr7 GO:0019221 Not Cancer Driver No 35 0.165 58 7 0.121 0
IL6R IL6R P08887 Interleukin-6 receptor subunit alpha chr1 GO:0019221 Not Cancer Driver No 55 0.118 165 23 0.139 1
IL6ST_ENST00000336909 IL6ST P40189 Interleukin-6 receptor subunit beta chr5 GO:0019221 Census, Compendium Yes 102 0.111 315 40 0.127 2
IL7 IL7 P13232 Interleukin-7 chr8 GO:0019221 Not Cancer Driver No 29 0.164 19 4 0.211 0
IL7R IL7R P16871 Interleukin-7 receptor subunit alpha chr5 GO:0019221 Census, Compendium Yes 177 0.386 88 48 0.545 1
IL9R IL9R Q01113 Interleukin-9 receptor chrX GO:0019221 Not Cancer Driver No 96 0.184 78 18 0.231 0
IRAK1 IRAK1 P51617 Interleukin-1 receptor-associated kinase 1 chrX GO:0019221 Compendium Yes 71 0.1 337 39 0.116 0
IRAK2 IRAK2 O43187 Interleukin-1 receptor-associated kinase-like 2 chr3 GO:0019221 Not Cancer Driver No 84 0.134 202 32 0.158 0
IRAK3 IRAK3 Q9Y616 Interleukin-1 receptor-associated kinase 3 chr12 GO:0019221 Not Cancer Driver No 103 0.173 79 14 0.177 0
IRAK4_ENST00000551736 IRAK4 Q9NWZ3 Interleukin-1 receptor-associated kinase 4 chr12 GO:0019221 Not Cancer Driver No 68 0.148 116 20 0.172 2
IRF1 IRF1 P10914 Interferon regulatory factor 1 chr5 GO:0019221 Compendium Yes 49 0.151 228 31 0.136 2
IRF5_ENST00000402030 IRF5 Q13568 Interferon regulatory factor 5 chr7 GO:0019221 Not Cancer Driver No 93 0.187 237 64 0.27 0
JAGN1 JAGN1 Q8N5M9 Protein jagunal homolog 1 chr3 GO:0019221 Not Cancer Driver No 21 0.115 12 2 0.167 5
JAK1 JAK1 P23458 Tyrosine-protein kinase JAK1 chr1 GO:0019221 Census, Compendium Yes 147 0.127 120 7 0.058 2
JAK2 JAK2 O60674 Tyrosine-protein kinase JAK2 chr9 GO:0019221 Census, Compendium Yes 136 0.12 59 5 0.085 5
JAK3 JAK3 P52333 Tyrosine-protein kinase JAK3 chr19 GO:0019221 Census, Compendium Yes 167 0.149 63 10 0.159 7
KIT KIT P10721 Mast/stem cell growth factor receptor Kit chr4 GO:0019221 Census, Compendium Yes 226 0.232 83 33 0.398 21
LEP LEP P41159 Leptin chr7 GO:0019221 Not Cancer Driver No 29 0.174 0 0 0.0 2
LEPR LEPR P48357 Leptin receptor chr1 GO:0019221 Not Cancer Driver No 243 0.209 57 11 0.193 0
LIFR_ENST00000453190 LIFR P42702 Leukemia inhibitory factor receptor chr5 GO:0019221 Census, Compendium Yes 247 0.225 259 56 0.216 1
LILRA1 LILRA1 O75019 Leukocyte immunoglobulin-like receptor subfamily A member 1 chr19 GO:0019221 Not Cancer Driver No 162 0.331 78 26 0.333 0
LILRA2 LILRA2 Q8N149 Leukocyte immunoglobulin-like receptor subfamily A member 2 chr19 GO:0019221 Not Cancer Driver No 163 0.337 137 44 0.321 0
LILRA4 LILRA4 P59901 Leukocyte immunoglobulin-like receptor subfamily A member 4 chr19 GO:0019221 Not Cancer Driver No 124 0.248 109 26 0.239 0
LILRA5 LILRA5 A6NI73 Leukocyte immunoglobulin-like receptor subfamily A member 5 chr19 GO:0019221 Not Cancer Driver No 79 0.264 98 19 0.194 0
LILRA6 LILRA6 Q6PI73 Leukocyte immunoglobulin-like receptor subfamily A member 6 chr19 GO:0019221 Not Cancer Driver No 134 0.279 162 41 0.253 0
LILRB1_ENST00000396331 LILRB1 Q8NHL6 Leukocyte immunoglobulin-like receptor subfamily B member 1 chr19 GO:0019221 Not Cancer Driver No 203 0.312 291 97 0.333 0
LILRB2_ENST00000314446 LILRB2 Q8N423 Leukocyte immunoglobulin-like receptor subfamily B member 2 chr19 GO:0019221 Not Cancer Driver No 148 0.248 235 50 0.213 0
LILRB4 LILRB4 Q8NHJ6 Leukocyte immunoglobulin-like receptor subfamily B member 4 chr19 GO:0019221 Not Cancer Driver No 162 0.362 277 115 0.415 0
LILRB5_ENST00000316219 LILRB5 O75023 Leukocyte immunoglobulin-like receptor subfamily B member 5 chr19 GO:0019221 Not Cancer Driver No 157 0.266 202 73 0.361 0
LRP8 LRP8 Q14114 Low-density lipoprotein receptor-related protein 8 chr1 GO:0019221 Not Cancer Driver No 94 0.098 190 24 0.126 0
MAP3K7 MAP3K7 O43318 Mitogen-activated protein kinase kinase kinase 7 chr6 GO:0019221 Not Cancer Driver No 104 0.172 333 66 0.198 6
MAPK3 MAPK3 P27361 Mitogen-activated protein kinase 3 chr16 GO:0019221 Not Cancer Driver No 38 0.1 49 5 0.102 0
MKKS MKKS Q9NPJ1 McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin chr20 GO:0019221 Not Cancer Driver No 56 0.098 6 1 0.167 22
MPL MPL P40238 Thrombopoietin receptor chr1 GO:0019221 Census Yes 77 0.121 129 19 0.147 14
MST1R MST1R Q04912 Macrophage-stimulating protein receptor chr3 GO:0019221 Not Cancer Driver No 178 0.127 182 27 0.148 1
MT3 MT3 P25713 Metallothionein-3 chr16 GO:0019221 Not Cancer Driver No 7 0.103 0 0 0.0 0
MX1_ENST00000398598 MX1 P20591 Interferon-induced GTP-binding protein Mx1 chr21 GO:0019221 Not Cancer Driver No 88 0.133 74 10 0.135 0
MYD88_ENST00000396334 MYD88 Q99836 Myeloid differentiation primary response protein MyD88 chr3 GO:0019221 Census, Compendium Yes 37 0.125 47 1 0.021 2
NMI NMI Q13287 N-myc-interactor chr2 GO:0019221 Not Cancer Driver No 34 0.111 104 12 0.115 0
NOTCH1 NOTCH1 P46531 Neurogenic locus notch homolog protein 1 chr9 GO:0019221 Census, Compendium Yes 363 0.142 686 87 0.127 3
NUMBL NUMBL Q9Y6R0 Numb-like protein chr19 GO:0019221 Not Cancer Driver No 42 0.069 467 23 0.049 0
OAS1_ENST00000202917 OAS1 P00973 2'-5'-oligoadenylate synthase 1 chr12 GO:0019221 Not Cancer Driver No 67 0.168 71 12 0.169 0
OAS2 OAS2 P29728 2'-5'-oligoadenylate synthase 2 chr12 GO:0019221 Not Cancer Driver No 141 0.196 47 14 0.298 0
OASL OASL Q15646 2'-5'-oligoadenylate synthase-like protein chr12 GO:0019221 Not Cancer Driver No 76 0.148 8 4 0.5 0
OSM OSM P13725 Oncostatin-M chr22 GO:0019221 Not Cancer Driver No 43 0.171 114 24 0.211 0
OSMR OSMR Q99650 Oncostatin-M-specific receptor subunit beta chr5 GO:0019221 Not Cancer Driver No 167 0.171 145 22 0.152 5
OXSR1 OXSR1 O95747 Serine/threonine-protein kinase OSR1 chr3 GO:0019221 Not Cancer Driver No 69 0.131 208 29 0.139 0
P4HB P4HB P07237 Protein disulfide-isomerase chr17 GO:0019221 Not Cancer Driver No 61 0.12 79 15 0.19 1
PDGFB PDGFB P01127 Platelet-derived growth factor subunit B chr22 GO:0019221 Census Yes 37 0.154 99 22 0.222 2
PF4 PF4 P02776 Platelet factor 4 chr4 GO:0019221 Not Cancer Driver No 13 0.129 0 0 0.0 0
PF4V1 PF4V1 P10720 Platelet factor 4 variant chr4 GO:0019221 Not Cancer Driver No 18 0.173 6 2 0.333 0
PIAS3 PIAS3 Q9Y6X2 E3 SUMO-protein ligase PIAS3 chr1 GO:0019221 Not Cancer Driver No 70 0.111 266 31 0.117 0
PLCB1 PLCB1 Q9NQ66 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 chr20 GO:0019221 Not Cancer Driver No 313 0.257 481 104 0.216 0
PLP2 PLP2 Q04941 Proteolipid protein 2 chrX GO:0019221 Not Cancer Driver No 40 0.263 10 3 0.3 0
PPBP PPBP P02775 Platelet basic protein chr4 GO:0019221 Not Cancer Driver No 30 0.234 21 8 0.381 0
PRKACA PRKACA P17612 cAMP-dependent protein kinase catalytic subunit alpha chr19 GO:0019221 Census Yes 53 0.151 24 0 0.0 2
PRLR PRLR P16471 Prolactin receptor chr5 GO:0019221 Not Cancer Driver No 154 0.248 282 70 0.248 2
PTK2B_ENST00000346049 PTK2B Q14289 Protein-tyrosine kinase 2-beta chr8 GO:0019221 Not Cancer Driver No 161 0.16 261 37 0.142 0
PTPN11_ENST00000351677 PTPN11 Q06124 Tyrosine-protein phosphatase non-receptor type 11 chr12 GO:0019221 Census, Compendium Yes 129 0.218 260 38 0.146 60
PTPN6_ENST00000318974 PTPN6 P29350 Tyrosine-protein phosphatase non-receptor type 6 chr12 GO:0019221 Census, Compendium Yes 73 0.123 192 25 0.13 0
PTPRJ PTPRJ Q12913 Receptor-type tyrosine-protein phosphatase eta chr11 GO:0019221 Not Cancer Driver No 184 0.138 401 61 0.152 0
RBM15 RBM15 Q96T37 RNA-binding protein 15 chr1 GO:0019221 Census, Compendium Yes 118 0.121 686 91 0.133 0
RELA RELA Q04206 Transcription factor p65 chr11 GO:0019221 Compendium Yes 75 0.136 400 48 0.12 0
RHEX RHEX Q6ZWK4 Regulator of hemoglobinization and erythroid cell expansion protein chr1 GO:0019221 Not Cancer Driver No 35 0.203 116 27 0.233 0
RPS6KA4 RPS6KA4 O75676 Ribosomal protein S6 kinase alpha-4 chr11 GO:0019221 Not Cancer Driver No 72 0.093 220 11 0.05 0
RPS6KA5 RPS6KA5 O75582 Ribosomal protein S6 kinase alpha-5 chr14 GO:0019221 Not Cancer Driver No 97 0.121 187 18 0.096 0
SH2B3 SH2B3 Q9UQQ2 SH2B adapter protein 3 chr12 GO:0019221 Census, Compendium Yes 48 0.083 333 19 0.057 0
SIRT1 SIRT1 Q96EB6 NAD-dependent protein deacetylase sirtuin-1 chr10 GO:0019221 Not Cancer Driver No 70 0.094 435 31 0.071 0
SLC1A1 SLC1A1 P43005 Excitatory amino acid transporter 3 chr9 GO:0019221 Not Cancer Driver No 69 0.132 17 4 0.235 1
SLC27A1 SLC27A1 Q6PCB7 Long-chain fatty acid transport protein 1 chr19 GO:0019221 Not Cancer Driver No 88 0.136 16 0 0.0 0
SMAD4_ENST00000398417 SMAD4 Q13485 Mothers against decapentaplegic homolog 4 chr18 GO:0019221 Census, Compendium Yes 198 0.359 195 17 0.087 8
SOCS1 SOCS1 O15524 Suppressor of cytokine signaling 1 chr16 GO:0019221 Census, Compendium Yes 22 0.104 66 3 0.045 2
SOCS5 SOCS5 O75159 Suppressor of cytokine signaling 5 chr2 GO:0019221 Not Cancer Driver No 84 0.157 297 46 0.155 0
SOS1_ENST00000402219 SOS1 Q07889 Son of sevenless homolog 1 chr2 GO:0019221 Compendium Yes 197 0.148 458 62 0.135 38
SP100_ENST00000264052 SP100 P23497 Nuclear autoantigen Sp-100 chr2 GO:0019221 Not Cancer Driver No 136 0.155 680 101 0.149 0
SPI1_ENST00000378538 SPI1 P17947 Transcription factor PU.1 chr11 GO:0019221 Not Cancer Driver No 46 0.17 187 34 0.182 0
SRC_ENST00000358208 SRC P12931 Proto-oncogene tyrosine-protein kinase Src chr20 GO:0019221 Census Yes 53 0.099 130 11 0.085 1
ST18 ST18 O60284 Suppression of tumorigenicity 18 protein chr8 GO:0019221 Not Cancer Driver No 330 0.315 820 282 0.344 0
STAT1 STAT1 P42224 Signal transducer and activator of transcription 1-alpha/beta chr2 GO:0019221 Not Cancer Driver No 131 0.175 144 25 0.174 26
STAT2 STAT2 P52630 Signal transducer and activator of transcription 2 chr12 GO:0019221 Not Cancer Driver No 90 0.106 178 22 0.124 2
STAT3 STAT3 P40763 Signal transducer and activator of transcription 3 chr17 GO:0019221 Census, Compendium Yes 110 0.143 152 15 0.099 19
STAT4_ENST00000358470 STAT4 Q14765 Signal transducer and activator of transcription 4 chr2 GO:0019221 Not Cancer Driver No 154 0.206 143 36 0.252 0
STAT5A_ENST00000590949 STAT5A P42229 Signal transducer and activator of transcription 5A chr17 GO:0019221 Not Cancer Driver No 89 0.112 125 14 0.112 0
STAT5B STAT5B P51692 Signal transducer and activator of transcription 5B chr17 GO:0019221 Census, Compendium Yes 93 0.118 144 19 0.132 5
STAT6_ENST00000543873 STAT6 P42226 Signal transducer and activator of transcription 6 chr12 GO:0019221 Census, Compendium Yes 106 0.125 325 44 0.135 0
STK39 STK39 Q9UEW8 STE20/SPS1-related proline-alanine-rich protein kinase chr2 GO:0019221 Not Cancer Driver No 64 0.117 182 19 0.104 0
SYK_ENST00000375746 SYK P43405 Tyrosine-protein kinase SYK chr9 GO:0019221 Census Yes 96 0.151 131 27 0.206 5
TFF2 TFF2 Q03403 Trefoil factor 2 chr21 GO:0019221 Not Cancer Driver No 16 0.124 0 0 0.0 0
THPO THPO P40225 Thrombopoietin chr3 GO:0019221 Not Cancer Driver No 63 0.178 163 25 0.153 0
TNFRSF11A TNFRSF11A Q9Y6Q6 Tumor necrosis factor receptor superfamily member 11A chr18 GO:0019221 Not Cancer Driver No 70 0.114 285 33 0.116 0
TNFRSF1A TNFRSF1A P19438 Tumor necrosis factor receptor superfamily member 1A chr12 GO:0019221 Not Cancer Driver No 58 0.127 111 15 0.135 12
TNFSF11 TNFSF11 O14788 Tumor necrosis factor ligand superfamily member 11 chr13 GO:0019221 Not Cancer Driver No 52 0.164 56 1 0.018 1
TNIP2 TNIP2 Q8NFZ5 TNFAIP3-interacting protein 2 chr4 GO:0019221 Not Cancer Driver No 43 0.1 316 36 0.114 0
TOLLIP TOLLIP Q9H0E2 Toll-interacting protein chr11 GO:0019221 Not Cancer Driver No 38 0.139 81 12 0.148 0
TP53_ENST00000445888 TP53 P04637 Cellular tumor antigen p53 chr17 GO:0019221 Census, Compendium Yes 2891 7.356 282 1466 5.199 83
TRAF2 TRAF2 Q12933 TNF receptor-associated factor 2 chr9 GO:0019221 Not Cancer Driver No 63 0.126 4 1 0.25 0
TRAF3IP2_ENST00000392556 TRAF3IP2 O43734 E3 ubiquitin ligase TRAF3IP2 chr6 GO:0019221 Not Cancer Driver No 59 0.103 410 39 0.095 2
TRAF5_ENST00000336184 TRAF5 O00463 TNF receptor-associated factor 5 chr1 GO:0019221 Not Cancer Driver No 61 0.11 59 5 0.085 0
TRAF6_ENST00000348124 TRAF6 Q9Y4K3 TNF receptor-associated factor 6 chr11 GO:0019221 Not Cancer Driver No 67 0.128 62 7 0.113 0
TREM2 TREM2 Q9NZC2 Triggering receptor expressed on myeloid cells 2 chr6 GO:0019221 Not Cancer Driver No 43 0.187 27 2 0.074 1
TYK2 TYK2 P29597 Non-receptor tyrosine-protein kinase TYK2 chr19 GO:0019221 Not Cancer Driver No 148 0.125 213 29 0.136 0
UGCG UGCG Q16739 Ceramide glucosyltransferase chr9 GO:0019221 Not Cancer Driver No 37 0.094 0 0 0.0 0
WBP1L_ENST00000369889 WBP1L Q9NX94 WW domain binding protein 1-like chr10 GO:0019221 Not Cancer Driver No 27 0.079 225 21 0.093 0
WNK1_ENST00000315939 WNK1 Q9H4A3 Serine/threonine-protein kinase WNK1 chr12 GO:0019221 Not Cancer Driver No 278 0.117 1959 223 0.114 0
XCL1 XCL1 P47992 Lymphotactin chr1 GO:0019221 Not Cancer Driver No 28 0.246 35 11 0.314 0
XCL2 XCL2 Q9UBD3 Cytokine SCM-1 beta chr1 GO:0019221 Not Cancer Driver No 20 0.175 35 5 0.143 0
XCR1 XCR1 P46094 Chemokine XC receptor 1 chr3 GO:0019221 Not Cancer Driver No 66 0.198 1 0 0.0 0
YAP1_ENST00000282441 YAP1 P46937 Transcriptional coactivator YAP1 chr11 GO:0019221 Not Cancer Driver No 51 0.101 489 49 0.1 0
ZC3H15 ZC3H15 Q8WU90 Zinc finger CCCH domain-containing protein 15 chr2 GO:0019221 Not Cancer Driver No 58 0.136 281 44 0.157 0
ZNF675 ZNF675 Q8TD23 Zinc finger protein 675 chr19 GO:0019221 Not Cancer Driver No 114 0.201 91 19 0.209 0