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Total number of protein in "GO:0007584" GO term:  138

Identifier
UniProt Gene
UniProt Accession
UniProt Name
Chromosome
GO term
Database
Cancer Driver
Number of missense mutations
Missense mutation per residues
Number of disordered residues
Number of mutations in disordered regions
Disordered missense mutations per residues
Number of OMIM mutation
A2M A2M P01023 Alpha-2-macroglobulin chr12 GO:0007584 Not Cancer Driver No 260 0.176 144 22 0.153 0
ABCG5_ENST00000405322 ABCG5 Q9H222 ATP-binding cassette sub-family G member 5 chr2 GO:0007584 Not Cancer Driver No 77 0.118 43 8 0.186 6
ABCG8 ABCG8 Q9H221 ATP-binding cassette sub-family G member 8 chr2 GO:0007584 Not Cancer Driver No 137 0.204 40 8 0.2 10
ACSL1_ENST00000281455 ACSL1 P33121 Long-chain-fatty-acid--CoA ligase 1 chr4 GO:0007584 Not Cancer Driver No 85 0.122 27 1 0.037 0
ADIPOQ ADIPOQ Q15848 Adiponectin chr3 GO:0007584 Not Cancer Driver No 39 0.16 92 21 0.228 1
ADSL ADSL P30566 Adenylosuccinate lyase chr22 GO:0007584 Not Cancer Driver No 68 0.14 36 9 0.25 27
AGL_ENST00000361915 AGL P35573 Glycogen debranching enzyme chr1 GO:0007584 Not Cancer Driver No 182 0.119 143 23 0.161 1
AKR1C3 AKR1C3 P42330 Aldo-keto reductase family 1 member C3 chr10 GO:0007584 Not Cancer Driver No 49 0.152 11 1 0.091 0
ALAD ALAD P13716 Delta-aminolevulinic acid dehydratase chr9 GO:0007584 Not Cancer Driver No 52 0.158 13 3 0.231 5
ALDH1A2 ALDH1A2 O94788 Retinal dehydrogenase 2 chr15 GO:0007584 Not Cancer Driver No 100 0.193 56 13 0.232 0
ALPL ALPL P05186 Alkaline phosphatase, tissue-nonspecific isozyme chr1 GO:0007584 Not Cancer Driver No 80 0.153 184 39 0.212 113
AMELX_ENST00000380714 AMELX Q99217 Amelogenin, X isoform chrX GO:0007584 Not Cancer Driver No 40 0.209 127 28 0.22 3
APAF1 APAF1 O14727 Apoptotic protease-activating factor 1 chr12 GO:0007584 Not Cancer Driver No 127 0.102 17 1 0.059 0
AQP3 AQP3 Q92482 Aquaporin-3 chr9 GO:0007584 Not Cancer Driver No 34 0.116 12 0 0.0 0
ARG1_ENST00000368087 ARG1 P05089 Arginase-1 chr6 GO:0007584 Not Cancer Driver No 41 0.127 83 12 0.145 9
ARSB ARSB P15848 Arylsulfatase B chr5 GO:0007584 Not Cancer Driver No 59 0.111 81 6 0.074 29
ASCL1 ASCL1 P50553 Achaete-scute homolog 1 chr12 GO:0007584 Not Cancer Driver No 33 0.14 182 24 0.132 0
ASS1_ENST00000352480 ASS1 P00966 Argininosuccinate synthase chr9 GO:0007584 Not Cancer Driver No 65 0.158 63 8 0.127 86
ATP2B1_ENST00000261173 ATP2B1 P20020 Plasma membrane calcium-transporting ATPase 1 chr12 GO:0007584 Not Cancer Driver No 143 0.117 293 42 0.143 0
BCHE BCHE P06276 Cholinesterase chr3 GO:0007584 Not Cancer Driver No 185 0.307 14 4 0.286 38
BCKDHB BCKDHB P21953 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial chr6 GO:0007584 Not Cancer Driver No 47 0.12 23 3 0.13 5
BECN1_ENST00000590099 BECN1 Q14457 Beclin-1 chr17 GO:0007584 Not Cancer Driver No 45 0.1 190 19 0.1 0
BGLAP BGLAP P02818 Osteocalcin chr1 GO:0007584 Not Cancer Driver No 13 0.13 21 2 0.095 0
BMP7 BMP7 P18075 Bone morphogenetic protein 7 chr20 GO:0007584 Not Cancer Driver No 91 0.211 69 18 0.261 0
BRIP1 BRIP1 Q9BX63 Fanconi anemia group J protein chr17 GO:0007584 Census Yes 174 0.139 397 59 0.149 6
CASR_ENST00000638421 CASR P41180 Extracellular calcium-sensing receptor chr3 GO:0007584 Not Cancer Driver No 304 0.282 189 60 0.317 108
CAT CAT P04040 Catalase chr11 GO:0007584 Not Cancer Driver No 70 0.133 176 18 0.102 0
CCL28 CCL28 Q9NRJ3 C-C motif chemokine 28 chr5 GO:0007584 Not Cancer Driver No 17 0.134 48 8 0.167 0
CCND1 CCND1 P24385 G1/S-specific cyclin-D1 chr11 GO:0007584 Census, Compendium Yes 55 0.186 31 25 0.806 0
CDKN2B CDKN2B P42772 Cyclin-dependent kinase 4 inhibitor B chr9 GO:0007584 Not Cancer Driver No 15 0.109 67 3 0.045 0
CDKN2D_ENST00000335766 CDKN2D P55273 Cyclin-dependent kinase 4 inhibitor D chr19 GO:0007584 Not Cancer Driver No 17 0.102 44 3 0.068 0
CNR1_ENST00000549890 CNR1 P21554 Cannabinoid receptor 1 chr6 GO:0007584 Not Cancer Driver No 129 0.273 9 1 0.111 0
COL1A1 COL1A1 P02452 Collagen alpha-1(I) chain chr17 GO:0007584 Census, Compendium Yes 247 0.169 1212 214 0.177 148
CXCL10 CXCL10 P02778 C-X-C motif chemokine 10 chr4 GO:0007584 Not Cancer Driver No 19 0.194 12 4 0.333 0
CYBB CYBB P04839 Cytochrome b-245 heavy chain chrX GO:0007584 Not Cancer Driver No 109 0.191 11 3 0.273 65
CYP1A1 CYP1A1 P04798 Cytochrome P450 1A1 chr15 GO:0007584 Not Cancer Driver No 81 0.158 17 2 0.118 0
CYP1B1 CYP1B1 Q16678 Cytochrome P450 1B1 chr2 GO:0007584 Not Cancer Driver No 61 0.112 31 3 0.097 40
CYP24A1 CYP24A1 Q07973 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial chr20 GO:0007584 Not Cancer Driver No 74 0.144 77 5 0.065 4
CYP26A1 CYP26A1 O43174 Cytochrome P450 26A1 chr10 GO:0007584 Not Cancer Driver No 84 0.169 9 1 0.111 0
CYP26B1 CYP26B1 Q9NR63 Cytochrome P450 26B1 chr2 GO:0007584 Not Cancer Driver No 113 0.221 10 3 0.3 2
CYP27B1 CYP27B1 O15528 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial chr12 GO:0007584 Not Cancer Driver No 71 0.14 79 13 0.165 18
DAD1 DAD1 P61803 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 chr14 GO:0007584 Not Cancer Driver No 7 0.062 0 0 0.0 0
DCPS DCPS Q96C86 m7GpppX diphosphatase chr11 GO:0007584 Not Cancer Driver No 48 0.142 53 6 0.113 1
DNMT3A DNMT3A Q9Y6K1 DNA (cytosine-5)-methyltransferase 3A chr2 GO:0007584 Census, Compendium Yes 194 0.213 371 59 0.159 16
ENSA_ENST00000369014 ENSA O43768 Alpha-endosulfine chr1 GO:0007584 Not Cancer Driver No 15 0.124 121 15 0.124 0
EPO EPO P01588 Erythropoietin chr7 GO:0007584 Not Cancer Driver No 27 0.14 9 1 0.111 1
ERCC1_ENST00000589165 ERCC1 P07992 DNA excision repair protein ERCC-1 chr19 GO:0007584 Not Cancer Driver No 42 0.141 105 14 0.133 1
F5 F5 P12259 Coagulation factor V chr1 GO:0007584 Not Cancer Driver No 455 0.205 974 223 0.229 7
F7 F7 P08709 Coagulation factor VII chr13 GO:0007584 Not Cancer Driver No 74 0.159 50 7 0.14 108
FES FES P07332 Tyrosine-protein kinase Fes/Fps chr15 GO:0007584 Census Yes 103 0.125 245 34 0.139 0
FGF23 FGF23 Q9GZV9 Fibroblast growth factor 23 chr12 GO:0007584 Not Cancer Driver No 84 0.335 97 51 0.526 7
FKBP1B FKBP1B P68106 Peptidyl-prolyl cis-trans isomerase FKBP1B chr2 GO:0007584 Not Cancer Driver No 10 0.093 58 4 0.069 0
FOLR1_ENST00000393681 FOLR1 P15328 Folate receptor alpha chr11 GO:0007584 Not Cancer Driver No 41 0.16 13 3 0.231 0
FOLR2 FOLR2 P14207 Folate receptor beta chr11 GO:0007584 Not Cancer Driver No 32 0.125 6 0 0.0 0
FOXA2_ENST00000377115 FOXA2 Q9Y261 Hepatocyte nuclear factor 3-beta chr20 GO:0007584 Compendium Yes 70 0.153 258 34 0.132 0
GAS6 GAS6 Q14393 Growth arrest-specific protein 6 chr13 GO:0007584 Not Cancer Driver No 82 0.121 42 6 0.143 0
GATA4_ENST00000335135 GATA4 P43694 Transcription factor GATA-4 chr8 GO:0007584 Not Cancer Driver No 48 0.109 301 34 0.113 18
GCGR GCGR P47871 Glucagon receptor chr17 GO:0007584 Not Cancer Driver No 16 0.034 56 2 0.036 4
GCLC GCLC P48506 Glutamate--cysteine ligase catalytic subunit chr6 GO:0007584 Not Cancer Driver No 73 0.115 167 18 0.108 3
GCLM GCLM P48507 Glutamate--cysteine ligase regulatory subunit chr1 GO:0007584 Not Cancer Driver No 32 0.117 31 3 0.097 0
GDAP1 GDAP1 Q8TB36 Ganglioside-induced differentiation-associated protein 1 chr8 GO:0007584 Not Cancer Driver No 51 0.142 78 14 0.179 11
GIPR GIPR P48546 Gastric inhibitory polypeptide receptor chr19 GO:0007584 Not Cancer Driver No 45 0.097 41 0 0.0 0
GNAI2 GNAI2 P04899 Guanine nucleotide-binding protein G(i) subunit alpha-2 chr3 GO:0007584 Compendium Yes 50 0.141 24 0 0.0 0
GNPAT GNPAT O15228 Dihydroxyacetone phosphate acyltransferase chr1 GO:0007584 Not Cancer Driver No 86 0.126 6 3 0.5 3
GPX1_ENST00000620890 GPX1 P07203 Glutathione peroxidase 1 chr3 GO:0007584 Not Cancer Driver No 38 0.187 12 1 0.083 0
HAMP_ENST00000222304 HAMP P81172 Hepcidin chr19 GO:0007584 Not Cancer Driver No 7 0.083 4 0 0.0 4
HLCS HLCS P50747 Biotin--protein ligase chr21 GO:0007584 Not Cancer Driver No 95 0.131 158 15 0.095 23
HMGCS2 HMGCS2 P54868 Hydroxymethylglutaryl-CoA synthase, mitochondrial chr1 GO:0007584 Not Cancer Driver No 92 0.181 29 4 0.138 19
HMOX1 HMOX1 P09601 Heme oxygenase 1 chr22 GO:0007584 Not Cancer Driver No 46 0.16 81 13 0.16 0
HSF1 HSF1 Q00613 Heat shock factor protein 1 chr8 GO:0007584 Not Cancer Driver No 59 0.112 335 37 0.11 0
IGF1R IGF1R P08069 Insulin-like growth factor 1 receptor chr15 GO:0007584 Not Cancer Driver No 183 0.134 265 37 0.14 6
IGFBP2 IGFBP2 P18065 Insulin-like growth factor-binding protein 2 chr2 GO:0007584 Not Cancer Driver No 32 0.098 171 24 0.14 0
IL15_ENST00000320650 IL15 P40933 Interleukin-15 chr4 GO:0007584 Not Cancer Driver No 25 0.154 6 1 0.167 0
IL1A IL1A P01583 Interleukin-1 alpha chr2 GO:0007584 Not Cancer Driver No 30 0.111 35 6 0.171 0
ITGA2 ITGA2 P17301 Integrin alpha-2 chr5 GO:0007584 Not Cancer Driver No 166 0.141 26 0 0.0 0
KL KL Q9UEF7 Klotho chr13 GO:0007584 Not Cancer Driver No 175 0.173 104 5 0.048 1
KYNU_ENST00000409512 KYNU Q16719 Kynureninase chr2 GO:0007584 Not Cancer Driver No 103 0.222 20 5 0.25 1
LEP LEP P41159 Leptin chr7 GO:0007584 Not Cancer Driver No 29 0.174 0 0 0.0 2
LIPG LIPG Q9Y5X9 Endothelial lipase chr18 GO:0007584 Not Cancer Driver No 90 0.18 59 7 0.119 0
LPL LPL P06858 Lipoprotein lipase chr8 GO:0007584 Not Cancer Driver No 94 0.198 23 3 0.13 70
LRAT LRAT O95237 Lecithin retinol acyltransferase chr4 GO:0007584 Not Cancer Driver No 54 0.235 2 0 0.0 1
LTA LTA P01374 Lymphotoxin-alpha chr6 GO:0007584 Not Cancer Driver No 37 0.18 20 5 0.25 0
MAP1B MAP1B P46821 Microtubule-associated protein 1B chr5 GO:0007584 Not Cancer Driver No 332 0.135 1947 278 0.143 0
MTHFR_ENST00000376590 MTHFR P42898 Methylenetetrahydrofolate reductase chr1 GO:0007584 Not Cancer Driver No 95 0.145 125 22 0.176 53
MTOR MTOR P42345 Serine/threonine-protein kinase mTOR chr1 GO:0007584 Census, Compendium Yes 379 0.149 296 37 0.125 18
NCOA1_ENST00000348332 NCOA1 Q15788 Nuclear receptor coactivator 1 chr2 GO:0007584 Census, Compendium Yes 188 0.13 1217 149 0.122 0
NDOR1_ENST00000344894 NDOR1 Q9UHB4 NADPH-dependent diflavin oxidoreductase 1 chr9 GO:0007584 Not Cancer Driver No 60 0.101 67 7 0.104 0
NOD2 NOD2 Q9HC29 Nucleotide-binding oligomerization domain-containing protein 2 chr16 GO:0007584 Not Cancer Driver No 169 0.163 40 4 0.1 15
NQO1 NQO1 P15559 NAD(P)H dehydrogenase [quinone] 1 chr16 GO:0007584 Not Cancer Driver No 21 0.077 10 1 0.1 0
NR1H4 NR1H4 Q96RI1 Bile acid receptor chr12 GO:0007584 Not Cancer Driver No 111 0.228 78 18 0.231 0
OGG1_ENST00000344629 OGG1 O15527 N-glycosylase/DNA lyase chr3 GO:0007584 Not Cancer Driver No 37 0.107 71 12 0.169 0
OGT OGT O15294 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit chrX GO:0007584 Not Cancer Driver No 156 0.149 89 16 0.18 2
OTC OTC P00480 Ornithine transcarbamylase, mitochondrial chrX GO:0007584 Not Cancer Driver No 89 0.251 24 4 0.167 111
OXCT1 OXCT1 P55809 Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial chr5 GO:0007584 Not Cancer Driver No 80 0.154 39 5 0.128 11
PDK2 PDK2 Q15119 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial chr17 GO:0007584 Not Cancer Driver No 45 0.111 35 4 0.114 0
PDX1 PDX1 P52945 Pancreas/duodenum homeobox protein 1 chr13 GO:0007584 Not Cancer Driver No 32 0.113 238 23 0.097 0
PENK_ENST00000451791 PENK P01210 Proenkephalin-A chr8 GO:0007584 Not Cancer Driver No 109 0.408 142 62 0.437 0
PHEX PHEX P78562 Phosphate-regulating neutral endopeptidase PHEX chrX GO:0007584 Not Cancer Driver No 144 0.192 56 7 0.125 30
PKLR PKLR P30613 Pyruvate kinase PKLR chr1 GO:0007584 Not Cancer Driver No 112 0.195 26 5 0.192 101
POR POR P16435 NADPH--cytochrome P450 reductase chr7 GO:0007584 Not Cancer Driver No 62 0.092 93 4 0.043 9
POSTN POSTN Q15063 Periostin chr13 GO:0007584 Not Cancer Driver No 204 0.244 86 27 0.314 0
PPARD_ENST00000360694 PPARD Q03181 Peroxisome proliferator-activated receptor delta chr6 GO:0007584 Not Cancer Driver No 72 0.163 69 7 0.101 0
PPARG PPARG P37231 Peroxisome proliferator-activated receptor gamma chr3 GO:0007584 Census Yes 72 0.143 44 4 0.091 3
PTGS2 PTGS2 P35354 Prostaglandin G/H synthase 2 chr1 GO:0007584 Not Cancer Driver No 105 0.174 30 5 0.167 0
PTH PTH P01270 Parathyroid hormone chr11 GO:0007584 Not Cancer Driver No 19 0.165 60 10 0.167 2
RARA RARA P10276 Retinoic acid receptor alpha chr17 GO:0007584 Census, Compendium Yes 70 0.152 167 14 0.084 0
RPS6KB1 RPS6KB1 P23443 Ribosomal protein S6 kinase beta-1 chr17 GO:0007584 Not Cancer Driver No 45 0.086 226 26 0.115 0
SFRP1 SFRP1 Q8N474 Secreted frizzled-related protein 1 chr8 GO:0007584 Not Cancer Driver No 40 0.127 39 7 0.179 0
SFRP2 SFRP2 Q96HF1 Secreted frizzled-related protein 2 chr4 GO:0007584 Not Cancer Driver No 47 0.159 1 0 0.0 0
SHANK2_ENST00000601538 SHANK2 Q9UPX8 SH3 and multiple ankyrin repeat domains protein 2 chr11 GO:0007584 Not Cancer Driver No 303 0.164 1379 262 0.19 0
SLC27A4 SLC27A4 Q6P1M0 Long-chain fatty acid transport protein 4 chr9 GO:0007584 Not Cancer Driver No 83 0.129 27 3 0.111 5
SLC34A1 SLC34A1 Q06495 Sodium-dependent phosphate transport protein 2A chr5 GO:0007584 Not Cancer Driver No 92 0.144 46 8 0.174 9
SLC6A19 SLC6A19 Q695T7 Sodium-dependent neutral amino acid transporter B(0)AT1 chr5 GO:0007584 Not Cancer Driver No 130 0.205 1 0 0.0 14
SLC6A4_ENST00000401766 SLC6A4 P31645 Sodium-dependent serotonin transporter chr17 GO:0007584 Not Cancer Driver No 101 0.16 73 12 0.164 0
SLC8A1_ENST00000332839 SLC8A1 P32418 Sodium/calcium exchanger 1 chr2 GO:0007584 Not Cancer Driver No 305 0.313 158 48 0.304 0
SOD2_ENST00000367055 SOD2 P04179 Superoxide dismutase [Mn], mitochondrial chr6 GO:0007584 Not Cancer Driver No 32 0.144 25 5 0.2 0
SPP1 SPP1 P10451 Osteopontin chr4 GO:0007584 Not Cancer Driver No 56 0.178 296 54 0.182 0
SRF SRF P11831 Serum response factor chr6 GO:0007584 Not Cancer Driver No 44 0.087 443 42 0.095 0
SRSF2 SRSF2 Q01130 Serine/arginine-rich splicing factor 2 chr17 GO:0007584 Census, Compendium Yes 38 0.172 219 38 0.174 0
SST SST P61278 Somatostatin chr3 GO:0007584 Not Cancer Driver No 25 0.216 40 15 0.375 0
STAT1 STAT1 P42224 Signal transducer and activator of transcription 1-alpha/beta chr2 GO:0007584 Not Cancer Driver No 131 0.175 144 25 0.174 26
STC1 STC1 P52823 Stanniocalcin-1 chr8 GO:0007584 Not Cancer Driver No 59 0.239 58 12 0.207 0
STC2 STC2 O76061 Stanniocalcin-2 chr5 GO:0007584 Not Cancer Driver No 71 0.235 112 29 0.259 0
TBXA2R_ENST00000375190 TBXA2R P21731 Thromboxane A2 receptor chr19 GO:0007584 Not Cancer Driver No 47 0.137 17 4 0.235 1
TFRC_ENST00000392396 TFRC P02786 Transferrin receptor protein 1 chr3 GO:0007584 Census Yes 89 0.117 80 6 0.075 1
TGFBR2_ENST00000295754 TGFBR2 P37173 TGF-beta receptor type-2 chr3 GO:0007584 Census, Compendium Yes 106 0.187 60 16 0.267 25
TNFRSF11B TNFRSF11B O00300 Tumor necrosis factor receptor superfamily member 11B chr8 GO:0007584 Not Cancer Driver No 79 0.197 17 3 0.176 0
TRIM25 TRIM25 Q14258 E3 ubiquitin/ISG15 ligase TRIM25 chr17 GO:0007584 Not Cancer Driver No 59 0.094 225 20 0.089 0
TSHB_ENST00000369517 TSHB P01222 Thyrotropin subunit beta chr1 GO:0007584 Not Cancer Driver No 34 0.246 0 0 0.0 0
TSPO_ENST00000329563 TSPO P30536 Translocator protein chr22 GO:0007584 Not Cancer Driver No 5 0.03 1 0 0.0 0
TYMS TYMS P04818 Thymidylate synthase chr18 GO:0007584 Not Cancer Driver No 22 0.07 41 0 0.0 0
TYR TYR P14679 Tyrosinase chr11 GO:0007584 Not Cancer Driver No 156 0.295 52 15 0.288 111
UCP3 UCP3 P55916 Mitochondrial uncoupling protein 3 chr11 GO:0007584 Not Cancer Driver No 37 0.119 7 1 0.143 1
UGT1A1 UGT1A1 P22309 UDP-glucuronosyltransferase 1A1 chr2 GO:0007584 Not Cancer Driver No 100 0.188 11 2 0.182 55
USF1 USF1 P22415 Upstream stimulatory factor 1 chr1 GO:0007584 Not Cancer Driver No 52 0.168 271 44 0.162 0
USF2 USF2 Q15853 Upstream stimulatory factor 2 chr19 GO:0007584 Not Cancer Driver No 30 0.087 326 29 0.089 0
VCAM1 VCAM1 P19320 Vascular cell adhesion protein 1 chr1 GO:0007584 Not Cancer Driver No 188 0.254 110 28 0.255 0
XBP1 XBP1 P17861 X-box-binding protein 1 chr22 GO:0007584 Not Cancer Driver No 19 0.073 169 9 0.053 0