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ECE1 ,ECE1 ,P42892
  • Uniprot Accession= P42892
  • Ensembl Transcript= ENST00000374893.10
  • Uniprot Name= ECE1
  • Name= Endothelin-converting enzyme 1
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of GO Term: 94
GO term GO name GO namespace GO def
GO:0007409 axonogenesis biological_process De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells. [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732]
GO:0006508 proteolysis biological_process The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah]
GO:0032501 multicellular organismal process biological_process Any biological process, occurring at the level of a multicellular organism, pertinent to its function. [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb]
GO:0007507 heart development biological_process The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. [GOC:jid, UBERON:0000948]
GO:0048858 cell projection morphogenesis biological_process The process in which the anatomical structures of a cell projection are generated and organized. [GO_REF:0000021]
GO:0007166 cell surface receptor signaling pathway biological_process A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription. [GOC:bf, GOC:mah, GOC:pr, GOC:signaling]
GO:0030030 cell projection organization biological_process A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon. [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/]
GO:0043231 intracellular membrane-bounded organelle cellular_component Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators]
GO:0003013 circulatory system process biological_process A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism. [GOC:mtg_cardio]
GO:0005886 plasma membrane cellular_component The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
GO:0048518 positive regulation of biological process biological_process Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. [GOC:jid]
GO:0099503 secretory vesicle cellular_component A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space. [GOC:dos]
GO:0008217 regulation of blood pressure biological_process Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. [GOC:dph, GOC:mtg_cardio, ISBN:0721643949]
GO:0032989 cellular component morphogenesis biological_process The process in which cellular structures, including whole cells or cell parts, are generated and organized. [GOC:dph, GOC:mah, GOC:tb]
GO:0044237 cellular metabolic process biological_process The chemical reactions and pathways by which individual cells transform chemical substances. [GOC:go_curators]
GO:0007411 axon guidance biological_process The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. [ISBN:0878932437]
GO:0035050 embryonic heart tube development biological_process The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field. [GOC:go_curators]
GO:0010604 positive regulation of macromolecule metabolic process biological_process Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. [GOC:dph, GOC:tb]
GO:0009987 cellular process biological_process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. [GOC:go_curators, GOC:isa_complete]
GO:0016021 integral component of membrane cellular_component The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:dos, GOC:go_curators]
GO:0071704 organic substance metabolic process biological_process The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon. [GOC:mah]
GO:0005515 protein binding molecular_function Binding to a protein. [GOC:go_curators]
GO:0005765 lysosomal membrane cellular_component The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. [GOC:ai]
GO:0051604 protein maturation biological_process Any process leading to the attainment of the full functional capacity of a protein. [GOC:ai]
GO:0032990 cell part morphogenesis biological_process The process in which the anatomical structures of a cell part are generated and organized. [GOC:mah]
GO:0030141 secretory granule cellular_component A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules. [GOC:mah, ISBN:0198506732]
GO:0071840 cellular component organization or biogenesis biological_process A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component. [GOC:mah]
GO:0060255 regulation of macromolecule metabolic process biological_process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. [GOC:dph, GOC:tb]
GO:0009653 anatomical structure morphogenesis biological_process The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form. [GOC:go_curators, ISBN:0521436125]
GO:0009056 catabolic process biological_process The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism. [ISBN:0198547684]
GO:0042803 protein homodimerization activity molecular_function Binding to an identical protein to form a homodimer. [GOC:jl]
GO:0090066 regulation of anatomical structure size biological_process Any process that modulates the size of an anatomical structure. [GOC:dph, GOC:tb]
GO:0048471 perinuclear region of cytoplasm cellular_component Cytoplasm situated near, or occurring around, the nucleus. [GOC:jid]
GO:0019538 protein metabolic process biological_process The chemical reactions and pathways involving a protein. Includes protein modification. [GOC:ma]
GO:0006807 nitrogen compound metabolic process biological_process The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen. [GOC:jl, ISBN:0198506732]
GO:0031325 positive regulation of cellular metabolic process biological_process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. [GOC:mah]
GO:0032502 developmental process biological_process A biological process whose specific outcome is the progression of an integrated living unit
GO:0031982 vesicle cellular_component Any small, fluid-filled, spherical organelle enclosed by membrane. [GOC:mah, GOC:pz, GOC:vesicles]
GO:0065007 biological regulation biological_process Any process that modulates a measurable attribute of any biological process, quality or function. [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]
GO:0043603 cellular amide metabolic process biological_process The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells. [GOC:curators]
GO:0016020 membrane cellular_component A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
GO:0110165 cellular anatomical entity cellular_component A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex. [GOC:kmv]
GO:0048856 anatomical structure development biological_process The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. [GO_REF:0000021]
GO:0034641 cellular nitrogen compound metabolic process biological_process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells. [GOC:mah]
GO:0005768 endosome cellular_component A vacuole to which materials ingested by endocytosis are delivered. [ISBN:0198506732, PMID:19696797]
GO:0023056 positive regulation of signaling biological_process Any process that activates, maintains or increases the frequency, rate or extent of a signaling process. [GOC:mtg_signal]
GO:0007186 G protein-coupled receptor signaling pathway biological_process A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]
GO:0043583 ear development biological_process The process whose specific outcome is the progression of the ear over time, from its formation to the mature structure. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals. [GOC:jl, ISBN:0192801023]
GO:0031224 intrinsic component of membrane cellular_component The component of a membrane consisting of the gene products having some covalently attached portion, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, which spans or is embedded in one or both leaflets of the membrane. [GOC:mah]
GO:0030135 coated vesicle cellular_component Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins. [ISBN:0815316194]
GO:0048869 cellular developmental process biological_process A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition. [GOC:isa_complete]
GO:0016043 cellular component organization biological_process A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. [GOC:ai, GOC:jl, GOC:mah]
GO:0048598 embryonic morphogenesis biological_process The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants. [GOC:jid, GOC:mtg_sensu]
GO:0019222 regulation of metabolic process biological_process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. [GOC:go_curators]
GO:0097746 blood vessel diameter maintenance biological_process Any process that modulates the diameter of blood vessels. [GOC:pr]
GO:0050789 regulation of biological process biological_process Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. [GOC:ai, GOC:go_curators]
GO:0006928 movement of cell or subcellular component biological_process The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore. [GOC:dgh, GOC:dph, GOC:jl, GOC:mlg]
GO:0097485 neuron projection guidance biological_process The process in which the migration of a neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues. [GOC:BHF, GOC:rl, PMID:22790009]
GO:0050794 regulation of cellular process biological_process Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. [GOC:go_curators]
GO:0003073 regulation of systemic arterial blood pressure biological_process The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. [GOC:mtg_cardio]
GO:0044057 regulation of system process biological_process Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system. [GOC:jl]
GO:0003008 system process biological_process A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective. [GOC:mtg_cardio]
GO:0031410 cytoplasmic vesicle cellular_component A vesicle found in the cytoplasm of a cell. [GOC:ai, GOC:mah, GOC:vesicles]
GO:0017046 peptide hormone binding molecular_function Binding to a peptide with hormonal activity in animals. [GOC:jl, ISBN:0198506732]
GO:0044238 primary metabolic process biological_process The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. [GOC:go_curators, http://www.metacyc.org]
GO:0048812 neuron projection morphogenesis biological_process The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites. [GOC:mah]
GO:0006518 peptide metabolic process biological_process The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. [GOC:go_curators]
GO:0120039 plasma membrane bounded cell projection morphogenesis biological_process The process in which the anatomical structures of a plasma membrane bounded cell projection are generated and organized. [GOC:krc]
GO:0043170 macromolecule metabolic process biological_process The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. [GOC:mah]
GO:0009897 external side of plasma membrane cellular_component The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb]
GO:0031323 regulation of cellular metabolic process biological_process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. [GOC:mah]
GO:0004175 endopeptidase activity molecular_function Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
GO:0031300 intrinsic component of organelle membrane cellular_component The component of the organelle membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:dos, GOC:mah]
GO:0030136 clathrin-coated vesicle cellular_component A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes. [GOC:mah, PMID:11252894]
GO:0044248 cellular catabolic process biological_process The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. [GOC:jl]
GO:0009893 positive regulation of metabolic process biological_process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. [GOC:go_curators]
GO:0007165 signal transduction biological_process The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11]
GO:1901564 organonitrogen compound metabolic process biological_process The chemical reactions and pathways involving organonitrogen compound. [GOC:pr, GOC:TermGenie]
GO:0008270 zinc ion binding molecular_function Binding to a zinc ion (Zn). [GOC:ai]
GO:0051239 regulation of multicellular organismal process biological_process Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs. [GOC:ai, GOC:dph, GOC:tb]
GO:0097708 intracellular vesicle cellular_component Any vesicle that is part of the intracellular region. [GOC:vesicles]
GO:0016485 protein processing biological_process Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein. [GOC:curators, GOC:jl, GOC:jsg]
GO:0008152 metabolic process biological_process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. [GOC:go_curators, ISBN:0198547684]
GO:1901565 organonitrogen compound catabolic process biological_process The chemical reactions and pathways resulting in the breakdown of organonitrogen compound. [GOC:pr, GOC:TermGenie]
GO:1901575 organic substance catabolic process biological_process The chemical reactions and pathways resulting in the breakdown of an organic substance, any molecular entity containing carbon. [GOC:pr, GOC:TermGenie]
GO:0010817 regulation of hormone levels biological_process Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. [GOC:BHF, GOC:dph, GOC:tb]
GO:0065008 regulation of biological quality biological_process Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc. [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw]
GO:0043227 membrane-bounded organelle cellular_component Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators]
GO:0048731 system development biological_process The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. [GOC:dph, GOC:jid]
GO:0004222 metalloendopeptidase activity molecular_function Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]
GO:0043229 intracellular organelle cellular_component Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. [GOC:go_curators]
GO:0023051 regulation of signaling biological_process Any process that modulates the frequency, rate or extent of a signaling process. [GOC:mtg_signal]
GO:0048522 positive regulation of cellular process biological_process Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. [GOC:jid]
GO:0043226 organelle cellular_component Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane. [GOC:go_curators]