| GO term | GO name | GO namespace | GO def |
| GO:0003682 | chromatin binding | molecular_function | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. [GOC:jl, ISBN:0198506732, PMID:20404130] |
| GO:0032991 | protein-containing complex | cellular_component | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. [GOC:dos, GOC:mah] |
| GO:0035064 | methylated histone binding | molecular_function | Binding to a histone in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. [GOC:bf, PMID:14585615] |
| GO:0005829 | cytosol | cellular_component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| GO:1902494 | catalytic complex | cellular_component | A protein complex which is capable of catalytic activity. [GOC:bhm, GOC:TermGenie, PMID:8077207] |
| GO:0043412 | macromolecule modification | biological_process | The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties. [GOC:go_curators] |
| GO:0044238 | primary metabolic process | biological_process | The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. [GOC:go_curators, http://www.metacyc.org] |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH] |
| GO:0065007 | biological regulation | biological_process | Any process that modulates a measurable attribute of any biological process, quality or function. [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] |
| GO:0048869 | cellular developmental process | biological_process | A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition. [GOC:isa_complete] |
| GO:0070603 | SWI/SNF superfamily-type complex | cellular_component | A protein complex that contains an ortholog of the Saccharomyces ATPase Swi2/Snf2 as one of the catalytic subunit components (ATPase) and mediates assembly of nucleosomes, changes to the spacing or structure of nucleosomes, or some combination of those activities in a manner that requires ATP. [GOC:bhm, GOC:krc, GOC:mah, PMID:16155938] |
| GO:0010647 | positive regulation of cell communication | biological_process | Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. [GOC:dph, GOC:tb] |
| GO:0071840 | cellular component organization or biogenesis | biological_process | A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component. [GOC:mah] |
| GO:1904949 | ATPase complex | cellular_component | A protein complex which is capable of ATPase activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:9606181] |
| GO:0032502 | developmental process | biological_process | A biological process whose specific outcome is the progression of an integrated living unit |
| GO:0023051 | regulation of signaling | biological_process | Any process that modulates the frequency, rate or extent of a signaling process. [GOC:mtg_signal] |
| GO:0043967 | histone H4 acetylation | biological_process | The modification of histone H4 by the addition of an acetyl group. [GOC:jl] |
| GO:0071704 | organic substance metabolic process | biological_process | The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon. [GOC:mah] |
| GO:0005488 | binding | molecular_function | The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. [GOC:ceb, GOC:mah, ISBN:0198506732] |
| GO:0018193 | peptidyl-amino acid modification | biological_process | The alteration of an amino acid residue in a peptide. [GOC:mah] |
| GO:0005634 | nucleus | cellular_component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| GO:0009967 | positive regulation of signal transduction | biological_process | Any process that activates or increases the frequency, rate or extent of signal transduction. [GOC:sm] |
| GO:0005515 | protein binding | molecular_function | Binding to a protein. [GOC:go_curators] |
| GO:0043414 | macromolecule methylation | biological_process | The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule. [GOC:go_curators] |
| GO:0006338 | chromatin remodeling | biological_process | Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation. [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820] |
| GO:0008152 | metabolic process | biological_process | The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. [GOC:go_curators, ISBN:0198547684] |
| GO:0030182 | neuron differentiation | biological_process | The process in which a relatively unspecialized cell acquires specialized features of a neuron. [GOC:mah] |
| GO:0018022 | peptidyl-lysine methylation | biological_process | The methylation of peptidyl-lysine to form either the mono-, di- or trimethylated derivative. [GOC:ai] |
| GO:1901564 | organonitrogen compound metabolic process | biological_process | The chemical reactions and pathways involving organonitrogen compound. [GOC:pr, GOC:TermGenie] |
| GO:0009987 | cellular process | biological_process | Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. [GOC:go_curators, GOC:isa_complete] |
| GO:0010646 | regulation of cell communication | biological_process | Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. [GOC:dph, GOC:tb] |
| GO:0003678 | DNA helicase activity | molecular_function | Unwinding of a DNA helix, driven by ATP hydrolysis. [EC:3.6.4.12, GOC:jl] |
| GO:0048584 | positive regulation of response to stimulus | biological_process | Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. [GOC:jid] |
| GO:0003824 | catalytic activity | molecular_function | Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. [GOC:vw, ISBN:0198506732] |
| GO:0048522 | positive regulation of cellular process | biological_process | Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. [GOC:jid] |
| GO:0006357 | regulation of transcription by RNA polymerase II | biological_process | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH] |
| GO:0043486 | histone exchange | biological_process | The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits. [GOC:jl, PMID:11735001, PMID:15066277] |
| GO:0021953 | central nervous system neuron differentiation | biological_process | The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] |
| GO:0034728 | nucleosome organization | biological_process | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of one or more nucleosomes. [GOC:mah] |
| GO:0034968 | histone lysine methylation | biological_process | The modification of a histone by addition of one or more methyl groups to a lysine residue. [GOC:mah, GOC:pr] |
| GO:0140097 | catalytic activity, acting on DNA | molecular_function | Catalytic activity that acts to modify DNA. [GOC:molecular_function_refactoring, GOC:pdt] |
| GO:0016020 | membrane | cellular_component | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| GO:0003677 | DNA binding | molecular_function | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). [GOC:dph, GOC:jl, GOC:tb, GOC:vw] |
| GO:0048583 | regulation of response to stimulus | biological_process | Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. [GOC:jid] |
| GO:0071824 | protein-DNA complex subunit organization | biological_process | Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex. [GOC:mah] |
| GO:0006464 | cellular protein modification process | biological_process | The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). [GOC:go_curators] |
| GO:0008094 | ATP-dependent activity, acting on DNA | molecular_function | Catalytic activity that acts to modify DNA, driven by ATP hydrolysis. [GOC:pdt] |
| GO:0022412 | cellular process involved in reproduction in multicellular organism | biological_process | A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism. [GOC:isa_complete] |
| GO:0006325 | chromatin organization | biological_process | Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin. [GOC:mah, GOC:vw, PMID:20404130] |
| GO:1902533 | positive regulation of intracellular signal transduction | biological_process | Any process that activates or increases the frequency, rate or extent of intracellular signal transduction. [GOC:BHF, GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] |
| GO:0032259 | methylation | biological_process | The process in which a methyl group is covalently attached to a molecule. [GOC:mah] |
| GO:0048518 | positive regulation of biological process | biological_process | Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. [GOC:jid] |
| GO:0036211 | protein modification process | biological_process | The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). [GOC:bf, GOC:jl] |
| GO:0044267 | cellular protein metabolic process | biological_process | The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification. [GOC:jl] |
| GO:0000785 | chromatin | cellular_component | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. [GOC:elh, PMID:20404130] |
| GO:0016043 | cellular component organization | biological_process | A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. [GOC:ai, GOC:jl, GOC:mah] |
| GO:0023056 | positive regulation of signaling | biological_process | Any process that activates, maintains or increases the frequency, rate or extent of a signaling process. [GOC:mtg_signal] |
| GO:0000792 | heterochromatin | cellular_component | A compact and highly condensed form of chromatin that is refractory to transcription. [PMID:32017156] |
| GO:0022414 | reproductive process | biological_process | A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents. [GOC:dph, GOC:isa_complete] |
| GO:0005667 | transcription regulator complex | cellular_component | A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription. [GOC:jl] |
| GO:0008213 | protein alkylation | biological_process | The addition of an alkyl group to a protein amino acid. Alkyl groups are derived from alkanes by removal of one hydrogen atom. [GOC:ma] |
| GO:0140030 | modification-dependent protein binding | molecular_function | Binding to a protein upon post-translation modification of the target protein. [PMID:26060076] |
| GO:0042393 | histone binding | molecular_function | Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity. [GOC:jl] |
| GO:0019538 | protein metabolic process | biological_process | The chemical reactions and pathways involving a protein. Includes protein modification. [GOC:ma] |
| GO:0016570 | histone modification | biological_process | The covalent alteration of one or more amino acid residues within a histone protein. [GOC:krc] |
| GO:0044260 | cellular macromolecule metabolic process | biological_process | The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells. [GOC:mah] |
| GO:0008285 | negative regulation of cell population proliferation | biological_process | Any process that stops, prevents or reduces the rate or extent of cell proliferation. [GOC:go_curators] |
| GO:0030154 | cell differentiation | biological_process | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. [ISBN:0198506732] |
| GO:0006807 | nitrogen compound metabolic process | biological_process | The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen. [GOC:jl, ISBN:0198506732] |
| GO:0050789 | regulation of biological process | biological_process | Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. [GOC:ai, GOC:go_curators] |
| GO:0044237 | cellular metabolic process | biological_process | The chemical reactions and pathways by which individual cells transform chemical substances. [GOC:go_curators] |
| GO:0006479 | protein methylation | biological_process | The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom. [GOC:ai] |
| GO:0032508 | DNA duplex unwinding | biological_process | The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands. [GOC:isa_complete, GOC:mah] |
| GO:0018205 | peptidyl-lysine modification | biological_process | The modification of peptidyl-lysine. [GOC:go_curators] |
| GO:0005524 | ATP binding | molecular_function | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732] |
| GO:0016887 | ATP hydrolysis activity | molecular_function | Catalysis of the reaction |
| GO:0000118 | histone deacetylase complex | cellular_component | A protein complex that possesses histone deacetylase activity. [GOC:mah] |
| GO:0043933 | protein-containing complex organization | biological_process | Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex. [GOC:mah] |
| GO:0050794 | regulation of cellular process | biological_process | Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. [GOC:go_curators] |
| GO:1902531 | regulation of intracellular signal transduction | biological_process | Any process that modulates the frequency, rate or extent of intracellular signal transduction. [GOC:dph, GOC:signaling, GOC:tb, GOC:TermGenie] |
| GO:0016571 | histone methylation | biological_process | The modification of histones by addition of methyl groups. [GOC:ai] |
| GO:0016607 | nuclear speck | cellular_component | A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. [http://www.cellnucleus.com/] |
| GO:0009966 | regulation of signal transduction | biological_process | Any process that modulates the frequency, rate or extent of signal transduction. [GOC:sm] |
| GO:0005654 | nucleoplasm | cellular_component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| GO:0046872 | metal ion binding | molecular_function | Binding to a metal ion. [GOC:ai] |
| GO:0043170 | macromolecule metabolic process | biological_process | The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. [GOC:mah] |