| GO term | GO name | GO namespace | GO def |
| GO:0043233 | organelle lumen | cellular_component | The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen. [GOC:jl, GOC:mah] |
| GO:0090174 | organelle membrane fusion | biological_process | The joining of two lipid bilayers to form a single organelle membrane. [GOC:ascb_2009, GOC:dph, GOC:tb] |
| GO:0036211 | protein modification process | biological_process | The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). [GOC:bf, GOC:jl] |
| GO:0031982 | vesicle | cellular_component | Any small, fluid-filled, spherical organelle enclosed by membrane. [GOC:mah, GOC:pz, GOC:vesicles] |
| GO:0016021 | integral component of membrane | cellular_component | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:dos, GOC:go_curators] |
| GO:0051336 | regulation of hydrolase activity | biological_process | Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. [GOC:ai] |
| GO:0046777 | protein autophosphorylation | biological_process | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). [ISBN:0198506732] |
| GO:0110165 | cellular anatomical entity | cellular_component | A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex. [GOC:kmv] |
| GO:1905037 | autophagosome organization | biological_process | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an autophagosome. [GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22186024] |
| GO:0005774 | vacuolar membrane | cellular_component | The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell. [GOC:ai] |
| GO:0098771 | inorganic ion homeostasis | biological_process | Any process involved in the maintenance of an internal steady state of inorganic ions within an organism or cell. [GOC:dos] |
| GO:1903530 | regulation of secretion by cell | biological_process | Any process that modulates the frequency, rate or extent of secretion by cell. [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:12130530] |
| GO:0050789 | regulation of biological process | biological_process | Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. [GOC:ai, GOC:go_curators] |
| GO:0005764 | lysosome | cellular_component | A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. [GOC:mah, ISBN:0198506732] |
| GO:0032880 | regulation of protein localization | biological_process | Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location. [GOC:dph, GOC:mah, GOC:tb] |
| GO:0051223 | regulation of protein transport | biological_process | Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai] |
| GO:0044087 | regulation of cellular component biogenesis | biological_process | Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. [GOC:jl] |
| GO:0051179 | localization | biological_process | Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation. [GOC:ai, GOC:dos] |
| GO:0043169 | cation binding | molecular_function | Binding to a cation, a charged atom or group of atoms with a net positive charge. [GOC:jl] |
| GO:0080090 | regulation of primary metabolic process | biological_process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. [PMID:19211694] |
| GO:0031974 | membrane-enclosed lumen | cellular_component | The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen. [GOC:add, GOC:mah] |
| GO:0071702 | organic substance transport | biological_process | The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon. [GOC:mah] |
| GO:0044267 | cellular protein metabolic process | biological_process | The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification. [GOC:jl] |
| GO:0017157 | regulation of exocytosis | biological_process | Any process that modulates the frequency, rate or extent of exocytosis. [GOC:go_curators] |
| GO:0055076 | transition metal ion homeostasis | biological_process | Any process involved in the maintenance of an internal steady state of transition metal ions within an organism or cell. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. [GOC:jid, GOC:mah, ISBN:0198506732] |
| GO:0052548 | regulation of endopeptidase activity | biological_process | Any process that modulates the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins. [GOC:ai, GOC:hjd] |
| GO:0008324 | cation transmembrane transporter activity | molecular_function | Enables the transfer of cation from one side of a membrane to the other. [GOC:dgf, GOC:mtg_transport, ISBN:0815340729] |
| GO:0016310 | phosphorylation | biological_process | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. [ISBN:0198506732] |
| GO:0006874 | cellular calcium ion homeostasis | biological_process | Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell. [GOC:ceb, GOC:mah] |
| GO:0032269 | negative regulation of cellular protein metabolic process | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell. [GOC:mah] |
| GO:0008270 | zinc ion binding | molecular_function | Binding to a zinc ion (Zn). [GOC:ai] |
| GO:0006996 | organelle organization | biological_process | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. [GOC:mah] |
| GO:0043412 | macromolecule modification | biological_process | The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties. [GOC:go_curators] |
| GO:0016020 | membrane | cellular_component | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| GO:0030162 | regulation of proteolysis | biological_process | Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. [GOC:mah] |
| GO:1903363 | negative regulation of cellular protein catabolic process | biological_process | Any process that stops, prevents or reduces the frequency, rate or extent of cellular protein catabolic process. [GO_REF:0000058, GOC:kmv, GOC:obol, GOC:TermGenie, PMID:24785082] |
| GO:0043231 | intracellular membrane-bounded organelle | cellular_component | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators] |
| GO:0048519 | negative regulation of biological process | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. [GOC:jid] |
| GO:0019538 | protein metabolic process | biological_process | The chemical reactions and pathways involving a protein. Includes protein modification. [GOC:ma] |
| GO:0016050 | vesicle organization | biological_process | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle. [GOC:mah] |
| GO:0070013 | intracellular organelle lumen | cellular_component | An organelle lumen that is part of an intracellular organelle. [GOC:mah] |
| GO:0031324 | negative regulation of cellular metabolic process | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. [GOC:mah] |
| GO:0031090 | organelle membrane | cellular_component | A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle. [GOC:dos, GOC:mah] |
| GO:0042592 | homeostatic process | biological_process | Any biological process involved in the maintenance of an internal steady state. [GOC:jl, ISBN:0395825172] |
| GO:0065008 | regulation of biological quality | biological_process | Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc. [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] |
| GO:0043167 | ion binding | molecular_function | Binding to an ion, a charged atoms or groups of atoms. [GOC:jl] |
| GO:0012506 | vesicle membrane | cellular_component | The lipid bilayer surrounding any membrane-bounded vesicle in the cell. [GOC:mah, GOC:vesicle] |
| GO:0006879 | cellular iron ion homeostasis | biological_process | Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell. [GOC:ai, GOC:mah] |
| GO:0031323 | regulation of cellular metabolic process | biological_process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. [GOC:mah] |
| GO:0031902 | late endosome membrane | cellular_component | The lipid bilayer surrounding a late endosome. [GOC:pz] |
| GO:0043168 | anion binding | molecular_function | Binding to an anion, a charged atom or group of atoms with a net negative charge. [GOC:jl] |
| GO:0005507 | copper ion binding | molecular_function | Binding to a copper (Cu) ion. [GOC:ai] |
| GO:0015318 | inorganic molecular entity transmembrane transporter activity | molecular_function | Enables the transfer of an inorganic molecular entity from the outside of a cell to the inside of the cell across a membrane. An inorganic molecular entity is a molecular entity that contains no carbon. [GOC:mtg_transport, ISBN:0815340729] |
| GO:0010008 | endosome membrane | cellular_component | The lipid bilayer surrounding an endosome. [GOC:mah] |
| GO:0042221 | response to chemical | biological_process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus. [GOC:jl] |
| GO:0034599 | cellular response to oxidative stress | biological_process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. [GOC:mah] |
| GO:0031300 | intrinsic component of organelle membrane | cellular_component | The component of the organelle membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. [GOC:dos, GOC:mah] |
| GO:0005768 | endosome | cellular_component | A vacuole to which materials ingested by endocytosis are delivered. [ISBN:0198506732, PMID:19696797] |
| GO:1903362 | regulation of cellular protein catabolic process | biological_process | Any process that modulates the frequency, rate or extent of cellular protein catabolic process. [GO_REF:0000058, GOC:kmv, GOC:obol, GOC:TermGenie, PMID:24785082] |
| GO:0043226 | organelle | cellular_component | Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane. [GOC:go_curators] |
| GO:0097708 | intracellular vesicle | cellular_component | Any vesicle that is part of the intracellular region. [GOC:vesicles] |
| GO:0048523 | negative regulation of cellular process | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. [GOC:jid] |
| GO:0008289 | lipid binding | molecular_function | Binding to a lipid. [GOC:ai] |
| GO:0065009 | regulation of molecular function | biological_process | Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. [GOC:isa_complete] |
| GO:0030003 | cellular cation homeostasis | biological_process | Any process involved in the maintenance of an internal steady state of cations at the level of a cell. [GOC:ceb, GOC:mah] |
| GO:0035091 | phosphatidylinositol binding | molecular_function | Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives. [GOC:bf, ISBN:0198506732, PMID:11395417] |
| GO:0045921 | positive regulation of exocytosis | biological_process | Any process that activates or increases the frequency, rate or extent of exocytosis. [GOC:go_curators] |
| GO:0010821 | regulation of mitochondrion organization | biological_process | Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion. [GOC:dph, GOC:tb] |
| GO:0044089 | positive regulation of cellular component biogenesis | biological_process | Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. [GOC:jl] |
| GO:0072507 | divalent inorganic cation homeostasis | biological_process | Any process involved in the maintenance of an internal steady state of divalent cations within an organism or cell. [GOC:mah] |
| GO:0018193 | peptidyl-amino acid modification | biological_process | The alteration of an amino acid residue in a peptide. [GOC:mah] |
| GO:0090066 | regulation of anatomical structure size | biological_process | Any process that modulates the size of an anatomical structure. [GOC:dph, GOC:tb] |
| GO:0010035 | response to inorganic substance | biological_process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus. [GOC:sm] |
| GO:0052547 | regulation of peptidase activity | biological_process | Any process that modulates the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins. [GOC:ai] |
| GO:0009892 | negative regulation of metabolic process | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. [GOC:go_curators] |
| GO:0031329 | regulation of cellular catabolic process | biological_process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. [GOC:mah] |
| GO:0061025 | membrane fusion | biological_process | The membrane organization process that joins two lipid bilayers to form a single membrane. [GOC:dph, GOC:tb] |
| GO:0022890 | inorganic cation transmembrane transporter activity | molecular_function | Enables the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage. [GOC:ai, GOC:mtg_transport, ISBN:0815340729] |
| GO:0016887 | ATP hydrolysis activity | molecular_function | Catalysis of the reaction |
| GO:0005515 | protein binding | molecular_function | Binding to a protein. [GOC:go_curators] |
| GO:0071705 | nitrogen compound transport | biological_process | The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah] |
| GO:0060341 | regulation of cellular localization | biological_process | Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell. [GOC:dph, GOC:tb] |
| GO:0044085 | cellular component biogenesis | biological_process | A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component. [GOC:jl, GOC:mah] |
| GO:0051171 | regulation of nitrogen compound metabolic process | biological_process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. [GOC:ai, GOC:tb] |
| GO:0030659 | cytoplasmic vesicle membrane | cellular_component | The lipid bilayer surrounding a cytoplasmic vesicle. [GOC:mah] |
| GO:0042176 | regulation of protein catabolic process | biological_process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. [GOC:go_curators, GOC:jl] |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. [GOC:ai, GOC:tb] |
| GO:0043229 | intracellular organelle | cellular_component | Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. [GOC:go_curators] |
| GO:0098588 | bounding membrane of organelle | cellular_component | The lipid bilayer that forms the outer-most layer of an organelle. [GOC:dos] |
| GO:0051246 | regulation of protein metabolic process | biological_process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. [GOC:ai] |
| GO:0070887 | cellular response to chemical stimulus | biological_process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus. [GOC:mah] |
| GO:1902936 | phosphatidylinositol bisphosphate binding | molecular_function | Binding to phosphatidylinositol bisphosphate. [GO_REF:0000067, GOC:bhm, GOC:TermGenie, PMID:18690034] |
| GO:0005765 | lysosomal membrane | cellular_component | The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. [GOC:ai] |
| GO:0010038 | response to metal ion | biological_process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus. [GOC:sm] |
| GO:0006812 | cation transport | biological_process | The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai] |
| GO:0010605 | negative regulation of macromolecule metabolic process | biological_process | Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. [GOC:dph, GOC:tb] |
| GO:0048522 | positive regulation of cellular process | biological_process | Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. [GOC:jid] |
| GO:0010628 | positive regulation of gene expression | biological_process | Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018] |
| GO:0061462 | protein localization to lysosome | biological_process | A process in which a protein is transported to, or maintained in, a location within a lysosome. [GOC:dph] |
| GO:0051234 | establishment of localization | biological_process | Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. [GOC:ai, GOC:dos] |
| GO:0060255 | regulation of macromolecule metabolic process | biological_process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. [GOC:dph, GOC:tb] |
| GO:0051248 | negative regulation of protein metabolic process | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein. [GOC:ai] |
| GO:0055085 | transmembrane transport | biological_process | The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:dph, GOC:jid] |
| GO:0005543 | phospholipid binding | molecular_function | Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester. [ISBN:0198506732] |
| GO:0050794 | regulation of cellular process | biological_process | Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. [GOC:go_curators] |
| GO:0007033 | vacuole organization | biological_process | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole. [GOC:mah] |
| GO:0022853 | active ion transmembrane transporter activity | molecular_function | Enables the transfer of an ion from one side of a membrane to the other up the solute's concentration gradient. This is carried out by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction. [GOC:mtg_transport, ISBN:0815340729] |
| GO:0043005 | neuron projection | cellular_component | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. [GOC:jl, http://www.cogsci.princeton.edu/~wn/] |
| GO:0046872 | metal ion binding | molecular_function | Binding to a metal ion. [GOC:ai] |
| GO:0006811 | ion transport | biological_process | The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai] |
| GO:0061024 | membrane organization | biological_process | A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. [GOC:dph, GOC:tb] |
| GO:0006810 | transport | biological_process | The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter, pore or motor protein. [GOC:dos, GOC:dph, GOC:jl, GOC:mah] |
| GO:0030133 | transport vesicle | cellular_component | Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell. [GOC:mah, PMID:22160157] |
| GO:1903532 | positive regulation of secretion by cell | biological_process | Any process that activates or increases the frequency, rate or extent of secretion by cell. [GO_REF:0000058, GOC:pm, GOC:TermGenie, PMID:12130530] |
| GO:0051047 | positive regulation of secretion | biological_process | Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. [GOC:ai] |
| GO:0022804 | active transmembrane transporter activity | molecular_function | Enables the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction. [GOC:mtg_transport, ISBN:0815340729] |
| GO:0051716 | cellular response to stimulus | biological_process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell. [GOC:bf, GOC:jl] |
| GO:0043025 | neuronal cell body | cellular_component | The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. [GOC:go_curators] |
| GO:1901981 | phosphatidylinositol phosphate binding | molecular_function | Binding to phosphatidylinositol phosphate. [GOC:TermGenie, PMID:23445487] |
| GO:0006906 | vesicle fusion | biological_process | Fusion of the membrane of a transport vesicle with its target membrane. [GOC:jid] |
| GO:1901564 | organonitrogen compound metabolic process | biological_process | The chemical reactions and pathways involving organonitrogen compound. [GOC:pr, GOC:TermGenie] |
| GO:0050790 | regulation of catalytic activity | biological_process | Any process that modulates the activity of an enzyme. [GOC:ai, GOC:ebc, GOC:vw] |
| GO:0050801 | ion homeostasis | biological_process | Any process involved in the maintenance of an internal steady state of ions within an organism or cell. [GOC:ai] |
| GO:0051046 | regulation of secretion | biological_process | Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. [GOC:ai] |
| GO:0016241 | regulation of macroautophagy | biological_process | Any process that modulates the frequency, rate or extent of macroautophagy. [GOC:krc] |
| GO:0016043 | cellular component organization | biological_process | A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. [GOC:ai, GOC:jl, GOC:mah] |
| GO:0055065 | metal ion homeostasis | biological_process | Any process involved in the maintenance of an internal steady state of metal ions within an organism or cell. [GOC:ai, GOC:jid, GOC:mah] |
| GO:0007041 | lysosomal transport | biological_process | The directed movement of substances into, out of or within a lysosome. [GOC:ai] |
| GO:0046914 | transition metal ion binding | molecular_function | Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. [ISBN:0198506732] |
| GO:0031410 | cytoplasmic vesicle | cellular_component | A vesicle found in the cytoplasm of a cell. [GOC:ai, GOC:mah, GOC:vesicles] |
| GO:0005215 | transporter activity | molecular_function | Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells. [GOC:ai, GOC:dgf] |
| GO:0043227 | membrane-bounded organelle | cellular_component | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators] |
| GO:0009894 | regulation of catabolic process | biological_process | Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances. [GOC:go_curators] |
| GO:0048518 | positive regulation of biological process | biological_process | Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. [GOC:jid] |
| GO:0050714 | positive regulation of protein secretion | biological_process | Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell. [GOC:ai] |
| GO:1901215 | negative regulation of neuron death | biological_process | Any process that stops, prevents or reduces the frequency, rate or extent of neuron death. [GOC:rph, GOC:TermGenie] |
| GO:0005488 | binding | molecular_function | The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. [GOC:ceb, GOC:mah, ISBN:0198506732] |
| GO:0042177 | negative regulation of protein catabolic process | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. [GOC:go_curators, GOC:jl, PMID:10207076] |
| GO:0006793 | phosphorus metabolic process | biological_process | The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus, usually in the form of a phosphate group (PO4). [GOC:ai] |
| GO:0032268 | regulation of cellular protein metabolic process | biological_process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell. [GOC:mah] |
| GO:0034220 | ion transmembrane transport | biological_process | A process in which an ion is transported across a membrane. [GOC:mah] |
| GO:0051050 | positive regulation of transport | biological_process | Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai] |
| GO:0032535 | regulation of cellular component size | biological_process | A process that modulates the size of a cellular component. [GOC:mah] |
| GO:0044237 | cellular metabolic process | biological_process | The chemical reactions and pathways by which individual cells transform chemical substances. [GOC:go_curators] |
| GO:0044238 | primary metabolic process | biological_process | The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. [GOC:go_curators, http://www.metacyc.org] |
| GO:0006807 | nitrogen compound metabolic process | biological_process | The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen. [GOC:jl, ISBN:0198506732] |
| GO:0060627 | regulation of vesicle-mediated transport | biological_process | Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell. [GOC:dph, GOC:tb] |
| GO:0006796 | phosphate-containing compound metabolic process | biological_process | The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. [GOC:ai] |
| GO:0010506 | regulation of autophagy | biological_process | Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. [GOC:dph, GOC:tb] |
| GO:0055080 | cation homeostasis | biological_process | Any process involved in the maintenance of an internal steady state of cations within an organism or cell. [GOC:ceb, GOC:jid, GOC:mah] |
| GO:0051128 | regulation of cellular component organization | biological_process | Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. [GOC:ai] |
| GO:0050896 | response to stimulus | biological_process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. [GOC:ai, GOC:bf] |
| GO:0006464 | cellular protein modification process | biological_process | The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). [GOC:go_curators] |
| GO:0051049 | regulation of transport | biological_process | Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai] |
| GO:0044260 | cellular macromolecule metabolic process | biological_process | The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells. [GOC:mah] |
| GO:0005776 | autophagosome | cellular_component | A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy. [GOC:autophagy, ISBN:0198547684, PMID:11099404] |
| GO:0070201 | regulation of establishment of protein localization | biological_process | Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location. [GOC:BHF, GOC:mah] |
| GO:0048878 | chemical homeostasis | biological_process | Any biological process involved in the maintenance of an internal steady state of a chemical. [GOC:isa_complete] |
| GO:0005770 | late endosome | cellular_component | A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062] |
| GO:0019222 | regulation of metabolic process | biological_process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. [GOC:go_curators] |
| GO:0071840 | cellular component organization or biogenesis | biological_process | A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component. [GOC:mah] |
| GO:0033043 | regulation of organelle organization | biological_process | Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. [GOC:mah] |
| GO:0071704 | organic substance metabolic process | biological_process | The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon. [GOC:mah] |
| GO:0022857 | transmembrane transporter activity | molecular_function | Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. [GOC:jid, GOC:mtg_transport, ISBN:0815340729] |
| GO:0008152 | metabolic process | biological_process | The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. [GOC:go_curators, ISBN:0198547684] |
| GO:0065007 | biological regulation | biological_process | Any process that modulates a measurable attribute of any biological process, quality or function. [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] |
| GO:0006914 | autophagy | biological_process | The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation. [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464] |
| GO:0009895 | negative regulation of catabolic process | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. [GOC:go_curators] |
| GO:0009987 | cellular process | biological_process | Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. [GOC:go_curators, GOC:isa_complete] |
| GO:0043170 | macromolecule metabolic process | biological_process | The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. [GOC:mah] |
| GO:0055088 | lipid homeostasis | biological_process | Any process involved in the maintenance of an internal steady state of lipid within an organism or cell. [GOC:BHF, GOC:rl] |
| GO:0031224 | intrinsic component of membrane | cellular_component | The component of a membrane consisting of the gene products having some covalently attached portion, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, which spans or is embedded in one or both leaflets of the membrane. [GOC:mah] |
| GO:0006468 | protein phosphorylation | biological_process | The process of introducing a phosphate group on to a protein. [GOC:hb] |
| GO:0031330 | negative regulation of cellular catabolic process | biological_process | Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. [GOC:mah] |
| GO:0098655 | cation transmembrane transport | biological_process | The process in which a cation is transported across a membrane. [GOC:dos, GOC:vw] |
| GO:0006882 | cellular zinc ion homeostasis | biological_process | Any process involved in the maintenance of an internal steady state of zinc ions at the level of a cell. [GOC:ai, GOC:mah] |
| GO:0032879 | regulation of localization | biological_process | Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location. [GOC:mah] |
| GO:0005524 | ATP binding | molecular_function | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732] |
| GO:0048284 | organelle fusion | biological_process | The creation of a single organelle from two or more organelles. [GOC:jid] |
| GO:0031301 | integral component of organelle membrane | cellular_component | The component of the organelle membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:dos, GOC:mah] |
| GO:0015075 | ion transmembrane transporter activity | molecular_function | Enables the transfer of an ion from one side of a membrane to the other. [GOC:dgf, GOC:mtg_transport, ISBN:0815340729] |