Identifier |
UniProt Gene |
UniProt Accession |
UniProt Name |
Chromosome |
Cancer Database |
Cancer Driver |
Number of independent pubication |
Interaction Database |
Number of missense mutations |
Number of disordered residues |
Number of mutations in disordered residues |
Number of mutations in disordered residues |
Number of omim mutations |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ANOS1 | ANOS1 | P23352 | Anosmin-1 | chrX | Not Cancer Driver | No | 1 | hippie | 124 | 195 | 44 | 44 | 14 |
BIRC3_ENST00000532808 | BIRC3 | Q13489 | Baculoviral IAP repeat-containing protein 3 | chr11 | Census, Compendium | Yes | 1 | hippie | 77 | 98 | 16 | 16 | 0 |
BRD4 | BRD4 | O60885 | Bromodomain-containing protein 4 | chr19 | Census, Compendium | Yes | 1 | hippie | 193 | 1182 | 172 | 172 | 0 |
BYSL | BYSL | Q13895 | Bystin | chr6 | Not Cancer Driver | No | 1 | hippie, biogrid | 38 | 176 | 14 | 14 | 0 |
CBX3_ENST00000396386 | CBX3 | Q13185 | Chromobox protein homolog 3 | chr7 | Not Cancer Driver | No | 1 | hippie, biogrid | 23 | 119 | 18 | 18 | 0 |
CBX6 | CBX6 | O95503 | Chromobox protein homolog 6 | chr22 | Not Cancer Driver | No | 1 | hippie, biogrid | 57 | 335 | 54 | 54 | 0 |
CCAR2 | CCAR2 | Q8N163 | Cell cycle and apoptosis regulator protein 2 | chr8 | Not Cancer Driver | No | 1 | hippie | 102 | 528 | 62 | 62 | 0 |
CCNF | CCNF | P41002 | Cyclin-F | chr16 | Not Cancer Driver | No | 1 | hippie, biogrid | 106 | 221 | 23 | 23 | 3 |
CD274 | CD274 | Q9NZQ7 | Programmed cell death 1 ligand 1 | chr9 | Census | Yes | 1 | hippie | 29 | 54 | 9 | 9 | 0 |
CDC34 | CDC34 | P49427 | Ubiquitin-conjugating enzyme E2 R1 | chr19 | Not Cancer Driver | No | 1 | hippie | 26 | 95 | 11 | 11 | 0 |
CEP164 | CEP164 | Q9UPV0 | Centrosomal protein of 164 kDa | chr11 | Not Cancer Driver | No | 1 | intact, hippie | 161 | 1198 | 124 | 124 | 2 |
CHCHD1 | CHCHD1 | Q96BP2 | Coiled-coil-helix-coiled-coil-helix domain-containing protein 1 | chr10 | Not Cancer Driver | No | 1 | hippie, biogrid | 11 | 67 | 8 | 8 | 0 |
CHD3_ENST00000330494 | CHD3 | Q12873 | Chromodomain-helicase-DNA-binding protein 3 | chr17 | Not Cancer Driver | No | 1 | hippie | 235 | 1015 | 122 | 122 | 18 |
CHD4 | CHD4 | Q14839 | Chromodomain-helicase-DNA-binding protein 4 | chr12 | Census, Compendium | Yes | 1 | hippie | 419 | 974 | 177 | 177 | 6 |
CHMP4B | CHMP4B | Q9H444 | Charged multivesicular body protein 4b | chr20 | Not Cancer Driver | No | 1 | hippie | 25 | 201 | 22 | 22 | 2 |
CHMP4C | CHMP4C | Q96CF2 | Charged multivesicular body protein 4c | chr8 | Not Cancer Driver | No | 1 | hippie | 33 | 224 | 31 | 31 | 0 |
CIT_ENST00000261833 | CIT | O14578 | Citron Rho-interacting kinase | chr12 | Not Cancer Driver | No | 1 | hippie | 284 | 1017 | 160 | 160 | 3 |
COIL | COIL | P38432 | Coilin | chr17 | Not Cancer Driver | No | 1 | hippie, biogrid | 61 | 385 | 42 | 42 | 0 |
CUL7_ENST00000265348 | CUL7 | Q14999 | Cullin-7 | chr6 | Not Cancer Driver | No | 1 | hippie | 188 | 372 | 41 | 41 | 3 |
DDRGK1 | DDRGK1 | Q96HY6 | DDRGK domain-containing protein 1 | chr20 | Not Cancer Driver | No | 1 | hippie | 34 | 181 | 23 | 23 | 0 |
DDX18 | DDX18 | Q9NVP1 | ATP-dependent RNA helicase DDX18 | chr2 | Not Cancer Driver | No | 1 | hippie, biogrid | 111 | 239 | 36 | 36 | 0 |
DDX60 | DDX60 | Q8IY21 | Probable ATP-dependent RNA helicase DDX60 | chr4 | Not Cancer Driver | No | 1 | intact, hippie | 224 | 131 | 12 | 12 | 0 |
DNAJB6 | DNAJB6 | O75190 | DnaJ homolog subfamily B member 6 | chr7 | Not Cancer Driver | No | 1 | hippie, biogrid | 33 | 198 | 17 | 17 | 3 |
DNAJC17 | DNAJC17 | Q9NVM6 | DnaJ homolog subfamily C member 17 | chr15 | Not Cancer Driver | No | 1 | hippie, biogrid | 39 | 209 | 28 | 28 | 0 |
DNAJC8 | DNAJC8 | O75937 | DnaJ homolog subfamily C member 8 | chr1 | Not Cancer Driver | No | 1 | hippie, biogrid | 29 | 188 | 23 | 23 | 0 |
DNAJC9 | DNAJC9 | Q8WXX5 | DnaJ homolog subfamily C member 9 | chr10 | Not Cancer Driver | No | 1 | hippie, biogrid | 28 | 126 | 15 | 15 | 0 |
EED_ENST00000263360 | EED | O75530 | Polycomb protein EED | chr11 | Census | Yes | 1 | hippie | 64 | 79 | 11 | 11 | 6 |
ENO4 | ENO4 | A6NNW6 | Enolase 4 | chr10 | Not Cancer Driver | No | 1 | hippie | 13 | 197 | 4 | 4 | 0 |
ESR1_ENST00000206249 | ESR1 | P03372 | Estrogen receptor | chr6 | Census, Compendium | Yes | 1 | intact, hippie | 121 | 195 | 27 | 27 | 2 |
ESR2 | ESR2 | Q92731 | Estrogen receptor beta | chr14 | Not Cancer Driver | No | 1 | hippie | 90 | 92 | 11 | 11 | 1 |
EXOSC10 | EXOSC10 | Q01780 | Exosome component 10 | chr1 | Not Cancer Driver | No | 1 | hippie | 87 | 375 | 35 | 35 | 0 |
EXOSC4 | EXOSC4 | Q9NPD3 | Exosome complex component RRP41 | chr8 | Not Cancer Driver | No | 1 | hippie, biogrid | 34 | 23 | 0 | 0 | 0 |
EXOSC5 | EXOSC5 | Q9NQT4 | Exosome complex component RRP46 | chr19 | Not Cancer Driver | No | 1 | intact, hippie | 43 | 31 | 3 | 3 | 0 |
FBL | FBL | P22087 | rRNA 2'-O-methyltransferase fibrillarin | chr19 | Not Cancer Driver | No | 2 | intact, hippie, biogrid | 46 | 145 | 22 | 22 | 0 |
FBXO32 | FBXO32 | Q969P5 | F-box only protein 32 | chr8 | Not Cancer Driver | No | 1 | hippie | 54 | 0 | 0 | 0 | 0 |
FGF8_ENST00000344255 | FGF8 | P55075 | Fibroblast growth factor 8 | chr10 | Not Cancer Driver | No | 2 | hippie, biogrid | 30 | 79 | 9 | 9 | 6 |
G3BP1 | G3BP1 | Q13283 | Ras GTPase-activating protein-binding protein 1 | chr5 | Not Cancer Driver | No | 1 | intact | 85 | 352 | 65 | 65 | 0 |
GATA4_ENST00000335135 | GATA4 | P43694 | Transcription factor GATA-4 | chr8 | Not Cancer Driver | No | 1 | hippie | 48 | 301 | 34 | 34 | 18 |
GRSF1 | GRSF1 | Q12849 | G-rich sequence factor 1 | chr4 | Not Cancer Driver | No | 1 | hippie, biogrid | 49 | 147 | 20 | 20 | 0 |
GTPBP4 | GTPBP4 | Q9BZE4 | GTP-binding protein 4 | chr10 | Not Cancer Driver | No | 1 | hippie, biogrid | 79 | 232 | 34 | 34 | 0 |
HNRNPU | HNRNPU | Q00839 | Heterogeneous nuclear ribonucleoprotein U | chr1 | Not Cancer Driver | No | 1 | intact, hippie | 77 | 504 | 45 | 45 | 0 |
IFI16_ENST00000295809 | IFI16 | Q16666 | Gamma-interferon-inducible protein 16 | chr1 | Not Cancer Driver | No | 1 | hippie | 155 | 419 | 90 | 90 | 0 |
ILF3_ENST00000590261 | ILF3 | Q12906 | Interleukin enhancer-binding factor 3 | chr19 | Not Cancer Driver | No | 1 | hippie, biogrid | 103 | 674 | 82 | 82 | 0 |
IQGAP1 | IQGAP1 | P46940 | Ras GTPase-activating-like protein IQGAP1 | chr15 | Not Cancer Driver | No | 1 | hippie, biogrid | 183 | 351 | 35 | 35 | 0 |
JUN | JUN | P05412 | Transcription factor Jun | chr1 | Census | Yes | 1 | hippie | 35 | 281 | 25 | 25 | 0 |
KIF14 | KIF14 | Q15058 | Kinesin-like protein KIF14 | chr1 | Not Cancer Driver | No | 1 | hippie | 222 | 774 | 102 | 102 | 2 |
KIF20A | KIF20A | O95235 | Kinesin-like protein KIF20A | chr5 | Not Cancer Driver | No | 1 | hippie | 79 | 340 | 40 | 40 | 1 |
KIF23 | KIF23 | Q02241 | Kinesin-like protein KIF23 | chr15 | Not Cancer Driver | No | 1 | hippie | 102 | 559 | 62 | 62 | 0 |
KLHL20 | KLHL20 | Q9Y2M5 | Kelch-like protein 20 | chr1 | Not Cancer Driver | No | 1 | hippie, biogrid | 83 | 143 | 17 | 17 | 0 |
MAP1LC3B | MAP1LC3B | Q9GZQ8 | Microtubule-associated proteins 1A/1B light chain 3B | chr16 | Not Cancer Driver | No | 1 | hippie | 10 | 17 | 1 | 1 | 0 |
MKI67 | MKI67 | P46013 | Proliferation marker protein Ki-67 | chr10 | Not Cancer Driver | No | 1 | intact, hippie, biogrid | 540 | 3169 | 529 | 529 | 0 |
MNDA | MNDA | P41218 | Myeloid cell nuclear differentiation antigen | chr1 | Not Cancer Driver | No | 1 | intact, hippie, biogrid | 180 | 172 | 76 | 76 | 0 |
MPHOSPH6 | MPHOSPH6 | Q99547 | M-phase phosphoprotein 6 | chr16 | Not Cancer Driver | No | 1 | hippie, biogrid | 19 | 68 | 8 | 8 | 0 |
MYC_ENST00000377970 | MYC | P01106 | Myc proto-oncogene protein | chr8 | Census, Compendium | Yes | 1 | hippie | 80 | 299 | 46 | 46 | 0 |
NIFK | NIFK | Q9BYG3 | MKI67 FHA domain-interacting nucleolar phosphoprotein | chr2 | Not Cancer Driver | No | 1 | hippie, biogrid | 32 | 148 | 15 | 15 | 0 |
NIN | NIN | Q8N4C6 | Ninein | chr14 | Census, Compendium | Yes | 1 | hippie | 239 | 1392 | 164 | 164 | 2 |
NOP56 | NOP56 | O00567 | Nucleolar protein 56 | chr20 | Not Cancer Driver | No | 2 | intact, hippie, biogrid | 83 | 191 | 34 | 34 | 0 |
NOP58 | NOP58 | Q9Y2X3 | Nucleolar protein 58 | chr2 | Not Cancer Driver | No | 1 | hippie | 47 | 156 | 14 | 14 | 0 |
NPM1 | NPM1 | P06748 | Nucleophosmin | chr5 | Census, Compendium | Yes | 1 | hippie, biogrid | 29 | 249 | 22 | 22 | 0 |
NR2C2_ENST00000393102 | NR2C2 | P49116 | Nuclear receptor subfamily 2 group C member 2 | chr3 | Not Cancer Driver | No | 1 | hippie | 62 | 186 | 24 | 24 | 0 |
NSUN5_ENST00000252594 | NSUN5 | Q96P11 | 28S rRNA (cytosine-C(5))-methyltransferase | chr7 | Not Cancer Driver | No | 1 | hippie, biogrid | 52 | 47 | 7 | 7 | 0 |
NUP50 | NUP50 | Q9UKX7 | Nuclear pore complex protein Nup50 | chr22 | Not Cancer Driver | No | 1 | hippie, biogrid | 58 | 333 | 40 | 40 | 0 |
NUPR1_ENST00000324873 | NUPR1 | O60356 | Nuclear protein 1 | chr16 | Not Cancer Driver | No | 1 | hippie | 10 | 82 | 10 | 10 | 0 |
OBSL1 | OBSL1 | O75147 | Obscurin-like protein 1 | chr2 | Not Cancer Driver | No | 1 | hippie | 233 | 553 | 60 | 60 | 0 |
OXSR1 | OXSR1 | O95747 | Serine/threonine-protein kinase OSR1 | chr3 | Not Cancer Driver | No | 1 | hippie | 69 | 208 | 29 | 29 | 0 |
PDE10A_ENST00000366882 | PDE10A | Q9Y233 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | chr6 | Not Cancer Driver | No | 1 | intact, hippie | 198 | 79 | 21 | 21 | 4 |
PLEKHA4 | PLEKHA4 | Q9H4M7 | Pleckstrin homology domain-containing family A member 4 | chr19 | Not Cancer Driver | No | 1 | hippie | 136 | 687 | 128 | 128 | 0 |
PNO1 | PNO1 | Q9NRX1 | RNA-binding protein PNO1 | chr2 | Not Cancer Driver | No | 1 | hippie, biogrid | 30 | 85 | 10 | 10 | 0 |
POLR1E | POLR1E | Q9GZS1 | DNA-directed RNA polymerase I subunit RPA49 | chr9 | Not Cancer Driver | No | 1 | hippie, biogrid | 39 | 85 | 6 | 6 | 0 |
PRC1 | PRC1 | O43663 | Protein regulator of cytokinesis 1 | chr15 | Not Cancer Driver | No | 1 | hippie | 63 | 235 | 26 | 26 | 0 |
PUS1 | PUS1 | Q9Y606 | Pseudouridylate synthase 1 homolog | chr12 | Not Cancer Driver | No | 1 | hippie, biogrid | 48 | 157 | 18 | 18 | 1 |
PWP2 | PWP2 | Q15269 | Periodic tryptophan protein 2 homolog | chr21 | Not Cancer Driver | No | 2 | hippie, biogrid | 99 | 101 | 9 | 9 | 0 |
RBM4B_ENST00000310046 | RBM4B | Q9BQ04 | RNA-binding protein 4B | chr11 | Not Cancer Driver | No | 1 | hippie, biogrid | 47 | 126 | 19 | 19 | 0 |
RBM4_ENST00000310092 | RBM4 | Q9BWF3 | RNA-binding protein 4 | chr11 | Not Cancer Driver | No | 2 | intact, hippie, biogrid | 40 | 129 | 12 | 12 | 0 |
RC3H2_ENST00000357244 | RC3H2 | Q9HBD1 | Roquin-2 | chr9 | Not Cancer Driver | No | 1 | hippie | 128 | 703 | 81 | 81 | 0 |
RNF4 | RNF4 | P78317 | E3 ubiquitin-protein ligase RNF4 | chr4 | Not Cancer Driver | No | 1 | hippie | 14 | 117 | 7 | 7 | 0 |
RPA1 | RPA1 | P27694 | Replication protein A 70 kDa DNA-binding subunit | chr17 | Not Cancer Driver | No | 1 | hippie | 51 | 98 | 6 | 6 | 0 |
RPA2_ENST00000373912 | RPA2 | P15927 | Replication protein A 32 kDa subunit | chr1 | Not Cancer Driver | No | 1 | hippie | 28 | 114 | 16 | 16 | 0 |
RPA3 | RPA3 | P35244 | Replication protein A 14 kDa subunit | chr7 | Not Cancer Driver | No | 1 | hippie | 13 | 4 | 1 | 1 | 0 |
RPL26L1 | RPL26L1 | Q9UNX3 | 60S ribosomal protein L26-like 1 | chr5 | Not Cancer Driver | No | 1 | hippie, biogrid | 21 | 107 | 11 | 11 | 0 |
RPL27A | RPL27A | P46776 | 60S ribosomal protein L27a | chr11 | Not Cancer Driver | No | 1 | hippie, biogrid | 7 | 56 | 2 | 2 | 0 |
RPL31_ENST00000264258 | RPL31 | P62899 | 60S ribosomal protein L31 | chr2 | Not Cancer Driver | No | 1 | hippie, biogrid | 19 | 69 | 14 | 14 | 0 |
RPL35A | RPL35A | P18077 | 60S ribosomal protein L35a | chr3 | Not Cancer Driver | No | 1 | hippie, biogrid | 9 | 25 | 0 | 0 | 1 |
RPL4 | RPL4 | P36578 | 60S ribosomal protein L4 | chr15 | Not Cancer Driver | No | 1 | hippie, biogrid | 49 | 222 | 31 | 31 | 0 |
RPS24_ENST00000613865 | RPS24 | P62847 | 40S ribosomal protein S24 | chr10 | Not Cancer Driver | No | 1 | hippie, biogrid | 13 | 88 | 10 | 10 | 0 |
RPS6 | RPS6 | P62753 | 40S ribosomal protein S6 | chr9 | Not Cancer Driver | No | 2 | intact, hippie, biogrid | 38 | 150 | 25 | 25 | 0 |
RRP1B | RRP1B | Q14684 | Ribosomal RNA processing protein 1 homolog B | chr21 | Not Cancer Driver | No | 1 | intact, hippie | 74 | 513 | 48 | 48 | 0 |
RRP8 | RRP8 | O43159 | Ribosomal RNA-processing protein 8 | chr11 | Not Cancer Driver | No | 2 | intact, hippie, biogrid | 66 | 270 | 44 | 44 | 0 |
RRP9 | RRP9 | O43818 | U3 small nucleolar RNA-interacting protein 2 | chr3 | Not Cancer Driver | No | 1 | hippie, biogrid | 53 | 146 | 9 | 9 | 0 |
RTN1 | RTN1 | Q16799 | Reticulon-1 | chr14 | Not Cancer Driver | No | 1 | hippie, biogrid | 177 | 573 | 134 | 134 | 0 |
SIRT6 | SIRT6 | Q8N6T7 | NAD-dependent protein deacylase sirtuin-6 | chr19 | Not Cancer Driver | No | 1 | hippie | 33 | 164 | 12 | 12 | 0 |
SIRT7 | SIRT7 | Q9NRC8 | NAD-dependent protein deacetylase sirtuin-7 | chr17 | Not Cancer Driver | No | 1 | hippie | 48 | 163 | 15 | 15 | 0 |
SNIP1 | SNIP1 | Q8TAD8 | Smad nuclear-interacting protein 1 | chr1 | Not Cancer Driver | No | 1 | hippie | 58 | 285 | 40 | 40 | 1 |
SOX2 | SOX2 | P48431 | Transcription factor SOX-2 | chr3 | Census | Yes | 1 | intact, hippie | 39 | 312 | 39 | 39 | 0 |
SPDYE4 | SPDYE4 | A6NLX3 | Speedy protein E4 | chr17 | Not Cancer Driver | No | 1 | intact, hippie | 42 | 79 | 12 | 12 | 0 |
STAU1 | STAU1 | O95793 | Double-stranded RNA-binding protein Staufen homolog 1 | chr20 | Not Cancer Driver | No | 1 | hippie | 77 | 456 | 63 | 63 | 0 |
SUMO2 | SUMO2 | P61956 | Small ubiquitin-related modifier 2 | chr17 | Not Cancer Driver | No | 1 | hippie | 9 | 69 | 6 | 6 | 0 |
SURF6 | SURF6 | O75683 | Surfeit locus protein 6 | chr9 | Not Cancer Driver | No | 1 | hippie, biogrid | 58 | 337 | 56 | 56 | 0 |
TBL3 | TBL3 | Q12788 | Transducin beta-like protein 3 | chr16 | Not Cancer Driver | No | 1 | hippie, biogrid | 82 | 48 | 8 | 8 | 0 |
TCF7L2_ENST00000355995 | TCF7L2 | Q9NQB0 | Transcription factor 7-like 2 | chr10 | Census, Compendium | Yes | 1 | intact, hippie | 122 | 516 | 93 | 93 | 0 |
TECTB | TECTB | Q96PL2 | Beta-tectorin | chr10 | Not Cancer Driver | No | 1 | hippie, biogrid | 53 | 2 | 1 | 1 | 0 |
TEK | TEK | Q02763 | Angiopoietin-1 receptor | chr9 | Not Cancer Driver | No | 1 | intact | 219 | 126 | 22 | 22 | 10 |
TJP1_ENST00000346128 | TJP1 | Q07157 | Tight junction protein ZO-1 | chr15 | Not Cancer Driver | No | 1 | hippie, biogrid | 198 | 1350 | 151 | 151 | 0 |
TMEM206_ENST00000261455 | PACC1 | Q9H813 | Proton-activated chloride channel | chr1 | Not Cancer Driver | No | 1 | intact | 51 | 32 | 5 | 5 | 0 |
TP53_ENST00000445888 | TP53 | P04637 | Cellular tumor antigen p53 | chr17 | Census, Compendium | Yes | 1 | hippie | 2891 | 282 | 1466 | 1466 | 83 |
TRIM25 | TRIM25 | Q14258 | E3 ubiquitin/ISG15 ligase TRIM25 | chr17 | Not Cancer Driver | No | 1 | hippie | 59 | 225 | 20 | 20 | 0 |
TSSK4_ENST00000287913 | TSSK4 | Q6SA08 | Testis-specific serine/threonine-protein kinase 4 | chr14 | Not Cancer Driver | No | 1 | hippie, biogrid | 29 | 8 | 1 | 1 | 0 |
USP36_ENST00000312010 | USP36 | Q9P275 | Ubiquitin carboxyl-terminal hydrolase 36 | chr17 | Not Cancer Driver | No | 1 | intact, hippie, biogrid | 151 | 718 | 91 | 91 | 0 |
USP43 | USP43 | Q70EL4 | Ubiquitin carboxyl-terminal hydrolase 43 | chr17 | Not Cancer Driver | No | 1 | intact, hippie, biogrid | 134 | 562 | 56 | 56 | 0 |
WDR36 | WDR36 | Q8NI36 | WD repeat-containing protein 36 | chr5 | Not Cancer Driver | No | 2 | hippie, biogrid | 140 | 89 | 11 | 11 | 2 |
XRN2 | XRN2 | Q9H0D6 | 5'-3' exoribonuclease 2 | chr20 | Not Cancer Driver | No | 1 | hippie | 129 | 427 | 63 | 63 | 0 |
ZC3H18_ENST00000301011 | ZC3H18 | Q86VM9 | Zinc finger CCCH domain-containing protein 18 | chr16 | Not Cancer Driver | No | 1 | hippie | 139 | 929 | 134 | 134 | 0 |
ZNF467 | ZNF467 | Q7Z7K2 | Zinc finger protein 467 | chr7 | Not Cancer Driver | No | 1 | hippie, biogrid | 75 | 345 | 37 | 37 | 0 |
ZNF512 | ZNF512 | Q96ME7 | Zinc finger protein 512 | chr2 | Not Cancer Driver | No | 2 | intact, hippie, biogrid | 76 | 280 | 42 | 42 | 0 |
ZNF746_ENST00000340622 | ZNF746 | Q6NUN9 | Zinc finger protein 746 | chr7 | Not Cancer Driver | No | 1 | hippie | 93 | 436 | 56 | 56 | 0 |
Identifier |
UniProt Gene |
UniProt Accession |
UniProt Name |
Chromosome |
Cancer Database |
Cancer Driver |
Number of independent pubication |
Interaction Database |
Number of missense mutations |
Number of disordered residues |
Number of mutations in disordered residues |
Number of mutations in disordered residues |
Number of omim mutations |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|