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VPS45_ENST00000644510 ,VPS45 ,Q9NRW7
  • Uniprot Accession= Q9NRW7
  • Ensembl Transcript= ENST00000644510.1
  • Uniprot Name= VPS45
  • Name= Vacuolar protein sorting-associated protein 45
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 26
  • Number of Interaction partner in biogrid: 97
  • Number of Interaction partner in hippie: 107
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ANKFY1_ENST00000341657 ANKFY1 Q9P2R3 Rabankyrin-5 chr17 Not Cancer Driver No 1 hippie, biogrid 109 185 29 29 0
AP2B1_ENST00000621914 AP2B1 P63010 AP-2 complex subunit beta chr17 Not Cancer Driver No 1 hippie, biogrid 85 95 12 12 0
ARF6 ARF6 P62330 ADP-ribosylation factor 6 chr14 Not Cancer Driver No 1 hippie, biogrid 18 5 0 0 0
ARFGAP2 ARFGAP2 Q8N6H7 ADP-ribosylation factor GTPase-activating protein 2 chr11 Not Cancer Driver No 1 biogrid 62 345 40 40 0
ARIH2 ARIH2 O95376 E3 ubiquitin-protein ligase ARIH2 chr3 Not Cancer Driver No 1 biogrid 64 85 11 11 0
ARL5B ARL5B Q96KC2 ADP-ribosylation factor-like protein 5B chr10 Not Cancer Driver No 1 biogrid 31 0 0 0 0
ASPH ASPH Q12797 Aspartyl/asparaginyl beta-hydroxylase chr8 Not Cancer Driver No 1 hippie, biogrid 109 373 53 53 1
B3GAT1_ENST00000312527 B3GAT1 Q9P2W7 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 chr11 Not Cancer Driver No 1 hippie, biogrid 85 93 32 32 0
BAZ1A_ENST00000382422 BAZ1A Q9NRL2 Bromodomain adjacent to zinc finger domain protein 1A chr14 Census Yes 1 biogrid 156 752 65 65 0
BCAR3_ENST00000260502 BCAR3 O75815 Breast cancer anti-estrogen resistance protein 3 chr1 Not Cancer Driver No 1 hippie 102 395 42 42 0
BET1 BET1 O15155 BET1 homolog chr7 Not Cancer Driver No 1 hippie 14 7 2 2 0
CAND1 CAND1 Q86VP6 Cullin-associated NEDD8-dissociated protein 1 chr12 Not Cancer Driver No 1 biogrid 161 88 7 7 0
CASP8_ENST00000432109 CASP8 Q14790 Caspase-8 chr2 Census, Compendium Yes 1 intact, hippie 142 106 12 12 1
CAV1 CAV1 Q03135 Caveolin-1 chr7 Not Cancer Driver No 1 hippie, biogrid 30 2 0 0 0
CBL CBL P22681 E3 ubiquitin-protein ligase CBL chr11 Census, Compendium Yes 1 biogrid 115 512 56 56 4
CDC42_ENST00000344548 CDC42 P60953 Cell division control protein 42 homolog chr1 Not Cancer Driver No 1 hippie 39 23 2 2 1
CEP128_ENST00000281129 CEP128 Q6ZU80 Centrosomal protein of 128 kDa chr14 Not Cancer Driver No 1 hippie 195 897 167 167 0
CEP152 CEP152 O94986 Centrosomal protein of 152 kDa chr15 Not Cancer Driver No 1 intact, hippie 204 986 110 110 2
COPS5 COPS5 Q92905 COP9 signalosome complex subunit 5 chr8 Not Cancer Driver No 1 hippie 36 32 7 7 0
DAG1_ENST00000515359 DAG1 Q14118 Dystroglycan 1 chr3 Not Cancer Driver No 1 hippie, biogrid 102 485 61 61 4
DDX58 DDX58 O95786 Antiviral innate immune response receptor RIG-I chr9 Not Cancer Driver No 1 hippie 118 61 10 10 2
DIRAS3_ENST00000646789 DIRAS3 O95661 GTP-binding protein Di-Ras3 chr1 Not Cancer Driver No 1 hippie, biogrid 38 21 3 3 0
EBAG9_ENST00000620557 EBAG9 O00559 Receptor-binding cancer antigen expressed on SiSo cells chr8 Not Cancer Driver No 1 hippie, biogrid 35 173 29 29 0
EEA1 EEA1 Q15075 Early endosome antigen 1 chr12 Not Cancer Driver No 1 intact, hippie 151 1168 126 126 0
EED_ENST00000263360 EED O75530 Polycomb protein EED chr11 Census Yes 1 biogrid 64 79 11 11 6
EGLN3 EGLN3 Q9H6Z9 Prolyl hydroxylase EGLN3 chr14 Not Cancer Driver No 1 hippie 33 13 0 0 0
EHD4 EHD4 Q9H223 EH domain-containing protein 4 chr15 Not Cancer Driver No 1 hippie 54 98 7 7 0
EP300 EP300 Q09472 Histone acetyltransferase p300 chr22 Census, Compendium Yes 1 biogrid 334 1790 196 196 1
ESR1_ENST00000206249 ESR1 P03372 Estrogen receptor chr6 Census, Compendium Yes 2 intact, hippie 121 195 27 27 2
ESR2 ESR2 Q92731 Estrogen receptor beta chr14 Not Cancer Driver No 1 hippie 90 92 11 11 1
EZH2_ENST00000460911 EZH2 Q15910 Histone-lysine N-methyltransferase EZH2 chr7 Census, Compendium Yes 1 biogrid 120 284 44 44 11
FAM20C FAM20C Q8IXL6 Extracellular serine/threonine protein kinase FAM20C chr7 Not Cancer Driver No 1 hippie 33 188 3 3 9
FGFR1_ENST00000447712 FGFR1 P11362 Fibroblast growth factor receptor 1 chr8 Census, Compendium Yes 1 intact 152 230 43 43 74
FGFR4 FGFR4 P22455 Fibroblast growth factor receptor 4 chr5 Census, Compendium Yes 1 intact 113 162 28 28 0
GJA1 GJA1 P17302 Gap junction alpha-1 protein chr6 Not Cancer Driver No 1 hippie, biogrid 86 110 26 26 50
GJD3 GJD3 Q8N144 Gap junction delta-3 protein chr17 Not Cancer Driver No 1 hippie, biogrid 5 79 0 0 0
GOLGA1 GOLGA1 Q92805 Golgin subfamily A member 1 chr9 Not Cancer Driver No 1 hippie, biogrid 99 582 77 77 0
GPRC5D GPRC5D Q9NZD1 G-protein coupled receptor family C group 5 member D chr12 Not Cancer Driver No 1 hippie, biogrid 32 32 1 1 0
HDAC8 HDAC8 Q9BY41 Histone deacetylase 8 chrX Not Cancer Driver No 1 biogrid 54 32 4 4 4
HNRNPD HNRNPD Q14103 Heterogeneous nuclear ribonucleoprotein D0 chr4 Not Cancer Driver No 1 biogrid 39 206 19 19 0
HNRNPL HNRNPL P14866 Heterogeneous nuclear ribonucleoprotein L chr19 Not Cancer Driver No 1 hippie 89 283 29 29 0
HOOK1 HOOK1 Q9UJC3 Protein Hook homolog 1 chr1 Not Cancer Driver No 1 hippie 97 427 59 59 0
HOOK3 HOOK3 Q86VS8 Protein Hook homolog 3 chr8 Census Yes 1 hippie 79 493 55 55 0
HRAS HRAS P01112 GTPase HRas chr11 Census, Compendium Yes 1 intact, hippie, biogrid 107 16 4 4 18
HSCB HSCB Q8IWL3 Iron-sulfur cluster co-chaperone protein HscB chr22 Not Cancer Driver No 1 intact, hippie 36 25 6 6 0
HSD3B7 HSD3B7 Q9H2F3 3 beta-hydroxysteroid dehydrogenase type 7 chr16 Not Cancer Driver No 1 hippie, biogrid 43 27 5 5 2
HSF2BP HSF2BP O75031 Heat shock factor 2-binding protein chr21 Not Cancer Driver No 1 hippie, biogrid 52 23 3 3 1
HSP90AB1 HSP90AB1 P08238 Heat shock protein HSP 90-beta chr6 Census, Compendium Yes 1 biogrid 100 254 43 43 0
HVCN1_ENST00000620084 HVCN1 Q96D96 Voltage-gated hydrogen channel 1 chr12 Not Cancer Driver No 1 hippie, biogrid 51 52 13 13 0
IFITM1_ENST00000528780 IFITM1 P13164 Interferon-induced transmembrane protein 1 chr11 Not Cancer Driver No 1 hippie, biogrid 19 0 0 0 0
IFITM3 IFITM3 Q01628 Interferon-induced transmembrane protein 3 chr11 Not Cancer Driver No 1 hippie, biogrid 69 18 5 5 0
IGF1R IGF1R P08069 Insulin-like growth factor 1 receptor chr15 Not Cancer Driver No 2 hippie, biogrid 183 265 37 37 6
KRAS KRAS P01116 GTPase KRas chr12 Census, Compendium Yes 2 intact, hippie, biogrid 788 7 2 2 27
LAMP1 LAMP1 P11279 Lysosome-associated membrane glycoprotein 1 chr13 Not Cancer Driver No 2 hippie, biogrid 47 93 10 10 0
LAMP2_ENST00000200639 LAMP2 P13473 Lysosome-associated membrane glycoprotein 2 chrX Not Cancer Driver No 1 hippie, biogrid 43 55 7 7 1
LAMP3 LAMP3 Q9UQV4 Lysosome-associated membrane glycoprotein 3 chr3 Not Cancer Driver No 1 hippie, biogrid 67 222 38 38 0
LAMTOR1 LAMTOR1 Q6IAA8 Ragulator complex protein LAMTOR1 chr11 Not Cancer Driver No 1 hippie, biogrid 13 96 7 7 0
LRRK2 LRRK2 Q5S007 Leucine-rich repeat serine/threonine-protein kinase 2 chr12 Not Cancer Driver No 1 intact, hippie 519 90 17 17 23
LSR_ENST00000361790 LSR Q86X29 Lipolysis-stimulated lipoprotein receptor chr19 Not Cancer Driver No 2 hippie, biogrid 89 330 42 42 0
MAGEA3 MAGEA3 P43357 Melanoma-associated antigen 3 chrX Not Cancer Driver No 1 hippie 79 103 18 18 0
MAN2A1 MAN2A1 Q16706 Alpha-mannosidase 2 chr5 Not Cancer Driver No 1 biogrid 165 83 9 9 0
MARCKS MARCKS P29966 Myristoylated alanine-rich C-kinase substrate chr6 Not Cancer Driver No 1 hippie, biogrid 14 328 14 14 0
METTL7A_ENST00000332160 METTL7A Q9H8H3 Putative methyltransferase-like protein 7A chr12 Not Cancer Driver No 1 hippie, biogrid 31 0 0 0 0
NAPA NAPA P54920 Alpha-soluble NSF attachment protein chr19 Not Cancer Driver No 2 hippie, biogrid 33 11 0 0 0
NAPG NAPG Q99747 Gamma-soluble NSF attachment protein chr18 Not Cancer Driver No 1 hippie, biogrid 35 56 3 3 0
NCOR1 NCOR1 O75376 Nuclear receptor corepressor 1 chr17 Census, Compendium Yes 1 biogrid 352 2347 340 340 0
NINL NINL Q9Y2I6 Ninein-like protein chr20 Not Cancer Driver No 1 intact, hippie 230 881 150 150 0
NIPAL3 NIPAL3 Q6P499 NIPA-like protein 3 chr1 Not Cancer Driver No 2 intact, hippie, biogrid 54 20 3 3 0
NPAS1_ENST00000449844 NPAS1 Q99742 Neuronal PAS domain-containing protein 1 chr19 Not Cancer Driver No 1 hippie, biogrid 53 309 23 23 0
NRAS NRAS P01111 GTPase NRas chr1 Census, Compendium Yes 1 hippie, biogrid 284 10 0 0 14
NTRK1 NTRK1 P04629 High affinity nerve growth factor receptor chr1 Census, Compendium Yes 1 hippie 168 57 8 8 25
OCRL OCRL Q01968 Inositol polyphosphate 5-phosphatase OCRL chrX Not Cancer Driver No 1 hippie 151 126 24 24 41
PAX2_ENST00000428433 PAX2 Q02962 Paired box protein Pax-2 chr10 Not Cancer Driver No 1 intact, hippie 62 296 48 48 23
PTEN PTEN P60484 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN chr10 Census, Compendium Yes 1 biogrid 505 76 4 4 41
PTPN1 PTPN1 P18031 Tyrosine-protein phosphatase non-receptor type 1 chr20 Not Cancer Driver No 1 intact, hippie 49 140 25 25 0
RAB11A RAB11A P62491 Ras-related protein Rab-11A chr15 Not Cancer Driver No 1 hippie, biogrid 31 43 4 4 0
RAB1B RAB1B Q9H0U4 Ras-related protein Rab-1B chr11 Not Cancer Driver No 1 biogrid 24 40 3 3 0
RAB2A RAB2A P61019 Ras-related protein Rab-2A chr8 Not Cancer Driver No 2 hippie, biogrid 22 58 4 4 0
RAB35 RAB35 Q15286 Ras-related protein Rab-35 chr12 Not Cancer Driver No 1 hippie, biogrid 25 25 2 2 0
RAB3B RAB3B P20337 Ras-related protein Rab-3B chr1 Not Cancer Driver No 1 hippie, biogrid 36 25 6 6 0
RAB4A RAB4A P20338 Ras-related protein Rab-4A chr1 Not Cancer Driver No 1 hippie, biogrid 26 32 11 11 0
RAB5A RAB5A P20339 Ras-related protein Rab-5A chr3 Not Cancer Driver No 3 intact, hippie, biogrid 32 65 15 15 0
RAB5C_ENST00000393860 RAB5C P51148 Ras-related protein Rab-5C chr17 Not Cancer Driver No 1 hippie, biogrid 24 50 4 4 0
RAB7A RAB7A P51149 Ras-related protein Rab-7a chr3 Not Cancer Driver No 1 biogrid 27 11 0 0 4
RAB9A RAB9A P51151 Ras-related protein Rab-9A chrX Not Cancer Driver No 1 hippie, biogrid 18 21 1 1 0
RABGEF1_ENST00000284957 RABGEF1 Q9UJ41 Rab5 GDP/GTP exchange factor chr7 Not Cancer Driver No 1 biogrid 73 175 35 35 0
RAC1_ENST00000348035 RAC1 P63000 Ras-related C3 botulinum toxin substrate 1 chr7 Census, Compendium Yes 1 hippie 66 2 1 1 6
RAC2 RAC2 P15153 Ras-related C3 botulinum toxin substrate 2 chr22 Not Cancer Driver No 1 hippie 31 0 0 0 2
RAC3 RAC3 P60763 Ras-related C3 botulinum toxin substrate 3 chr17 Not Cancer Driver No 1 hippie 24 0 0 0 4
RB1CC1 RB1CC1 Q8TDY2 RB1-inducible coiled-coil protein 1 chr8 Not Cancer Driver No 1 intact, hippie 202 578 75 75 0
RBSN RBSN Q9H1K0 Rabenosyn-5 chr3 Not Cancer Driver No 5 intact, hippie, biogrid 118 533 85 85 0
RET RET P07949 Proto-oncogene tyrosine-protein kinase receptor Ret chr10 Census, Compendium Yes 1 intact 208 105 12 12 139
RFX3_ENST00000617270 RFX3 P48380 Transcription factor RFX3 chr9 Not Cancer Driver No 1 hippie 113 308 41 41 0
RHOA RHOA P61586 Transforming protein RhoA chr3 Census, Compendium Yes 1 hippie 99 46 13 13 2
RHOB RHOB P62745 Rho-related GTP-binding protein RhoB chr2 Not Cancer Driver No 2 hippie, biogrid 52 19 2 2 0
RHOC_ENST00000369642 RHOC P08134 Rho-related GTP-binding protein RhoC chr1 Not Cancer Driver No 1 hippie 30 53 7 7 0
RHOD RHOD O00212 Rho-related GTP-binding protein RhoD chr11 Not Cancer Driver No 1 hippie 20 10 0 0 0
RHOF RHOF Q9HBH0 Rho-related GTP-binding protein RhoF chr12 Not Cancer Driver No 1 hippie 18 10 0 0 0
RHOG_ENST00000396978 RHOG P84095 Rho-related GTP-binding protein RhoG chr11 Not Cancer Driver No 1 hippie 26 22 5 5 0
RHOH_ENST00000617441 RHOH Q15669 Rho-related GTP-binding protein RhoH chr4 Census Yes 1 hippie 41 12 3 3 0
RHOJ RHOJ Q9H4E5 Rho-related GTP-binding protein RhoJ chr14 Not Cancer Driver No 1 hippie 39 0 0 0 0
RND2 RND2 P52198 Rho-related GTP-binding protein RhoN chr17 Not Cancer Driver No 1 hippie 19 54 4 4 0
SAR1A_ENST00000373238 SAR1A Q9NR31 GTP-binding protein SAR1a chr10 Not Cancer Driver No 1 biogrid 23 4 0 0 0
SCFD1 SCFD1 Q8WVM8 Sec1 family domain-containing protein 1 chr14 Not Cancer Driver No 1 hippie, biogrid 66 117 12 12 0
SEC23B SEC23B Q15437 Protein transport protein Sec23B chr20 Not Cancer Driver No 1 biogrid 105 82 4 4 7
SEC24C SEC24C P53992 Protein transport protein Sec24C chr10 Not Cancer Driver No 1 biogrid 121 402 38 38 0
SEC31A_ENST00000355196 SEC31A O94979 Protein transport protein Sec31A chr4 Not Cancer Driver No 1 biogrid 139 519 58 58 0
SLC33A1_ENST00000643144 SLC33A1 O00400 Acetyl-coenzyme A transporter 1 chr3 Not Cancer Driver No 1 biogrid 64 54 8 8 2
SLC39A4 SLC39A4 Q6P5W5 Zinc transporter ZIP4 chr8 Not Cancer Driver No 2 hippie, biogrid 77 116 11 11 9
SLC39A9 SLC39A9 Q9NUM3 Zinc transporter ZIP9 chr14 Not Cancer Driver No 1 biogrid 34 44 4 4 0
SNAP29 SNAP29 O95721 Synaptosomal-associated protein 29 chr22 Not Cancer Driver No 1 hippie, biogrid 21 246 20 20 0
SNTG1 SNTG1 Q9NSN8 Gamma-1-syntrophin chr8 Not Cancer Driver No 1 hippie 204 3 1 1 0
STX12 STX12 Q86Y82 Syntaxin-12 chr1 Not Cancer Driver No 1 hippie, biogrid 21 156 9 9 0
STX16 STX16 O14662 Syntaxin-16 chr20 Not Cancer Driver No 4 intact, hippie, biogrid 45 120 12 12 0
STX4 STX4 Q12846 Syntaxin-4 chr16 Not Cancer Driver No 1 hippie, biogrid 50 152 20 20 0
STX5 STX5 Q13190 Syntaxin-5 chr11 Not Cancer Driver No 1 intact 36 147 14 14 0
STX6 STX6 O43752 Syntaxin-6 chr1 Not Cancer Driver No 3 hippie, biogrid 33 78 11 11 0
STX7 STX7 O15400 Syntaxin-7 chr6 Not Cancer Driver No 2 hippie, biogrid 29 164 14 14 0
STX8 STX8 Q9UNK0 Syntaxin-8 chr17 Not Cancer Driver No 1 hippie, biogrid 32 98 10 10 0
STYK1 STYK1 Q6J9G0 Tyrosine-protein kinase STYK1 chr12 Not Cancer Driver No 1 intact 83 35 10 10 0
TBL1XR1 TBL1XR1 Q9BZK7 F-box-like/WD repeat-containing protein TBL1XR1 chr3 Census, Compendium Yes 1 biogrid 82 136 19 19 4
TCF3 TCF3 P15923 Transcription factor E2-alpha chr19 Census Yes 1 biogrid 52 649 52 52 0
TFRC_ENST00000392396 TFRC P02786 Transferrin receptor protein 1 chr3 Census Yes 1 hippie, biogrid 89 80 6 6 1
TGOLN2_ENST00000377386 TGOLN2 O43493 Trans-Golgi network integral membrane protein 2 chr2 Not Cancer Driver No 1 intact, hippie 51 399 46 46 0
TMEM17 TMEM17 Q86X19 Transmembrane protein 17 chr2 Not Cancer Driver No 1 intact, hippie 22 14 2 2 0
TMEM171 TMEM171 Q8WVE6 Transmembrane protein 171 chr5 Not Cancer Driver No 1 hippie, biogrid 54 150 18 18 0
TMEM9B TMEM9B Q9NQ34 Transmembrane protein 9B chr11 Not Cancer Driver No 1 hippie, biogrid 12 0 0 0 0
TMSB10 TMSB10 P63313 Thymosin beta-10 chr2 Not Cancer Driver No 1 hippie, biogrid 2 44 2 2 0
TRAPPC11 TRAPPC11 Q7Z392 Trafficking protein particle complex subunit 11 chr4 Not Cancer Driver No 1 biogrid 109 44 5 5 1
TRAPPC2L_ENST00000301021 TRAPPC2L Q9UL33 Trafficking protein particle complex subunit 2-like protein chr16 Not Cancer Driver No 1 biogrid 21 0 0 0 1
TRAPPC2_ENST00000359680 TRAPPC2 P0DI81 Trafficking protein particle complex subunit 2 chrX Not Cancer Driver No 1 biogrid 11 0 0 0 4
TRAPPC5 TRAPPC5 Q8IUR0 Trafficking protein particle complex subunit 5 chr19 Not Cancer Driver No 1 biogrid 28 0 0 0 0
UBE2M UBE2M P61081 NEDD8-conjugating enzyme Ubc12 chr19 Not Cancer Driver No 1 biogrid 30 32 6 6 0
VAMP4 VAMP4 O75379 Vesicle-associated membrane protein 4 chr1 Not Cancer Driver No 2 intact, hippie, biogrid 9 80 6 6 0
VAMP5 VAMP5 O95183 Vesicle-associated membrane protein 5 chr2 Not Cancer Driver No 2 intact, hippie, biogrid 17 19 1 1 0
VPS11 VPS11 Q9H270 Vacuolar protein sorting-associated protein 11 homolog chr11 Not Cancer Driver No 1 hippie 96 118 6 6 1
VPS18 VPS18 Q9P253 Vacuolar protein sorting-associated protein 18 homolog chr15 Not Cancer Driver No 1 hippie 96 86 7 7 0
VPS33A VPS33A Q96AX1 Vacuolar protein sorting-associated protein 33A chr12 Not Cancer Driver No 1 hippie, biogrid 73 46 8 8 1
VPS4B VPS4B O75351 Vacuolar protein sorting-associated protein 4B chr18 Not Cancer Driver No 1 hippie, biogrid 52 195 22 22 0
VPS51 VPS51 Q9UID3 Vacuolar protein sorting-associated protein 51 homolog chr11 Not Cancer Driver No 1 biogrid 75 150 11 11 1
VPS53 VPS53 Q5VIR6 Vacuolar protein sorting-associated protein 53 homolog chr17 Not Cancer Driver No 1 biogrid 83 172 27 27 1
VTI1A VTI1A Q96AJ9 Vesicle transport through interaction with t-SNAREs homolog 1A chr10 Census Yes 1 hippie, biogrid 21 138 13 13 0
VTI1B VTI1B Q9UEU0 Vesicle transport through interaction with t-SNAREs homolog 1B chr14 Not Cancer Driver No 3 hippie, biogrid 25 192 20 20 0
YKT6 YKT6 O15498 Synaptobrevin homolog YKT6 chr7 Not Cancer Driver No 1 intact 19 21 2 2 0
ZFPL1 ZFPL1 O95159 Zinc finger protein-like 1 chr11 Not Cancer Driver No 1 hippie, biogrid 40 127 16 16 0
ZNF827 ZNF827 Q17R98 Zinc finger protein 827 chr4 Not Cancer Driver No 1 hippie, biogrid 158 754 123 123 0