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UBE4B ,UBE4B ,O95155
  • Uniprot Accession= O95155
  • Ensembl Transcript= ENST00000343090.10
  • Uniprot Name= UBE4B
  • Name= Ubiquitin conjugation factor E4 B
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 8
  • Number of Interaction partner in biogrid: 52
  • Number of Interaction partner in hippie: 109
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
AHCYL1 AHCYL1 O43865 S-adenosylhomocysteine hydrolase-like protein 1 chr1 Not Cancer Driver No 1 hippie, biogrid 58 108 10 10 0
AMZ1 AMZ1 Q400G9 Archaemetzincin-1 chr7 Not Cancer Driver No 1 hippie, biogrid 78 147 18 18 0
APP APP P05067 Amyloid-beta precursor protein chr21 Not Cancer Driver No 1 hippie 128 418 71 71 17
ATP6V1F_ENST00000249289 ATP6V1F Q16864 V-type proton ATPase subunit F chr7 Not Cancer Driver No 1 hippie, biogrid 14 12 1 1 0
ATXN3 ATXN3 P54252 Ataxin-3 chr14 Not Cancer Driver No 1 intact, hippie 46 181 24 24 0
BTRC BTRC Q9Y297 F-box/WD repeat-containing protein 1A chr10 Not Cancer Driver No 1 hippie 80 45 4 4 0
CASP3 CASP3 P42574 Caspase-3 chr4 Census Yes 1 hippie 32 62 5 5 0
CASP6 CASP6 P55212 Caspase-6 chr4 Not Cancer Driver No 1 hippie 28 24 4 4 0
CASP7_ENST00000345633 CASP7 P55210 Caspase-7 chr10 Not Cancer Driver No 1 hippie 38 73 10 10 0
CBL CBL P22681 E3 ubiquitin-protein ligase CBL chr11 Census, Compendium Yes 1 hippie 115 512 56 56 4
CDC25A CDC25A P30304 M-phase inducer phosphatase 1 chr3 Not Cancer Driver No 2 intact, hippie, biogrid 63 313 35 35 0
CDC27_ENST00000066544 CDC27 P30260 Cell division cycle protein 27 homolog chr17 Not Cancer Driver No 1 hippie 179 289 75 75 0
CDKN2A_ENST00000304494 CDKN2A P42771 Cyclin-dependent kinase inhibitor 2A chr9 Census, Compendium Yes 1 intact, hippie 166 83 88 88 36
CNTN2 CNTN2 Q02246 Contactin-2 chr1 Not Cancer Driver No 1 hippie 155 370 61 61 0
CTDP1 CTDP1 Q9Y5B0 RNA polymerase II subunit A C-terminal domain phosphatase chr18 Not Cancer Driver No 1 hippie 121 624 87 87 0
DNAJC7 DNAJC7 Q99615 DnaJ homolog subfamily C member 7 chr17 Not Cancer Driver No 1 hippie 41 102 9 9 0
DUSP16 DUSP16 Q9BY84 Dual specificity protein phosphatase 16 chr12 Compendium Yes 1 hippie, biogrid 70 273 34 34 0
EDEM1 EDEM1 Q92611 ER degradation-enhancing alpha-mannosidase-like protein 1 chr3 Not Cancer Driver No 1 hippie 54 141 5 5 0
EGFR EGFR P00533 Epidermal growth factor receptor chr7 Census, Compendium Yes 1 hippie 444 223 35 35 1
ELAVL1 ELAVL1 Q15717 ELAV-like protein 1 chr19 Not Cancer Driver No 1 hippie 69 43 5 5 0
ESR1_ENST00000206249 ESR1 P03372 Estrogen receptor chr6 Census, Compendium Yes 1 intact, hippie 121 195 27 27 2
EYA3 EYA3 Q99504 Eyes absent homolog 3 chr1 Not Cancer Driver No 1 hippie, biogrid 58 310 40 40 0
FBXW11 FBXW11 Q9UKB1 F-box/WD repeat-containing protein 11 chr5 Not Cancer Driver No 1 hippie 75 20 3 3 7
FEZ1 FEZ1 Q99689 Fasciculation and elongation protein zeta-1 chr11 Not Cancer Driver No 1 hippie 66 277 49 49 0
FOXK1 FOXK1 P85037 Forkhead box protein K1 chr7 Not Cancer Driver No 1 hippie, biogrid 97 511 65 65 0
GZMB GZMB P10144 Granzyme B chr14 Not Cancer Driver No 1 hippie 49 103 23 23 0
HDLBP_ENST00000391976 HDLBP Q00341 Vigilin chr2 Not Cancer Driver No 1 hippie, biogrid 195 555 87 87 0
HGS HGS O14964 Hepatocyte growth factor-regulated tyrosine kinase substrate chr17 Not Cancer Driver No 1 hippie 109 528 74 74 0
HNRNPL HNRNPL P14866 Heterogeneous nuclear ribonucleoprotein L chr19 Not Cancer Driver No 1 hippie 89 283 29 29 0
HRAS HRAS P01112 GTPase HRas chr11 Census, Compendium Yes 1 hippie 107 16 4 4 18
IGBP1_ENST00000356413 IGBP1 P78318 Immunoglobulin-binding protein 1 chrX Not Cancer Driver No 1 hippie, biogrid 51 193 28 28 0
LMBR1L LMBR1L Q6UX01 Protein LMBR1L chr12 Not Cancer Driver No 1 hippie 57 4 0 0 0
LRRC73 LRRC73 Q5JTD7 Leucine-rich repeat-containing protein 73 chr6 Not Cancer Driver No 1 hippie, biogrid 33 92 14 14 0
MAPK3 MAPK3 P27361 Mitogen-activated protein kinase 3 chr16 Not Cancer Driver No 1 hippie 38 49 5 5 0
MDM2_ENST00000539479 MDM2 Q00987 E3 ubiquitin-protein ligase Mdm2 chr12 Census, Compendium Yes 1 hippie 56 297 37 37 0
MRPL53 MRPL53 Q96EL3 39S ribosomal protein L53, mitochondrial chr2 Not Cancer Driver No 1 hippie, biogrid 20 22 1 1 0
MYC_ENST00000377970 MYC P01106 Myc proto-oncogene protein chr8 Census, Compendium Yes 1 hippie 80 299 46 46 0
NDUFA2 NDUFA2 O43678 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 chr5 Not Cancer Driver No 1 hippie, biogrid 10 0 0 0 0
NDUFA7 NDUFA7 O95182 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 chr19 Not Cancer Driver No 1 hippie, biogrid 16 103 13 13 0
NLRP10 NLRP10 Q86W26 NACHT, LRR and PYD domains-containing protein 10 chr11 Not Cancer Driver No 1 hippie, biogrid 201 96 34 34 0
NTRK1 NTRK1 P04629 High affinity nerve growth factor receptor chr1 Census, Compendium Yes 1 hippie 168 57 8 8 25
NUDCD3 NUDCD3 Q8IVD9 NudC domain-containing protein 3 chr7 Not Cancer Driver No 1 hippie 30 199 16 16 0
NUSAP1 NUSAP1 Q9BXS6 Nucleolar and spindle-associated protein 1 chr15 Not Cancer Driver No 1 hippie 49 415 42 42 0
OR7A5 OR7A5 Q15622 Olfactory receptor 7A5 chr19 Not Cancer Driver No 1 hippie, biogrid 63 1 0 0 0
OTUB1_ENST00000428192 OTUB1 Q96FW1 Ubiquitin thioesterase OTUB1 chr11 Not Cancer Driver No 1 hippie 31 33 2 2 0
PCDHA8 PCDHA8 Q9Y5H6 Protocadherin alpha-8 chr5 Not Cancer Driver No 1 hippie, biogrid 344 273 73 73 0
PCID2_ENST00000375479 PCID2 Q5JVF3 PCI domain-containing protein 2 chr13 Not Cancer Driver No 1 hippie, biogrid 46 13 5 5 0
PDE3A PDE3A Q14432 cGMP-inhibited 3',5'-cyclic phosphodiesterase A chr12 Not Cancer Driver No 1 hippie 274 527 114 114 6
PGAM5 PGAM5 Q96HS1 Serine/threonine-protein phosphatase PGAM5, mitochondrial chr12 Not Cancer Driver No 1 hippie 32 102 12 12 0
PGRMC1 PGRMC1 O00264 Membrane-associated progesterone receptor component 1 chrX Not Cancer Driver No 1 hippie 30 74 16 16 0
PINK1 PINK1 Q9BXM7 Serine/threonine-protein kinase PINK1, mitochondrial chr1 Not Cancer Driver No 1 hippie 57 99 13 13 23
PLEKHA4 PLEKHA4 Q9H4M7 Pleckstrin homology domain-containing family A member 4 chr19 Not Cancer Driver No 1 hippie 136 687 128 128 0
PPIF PPIF P30405 Peptidyl-prolyl cis-trans isomerase F, mitochondrial chr10 Not Cancer Driver No 1 hippie, biogrid 19 43 4 4 0
PPP3CA PPP3CA Q08209 Protein phosphatase 3 catalytic subunit alpha chr4 Compendium Yes 1 hippie 85 140 27 27 7
PRC1 PRC1 O43663 Protein regulator of cytokinesis 1 chr15 Not Cancer Driver No 1 hippie 63 235 26 26 0
PRMT1 PRMT1 Q99873 Protein arginine N-methyltransferase 1 chr19 Not Cancer Driver No 1 hippie 50 18 1 1 0
PSMB1 PSMB1 P20618 Proteasome subunit beta type-1 chr6 Not Cancer Driver No 1 hippie, biogrid 25 14 2 2 0
RAD23A RAD23A P54725 UV excision repair protein RAD23 homolog A chr19 Not Cancer Driver No 1 hippie 50 283 41 41 0
RAD23B RAD23B P54727 UV excision repair protein RAD23 homolog B chr9 Not Cancer Driver No 2 hippie, biogrid 54 324 41 41 0
RBM12 RBM12 Q9NTZ6 RNA-binding protein 12 chr20 Not Cancer Driver No 1 hippie 100 617 67 67 0
RNF4 RNF4 P78317 E3 ubiquitin-protein ligase RNF4 chr4 Not Cancer Driver No 1 hippie 14 117 7 7 0
RPTOR RPTOR Q8N122 Regulatory-associated protein of mTOR chr17 Not Cancer Driver No 1 hippie 176 241 21 21 0
SARNP SARNP P82979 SAP domain-containing ribonucleoprotein chr12 Not Cancer Driver No 1 hippie, biogrid 27 195 27 27 0
SBDS SBDS Q9Y3A5 Ribosome maturation protein SBDS chr7 Census Yes 1 hippie, biogrid 28 12 1 1 2
SCO2_ENST00000395693 SCO2 O43819 Protein SCO2 homolog, mitochondrial chr22 Not Cancer Driver No 1 hippie, biogrid 31 51 8 8 8
SF3B4 SF3B4 Q15427 Splicing factor 3B subunit 4 chr1 Not Cancer Driver No 1 hippie, biogrid 69 273 56 56 0
SMAD4_ENST00000398417 SMAD4 Q13485 Mothers against decapentaplegic homolog 4 chr18 Census, Compendium Yes 1 hippie 198 195 17 17 8
SRPRB SRPRB Q9Y5M8 Signal recognition particle receptor subunit beta chr3 Not Cancer Driver No 1 hippie, biogrid 30 23 3 3 0
STAM STAM Q92783 Signal transducing adapter molecule 1 chr10 Not Cancer Driver No 1 hippie 73 361 40 40 0
STUB1 STUB1 Q9UNE7 E3 ubiquitin-protein ligase CHIP chr16 Not Cancer Driver No 1 hippie, biogrid 35 112 14 14 12
SULT1A1_ENST00000314752 SULT1A1 P50225 Sulfotransferase 1A1 chr16 Not Cancer Driver No 1 hippie, biogrid 69 14 3 3 0
THY1 THY1 P04216 Thy-1 membrane glycoprotein chr11 Not Cancer Driver No 1 hippie, biogrid 24 5 0 0 0
TP53_ENST00000445888 TP53 P04637 Cellular tumor antigen p53 chr17 Census, Compendium Yes 1 hippie 2891 282 1466 1466 83
TP63 TP63 Q9H3D4 Tumor protein 63 chr3 Census, Compendium Yes 1 hippie 229 398 143 143 28
TP73 TP73 O15350 Tumor protein p73 chr1 Not Cancer Driver No 1 hippie 82 443 55 55 0
TRIM25 TRIM25 Q14258 E3 ubiquitin/ISG15 ligase TRIM25 chr17 Not Cancer Driver No 1 hippie 59 225 20 20 0
TRIM28 TRIM28 Q13263 Transcription intermediary factor 1-beta chr19 Not Cancer Driver No 1 hippie 87 430 41 41 0
TRIP12_ENST00000283943 TRIP12 Q14669 E3 ubiquitin-protein ligase TRIP12 chr2 Not Cancer Driver No 1 hippie 224 845 117 117 4
TRIP6 TRIP6 Q15654 Thyroid receptor-interacting protein 6 chr7 Not Cancer Driver No 1 hippie, biogrid 62 268 19 19 0
TTC4 TTC4 O95801 Tetratricopeptide repeat protein 4 chr1 Not Cancer Driver No 1 hippie, biogrid 45 100 12 12 0
TTC9C_ENST00000532583 TTC9C Q8N5M4 Tetratricopeptide repeat protein 9C chr11 Not Cancer Driver No 1 hippie, biogrid 15 81 3 3 0
TTK TTK P33981 Dual specificity protein kinase TTK chr6 Not Cancer Driver No 1 hippie 136 352 46 46 0
UBA6 UBA6 A0AVT1 Ubiquitin-like modifier-activating enzyme 6 chr4 Not Cancer Driver No 1 hippie, biogrid 133 90 10 10 0
UBE2C UBE2C O00762 Ubiquitin-conjugating enzyme E2 C chr20 Not Cancer Driver No 1 hippie, biogrid 13 40 0 0 0
UBE2D1 UBE2D1 P51668 Ubiquitin-conjugating enzyme E2 D1 chr10 Not Cancer Driver No 1 hippie, biogrid 13 14 0 0 0
UBE2D2 UBE2D2 P62837 Ubiquitin-conjugating enzyme E2 D2 chr5 Compendium Yes 1 hippie 19 13 1 1 0
UBE2D3_ENST00000394801 UBE2D3 P61077 Ubiquitin-conjugating enzyme E2 D3 chr4 Not Cancer Driver No 1 intact, hippie 21 13 4 4 0
UBE2L3_ENST00000342192 UBE2L3 P68036 Ubiquitin-conjugating enzyme E2 L3 chr22 Not Cancer Driver No 1 hippie, biogrid 19 32 4 4 0
UBE2V1_ENST00000371674 UBE2V1 Q13404 Ubiquitin-conjugating enzyme E2 variant 1 chr20 Not Cancer Driver No 1 biogrid 19 51 5 5 0
UBE4B UBE4B O95155 Ubiquitin conjugation factor E4 B chr1 Not Cancer Driver No 1 hippie 158 434 49 49 0
UBL7_ENST00000565335 UBL7 Q96S82 Ubiquitin-like protein 7 chr15 Not Cancer Driver No 5 hippie, biogrid 31 192 22 22 0
UBQLN1 UBQLN1 Q9UMX0 Ubiquilin-1 chr9 Not Cancer Driver No 2 hippie, biogrid 64 543 58 58 0
UBXN1_ENST00000301935 UBXN1 Q04323 UBX domain-containing protein 1 chr11 Not Cancer Driver No 1 intact, hippie 35 271 33 33 0
UBXN7 UBXN7 O94888 UBX domain-containing protein 7 chr3 Not Cancer Driver No 1 hippie, biogrid 65 327 39 39 0
UCHL3 UCHL3 P15374 Ubiquitin carboxyl-terminal hydrolase isozyme L3 chr13 Not Cancer Driver No 1 hippie, biogrid 26 61 3 3 0
UFM1_ENST00000239878 UFM1 P61960 Ubiquitin-fold modifier 1 chr13 Not Cancer Driver No 1 hippie, biogrid 10 0 0 0 1
USP34 USP34 Q70CQ2 Ubiquitin carboxyl-terminal hydrolase 34 chr2 Not Cancer Driver No 1 hippie, biogrid 436 725 90 90 0
USP9X_ENST00000378308 USP9X Q93008 Probable ubiquitin carboxyl-terminal hydrolase FAF-X chrX Census, Compendium Yes 1 hippie, biogrid 339 405 51 51 1
VAV2 VAV2 P52735 Guanine nucleotide exchange factor VAV2 chr9 Not Cancer Driver No 1 intact, hippie 127 135 17 17 0
VCP VCP P55072 Transitional endoplasmic reticulum ATPase chr9 Not Cancer Driver No 4 intact, hippie, biogrid 88 186 16 16 16
VIRMA VIRMA Q69YN4 Protein virilizer homolog chr8 Not Cancer Driver No 1 hippie 211 631 93 93 0
VPS26A_ENST00000263559 VPS26A O75436 Vacuolar protein sorting-associated protein 26A chr10 Not Cancer Driver No 1 hippie, biogrid 27 44 2 2 0
VPS29_ENST00000549578 VPS29 Q9UBQ0 Vacuolar protein sorting-associated protein 29 chr12 Not Cancer Driver No 1 hippie, biogrid 24 0 0 0 0
VPS35 VPS35 Q96QK1 Vacuolar protein sorting-associated protein 35 chr16 Not Cancer Driver No 1 hippie, biogrid 68 99 9 9 1
VPS36 VPS36 Q86VN1 Vacuolar protein-sorting-associated protein 36 chr13 Not Cancer Driver No 1 hippie, biogrid 35 94 14 14 0
VPS4B VPS4B O75351 Vacuolar protein sorting-associated protein 4B chr18 Not Cancer Driver No 1 hippie, biogrid 52 195 22 22 0
XPC XPC Q01831 DNA repair protein complementing XP-C cells chr3 Census, Compendium Yes 1 hippie 88 479 48 48 2
ZFYVE19 ZFYVE19 Q96K21 Abscission/NoCut checkpoint regulator chr15 Not Cancer Driver No 1 hippie, biogrid 41 361 28 28 0
ZPR1 ZPR1 O75312 Zinc finger protein ZPR1 chr11 Not Cancer Driver No 1 hippie, biogrid 38 291 27 27 0
ZRANB2 ZRANB2 O95218 Zinc finger Ran-binding domain-containing protein 2 chr1 Not Cancer Driver No 1 hippie, biogrid 56 257 44 44 0