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TTR ,TTR ,P02766
  • Uniprot Accession= P02766
  • Ensembl Transcript= ENST00000237014.7
  • Uniprot Name= TTR
  • Name= Transthyretin
  • Chromosome= chr18
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 3
  • Number of Interaction partner in biogrid: 36
  • Number of Interaction partner in hippie: 131
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
A2M A2M P01023 Alpha-2-macroglobulin chr12 Not Cancer Driver No 1 hippie 260 144 22 22 0
ACTB_ENST00000646664 ACTB P60709 Actin, cytoplasmic 1 chr7 Not Cancer Driver No 1 hippie 112 43 5 5 5
AGER_ENST00000375076 AGER Q15109 Advanced glycosylation end product-specific receptor chr6 Not Cancer Driver No 1 hippie 31 297 21 21 0
AGPAT1 AGPAT1 Q99943 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha chr6 Not Cancer Driver No 1 hippie, biogrid 36 38 5 5 0
ALB ALB P02768 Albumin chr4 Compendium Yes 1 hippie 162 6 0 0 3
APOA1_ENST00000375320 APOA1 P02647 Apolipoprotein A-I chr11 Not Cancer Driver No 1 hippie 28 131 8 8 3
APP APP P05067 Amyloid-beta precursor protein chr21 Not Cancer Driver No 1 hippie 128 418 71 71 17
ARFGAP3 ARFGAP3 Q9NP61 ADP-ribosylation factor GTPase-activating protein 3 chr22 Not Cancer Driver No 1 hippie 53 321 38 38 0
ASB3 ASB3 Q9Y575 Ankyrin repeat and SOCS box protein 3 chr2 Not Cancer Driver No 1 hippie 71 0 0 0 0
ATF4_ENST00000404241 ATF4 P18848 Cyclic AMP-dependent transcription factor ATF-4 chr22 Not Cancer Driver No 1 hippie 53 259 38 38 0
ATF5_ENST00000595125 ATF5 Q9Y2D1 Cyclic AMP-dependent transcription factor ATF-5 chr19 Not Cancer Driver No 1 hippie 47 239 40 40 0
ATG7 ATG7 O95352 Ubiquitin-like modifier-activating enzyme ATG7 chr3 Compendium Yes 1 hippie, biogrid 77 53 8 8 6
ATP6V1B1 ATP6V1B1 P15313 V-type proton ATPase subunit B, kidney isoform chr2 Not Cancer Driver No 1 hippie 77 66 14 14 9
BAG6 BAG6 P46379 Large proline-rich protein BAG6 chr6 Not Cancer Driver No 1 hippie 98 861 79 79 0
CCAR2 CCAR2 Q8N163 Cell cycle and apoptosis regulator protein 2 chr8 Not Cancer Driver No 1 hippie 102 528 62 62 0
CCNA2_ENST00000618014 CCNA2 P20248 Cyclin-A2 chr4 Not Cancer Driver No 1 hippie, biogrid 45 186 19 19 0
CCR1 CCR1 P32246 C-C chemokine receptor type 1 chr3 Not Cancer Driver No 1 hippie, biogrid 69 14 5 5 0
CDR2 CDR2 Q01850 Cerebellar degeneration-related protein 2 chr16 Not Cancer Driver No 1 hippie 50 287 26 26 0
CEP126 CEP126 Q9P2H0 Centrosomal protein of 126 kDa chr11 Not Cancer Driver No 1 hippie 197 840 151 151 0
CFAP100 CFAP100 Q494V2 Cilia- and flagella-associated protein 100 chr3 Not Cancer Driver No 1 hippie 115 438 89 89 0
CHD3_ENST00000330494 CHD3 Q12873 Chromodomain-helicase-DNA-binding protein 3 chr17 Not Cancer Driver No 1 hippie, biogrid 235 1015 122 122 18
CIAO2B CIAO2B Q9Y3D0 Cytosolic iron-sulfur assembly component 2B chr16 Not Cancer Driver No 1 hippie 9 77 3 3 0
CIR1 CIR1 Q86X95 Corepressor interacting with RBPJ 1 chr2 Not Cancer Driver No 1 hippie, biogrid 46 385 42 42 0
CLEC11A CLEC11A Q9Y240 C-type lectin domain family 11 member A chr19 Not Cancer Driver No 1 hippie 23 184 20 20 0
CLU_ENST00000523500 CLU P10909 Clusterin chr8 Not Cancer Driver No 1 hippie 69 156 27 27 0
CNST CNST Q6PJW8 Consortin chr1 Not Cancer Driver No 1 hippie 113 499 82 82 0
COG8 COG8 H3BQV3 Conserved oligomeric Golgi complex subunit 8 chr16 Not Cancer Driver No 1 hippie 112 37 6 6 0
COPS3 COPS3 Q9UNS2 COP9 signalosome complex subunit 3 chr17 Not Cancer Driver No 1 hippie 55 67 10 10 0
CPNE6_ENST00000397016 CPNE6 O95741 Copine-6 chr14 Not Cancer Driver No 1 hippie 85 111 22 22 0
CRELD2_ENST00000328268 CRELD2 Q6UXH1 Protein disulfide isomerase CRELD2 chr22 Not Cancer Driver No 1 hippie 39 33 6 6 0
CTNND2 CTNND2 Q9UQB3 Catenin delta-2 chr5 Census Yes 1 hippie 386 837 254 254 0
CTSB CTSB P07858 Cathepsin B chr8 Not Cancer Driver No 1 hippie 41 7 2 2 0
DDR1_ENST00000324771 DDR1 Q08345 Epithelial discoidin domain-containing receptor 1 chr6 Not Cancer Driver No 1 hippie, biogrid 123 253 49 49 0
DDX31_ENST00000372153 DDX31 Q9H8H2 Probable ATP-dependent RNA helicase DDX31 chr9 Not Cancer Driver No 2 hippie, biogrid 99 342 38 38 0
DERL1 DERL1 Q9BUN8 Derlin-1 chr8 Not Cancer Driver No 1 hippie 28 11 1 1 0
DERL2 DERL2 Q9GZP9 Derlin-2 chr17 Not Cancer Driver No 1 hippie 19 15 1 1 0
DERL3_ENST00000318109 DERL3 Q96Q80 Derlin-3 chr22 Not Cancer Driver No 1 hippie 18 18 1 1 0
EEF1A1 EEF1A1 P68104 Elongation factor 1-alpha 1 chr6 Not Cancer Driver No 1 hippie, biogrid 109 100 14 14 0
ELP1 ELP1 O95163 Elongator complex protein 1 chr9 Not Cancer Driver No 1 hippie 143 157 23 23 2
ERG28 ERG28 Q9UKR5 Ergosterol biosynthetic protein 28 homolog chr14 Not Cancer Driver No 1 hippie 19 3 0 0 0
ESRP1_ENST00000642581 ESRP1 Q6NXG1 Epithelial splicing regulatory protein 1 chr8 Not Cancer Driver No 1 hippie 120 41 5 5 1
FAM135B FAM135B Q49AJ0 Protein FAM135B chr8 Census, Compendium Yes 1 hippie 743 576 283 283 0
FEZ1 FEZ1 Q99689 Fasciculation and elongation protein zeta-1 chr11 Not Cancer Driver No 1 hippie, biogrid 66 277 49 49 0
FEZ2_ENST00000405912 FEZ2 Q9UHY8 Fasciculation and elongation protein zeta-2 chr2 Not Cancer Driver No 1 hippie 37 245 29 29 0
FKBP7 FKBP7 Q9Y680 Peptidyl-prolyl cis-trans isomerase FKBP7 chr2 Not Cancer Driver No 1 hippie, biogrid 28 52 9 9 0
GET4 GET4 Q7L5D6 Golgi to ER traffic protein 4 homolog chr7 Not Cancer Driver No 1 hippie, biogrid 34 51 3 3 0
GNG8 GNG8 Q9UK08 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 chr19 Not Cancer Driver No 1 hippie, biogrid 2 16 1 1 0
GOLGA2_ENST00000611957 GOLGA2 Q08379 Golgin subfamily A member 2 chr9 Not Cancer Driver No 1 hippie 115 854 96 96 0
GPR141 GPR141 Q7Z602 Probable G-protein coupled receptor 141 chr7 Not Cancer Driver No 1 hippie 105 6 1 1 0
HDAC2 HDAC2 Q92769 Histone deacetylase 2 chr6 Not Cancer Driver No 1 hippie 46 145 14 14 0
HNRNPH3 HNRNPH3 P31942 Heterogeneous nuclear ribonucleoprotein H3 chr10 Not Cancer Driver No 1 hippie, biogrid 42 188 18 18 0
HSP90AA1_ENST00000216281 HSP90AA1 P07900 Heat shock protein HSP 90-alpha chr14 Census, Compendium Yes 1 hippie 106 257 37 37 0
HSPG2 HSPG2 P98160 Basement membrane-specific heparan sulfate proteoglycan core protein chr1 Compendium Yes 1 hippie 506 1709 194 194 1
INPP5A INPP5A Q14642 Inositol polyphosphate-5-phosphatase A chr10 Not Cancer Driver No 1 hippie, biogrid 59 7 4 4 0
INPP5K INPP5K Q9BT40 Inositol polyphosphate 5-phosphatase K chr17 Not Cancer Driver No 1 hippie 42 34 2 2 7
INS INS P01308 Insulin chr11 Not Cancer Driver No 1 hippie 15 5 1 1 22
ISCA2 ISCA2 Q86U28 Iron-sulfur cluster assembly 2 homolog, mitochondrial chr14 Not Cancer Driver No 1 hippie 13 38 3 3 1
ITLN2 ITLN2 Q8WWU7 Intelectin-2 chr1 Not Cancer Driver No 1 hippie, biogrid 56 21 4 4 0
KCTD15_ENST00000589786 KCTD15 Q96SI1 BTB/POZ domain-containing protein KCTD15 chr19 Not Cancer Driver No 1 hippie 33 89 14 14 0
KDSR KDSR Q06136 3-ketodihydrosphingosine reductase chr18 Census Yes 1 hippie 31 35 4 4 1
KIF1A_ENST00000320389 KIF1A Q12756 Kinesin-like protein KIF1A chr2 Not Cancer Driver No 1 hippie 275 594 79 79 35
KLHL20 KLHL20 Q9Y2M5 Kelch-like protein 20 chr1 Not Cancer Driver No 1 hippie 83 143 17 17 0
LANCL2 LANCL2 Q9NS86 LanC-like protein 2 chr7 Not Cancer Driver No 1 hippie, biogrid 71 44 5 5 0
LRP2 LRP2 P98164 Low-density lipoprotein receptor-related protein 2 chr2 Not Cancer Driver No 1 hippie 998 209 40 40 1
MARK3 MARK3 P27448 MAP/microtubule affinity-regulating kinase 3 chr14 Not Cancer Driver No 1 hippie, biogrid 92 376 49 49 1
MATN2 MATN2 O00339 Matrilin-2 chr8 Not Cancer Driver No 1 hippie, biogrid 151 167 26 26 0
METTL27 METTL27 Q8N6F8 Methyltransferase-like protein 27 chr7 Not Cancer Driver No 1 hippie 36 47 8 8 0
MNDA MNDA P41218 Myeloid cell nuclear differentiation antigen chr1 Not Cancer Driver No 1 hippie 180 172 76 76 0
MT3 MT3 P25713 Metallothionein-3 chr16 Not Cancer Driver No 1 hippie 7 0 0 0 0
MTMR6 MTMR6 Q9Y217 Myotubularin-related protein 6 chr13 Not Cancer Driver No 1 hippie, biogrid 87 68 16 16 0
MTMR9 MTMR9 Q96QG7 Myotubularin-related protein 9 chr8 Not Cancer Driver No 1 hippie, biogrid 60 45 7 7 0
NDUFA5_ENST00000355749 NDUFA5 Q16718 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 chr7 Not Cancer Driver No 1 hippie 10 10 1 1 0
NECAB2 NECAB2 Q7Z6G3 N-terminal EF-hand calcium-binding protein 2 chr16 Not Cancer Driver No 1 hippie 46 122 9 9 0
NGFR NGFR P08138 Tumor necrosis factor receptor superfamily member 16 chr17 Not Cancer Driver No 1 hippie 57 172 25 25 0
NPC2 NPC2 P61916 NPC intracellular cholesterol transporter 2 chr14 Not Cancer Driver No 2 hippie, biogrid 8 0 0 0 7
NUP43 NUP43 Q8NFH3 Nucleoporin Nup43 chr6 Not Cancer Driver No 1 hippie 47 103 9 9 0
OTUB1_ENST00000428192 OTUB1 Q96FW1 Ubiquitin thioesterase OTUB1 chr11 Not Cancer Driver No 1 hippie 31 33 2 2 0
OTUD7B OTUD7B Q6GQQ9 OTU domain-containing protein 7B chr1 Not Cancer Driver No 1 hippie 124 537 87 87 0
P2RX6 P2RX6 O15547 P2X purinoceptor 6 chr22 Not Cancer Driver No 1 hippie, biogrid 33 43 1 1 0
PALM PALM O75781 Paralemmin-1 chr19 Not Cancer Driver No 1 hippie 50 381 50 50 0
PDK1_ENST00000282077 PDK1 Q15118 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial chr2 Not Cancer Driver No 1 hippie, biogrid 52 50 10 10 0
PHF11 PHF11 Q9UIL8 PHD finger protein 11 chr13 Not Cancer Driver No 1 hippie, biogrid 34 82 10 10 0
PHYHIP PHYHIP Q92561 Phytanoyl-CoA hydroxylase-interacting protein chr8 Not Cancer Driver No 1 hippie, biogrid 44 25 4 4 0
PIK3R1 PIK3R1 P27986 Phosphatidylinositol 3-kinase regulatory subunit alpha chr5 Census, Compendium Yes 1 hippie 154 268 61 61 2
PIK3R5 PIK3R5 Q8WYR1 Phosphoinositide 3-kinase regulatory subunit 5 chr17 Not Cancer Driver No 1 hippie 143 316 55 55 1
PRKCI PRKCI P41743 Protein kinase C iota type chr3 Not Cancer Driver No 1 hippie 110 120 16 16 0
PRNP PRNP P04156 Major prion protein chr20 Not Cancer Driver No 1 hippie 36 115 7 7 18
PRPS2_ENST00000380668 PRPS2 P11908 Ribose-phosphate pyrophosphokinase 2 chrX Not Cancer Driver No 1 hippie 56 4 1 1 0
PSMD14 PSMD14 O00487 26S proteasome non-ATPase regulatory subunit 14 chr2 Not Cancer Driver No 1 hippie 23 67 6 6 0
RAI1 RAI1 Q7Z5J4 Retinoic acid-induced protein 1 chr17 Not Cancer Driver No 1 hippie 208 1690 188 188 0
RBP4 RBP4 P02753 Retinol-binding protein 4 chr10 Not Cancer Driver No 3 intact, hippie 30 8 1 1 4
RHBDD1 RHBDD1 Q8TEB9 Rhomboid-related protein 4 chr2 Not Cancer Driver No 1 hippie, biogrid 38 69 9 9 0
RNF115 RNF115 Q9Y4L5 E3 ubiquitin-protein ligase RNF115 chr1 Not Cancer Driver No 1 hippie 30 136 14 14 0
RNF183_ENST00000297894 RNF183 Q96D59 E3 ubiquitin-protein ligase RNF183 chr9 Not Cancer Driver No 1 hippie 22 29 1 1 0
SCGB1D1 SCGB1D1 O95968 Secretoglobin family 1D member 1 chr11 Not Cancer Driver No 1 hippie, biogrid 22 0 0 0 0
SDF4 SDF4 Q9BRK5 45 kDa calcium-binding protein chr1 Not Cancer Driver No 1 hippie 48 187 30 30 0
SELENOF_ENST00000616787 SELENOF O60613 Selenoprotein F chr1 Not Cancer Driver No 1 hippie 7 0 0 0 0
SETDB1 SETDB1 Q15047 Histone-lysine N-methyltransferase SETDB1 chr1 Census, Compendium Yes 1 hippie, biogrid 184 597 77 77 0
SFXN4 SFXN4 Q6P4A7 Sideroflexin-4 chr10 Not Cancer Driver No 1 hippie, biogrid 41 25 2 2 0
SGTA SGTA O43765 Small glutamine-rich tetratricopeptide repeat-containing protein alpha chr19 Not Cancer Driver No 1 intact 38 159 23 23 0
SLC43A3_ENST00000395124 SLC43A3 Q8NBI5 Equilibrative nucleobase transporter 1 chr11 Not Cancer Driver No 1 hippie, biogrid 75 32 2 2 0
SNX27 SNX27 Q96L92 Sorting nexin-27 chr1 Not Cancer Driver No 2 hippie, biogrid 65 120 9 9 0
SP110_ENST00000358662 SP110 Q9HB58 Sp110 nuclear body protein chr2 Not Cancer Driver No 1 hippie 92 368 54 54 0
SPRY4_ENST00000434127 SPRY4 Q9C004 Protein sprouty homolog 4 chr5 Not Cancer Driver No 1 hippie 34 134 20 20 7
ST13 ST13 P50502 Hsc70-interacting protein chr22 Not Cancer Driver No 1 hippie 38 297 29 29 0
ST3GAL3_ENST00000644195 ST3GAL3 Q11203 CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase chr1 Not Cancer Driver No 1 hippie 49 6 2 2 3
SUMF2_ENST00000275607 SUMF2 Q8NBJ7-2 Isoform 2 of Inactive C-alpha-formylglycine-generating enzyme 2 chr7 Not Cancer Driver No 1 hippie 27 75 12 12 0
SUMO3_ENST00000332859 SUMO3 P55854 Small ubiquitin-related modifier 3 chr21 Not Cancer Driver No 1 hippie 7 87 5 5 0
SYVN1 SYVN1 Q86TM6 E3 ubiquitin-protein ligase synoviolin chr11 Not Cancer Driver No 1 hippie 63 284 32 32 0
TAF1C TAF1C Q15572 TATA box-binding protein-associated factor RNA polymerase I subunit C chr16 Not Cancer Driver No 1 hippie 114 312 35 35 0
TAF5L TAF5L O75529 TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L chr1 Not Cancer Driver No 1 hippie 87 69 11 11 0
TBC1D22A TBC1D22A Q8WUA7 TBC1 domain family member 22A chr22 Not Cancer Driver No 1 hippie 84 219 23 23 0
TDG TDG Q13569 G/T mismatch-specific thymine DNA glycosylase chr12 Not Cancer Driver No 1 hippie 75 185 31 31 0
TF TF P02787 Serotransferrin chr3 Not Cancer Driver No 1 hippie 135 21 5 5 2
TGM2 TGM2 P21980 Protein-glutamine gamma-glutamyltransferase 2 chr20 Not Cancer Driver No 1 hippie 123 107 26 26 0
TMEM129_ENST00000536901 TMEM129 A0AVI4 E3 ubiquitin-protein ligase TM129 chr4 Not Cancer Driver No 1 hippie 15 8 1 1 0
TNFAIP3 TNFAIP3 P21580 Tumor necrosis factor alpha-induced protein 3 chr6 Census, Compendium Yes 1 hippie 98 231 33 33 1
TSSK2 TSSK2 Q96PF2 Testis-specific serine/threonine-protein kinase 2 chr22 Not Cancer Driver No 1 hippie, biogrid 50 91 11 11 0
TTR TTR P02766 Transthyretin chr18 Not Cancer Driver No 3 intact, hippie 28 25 8 8 75
TUBA1A TUBA1A Q71U36 Tubulin alpha-1A chain chr12 Not Cancer Driver No 1 hippie 59 52 11 11 8
UBE2E3_ENST00000602710 UBE2E3 Q969T4 Ubiquitin-conjugating enzyme E2 E3 chr2 Not Cancer Driver No 1 hippie 34 97 14 14 0
UBE2U_ENST00000611228 UBE2U Q5VVX9 Ubiquitin-conjugating enzyme E2 U chr1 Not Cancer Driver No 1 hippie, biogrid 38 66 1 1 0
UBL3 UBL3 O95164 Ubiquitin-like protein 3 chr13 Not Cancer Driver No 1 hippie 15 25 5 5 0
UBR1 UBR1 Q8IWV7 E3 ubiquitin-protein ligase UBR1 chr15 Not Cancer Driver No 1 hippie 170 165 15 15 18
VCP VCP P55072 Transitional endoplasmic reticulum ATPase chr9 Not Cancer Driver No 1 hippie 88 186 16 16 16
VDAC2_ENST00000543351 VDAC2 P45880 Voltage-dependent anion-selective channel protein 2 chr10 Not Cancer Driver No 1 hippie 35 9 1 1 0
VIM_ENST00000224237 VIM P08670 Vimentin chr10 Not Cancer Driver No 1 hippie, biogrid 84 316 57 57 1
VSX2 VSX2 P58304 Visual system homeobox 2 chr14 Not Cancer Driver No 1 hippie 43 268 23 23 5
VWA1 VWA1 Q6PCB0 von Willebrand factor A domain-containing protein 1 chr1 Not Cancer Driver No 1 hippie, biogrid 18 221 10 10 0
WDR83 WDR83 Q9BRX9 WD repeat domain-containing protein 83 chr19 Not Cancer Driver No 1 hippie 28 35 3 3 0
ZBED1 ZBED1 O96006 E3 SUMO-protein ligase ZBED1 chrX Not Cancer Driver No 1 hippie 137 97 12 12 0
ZXDC ZXDC Q2QGD7 Zinc finger protein ZXDC chr3 Not Cancer Driver No 1 hippie 81 551 49 49 0