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TTC4 ,TTC4 ,O95801
  • Uniprot Accession= O95801
  • Ensembl Transcript= ENST00000371281.3
  • Uniprot Name= TTC4
  • Name= Tetratricopeptide repeat protein 4
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 29
  • Number of Interaction partner in biogrid: 51
  • Number of Interaction partner in hippie: 86
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ACAD11 ACAD11 Q709F0 Acyl-CoA dehydrogenase family member 11 chr3 Not Cancer Driver No 1 intact, hippie 108 33 4 4 0
ACTR1A ACTR1A P61163 Alpha-centractin chr10 Not Cancer Driver No 1 hippie, biogrid 47 14 0 0 0
AHSA1 AHSA1 O95433 Activator of 90 kDa heat shock protein ATPase homolog 1 chr14 Not Cancer Driver No 1 hippie 46 146 17 17 0
APPL1 APPL1 Q9UKG1 DCC-interacting protein 13-alpha chr3 Not Cancer Driver No 1 hippie 67 292 31 31 1
ATG2A ATG2A Q2TAZ0 Autophagy-related protein 2 homolog A chr11 Not Cancer Driver No 1 intact 228 887 124 124 0
AURKA_ENST00000395915 AURKA O14965 Aurora kinase A chr20 Not Cancer Driver No 1 hippie, biogrid 36 178 21 21 0
BTBD2 BTBD2 Q9BX70 BTB/POZ domain-containing protein 2 chr19 Not Cancer Driver No 1 hippie, biogrid 46 118 2 2 0
CDC37 CDC37 Q16543 Hsp90 co-chaperone Cdc37 chr19 Not Cancer Driver No 1 intact, hippie 52 214 31 31 0
CDC37L1 CDC37L1 Q7L3B6 Hsp90 co-chaperone Cdc37-like 1 chr9 Not Cancer Driver No 1 intact, hippie 36 122 10 10 0
CDC6 CDC6 Q99741 Cell division control protein 6 homolog chr17 Not Cancer Driver No 1 intact, hippie 57 170 15 15 1
CHAMP1 CHAMP1 Q96JM3 Chromosome alignment-maintaining phosphoprotein 1 chr13 Not Cancer Driver No 1 hippie, biogrid 85 624 65 65 0
CHORDC1 CHORDC1 Q9UHD1 Cysteine and histidine-rich domain-containing protein 1 chr11 Not Cancer Driver No 2 hippie, biogrid 47 119 17 17 0
CHP1 CHP1 Q99653 Calcineurin B homologous protein 1 chr15 Not Cancer Driver No 1 intact 27 70 12 12 0
CTPS1 CTPS1 P17812 CTP synthase 1 chr1 Not Cancer Driver No 1 hippie, biogrid 70 83 10 10 0
CUL4A CUL4A Q13619 Cullin-4A chr13 Not Cancer Driver No 1 intact, hippie 64 102 2 2 0
DDI2 DDI2 Q5TDH0 Protein DDI1 homolog 2 chr1 Not Cancer Driver No 1 hippie, biogrid 47 187 30 30 0
DIAPH1 DIAPH1 O60610 Protein diaphanous homolog 1 chr5 Not Cancer Driver No 1 hippie, biogrid 118 692 57 57 1
DLD DLD P09622 Dihydrolipoyl dehydrogenase, mitochondrial chr7 Not Cancer Driver No 1 intact, hippie, biogrid 67 17 0 0 10
EDRF1 EDRF1 Q3B7T1 Erythroid differentiation-related factor 1 chr10 Not Cancer Driver No 4 intact, hippie, biogrid 139 270 36 36 0
EGLN3 EGLN3 Q9H6Z9 Prolyl hydroxylase EGLN3 chr14 Not Cancer Driver No 1 hippie 33 13 0 0 0
EP300 EP300 Q09472 Histone acetyltransferase p300 chr22 Census, Compendium Yes 1 hippie 334 1790 196 196 1
EPB41L5 EPB41L5 Q9HCM4 Band 4.1-like protein 5 chr2 Not Cancer Driver No 1 hippie, biogrid 97 312 45 45 0
FAM120C FAM120C Q9NX05 Constitutive coactivator of PPAR-gamma-like protein 2 chrX Not Cancer Driver No 1 hippie 162 508 77 77 0
FBXO32 FBXO32 Q969P5 F-box only protein 32 chr8 Not Cancer Driver No 1 hippie 54 0 0 0 0
FBXO6 FBXO6 Q9NRD1 F-box only protein 6 chr1 Not Cancer Driver No 1 hippie 31 27 3 3 0
FGFR3_ENST00000440486 FGFR3 P22607 Fibroblast growth factor receptor 3 chr4 Census, Compendium Yes 1 intact 173 241 26 26 37
FKBP5 FKBP5 Q13451 Peptidyl-prolyl cis-trans isomerase FKBP5 chr6 Not Cancer Driver No 1 intact, hippie 70 150 20 20 0
GCC2 GCC2 Q8IWJ2 GRIP and coiled-coil domain-containing protein 2 chr2 Not Cancer Driver No 3 intact, hippie, biogrid 178 999 113 113 0
GFER GFER P55789 FAD-linked sulfhydryl oxidase ALR chr16 Not Cancer Driver No 1 biogrid 10 97 4 4 1
GIP GIP P09681 Gastric inhibitory polypeptide chr17 Not Cancer Driver No 1 hippie, biogrid 35 68 16 16 0
GLE1 GLE1 Q53GS7 mRNA export factor GLE1 chr9 Not Cancer Driver No 1 hippie 64 299 29 29 3
GRK6_ENST00000355472 GRK6 P43250 G protein-coupled receptor kinase 6 chr5 Not Cancer Driver No 1 hippie, biogrid 65 68 10 10 0
HAT1 HAT1 O14929 Histone acetyltransferase type B catalytic subunit chr2 Not Cancer Driver No 1 hippie, biogrid 51 14 2 2 0
HDLBP_ENST00000391976 HDLBP Q00341 Vigilin chr2 Not Cancer Driver No 1 hippie, biogrid 195 555 87 87 0
HGH1 HGH1 Q9BTY7 Protein HGH1 homolog chr8 Not Cancer Driver No 4 intact, hippie, biogrid 3 106 1 1 0
HGS HGS O14964 Hepatocyte growth factor-regulated tyrosine kinase substrate chr17 Not Cancer Driver No 1 hippie 109 528 74 74 0
HPS5 HPS5 Q9UPZ3 Hermansky-Pudlak syndrome 5 protein chr11 Not Cancer Driver No 1 hippie, biogrid 116 236 17 17 2
HSCB HSCB Q8IWL3 Iron-sulfur cluster co-chaperone protein HscB chr22 Not Cancer Driver No 2 intact, hippie, biogrid 36 25 6 6 0
HSP90AA1_ENST00000216281 HSP90AA1 P07900 Heat shock protein HSP 90-alpha chr14 Census, Compendium Yes 2 intact, hippie 106 257 37 37 0
HSP90AB1 HSP90AB1 P08238 Heat shock protein HSP 90-beta chr6 Census, Compendium Yes 2 intact, hippie 100 254 43 43 0
HSPA4L_ENST00000508776 HSPA4L O95757 Heat shock 70 kDa protein 4L chr4 Not Cancer Driver No 1 hippie, biogrid 105 266 28 28 0
HSPA8_ENST00000532636 HSPA8 P11142 Heat shock cognate 71 kDa protein chr11 Not Cancer Driver No 1 intact, hippie 149 251 52 52 0
KAT6A_ENST00000406337 KAT6A Q92794 Histone acetyltransferase KAT6A chr8 Census, Compendium Yes 1 hippie 273 1420 193 193 0
LCK LCK P06239 Tyrosine-protein kinase Lck chr1 Census Yes 1 hippie, biogrid 86 94 13 13 1
LMAN1 LMAN1 P49257 Protein ERGIC-53 chr18 Not Cancer Driver No 1 hippie, biogrid 63 222 25 25 1
LRRK2 LRRK2 Q5S007 Leucine-rich repeat serine/threonine-protein kinase 2 chr12 Not Cancer Driver No 1 intact, hippie 519 90 17 17 23
MFN2_ENST00000444836 MFN2 O95140 Mitofusin-2 chr1 Not Cancer Driver No 1 hippie, biogrid 80 81 9 9 20
MTRF1L MTRF1L Q9UGC7 Peptide chain release factor 1-like, mitochondrial chr6 Not Cancer Driver No 1 hippie, biogrid 31 183 12 12 0
NEK8 NEK8 Q86SG6 Serine/threonine-protein kinase Nek8 chr17 Not Cancer Driver No 1 intact, hippie 102 167 40 40 3
NOX5 NOX5 Q96PH1 NADPH oxidase 5 chr15 Not Cancer Driver No 2 intact, hippie, biogrid 118 95 9 9 0
NPHP4 NPHP4 O75161 Nephrocystin-4 chr1 Not Cancer Driver No 1 intact, hippie 176 469 54 54 17
NRAS NRAS P01111 GTPase NRas chr1 Census, Compendium Yes 1 hippie 284 10 0 0 14
NSMCE1 NSMCE1 Q8WV22 Non-structural maintenance of chromosomes element 1 homolog chr16 Not Cancer Driver No 1 biogrid 40 31 8 8 0
OGT OGT O15294 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit chrX Not Cancer Driver No 1 hippie 156 89 16 16 2
PCID2_ENST00000375479 PCID2 Q5JVF3 PCI domain-containing protein 2 chr13 Not Cancer Driver No 1 hippie, biogrid 46 13 5 5 0
PLEKHA4 PLEKHA4 Q9H4M7 Pleckstrin homology domain-containing family A member 4 chr19 Not Cancer Driver No 1 hippie 136 687 128 128 0
PTGES3_ENST00000262033 PTGES3 Q15185 Prostaglandin E synthase 3 chr12 Not Cancer Driver No 1 hippie, biogrid 11 52 3 3 0
RECQL4 RECQL4 O94761 ATP-dependent DNA helicase Q4 chr8 Census, Compendium Yes 1 hippie 138 608 71 71 1
RELCH RELCH Q9P260 RAB11-binding protein RELCH chr18 Not Cancer Driver No 1 hippie 114 384 29 29 0
RET RET P07949 Proto-oncogene tyrosine-protein kinase receptor Ret chr10 Census, Compendium Yes 1 intact 208 105 12 12 139
RXFP4 RXFP4 Q8TDU9 Relaxin-3 receptor 2 chr1 Not Cancer Driver No 1 intact, hippie 39 15 1 1 0
S100A9 S100A9 P06702 Protein S100-A9 chr1 Not Cancer Driver No 1 hippie, biogrid 18 76 7 7 0
SAC3D1 SAC3D1 F8WC89 SAC3 domain-containing protein 1 chr11 Not Cancer Driver No 1 hippie, biogrid 25 96 6 6 0
SERPINB13_ENST00000344731 SERPINB13 Q9UIV8 Serpin B13 chr18 Not Cancer Driver No 2 intact, hippie, biogrid 84 55 16 16 0
SF3A3 SF3A3 Q12874 Splicing factor 3A subunit 3 chr1 Not Cancer Driver No 1 hippie, biogrid 63 182 19 19 0
SLC27A6_ENST00000395266 SLC27A6 Q9Y2P4 Long-chain fatty acid transport protein 6 chr5 Not Cancer Driver No 2 hippie, biogrid 187 2 1 1 0
SLK SLK Q9H2G2 STE20-like serine/threonine-protein kinase chr10 Not Cancer Driver No 1 hippie 134 962 96 96 0
SNAPC1 SNAPC1 Q16533 snRNA-activating protein complex subunit 1 chr14 Not Cancer Driver No 1 biogrid 36 158 16 16 0
SNAPC3_ENST00000610884 SNAPC3 Q92966 snRNA-activating protein complex subunit 3 chr9 Not Cancer Driver No 1 intact, hippie 30 99 2 2 0
SRSF2 SRSF2 Q01130 Serine/arginine-rich splicing factor 2 chr17 Census, Compendium Yes 1 hippie, biogrid 38 219 38 38 0
STK26 STK26 Q9P289 Serine/threonine-protein kinase 26 chrX Not Cancer Driver No 1 hippie, biogrid 62 119 18 18 0
TBK1 TBK1 Q9UHD2 Serine/threonine-protein kinase TBK1 chr12 Not Cancer Driver No 1 intact, hippie 101 42 5 5 12
TCOF1 TCOF1 Q13428 Treacle protein chr5 Not Cancer Driver No 1 intact, hippie 142 1454 141 141 1
TLN2 TLN2 Q9Y4G6 Talin-2 chr15 Not Cancer Driver No 1 hippie, biogrid 336 892 123 123 0
TMOD4 TMOD4 Q9NZQ9 Tropomodulin-4 chr1 Not Cancer Driver No 1 intact, hippie 37 218 22 22 0
TRIM25 TRIM25 Q14258 E3 ubiquitin/ISG15 ligase TRIM25 chr17 Not Cancer Driver No 1 hippie 59 225 20 20 0
TRIM56 TRIM56 Q9BRZ2 E3 ubiquitin-protein ligase TRIM56 chr7 Not Cancer Driver No 1 hippie 110 217 36 36 0
TRIP13 TRIP13 Q15645 Pachytene checkpoint protein 2 homolog chr5 Not Cancer Driver No 1 hippie, biogrid 62 30 6 6 1
TRMT6 TRMT6 Q9UJA5 tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 chr20 Not Cancer Driver No 1 hippie, biogrid 42 208 17 17 0
TSN TSN Q15631 Translin chr2 Not Cancer Driver No 1 hippie, biogrid 30 0 0 0 0
TTC4 TTC4 O95801 Tetratricopeptide repeat protein 4 chr1 Not Cancer Driver No 1 biogrid 45 100 12 12 0
TUBA1A TUBA1A Q71U36 Tubulin alpha-1A chain chr12 Not Cancer Driver No 1 intact, hippie 59 52 11 11 8
TUBA4A TUBA4A P68366 Tubulin alpha-4A chain chr2 Not Cancer Driver No 1 hippie, biogrid 73 39 4 4 5
TULP3_ENST00000448120 TULP3 O75386 Tubby-related protein 3 chr12 Not Cancer Driver No 1 hippie 66 218 29 29 0
TXLNG TXLNG Q9NUQ3 Gamma-taxilin chrX Not Cancer Driver No 1 hippie, biogrid 50 374 35 35 0
UBE2S UBE2S Q16763 Ubiquitin-conjugating enzyme E2 S chr19 Not Cancer Driver No 1 hippie, biogrid 25 102 12 12 0
UBE4B UBE4B O95155 Ubiquitin conjugation factor E4 B chr1 Not Cancer Driver No 1 hippie, biogrid 158 434 49 49 0
UPF1 UPF1 Q92900 Regulator of nonsense transcripts 1 chr19 Not Cancer Driver No 1 hippie, biogrid 146 329 36 36 0
VCP VCP P55072 Transitional endoplasmic reticulum ATPase chr9 Not Cancer Driver No 1 hippie 88 186 16 16 16
VPS26A_ENST00000263559 VPS26A O75436 Vacuolar protein sorting-associated protein 26A chr10 Not Cancer Driver No 2 hippie, biogrid 27 44 2 2 0
VPS29_ENST00000549578 VPS29 Q9UBQ0 Vacuolar protein sorting-associated protein 29 chr12 Not Cancer Driver No 2 hippie, biogrid 24 0 0 0 0
VPS35 VPS35 Q96QK1 Vacuolar protein sorting-associated protein 35 chr16 Not Cancer Driver No 2 hippie, biogrid 68 99 9 9 1
VPS36 VPS36 Q86VN1 Vacuolar protein-sorting-associated protein 36 chr13 Not Cancer Driver No 1 hippie, biogrid 35 94 14 14 0
WWOX WWOX Q9NZC7 WW domain-containing oxidoreductase chr16 Not Cancer Driver No 1 hippie 79 108 9 9 3