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TPR ,TPR ,P12270
  • Uniprot Accession= P12270
  • Ensembl Transcript= ENST00000367478.8
  • Uniprot Name= TPR
  • Name= Nucleoprotein TPR
  • Chromosome= chr1
  • Driver status= Census
  • Number of Interaction partner in intact: 31
  • Number of Interaction partner in biogrid: 49
  • Number of Interaction partner in hippie: 253
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ABCC12 ABCC12 Q96J65 ATP-binding cassette sub-family C member 12 chr16 Not Cancer Driver No 1 intact, hippie 247 116 16 16 0
ACLY_ENST00000590151 ACLY P53396 ATP-citrate synthase chr17 Not Cancer Driver No 1 hippie 120 114 12 12 0
ACTC1 ACTC1 P68032 Actin, alpha cardiac muscle 1 chr15 Not Cancer Driver No 1 hippie 114 48 19 19 11
ADCY10 ADCY10 Q96PN6 Adenylate cyclase type 10 chr1 Not Cancer Driver No 1 hippie 249 24 4 4 0
ANXA1_ENST00000257497 ANXA1 P04083 Annexin A1 chr9 Not Cancer Driver No 1 hippie 59 61 12 12 0
AP1G1_ENST00000569748 AP1G1 O43747 AP-1 complex subunit gamma-1 chr16 Not Cancer Driver No 1 hippie 111 144 22 22 0
APC APC P25054 Adenomatous polyposis coli protein chr5 Census, Compendium Yes 1 intact, hippie 412 2406 345 345 22
ARID1A ARID1A O14497 AT-rich interactive domain-containing protein 1A chr1 Census, Compendium Yes 1 hippie 275 1856 206 206 0
ATL3 ATL3 Q6DD88 Atlastin-3 chr11 Not Cancer Driver No 1 hippie, biogrid 43 57 5 5 1
ATP5F1B ATP5F1B P06576 ATP synthase subunit beta, mitochondrial chr12 Not Cancer Driver No 1 hippie 60 85 8 8 0
BCCIP_ENST00000278100 BCCIP Q9P287 BRCA2 and CDKN1A-interacting protein chr10 Not Cancer Driver No 1 hippie 35 99 16 16 0
BCL2L1 BCL2L1 Q07817 Bcl-2-like protein 1 chr20 Not Cancer Driver No 1 hippie 29 55 3 3 0
BEX3_ENST00000372635 BEX3 Q00994 Protein BEX3 chrX Not Cancer Driver No 1 hippie 19 98 17 17 0
BIRC3_ENST00000532808 BIRC3 Q13489 Baculoviral IAP repeat-containing protein 3 chr11 Census, Compendium Yes 1 hippie 77 98 16 16 0
BRCA1_ENST00000357654 BRCA1 P38398 Breast cancer type 1 susceptibility protein chr17 Census, Compendium Yes 1 hippie 224 1458 174 174 35
BRD4 BRD4 O60885 Bromodomain-containing protein 4 chr19 Census, Compendium Yes 1 hippie 193 1182 172 172 0
BUD31 BUD31 P41223 Protein BUD31 homolog chr7 Not Cancer Driver No 1 hippie, biogrid 20 32 4 4 0
CANX_ENST00000504734 CANX P27824 Calnexin chr5 Not Cancer Driver No 1 intact, hippie 65 334 38 38 0
CAPNS1 CAPNS1 P04632 Calpain small subunit 1 chr19 Not Cancer Driver No 1 hippie 30 58 5 5 0
CBX7 CBX7 O95931 Chromobox protein homolog 7 chr22 Not Cancer Driver No 1 intact, hippie 40 175 34 34 0
CCDC8 CCDC8 Q9H0W5 Coiled-coil domain-containing protein 8 chr19 Not Cancer Driver No 1 hippie 96 505 91 91 0
CD274 CD274 Q9NZQ7 Programmed cell death 1 ligand 1 chr9 Census Yes 1 hippie 29 54 9 9 0
CDC20 CDC20 Q12834 Cell division cycle protein 20 homolog chr1 Not Cancer Driver No 1 intact, hippie 44 198 15 15 0
CDC5L CDC5L Q99459 Cell division cycle 5-like protein chr6 Not Cancer Driver No 1 intact, hippie 100 618 77 77 0
CDK7 CDK7 P50613 Cyclin-dependent kinase 7 chr5 Not Cancer Driver No 1 intact, hippie 41 38 5 5 0
CDK9 CDK9 P50750 Cyclin-dependent kinase 9 chr9 Not Cancer Driver No 1 hippie 50 34 2 2 0
CDKN3 CDKN3 Q16667 Cyclin-dependent kinase inhibitor 3 chr14 Not Cancer Driver No 1 hippie 13 33 1 1 9
CEP164 CEP164 Q9UPV0 Centrosomal protein of 164 kDa chr11 Not Cancer Driver No 1 hippie 161 1198 124 124 2
CFTR CFTR P13569 Cystic fibrosis transmembrane conductance regulator chr7 Not Cancer Driver No 1 hippie 287 145 18 18 151
CGN CGN Q9P2M7 Cingulin chr1 Not Cancer Driver No 1 hippie 152 1179 149 149 0
CHD4 CHD4 Q14839 Chromodomain-helicase-DNA-binding protein 4 chr12 Census, Compendium Yes 1 hippie 419 974 177 177 6
CHEK2_ENST00000405598 CHEK2 O96017 Serine/threonine-protein kinase Chk2 chr22 Census, Compendium Yes 1 intact, hippie 335 157 130 130 13
CIRBP_ENST00000586472 CIRBP Q14011 Cold-inducible RNA-binding protein chr19 Not Cancer Driver No 1 hippie, biogrid 19 129 13 13 0
CIT_ENST00000261833 CIT O14578 Citron Rho-interacting kinase chr12 Not Cancer Driver No 1 hippie 284 1017 160 160 3
CLTC_ENST00000269122 CLTC Q00610 Clathrin heavy chain 1 chr17 Census, Compendium Yes 1 hippie 190 71 6 6 1
CLU_ENST00000523500 CLU P10909 Clusterin chr8 Not Cancer Driver No 1 hippie 69 156 27 27 0
CNOT3 CNOT3 O75175 CCR4-NOT transcription complex subunit 3 chr19 Census, Compendium Yes 1 hippie 120 538 78 78 4
CNTROB_ENST00000563694 CNTROB Q8N137 Centrobin chr17 Not Cancer Driver No 1 hippie 97 837 93 93 0
COL5A3 COL5A3 P25940 Collagen alpha-3(V) chain chr19 Not Cancer Driver No 1 hippie 365 1427 311 311 0
COP1 COP1 Q8NHY2 E3 ubiquitin-protein ligase COP1 chr1 Not Cancer Driver No 1 hippie 106 147 11 11 0
CSE1L CSE1L P55060 Exportin-2 chr20 Not Cancer Driver No 1 hippie 109 32 5 5 0
CTNNBIP1_ENST00000377258 CTNNBIP1 Q9NSA3 Beta-catenin-interacting protein 1 chr1 Not Cancer Driver No 1 hippie 8 64 7 7 0
CUL4A CUL4A Q13619 Cullin-4A chr13 Not Cancer Driver No 1 hippie 64 102 2 2 0
CUL7_ENST00000265348 CUL7 Q14999 Cullin-7 chr6 Not Cancer Driver No 1 hippie 188 372 41 41 3
DAB2IP_ENST00000408936 DAB2IP Q5VWQ8 Disabled homolog 2-interacting protein chr9 Not Cancer Driver No 1 hippie 131 681 68 68 0
DCLK1 DCLK1 O15075 Serine/threonine-protein kinase DCLK1 chr13 Not Cancer Driver No 1 hippie 209 252 77 77 0
DCPS DCPS Q96C86 m7GpppX diphosphatase chr11 Not Cancer Driver No 1 hippie 48 53 6 6 1
DDB1 DDB1 Q16531 DNA damage-binding protein 1 chr11 Not Cancer Driver No 1 biogrid 126 50 8 8 4
DDX1 DDX1 Q92499 ATP-dependent RNA helicase DDX1 chr2 Not Cancer Driver No 1 hippie, biogrid 82 91 15 15 0
DDX27 DDX27 Q96GQ7 Probable ATP-dependent RNA helicase DDX27 chr20 Not Cancer Driver No 1 hippie 101 383 50 50 0
DDX3X_ENST00000629496 DDX3X O00571 ATP-dependent RNA helicase DDX3X chrX Census, Compendium Yes 1 hippie, biogrid 133 301 47 47 18
DDX58 DDX58 O95786 Antiviral innate immune response receptor RIG-I chr9 Not Cancer Driver No 1 hippie 118 61 10 10 2
DOCK8 DOCK8 Q8NF50 Dedicator of cytokinesis protein 8 chr9 Not Cancer Driver No 1 intact, hippie, biogrid 321 312 60 60 1
DRAP1 DRAP1 Q14919 Dr1-associated corepressor chr11 Not Cancer Driver No 1 hippie 28 170 22 22 0
DSP DSP P15924 Desmoplakin chr6 Not Cancer Driver No 1 hippie 483 1124 204 204 6
DUSP19 DUSP19 Q8WTR2 Dual specificity protein phosphatase 19 chr2 Not Cancer Driver No 1 intact, hippie 34 15 5 5 0
DUSP7 DUSP7 Q16829 Dual specificity protein phosphatase 7 chr3 Not Cancer Driver No 1 hippie 40 139 5 5 0
DYRK1A_ENST00000644942 DYRK1A Q13627 Dual specificity tyrosine-phosphorylation-regulated kinase 1A chr21 Not Cancer Driver No 1 hippie 135 447 73 73 0
DZIP1_ENST00000376829 DZIP1 Q86YF9 Cilium assembly protein DZIP1 chr13 Not Cancer Driver No 1 hippie 143 523 92 92 2
EED_ENST00000263360 EED O75530 Polycomb protein EED chr11 Census Yes 1 hippie 64 79 11 11 6
EEF1B2_ENST00000236957 EEF1B2 P24534 Elongation factor 1-beta chr2 Not Cancer Driver No 1 hippie, biogrid 63 71 11 11 0
EEF1D_ENST00000395119 EEF1D P29692 Elongation factor 1-delta chr8 Not Cancer Driver No 2 hippie, biogrid 40 153 22 22 0
EFTUD2 EFTUD2 Q15029 116 kDa U5 small nuclear ribonucleoprotein component chr17 Compendium Yes 1 hippie, biogrid 132 179 30 30 3
EIF1AX EIF1AX P47813 Eukaryotic translation initiation factor 1A, X-chromosomal chrX Census, Compendium Yes 1 hippie 39 67 28 28 0
EIF2B5 EIF2B5 Q13144 Translation initiation factor eIF-2B subunit epsilon chr3 Not Cancer Driver No 1 hippie 76 179 16 16 29
ELMO2_ENST00000396391 ELMO2 Q96JJ3 Engulfment and cell motility protein 2 chr20 Not Cancer Driver No 1 hippie 82 101 9 9 0
EMC1 EMC1 Q8N766 ER membrane protein complex subunit 1 chr1 Not Cancer Driver No 1 hippie 107 59 6 6 2
EPAS1 EPAS1 Q99814 Endothelial PAS domain-containing protein 1 chr2 Census, Compendium Yes 1 hippie 120 449 53 53 6
ERCC6 ERCC6 Q03468 DNA excision repair protein ERCC-6 chr10 Not Cancer Driver No 1 hippie 211 829 117 117 9
FAM13C FAM13C Q8NE31 Protein FAM13C chr10 Not Cancer Driver No 1 hippie 139 527 128 128 0
FANCD2_ENST00000383807 FANCD2 Q9BXW9 Fanconi anemia group D2 protein chr3 Census, Compendium Yes 1 hippie 176 181 14 14 3
FN1 FN1 P02751 Fibronectin chr2 Compendium Yes 1 intact, hippie 394 1243 185 185 8
FNBP1 FNBP1 Q96RU3 Formin-binding protein 1 chr9 Census Yes 1 hippie 91 460 75 75 0
FOS FOS P01100 Protein c-Fos chr14 Not Cancer Driver No 1 hippie 45 245 33 33 0
FOXK2 FOXK2 Q01167 Forkhead box protein K2 chr17 Not Cancer Driver No 1 hippie 79 548 64 64 0
FYCO1 FYCO1 Q9BQS8 FYVE and coiled-coil domain-containing protein 1 chr3 Not Cancer Driver No 1 hippie 181 892 106 106 1
GBA2 GBA2 Q9HCG7 Non-lysosomal glucosylceramidase chr9 Not Cancer Driver No 1 hippie 96 157 12 12 3
GBF1 GBF1 Q92538 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 chr10 Not Cancer Driver No 1 hippie 216 669 76 76 0
GLRX_ENST00000505427 GLRX P35754 Glutaredoxin-1 chr5 Not Cancer Driver No 1 hippie, biogrid 14 0 0 0 0
GOLGA3_ENST00000450791 GOLGA3 Q08378 Golgin subfamily A member 3 chr12 Not Cancer Driver No 1 hippie 221 1272 189 189 0
GTF2E2 GTF2E2 P29084 Transcription initiation factor IIE subunit beta chr8 Not Cancer Driver No 1 hippie, biogrid 34 130 16 16 2
HAUS3 HAUS3 Q68CZ6 HAUS augmin-like complex subunit 3 chr4 Not Cancer Driver No 1 hippie 61 55 7 7 0
HDAC4 HDAC4 P56524 Histone deacetylase 4 chr2 Not Cancer Driver No 1 hippie 182 749 132 132 0
HDAC9_ENST00000432645 HDAC9 Q9UKV0 Histone deacetylase 9 chr7 Not Cancer Driver No 1 hippie, biogrid 286 631 178 178 0
HNRNPA2B1 HNRNPA2B1 P22626 Heterogeneous nuclear ribonucleoproteins A2/B1 chr7 Census, Compendium Yes 1 hippie, biogrid 68 255 41 41 0
HNRNPU HNRNPU Q00839 Heterogeneous nuclear ribonucleoprotein U chr1 Not Cancer Driver No 1 hippie, biogrid 77 504 45 45 0
HRAS HRAS P01112 GTPase HRas chr11 Census, Compendium Yes 1 hippie, biogrid 107 16 4 4 18
HTT HTT P42858 Huntingtin chr4 Not Cancer Driver No 1 hippie 336 666 69 69 2
IFI16_ENST00000295809 IFI16 Q16666 Gamma-interferon-inducible protein 16 chr1 Not Cancer Driver No 1 hippie 155 419 90 90 0
IK IK Q13123 Protein Red chr5 Not Cancer Driver No 2 hippie, biogrid 61 482 50 50 0
IQCD IQCD Q96DY2 Dynein regulatory complex protein 10 chr12 Not Cancer Driver No 1 hippie 49 188 25 25 0
ITGA4 ITGA4 P13612 Integrin alpha-4 chr2 Not Cancer Driver No 1 hippie 254 97 27 27 0
ITPRID2 ITPRID2 P28290 Protein ITPRID2 chr2 Not Cancer Driver No 1 hippie 158 1006 129 129 0
JUN JUN P05412 Transcription factor Jun chr1 Census Yes 1 hippie 35 281 25 25 0
KANK1_ENST00000382303 KANK1 Q14678 KN motif and ankyrin repeat domain-containing protein 1 chr9 Not Cancer Driver No 1 hippie 183 804 100 100 0
KAT8_ENST00000219797 KAT8 Q9H7Z6 Histone acetyltransferase KAT8 chr16 Not Cancer Driver No 1 hippie 66 156 20 20 4
KIAA1328 KIAA1328 Q86T90 Protein hinderin chr18 Not Cancer Driver No 1 hippie 77 442 66 66 0
KIF1B_ENST00000377086 KIF1B O60333 Kinesin-like protein KIF1B chr1 Not Cancer Driver No 1 hippie 253 633 106 106 1
KIFC2 KIFC2 Q96AC6 Kinesin-like protein KIFC2 chr8 Not Cancer Driver No 1 hippie 84 605 55 55 0
KPNB1 KPNB1 Q14974 Importin subunit beta-1 chr17 Not Cancer Driver No 1 hippie 92 94 11 11 0
KRT8_ENST00000546897 KRT8 P05787 Keratin, type II cytoskeletal 8 chr12 Not Cancer Driver No 1 hippie 65 221 37 37 3
LENG8 LENG8 Q96PV6 Leukocyte receptor cluster member 8 chr19 Not Cancer Driver No 1 hippie 137 515 97 97 0
LGR4 LGR4 Q9BXB1 Leucine-rich repeat-containing G-protein coupled receptor 4 chr11 Not Cancer Driver No 1 hippie 108 16 3 3 0
LMNA LMNA P02545 Prelamin-A/C chr1 Census Yes 2 intact, hippie 68 544 49 49 131
LPIN2 LPIN2 Q92539 Phosphatidate phosphatase LPIN2 chr18 Not Cancer Driver No 1 hippie 113 455 56 56 1
LRRFIP2 LRRFIP2 Q9Y608 Leucine-rich repeat flightless-interacting protein 2 chr3 Not Cancer Driver No 1 hippie 75 584 62 62 0
LRRK2 LRRK2 Q5S007 Leucine-rich repeat serine/threonine-protein kinase 2 chr12 Not Cancer Driver No 2 intact, hippie 519 90 17 17 23
MAD1L1_ENST00000399654 MAD1L1 Q9Y6D9 Mitotic spindle assembly checkpoint protein MAD1 chr7 Not Cancer Driver No 1 hippie 117 526 77 77 0
MAD2L1 MAD2L1 Q13257 Mitotic spindle assembly checkpoint protein MAD2A chr4 Not Cancer Driver No 1 hippie, biogrid 26 12 1 1 0
MAP1LC3A_ENST00000397709 MAP1LC3A Q9H492 Microtubule-associated proteins 1A/1B light chain 3A chr20 Not Cancer Driver No 1 hippie 22 24 1 1 0
MAP2K1 MAP2K1 Q02750 Dual specificity mitogen-activated protein kinase kinase 1 chr15 Census, Compendium Yes 1 hippie 94 96 24 24 6
MAP3K4 MAP3K4 Q9Y6R4 Mitogen-activated protein kinase kinase kinase 4 chr6 Not Cancer Driver No 1 hippie 261 520 86 86 0
MAP9 MAP9 Q49MG5 Microtubule-associated protein 9 chr4 Not Cancer Driver No 1 intact, hippie 118 622 116 116 0
MAPK1_ENST00000398822 MAPK1 P28482 Mitogen-activated protein kinase 1 chr22 Census, Compendium Yes 1 hippie 62 2 0 0 7
MCM2 MCM2 P49736 DNA replication licensing factor MCM2 chr3 Not Cancer Driver No 1 hippie 104 275 38 38 1
MCM3_ENST00000229854 MCM3 P25205 DNA replication licensing factor MCM3 chr6 Not Cancer Driver No 1 hippie 92 310 47 47 0
MDM2_ENST00000539479 MDM2 Q00987 E3 ubiquitin-protein ligase Mdm2 chr12 Census, Compendium Yes 1 hippie 56 297 37 37 0
MED28 MED28 Q9H204 Mediator of RNA polymerase II transcription subunit 28 chr4 Not Cancer Driver No 1 hippie 24 101 18 18 0
METAP2 METAP2 P50579 Methionine aminopeptidase 2 chr12 Not Cancer Driver No 1 hippie 54 176 19 19 0
MIA3 MIA3 Q5JRA6 Transport and Golgi organization protein 1 homolog chr1 Not Cancer Driver No 1 hippie 222 1490 178 178 0
MMP8 MMP8 P22894 Neutrophil collagenase chr11 Not Cancer Driver No 1 hippie 73 115 19 19 0
MNT MNT Q99583 Max-binding protein MNT chr17 Not Cancer Driver No 1 intact, hippie 57 542 56 56 0
MRE11 MRE11 P49959 Double-strand break repair protein MRE11 chr11 Not Cancer Driver No 1 hippie 84 292 35 35 1
MYC_ENST00000377970 MYC P01106 Myc proto-oncogene protein chr8 Census, Compendium Yes 1 hippie 80 299 46 46 0
MYL12B_ENST00000237500 MYL12B O14950 Myosin regulatory light chain 12B chr18 Not Cancer Driver No 1 hippie 23 61 13 13 0
NAA40 NAA40 Q86UY6 N-alpha-acetyltransferase 40 chr11 Not Cancer Driver No 1 hippie 22 30 3 3 0
NAMPT NAMPT P43490 Nicotinamide phosphoribosyltransferase chr7 Not Cancer Driver No 1 hippie 50 27 5 5 0
NAPA NAPA P54920 Alpha-soluble NSF attachment protein chr19 Not Cancer Driver No 1 hippie 33 11 0 0 0
NCOA3 NCOA3 Q9Y6Q9 Nuclear receptor coactivator 3 chr20 Not Cancer Driver No 1 hippie 176 1231 160 160 0
NDN NDN Q99608 Necdin chr15 Not Cancer Driver No 1 hippie 123 117 42 42 0
NDUFB7 NDUFB7 P17568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 chr19 Not Cancer Driver No 1 intact, hippie 17 65 6 6 0
NF2 NF2 P35240 Merlin chr22 Census, Compendium Yes 1 hippie 69 252 26 26 16
NFKB1_ENST00000505458 NFKB1 P19838 Nuclear factor NF-kappa-B p105 subunit chr4 Not Cancer Driver No 1 hippie 104 344 38 38 0
NFXL1 NFXL1 Q6ZNB6 NF-X1-type zinc finger protein NFXL1 chr4 Not Cancer Driver No 1 intact, hippie 102 183 15 15 0
NIN NIN Q8N4C6 Ninein chr14 Census, Compendium Yes 1 hippie 239 1392 164 164 2
NPM1 NPM1 P06748 Nucleophosmin chr5 Census, Compendium Yes 1 hippie 29 249 22 22 0
NPY2R NPY2R P49146 Neuropeptide Y receptor type 2 chr4 Not Cancer Driver No 1 intact, hippie 119 53 16 16 0
NSD2_ENST00000382892 NSD2 O96028 Histone-lysine N-methyltransferase NSD2 chr4 Census, Compendium Yes 1 hippie 191 552 76 76 0
NTRK1 NTRK1 P04629 High affinity nerve growth factor receptor chr1 Census, Compendium Yes 1 hippie 168 57 8 8 25
NUP107 NUP107 P57740 Nuclear pore complex protein Nup107 chr12 Not Cancer Driver No 3 intact, hippie, biogrid 127 183 26 26 5
NUP153_ENST00000262077 NUP153 P49790 Nuclear pore complex protein Nup153 chr6 Not Cancer Driver No 1 hippie 180 1152 147 147 0
NUP205 NUP205 Q92621 Nuclear pore complex protein Nup205 chr7 Not Cancer Driver No 1 hippie 251 101 16 16 1
NUP37_ENST00000251074 NUP37 Q8NFH4 Nucleoporin Nup37 chr12 Not Cancer Driver No 1 hippie 39 0 0 0 0
NUP93 NUP93 Q8N1F7 Nuclear pore complex protein Nup93 chr16 Not Cancer Driver No 1 hippie 97 158 23 23 3
NUP98_ENST00000359171 NUP98 P52948 Nuclear pore complex protein Nup98-Nup96 chr11 Census Yes 1 hippie 227 1008 107 107 0
NUPR1_ENST00000324873 NUPR1 O60356 Nuclear protein 1 chr16 Not Cancer Driver No 1 hippie 10 82 10 10 0
NXF1_ENST00000294172 NXF1 Q9UBU9 Nuclear RNA export factor 1 chr11 Compendium Yes 2 hippie, biogrid 100 163 32 32 0
OBSCN_ENST00000422127 OBSCN Q5VST9 Obscurin chr1 Not Cancer Driver No 1 hippie 1208 2623 368 368 0
OBSL1 OBSL1 O75147 Obscurin-like protein 1 chr2 Not Cancer Driver No 1 hippie 233 553 60 60 0
OCRL OCRL Q01968 Inositol polyphosphate 5-phosphatase OCRL chrX Not Cancer Driver No 1 hippie 151 126 24 24 41
PACSIN1_ENST00000244458 PACSIN1 Q9BY11 Protein kinase C and casein kinase substrate in neurons protein 1 chr6 Not Cancer Driver No 1 hippie 56 318 47 47 0
PCCB_ENST00000251654 PCCB P05166 Propionyl-CoA carboxylase beta chain, mitochondrial chr3 Not Cancer Driver No 1 intact, hippie 59 64 12 12 25
PCLAF PCLAF Q15004 PCNA-associated factor chr15 Not Cancer Driver No 1 hippie 20 111 20 20 0
PDCD4 PDCD4 Q53EL6 Programmed cell death protein 4 chr10 Not Cancer Driver No 1 hippie 57 187 32 32 0
PDHA1_ENST00000422285 PDHA1 P08559 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial chrX Not Cancer Driver No 1 hippie, biogrid 70 43 6 6 20
PDZRN3 PDZRN3 Q9UPQ7 E3 ubiquitin-protein ligase PDZRN3 chr3 Not Cancer Driver No 1 hippie 234 699 195 195 0
PHC3_ENST00000494943 PHC3 Q8NDX5 Polyhomeotic-like protein 3 chr3 Not Cancer Driver No 1 hippie 102 795 85 85 0
PHIP PHIP Q8WWQ0 PH-interacting protein chr6 Not Cancer Driver No 1 hippie 239 835 110 110 0
PICK1 PICK1 Q9NRD5 PRKCA-binding protein chr22 Not Cancer Driver No 1 hippie 50 49 3 3 0
PIK3CB_ENST00000477593 PIK3CB P42338 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform chr3 Census, Compendium Yes 1 hippie 150 42 4 4 0
PIK3R1 PIK3R1 P27986 Phosphatidylinositol 3-kinase regulatory subunit alpha chr5 Census, Compendium Yes 1 hippie 154 268 61 61 2
PLEKHA4 PLEKHA4 Q9H4M7 Pleckstrin homology domain-containing family A member 4 chr19 Not Cancer Driver No 1 hippie 136 687 128 128 0
POU5F1 POU5F1 Q01860 POU domain, class 5, transcription factor 1 chr6 Census Yes 1 hippie 36 186 12 12 0
PPIB PPIB P23284 Peptidyl-prolyl cis-trans isomerase B chr15 Not Cancer Driver No 1 hippie 28 16 1 1 1
PPP1CB_ENST00000358506 PPP1CB P62140 Serine/threonine-protein phosphatase PP1-beta catalytic subunit chr2 Not Cancer Driver No 1 hippie 47 25 5 5 5
PPP1R12B_ENST00000608999 PPP1R12B O60237 Protein phosphatase 1 regulatory subunit 12B chr1 Not Cancer Driver No 1 hippie 143 801 119 119 0
PRC1 PRC1 O43663 Protein regulator of cytokinesis 1 chr15 Not Cancer Driver No 1 hippie 63 235 26 26 0
PRKCZ PRKCZ Q05513 Protein kinase C zeta type chr1 Not Cancer Driver No 1 hippie 70 116 11 11 0
PRKDC PRKDC P78527 DNA-dependent protein kinase catalytic subunit chr8 Not Cancer Driver No 1 hippie, biogrid 538 421 61 61 2
PTCD3 PTCD3 Q96EY7 Pentatricopeptide repeat domain-containing protein 3, mitochondrial chr2 Not Cancer Driver No 1 hippie 69 77 4 4 0
PTPN4 PTPN4 P29074 Tyrosine-protein phosphatase non-receptor type 4 chr2 Not Cancer Driver No 1 hippie 132 263 32 32 0
RAB5A RAB5A P20339 Ras-related protein Rab-5A chr3 Not Cancer Driver No 1 intact, hippie 32 65 15 15 0
RAD21 RAD21 O60216 Double-strand-break repair protein rad21 homolog chr8 Census, Compendium Yes 1 hippie 115 421 74 74 3
RAN_ENST00000392369 RAN P62826 GTP-binding nuclear protein Ran chr12 Not Cancer Driver No 1 hippie, biogrid 20 14 1 1 0
RBM4_ENST00000310092 RBM4 Q9BWF3 RNA-binding protein 4 chr11 Not Cancer Driver No 1 hippie, biogrid 40 129 12 12 0
RNF8 RNF8 O76064 E3 ubiquitin-protein ligase RNF8 chr6 Not Cancer Driver No 1 intact, hippie 56 226 29 29 0
RPGRIP1L_ENST00000379925 RPGRIP1L Q68CZ1 Protein fantom chr16 Not Cancer Driver No 1 hippie 177 586 94 94 8
RPL15_ENST00000413699 RPL15 P61313 60S ribosomal protein L15 chr3 Not Cancer Driver No 1 hippie 18 84 9 9 0
RPL18A RPL18A Q02543 60S ribosomal protein L18a chr19 Not Cancer Driver No 1 hippie, biogrid 28 25 4 4 0
RPL37A RPL37A P61513 60S ribosomal protein L37a chr2 Not Cancer Driver No 1 hippie, biogrid 4 0 0 0 0
RPL6 RPL6 Q02878 60S ribosomal protein L6 chr12 Not Cancer Driver No 1 hippie, biogrid 41 159 24 24 0
RPS19_ENST00000600467 RPS19 P39019 40S ribosomal protein S19 chr19 Not Cancer Driver No 1 hippie 15 61 3 3 23
RPS21 RPS21 P63220 40S ribosomal protein S21 chr20 Not Cancer Driver No 1 hippie 8 0 0 0 0
RRP12 RRP12 Q5JTH9 RRP12-like protein chr10 Not Cancer Driver No 1 hippie, biogrid 155 336 56 56 0
RRP7A RRP7A Q9Y3A4 Ribosomal RNA-processing protein 7 homolog A chr22 Not Cancer Driver No 1 hippie, biogrid 25 97 14 14 1
RRS1 RRS1 Q15050 Ribosome biogenesis regulatory protein homolog chr8 Not Cancer Driver No 1 hippie, biogrid 23 315 18 18 0
RYBP RYBP Q8N488 RING1 and YY1-binding protein chr3 Not Cancer Driver No 1 hippie 37 214 37 37 0
S100A9 S100A9 P06702 Protein S100-A9 chr1 Not Cancer Driver No 1 hippie, biogrid 18 76 7 7 0
SAMD4A SAMD4A Q9UPU9 Protein Smaug homolog 1 chr14 Not Cancer Driver No 1 hippie 83 473 55 55 0
SAP18_ENST00000607003 SAP18 O00422 Histone deacetylase complex subunit SAP18 chr13 Not Cancer Driver No 1 hippie, biogrid 18 99 14 14 0
SART1 SART1 O43290 U4/U6.U5 tri-snRNP-associated protein 1 chr11 Not Cancer Driver No 1 hippie, biogrid 71 685 63 63 0
SART3 SART3 Q15020 Squamous cell carcinoma antigen recognized by T-cells 3 chr12 Not Cancer Driver No 1 hippie, biogrid 101 404 45 45 0
SCOC SCOC Q9UIL1 Short coiled-coil protein chr4 Not Cancer Driver No 1 hippie 13 82 8 8 0
SDHA SDHA P31040 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial chr5 Census Yes 1 intact, hippie, biogrid 115 71 13 13 7
SEC23B SEC23B Q15437 Protein transport protein Sec23B chr20 Not Cancer Driver No 1 hippie 105 82 4 4 7
SEC62 SEC62 Q99442 Translocation protein SEC62 chr3 Not Cancer Driver No 1 hippie 41 211 23 23 0
SF1_ENST00000377390 SF1 Q15637 Splicing factor 1 chr11 Not Cancer Driver No 1 hippie 110 627 106 106 0
SF3B6 SF3B6 Q9Y3B4 Splicing factor 3B subunit 6 chr2 Not Cancer Driver No 1 hippie, biogrid 9 10 0 0 0
SFPQ SFPQ P23246 Splicing factor, proline- and glutamine-rich chr1 Census Yes 2 hippie, biogrid 59 595 48 48 0
SGF29 SGF29 Q96ES7 SAGA-associated factor 29 chr16 Not Cancer Driver No 1 hippie 31 131 17 17 0
SHC1_ENST00000368445 SHC1 P29353 SHC-transforming protein 1 chr1 Not Cancer Driver No 1 hippie 84 397 58 58 0
SIRT7 SIRT7 Q9NRC8 NAD-dependent protein deacetylase sirtuin-7 chr17 Not Cancer Driver No 1 hippie 48 163 15 15 0
SLFN11_ENST00000308377 SLFN11 Q7Z7L1 Schlafen family member 11 chr17 Not Cancer Driver No 1 hippie 177 34 8 8 0
SLMAP SLMAP Q14BN4 Sarcolemmal membrane-associated protein chr3 Not Cancer Driver No 1 hippie 77 464 38 38 0
SMAD2_ENST00000402690 SMAD2 Q15796 Mothers against decapentaplegic homolog 2 chr18 Census, Compendium Yes 1 intact, hippie 79 137 12 12 0
SMC3 SMC3 Q9UQE7 Structural maintenance of chromosomes protein 3 chr10 Not Cancer Driver No 1 hippie 149 605 70 70 0
SMC4_ENST00000344722 SMC4 Q9NTJ3 Structural maintenance of chromosomes protein 4 chr3 Not Cancer Driver No 1 hippie 175 539 55 55 0
SNRNP200 SNRNP200 O75643 U5 small nuclear ribonucleoprotein 200 kDa helicase chr2 Not Cancer Driver No 1 hippie 237 270 37 37 11
SNRPA1 SNRPA1 P09661 U2 small nuclear ribonucleoprotein A' chr15 Not Cancer Driver No 1 hippie, biogrid 33 93 14 14 0
SNRPD1 SNRPD1 P62314 Small nuclear ribonucleoprotein Sm D1 chr18 Not Cancer Driver No 1 hippie, biogrid 10 80 4 4 0
SNU13_ENST00000355257 SNU13 P55769 NHP2-like protein 1 chr22 Not Cancer Driver No 1 hippie 17 2 0 0 0
SOD1 SOD1 P00441 Superoxide dismutase [Cu-Zn] chr21 Not Cancer Driver No 1 hippie, biogrid 16 93 9 9 79
SPECC1L SPECC1L Q69YQ0 Cytospin-A chr22 Not Cancer Driver No 1 hippie 113 928 93 93 3
SPP1 SPP1 P10451 Osteopontin chr4 Not Cancer Driver No 1 hippie 56 296 54 54 0
SRP72_ENST00000642900 SRP72 O76094 Signal recognition particle subunit SRP72 chr4 Not Cancer Driver No 1 hippie 79 237 22 22 1
SRRT SRRT Q9BXP5 Serrate RNA effector molecule homolog chr7 Not Cancer Driver No 1 hippie 146 595 108 108 0
SRSF11 SRSF11 Q05519 Serine/arginine-rich splicing factor 11 chr1 Not Cancer Driver No 1 hippie, biogrid 63 362 55 55 0
SRSF5_ENST00000557154 SRSF5 Q13243 Serine/arginine-rich splicing factor 5 chr14 Not Cancer Driver No 1 hippie, biogrid 50 189 40 40 0
STAU1 STAU1 O95793 Double-stranded RNA-binding protein Staufen homolog 1 chr20 Not Cancer Driver No 1 hippie 77 456 63 63 0
STIP1_ENST00000305218 STIP1 P31948 Stress-induced-phosphoprotein 1 chr11 Not Cancer Driver No 1 hippie, biogrid 74 270 39 39 0
STYX STYX Q8WUJ0 Serine/threonine/tyrosine-interacting protein chr14 Not Cancer Driver No 1 intact 20 30 2 2 0
SUMO1_ENST00000392245 SUMO1 P63165 Small ubiquitin-related modifier 1 chr2 Not Cancer Driver No 1 hippie 10 76 7 7 0
SUMO2 SUMO2 P61956 Small ubiquitin-related modifier 2 chr17 Not Cancer Driver No 1 hippie 9 69 6 6 0
SYNCRIP SYNCRIP O60506 Heterogeneous nuclear ribonucleoprotein Q chr6 Not Cancer Driver No 1 hippie 93 285 39 39 0
SYTL2_ENST00000528231 SYTL2 Q9HCH5 Synaptotagmin-like protein 2 chr11 Not Cancer Driver No 1 hippie 137 635 104 104 0
TALDO1 TALDO1 P37837 Transaldolase chr11 Not Cancer Driver No 1 hippie 51 31 4 4 0
TCHP_ENST00000405876 TCHP Q9BT92 Trichoplein keratin filament-binding protein chr12 Not Cancer Driver No 1 hippie 60 356 50 50 0
TEN1 TEN1 Q86WV5 CST complex subunit TEN1 chr17 Not Cancer Driver No 1 hippie, biogrid 6 8 4 4 0
TGOLN2_ENST00000377386 TGOLN2 O43493 Trans-Golgi network integral membrane protein 2 chr2 Not Cancer Driver No 1 intact, hippie 51 399 46 46 0
THOC6 THOC6 Q86W42 THO complex subunit 6 homolog chr16 Not Cancer Driver No 1 hippie, biogrid 49 16 4 4 1
TMEM173 STING1 Q86WV6 Stimulator of interferon genes protein chr5 Not Cancer Driver No 1 intact 46 66 13 13 3
TNIP2 TNIP2 Q8NFZ5 TNFAIP3-interacting protein 2 chr4 Not Cancer Driver No 1 hippie 43 316 36 36 0
TNPO1 TNPO1 Q92973 Transportin-1 chr5 Not Cancer Driver No 1 hippie 99 68 7 7 0
TOP1 TOP1 P11387 DNA topoisomerase 1 chr20 Census, Compendium Yes 1 hippie, biogrid 93 391 53 53 0
TPT1_ENST00000530705 TPT1 P13693 Translationally-controlled tumor protein chr13 Not Cancer Driver No 1 hippie 17 43 6 6 0
TRAF6_ENST00000348124 TRAF6 Q9Y4K3 TNF receptor-associated factor 6 chr11 Not Cancer Driver No 1 intact, hippie 67 62 7 7 0
TULP4 TULP4 Q9NRJ4 Tubby-related protein 4 chr6 Not Cancer Driver No 1 hippie 215 879 115 115 0
TXNIP TXNIP Q9H3M7 Thioredoxin-interacting protein chr1 Not Cancer Driver No 1 hippie 61 77 14 14 0
U2AF2 U2AF2 P26368 Splicing factor U2AF 65 kDa subunit chr19 Compendium Yes 1 hippie, biogrid 78 191 28 28 0
UBE2A UBE2A P49459 Ubiquitin-conjugating enzyme E2 A chrX Compendium Yes 1 hippie 35 67 13 13 2
URI1 URI1 O94763 Unconventional prefoldin RPB5 interactor 1 chr19 Not Cancer Driver No 1 hippie 88 388 64 64 0
USO1_ENST00000514213 USO1 O60763 General vesicular transport factor p115 chr4 Not Cancer Driver No 1 hippie 78 368 28 28 0
USP7 USP7 Q93009 Ubiquitin carboxyl-terminal hydrolase 7 chr16 Not Cancer Driver No 1 intact 170 215 45 45 0
VCAM1 VCAM1 P19320 Vascular cell adhesion protein 1 chr1 Not Cancer Driver No 1 intact, hippie 188 110 28 28 0
VIRMA VIRMA Q69YN4 Protein virilizer homolog chr8 Not Cancer Driver No 1 hippie 211 631 93 93 0
VPS35 VPS35 Q96QK1 Vacuolar protein sorting-associated protein 35 chr16 Not Cancer Driver No 1 hippie 68 99 9 9 1
WDR5 WDR5 P61964 WD repeat-containing protein 5 chr9 Not Cancer Driver No 1 hippie, biogrid 30 35 3 3 0
XAB2 XAB2 Q9HCS7 Pre-mRNA-splicing factor SYF1 chr19 Not Cancer Driver No 1 hippie 128 127 17 17 0
XRCC6 XRCC6 P12956 X-ray repair cross-complementing protein 6 chr22 Not Cancer Driver No 1 hippie 66 140 12 12 0
YWHAQ YWHAQ P27348 14-3-3 protein theta chr2 Not Cancer Driver No 1 hippie 29 41 6 6 0
ZC3HC1 ZC3HC1 Q86WB0 Zinc finger C3HC-type protein 1 chr7 Not Cancer Driver No 2 hippie, biogrid 70 250 34 34 0
ZCCHC2 ZCCHC2 Q9C0B9 Zinc finger CCHC domain-containing protein 2 chr18 Not Cancer Driver No 1 hippie 111 870 86 86 0
ZDHHC5 ZDHHC5 Q9C0B5 Palmitoyltransferase ZDHHC5 chr11 Not Cancer Driver No 1 hippie 89 462 63 63 0
ZNF165 ZNF165 P49910 Zinc finger protein 165 chr6 Compendium Yes 1 hippie 69 206 33 33 0
ZNF236_ENST00000253159 ZNF236 Q9UL36 Zinc finger protein 236 chr18 Not Cancer Driver No 1 hippie 270 977 152 152 0
ZNF532_ENST00000591808 ZNF532 Q9HCE3 Zinc finger protein 532 chr18 Not Cancer Driver No 1 hippie 168 733 91 91 0
ZNF721_ENST00000338977 ZNF721 Q8TF20 Zinc finger protein 721 chr4 Compendium Yes 1 intact, hippie 202 145 34 34 0