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TARS2 ,TARS2 ,Q9BW92
  • Uniprot Accession= Q9BW92
  • Ensembl Transcript= ENST00000369064.7
  • Uniprot Name= TARS2
  • Name= Threonine--tRNA ligase, mitochondrial
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 0
  • Number of Interaction partner in biogrid: 66
  • Number of Interaction partner in hippie: 125
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
AARS2 AARS2 Q5JTZ9 Alanine--tRNA ligase, mitochondrial chr6 Not Cancer Driver No 1 hippie, biogrid 123 203 25 25 5
ACSM5 ACSM5 Q6NUN0 Acyl-coenzyme A synthetase ACSM5, mitochondrial chr16 Not Cancer Driver No 1 hippie, biogrid 152 84 27 27 0
ADAM7 ADAM7 Q9H2U9 Disintegrin and metalloproteinase domain-containing protein 7 chr8 Not Cancer Driver No 1 hippie, biogrid 241 55 22 22 0
AHSA1 AHSA1 O95433 Activator of 90 kDa heat shock protein ATPase homolog 1 chr14 Not Cancer Driver No 1 hippie 46 146 17 17 0
AIFM1 AIFM1 O95831 Apoptosis-inducing factor 1, mitochondrial chrX Not Cancer Driver No 1 hippie, biogrid 88 166 22 22 11
AK4 AK4 P27144 Adenylate kinase 4, mitochondrial chr1 Not Cancer Driver No 1 hippie, biogrid 26 24 3 3 0
AKAP1_ENST00000539273 AKAP1 Q92667 A-kinase anchor protein 1, mitochondrial chr17 Not Cancer Driver No 1 hippie, biogrid 107 537 67 67 0
AMACR_ENST00000335606 AMACR Q9UHK6 Alpha-methylacyl-CoA racemase chr5 Not Cancer Driver No 1 hippie, biogrid 56 38 8 8 3
AMBRA1_ENST00000458649 AMBRA1 Q9C0C7 Activating molecule in BECN1-regulated autophagy protein 1 chr11 Not Cancer Driver No 1 hippie 173 788 103 103 0
ANAPC2 ANAPC2 Q9UJX6 Anaphase-promoting complex subunit 2 chr9 Not Cancer Driver No 1 hippie, biogrid 104 146 26 26 0
APEX1_ENST00000555414 APEX1 P27695 DNA-(apurinic or apyrimidinic site) endonuclease chr14 Not Cancer Driver No 1 hippie 34 103 14 14 0
ARL6IP1 ARL6IP1 Q15041 ADP-ribosylation factor-like protein 6-interacting protein 1 chr16 Not Cancer Driver No 1 hippie 35 9 1 1 0
ASB6 ASB6 Q9NWX5 Ankyrin repeat and SOCS box protein 6 chr9 Not Cancer Driver No 1 hippie 35 31 3 3 0
AUH AUH Q13825 Methylglutaconyl-CoA hydratase, mitochondrial chr9 Not Cancer Driver No 1 hippie, biogrid 34 29 0 0 1
BIRC3_ENST00000532808 BIRC3 Q13489 Baculoviral IAP repeat-containing protein 3 chr11 Census, Compendium Yes 1 hippie 77 98 16 16 0
C20orf96 C20orf96 Q9NUD7 Uncharacterized protein C20orf96 chr20 Not Cancer Driver No 1 hippie, biogrid 39 148 17 17 0
CBR4 CBR4 Q8N4T8 3-oxoacyl-[acyl-carrier-protein] reductase chr4 Not Cancer Driver No 1 hippie, biogrid 15 4 0 0 0
CDC34 CDC34 P49427 Ubiquitin-conjugating enzyme E2 R1 chr19 Not Cancer Driver No 1 hippie 26 95 11 11 0
CDC37 CDC37 Q16543 Hsp90 co-chaperone Cdc37 chr19 Not Cancer Driver No 1 hippie 52 214 31 31 0
CFTR CFTR P13569 Cystic fibrosis transmembrane conductance regulator chr7 Not Cancer Driver No 1 hippie 287 145 18 18 151
CHORDC1 CHORDC1 Q9UHD1 Cysteine and histidine-rich domain-containing protein 1 chr11 Not Cancer Driver No 1 hippie 47 119 17 17 0
CLPP CLPP Q16740 ATP-dependent Clp protease proteolytic subunit, mitochondrial chr19 Not Cancer Driver No 1 hippie 22 83 9 9 3
COQ10A COQ10A Q96MF6 Coenzyme Q-binding protein COQ10 homolog A, mitochondrial chr12 Not Cancer Driver No 1 hippie 27 28 0 0 0
COQ9 COQ9 O75208 Ubiquinone biosynthesis protein COQ9, mitochondrial chr16 Not Cancer Driver No 1 hippie, biogrid 43 111 13 13 0
COX4I1 COX4I1 P13073 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial chr16 Not Cancer Driver No 1 hippie, biogrid 17 5 1 1 1
COX6B1_ENST00000592141 COX6B1 P14854 Cytochrome c oxidase subunit 6B1 chr19 Not Cancer Driver No 1 hippie 15 23 6 6 2
CS CS O75390 Citrate synthase, mitochondrial chr12 Not Cancer Driver No 2 hippie, biogrid 50 13 2 2 0
CUL3 CUL3 Q13618 Cullin-3 chr2 Census, Compendium Yes 1 hippie 123 167 23 23 3
DDIT4L DDIT4L Q96D03 DNA damage-inducible transcript 4-like protein chr4 Not Cancer Driver No 1 hippie 48 5 3 3 0
DDRGK1 DDRGK1 Q96HY6 DDRGK domain-containing protein 1 chr20 Not Cancer Driver No 1 hippie 34 181 23 23 0
DHRS2_ENST00000250383 DHRS2 Q13268 Dehydrogenase/reductase SDR family member 2, mitochondrial chr14 Not Cancer Driver No 1 hippie, biogrid 47 0 0 0 0
DNAJA2 DNAJA2 O60884 DnaJ homolog subfamily A member 2 chr16 Not Cancer Driver No 1 hippie, biogrid 50 174 27 27 0
DNAJC7 DNAJC7 Q99615 DnaJ homolog subfamily C member 7 chr17 Not Cancer Driver No 1 hippie, biogrid 41 102 9 9 0
EGFR EGFR P00533 Epidermal growth factor receptor chr7 Census, Compendium Yes 1 hippie 444 223 35 35 1
EGLN3 EGLN3 Q9H6Z9 Prolyl hydroxylase EGLN3 chr14 Not Cancer Driver No 1 hippie 33 13 0 0 0
EIF4A2 EIF4A2 Q14240 Eukaryotic initiation factor 4A-II chr3 Census Yes 1 hippie 77 27 14 14 0
ESR2 ESR2 Q92731 Estrogen receptor beta chr14 Not Cancer Driver No 1 hippie 90 92 11 11 1
EXD2 EXD2 Q9NVH0 Exonuclease 3'-5' domain-containing protein 2 chr14 Not Cancer Driver No 1 hippie, biogrid 58 176 15 15 0
F12 F12 P00748 Coagulation factor XII chr5 Not Cancer Driver No 1 hippie, biogrid 53 104 9 9 13
FAHD1_ENST00000427358 FAHD1 Q6P587 Acylpyruvase FAHD1, mitochondrial chr16 Not Cancer Driver No 1 hippie, biogrid 15 12 0 0 0
FASTKD3 FASTKD3 Q14CZ7 FAST kinase domain-containing protein 3, mitochondrial chr5 Not Cancer Driver No 1 hippie 106 6 1 1 0
FKBP7 FKBP7 Q9Y680 Peptidyl-prolyl cis-trans isomerase FKBP7 chr2 Not Cancer Driver No 1 hippie 28 52 9 9 0
FKBPL FKBPL Q9UIM3 FK506-binding protein-like chr6 Not Cancer Driver No 1 hippie 48 202 28 28 0
GCAT_ENST00000248924 GCAT O75600 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial chr22 Not Cancer Driver No 1 hippie, biogrid 59 2 0 0 0
GPR182 GPR182 O15218 G-protein coupled receptor 182 chr12 Not Cancer Driver No 1 hippie, biogrid 49 33 4 4 0
GPR45 GPR45 Q9Y5Y3 Probable G-protein coupled receptor 45 chr2 Not Cancer Driver No 1 hippie, biogrid 97 0 0 0 0
GPR55 GPR55 Q9Y2T6 G-protein coupled receptor 55 chr2 Not Cancer Driver No 1 hippie, biogrid 64 0 0 0 0
HAX1 HAX1 O00165 HCLS1-associated protein X-1 chr1 Not Cancer Driver No 1 hippie, biogrid 44 219 32 32 2
HINT2 HINT2 Q9BX68 Adenosine 5'-monophosphoramidase HINT2 chr9 Not Cancer Driver No 1 hippie, biogrid 10 29 2 2 0
HLA-C HLA-C P10321 HLA class I histocompatibility antigen, C alpha chain chr6 Not Cancer Driver No 1 hippie, biogrid 104 175 58 58 0
HNRNPL HNRNPL P14866 Heterogeneous nuclear ribonucleoprotein L chr19 Not Cancer Driver No 1 hippie 89 283 29 29 0
HOMEZ HOMEZ Q8IX15 Homeobox and leucine zipper protein Homez chr14 Not Cancer Driver No 1 hippie 83 401 70 70 0
HSCB HSCB Q8IWL3 Iron-sulfur cluster co-chaperone protein HscB chr22 Not Cancer Driver No 1 hippie 36 25 6 6 0
HSPD1 HSPD1 P10809 60 kDa heat shock protein, mitochondrial chr2 Not Cancer Driver No 1 hippie 61 82 6 6 2
JUN JUN P05412 Transcription factor Jun chr1 Census Yes 1 hippie 35 281 25 25 0
KDF1 KDF1 Q8NAX2 Keratinocyte differentiation factor 1 chr1 Not Cancer Driver No 1 hippie 61 277 50 50 0
KLRB1 KLRB1 Q12918 Killer cell lectin-like receptor subfamily B member 1 chr12 Not Cancer Driver No 1 hippie, biogrid 24 26 6 6 0
LAMTOR1 LAMTOR1 Q6IAA8 Ragulator complex protein LAMTOR1 chr11 Not Cancer Driver No 1 hippie, biogrid 13 96 7 7 0
LCK LCK P06239 Tyrosine-protein kinase Lck chr1 Census Yes 1 hippie, biogrid 86 94 13 13 1
LDHAL6B LDHAL6B Q9BYZ2 L-lactate dehydrogenase A-like 6B chr15 Not Cancer Driver No 1 hippie, biogrid 54 17 2 2 0
LMBR1L LMBR1L Q6UX01 Protein LMBR1L chr12 Not Cancer Driver No 1 hippie 57 4 0 0 0
LRRC61_ENST00000323078 LRRC61 Q9BV99 Leucine-rich repeat-containing protein 61 chr7 Not Cancer Driver No 1 hippie, biogrid 37 44 4 4 0
LRRK2 LRRK2 Q5S007 Leucine-rich repeat serine/threonine-protein kinase 2 chr12 Not Cancer Driver No 1 hippie 519 90 17 17 23
LZTS2 LZTS2 Q9BRK4 Leucine zipper putative tumor suppressor 2 chr10 Not Cancer Driver No 1 hippie 78 508 66 66 0
MAIP1 MAIP1 Q8WWC4 m-AAA protease-interacting protein 1, mitochondrial chr2 Not Cancer Driver No 1 hippie 28 12 0 0 0
MAL2 MAL2 Q969L2 Protein MAL2 chr8 Not Cancer Driver No 1 hippie 20 4 0 0 0
MCUR1 MCUR1 Q96AQ8 Mitochondrial calcium uniporter regulator 1 chr6 Not Cancer Driver No 1 hippie, biogrid 30 65 0 0 0
METTL17_ENST00000339374 METTL17 Q9H7H0 Methyltransferase-like protein 17, mitochondrial chr14 Not Cancer Driver No 1 hippie, biogrid 62 95 16 16 0
MEX3B MEX3B Q6ZN04 RNA-binding protein MEX3B chr15 Not Cancer Driver No 1 hippie 85 437 64 64 0
MRPL58 MRPL58 Q14197 Peptidyl-tRNA hydrolase ICT1, mitochondrial chr17 Not Cancer Driver No 1 hippie 28 105 13 13 0
MRPS12_ENST00000402029 MRPS12 O15235 28S ribosomal protein S12, mitochondrial chr19 Not Cancer Driver No 1 hippie, biogrid 18 59 11 11 0
MRPS17 MRPS17 Q9Y2R5 28S ribosomal protein S17, mitochondrial chr7 Not Cancer Driver No 1 hippie, biogrid 14 9 3 3 0
MRPS2 MRPS2 Q9Y399 28S ribosomal protein S2, mitochondrial chr9 Not Cancer Driver No 1 hippie, biogrid 32 57 6 6 3
MRPS24 MRPS24 Q96EL2 28S ribosomal protein S24, mitochondrial chr7 Not Cancer Driver No 1 hippie, biogrid 20 1 0 0 0
MRPS30 MRPS30 Q9NP92 39S ribosomal protein S30, mitochondrial chr5 Not Cancer Driver No 1 hippie, biogrid 54 53 10 10 0
MRRF MRRF Q96E11 Ribosome-recycling factor, mitochondrial chr9 Not Cancer Driver No 1 hippie, biogrid 23 118 9 9 0
MTG2 MTG2 Q9H4K7 Mitochondrial ribosome-associated GTPase 2 chr20 Not Cancer Driver No 1 hippie, biogrid 57 47 9 9 0
MTIF2_ENST00000403721 MTIF2 P46199 Translation initiation factor IF-2, mitochondrial chr2 Not Cancer Driver No 1 hippie, biogrid 101 112 9 9 0
MTRF1L MTRF1L Q9UGC7 Peptide chain release factor 1-like, mitochondrial chr6 Not Cancer Driver No 1 hippie, biogrid 31 183 12 12 0
MYL10 MYL10 Q9BUA6 Myosin regulatory light chain 10 chr7 Not Cancer Driver No 1 hippie, biogrid 40 49 7 7 0
NAA38_ENST00000575771 NAA38 Q9BRA0 N-alpha-acetyltransferase 38, NatC auxiliary subunit chr17 Not Cancer Driver No 1 hippie, biogrid 11 79 4 4 0
NDUFS7 NDUFS7 O75251 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial chr19 Not Cancer Driver No 1 hippie, biogrid 36 30 3 3 1
NEDD8 NEDD8 Q15843 NEDD8 chr14 Not Cancer Driver No 1 hippie 10 36 5 5 0
NIPSNAP3A NIPSNAP3A Q9UFN0 Protein NipSnap homolog 3A chr9 Not Cancer Driver No 1 hippie, biogrid 26 15 4 4 0
NIPSNAP3B NIPSNAP3B Q9BS92 Protein NipSnap homolog 3B chr9 Not Cancer Driver No 1 hippie, biogrid 31 15 1 1 0
NTRK1 NTRK1 P04629 High affinity nerve growth factor receptor chr1 Census, Compendium Yes 1 hippie 168 57 8 8 25
OXCT2 OXCT2 Q9BYC2 Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial chr1 Not Cancer Driver No 2 hippie, biogrid 55 56 6 6 0
P2RY8 P2RY8 Q86VZ1 P2Y purinoceptor 8 chrX Census, Compendium Yes 1 hippie, biogrid 126 23 5 5 0
PDHA1_ENST00000422285 PDHA1 P08559 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial chrX Not Cancer Driver No 1 hippie, biogrid 70 43 6 6 20
PDK1_ENST00000282077 PDK1 Q15118 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial chr2 Not Cancer Driver No 1 hippie 52 50 10 10 0
PLEKHA4 PLEKHA4 Q9H4M7 Pleckstrin homology domain-containing family A member 4 chr19 Not Cancer Driver No 1 hippie 136 687 128 128 0
PLIN3 PLIN3 O60664 Perilipin-3 chr19 Not Cancer Driver No 1 hippie 44 256 34 34 0
PPP1R15A PPP1R15A O75807 Protein phosphatase 1 regulatory subunit 15A chr19 Not Cancer Driver No 1 hippie 83 628 72 72 0
PRPH PRPH P41219 Peripherin chr12 Not Cancer Driver No 1 hippie, biogrid 37 239 20 20 0
PTPN18 PTPN18 Q99952 Tyrosine-protein phosphatase non-receptor type 18 chr2 Not Cancer Driver No 1 hippie 51 138 8 8 0
QRSL1 QRSL1 Q9H0R6 Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial chr6 Not Cancer Driver No 1 hippie, biogrid 63 63 4 4 2
RECQL4 RECQL4 O94761 ATP-dependent DNA helicase Q4 chr8 Census, Compendium Yes 1 hippie 138 608 71 71 1
RHOG_ENST00000396978 RHOG P84095 Rho-related GTP-binding protein RhoG chr11 Not Cancer Driver No 1 hippie 26 22 5 5 0
RMND1 RMND1 Q9NWS8 Required for meiotic nuclear division protein 1 homolog chr6 Not Cancer Driver No 1 hippie, biogrid 46 83 11 11 1
SFT2D1 SFT2D1 Q8WV19 Vesicle transport protein SFT2A chr6 Not Cancer Driver No 1 hippie 14 0 0 0 0
SHC2 SHC2 P98077 SHC-transforming protein 2 chr19 Not Cancer Driver No 1 hippie, biogrid 66 362 44 44 0
SLC16A11 SLC16A11 Q8NCK7 Monocarboxylate transporter 11 chr17 Not Cancer Driver No 1 hippie 33 72 5 5 0
SLC17A9 SLC17A9 Q9BYT1 Solute carrier family 17 member 9 chr20 Not Cancer Driver No 1 hippie 67 17 0 0 2
SLC25A10_ENST00000350690 SLC25A10 Q9UBX3 Mitochondrial dicarboxylate carrier chr17 Not Cancer Driver No 1 hippie, biogrid 33 0 0 0 0
SNRNP70 SNRNP70 P08621 U1 small nuclear ribonucleoprotein 70 kDa chr19 Not Cancer Driver No 1 hippie 38 416 37 37 0
SPRTN SPRTN Q9H040 DNA-dependent metalloprotease SPRTN chr1 Not Cancer Driver No 1 hippie 73 252 38 38 1
SSBP1_ENST00000484178 SSBP1 Q04837 Single-stranded DNA-binding protein, mitochondrial chr7 Not Cancer Driver No 1 hippie, biogrid 27 0 0 0 6
STAU1 STAU1 O95793 Double-stranded RNA-binding protein Staufen homolog 1 chr20 Not Cancer Driver No 1 hippie 77 456 63 63 0
SUMO2 SUMO2 P61956 Small ubiquitin-related modifier 2 chr17 Not Cancer Driver No 1 hippie 9 69 6 6 0
SYPL1 SYPL1 Q16563 Synaptophysin-like protein 1 chr7 Not Cancer Driver No 1 hippie 31 17 3 3 0
TEFM TEFM Q96QE5 Transcription elongation factor, mitochondrial chr17 Not Cancer Driver No 1 hippie, biogrid 37 26 5 5 0
TNFRSF10D TNFRSF10D Q9UBN6 Tumor necrosis factor receptor superfamily member 10D chr8 Not Cancer Driver No 1 hippie 51 193 28 28 0
TNFSF14 TNFSF14 O43557 Tumor necrosis factor ligand superfamily member 14 chr19 Not Cancer Driver No 1 hippie, biogrid 58 18 1 1 0
TRAP1 TRAP1 Q12931 Heat shock protein 75 kDa, mitochondrial chr16 Not Cancer Driver No 1 hippie, biogrid 74 110 11 11 0
TRIM43 TRIM43 Q96BQ3 Tripartite motif-containing protein 43 chr2 Not Cancer Driver No 1 hippie, biogrid 48 28 7 7 0
TRIM56 TRIM56 Q9BRZ2 E3 ubiquitin-protein ligase TRIM56 chr7 Not Cancer Driver No 1 hippie 110 217 36 36 0
TRMU TRMU O75648 Mitochondrial tRNA-specific 2-thiouridylase 1 chr22 Not Cancer Driver No 1 hippie, biogrid 40 28 5 5 2
TUFM TUFM P49411 Elongation factor Tu, mitochondrial chr16 Not Cancer Driver No 1 hippie, biogrid 51 50 3 3 1
TULP3_ENST00000448120 TULP3 O75386 Tubby-related protein 3 chr12 Not Cancer Driver No 1 hippie 66 218 29 29 0
UBD UBD O15205 Ubiquitin D chr6 Not Cancer Driver No 1 hippie 31 8 1 1 0
UBR5 UBR5 O95071 E3 ubiquitin-protein ligase UBR5 chr8 Census, Compendium Yes 1 hippie 340 1296 162 162 0
UQCRFS1 UQCRFS1 P47985 Cytochrome b-c1 complex subunit Rieske, mitochondrial chr19 Not Cancer Driver No 1 hippie, biogrid 43 47 4 4 1
WDR83 WDR83 Q9BRX9 WD repeat domain-containing protein 83 chr19 Not Cancer Driver No 1 hippie, biogrid 28 35 3 3 0
YARS2 YARS2 Q9Y2Z4 Tyrosine--tRNA ligase, mitochondrial chr12 Not Cancer Driver No 1 hippie, biogrid 59 62 11 11 2
ZFP36 ZFP36 P26651 mRNA decay activator protein ZFP36 chr19 Not Cancer Driver No 1 hippie 43 262 34 34 0