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SRGAP2 ,SRGAP2 ,O75044
  • Uniprot Accession= O75044
  • Ensembl Transcript= ENST00000573034.7
  • Uniprot Name= SRGAP2
  • Name= SLIT-ROBO Rho GTPase-activating protein 2
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 11
  • Number of Interaction partner in biogrid: 20
  • Number of Interaction partner in hippie: 138
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ACTB_ENST00000646664 ACTB P60709 Actin, cytoplasmic 1 chr7 Not Cancer Driver No 1 hippie, biogrid 112 43 5 5 5
AFDN_ENST00000447894 AFDN P55196 Afadin chr6 Census Yes 1 hippie 248 1247 180 180 0
AGAP1 AGAP1 Q9UPQ3 Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 chr2 Not Cancer Driver No 1 hippie 163 403 81 81 0
ANKRD34A ANKRD34A Q69YU3 Ankyrin repeat domain-containing protein 34A chr1 Not Cancer Driver No 1 hippie 90 410 78 78 0
ATAD3A ATAD3A Q9NVI7 ATPase family AAA domain-containing protein 3A chr1 Not Cancer Driver No 1 hippie 66 269 24 24 2
AURKAIP1_ENST00000321751 AURKAIP1 Q9NWT8 Aurora kinase A-interacting protein chr1 Not Cancer Driver No 1 hippie 18 104 8 8 0
BMI1 BMI1 P35226 Polycomb complex protein BMI-1 chr10 Not Cancer Driver No 1 intact, hippie 50 150 30 30 0
BSPRY BSPRY Q5W0U4 B box and SPRY domain-containing protein chr9 Not Cancer Driver No 1 hippie, biogrid 41 89 5 5 0
C11orf52 C11orf52 Q96A22 Uncharacterized protein C11orf52 chr11 Not Cancer Driver No 1 hippie, biogrid 15 108 12 12 0
CAMSAP2 CAMSAP2 Q08AD1 Calmodulin-regulated spectrin-associated protein 2 chr1 Not Cancer Driver No 1 hippie 176 1025 127 127 0
CBY1_ENST00000216029 CBY1 Q9Y3M2 Protein chibby homolog 1 chr22 Not Cancer Driver No 1 hippie 13 98 11 11 0
CCDC96 CCDC96 Q2M329 Coiled-coil domain-containing protein 96 chr4 Not Cancer Driver No 1 hippie, biogrid 74 308 41 41 0
CDC25B CDC25B P30305 M-phase inducer phosphatase 2 chr20 Not Cancer Driver No 1 hippie 80 328 43 43 0
CDC25C CDC25C P30307 M-phase inducer phosphatase 3 chr5 Not Cancer Driver No 1 hippie 61 224 26 26 0
CDH1 CDH1 P12830 Cadherin-1 chr16 Census, Compendium Yes 1 hippie 150 400 82 82 5
CDK16_ENST00000357227 CDK16 Q00536 Cyclin-dependent kinase 16 chrX Not Cancer Driver No 1 hippie 55 139 30 30 0
CEP19 CEP19 Q96LK0 Centrosomal protein of 19 kDa chr3 Not Cancer Driver No 1 hippie 30 71 11 11 0
CGN CGN Q9P2M7 Cingulin chr1 Not Cancer Driver No 1 hippie 152 1179 149 149 0
CHEK1_ENST00000428830 CHEK1 O14757 Serine/threonine-protein kinase Chk1 chr11 Not Cancer Driver No 1 hippie 58 86 16 16 0
CTBP1 CTBP1 Q13363 C-terminal-binding protein 1 chr4 Not Cancer Driver No 1 hippie 42 123 9 9 1
DCLK1 DCLK1 O15075 Serine/threonine-protein kinase DCLK1 chr13 Not Cancer Driver No 1 hippie 209 252 77 77 0
DENND1A DENND1A Q8TEH3 DENN domain-containing protein 1A chr9 Not Cancer Driver No 1 hippie 117 589 76 76 0
DENND4A_ENST00000431932 DENND4A Q7Z401 C-myc promoter-binding protein chr15 Not Cancer Driver No 1 hippie 199 570 64 64 0
DENND4C_ENST00000602925 DENND4C Q5VZ89 DENN domain-containing protein 4C chr9 Not Cancer Driver No 1 hippie 190 710 69 69 0
DEPDC1B DEPDC1B Q8WUY9 DEP domain-containing protein 1B chr5 Not Cancer Driver No 1 hippie 76 52 6 6 0
DIAPH1 DIAPH1 O60610 Protein diaphanous homolog 1 chr5 Not Cancer Driver No 1 hippie 118 692 57 57 1
DISC1_ENST00000439617 DISC1 Q9NRI5 Disrupted in schizophrenia 1 protein chr1 Not Cancer Driver No 2 intact, hippie 132 514 82 82 0
DUSP16 DUSP16 Q9BY84 Dual specificity protein phosphatase 16 chr12 Compendium Yes 1 hippie, biogrid 70 273 34 34 0
EDC3 EDC3 Q96F86 Enhancer of mRNA-decapping protein 3 chr15 Not Cancer Driver No 1 hippie 43 185 22 22 1
EFTUD2 EFTUD2 Q15029 116 kDa U5 small nuclear ribonucleoprotein component chr17 Compendium Yes 1 hippie 132 179 30 30 3
EIF4E2 EIF4E2 O60573 Eukaryotic translation initiation factor 4E type 2 chr2 Not Cancer Driver No 1 hippie 27 80 5 5 0
ESR1_ENST00000206249 ESR1 P03372 Estrogen receptor chr6 Census, Compendium Yes 1 hippie 121 195 27 27 2
ESR2 ESR2 Q92731 Estrogen receptor beta chr14 Not Cancer Driver No 1 hippie 90 92 11 11 1
EXOC1 EXOC1 Q9NV70 Exocyst complex component 1 chr4 Not Cancer Driver No 1 hippie 128 154 22 22 0
EZR EZR P15311 Ezrin chr6 Census Yes 1 hippie 66 295 35 35 0
FAM110A_ENST00000246100 FAM110A Q9BQ89 Protein FAM110A chr20 Not Cancer Driver No 1 hippie 20 244 12 12 0
FAM110B FAM110B Q8TC76 Protein FAM110B chr8 Not Cancer Driver No 1 hippie 75 299 65 65 0
FAM53C_ENST00000434981 FAM53C Q9NYF3 Protein FAM53C chr5 Not Cancer Driver No 1 hippie 51 296 45 45 0
FASLG FASLG P48023 Tumor necrosis factor ligand superfamily member 6 chr1 Not Cancer Driver No 1 hippie 65 94 18 18 1
FMNL1 FMNL1 O95466 Formin-like protein 1 chr17 Not Cancer Driver No 1 hippie 115 524 32 32 0
FMR1 FMR1 Q06787 Synaptic functional regulator FMR1 chrX Not Cancer Driver No 1 intact, hippie 124 327 70 70 3
GAB2 GAB2 Q9UQC2 GRB2-associated-binding protein 2 chr11 Not Cancer Driver No 1 hippie 85 537 73 73 0
GIGYF1_ENST00000646601 GIGYF1 O75420 GRB10-interacting GYF protein 1 chr7 Not Cancer Driver No 1 hippie 138 857 115 115 0
GIGYF2_ENST00000409547 GIGYF2 Q6Y7W6 GRB10-interacting GYF protein 2 chr2 Not Cancer Driver No 1 hippie 176 1096 158 158 6
GPHN_ENST00000315266 GPHN Q9NQX3 Gephyrin chr14 Census Yes 1 hippie 126 305 41 41 2
GRB2_ENST00000392564 GRB2 P62993 Growth factor receptor-bound protein 2 chr17 Not Cancer Driver No 1 intact 28 10 1 1 0
HDAC4 HDAC4 P56524 Histone deacetylase 4 chr2 Not Cancer Driver No 1 hippie 182 749 132 132 0
HDAC7_ENST00000427332 HDAC7 Q8WUI4 Histone deacetylase 7 chr12 Not Cancer Driver No 1 hippie 91 570 50 50 0
HECTD1 HECTD1 Q9ULT8 E3 ubiquitin-protein ligase HECTD1 chr14 Not Cancer Driver No 1 hippie 274 991 108 108 0
HERC2 HERC2 O95714 E3 ubiquitin-protein ligase HERC2 chr15 Compendium Yes 1 hippie 718 971 150 150 1
HIST1H1C H1-2 P16403 Histone H1.2 chr6 Not Cancer Driver No 1 intact 79 211 78 78 0
HNRNPL HNRNPL P14866 Heterogeneous nuclear ribonucleoprotein L chr19 Not Cancer Driver No 1 hippie 89 283 29 29 0
HTT HTT P42858 Huntingtin chr4 Not Cancer Driver No 1 intact, hippie 336 666 69 69 2
INPP5E INPP5E Q9NRR6 Phosphatidylinositol polyphosphate 5-phosphatase type IV chr9 Not Cancer Driver No 1 hippie 43 272 16 16 15
ITSN2 ITSN2 Q9NZM3 Intersectin-2 chr2 Not Cancer Driver No 1 hippie 207 680 92 92 0
KCTD3 KCTD3 Q9Y597 BTB/POZ domain-containing protein KCTD3 chr1 Not Cancer Driver No 1 hippie 113 324 45 45 0
KDM6B_ENST00000448097 KDM6B O15054 Lysine-specific demethylase 6B chr17 Not Cancer Driver No 1 hippie 189 1278 142 142 2
KIF13B KIF13B Q9NQT8 Kinesin-like protein KIF13B chr8 Not Cancer Driver No 1 hippie 187 968 82 82 0
KIF1B_ENST00000377086 KIF1B O60333 Kinesin-like protein KIF1B chr1 Not Cancer Driver No 1 hippie 253 633 106 106 1
KIF1C KIF1C O43896 Kinesin-like protein KIF1C chr17 Not Cancer Driver No 1 hippie 131 695 94 94 1
KRAS KRAS P01116 GTPase KRas chr12 Census, Compendium Yes 1 hippie, biogrid 788 7 2 2 27
KSR1_ENST00000644974 KSR1 Q8IVT5 Kinase suppressor of Ras 1 chr17 Not Cancer Driver No 1 hippie 114 404 58 58 0
KXD1_ENST00000222307 KXD1 Q9BQD3 KxDL motif-containing protein 1 chr19 Not Cancer Driver No 1 hippie, biogrid 24 104 17 17 0
LARP1 LARP1 Q6PKG0-3 Isoform 2 of La-related protein 1 chr5 Not Cancer Driver No 1 hippie 136 726 100 100 0
LIMA1_ENST00000341247 LIMA1 Q9UHB6 LIM domain and actin-binding protein 1 chr12 Not Cancer Driver No 1 hippie 88 687 81 81 0
LPIN3_ENST00000373257 LPIN3 Q9BQK8 Phosphatidate phosphatase LPIN3 chr20 Not Cancer Driver No 1 hippie 91 472 50 50 0
LRFN1 LRFN1 Q9P244 Leucine-rich repeat and fibronectin type III domain-containing protein 1 chr19 Not Cancer Driver No 1 hippie 96 278 37 37 0
LUZP4 LUZP4 Q9P127 Leucine zipper protein 4 chrX Not Cancer Driver No 1 hippie 74 313 74 74 0
MAGI1 MAGI1 Q96QZ7 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 chr3 Not Cancer Driver No 1 hippie 260 1212 220 220 0
MAP3K21 MAP3K21 Q5TCX8 Mitogen-activated protein kinase kinase kinase 21 chr1 Not Cancer Driver No 1 hippie 191 658 112 112 0
MAPKAP1 MAPKAP1 Q9BPZ7 Target of rapamycin complex 2 subunit MAPKAP1 chr9 Not Cancer Driver No 1 hippie 70 173 25 25 0
MAST3 MAST3 O60307 Microtubule-associated serine/threonine-protein kinase 3 chr19 Not Cancer Driver No 1 hippie 169 783 100 100 0
MELK MELK Q14680 Maternal embryonic leucine zipper kinase chr9 Not Cancer Driver No 1 hippie 76 162 24 24 0
MYO1G MYO1G B0I1T2 Unconventional myosin-Ig chr7 Not Cancer Driver No 1 hippie 125 117 12 12 0
NAA40 NAA40 Q86UY6 N-alpha-acetyltransferase 40 chr11 Not Cancer Driver No 1 hippie 22 30 3 3 0
NADK_ENST00000341991 NADK O95544 NAD kinase chr1 Not Cancer Driver No 1 hippie 59 91 18 18 0
NF1 NF1 P21359 Neurofibromin chr17 Census, Compendium Yes 1 hippie 375 406 47 47 85
NTRK1 NTRK1 P04629 High affinity nerve growth factor receptor chr1 Census, Compendium Yes 1 hippie 168 57 8 8 25
NUPR1_ENST00000324873 NUPR1 O60356 Nuclear protein 1 chr16 Not Cancer Driver No 1 hippie 10 82 10 10 0
OSBPL6_ENST00000190611 OSBPL6 Q9BZF3 Oxysterol-binding protein-related protein 6 chr2 Not Cancer Driver No 1 hippie 167 365 72 72 0
PAK1_ENST00000356341 PAK1 Q13153 Serine/threonine-protein kinase PAK 1 chr11 Not Cancer Driver No 1 hippie 57 299 30 30 2
PCM1 PCM1 Q15154 Pericentriolar material 1 protein chr8 Census Yes 2 hippie, biogrid 152 1665 134 134 0
PFN1 PFN1 P07737 Profilin-1 chr17 Not Cancer Driver No 1 hippie, biogrid 16 7 1 1 3
PHLDB2 PHLDB2 Q86SQ0 Pleckstrin homology-like domain family B member 2 chr3 Not Cancer Driver No 1 hippie 235 1030 190 190 0
PLEKHA5_ENST00000299275 PLEKHA5 Q9HAU0 Pleckstrin homology domain-containing family A member 5 chr12 Not Cancer Driver No 1 hippie 144 869 114 114 0
PLEKHA7 PLEKHA7 Q6IQ23 Pleckstrin homology domain-containing family A member 7 chr11 Not Cancer Driver No 1 hippie 152 919 121 121 0
PPM1H PPM1H Q9ULR3 Protein phosphatase 1H chr12 Not Cancer Driver No 1 hippie 71 140 23 23 0
PPP2R1A PPP2R1A P30153 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform chr19 Census, Compendium Yes 1 hippie 179 0 0 0 4
PRMT5 PRMT5 O14744 Protein arginine N-methyltransferase 5 chr14 Not Cancer Driver No 1 hippie 83 72 6 6 0
PRPS2_ENST00000380668 PRPS2 P11908 Ribose-phosphate pyrophosphokinase 2 chrX Not Cancer Driver No 1 hippie, biogrid 56 4 1 1 0
PTPN13_ENST00000411767 PTPN13 Q12923 Tyrosine-protein phosphatase non-receptor type 13 chr4 Census, Compendium Yes 1 hippie 299 1231 149 149 0
PTPN14 PTPN14 Q15678 Tyrosine-protein phosphatase non-receptor type 14 chr1 Compendium Yes 1 hippie 173 582 99 99 0
RAB11FIP2_ENST00000355624 RAB11FIP2 Q7L804 Rab11 family-interacting protein 2 chr10 Not Cancer Driver No 1 hippie 66 356 43 43 0
RAB3IP RAB3IP Q96QF0 Rab-3A-interacting protein chr12 Not Cancer Driver No 1 hippie 85 227 33 33 0
RAC1_ENST00000348035 RAC1 P63000 Ras-related C3 botulinum toxin substrate 1 chr7 Census, Compendium Yes 1 hippie 66 2 1 1 6
RAC3 RAC3 P60763 Ras-related C3 botulinum toxin substrate 3 chr17 Not Cancer Driver No 1 hippie 24 0 0 0 4
RALGPS2 RALGPS2 Q86X27 Ras-specific guanine nucleotide-releasing factor RalGPS2 chr1 Not Cancer Driver No 1 hippie 83 183 23 23 0
RASAL2_ENST00000462775 RASAL2 Q9UJF2 Ras GTPase-activating protein nGAP chr1 Not Cancer Driver No 1 hippie 164 606 86 86 0
RHOF RHOF Q9HBH0 Rho-related GTP-binding protein RhoF chr12 Not Cancer Driver No 1 hippie 18 10 0 0 0
RHOQ RHOQ P17081 Rho-related GTP-binding protein RhoQ chr2 Not Cancer Driver No 1 hippie 25 0 0 0 0
RHOU RHOU Q7L0Q8 Rho-related GTP-binding protein RhoU chr1 Not Cancer Driver No 1 hippie 34 63 6 6 0
ROBO1 ROBO1 Q9Y6N7 Roundabout homolog 1 chr3 Not Cancer Driver No 1 hippie 353 1122 234 234 0
RPTOR RPTOR Q8N122 Regulatory-associated protein of mTOR chr17 Not Cancer Driver No 1 hippie 176 241 21 21 0
RTKN RTKN Q9BST9 Rhotekin chr2 Not Cancer Driver No 1 hippie 67 265 35 35 0
S100P S100P P25815 Protein S100-P chr4 Not Cancer Driver No 1 hippie, biogrid 7 3 1 1 0
SH3BP4_ENST00000392011 SH3BP4 Q9P0V3 SH3 domain-binding protein 4 chr2 Not Cancer Driver No 1 hippie 143 241 43 43 0
SH3GL2 SH3GL2 Q99962 Endophilin-A1 chr9 Not Cancer Driver No 1 intact 76 214 50 50 0
SH3PXD2A_ENST00000369774 SH3PXD2A Q5TCZ1 SH3 and PX domain-containing protein 2A chr10 Not Cancer Driver No 1 hippie 141 797 101 101 0
SH3RF3 SH3RF3 Q8TEJ3 E3 ubiquitin-protein ligase SH3RF3 chr2 Not Cancer Driver No 1 hippie 98 564 53 53 0
SIPA1L1 SIPA1L1 O43166 Signal-induced proliferation-associated 1-like protein 1 chr14 Not Cancer Driver No 1 hippie 321 1175 226 226 0
SLC25A12 SLC25A12 O75746 Calcium-binding mitochondrial carrier protein Aralar1 chr2 Not Cancer Driver No 1 hippie 110 21 7 7 2
SMAD4_ENST00000398417 SMAD4 Q13485 Mothers against decapentaplegic homolog 4 chr18 Census, Compendium Yes 1 hippie 198 195 17 17 8
SMARCA4 SMARCA4 P51532 Transcription activator BRG1 chr19 Census, Compendium Yes 1 intact 349 1072 195 195 5
SRGAP1 SRGAP1 Q7Z6B7 SLIT-ROBO Rho GTPase-activating protein 1 chr12 Not Cancer Driver No 1 hippie, biogrid 191 553 87 87 4
SRGAP2 SRGAP2 O75044 SLIT-ROBO Rho GTPase-activating protein 2 chr1 Not Cancer Driver No 2 intact, hippie 122 541 71 71 0
SRGAP3 SRGAP3 O43295 SLIT-ROBO Rho GTPase-activating protein 3 chr3 Census, Compendium Yes 1 hippie, biogrid 195 549 97 97 0
SRSF12 SRSF12 Q8WXF0 Serine/arginine-rich splicing factor 12 chr6 Not Cancer Driver No 1 hippie 36 205 31 31 0
STARD13 STARD13 Q9Y3M8 StAR-related lipid transfer protein 13 chr13 Not Cancer Driver No 1 hippie 177 494 78 78 0
SUV39H1_ENST00000376687 SUV39H1 O43463 Histone-lysine N-methyltransferase SUV39H1 chrX Not Cancer Driver No 1 intact 59 15 1 1 0
SYDE1 SYDE1 Q6ZW31 Rho GTPase-activating protein SYDE1 chr19 Not Cancer Driver No 1 hippie 62 412 27 27 0
TANC2 TANC2 Q9HCD6 Protein TANC2 chr17 Not Cancer Driver No 1 hippie 278 999 127 127 1
TBC1D25 TBC1D25 Q3MII6 TBC1 domain family member 25 chrX Not Cancer Driver No 1 hippie 114 256 37 37 0
TESK2 TESK2 Q96S53 Dual specificity testis-specific protein kinase 2 chr1 Not Cancer Driver No 1 hippie 77 242 43 43 0
TIAM1 TIAM1 Q13009 Rho guanine nucleotide exchange factor TIAM1 chr21 Not Cancer Driver No 1 hippie 370 810 194 194 0
TNIK TNIK Q9UKE5 TRAF2 and NCK-interacting protein kinase chr3 Not Cancer Driver No 2 intact 254 781 156 156 0
TRIML2 TRIML2 Q8N7C3 Probable E3 ubiquitin-protein ligase TRIML2 chr4 Not Cancer Driver No 2 hippie, biogrid 165 77 28 28 0
TULP3_ENST00000448120 TULP3 O75386 Tubby-related protein 3 chr12 Not Cancer Driver No 1 hippie 66 218 29 29 0
UBA52_ENST00000595683 UBA52 P62987 Ubiquitin-60S ribosomal protein L40 chr19 Not Cancer Driver No 1 hippie 19 45 8 8 0
UBD UBD O15205 Ubiquitin D chr6 Not Cancer Driver No 1 hippie 31 8 1 1 0
USP21_ENST00000289865 USP21 Q9UK80 Ubiquitin carboxyl-terminal hydrolase 21 chr1 Not Cancer Driver No 1 hippie 95 230 47 47 0
VIRMA VIRMA Q69YN4 Protein virilizer homolog chr8 Not Cancer Driver No 1 hippie 211 631 93 93 0
WAS WAS P42768 Wiskott-Aldrich syndrome protein chrX Census, Compendium Yes 1 hippie 75 400 55 55 30
WIPF1_ENST00000359761 WIPF1 O43516 WAS/WASL-interacting protein family member 1 chr2 Not Cancer Driver No 1 hippie 110 503 110 110 0
YLPM1 YLPM1 P49750 YLP motif-containing protein 1 chr14 Not Cancer Driver No 1 hippie 251 1985 226 226 0
YWHAB_ENST00000353703 YWHAB P31946 14-3-3 protein beta/alpha chr20 Not Cancer Driver No 2 hippie, biogrid 22 109 4 4 0
YWHAE YWHAE P62258 14-3-3 protein epsilon chr17 Census Yes 1 hippie 32 41 3 3 0
YWHAG YWHAG P61981 14-3-3 protein gamma chr7 Not Cancer Driver No 2 hippie, biogrid 26 77 9 9 2
YWHAH YWHAH Q04917 14-3-3 protein eta chr22 Not Cancer Driver No 2 hippie, biogrid 15 55 3 3 0
YWHAQ YWHAQ P27348 14-3-3 protein theta chr2 Not Cancer Driver No 2 hippie, biogrid 29 41 6 6 0
YWHAZ_ENST00000395956 YWHAZ P63104 14-3-3 protein zeta/delta chr8 Not Cancer Driver No 2 hippie, biogrid 30 81 10 10 0
ZBTB21 ZBTB21 Q9ULJ3 Zinc finger and BTB domain-containing protein 21 chr21 Not Cancer Driver No 1 hippie 136 645 75 75 0
ZDHHC5 ZDHHC5 Q9C0B5 Palmitoyltransferase ZDHHC5 chr11 Not Cancer Driver No 1 hippie 89 462 63 63 0
ZNF414_ENST00000255616 ZNF414 Q96IQ9 Zinc finger protein 414 chr19 Not Cancer Driver No 1 hippie, biogrid 24 240 19 19 0
ZNF638 ZNF638 Q14966 Zinc finger protein 638 chr2 Not Cancer Driver No 1 hippie 243 1667 209 209 0