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SPTA1_ENST00000368147 ,SPTA1 ,P02549
  • Uniprot Accession= P02549
  • Ensembl Transcript= ENST00000368147.8
  • Uniprot Name= SPTA1
  • Name= Spectrin alpha chain, erythrocytic 1
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 20
  • Number of Interaction partner in biogrid: 2
  • Number of Interaction partner in hippie: 86
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ABI1 ABI1 Q8IZP0 Abl interactor 1 chr10 Census, Compendium Yes 1 intact, hippie 55 360 39 39 0
ABL1_ENST00000318560 ABL1 P00519 Tyrosine-protein kinase ABL1 chr9 Census, Compendium Yes 1 hippie 139 604 73 73 2
ACTA1 ACTA1 P68133 Actin, alpha skeletal muscle chr1 Not Cancer Driver No 1 hippie 70 48 14 14 84
ADAM10 ADAM10 O14672 Disintegrin and metalloproteinase domain-containing protein 10 chr15 Not Cancer Driver No 1 intact, hippie 88 156 20 20 4
ADD1_ENST00000398129 ADD1 P35611 Alpha-adducin chr4 Not Cancer Driver No 1 hippie 106 439 64 64 0
AGR2 AGR2 O95994 Anterior gradient protein 2 homolog chr7 Not Cancer Driver No 1 hippie 23 20 2 2 0
ANK1_ENST00000347528 ANK1 P16157 Ankyrin-1 chr8 Census Yes 1 hippie 405 810 171 171 3
APP APP P05067 Amyloid-beta precursor protein chr21 Not Cancer Driver No 1 hippie 128 418 71 71 17
BCKDK BCKDK O14874 [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial chr16 Not Cancer Driver No 1 hippie 62 39 3 3 3
BRIP1 BRIP1 Q9BX63 Fanconi anemia group J protein chr17 Census Yes 1 hippie 174 397 59 59 6
BTK_ENST00000308731 BTK Q06187 Tyrosine-protein kinase BTK chrX Census, Compendium Yes 1 hippie 147 114 27 27 110
C21orf58 C21orf58 P58505 Uncharacterized protein C21orf58 chr21 Not Cancer Driver No 1 intact, hippie 31 305 29 29 0
CBL CBL P22681 E3 ubiquitin-protein ligase CBL chr11 Census, Compendium Yes 1 hippie 115 512 56 56 4
CCDC185 CCDC185 Q8N715 Coiled-coil domain-containing protein 185 chr1 Not Cancer Driver No 1 intact, hippie 99 590 94 94 0
CEP250 CEP250 Q9BV73 Centrosome-associated protein CEP250 chr20 Not Cancer Driver No 1 hippie, biogrid 250 1859 195 195 0
CUL4A CUL4A Q13619 Cullin-4A chr13 Not Cancer Driver No 1 hippie 64 102 2 2 0
DCAF15 DCAF15 Q66K64 DDB1- and CUL4-associated factor 15 chr19 Not Cancer Driver No 1 hippie 50 173 18 18 0
DGCR6L DGCR6L Q9BY27 Protein DGCR6L chr22 Not Cancer Driver No 1 hippie 16 76 8 8 0
EMD EMD P50402 Emerin chrX Not Cancer Driver No 1 hippie 42 160 28 28 4
ENAH ENAH Q8N8S7 Protein enabled homolog chr1 Not Cancer Driver No 1 intact, hippie 65 514 61 61 0
EPB41L3 EPB41L3 Q9Y2J2 Band 4.1-like protein 3 chr18 Not Cancer Driver No 1 hippie 298 695 207 207 0
ERCC1_ENST00000589165 ERCC1 P07992 DNA excision repair protein ERCC-1 chr19 Not Cancer Driver No 1 hippie 42 105 14 14 1
ERCC2 ERCC2 P18074 General transcription and DNA repair factor IIH helicase subunit XPD chr19 Census, Compendium Yes 1 hippie 150 5 0 0 35
ERCC3 ERCC3 P19447 General transcription and DNA repair factor IIH helicase subunit XPB chr2 Census, Compendium Yes 1 hippie 92 208 22 22 2
ERCC4 ERCC4 Q92889 DNA repair endonuclease XPF chr16 Census Yes 1 hippie 120 225 27 27 15
ERCC5 ERCC5 P28715 DNA excision repair protein ERCC-5 chr13 Census Yes 1 hippie 175 816 121 121 6
ERCC6 ERCC6 Q03468 DNA excision repair protein ERCC-6 chr10 Not Cancer Driver No 1 hippie 211 829 117 117 9
EVL_ENST00000402714 EVL Q9UI08 Ena/VASP-like protein chr14 Not Cancer Driver No 1 intact, hippie 42 335 37 37 0
EXOSC5 EXOSC5 Q9NQT4 Exosome complex component RRP46 chr19 Not Cancer Driver No 1 intact, hippie 43 31 3 3 0
EZR EZR P15311 Ezrin chr6 Census Yes 1 hippie 66 295 35 35 0
FANCA FANCA O15360 Fanconi anemia group A protein chr16 Census, Compendium Yes 1 hippie 160 154 15 15 27
FANCC FANCC Q00597 Fanconi anemia group C protein chr9 Census, Compendium Yes 1 hippie 66 13 1 1 3
FANCD2_ENST00000383807 FANCD2 Q9BXW9 Fanconi anemia group D2 protein chr3 Census, Compendium Yes 1 hippie 176 181 14 14 3
FANCF FANCF Q9NPI8 Fanconi anemia group F protein chr11 Census, Compendium Yes 1 hippie 32 51 4 4 0
FANCG FANCG O15287 Fanconi anemia group G protein chr9 Census Yes 1 hippie 64 48 3 3 1
FASLG FASLG P48023 Tumor necrosis factor ligand superfamily member 6 chr1 Not Cancer Driver No 1 hippie 65 94 18 18 1
GADD45GIP1 GADD45GIP1 Q8TAE8 Growth arrest and DNA damage-inducible proteins-interacting protein 1 chr19 Not Cancer Driver No 1 hippie 19 193 19 19 0
GAN GAN Q9H2C0 Gigaxonin chr16 Not Cancer Driver No 1 hippie 74 33 6 6 19
GJA1 GJA1 P17302 Gap junction alpha-1 protein chr6 Not Cancer Driver No 1 hippie 86 110 26 26 50
HIST3H3 H3-4 Q16695 Histone H3.1t chr1 Not Cancer Driver No 1 intact 37 51 10 10 0
HNRNPA2B1 HNRNPA2B1 P22626 Heterogeneous nuclear ribonucleoproteins A2/B1 chr7 Census, Compendium Yes 1 hippie 68 255 41 41 0
HRAS HRAS P01112 GTPase HRas chr11 Census, Compendium Yes 1 hippie 107 16 4 4 18
KRAS KRAS P01116 GTPase KRas chr12 Census, Compendium Yes 1 hippie 788 7 2 2 27
KRT75 KRT75 O95678 Keratin, type II cytoskeletal 75 chr12 Not Cancer Driver No 1 intact, hippie 126 142 35 35 1
LMNA LMNA P02545 Prelamin-A/C chr1 Census Yes 1 hippie 68 544 49 49 131
MRE11 MRE11 P49959 Double-strand break repair protein MRE11 chr11 Not Cancer Driver No 1 hippie 84 292 35 35 1
MYBL2 MYBL2 P10244 Myb-related protein B chr20 Not Cancer Driver No 1 hippie 111 506 85 85 0
NCOA3 NCOA3 Q9Y6Q9 Nuclear receptor coactivator 3 chr20 Not Cancer Driver No 1 hippie 176 1231 160 160 0
NRAS NRAS P01111 GTPase NRas chr1 Census, Compendium Yes 1 hippie 284 10 0 0 14
ODF3B ODF3B A8MYP8 Outer dense fiber protein 3B chr22 Not Cancer Driver No 1 intact, hippie 10 183 5 5 0
PARP1 PARP1 P09874 Poly [ADP-ribose] polymerase 1 chr1 Not Cancer Driver No 1 intact, hippie 119 320 34 34 0
PKP2 PKP2 Q99959 Plakophilin-2 chr12 Not Cancer Driver No 1 intact, hippie 176 434 98 98 8
PLEC PLEC Q15149 Plectin chr8 Not Cancer Driver No 1 hippie 677 2130 272 272 2
PML PML P29590 Protein PML chr15 Census, Compendium Yes 1 hippie 112 312 34 34 0
PTEN PTEN P60484 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN chr10 Census, Compendium Yes 1 hippie 505 76 4 4 41
PTPN22 PTPN22 Q9Y2R2 Tyrosine-protein phosphatase non-receptor type 22 chr1 Not Cancer Driver No 1 hippie 141 364 62 62 4
PTPRO PTPRO Q16827 Receptor-type tyrosine-protein phosphatase O chr12 Not Cancer Driver No 1 hippie 204 137 34 34 0
RAD23B RAD23B P54727 UV excision repair protein RAD23 homolog B chr9 Not Cancer Driver No 1 hippie 54 324 41 41 0
RAD50 RAD50 Q92878 DNA repair protein RAD50 chr5 Not Cancer Driver No 1 hippie 157 730 84 84 0
RAD51_ENST00000267868 RAD51 Q06609 DNA repair protein RAD51 homolog 1 chr15 Not Cancer Driver No 1 hippie 42 47 5 5 3
RPA1 RPA1 P27694 Replication protein A 70 kDa DNA-binding subunit chr17 Not Cancer Driver No 1 hippie 51 98 6 6 0
RPA2_ENST00000373912 RPA2 P15927 Replication protein A 32 kDa subunit chr1 Not Cancer Driver No 1 hippie 28 114 16 16 0
RPSA_ENST00000301821 RPSA P08865 40S ribosomal protein SA chr3 Not Cancer Driver No 1 hippie 22 95 6 6 5
SHC1_ENST00000368445 SHC1 P29353 SHC-transforming protein 1 chr1 Not Cancer Driver No 1 intact, hippie 84 397 58 58 0
SLC4A1 SLC4A1 P02730 Band 3 anion transport protein chr17 Not Cancer Driver No 1 intact, hippie 153 130 23 23 39
SLC9A2 SLC9A2 Q9UBY0 Sodium/hydrogen exchanger 2 chr2 Not Cancer Driver No 1 hippie 165 221 63 63 0
SMARCA2 SMARCA2 P51531 Probable global transcription activator SNF2L2 chr9 Not Cancer Driver No 1 hippie 273 1009 160 160 42
SMARCA4 SMARCA4 P51532 Transcription activator BRG1 chr19 Census, Compendium Yes 1 hippie 349 1072 195 195 5
SNIP1 SNIP1 Q8TAD8 Smad nuclear-interacting protein 1 chr1 Not Cancer Driver No 1 hippie 58 285 40 40 1
SPTA1_ENST00000368147 SPTA1 P02549 Spectrin alpha chain, erythrocytic 1 chr1 Not Cancer Driver No 1 hippie 1046 707 294 294 21
SPTBN1 SPTBN1 Q01082 Spectrin beta chain, non-erythrocytic 1 chr2 Not Cancer Driver No 1 intact, hippie 311 869 123 123 0
SPTBN2 SPTBN2 O15020 Spectrin beta chain, non-erythrocytic 2 chr11 Not Cancer Driver No 1 hippie 317 877 126 126 2
SPTBN4_ENST00000598249 SPTBN4 Q9H254 Spectrin beta chain, non-erythrocytic 4 chr19 Not Cancer Driver No 1 hippie 312 866 103 103 0
SPTB_ENST00000389721 SPTB P11277 Spectrin beta chain, erythrocytic chr14 Not Cancer Driver No 2 hippie, biogrid 328 562 70 70 7
TP53_ENST00000445888 TP53 P04637 Cellular tumor antigen p53 chr17 Census, Compendium Yes 1 hippie 2891 282 1466 1466 83
TSHZ2 TSHZ2 Q9NRE2 Teashirt homolog 2 chr20 Not Cancer Driver No 1 intact, hippie 323 784 241 241 0
TXN2_ENST00000403313 TXN2 Q99757 Thioredoxin, mitochondrial chr22 Not Cancer Driver No 1 intact, hippie 22 34 4 4 0
UBASH3B UBASH3B Q8TF42 Ubiquitin-associated and SH3 domain-containing protein B chr11 Not Cancer Driver No 1 intact, hippie 86 73 6 6 0
UBE2A UBE2A P49459 Ubiquitin-conjugating enzyme E2 A chrX Compendium Yes 1 hippie 35 67 13 13 2
USP11 USP11 P51784 Ubiquitin carboxyl-terminal hydrolase 11 chrX Not Cancer Driver No 1 hippie 140 210 28 28 0
VASP VASP P50552 Vasodilator-stimulated phosphoprotein chr19 Not Cancer Driver No 1 intact, hippie 39 335 34 34 0
XPA XPA P23025 DNA repair protein complementing XP-A cells chr9 Census Yes 1 hippie 27 121 13 13 5
XRCC2 XRCC2 O43543 DNA repair protein XRCC2 chr7 Not Cancer Driver No 1 hippie 36 9 1 1 2
XRCC5_ENST00000392132 XRCC5 P13010 X-ray repair cross-complementing protein 5 chr2 Not Cancer Driver No 1 hippie 87 118 11 11 0
XRCC6 XRCC6 P12956 X-ray repair cross-complementing protein 6 chr22 Not Cancer Driver No 1 hippie 66 140 12 12 0
YWHAQ YWHAQ P27348 14-3-3 protein theta chr2 Not Cancer Driver No 1 hippie 29 41 6 6 0
ZNF326 ZNF326 Q5BKZ1 DBIRD complex subunit ZNF326 chr1 Not Cancer Driver No 1 intact, hippie 64 490 53 53 0