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SPEN ,SPEN ,Q96T58
  • Uniprot Accession= Q96T58
  • Ensembl Transcript= ENST00000375759.7
  • Uniprot Name= SPEN
  • Name= Msx2-interacting protein
  • Chromosome= chr1
  • Driver status= Census, Compendium
  • Number of Interaction partner in intact: 0
  • Number of Interaction partner in biogrid: 36
  • Number of Interaction partner in hippie: 105
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ABT1 ABT1 Q9ULW3 Activator of basal transcription 1 chr6 Not Cancer Driver No 1 hippie, biogrid 56 157 30 30 0
ANKRD36B ANKRD36B Q8N2N9 Ankyrin repeat domain-containing protein 36B chr2 Not Cancer Driver No 1 hippie, biogrid 63 803 39 39 0
ASF1A ASF1A Q9Y294 Histone chaperone ASF1A chr6 Not Cancer Driver No 1 hippie, biogrid 18 69 2 2 0
ATXN1 ATXN1 P54253 Ataxin-1 chr6 Not Cancer Driver No 1 hippie 193 604 168 168 0
BAG2 BAG2 O95816 BAG family molecular chaperone regulator 2 chr6 Not Cancer Driver No 1 hippie, biogrid 17 112 9 9 0
BAG4 BAG4 O95429 BAG family molecular chaperone regulator 4 chr8 Not Cancer Driver No 1 hippie, biogrid 55 402 49 49 0
BCL6_ENST00000232014 BCL6 P41182 B-cell lymphoma 6 protein chr3 Census, Compendium Yes 1 hippie 134 328 67 67 0
BCLAF1 BCLAF1 Q9NYF8 Bcl-2-associated transcription factor 1 chr6 Census, Compendium Yes 1 hippie 421 899 408 408 0
BIRC3_ENST00000532808 BIRC3 Q13489 Baculoviral IAP repeat-containing protein 3 chr11 Census, Compendium Yes 1 hippie 77 98 16 16 0
BMI1 BMI1 P35226 Polycomb complex protein BMI-1 chr10 Not Cancer Driver No 1 hippie 50 150 30 30 0
BPGM_ENST00000344924 BPGM P07738 Bisphosphoglycerate mutase chr7 Not Cancer Driver No 1 hippie, biogrid 34 15 0 0 2
CAMKV CAMKV Q8NCB2 CaM kinase-like vesicle-associated protein chr3 Not Cancer Driver No 2 hippie, biogrid 87 226 30 30 0
CBX3_ENST00000396386 CBX3 Q13185 Chromobox protein homolog 3 chr7 Not Cancer Driver No 1 hippie, biogrid 23 119 18 18 0
CCNC CCNC P24863 Cyclin-C chr6 Census Yes 3 hippie, biogrid 32 33 3 3 0
CCT8L2 CCT8L2 Q96SF2 T-complex protein 1 subunit theta-like 2 chr22 Not Cancer Driver No 1 hippie, biogrid 216 104 46 46 0
CDC5L CDC5L Q99459 Cell division cycle 5-like protein chr6 Not Cancer Driver No 1 hippie 100 618 77 77 0
CHD4 CHD4 Q14839 Chromodomain-helicase-DNA-binding protein 4 chr12 Census, Compendium Yes 1 hippie 419 974 177 177 6
CLK1_ENST00000321356 CLK1 P49759 Dual specificity protein kinase CLK1 chr2 Not Cancer Driver No 1 hippie 64 131 21 21 0
CRK CRK P46108 Adapter molecule crk chr17 Not Cancer Driver No 1 hippie 30 197 23 23 0
CTBP1 CTBP1 Q13363 C-terminal-binding protein 1 chr4 Not Cancer Driver No 1 hippie 42 123 9 9 1
CUL7_ENST00000265348 CUL7 Q14999 Cullin-7 chr6 Not Cancer Driver No 1 hippie 188 372 41 41 3
DAXX_ENST00000266000 DAXX Q9UER7 Death domain-associated protein 6 chr6 Census, Compendium Yes 2 hippie, biogrid 106 549 81 81 0
DHX8 DHX8 Q14562 ATP-dependent RNA helicase DHX8 chr17 Not Cancer Driver No 1 hippie, biogrid 138 490 72 72 0
DLX5 DLX5 P56178 Homeobox protein DLX-5 chr7 Not Cancer Driver No 1 hippie 71 223 57 57 1
DPPA4 DPPA4 Q7L190 Developmental pluripotency-associated protein 4 chr3 Not Cancer Driver No 1 hippie 94 180 46 46 0
DYNLT1 DYNLT1 P63172 Dynein light chain Tctex-type 1 chr6 Not Cancer Driver No 1 hippie 7 1 0 0 0
EED_ENST00000263360 EED O75530 Polycomb protein EED chr11 Census Yes 1 hippie 64 79 11 11 6
EGFR EGFR P00533 Epidermal growth factor receptor chr7 Census, Compendium Yes 1 hippie 444 223 35 35 1
ESR1_ENST00000206249 ESR1 P03372 Estrogen receptor chr6 Census, Compendium Yes 1 hippie 121 195 27 27 2
EZH2_ENST00000460911 EZH2 Q15910 Histone-lysine N-methyltransferase EZH2 chr7 Census, Compendium Yes 1 hippie 120 284 44 44 11
FERMT3 FERMT3 Q86UX7 Fermitin family homolog 3 chr11 Not Cancer Driver No 1 hippie 99 108 14 14 0
FHL2_ENST00000408995 FHL2 Q14192 Four and a half LIM domains protein 2 chr2 Not Cancer Driver No 1 hippie, biogrid 30 0 0 0 0
GRB2_ENST00000392564 GRB2 P62993 Growth factor receptor-bound protein 2 chr17 Not Cancer Driver No 1 hippie 28 10 1 1 0
HDAC1 HDAC1 Q13547 Histone deacetylase 1 chr1 Not Cancer Driver No 1 hippie 47 135 10 10 0
HDAC2 HDAC2 Q92769 Histone deacetylase 2 chr6 Not Cancer Driver No 1 hippie 46 145 14 14 0
HIF1AN HIF1AN Q9NWT6 Hypoxia-inducible factor 1-alpha inhibitor chr10 Not Cancer Driver No 1 hippie 37 77 9 9 0
HMGA1 HMGA1 P17096 High mobility group protein HMG-I/HMG-Y chr6 Census Yes 1 hippie 6 107 6 6 0
HNF4A HNF4A P41235 Hepatocyte nuclear factor 4-alpha chr20 Not Cancer Driver No 1 hippie 135 127 48 48 5
HSPA1A HSPA1A P0DMV8 Heat shock 70 kDa protein 1A chr6 Not Cancer Driver No 1 hippie, biogrid 24 200 13 13 0
HSPA2_ENST00000247207 HSPA2 P54652 Heat shock-related 70 kDa protein 2 chr14 Not Cancer Driver No 1 hippie, biogrid 93 286 38 38 0
HSPA8_ENST00000532636 HSPA8 P11142 Heat shock cognate 71 kDa protein chr11 Not Cancer Driver No 1 hippie, biogrid 149 251 52 52 0
IRF2BP2 IRF2BP2 Q7Z5L9 Interferon regulatory factor 2-binding protein 2 chr1 Not Cancer Driver No 1 hippie 42 451 26 26 1
KCNE3 KCNE3 Q9Y6H6 Potassium voltage-gated channel subfamily E member 3 chr11 Not Cancer Driver No 1 hippie, biogrid 28 24 2 2 0
KLF8 KLF8 O95600 Krueppel-like factor 8 chrX Not Cancer Driver No 1 hippie 71 270 53 53 0
MBD3 MBD3 O95983 Methyl-CpG-binding domain protein 3 chr19 Not Cancer Driver No 1 hippie 50 246 46 46 0
MED23 MED23 Q9ULK4 Mediator of RNA polymerase II transcription subunit 23 chr6 Not Cancer Driver No 1 hippie 158 28 2 2 1
MKI67 MKI67 P46013 Proliferation marker protein Ki-67 chr10 Not Cancer Driver No 1 hippie, biogrid 540 3169 529 529 0
MSX2 MSX2 P35548 Homeobox protein MSX-2 chr5 Not Cancer Driver No 1 hippie 27 168 14 14 4
MTA2 MTA2 O94776 Metastasis-associated protein MTA2 chr11 Not Cancer Driver No 1 hippie 78 283 32 32 0
MYC_ENST00000377970 MYC P01106 Myc proto-oncogene protein chr8 Census, Compendium Yes 1 hippie 80 299 46 46 0
NCBP2_ENST00000427641 NCBP2 P52298-3 Isoform 3 of Nuclear cap-binding protein subunit 2 chr3 Not Cancer Driver No 1 hippie 21 61 9 9 0
NCK1_ENST00000288986 NCK1 P16333 Cytoplasmic protein NCK1 chr3 Not Cancer Driver No 1 hippie 48 111 17 17 0
NCOR1 NCOR1 O75376 Nuclear receptor corepressor 1 chr17 Census, Compendium Yes 1 hippie 352 2347 340 340 0
NCOR2 NCOR2 Q9Y618 Nuclear receptor corepressor 2 chr12 Census, Compendium Yes 1 hippie 373 2355 356 356 0
NFIX_ENST00000592199 NFIX Q14938 Nuclear factor 1 X-type chr19 Not Cancer Driver No 1 hippie 60 305 40 40 6
NFKBIL1 NFKBIL1 Q9UBC1 NF-kappa-B inhibitor-like protein 1 chr6 Not Cancer Driver No 1 hippie, biogrid 37 316 33 33 0
NOTCH2 NOTCH2 Q04721 Neurogenic locus notch homolog protein 2 chr1 Census, Compendium Yes 1 hippie, biogrid 282 630 77 77 1
NR3C1_ENST00000343796 NR3C1 P04150 Glucocorticoid receptor chr5 Not Cancer Driver No 1 hippie 92 362 37 37 12
NUP50 NUP50 Q9UKX7 Nuclear pore complex protein Nup50 chr22 Not Cancer Driver No 1 hippie, biogrid 58 333 40 40 0
NUP54 NUP54 Q7Z3B4 Nucleoporin p54 chr4 Not Cancer Driver No 1 hippie, biogrid 42 233 25 25 0
OBSL1 OBSL1 O75147 Obscurin-like protein 1 chr2 Not Cancer Driver No 1 hippie 233 553 60 60 0
PCBP3 PCBP3 P57721 Poly(rC)-binding protein 3 chr21 Not Cancer Driver No 1 hippie, biogrid 65 230 48 48 0
PIK3R1 PIK3R1 P27986 Phosphatidylinositol 3-kinase regulatory subunit alpha chr5 Census, Compendium Yes 1 hippie 154 268 61 61 2
PIP4K2A PIP4K2A P48426 Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha chr10 Not Cancer Driver No 2 hippie, biogrid 56 123 15 15 0
PIR_ENST00000380420 PIR O00625 Pirin chrX Not Cancer Driver No 1 hippie, biogrid 29 185 16 16 0
PLCD3 PLCD3 Q8N3E9 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 chr17 Not Cancer Driver No 1 hippie, biogrid 61 229 22 22 0
PLCG1_ENST00000373271 PLCG1 P19174 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 chr20 Census, Compendium Yes 1 hippie 158 186 21 21 0
PPARD_ENST00000360694 PPARD Q03181 Peroxisome proliferator-activated receptor delta chr6 Not Cancer Driver No 1 hippie 72 69 7 7 0
PRC1 PRC1 O43663 Protein regulator of cytokinesis 1 chr15 Not Cancer Driver No 1 hippie 63 235 26 26 0
PRDX3 PRDX3 P30048 Thioredoxin-dependent peroxide reductase, mitochondrial chr10 Not Cancer Driver No 1 hippie, biogrid 23 23 3 3 0
PYHIN1 PYHIN1 Q6K0P9 Pyrin and HIN domain-containing protein 1 chr1 Not Cancer Driver No 1 hippie 174 291 99 99 0
RAD18 RAD18 Q9NS91 E3 ubiquitin-protein ligase RAD18 chr3 Not Cancer Driver No 1 hippie 59 328 43 43 0
RARA RARA P10276 Retinoic acid receptor alpha chr17 Census, Compendium Yes 1 hippie 70 167 14 14 0
RBBP4 RBBP4 Q09028 Histone-binding protein RBBP4 chr1 Not Cancer Driver No 1 hippie 53 169 23 23 0
RBBP8_ENST00000327155 RBBP8 Q99708 DNA endonuclease RBBP8 chr18 Not Cancer Driver No 1 hippie 99 750 76 76 1
RBPJ_ENST00000361572 RBPJ Q06330 Recombining binding protein suppressor of hairless chr4 Not Cancer Driver No 4 hippie, biogrid 49 151 19 19 2
RHOBTB1 RHOBTB1 O94844 Rho-related BTB domain-containing protein 1 chr10 Not Cancer Driver No 1 hippie 95 121 19 19 0
RIDA RIDA P52758 2-iminobutanoate/2-iminopropanoate deaminase chr8 Not Cancer Driver No 1 hippie 20 3 0 0 0
RPL10A RPL10A P62906 60S ribosomal protein L10a chr6 Not Cancer Driver No 1 hippie 22 16 0 0 0
RRP1B RRP1B Q14684 Ribosomal RNA processing protein 1 homolog B chr21 Not Cancer Driver No 1 hippie 74 513 48 48 0
RUNX1T1_ENST00000614812 RUNX1T1 Q06455 Protein CBFA2T1 chr8 Census, Compendium Yes 1 hippie 292 469 229 229 0
RUNX1_ENST00000344691 RUNX1 Q01196 Runt-related transcription factor 1 chr21 Census, Compendium Yes 1 hippie 81 360 58 58 2
SCYL2_ENST00000360820 SCYL2 Q6P3W7 SCY1-like protein 2 chr12 Not Cancer Driver No 1 hippie, biogrid 103 328 29 29 0
SERTAD1 SERTAD1 Q9UHV2 SERTA domain-containing protein 1 chr19 Not Cancer Driver No 1 hippie 24 164 18 18 0
SIRT7 SIRT7 Q9NRC8 NAD-dependent protein deacetylase sirtuin-7 chr17 Not Cancer Driver No 1 hippie 48 163 15 15 0
SOX2 SOX2 P48431 Transcription factor SOX-2 chr3 Census Yes 1 hippie 39 312 39 39 0
SOX9 SOX9 P48436 Transcription factor SOX-9 chr17 Compendium Yes 1 hippie 86 495 82 82 18
SRPK2_ENST00000489828 SRPK2 P78362 SRSF protein kinase 2 chr7 Not Cancer Driver No 1 hippie 78 343 46 46 0
SRSF6 SRSF6 Q13247 Serine/arginine-rich splicing factor 6 chr20 Not Cancer Driver No 1 hippie, biogrid 69 259 49 49 0
SULF2_ENST00000484875 SULF2 Q8IWU5 Extracellular sulfatase Sulf-2 chr20 Not Cancer Driver No 1 hippie, biogrid 145 142 18 18 0
SUMO1_ENST00000392245 SUMO1 P63165 Small ubiquitin-related modifier 1 chr2 Not Cancer Driver No 1 hippie 10 76 7 7 0
SUPT5H SUPT5H O00267 Transcription elongation factor SPT5 chr19 Not Cancer Driver No 1 hippie 165 572 87 87 0
TBXT TBXT O15178 T-box transcription factor T chr6 Not Cancer Driver No 1 hippie 110 253 69 69 1
TCTE1 TCTE1 Q5JU00 Dynein regulatory complex subunit 5 chr6 Not Cancer Driver No 1 hippie 101 125 20 20 0
TERF2IP TERF2IP Q9NYB0 Telomeric repeat-binding factor 2-interacting protein 1 chr16 Not Cancer Driver No 1 hippie, biogrid 28 310 16 16 0
TRIM37 TRIM37 O94972 E3 ubiquitin-protein ligase TRIM37 chr17 Not Cancer Driver No 1 hippie 119 492 60 60 3
TRIML2 TRIML2 Q8N7C3 Probable E3 ubiquitin-protein ligase TRIML2 chr4 Not Cancer Driver No 2 hippie, biogrid 165 77 28 28 0
TTN_ENST00000615779 TTN Q8WZ42 Titin chr2 Not Cancer Driver No 1 hippie, biogrid 7917 12926 2861 2861 10
UBE2E2_ENST00000425792 UBE2E2 Q96LR5 Ubiquitin-conjugating enzyme E2 E2 chr3 Not Cancer Driver No 1 hippie 28 90 15 15 0
UBE2L6 UBE2L6 O14933 Ubiquitin/ISG15-conjugating enzyme E2 L6 chr11 Not Cancer Driver No 1 hippie 19 7 1 1 0
USP37_ENST00000454775 USP37 Q86T82 Ubiquitin carboxyl-terminal hydrolase 37 chr2 Not Cancer Driver No 1 hippie 112 530 62 62 0
VIRMA VIRMA Q69YN4 Protein virilizer homolog chr8 Not Cancer Driver No 1 hippie 211 631 93 93 0
WRAP73 WRAP73 Q9P2S5 WD repeat-containing protein WRAP73 chr1 Not Cancer Driver No 3 hippie, biogrid 50 5 0 0 0
XRCC6 XRCC6 P12956 X-ray repair cross-complementing protein 6 chr22 Not Cancer Driver No 1 hippie 66 140 12 12 0
ZC3H18_ENST00000301011 ZC3H18 Q86VM9 Zinc finger CCCH domain-containing protein 18 chr16 Not Cancer Driver No 1 hippie, biogrid 139 929 134 134 0