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S1PR1 ,S1PR1 ,P21453
  • Uniprot Accession= P21453
  • Ensembl Transcript= ENST00000305352.6
  • Uniprot Name= S1PR1
  • Name= Sphingosine 1-phosphate receptor 1
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 21
  • Number of Interaction partner in biogrid: 91
  • Number of Interaction partner in hippie: 108
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ACAD9 ACAD9 Q9H845 Complex I assembly factor ACAD9, mitochondrial chr3 Not Cancer Driver No 1 hippie, biogrid 69 28 5 5 12
ACP2 ACP2 P11117 Lysosomal acid phosphatase chr11 Not Cancer Driver No 2 intact, hippie, biogrid 41 77 11 11 0
AKT1_ENST00000349310 AKT1 P31749 RAC-alpha serine/threonine-protein kinase chr14 Census, Compendium Yes 1 hippie 108 158 24 24 4
APP APP P05067 Amyloid-beta precursor protein chr21 Not Cancer Driver No 1 hippie 128 418 71 71 17
ARL10 ARL10 Q8N8L6 ADP-ribosylation factor-like protein 10 chr5 Not Cancer Driver No 1 intact, hippie, biogrid 19 19 0 0 0
ATP12A_ENST00000381946 ATP12A P54707 Potassium-transporting ATPase alpha chain 2 chr13 Not Cancer Driver No 2 intact, hippie, biogrid 203 117 24 24 0
ATP1A3_ENST00000302102 ATP1A3 P13637 Sodium/potassium-transporting ATPase subunit alpha-3 chr19 Not Cancer Driver No 2 hippie, biogrid 200 115 29 29 31
ATP2A3_ENST00000397041 ATP2A3 Q93084 Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 chr17 Not Cancer Driver No 1 hippie, biogrid 130 147 16 16 0
ATP2B2 ATP2B2 Q01814 Plasma membrane calcium-transporting ATPase 2 chr3 Not Cancer Driver No 1 hippie, biogrid 248 360 82 82 0
ATP2B3_ENST00000349466 ATP2B3 Q16720 Plasma membrane calcium-transporting ATPase 3 chrX Census Yes 1 intact, hippie, biogrid 245 328 74 74 2
ATP2C1_ENST00000508532 ATP2C1 P98194 Calcium-transporting ATPase type 2C member 1 chr3 Not Cancer Driver No 1 hippie, biogrid 125 44 5 5 20
B4GAT1 B4GAT1 O43505 Beta-1,4-glucuronyltransferase 1 chr11 Not Cancer Driver No 1 hippie, biogrid 52 4 0 0 2
BTAF1 BTAF1 O14981 TATA-binding protein-associated factor 172 chr10 Not Cancer Driver No 1 hippie, biogrid 215 360 52 52 0
C1orf112_ENST00000359326 C1orf112 Q9NSG2 Uncharacterized protein C1orf112 chr1 Not Cancer Driver No 1 hippie, biogrid 100 26 2 2 0
CAV1 CAV1 Q03135 Caveolin-1 chr7 Not Cancer Driver No 1 hippie 30 2 0 0 0
CD47 CD47 Q08722 Leukocyte surface antigen CD47 chr3 Not Cancer Driver No 2 intact, hippie, biogrid 37 0 0 0 0
CD69 CD69 Q07108 Early activation antigen CD69 chr12 Not Cancer Driver No 1 intact, hippie 32 18 3 3 0
CERS6_ENST00000305747 CERS6 Q6ZMG9 Ceramide synthase 6 chr2 Not Cancer Driver No 1 hippie, biogrid 54 32 10 10 0
CHCHD6 CHCHD6 Q9BRQ6 MICOS complex subunit MIC25 chr3 Not Cancer Driver No 1 hippie, biogrid 27 194 24 24 0
CKAP4 CKAP4 Q07065 Cytoskeleton-associated protein 4 chr12 Not Cancer Driver No 1 hippie, biogrid 73 409 55 55 0
CKAP5 CKAP5 Q14008 Cytoskeleton-associated protein 5 chr11 Not Cancer Driver No 1 hippie, biogrid 198 634 64 64 0
CLEC2D_ENST00000290855 CLEC2D Q9UHP7 C-type lectin domain family 2 member D chr12 Not Cancer Driver No 2 intact, hippie, biogrid 28 14 1 1 0
CMSS1 CMSS1 Q9BQ75 Protein CMSS1 chr3 Not Cancer Driver No 1 intact, hippie 52 98 16 16 0
CMTM6 CMTM6 Q9NX76 CKLF-like MARVEL transmembrane domain-containing protein 6 chr3 Not Cancer Driver No 1 hippie, biogrid 10 30 0 0 0
CNNM4 CNNM4 Q6P4Q7 Metal transporter CNNM4 chr2 Not Cancer Driver No 1 hippie, biogrid 104 116 22 22 4
COLEC12 COLEC12 Q5KU26 Collectin-12 chr18 Not Cancer Driver No 1 hippie, biogrid 147 450 90 90 0
COX16 COX16 Q9P0S2 Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial chr14 Not Cancer Driver No 1 hippie, biogrid 13 39 6 6 0
CYBA CYBA P13498 Cytochrome b-245 light chain chr16 Not Cancer Driver No 1 hippie, biogrid 26 66 2 2 12
DYM DYM Q7RTS9 Dymeclin chr18 Not Cancer Driver No 1 hippie, biogrid 78 21 0 0 3
ECSIT ECSIT Q9BQ95 Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial chr19 Not Cancer Driver No 1 hippie, biogrid 58 146 29 29 0
ERGIC2 ERGIC2 Q96RQ1 Endoplasmic reticulum-Golgi intermediate compartment protein 2 chr12 Not Cancer Driver No 1 hippie, biogrid 37 25 2 2 0
EXTL3 EXTL3 O43909 Exostosin-like 3 chr8 Not Cancer Driver No 1 hippie, biogrid 138 110 24 24 5
FAM241B FAM241B Q96D05 Protein FAM241B chr10 Not Cancer Driver No 1 hippie 25 53 9 9 0
FANCD2_ENST00000383807 FANCD2 Q9BXW9 Fanconi anemia group D2 protein chr3 Census, Compendium Yes 1 hippie, biogrid 176 181 14 14 3
FRMD5 FRMD5 Q7Z6J6 FERM domain-containing protein 5 chr15 Not Cancer Driver No 1 hippie, biogrid 69 134 20 20 0
GBF1 GBF1 Q92538 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 chr10 Not Cancer Driver No 1 hippie, biogrid 216 669 76 76 0
GNA13 GNA13 Q14344 Guanine nucleotide-binding protein subunit alpha-13 chr17 Compendium Yes 1 intact, hippie, biogrid 52 32 4 4 0
GNAI1 GNAI1 P63096 Guanine nucleotide-binding protein G(i) subunit alpha-1 chr7 Not Cancer Driver No 1 hippie 52 11 3 3 0
GNAI3 GNAI3 P08754 Guanine nucleotide-binding protein G(i) subunit alpha-3 chr1 Not Cancer Driver No 1 hippie 42 11 0 0 1
GNAQ GNAQ P50148 Guanine nucleotide-binding protein G(q) subunit alpha chr9 Census, Compendium Yes 1 intact, hippie, biogrid 57 14 1 1 1
GNG5_ENST00000370645 GNG5 P63218 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 chr1 Not Cancer Driver No 1 intact, hippie, biogrid 5 9 1 1 0
GOLPH3L GOLPH3L Q9H4A5 Golgi phosphoprotein 3-like chr1 Not Cancer Driver No 1 intact, hippie, biogrid 24 81 12 12 0
GPAT4 GPAT4 Q86UL3 Glycerol-3-phosphate acyltransferase 4 chr8 Not Cancer Driver No 1 hippie 64 3 0 0 0
GPR180 GPR180 Q86V85 Integral membrane protein GPR180 chr13 Not Cancer Driver No 1 hippie, biogrid 38 11 1 1 0
GPRIN1 GPRIN1 Q7Z2K8 G protein-regulated inducer of neurite outgrowth 1 chr5 Not Cancer Driver No 2 intact, hippie, biogrid 116 999 115 115 0
HK3 HK3 P52790 Hexokinase-3 chr5 Not Cancer Driver No 1 intact, hippie, biogrid 164 71 17 17 0
HRAS HRAS P01112 GTPase HRas chr11 Census, Compendium Yes 1 intact, hippie, biogrid 107 16 4 4 18
HTR1A HTR1A P08908 5-hydroxytryptamine receptor 1A chr5 Not Cancer Driver No 1 hippie 170 100 49 49 0
HTR1D HTR1D P28221 5-hydroxytryptamine receptor 1D chr1 Not Cancer Driver No 1 hippie 54 24 1 1 0
IPO7 IPO7 O95373 Importin-7 chr11 Not Cancer Driver No 1 hippie, biogrid 138 202 30 30 0
IPO8 IPO8 O15397 Importin-8 chr12 Not Cancer Driver No 1 hippie, biogrid 130 111 13 13 0
IPO9 IPO9 Q96P70 Importin-9 chr1 Not Cancer Driver No 1 hippie, biogrid 145 102 22 22 0
ITPRIPL1_ENST00000439118 ITPRIPL1 Q6GPH6 Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1 chr2 Not Cancer Driver No 1 hippie, biogrid 65 39 3 3 0
KIAA2013_ENST00000616327 KIAA2013 Q8IYS2 Uncharacterized protein KIAA2013 chr1 Not Cancer Driver No 1 hippie, biogrid 35 78 5 5 0
LMBR1 LMBR1 Q8WVP7 Limb region 1 protein homolog chr7 Not Cancer Driver No 1 intact, hippie, biogrid 56 19 1 1 0
MKRN2 MKRN2 Q9H000 E3 ubiquitin-protein ligase makorin-2 chr3 Not Cancer Driver No 1 hippie 45 145 16 16 0
MON2 MON2 Q7Z3U7 Protein MON2 homolog chr12 Not Cancer Driver No 1 hippie, biogrid 201 151 16 16 0
MRS2_ENST00000378386 MRS2 Q9HD23 Magnesium transporter MRS2 homolog, mitochondrial chr6 Not Cancer Driver No 1 hippie, biogrid 47 0 0 0 0
NDUFAF1 NDUFAF1 Q9Y375 Complex I intermediate-associated protein 30, mitochondrial chr15 Not Cancer Driver No 1 hippie, biogrid 44 63 8 8 4
PDGFRB PDGFRB P09619 Platelet-derived growth factor receptor beta chr5 Census, Compendium Yes 1 hippie 164 231 44 44 7
PKD2 PKD2 Q13563 Polycystin-2 chr4 Not Cancer Driver No 1 hippie, biogrid 113 375 35 35 10
POMGNT1_ENST00000371984 POMGNT1 Q8WZA1 Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 chr1 Not Cancer Driver No 1 hippie, biogrid 75 90 13 13 20
POTEF POTEF A5A3E0 POTE ankyrin domain family member F chr2 Not Cancer Driver No 1 intact, hippie, biogrid 269 453 93 93 0
PPM1B PPM1B O75688 Protein phosphatase 1B chr2 Not Cancer Driver No 1 hippie, biogrid 65 243 31 31 0
PPP6R1_ENST00000587283 PPP6R1 Q9UPN7 Serine/threonine-protein phosphatase 6 regulatory subunit 1 chr19 Not Cancer Driver No 1 hippie, biogrid 82 471 47 47 0
PTDSS2 PTDSS2 Q9BVG9 Phosphatidylserine synthase 2 chr11 Not Cancer Driver No 1 hippie, biogrid 41 92 4 4 0
RAP2A RAP2A P10114 Ras-related protein Rap-2a chr13 Not Cancer Driver No 1 hippie, biogrid 15 9 0 0 0
RER1 RER1 O15258 Protein RER1 chr1 Not Cancer Driver No 1 hippie, biogrid 18 15 3 3 0
RHOT2 RHOT2 Q8IXI1 Mitochondrial Rho GTPase 2 chr16 Not Cancer Driver No 1 hippie, biogrid 52 79 5 5 0
RMDN3 RMDN3 Q96TC7 Regulator of microtubule dynamics protein 3 chr15 Not Cancer Driver No 1 hippie, biogrid 45 196 17 17 0
S1PR2 S1PR2 O95136 Sphingosine 1-phosphate receptor 2 chr19 Not Cancer Driver No 1 intact, hippie 38 16 3 3 2
SAAL1 SAAL1 Q96ER3 Protein SAAL1 chr11 Not Cancer Driver No 1 hippie, biogrid 46 75 11 11 0
SACM1L SACM1L Q9NTJ5 Phosphatidylinositol-3-phosphatase SAC1 chr3 Not Cancer Driver No 1 hippie, biogrid 41 0 0 0 0
SLC38A10 SLC38A10 Q9HBR0 Putative sodium-coupled neutral amino acid transporter 10 chr17 Not Cancer Driver No 1 hippie, biogrid 128 719 82 82 0
SLC39A10_ENST00000359634 SLC39A10 Q9ULF5 Zinc transporter ZIP10 chr2 Not Cancer Driver No 1 hippie, biogrid 111 417 63 63 0
SLC39A4 SLC39A4 Q6P5W5 Zinc transporter ZIP4 chr8 Not Cancer Driver No 1 hippie, biogrid 77 116 11 11 9
SORT1 SORT1 Q99523 Sortilin chr1 Not Cancer Driver No 1 hippie, biogrid 69 110 2 2 0
SP1 SP1 P08047 Transcription factor Sp1 chr12 Not Cancer Driver No 1 intact, hippie 96 599 71 71 0
SRC_ENST00000358208 SRC P12931 Proto-oncogene tyrosine-protein kinase Src chr20 Census Yes 1 intact, hippie, biogrid 53 130 11 11 1
STX17_ENST00000534052 STX17 P56962 Syntaxin-17 chr9 Not Cancer Driver No 1 hippie, biogrid 27 81 4 4 0
STXBP3 STXBP3 O00186 Syntaxin-binding protein 3 chr1 Not Cancer Driver No 1 hippie, biogrid 59 64 9 9 0
SYNJ2BP SYNJ2BP P57105 Synaptojanin-2-binding protein chr14 Not Cancer Driver No 1 hippie, biogrid 27 12 4 4 0
TBC1D15 TBC1D15 Q8TC07 TBC1 domain family member 15 chr12 Not Cancer Driver No 1 hippie, biogrid 90 135 23 23 0
THADA_ENST00000405975 THADA Q6YHU6 Thyroid adenoma-associated protein chr2 Not Cancer Driver No 1 hippie, biogrid 204 63 6 6 0
THEM6 THEM6 Q8WUY1 Protein THEM6 chr8 Not Cancer Driver No 1 hippie, biogrid 3 7 0 0 0
TM9SF1 TM9SF1 O15321 Transmembrane 9 superfamily member 1 chr14 Not Cancer Driver No 1 hippie, biogrid 74 15 4 4 0
TM9SF3 TM9SF3 Q9HD45 Transmembrane 9 superfamily member 3 chr10 Not Cancer Driver No 1 hippie, biogrid 57 2 0 0 0
TMCO1 TMCO1 Q9UM00 Calcium load-activated calcium channel chr1 Not Cancer Driver No 1 hippie, biogrid 31 49 5 5 0
TMED1 TMED1 Q13445 Transmembrane emp24 domain-containing protein 1 chr19 Not Cancer Driver No 1 hippie, biogrid 26 26 3 3 0
TMED5 TMED5 Q9Y3A6 Transmembrane emp24 domain-containing protein 5 chr1 Not Cancer Driver No 1 hippie, biogrid 23 1 0 0 0
TMEM126A TMEM126A Q9H061 Transmembrane protein 126A chr11 Not Cancer Driver No 1 hippie, biogrid 18 7 1 1 0
TMEM160 TMEM160 Q9NX00 Transmembrane protein 160 chr19 Not Cancer Driver No 1 hippie, biogrid 8 46 1 1 0
TMEM259 TMEM259 Q4ZIN3 Membralin chr19 Not Cancer Driver No 1 hippie, biogrid 40 188 9 9 0
TNPO2 TNPO2 O14787 Transportin-2 chr19 Not Cancer Driver No 1 hippie, biogrid 99 76 10 10 0
TNPO3 TNPO3 Q9Y5L0 Transportin-3 chr7 Not Cancer Driver No 1 hippie, biogrid 122 12 1 1 1
TRIP6 TRIP6 Q15654 Thyroid receptor-interacting protein 6 chr7 Not Cancer Driver No 1 hippie 62 268 19 19 0
TSG101 TSG101 Q99816 Tumor susceptibility gene 101 protein chr11 Not Cancer Driver No 1 hippie, biogrid 46 159 23 23 0
TSPAN15 TSPAN15 O95858 Tetraspanin-15 chr10 Not Cancer Driver No 1 hippie, biogrid 29 0 0 0 0
TSPAN3 TSPAN3 O60637 Tetraspanin-3 chr15 Not Cancer Driver No 1 hippie, biogrid 23 0 0 0 0
TTI1 TTI1 O43156 TELO2-interacting protein 1 homolog chr20 Not Cancer Driver No 1 hippie, biogrid 136 93 13 13 0
TTYH2 TTYH2 Q9BSA4 Protein tweety homolog 2 chr17 Not Cancer Driver No 1 hippie, biogrid 63 68 19 19 0
TTYH3 TTYH3 Q9C0H2 Protein tweety homolog 3 chr7 Not Cancer Driver No 2 intact, hippie, biogrid 48 91 14 14 0
VPS28_ENST00000292510 VPS28 Q9UK41 Vacuolar protein sorting-associated protein 28 homolog chr8 Not Cancer Driver No 1 hippie, biogrid 28 31 5 5 0
VPS37A VPS37A Q8NEZ2 Vacuolar protein sorting-associated protein 37A chr8 Not Cancer Driver No 1 hippie, biogrid 41 153 19 19 1
WWP2 WWP2 O00308 NEDD4-like E3 ubiquitin-protein ligase WWP2 chr16 Not Cancer Driver No 1 hippie 112 422 57 57 0
XPO4 XPO4 Q9C0E2 Exportin-4 chr13 Not Cancer Driver No 1 hippie, biogrid 124 66 5 5 0
YIPF3 YIPF3 Q9GZM5 Protein YIPF3 chr6 Not Cancer Driver No 1 hippie, biogrid 38 87 13 13 0
ZMYM3 ZMYM3 Q14202 Zinc finger MYM-type protein 3 chrX Census Yes 1 hippie, biogrid 203 538 90 90 0