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S100A4_ENST00000354332 ,S100A4 ,P26447
  • Uniprot Accession= P26447
  • Ensembl Transcript= ENST00000354332.8
  • Uniprot Name= S100A4
  • Name= Protein S100-A4
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 0
  • Number of Interaction partner in biogrid: 66
  • Number of Interaction partner in hippie: 141
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ACTA1 ACTA1 P68133 Actin, alpha skeletal muscle chr1 Not Cancer Driver No 1 hippie 70 48 14 14 84
AGER_ENST00000375076 AGER Q15109 Advanced glycosylation end product-specific receptor chr6 Not Cancer Driver No 1 hippie 31 297 21 21 0
ANXA2_ENST00000396024 ANXA2 P07355 Annexin A2 chr15 Not Cancer Driver No 1 hippie 49 20 4 4 0
AREG AREG P15514 Amphiregulin chr4 Not Cancer Driver No 1 hippie 28 149 20 20 0
BAG6 BAG6 P46379 Large proline-rich protein BAG6 chr6 Not Cancer Driver No 1 hippie, biogrid 98 861 79 79 0
BBX BBX Q8WY36 HMG box transcription factor BBX chr3 Not Cancer Driver No 1 hippie 147 842 125 125 0
BCKDHA BCKDHA P12694 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial chr19 Not Cancer Driver No 1 hippie, biogrid 53 121 18 18 11
BCKDHB BCKDHB P21953 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial chr6 Not Cancer Driver No 1 hippie, biogrid 47 23 3 3 5
BEX2_ENST00000372677 BEX2 Q9BXY8 Protein BEX2 chrX Not Cancer Driver No 1 hippie, biogrid 23 105 13 13 0
BMI1 BMI1 P35226 Polycomb complex protein BMI-1 chr10 Not Cancer Driver No 1 hippie 50 150 30 30 0
BRD1_ENST00000216267 BRD1 O95696 Bromodomain-containing protein 1 chr22 Not Cancer Driver No 1 hippie 171 425 68 68 0
BRD4 BRD4 O60885 Bromodomain-containing protein 4 chr19 Census, Compendium Yes 1 hippie 193 1182 172 172 0
BTC BTC P35070 Probetacellulin chr4 Not Cancer Driver No 1 hippie 29 12 5 5 0
BTF3 BTF3 P20290 Transcription factor BTF3 chr5 Not Cancer Driver No 1 hippie 27 192 24 24 0
CACYBP CACYBP Q9HB71 Calcyclin-binding protein chr1 Not Cancer Driver No 1 hippie 27 92 10 10 0
CCDC14 CCDC14 Q49A88-6 Isoform 6 of Coiled-coil domain-containing protein 14 chr3 Not Cancer Driver No 1 hippie, biogrid 88 585 61 61 0
CCDC28A CCDC28A Q8IWP9 Coiled-coil domain-containing protein 28A chr6 Not Cancer Driver No 1 hippie, biogrid 50 198 28 28 0
CCDC28B_ENST00000373602 CCDC28B Q9BUN5 Coiled-coil domain-containing protein 28B chr1 Not Cancer Driver No 1 hippie, biogrid 26 165 21 21 0
CCN3 CCN3 P48745 CCN family member 3 chr8 Not Cancer Driver No 1 hippie 66 19 1 1 0
CDK2 CDK2 P24941 Cyclin-dependent kinase 2 chr12 Not Cancer Driver No 1 hippie 24 0 0 0 0
CEP128_ENST00000281129 CEP128 Q6ZU80 Centrosomal protein of 128 kDa chr14 Not Cancer Driver No 1 hippie, biogrid 195 897 167 167 0
CEP170 CEP170 Q5SW79 Centrosomal protein of 170 kDa chr1 Not Cancer Driver No 1 hippie, biogrid 264 1429 246 246 0
CEP44_ENST00000296519 CEP44 Q9C0F1 Centrosomal protein of 44 kDa chr4 Not Cancer Driver No 1 hippie, biogrid 55 142 17 17 0
CEP76 CEP76 Q8TAP6 Centrosomal protein of 76 kDa chr18 Not Cancer Driver No 1 hippie 63 96 7 7 0
CHMP4C CHMP4C Q96CF2 Charged multivesicular body protein 4c chr8 Not Cancer Driver No 1 hippie 33 224 31 31 0
CNTRL_ENST00000238341 CNTRL Q7Z7A1 Centriolin chr9 Census Yes 1 hippie 234 1556 159 159 0
CORO7 CORO7 P57737 Coronin-7 chr16 Not Cancer Driver No 1 hippie 108 347 38 38 0
CRBN CRBN Q96SW2 Protein cereblon chr3 Not Cancer Driver No 1 hippie, biogrid 52 76 10 10 1
DIAPH3 DIAPH3 Q9NSV4 Protein diaphanous homolog 3 chr13 Not Cancer Driver No 1 hippie, biogrid 189 492 78 78 0
DNAJA3 DNAJA3 Q96EY1 DnaJ homolog subfamily A member 3, mitochondrial chr16 Not Cancer Driver No 1 hippie 50 152 21 21 0
DNAJB6 DNAJB6 O75190 DnaJ homolog subfamily B member 6 chr7 Not Cancer Driver No 1 hippie 33 198 17 17 3
DPYSL4 DPYSL4 O14531 Dihydropyrimidinase-related protein 4 chr10 Not Cancer Driver No 1 hippie, biogrid 105 102 15 15 0
DYNLL1_ENST00000242577 DYNLL1 P63167 Dynein light chain 1, cytoplasmic chr12 Not Cancer Driver No 1 hippie 9 0 0 0 0
EBF2 EBF2 Q9HAK2 Transcription factor COE2 chr8 Not Cancer Driver No 1 hippie, biogrid 158 261 71 71 0
EGF EGF P01133 Pro-epidermal growth factor chr4 Not Cancer Driver No 1 hippie 184 191 25 25 1
EGFR EGFR P00533 Epidermal growth factor receptor chr7 Census, Compendium Yes 1 hippie 444 223 35 35 1
ERBB3 ERBB3 P21860 Receptor tyrosine-protein kinase erbB-3 chr12 Census, Compendium Yes 1 hippie 298 396 70 70 3
ERBB4 ERBB4 Q15303 Receptor tyrosine-protein kinase erbB-4 chr2 Census, Compendium Yes 1 hippie 428 323 116 116 2
ESCO2 ESCO2 Q56NI9 N-acetyltransferase ESCO2 chr8 Not Cancer Driver No 1 hippie 67 292 32 32 1
ESS2 ESS2 Q96DF8 Splicing factor ESS-2 homolog chr22 Not Cancer Driver No 1 hippie 71 458 68 68 0
EZR EZR P15311 Ezrin chr6 Census Yes 1 hippie 66 295 35 35 0
FAM24B_ENST00000368896 FAM24B Q8N5W8 Protein FAM24B chr10 Not Cancer Driver No 1 hippie, biogrid 9 0 0 0 0
FCGR3A_ENST00000443193 FCGR3A P08637 Low affinity immunoglobulin gamma Fc region receptor III-A chr1 Not Cancer Driver No 1 hippie 69 0 0 0 1
GAK GAK O14976 Cyclin-G-associated kinase chr4 Not Cancer Driver No 1 hippie, biogrid 146 589 79 79 0
GAN GAN Q9H2C0 Gigaxonin chr16 Not Cancer Driver No 1 hippie, biogrid 74 33 6 6 19
GFER GFER P55789 FAD-linked sulfhydryl oxidase ALR chr16 Not Cancer Driver No 1 hippie, biogrid 10 97 4 4 1
GOLGA2_ENST00000611957 GOLGA2 Q08379 Golgin subfamily A member 2 chr9 Not Cancer Driver No 1 hippie, biogrid 115 854 96 96 0
HAUS1 HAUS1 Q96CS2 HAUS augmin-like complex subunit 1 chr18 Not Cancer Driver No 1 hippie, biogrid 47 60 11 11 0
HAUS4 HAUS4 Q9H6D7 HAUS augmin-like complex subunit 4 chr14 Not Cancer Driver No 1 hippie, biogrid 42 2 0 0 0
HBEGF HBEGF Q99075 Proheparin-binding EGF-like growth factor chr5 Not Cancer Driver No 1 hippie 16 63 3 3 0
HSBP1_ENST00000570259 HSBP1 O75506 Heat shock factor-binding protein 1 chr16 Not Cancer Driver No 1 hippie, biogrid 6 76 6 6 0
HSPB1 HSPB1 P04792 Heat shock protein beta-1 chr7 Not Cancer Driver No 1 hippie 10 118 8 8 20
HTRA4 HTRA4 P83105 Serine protease HTRA4 chr8 Not Cancer Driver No 1 hippie 57 15 0 0 0
IGBP1_ENST00000356413 IGBP1 P78318 Immunoglobulin-binding protein 1 chrX Not Cancer Driver No 1 hippie, biogrid 51 193 28 28 0
KAT7 KAT7 O95251 Histone acetyltransferase KAT7 chr17 Census Yes 1 hippie 97 327 47 47 0
KIF18B KIF18B Q86Y91 Kinesin-like protein KIF18B chr17 Not Cancer Driver No 1 hippie, biogrid 100 590 69 69 0
MATR3_ENST00000509990 MATR3 P43243 Matrin-3 chr5 Not Cancer Driver No 1 hippie 98 611 68 68 3
MDM2_ENST00000539479 MDM2 Q00987 E3 ubiquitin-protein ligase Mdm2 chr12 Census, Compendium Yes 1 hippie 56 297 37 37 0
METAP2 METAP2 P50579 Methionine aminopeptidase 2 chr12 Not Cancer Driver No 1 hippie 54 176 19 19 0
MKNK1 MKNK1 Q9BUB5 MAP kinase-interacting serine/threonine-protein kinase 1 chr1 Not Cancer Driver No 1 hippie 54 149 24 24 0
MOV10_ENST00000357443 MOV10 Q9HCE1 Helicase MOV-10 chr1 Not Cancer Driver No 1 hippie 110 101 8 8 0
MYH10_ENST00000269243 MYH10 P35580 Myosin-10 chr17 Not Cancer Driver No 1 hippie 258 1134 136 136 0
MYH14_ENST00000596571 MYH14 Q7Z406 Myosin-14 chr19 Not Cancer Driver No 1 hippie, biogrid 275 1215 169 169 5
MYH2_ENST00000397183 MYH2 Q9UKX2 Myosin-2 chr17 Not Cancer Driver No 1 hippie 572 1073 338 338 1
MYH4 MYH4 Q9Y623 Myosin-4 chr17 Not Cancer Driver No 1 hippie 464 1138 288 288 0
MYH9 MYH9 P35579 Myosin-9 chr22 Census, Compendium Yes 2 hippie, biogrid 310 1120 160 160 17
MYL12A_ENST00000217652 MYL12A P19105 Myosin regulatory light chain 12A chr18 Not Cancer Driver No 1 hippie, biogrid 19 70 13 13 0
NME7 NME7 Q9Y5B8 Nucleoside diphosphate kinase 7 chr1 Not Cancer Driver No 1 hippie, biogrid 53 0 0 0 0
NPAT NPAT Q14207 Protein NPAT chr11 Not Cancer Driver No 1 hippie 134 1149 113 113 0
NR2C2_ENST00000393102 NR2C2 P49116 Nuclear receptor subfamily 2 group C member 2 chr3 Not Cancer Driver No 1 hippie 62 186 24 24 0
NRG1_ENST00000405005 NRG1 Q02297 Pro-neuregulin-1, membrane-bound isoform chr8 Census, Compendium Yes 1 hippie 159 528 132 132 0
NXF1_ENST00000294172 NXF1 Q9UBU9 Nuclear RNA export factor 1 chr11 Compendium Yes 1 hippie 100 163 32 32 0
OIP5 OIP5 O43482 Protein Mis18-beta chr15 Not Cancer Driver No 1 hippie, biogrid 31 65 7 7 0
PATE2 PATE2 Q6UY27 Prostate and testis expressed protein 2 chr11 Not Cancer Driver No 1 hippie, biogrid 18 0 0 0 0
PEBP1 PEBP1 P30086 Phosphatidylethanolamine-binding protein 1 chr12 Not Cancer Driver No 1 hippie 23 76 13 13 0
PHF12 PHF12 Q96QT6 PHD finger protein 12 chr17 Not Cancer Driver No 1 hippie 107 619 68 68 0
PKN3 PKN3 Q6P5Z2 Serine/threonine-protein kinase N3 chr9 Not Cancer Driver No 1 hippie, biogrid 99 392 49 49 0
POP4 POP4 O95707 Ribonuclease P protein subunit p29 chr19 Not Cancer Driver No 1 hippie 25 53 9 9 0
POTEI POTEI P0CG38 POTE ankyrin domain family member I chr2 Not Cancer Driver No 1 hippie, biogrid 14 449 6 6 0
POU4F3 POU4F3 Q15319 POU domain, class 4, transcription factor 3 chr5 Not Cancer Driver No 1 hippie, biogrid 62 198 39 39 10
PPFIBP1 PPFIBP1 Q86W92 Liprin-beta-1 chr12 Census Yes 2 hippie, biogrid 110 555 57 57 0
PSMA1_ENST00000396394 PSMA1 P25786 Proteasome subunit alpha type-1 chr11 Not Cancer Driver No 1 hippie, biogrid 48 51 9 9 0
PTGR2 PTGR2 Q8N8N7 Prostaglandin reductase 2 chr14 Not Cancer Driver No 1 hippie 26 22 2 2 0
PXDN PXDN Q92626 Peroxidasin homolog chr2 Not Cancer Driver No 1 hippie, biogrid 332 307 77 77 1
RAB5A RAB5A P20339 Ras-related protein Rab-5A chr3 Not Cancer Driver No 1 hippie 32 65 15 15 0
RASA1 RASA1 P20936 Ras GTPase-activating protein 1 chr5 Compendium Yes 1 hippie 154 181 25 25 3
RCBTB1 RCBTB1 Q8NDN9 RCC1 and BTB domain-containing protein 1 chr13 Not Cancer Driver No 1 hippie, biogrid 54 11 4 4 4
RCBTB2_ENST00000344532 RCBTB2 O95199 RCC1 and BTB domain-containing protein 2 chr13 Not Cancer Driver No 1 hippie, biogrid 86 36 3 3 0
RHOA RHOA P61586 Transforming protein RhoA chr3 Census, Compendium Yes 1 hippie 99 46 13 13 2
RHOU RHOU Q7L0Q8 Rho-related GTP-binding protein RhoU chr1 Not Cancer Driver No 1 hippie 34 63 6 6 0
RIPK1_ENST00000380409 RIPK1 Q13546 Receptor-interacting serine/threonine-protein kinase 1 chr6 Compendium Yes 1 hippie 82 277 39 39 4
RIPPLY3 RIPPLY3 P57055 Protein ripply3 chr21 Not Cancer Driver No 1 hippie, biogrid 44 190 44 44 0
RPRD2 RPRD2 Q5VT52 Regulation of nuclear pre-mRNA domain-containing protein 2 chr1 Not Cancer Driver No 1 hippie, biogrid 184 1225 156 156 0
RPS6KA1_ENST00000374168 RPS6KA1 Q15418 Ribosomal protein S6 kinase alpha-1 chr1 Not Cancer Driver No 1 hippie 94 178 32 32 0
S100A1 S100A1 P23297 Protein S100-A1 chr1 Not Cancer Driver No 1 hippie 13 9 0 0 0
S100A2_ENST00000368709 S100A2 P29034 Protein S100-A2 chr1 Not Cancer Driver No 1 hippie, biogrid 16 6 2 2 0
S100A4_ENST00000354332 S100A4 P26447 Protein S100-A4 chr1 Not Cancer Driver No 1 hippie 9 6 2 2 0
S100A6_ENST00000496817 S100A6 P06703 Protein S100-A6 chr1 Not Cancer Driver No 1 hippie 5 4 0 0 0
S100B S100B P04271 Protein S100-B chr21 Not Cancer Driver No 1 hippie 17 13 1 1 0
S100P S100P P25815 Protein S100-P chr4 Not Cancer Driver No 1 hippie 7 3 1 1 0
SATB1_ENST00000454909 SATB1 Q01826 DNA-binding protein SATB1 chr3 Compendium Yes 1 hippie, biogrid 130 482 84 84 12
SATB2 SATB2 Q9UPW6 DNA-binding protein SATB2 chr2 Not Cancer Driver No 1 hippie, biogrid 164 412 100 100 0
SELENBP1_ENST00000368868 SELENBP1 Q13228 Methanethiol oxidase chr1 Not Cancer Driver No 1 hippie, biogrid 67 32 5 5 2
SLC8A1_ENST00000332839 SLC8A1 P32418 Sodium/calcium exchanger 1 chr2 Not Cancer Driver No 1 hippie 305 158 48 48 0
SMAD2_ENST00000402690 SMAD2 Q15796 Mothers against decapentaplegic homolog 2 chr18 Census, Compendium Yes 1 hippie 79 137 12 12 0
SMAD3 SMAD3 P84022 Mothers against decapentaplegic homolog 3 chr15 Census, Compendium Yes 1 hippie 97 111 19 19 5
SNRPF SNRPF P62306 Small nuclear ribonucleoprotein F chr12 Not Cancer Driver No 1 hippie, biogrid 4 10 0 0 0
SPATA5 SPATA5 Q8NB90 ATPase family protein 2 homolog chr4 Not Cancer Driver No 1 hippie, biogrid 101 165 16 16 10
SPC24 SPC24 Q8NBT2 Kinetochore protein Spc24 chr19 Not Cancer Driver No 1 hippie, biogrid 9 88 5 5 0
SPC25 SPC25 Q9HBM1 Kinetochore protein Spc25 chr2 Not Cancer Driver No 1 hippie, biogrid 15 34 2 2 0
SRPK2_ENST00000489828 SRPK2 P78362 SRSF protein kinase 2 chr7 Not Cancer Driver No 1 hippie 78 343 46 46 0
SSNA1 SSNA1 O43805 Sjoegren syndrome nuclear autoantigen 1 chr9 Not Cancer Driver No 1 hippie, biogrid 11 74 10 10 0
ST6GALNAC6_ENST00000373146 ST6GALNAC6 Q969X2 Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 chr9 Not Cancer Driver No 1 hippie, biogrid 44 86 13 13 0
STXBP2_ENST00000221283 STXBP2 Q15833 Syntaxin-binding protein 2 chr19 Not Cancer Driver No 1 hippie, biogrid 77 80 13 13 5
SUGT1 SUGT1 Q9Y2Z0 Protein SGT1 homolog chr13 Not Cancer Driver No 1 hippie, biogrid 31 119 5 5 0
SUV39H1_ENST00000376687 SUV39H1 O43463 Histone-lysine N-methyltransferase SUV39H1 chrX Not Cancer Driver No 1 hippie 59 15 1 1 0
SYNE2_ENST00000344113 SYNE2 Q8WXH0 Nesprin-2 chr14 Not Cancer Driver No 1 hippie 779 1888 220 220 1
TNF TNF P01375 Tumor necrosis factor chr6 Not Cancer Driver No 1 hippie 24 45 3 3 0
TOM1L2 TOM1L2 Q6ZVM7 TOM1-like protein 2 chr17 Not Cancer Driver No 1 hippie, biogrid 57 335 37 37 0
TP53_ENST00000445888 TP53 P04637 Cellular tumor antigen p53 chr17 Census, Compendium Yes 1 hippie 2891 282 1466 1466 83
TPM2 TPM2 P07951 Tropomyosin beta chain chr9 Not Cancer Driver No 1 hippie 39 232 35 35 15
TPM3 TPM3 P06753 Tropomyosin alpha-3 chain chr1 Census Yes 1 hippie 35 230 27 27 21
TRIP13 TRIP13 Q15645 Pachytene checkpoint protein 2 homolog chr5 Not Cancer Driver No 1 hippie 62 30 6 6 1
TRPM4 TRPM4 Q8TD43 Transient receptor potential cation channel subfamily M member 4 chr19 Not Cancer Driver No 1 hippie 152 149 18 18 12
TTC21B TTC21B Q7Z4L5 Tetratricopeptide repeat protein 21B chr2 Not Cancer Driver No 1 hippie, biogrid 176 73 14 14 11
TXNIP TXNIP Q9H3M7 Thioredoxin-interacting protein chr1 Not Cancer Driver No 1 hippie, biogrid 61 77 14 14 0
UBE3A UBE3A Q05086 Ubiquitin-protein ligase E3A chr15 Not Cancer Driver No 1 hippie, biogrid 141 136 22 22 0
UMPS UMPS P11172 Uridine 5'-monophosphate synthase chr3 Not Cancer Driver No 1 hippie, biogrid 58 18 2 2 3
UNC119 UNC119 Q13432 Protein unc-119 homolog A chr17 Not Cancer Driver No 1 hippie, biogrid 20 89 4 4 1
UNK UNK Q9C0B0 RING finger protein unkempt homolog chr17 Not Cancer Driver No 1 hippie, biogrid 79 511 46 46 0
UQCR10 UQCR10 Q9UDW1 Cytochrome b-c1 complex subunit 9 chr22 Not Cancer Driver No 1 hippie 12 0 0 0 0
VCPIP1 VCPIP1 Q96JH7 Deubiquitinating protein VCPIP1 chr8 Not Cancer Driver No 1 hippie, biogrid 133 543 61 61 0
VPS11 VPS11 Q9H270 Vacuolar protein sorting-associated protein 11 homolog chr11 Not Cancer Driver No 1 hippie, biogrid 96 118 6 6 1
VPS39 VPS39 Q96JC1 Vam6/Vps39-like protein chr15 Not Cancer Driver No 1 hippie, biogrid 101 51 6 6 0
VWA8 VWA8 A3KMH1 von Willebrand factor A domain-containing protein 8 chr13 Not Cancer Driver No 1 hippie, biogrid 246 384 36 36 0
WDFY3 WDFY3 Q8IZQ1 WD repeat and FYVE domain-containing protein 3 chr4 Not Cancer Driver No 1 hippie 455 605 73 73 1
XIAP_ENST00000434753 XIAP P98170 E3 ubiquitin-protein ligase XIAP chrX Not Cancer Driver No 1 hippie 89 55 6 6 0
XRCC4 XRCC4 Q13426 DNA repair protein XRCC4 chr5 Not Cancer Driver No 1 hippie, biogrid 47 171 31 31 3
ZBED1 ZBED1 O96006 E3 SUMO-protein ligase ZBED1 chrX Not Cancer Driver No 1 hippie, biogrid 137 97 12 12 0
ZFHX4_ENST00000518282 ZFHX4 Q86UP3 Zinc finger homeobox protein 4 chr8 Not Cancer Driver No 1 hippie, biogrid 1301 2494 885 885 0
ZZEF1 ZZEF1 O43149 Zinc finger ZZ-type and EF-hand domain-containing protein 1 chr17 Not Cancer Driver No 1 hippie 292 580 69 69 0