Interactions

Identifier	UniProt Gene	UniProt Accession	UniProt Name	Chromosome	Cancer Database	Cancer Driver	Number of independent pubication	Interaction Database	Number of missense mutations	Number of disordered residues	Number of mutations in disordered residues	Number of mutations in disordered residues	Number of omim mutations
ACTB_ENST00000646664	ACTB	P60709	Actin, cytoplasmic 1	chr7	Not Cancer Driver	No	1	hippie, biogrid	112	43	5	5	5
APOC3	APOC3	P02656	Apolipoprotein C-III	chr11	Not Cancer Driver	No	1	intact, hippie, biogrid	14	12	2	2	1
ARMC5_ENST00000563544	ARMC5	Q96C12	Armadillo repeat-containing protein 5	chr16	Not Cancer Driver	No	1	hippie, biogrid	135	267	41	41	17
ARMCX3_ENST00000537169	ARMCX3	Q9UH62	Armadillo repeat-containing X-linked protein 3	chrX	Not Cancer Driver	No	1	hippie, biogrid	39	77	7	7	0
ASB6	ASB6	Q9NWX5	Ankyrin repeat and SOCS box protein 6	chr9	Not Cancer Driver	No	2	intact, hippie, biogrid	35	31	3	3	0
BRCA1_ENST00000357654	BRCA1	P38398	Breast cancer type 1 susceptibility protein	chr17	Census, Compendium	Yes	1	hippie	224	1458	174	174	35
BRD1_ENST00000216267	BRD1	O95696	Bromodomain-containing protein 1	chr22	Not Cancer Driver	No	1	hippie	171	425	68	68	0
CCNF	CCNF	P41002	Cyclin-F	chr16	Not Cancer Driver	No	1	hippie, biogrid	106	221	23	23	3
CCT5	CCT5	P48643	T-complex protein 1 subunit epsilon	chr5	Not Cancer Driver	No	1	hippie, biogrid	83	72	10	10	1
CCT8L2	CCT8L2	Q96SF2	T-complex protein 1 subunit theta-like 2	chr22	Not Cancer Driver	No	1	hippie, biogrid	216	104	46	46	0
CDK19	CDK19	Q9BWU1	Cyclin-dependent kinase 19	chr6	Not Cancer Driver	No	1	hippie, biogrid	63	191	28	28	8
CEP120	CEP120	Q8N960	Centrosomal protein of 120 kDa	chr5	Not Cancer Driver	No	1	hippie	102	448	52	52	1
CNTRL_ENST00000238341	CNTRL	Q7Z7A1	Centriolin	chr9	Census	Yes	1	hippie	234	1556	159	159	0
CPNE2_ENST00000535318	CPNE2	Q96FN4	Copine-2	chr16	Not Cancer Driver	No	2	intact, hippie, biogrid	62	32	4	4	0
CRCP	CRCP	O75575	DNA-directed RNA polymerase III subunit RPC9	chr7	Not Cancer Driver	No	1	hippie, biogrid	11	113	4	4	0
DNM2_ENST00000355667	DNM2	P50570	Dynamin-2	chr19	Census	Yes	1	hippie, biogrid	138	270	43	43	22
DXO_ENST00000375356	DXO	O77932	Decapping and exoribonuclease protein	chr6	Not Cancer Driver	No	3	hippie, biogrid	46	143	17	17	0
EGLN3	EGLN3	Q9H6Z9	Prolyl hydroxylase EGLN3	chr14	Not Cancer Driver	No	1	hippie	33	13	0	0	0
EHBP1	EHBP1	Q8NDI1	EH domain-binding protein 1	chr2	Not Cancer Driver	No	1	hippie, biogrid	148	914	115	115	0
EIF4A2	EIF4A2	Q14240	Eukaryotic initiation factor 4A-II	chr3	Census	Yes	1	hippie, biogrid	77	27	14	14	0
EP300	EP300	Q09472	Histone acetyltransferase p300	chr22	Census, Compendium	Yes	1	hippie	334	1790	196	196	1
FAM168A	FAM168A	Q92567	Protein FAM168A	chr11	Not Cancer Driver	No	1	hippie, biogrid	17	139	11	11	0
FGF11	FGF11	Q92914	Fibroblast growth factor 11	chr17	Not Cancer Driver	No	1	hippie, biogrid	20	68	5	5	0
FGFR1OP	CEP43	O95684	Centrosomal protein 43	chr6	Not Cancer Driver	No	1	intact	43	272	33	33	0
G3BP1	G3BP1	Q13283	Ras GTPase-activating protein-binding protein 1	chr5	Not Cancer Driver	No	1	intact, hippie, biogrid	85	352	65	65	0
GCOM1_ENST00000380569	GCOM1	P0CAP1-11	Isoform 11 of Myocardial zonula adherens protein	chr15	Not Cancer Driver	No	1	hippie	96	462	83	83	0
GPN1_ENST00000610189	GPN1	Q9HCN4	GPN-loop GTPase 1	chr2	Not Cancer Driver	No	3	hippie, biogrid	39	117	14	14	0
GPN3_ENST00000228827	GPN3	Q9UHW5	GPN-loop GTPase 3	chr12	Not Cancer Driver	No	5	intact, hippie, biogrid	28	19	0	0	0
GTF3C3	GTF3C3	Q9Y5Q9	General transcription factor 3C polypeptide 3	chr2	Not Cancer Driver	No	1	hippie, biogrid	109	195	22	22	0
HELLS_ENST00000348459	HELLS	Q9NRZ9	Lymphoid-specific helicase	chr10	Not Cancer Driver	No	1	hippie, biogrid	78	227	25	25	0
HNRNPL	HNRNPL	P14866	Heterogeneous nuclear ribonucleoprotein L	chr19	Not Cancer Driver	No	1	hippie	89	283	29	29	0
INTS1	INTS1	Q8N201	Integrator complex subunit 1	chr7	Not Cancer Driver	No	1	hippie, biogrid	234	368	43	43	1
INTS3_ENST00000435409	INTS3	Q68E01	Integrator complex subunit 3	chr1	Not Cancer Driver	No	1	hippie, biogrid	125	213	25	25	0
INTS4	INTS4	Q96HW7	Integrator complex subunit 4	chr11	Not Cancer Driver	No	1	hippie, biogrid	117	82	7	7	0
INTS7	INTS7	Q9NVH2	Integrator complex subunit 7	chr1	Not Cancer Driver	No	1	hippie, biogrid	106	88	17	17	0
ITCH	ITCH	Q96J02	E3 ubiquitin-protein ligase Itchy homolog	chr20	Not Cancer Driver	No	1	hippie	95	335	42	42	0
KHDRBS2	KHDRBS2	Q5VWX1	KH domain-containing, RNA-binding, signal transduction-associated protein 2	chr6	Not Cancer Driver	No	1	hippie, biogrid	168	268	140	140	0
KHDRBS3	KHDRBS3	O75525	KH domain-containing, RNA-binding, signal transduction-associated protein 3	chr8	Not Cancer Driver	No	1	hippie, biogrid	64	230	40	40	0
KRT8_ENST00000546897	KRT8	P05787	Keratin, type II cytoskeletal 8	chr12	Not Cancer Driver	No	1	hippie, biogrid	65	221	37	37	3
KSR2_ENST00000339824	KSR2	Q6VAB6	Kinase suppressor of Ras 2	chr12	Not Cancer Driver	No	1	intact, hippie	231	434	120	120	0
LMO2_ENST00000395833	LMO2	P25791	Rhombotin-2	chr11	Census	Yes	2	intact, hippie, biogrid	35	14	1	1	0
LRCH2	LRCH2	Q5VUJ6	Leucine-rich repeat and calponin homology domain-containing protein 2	chrX	Not Cancer Driver	No	1	hippie, biogrid	128	458	77	77	0
MAPRE3	MAPRE3	Q9UPY8	Microtubule-associated protein RP/EB family member 3	chr2	Not Cancer Driver	No	1	hippie, biogrid	37	120	16	16	0
MED1	MED1	Q15648	Mediator of RNA polymerase II transcription subunit 1	chr17	Not Cancer Driver	No	3	hippie, biogrid	162	1104	117	117	0
MED10	MED10	Q9BTT4	Mediator of RNA polymerase II transcription subunit 10	chr5	Not Cancer Driver	No	1	hippie, biogrid	14	13	3	3	0
MED13	MED13	Q9UHV7	Mediator of RNA polymerase II transcription subunit 13	chr17	Not Cancer Driver	No	1	hippie, biogrid	288	905	127	127	3
MED13L	MED13L	Q71F56	Mediator of RNA polymerase II transcription subunit 13-like	chr12	Not Cancer Driver	No	1	hippie, biogrid	274	1074	142	142	0
MED14	MED14	O60244	Mediator of RNA polymerase II transcription subunit 14	chrX	Not Cancer Driver	No	1	hippie, biogrid	182	318	45	45	0
MED15	MED15	Q96RN5	Mediator of RNA polymerase II transcription subunit 15	chr22	Not Cancer Driver	No	1	hippie, biogrid	95	558	72	72	0
MED17	MED17	Q9NVC6	Mediator of RNA polymerase II transcription subunit 17	chr11	Not Cancer Driver	No	3	hippie, biogrid	75	182	17	17	1
MED18_ENST00000398997	MED18	Q9BUE0	Mediator of RNA polymerase II transcription subunit 18	chr1	Not Cancer Driver	No	2	intact, hippie, biogrid	35	10	2	2	0
MED20	MED20	Q9H944	Mediator of RNA polymerase II transcription subunit 20	chr6	Not Cancer Driver	No	1	hippie, biogrid	22	0	0	0	0
MED21	MED21	Q13503	Mediator of RNA polymerase II transcription subunit 21	chr12	Not Cancer Driver	No	2	hippie, biogrid	12	46	3	3	0
MED22_ENST00000343730	MED22	Q15528	Mediator of RNA polymerase II transcription subunit 22	chr9	Not Cancer Driver	No	1	hippie, biogrid	26	98	12	12	0
MED24_ENST00000394128	MED24	O75448	Mediator of RNA polymerase II transcription subunit 24	chr17	Not Cancer Driver	No	1	hippie, biogrid	101	76	0	0	0
MED26	MED26	O95402	Mediator of RNA polymerase II transcription subunit 26	chr19	Not Cancer Driver	No	2	hippie, biogrid	71	541	61	61	0
MED27	MED27	Q6P2C8	Mediator of RNA polymerase II transcription subunit 27	chr9	Not Cancer Driver	No	1	hippie, biogrid	34	61	5	5	0
MED28	MED28	Q9H204	Mediator of RNA polymerase II transcription subunit 28	chr4	Not Cancer Driver	No	2	hippie, biogrid	24	101	18	18	0
MED30	MED30	Q96HR3	Mediator of RNA polymerase II transcription subunit 30	chr8	Not Cancer Driver	No	1	hippie, biogrid	20	93	8	8	0
MED31	MED31	Q9Y3C7	Mediator of RNA polymerase II transcription subunit 31	chr17	Not Cancer Driver	No	1	hippie, biogrid	16	15	1	1	0
MED4	MED4	Q9NPJ6	Mediator of RNA polymerase II transcription subunit 4	chr13	Not Cancer Driver	No	2	hippie, biogrid	29	161	17	17	0
MED6_ENST00000256379	MED6	O75586	Mediator of RNA polymerase II transcription subunit 6	chr14	Not Cancer Driver	No	1	hippie, biogrid	21	79	4	4	0
MED7	MED7	O43513	Mediator of RNA polymerase II transcription subunit 7	chr5	Not Cancer Driver	No	1	intact, hippie, biogrid	32	132	19	19	0
MED8_ENST00000372457	MED8	Q96G25	Mediator of RNA polymerase II transcription subunit 8	chr1	Not Cancer Driver	No	1	hippie, biogrid	29	191	24	24	0
MED9	MED9	Q9NWA0	Mediator of RNA polymerase II transcription subunit 9	chr17	Not Cancer Driver	No	2	hippie, biogrid	16	127	15	15	0
NEDD4	NEDD4	P46934	E3 ubiquitin-protein ligase NEDD4	chr15	Not Cancer Driver	No	1	hippie	150	711	79	79	0
NELFE	NELFE	P18615	Negative elongation factor E	chr6	Not Cancer Driver	No	1	hippie, biogrid	47	352	45	45	0
NEURL4	NEURL4	Q96JN8	Neuralized-like protein 4	chr17	Not Cancer Driver	No	1	intact, hippie	217	751	119	119	0
OFD1	OFD1	O75665	Oral-facial-digital syndrome 1 protein	chrX	Not Cancer Driver	No	1	hippie	129	476	58	58	5
PDRG1	PDRG1	Q9NUG6	p53 and DNA damage-regulated protein 1	chr20	Not Cancer Driver	No	2	hippie, biogrid	17	46	9	9	0
PFDN2	PFDN2	Q9UHV9	Prefoldin subunit 2	chr1	Not Cancer Driver	No	1	hippie, biogrid	18	111	11	11	0
PFN1	PFN1	P07737	Profilin-1	chr17	Not Cancer Driver	No	1	hippie, biogrid	16	7	1	1	3
PHRF1	PHRF1	Q9P1Y6	PHD and RING finger domain-containing protein 1	chr11	Not Cancer Driver	No	1	hippie	238	1414	194	194	0
PIH1D1	PIH1D1	Q9NWS0	PIH1 domain-containing protein 1	chr19	Not Cancer Driver	No	7	intact, hippie, biogrid	30	157	13	13	0
PLEKHF2	PLEKHF2	Q9H8W4	Pleckstrin homology domain-containing family F member 2	chr8	Not Cancer Driver	No	1	hippie	32	36	4	4	0
POLR1A	POLR1A	O95602	DNA-directed RNA polymerase I subunit RPA1	chr2	Not Cancer Driver	No	1	hippie, biogrid	208	361	64	64	2
POLR1B_ENST00000263331	POLR1B	Q9H9Y6	DNA-directed RNA polymerase I subunit RPA2	chr2	Not Cancer Driver	No	1	hippie, biogrid	120	69	10	10	2
POLR1C	POLR1C	O15160	DNA-directed RNA polymerases I and III subunit RPAC1	chr6	Not Cancer Driver	No	1	hippie, biogrid	34	28	3	3	13
POLR1D	POLR1D	P0DPB6	DNA-directed RNA polymerases I and III subunit RPAC2	chr13	Not Cancer Driver	No	1	hippie, biogrid	17	87	13	13	7
POLR1E	POLR1E	Q9GZS1	DNA-directed RNA polymerase I subunit RPA49	chr9	Not Cancer Driver	No	1	hippie, biogrid	39	85	6	6	0
POLR2A	POLR2A	P24928-2	Isoform 2 of DNA-directed RNA polymerase II subunit RPB1	chr17	Census	Yes	3	intact, hippie, biogrid	56	230	20	20	0
POLR2B_ENST00000314595	POLR2B	P30876	DNA-directed RNA polymerase II subunit RPB2	chr4	Not Cancer Driver	No	2	intact, hippie, biogrid	166	173	25	25	0
POLR2C	POLR2C	P19387	DNA-directed RNA polymerase II subunit RPB3	chr16	Not Cancer Driver	No	3	intact, hippie, biogrid	34	108	11	11	0
POLR2D	POLR2D	O15514	DNA-directed RNA polymerase II subunit RPB4	chr2	Not Cancer Driver	No	4	intact, hippie, biogrid	13	54	2	2	0
POLR2E	POLR2E	P19388	DNA-directed RNA polymerases I, II, and III subunit RPABC1	chr19	Not Cancer Driver	No	3	intact, hippie, biogrid	31	36	3	3	0
POLR2F_ENST00000442738	POLR2F	P61218	DNA-directed RNA polymerases I, II, and III subunit RPABC2	chr22	Not Cancer Driver	No	3	hippie, biogrid	22	57	13	13	0
POLR2G	POLR2G	P62487	DNA-directed RNA polymerase II subunit RPB7	chr11	Not Cancer Driver	No	6	intact, hippie, biogrid	15	15	1	1	0
POLR2H_ENST00000456318	POLR2H	P52434	DNA-directed RNA polymerases I, II, and III subunit RPABC3	chr3	Not Cancer Driver	No	2	intact, hippie, biogrid	16	14	1	1	0
POLR2I	POLR2I	P36954	DNA-directed RNA polymerase II subunit RPB9	chr19	Not Cancer Driver	No	1	intact, hippie, biogrid	21	22	5	5	0
POLR2J	POLR2J	P52435	DNA-directed RNA polymerase II subunit RPB11-a	chr7	Not Cancer Driver	No	3	intact, hippie, biogrid	12	0	0	0	0
POLR2J3	POLR2J3	Q9H1A7	DNA-directed RNA polymerase II subunit RPB11-b2	chr7	Not Cancer Driver	No	1	hippie, biogrid	3	0	0	0	0
POLR2K	POLR2K	P53803	DNA-directed RNA polymerases I, II, and III subunit RPABC4	chr8	Not Cancer Driver	No	1	hippie, biogrid	10	11	1	1	0
POLR2L	POLR2L	P62875	DNA-directed RNA polymerases I, II, and III subunit RPABC5	chr11	Not Cancer Driver	No	2	hippie, biogrid	10	0	0	0	0
POLR2M_ENST00000464277	POLR2M	Q6EEV4	DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5	chr15	Not Cancer Driver	No	4	intact, hippie, biogrid	4	121	4	4	0
POLR3A	POLR3A	O14802	DNA-directed RNA polymerase III subunit RPC1	chr10	Not Cancer Driver	No	2	hippie, biogrid	155	113	17	17	15
POLR3B	POLR3B	Q9NW08	DNA-directed RNA polymerase III subunit RPC2	chr12	Not Cancer Driver	No	2	hippie, biogrid	164	117	20	20	8
POLR3D	POLR3D	P05423	DNA-directed RNA polymerase III subunit RPC4	chr8	Not Cancer Driver	No	1	hippie, biogrid	33	303	24	24	0
POLR3E	POLR3E	Q9NVU0	DNA-directed RNA polymerase III subunit RPC5	chr16	Not Cancer Driver	No	2	hippie, biogrid	84	308	40	40	0
POLR3H_ENST00000396504	POLR3H	Q9Y535	DNA-directed RNA polymerase III subunit RPC8	chr22	Not Cancer Driver	No	1	hippie, biogrid	23	33	6	6	0
PPP1CA_ENST00000376745	PPP1CA	P62136	Serine/threonine-protein phosphatase PP1-alpha catalytic subunit	chr11	Not Cancer Driver	No	1	hippie, biogrid	38	27	6	6	0
PPP1CC_ENST00000335007	PPP1CC	P36873	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	chr12	Not Cancer Driver	No	3	hippie, biogrid	26	23	4	4	0
PRPF31	PRPF31	Q8WWY3	U4/U6 small nuclear ribonucleoprotein Prp31	chr19	Not Cancer Driver	No	1	hippie, biogrid	58	213	17	17	2
RAMP1	RAMP1	O60894	Receptor activity-modifying protein 1	chr2	Not Cancer Driver	No	1	hippie, biogrid	16	0	0	0	0
RECQL4	RECQL4	O94761	ATP-dependent DNA helicase Q4	chr8	Census, Compendium	Yes	1	hippie	138	608	71	71	1
RECQL5	RECQL5	O94762	ATP-dependent DNA helicase Q5	chr17	Not Cancer Driver	No	1	hippie, biogrid	132	495	71	71	0
RFC4_ENST00000296273	RFC4	P35249	Replication factor C subunit 4	chr3	Not Cancer Driver	No	1	hippie, biogrid	58	50	8	8	0
RNGTT	RNGTT	O60942	mRNA-capping enzyme	chr6	Not Cancer Driver	No	2	hippie, biogrid	69	112	12	12	0
RPAP3	RPAP3	Q9H6T3	RNA polymerase II-associated protein 3	chr12	Not Cancer Driver	No	2	hippie, biogrid	59	334	37	37	0
RPRD1A	RPRD1A	Q96P16	Regulation of nuclear pre-mRNA domain-containing protein 1A	chr18	Not Cancer Driver	No	2	intact, hippie, biogrid	49	86	16	16	0
RPRD1B	RPRD1B	Q9NQG5	Regulation of nuclear pre-mRNA domain-containing protein 1B	chr20	Not Cancer Driver	No	5	intact, hippie, biogrid	34	155	16	16	0
RPRD2	RPRD2	Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	chr1	Not Cancer Driver	No	1	intact, hippie, biogrid	184	1225	156	156	0
RUNX1_ENST00000344691	RUNX1	Q01196	Runt-related transcription factor 1	chr21	Census, Compendium	Yes	1	hippie	81	360	58	58	2
RUVBL2	RUVBL2	Q9Y230	RuvB-like 2	chr19	Not Cancer Driver	No	2	hippie, biogrid	62	100	13	13	0
RXRG	RXRG	P48443	Retinoic acid receptor RXR-gamma	chr1	Not Cancer Driver	No	1	hippie, biogrid	103	161	41	41	0
SCAF1	SCAF1	Q9H7N4	Splicing factor, arginine/serine-rich 19	chr19	Not Cancer Driver	No	1	hippie, biogrid	135	1307	134	134	0
SCAF4	SCAF4	O95104	SR-related and CTD-associated factor 4	chr21	Not Cancer Driver	No	1	hippie, biogrid	162	938	132	132	0
SIRT6	SIRT6	Q8N6T7	NAD-dependent protein deacylase sirtuin-6	chr19	Not Cancer Driver	No	1	hippie	33	164	12	12	0
SPRR1B	SPRR1B	P22528	Cornifin-B	chr1	Not Cancer Driver	No	1	intact, hippie, biogrid	24	73	20	20	0
SQSTM1	SQSTM1	Q13501	Sequestosome-1	chr5	Not Cancer Driver	No	1	hippie, biogrid	54	267	32	32	30
SUPT6H	SUPT6H	Q7KZ85	Transcription elongation factor SPT6	chr17	Not Cancer Driver	No	1	hippie, biogrid	222	761	107	107	0
SYDE1	SYDE1	Q6ZW31	Rho GTPase-activating protein SYDE1	chr19	Not Cancer Driver	No	2	hippie, biogrid	62	412	27	27	0
TCP1	TCP1	P17987	T-complex protein 1 subunit alpha	chr6	Not Cancer Driver	No	1	hippie, biogrid	54	55	10	10	0
TJP2_ENST00000377245	TJP2	Q9UDY2	Tight junction protein ZO-2	chr9	Not Cancer Driver	No	1	hippie, biogrid	149	919	113	113	1
TNFAIP6	TNFAIP6	P98066	Tumor necrosis factor-inducible gene 6 protein	chr2	Not Cancer Driver	No	1	hippie, biogrid	62	13	5	5	0
TNIP2	TNIP2	Q8NFZ5	TNFAIP3-interacting protein 2	chr4	Not Cancer Driver	No	1	hippie	43	316	36	36	0
TOPBP1	TOPBP1	Q92547	DNA topoisomerase 2-binding protein 1	chr3	Not Cancer Driver	No	1	hippie, biogrid	169	577	59	59	0
URI1	URI1	O94763	Unconventional prefoldin RPB5 interactor 1	chr19	Not Cancer Driver	No	3	hippie, biogrid	88	388	64	64	0
UXT_ENST00000333119	UXT	Q9UBK9	Protein UXT	chrX	Not Cancer Driver	No	4	intact, hippie, biogrid	21	17	1	1	0
VIM_ENST00000224237	VIM	P08670	Vimentin	chr10	Not Cancer Driver	No	1	hippie, biogrid	84	316	57	57	1
WWP1	WWP1	Q9H0M0	NEDD4-like E3 ubiquitin-protein ligase WWP1	chr8	Not Cancer Driver	No	1	hippie, biogrid	139	431	75	75	0
WWP2	WWP2	O00308	NEDD4-like E3 ubiquitin-protein ligase WWP2	chr16	Not Cancer Driver	No	2	hippie, biogrid	112	422	57	57	0
XPO1_ENST00000406957	XPO1	O14980	Exportin-1	chr2	Census, Compendium	Yes	1	hippie	140	33	9	9	0
YBX1	YBX1	P67809	Y-box-binding protein 1	chr1	Not Cancer Driver	No	1	hippie, biogrid	41	312	41	41	0
ZFC3H1	ZFC3H1	O60293	Zinc finger C3H1 domain-containing protein	chr12	Not Cancer Driver	No	2	hippie, biogrid	210	1025	115	115	0
ZNHIT2	ZNHIT2	Q9UHR6	Zinc finger HIT domain-containing protein 2	chr11	Not Cancer Driver	No	1	hippie	29	157	15	15	0

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