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RNF115 ,RNF115 ,Q9Y4L5
  • Uniprot Accession= Q9Y4L5
  • Ensembl Transcript= ENST00000582693.4
  • Uniprot Name= RNF115
  • Name= E3 ubiquitin-protein ligase RNF115
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 16
  • Number of Interaction partner in biogrid: 55
  • Number of Interaction partner in hippie: 103
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
A2ML1 A2ML1 A8K2U0 Alpha-2-macroglobulin-like protein 1 chr12 Not Cancer Driver No 1 hippie, biogrid 269 97 22 22 0
ACP7 ACP7 Q6ZNF0 Acid phosphatase type 7 chr19 Not Cancer Driver No 1 hippie 72 22 7 7 0
AKT1_ENST00000349310 AKT1 P31749 RAC-alpha serine/threonine-protein kinase chr14 Census, Compendium Yes 1 hippie 108 158 24 24 4
ALOX12B ALOX12B O75342 Arachidonate 12-lipoxygenase, 12R-type chr17 Not Cancer Driver No 1 hippie, biogrid 101 16 3 3 18
ANXA8L1 ANXA8L1 Q5VT79 Annexin A8-like protein 1 chr10 Not Cancer Driver No 1 hippie 5 37 0 0 0
APP APP P05067 Amyloid-beta precursor protein chr21 Not Cancer Driver No 1 hippie 128 418 71 71 17
ATN1_ENST00000396684 ATN1 P54259 Atrophin-1 chr12 Not Cancer Driver No 1 hippie 141 1176 139 139 6
ATP12A_ENST00000381946 ATP12A P54707 Potassium-transporting ATPase alpha chain 2 chr13 Not Cancer Driver No 1 hippie, biogrid 203 117 24 24 0
BAG6 BAG6 P46379 Large proline-rich protein BAG6 chr6 Not Cancer Driver No 1 hippie 98 861 79 79 0
BIRC2 BIRC2 Q13490 Baculoviral IAP repeat-containing protein 2 chr11 Not Cancer Driver No 1 hippie 69 83 9 9 0
CALML3 CALML3 P27482 Calmodulin-like protein 3 chr10 Not Cancer Driver No 1 hippie, biogrid 34 105 28 28 0
CALML5 CALML5 Q9NZT1 Calmodulin-like protein 5 chr10 Not Cancer Driver No 1 hippie, biogrid 34 98 21 21 0
CDK10 CDK10 Q15131 Cyclin-dependent kinase 10 chr16 Not Cancer Driver No 1 hippie 42 30 4 4 0
CHI3L2 CHI3L2 Q15782 Chitinase-3-like protein 2 chr1 Not Cancer Driver No 1 hippie, biogrid 70 20 4 4 0
CRYBG1 CRYBG1 Q9Y4K1 Beta/gamma crystallin domain-containing protein 1 chr6 Not Cancer Driver No 1 hippie 211 1006 124 124 0
CST3_ENST00000376925 CST3 P01034 Cystatin-C chr20 Not Cancer Driver No 1 hippie 17 31 1 1 2
CTSV CTSV O60911 Cathepsin L2 chr9 Not Cancer Driver No 1 hippie, biogrid 55 7 1 1 0
DAZAP2_ENST00000412716 DAZAP2 Q15038 DAZ-associated protein 2 chr12 Not Cancer Driver No 1 hippie 17 68 7 7 0
DDX39A DDX39A O00148 ATP-dependent RNA helicase DDX39A chr19 Not Cancer Driver No 1 hippie, biogrid 44 37 2 2 0
DNAJB2 DNAJB2 P25686 DnaJ homolog subfamily B member 2 chr2 Not Cancer Driver No 2 hippie, biogrid 51 239 40 40 1
DOCK4 DOCK4 Q8N1I0 Dedicator of cytokinesis protein 4 chr7 Not Cancer Driver No 1 hippie 331 397 80 80 0
DSG3 DSG3 P32926 Desmoglein-3 chr18 Not Cancer Driver No 1 hippie, biogrid 270 264 64 64 0
EGFR EGFR P00533 Epidermal growth factor receptor chr7 Census, Compendium Yes 1 hippie 444 223 35 35 1
ELAVL1 ELAVL1 Q15717 ELAV-like protein 1 chr19 Not Cancer Driver No 1 hippie 69 43 5 5 0
EVPL_ENST00000301607 EVPL Q92817 Envoplakin chr17 Not Cancer Driver No 1 hippie, biogrid 290 1222 169 169 0
FAM189A2 FAM189A2 Q15884 Protein FAM189A2 chr9 Not Cancer Driver No 1 intact, hippie 62 231 29 29 0
FBXW11 FBXW11 Q9UKB1 F-box/WD repeat-containing protein 11 chr5 Not Cancer Driver No 1 hippie 75 20 3 3 7
FCHSD1 FCHSD1 Q86WN1 F-BAR and double SH3 domains protein 1 chr5 Not Cancer Driver No 1 hippie, biogrid 78 434 50 50 0
FOLR3 FOLR3 P41439 Folate receptor gamma chr11 Not Cancer Driver No 1 hippie 58 15 4 4 0
GABRD GABRD O14764 Gamma-aminobutyric acid receptor subunit delta chr1 Not Cancer Driver No 2 hippie, biogrid 71 19 5 5 1
GLUL_ENST00000331872 GLUL P15104 Glutamine synthetase chr1 Not Cancer Driver No 1 hippie, biogrid 66 104 21 21 2
GSDMA GSDMA Q96QA5 Gasdermin-A chr17 Not Cancer Driver No 1 hippie, biogrid 67 87 15 15 0
HAL HAL P42357 Histidine ammonia-lyase chr12 Not Cancer Driver No 1 hippie, biogrid 98 34 6 6 4
HERC2 HERC2 O95714 E3 ubiquitin-protein ligase HERC2 chr15 Compendium Yes 2 intact, hippie, biogrid 718 971 150 150 1
HLA-DRA HLA-DRA P01903 HLA class II histocompatibility antigen, DR alpha chain chr6 Not Cancer Driver No 1 hippie, biogrid 52 12 1 1 0
HMGCS1_ENST00000433297 HMGCS1 Q01581 Hydroxymethylglutaryl-CoA synthase, cytoplasmic chr5 Not Cancer Driver No 1 hippie, biogrid 64 74 10 10 0
HMOX1 HMOX1 P09601 Heme oxygenase 1 chr22 Not Cancer Driver No 1 hippie, biogrid 46 81 13 13 0
HRAS HRAS P01112 GTPase HRas chr11 Census, Compendium Yes 1 hippie 107 16 4 4 18
IL1RN_ENST00000409930 IL1RN P18510 Interleukin-1 receptor antagonist protein chr2 Not Cancer Driver No 1 hippie, biogrid 34 17 7 7 0
IL36G IL36G Q9NZH8 Interleukin-36 gamma chr2 Not Cancer Driver No 1 hippie, biogrid 35 23 5 5 0
IL36RN_ENST00000346807 IL36RN Q9UBH0 Interleukin-36 receptor antagonist protein chr2 Not Cancer Driver No 1 hippie, biogrid 34 7 4 4 4
IVL IVL P07476 Involucrin chr1 Not Cancer Driver No 1 hippie, biogrid 115 585 115 115 0
KDELR1 KDELR1 P24390 ER lumen protein-retaining receptor 1 chr19 Not Cancer Driver No 2 intact, hippie, biogrid 32 0 0 0 0
KLK6 KLK6 Q92876 Kallikrein-6 chr19 Not Cancer Driver No 1 hippie, biogrid 62 28 12 12 0
LCN2_ENST00000277480 LCN2 P80188 Neutrophil gelatinase-associated lipocalin chr9 Not Cancer Driver No 1 hippie, biogrid 29 4 3 3 0
LGALS7B LGALS7B P47929 Galectin-7 chr19 Not Cancer Driver No 1 biogrid 14 54 5 5 0
LMBR1L LMBR1L Q6UX01 Protein LMBR1L chr12 Not Cancer Driver No 1 hippie 57 4 0 0 0
MAP1LC3B MAP1LC3B Q9GZQ8 Microtubule-associated proteins 1A/1B light chain 3B chr16 Not Cancer Driver No 1 intact 10 17 1 1 0
MAVS MAVS Q7Z434 Mitochondrial antiviral-signaling protein chr20 Not Cancer Driver No 1 hippie 70 411 58 58 0
MDM2_ENST00000539479 MDM2 Q00987 E3 ubiquitin-protein ligase Mdm2 chr12 Census, Compendium Yes 1 intact 56 297 37 37 0
MDM4 MDM4 O15151 Protein Mdm4 chr1 Census, Compendium Yes 1 intact, hippie 57 202 26 26 1
MFAP4_ENST00000299610 MFAP4 P55083 Microfibril-associated glycoprotein 4 chr17 Not Cancer Driver No 1 hippie 35 0 0 0 0
MYC_ENST00000377970 MYC P01106 Myc proto-oncogene protein chr8 Census, Compendium Yes 1 hippie 80 299 46 46 0
NAGK_ENST00000244204 NAGK Q9UJ70 N-acetyl-D-glucosamine kinase chr2 Not Cancer Driver No 1 hippie, biogrid 46 5 1 1 0
NDRG2 NDRG2 Q9UN36 Protein NDRG2 chr14 Not Cancer Driver No 1 hippie, biogrid 45 111 8 8 0
NFKBIA NFKBIA P25963 NF-kappa-B inhibitor alpha chr14 Compendium Yes 1 hippie 37 102 9 9 1
NRSN1 NRSN1 Q8IZ57 Neurensin-1 chr6 Not Cancer Driver No 1 hippie, biogrid 46 17 9 9 0
NT5C3A NT5C3A Q9H0P0 Cytosolic 5'-nucleotidase 3A chr7 Compendium Yes 1 hippie, biogrid 44 0 0 0 8
PAPSS2_ENST00000361175 PAPSS2 O95340 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 chr10 Not Cancer Driver No 1 hippie, biogrid 81 100 7 7 4
PFDN5 PFDN5 Q99471 Prefoldin subunit 5 chr12 Not Cancer Driver No 1 hippie 18 3 0 0 0
PLA2G4D PLA2G4D Q86XP0 Cytosolic phospholipase A2 delta chr15 Not Cancer Driver No 1 hippie, biogrid 115 172 17 17 0
PPL PPL O60437 Periplakin chr16 Not Cancer Driver No 1 hippie, biogrid 219 1133 133 133 0
PSEN2 PSEN2 P49810 Presenilin-2 chr1 Not Cancer Driver No 1 intact, hippie, biogrid 68 89 16 16 7
RAB7A RAB7A P51149 Ras-related protein Rab-7a chr3 Not Cancer Driver No 1 hippie 27 11 0 0 4
RAD23A RAD23A P54725 UV excision repair protein RAD23 homolog A chr19 Not Cancer Driver No 1 hippie 50 283 41 41 0
RAD51_ENST00000267868 RAD51 Q06609 DNA repair protein RAD51 homolog 1 chr15 Not Cancer Driver No 1 hippie 42 47 5 5 3
RBCK1 RBCK1 Q9BYM8 RanBP-type and C3HC4-type zinc finger-containing protein 1 chr20 Not Cancer Driver No 1 intact, hippie 52 140 14 14 2
RGS9BP RGS9BP Q6ZS82 Regulator of G-protein signaling 9-binding protein chr19 Not Cancer Driver No 1 hippie, biogrid 16 22 1 1 0
RNF115 RNF115 Q9Y4L5 E3 ubiquitin-protein ligase RNF115 chr1 Not Cancer Driver No 1 hippie 30 136 14 14 0
RPL18A RPL18A Q02543 60S ribosomal protein L18a chr19 Not Cancer Driver No 1 hippie 28 25 4 4 0
S100A7A_ENST00000329256 S100A7A Q86SG5 Protein S100-A7A chr1 Not Cancer Driver No 1 hippie, biogrid 31 20 12 12 0
SCN1B_ENST00000262631 SCN1B Q07699 Sodium channel subunit beta-1 chr19 Not Cancer Driver No 1 hippie, biogrid 35 4 1 1 5
SERPINA3_ENST00000393080 SERPINA3 P01011 Alpha-1-antichymotrypsin chr14 Not Cancer Driver No 1 hippie, biogrid 117 18 10 10 0
SERPINA9_ENST00000380365 SERPINA9 Q86WD7 Serpin A9 chr14 Not Cancer Driver No 1 hippie, biogrid 96 25 6 6 0
SERPINB13_ENST00000344731 SERPINB13 Q9UIV8 Serpin B13 chr18 Not Cancer Driver No 1 hippie, biogrid 84 55 16 16 0
SERPINB2_ENST00000299502 SERPINB2 P05120 Plasminogen activator inhibitor 2 chr18 Not Cancer Driver No 1 hippie, biogrid 100 29 7 7 0
SERPINB3 SERPINB3 P29508 Serpin B3 chr18 Not Cancer Driver No 1 hippie, biogrid 142 47 28 28 0
SERPINB4 SERPINB4 P48594 Serpin B4 chr18 Not Cancer Driver No 1 hippie, biogrid 120 48 18 18 0
SERPINB7 SERPINB7 O75635 Serpin B7 chr18 Not Cancer Driver No 1 hippie, biogrid 100 30 8 8 0
SFN SFN P31947 14-3-3 protein sigma chr1 Not Cancer Driver No 1 hippie 27 75 9 9 0
SLC10A7_ENST00000335472 SLC10A7 Q0GE19 Sodium/bile acid cotransporter 7 chr4 Not Cancer Driver No 1 hippie, biogrid 48 0 0 0 3
SLC17A2_ENST00000265425 SLC17A2 O00624 Sodium-dependent phosphate transport protein 3 chr6 Not Cancer Driver No 1 hippie, biogrid 81 12 5 5 0
STAT3 STAT3 P40763 Signal transducer and activator of transcription 3 chr17 Census, Compendium Yes 1 hippie, biogrid 110 152 15 15 19
SUFU SUFU Q9UMX1 Suppressor of fused homolog chr10 Census Yes 1 intact 55 199 19 19 2
SULT2B1 SULT2B1 O00204 Sulfotransferase 2B1 chr19 Not Cancer Driver No 1 hippie, biogrid 42 100 11 11 0
TANK TANK Q92844 TRAF family member-associated NF-kappa-B activator chr2 Not Cancer Driver No 1 intact, hippie 42 302 26 26 0
TAX1BP1 TAX1BP1 Q86VP1 Tax1-binding protein 1 chr7 Not Cancer Driver No 2 hippie, biogrid 78 429 50 50 0
TGM1 TGM1 P22735 Protein-glutamine gamma-glutamyltransferase K chr14 Not Cancer Driver No 1 hippie, biogrid 118 230 37 37 65
TMEM40_ENST00000264728 TMEM40 Q8WWA1 Transmembrane protein 40 chr3 Not Cancer Driver No 1 hippie, biogrid 27 150 23 23 0
TNIP1_ENST00000522226 TNIP1 Q15025 TNFAIP3-interacting protein 1 chr5 Not Cancer Driver No 1 intact, hippie 85 625 83 83 0
TRADD TRADD Q15628 Tumor necrosis factor receptor type 1-associated DEATH domain protein chr16 Not Cancer Driver No 1 intact, hippie 26 74 5 5 0
TTR TTR P02766 Transthyretin chr18 Not Cancer Driver No 1 hippie 28 25 8 8 75
TYMP_ENST00000395680 TYMP P19971 Thymidine phosphorylase chr22 Not Cancer Driver No 1 hippie, biogrid 28 143 7 7 5
UBA52_ENST00000595683 UBA52 P62987 Ubiquitin-60S ribosomal protein L40 chr19 Not Cancer Driver No 1 hippie 19 45 8 8 0
UBE2D1 UBE2D1 P51668 Ubiquitin-conjugating enzyme E2 D1 chr10 Not Cancer Driver No 1 hippie 13 14 0 0 0
UBE2D2 UBE2D2 P62837 Ubiquitin-conjugating enzyme E2 D2 chr5 Compendium Yes 1 hippie 19 13 1 1 0
UBE2D3_ENST00000394801 UBE2D3 P61077 Ubiquitin-conjugating enzyme E2 D3 chr4 Not Cancer Driver No 1 hippie 21 13 4 4 0
UBE2D4 UBE2D4 Q9Y2X8 Ubiquitin-conjugating enzyme E2 D4 chr7 Not Cancer Driver No 1 hippie 13 21 1 1 0
UBE2E1 UBE2E1 P51965 Ubiquitin-conjugating enzyme E2 E1 chr3 Not Cancer Driver No 1 intact, hippie 21 78 10 10 0
UBE2E2_ENST00000425792 UBE2E2 Q96LR5 Ubiquitin-conjugating enzyme E2 E2 chr3 Not Cancer Driver No 1 intact, hippie 28 90 15 15 0
UBE2E3_ENST00000602710 UBE2E3 Q969T4 Ubiquitin-conjugating enzyme E2 E3 chr2 Not Cancer Driver No 2 intact, hippie 34 97 14 14 0
UBE2I UBE2I P63279 SUMO-conjugating enzyme UBC9 chr16 Not Cancer Driver No 1 hippie 16 16 3 3 0
UBE2N UBE2N P61088 Ubiquitin-conjugating enzyme E2 N chr12 Not Cancer Driver No 1 hippie 25 24 3 3 0
UBE2W_ENST00000602593 UBE2W Q96B02 Ubiquitin-conjugating enzyme E2 W chr8 Not Cancer Driver No 2 hippie, biogrid 19 26 5 5 0
USP9X_ENST00000378308 USP9X Q93008 Probable ubiquitin carboxyl-terminal hydrolase FAF-X chrX Census, Compendium Yes 1 hippie 339 405 51 51 1
VCP VCP P55072 Transitional endoplasmic reticulum ATPase chr9 Not Cancer Driver No 2 intact, hippie 88 186 16 16 16
YWHAB_ENST00000353703 YWHAB P31946 14-3-3 protein beta/alpha chr20 Not Cancer Driver No 1 hippie 22 109 4 4 0