Identifier |
UniProt Gene |
UniProt Accession |
UniProt Name |
Chromosome |
Cancer Database |
Cancer Driver |
Number of independent pubication |
Interaction Database |
Number of missense mutations |
Number of disordered residues |
Number of mutations in disordered residues |
Number of mutations in disordered residues |
Number of omim mutations |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AARS2 | AARS2 | Q5JTZ9 | Alanine--tRNA ligase, mitochondrial | chr6 | Not Cancer Driver | No | 1 | hippie, biogrid | 123 | 203 | 25 | 25 | 5 |
| ACAD9 | ACAD9 | Q9H845 | Complex I assembly factor ACAD9, mitochondrial | chr3 | Not Cancer Driver | No | 1 | hippie, biogrid | 69 | 28 | 5 | 5 | 12 |
| AHNAK | AHNAK | Q09666 | Neuroblast differentiation-associated protein AHNAK | chr11 | Not Cancer Driver | No | 1 | hippie, biogrid | 805 | 5777 | 794 | 794 | 0 |
| AHNAK2 | AHNAK2 | Q8IVF2 | Protein AHNAK2 | chr14 | Not Cancer Driver | No | 3 | intact, hippie, biogrid | 1074 | 5470 | 1018 | 1018 | 0 |
| AIFM1 | AIFM1 | O95831 | Apoptosis-inducing factor 1, mitochondrial | chrX | Not Cancer Driver | No | 1 | intact, hippie | 88 | 166 | 22 | 22 | 11 |
| APP | APP | P05067 | Amyloid-beta precursor protein | chr21 | Not Cancer Driver | No | 1 | hippie | 128 | 418 | 71 | 71 | 17 |
| ARHGEF15 | ARHGEF15 | O94989 | Rho guanine nucleotide exchange factor 15 | chr17 | Not Cancer Driver | No | 1 | hippie, biogrid | 156 | 536 | 97 | 97 | 0 |
| AUH | AUH | Q13825 | Methylglutaconyl-CoA hydratase, mitochondrial | chr9 | Not Cancer Driver | No | 1 | hippie, biogrid | 34 | 29 | 0 | 0 | 1 |
| AURKAIP1_ENST00000321751 | AURKAIP1 | Q9NWT8 | Aurora kinase A-interacting protein | chr1 | Not Cancer Driver | No | 1 | hippie | 18 | 104 | 8 | 8 | 0 |
| AURKB_ENST00000585124 | AURKB | Q96GD4 | Aurora kinase B | chr17 | Not Cancer Driver | No | 1 | hippie, biogrid | 51 | 63 | 8 | 8 | 0 |
| BCL2L14 | BCL2L14 | Q9BZR8 | Apoptosis facilitator Bcl-2-like protein 14 | chr12 | Not Cancer Driver | No | 1 | hippie | 29 | 40 | 4 | 4 | 0 |
| BCR | BCR | P11274 | Breakpoint cluster region protein | chr22 | Census, Compendium | Yes | 1 | hippie, biogrid | 146 | 603 | 69 | 69 | 0 |
| BIRC3_ENST00000532808 | BIRC3 | Q13489 | Baculoviral IAP repeat-containing protein 3 | chr11 | Census, Compendium | Yes | 1 | hippie | 77 | 98 | 16 | 16 | 0 |
| C17orf80_ENST00000535032 | C17orf80 | Q9BSJ5 | Uncharacterized protein C17orf80 | chr17 | Not Cancer Driver | No | 1 | hippie, biogrid | 64 | 455 | 53 | 53 | 0 |
| C1QBP | C1QBP | Q07021 | Complement component 1 Q subcomponent-binding protein, mitochondrial | chr17 | Not Cancer Driver | No | 1 | hippie, biogrid | 14 | 103 | 6 | 6 | 2 |
| C8orf82 | C8orf82 | Q6P1X6 | UPF0598 protein C8orf82 | chr8 | Not Cancer Driver | No | 1 | hippie, biogrid | 11 | 11 | 0 | 0 | 0 |
| CCDC90B | CCDC90B | Q9GZT6 | Coiled-coil domain-containing protein 90B, mitochondrial | chr11 | Not Cancer Driver | No | 1 | hippie, biogrid | 31 | 76 | 6 | 6 | 0 |
| CDC16_ENST00000356221 | CDC16 | Q13042 | Cell division cycle protein 16 homolog | chr13 | Not Cancer Driver | No | 1 | hippie | 68 | 54 | 7 | 7 | 0 |
| CDC23 | CDC23 | Q9UJX2 | Cell division cycle protein 23 homolog | chr5 | Not Cancer Driver | No | 1 | intact, hippie | 57 | 45 | 6 | 6 | 0 |
| CEP162 | CEP162 | Q5TB80 | Centrosomal protein of 162 kDa | chr6 | Not Cancer Driver | No | 1 | intact, hippie | 162 | 1056 | 128 | 128 | 0 |
| CHCHD1 | CHCHD1 | Q96BP2 | Coiled-coil-helix-coiled-coil-helix domain-containing protein 1 | chr10 | Not Cancer Driver | No | 1 | hippie, biogrid | 11 | 67 | 8 | 8 | 0 |
| CHD3_ENST00000330494 | CHD3 | Q12873 | Chromodomain-helicase-DNA-binding protein 3 | chr17 | Not Cancer Driver | No | 1 | hippie | 235 | 1015 | 122 | 122 | 18 |
| CIC | CIC | Q96RK0 | Protein capicua homolog | chr19 | Census, Compendium | Yes | 1 | intact, hippie | 276 | 1550 | 266 | 266 | 0 |
| CLPP | CLPP | Q16740 | ATP-dependent Clp protease proteolytic subunit, mitochondrial | chr19 | Not Cancer Driver | No | 1 | hippie, biogrid | 22 | 83 | 9 | 9 | 3 |
| COL11A1 | COL11A1 | P12107 | Collagen alpha-1(XI) chain | chr1 | Not Cancer Driver | No | 1 | hippie, biogrid | 749 | 1436 | 617 | 617 | 8 |
| COX14_ENST00000550654 | COX14 | Q96I36 | Cytochrome c oxidase assembly protein COX14 | chr12 | Not Cancer Driver | No | 1 | intact, hippie | 4 | 7 | 0 | 0 | 1 |
| COX15 | COX15 | Q7KZN9 | Cytochrome c oxidase assembly protein COX15 homolog | chr10 | Not Cancer Driver | No | 1 | hippie, biogrid | 48 | 0 | 0 | 0 | 2 |
| COX4I1 | COX4I1 | P13073 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | chr16 | Not Cancer Driver | No | 2 | intact, hippie, biogrid | 17 | 5 | 1 | 1 | 1 |
| COX8A | COX8A | P10176 | Cytochrome c oxidase subunit 8A, mitochondrial | chr11 | Not Cancer Driver | No | 1 | hippie, biogrid | 10 | 1 | 0 | 0 | 0 |
| CRYZ_ENST00000340866 | CRYZ | Q08257 | Quinone oxidoreductase | chr1 | Not Cancer Driver | No | 1 | hippie, biogrid | 49 | 0 | 0 | 0 | 0 |
| CS | CS | O75390 | Citrate synthase, mitochondrial | chr12 | Not Cancer Driver | No | 2 | hippie, biogrid | 50 | 13 | 2 | 2 | 0 |
| CUL3 | CUL3 | Q13618 | Cullin-3 | chr2 | Census, Compendium | Yes | 1 | intact, hippie | 123 | 167 | 23 | 23 | 3 |
| DDX28 | DDX28 | Q9NUL7 | Probable ATP-dependent RNA helicase DDX28 | chr16 | Not Cancer Driver | No | 1 | hippie, biogrid | 37 | 127 | 3 | 3 | 0 |
| DDX3X_ENST00000629496 | DDX3X | O00571 | ATP-dependent RNA helicase DDX3X | chrX | Census, Compendium | Yes | 1 | hippie | 133 | 301 | 47 | 47 | 18 |
| DHX30 | DHX30 | Q7L2E3 | ATP-dependent RNA helicase DHX30 | chr3 | Not Cancer Driver | No | 1 | hippie, biogrid | 165 | 260 | 40 | 40 | 6 |
| DLD | DLD | P09622 | Dihydrolipoyl dehydrogenase, mitochondrial | chr7 | Not Cancer Driver | No | 1 | intact, hippie, biogrid | 67 | 17 | 0 | 0 | 10 |
| DLST | DLST | P36957 | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial | chr14 | Not Cancer Driver | No | 1 | intact, hippie, biogrid | 53 | 190 | 32 | 32 | 1 |
| DNAJA3 | DNAJA3 | Q96EY1 | DnaJ homolog subfamily A member 3, mitochondrial | chr16 | Not Cancer Driver | No | 1 | hippie, biogrid | 50 | 152 | 21 | 21 | 0 |
| DNAJC15 | DNAJC15 | Q9Y5T4 | DnaJ homolog subfamily C member 15 | chr13 | Not Cancer Driver | No | 1 | hippie, biogrid | 19 | 25 | 4 | 4 | 0 |
| DNAJC19 | DNAJC19 | Q96DA6 | Mitochondrial import inner membrane translocase subunit TIM14 | chr3 | Not Cancer Driver | No | 1 | hippie, biogrid | 19 | 27 | 6 | 6 | 0 |
| DNAJC28_ENST00000381947 | DNAJC28 | Q9NX36 | DnaJ homolog subfamily C member 28 | chr21 | Not Cancer Driver | No | 1 | hippie, biogrid | 55 | 139 | 11 | 11 | 0 |
| DNAJC30 | DNAJC30 | Q96LL9 | DnaJ homolog subfamily C member 30, mitochondrial | chr7 | Not Cancer Driver | No | 1 | hippie, biogrid | 25 | 83 | 7 | 7 | 3 |
| DNAJC4_ENST00000321685 | DNAJC4 | Q9NNZ3 | DnaJ homolog subfamily C member 4 | chr11 | Not Cancer Driver | No | 1 | hippie, biogrid | 19 | 180 | 13 | 13 | 0 |
| DNAJC7 | DNAJC7 | Q99615 | DnaJ homolog subfamily C member 7 | chr17 | Not Cancer Driver | No | 1 | hippie, biogrid | 41 | 102 | 9 | 9 | 0 |
| DOCK3 | DOCK3 | Q8IZD9 | Dedicator of cytokinesis protein 3 | chr3 | Not Cancer Driver | No | 1 | hippie, biogrid | 365 | 458 | 69 | 69 | 0 |
| EGFR | EGFR | P00533 | Epidermal growth factor receptor | chr7 | Census, Compendium | Yes | 1 | hippie | 444 | 223 | 35 | 35 | 1 |
| EIF4G2_ENST00000640650 | EIF4G2 | P78344 | Eukaryotic translation initiation factor 4 gamma 2 | chr11 | Not Cancer Driver | No | 1 | hippie, biogrid | 104 | 382 | 43 | 43 | 0 |
| EIF5A2 | EIF5A2 | Q9GZV4 | Eukaryotic translation initiation factor 5A-2 | chr3 | Not Cancer Driver | No | 1 | hippie | 20 | 28 | 4 | 4 | 0 |
| EP300 | EP300 | Q09472 | Histone acetyltransferase p300 | chr22 | Census, Compendium | Yes | 1 | hippie | 334 | 1790 | 196 | 196 | 1 |
| EPHA8 | EPHA8 | P29322 | Ephrin type-A receptor 8 | chr1 | Not Cancer Driver | No | 1 | intact | 197 | 121 | 17 | 17 | 0 |
| ESR2 | ESR2 | Q92731 | Estrogen receptor beta | chr14 | Not Cancer Driver | No | 1 | hippie | 90 | 92 | 11 | 11 | 1 |
| EXD2 | EXD2 | Q9NVH0 | Exonuclease 3'-5' domain-containing protein 2 | chr14 | Not Cancer Driver | No | 1 | hippie, biogrid | 58 | 176 | 15 | 15 | 0 |
| FAM160A2_ENST00000449352 | FHIP1B | Q8N612 | FHF complex subunit HOOK interacting protein 1B | chr11 | Not Cancer Driver | No | 1 | intact | 129 | 415 | 54 | 54 | 0 |
| FAM160B2 | FHIP2B | Q86V87 | FHF complex subunit HOOK interacting protein 2B | chr8 | Not Cancer Driver | No | 1 | intact | 75 | 139 | 14 | 14 | 0 |
| FASTKD2_ENST00000402774 | FASTKD2 | Q9NYY8 | FAST kinase domain-containing protein 2, mitochondrial | chr2 | Not Cancer Driver | No | 1 | hippie, biogrid | 74 | 30 | 2 | 2 | 0 |
| FASTKD3 | FASTKD3 | Q14CZ7 | FAST kinase domain-containing protein 3, mitochondrial | chr5 | Not Cancer Driver | No | 2 | intact, hippie, biogrid | 106 | 6 | 1 | 1 | 0 |
| FASTKD5 | FASTKD5 | Q7L8L6 | FAST kinase domain-containing protein 5, mitochondrial | chr20 | Not Cancer Driver | No | 1 | hippie, biogrid | 86 | 94 | 8 | 8 | 0 |
| FBXW7_ENST00000603841 | FBXW7 | Q969H0 | F-box/WD repeat-containing protein 7 | chr4 | Census, Compendium | Yes | 1 | hippie | 322 | 230 | 38 | 38 | 0 |
| FGFR3_ENST00000440486 | FGFR3 | P22607 | Fibroblast growth factor receptor 3 | chr4 | Census, Compendium | Yes | 1 | intact | 173 | 241 | 26 | 26 | 37 |
| FKBPL | FKBPL | Q9UIM3 | FK506-binding protein-like | chr6 | Not Cancer Driver | No | 1 | hippie | 48 | 202 | 28 | 28 | 0 |
| FXR1 | FXR1 | P51114 | Fragile X mental retardation syndrome-related protein 1 | chr3 | Not Cancer Driver | No | 1 | intact, hippie | 88 | 312 | 53 | 53 | 0 |
| FXR2 | FXR2 | P51116 | Fragile X mental retardation syndrome-related protein 2 | chr17 | Not Cancer Driver | No | 1 | intact, hippie | 68 | 388 | 42 | 42 | 0 |
| G3BP1 | G3BP1 | Q13283 | Ras GTPase-activating protein-binding protein 1 | chr5 | Not Cancer Driver | No | 1 | intact | 85 | 352 | 65 | 65 | 0 |
| GFM1_ENST00000486715 | GFM1 | Q96RP9 | Elongation factor G, mitochondrial | chr3 | Not Cancer Driver | No | 1 | hippie, biogrid | 74 | 79 | 7 | 7 | 4 |
| GFM2_ENST00000509430 | GFM2 | Q969S9 | Ribosome-releasing factor 2, mitochondrial | chr5 | Not Cancer Driver | No | 1 | hippie, biogrid | 75 | 100 | 10 | 10 | 2 |
| GRSF1 | GRSF1 | Q12849 | G-rich sequence factor 1 | chr4 | Not Cancer Driver | No | 2 | hippie, biogrid | 49 | 147 | 20 | 20 | 0 |
| HINT2 | HINT2 | Q9BX68 | Adenosine 5'-monophosphoramidase HINT2 | chr9 | Not Cancer Driver | No | 1 | hippie, biogrid | 10 | 29 | 2 | 2 | 0 |
| HSCB | HSCB | Q8IWL3 | Iron-sulfur cluster co-chaperone protein HscB | chr22 | Not Cancer Driver | No | 2 | intact, hippie, biogrid | 36 | 25 | 6 | 6 | 0 |
| HSPA1A | HSPA1A | P0DMV8 | Heat shock 70 kDa protein 1A | chr6 | Not Cancer Driver | No | 1 | hippie, biogrid | 24 | 200 | 13 | 13 | 0 |
| HSPA4 | HSPA4 | P34932 | Heat shock 70 kDa protein 4 | chr5 | Not Cancer Driver | No | 1 | hippie, biogrid | 80 | 351 | 24 | 24 | 0 |
| HSPA9 | HSPA9 | P38646 | Stress-70 protein, mitochondrial | chr5 | Not Cancer Driver | No | 1 | hippie, biogrid | 67 | 283 | 26 | 26 | 2 |
| HSPD1 | HSPD1 | P10809 | 60 kDa heat shock protein, mitochondrial | chr2 | Not Cancer Driver | No | 1 | intact, hippie | 61 | 82 | 6 | 6 | 2 |
| HTRA2 | HTRA2 | O43464 | Serine protease HTRA2, mitochondrial | chr2 | Compendium | Yes | 1 | hippie | 44 | 127 | 9 | 9 | 2 |
| IMMP1L | IMMP1L | Q96LU5 | Mitochondrial inner membrane protease subunit 1 | chr11 | Not Cancer Driver | No | 1 | hippie | 20 | 3 | 0 | 0 | 0 |
| IMMP2L_ENST00000452895 | IMMP2L | Q96T52 | Mitochondrial inner membrane protease subunit 2 | chr7 | Not Cancer Driver | No | 1 | hippie | 36 | 29 | 7 | 7 | 0 |
| IRF2 | IRF2 | P14316 | Interferon regulatory factor 2 | chr4 | Not Cancer Driver | No | 1 | intact, hippie | 85 | 288 | 73 | 73 | 0 |
| KCND3 | KCND3 | Q9UK17 | Potassium voltage-gated channel subfamily D member 3 | chr1 | Not Cancer Driver | No | 1 | hippie | 172 | 202 | 44 | 44 | 5 |
| KIF23 | KIF23 | Q02241 | Kinesin-like protein KIF23 | chr15 | Not Cancer Driver | No | 1 | hippie | 102 | 559 | 62 | 62 | 0 |
| L1TD1 | L1TD1 | Q5T7N2 | LINE-1 type transposase domain-containing protein 1 | chr1 | Not Cancer Driver | No | 1 | intact, hippie | 149 | 534 | 114 | 114 | 0 |
| LMTK2 | LMTK2 | Q8IWU2 | Serine/threonine-protein kinase LMTK2 | chr7 | Not Cancer Driver | No | 1 | intact | 211 | 1018 | 141 | 141 | 0 |
| LONP1 | LONP1 | P36776 | Lon protease homolog, mitochondrial | chr19 | Not Cancer Driver | No | 1 | hippie, biogrid | 99 | 175 | 15 | 15 | 10 |
| LRPPRC | LRPPRC | P42704 | Leucine-rich PPR motif-containing protein, mitochondrial | chr2 | Not Cancer Driver | No | 1 | hippie, biogrid | 131 | 18 | 2 | 2 | 1 |
| LRRK2 | LRRK2 | Q5S007 | Leucine-rich repeat serine/threonine-protein kinase 2 | chr12 | Not Cancer Driver | No | 1 | intact | 519 | 90 | 17 | 17 | 23 |
| MCC_ENST00000302475 | MCC | P23508 | Colorectal mutant cancer protein | chr5 | Not Cancer Driver | No | 1 | intact, hippie | 136 | 589 | 92 | 92 | 0 |
| MCU | MCU | Q8NE86 | Calcium uniporter protein, mitochondrial | chr10 | Not Cancer Driver | No | 1 | hippie, biogrid | 41 | 13 | 0 | 0 | 0 |
| MCUB | MCUB | Q9NWR8 | Calcium uniporter regulatory subunit MCUb, mitochondrial | chr4 | Not Cancer Driver | No | 1 | hippie | 33 | 24 | 1 | 1 | 0 |
| MCUR1 | MCUR1 | Q96AQ8 | Mitochondrial calcium uniporter regulator 1 | chr6 | Not Cancer Driver | No | 1 | hippie, biogrid | 30 | 65 | 0 | 0 | 0 |
| MDC1 | MDC1 | Q14676 | Mediator of DNA damage checkpoint protein 1 | chr6 | Not Cancer Driver | No | 1 | hippie | 249 | 1829 | 223 | 223 | 0 |
| MDH2 | MDH2 | P40926 | Malate dehydrogenase, mitochondrial | chr7 | Not Cancer Driver | No | 1 | hippie, biogrid | 39 | 8 | 1 | 1 | 3 |
| MDM2_ENST00000539479 | MDM2 | Q00987 | E3 ubiquitin-protein ligase Mdm2 | chr12 | Census, Compendium | Yes | 1 | hippie | 56 | 297 | 37 | 37 | 0 |
| ME2 | ME2 | P23368 | NAD-dependent malic enzyme, mitochondrial | chr18 | Not Cancer Driver | No | 1 | hippie, biogrid | 69 | 32 | 5 | 5 | 0 |
| METTL15 | METTL15 | A6NJ78 | 12S rRNA N4-methylcytidine (m4C) methyltransferase | chr11 | Not Cancer Driver | No | 1 | hippie, biogrid | 46 | 92 | 14 | 14 | 0 |
| METTL17_ENST00000339374 | METTL17 | Q9H7H0 | Methyltransferase-like protein 17, mitochondrial | chr14 | Not Cancer Driver | No | 1 | hippie, biogrid | 62 | 95 | 16 | 16 | 0 |
| MFSD4A | MFSD4A | Q8N468 | Major facilitator superfamily domain-containing protein 4A | chr1 | Not Cancer Driver | No | 1 | hippie | 56 | 29 | 3 | 3 | 0 |
| MGST3 | MGST3 | O14880 | Microsomal glutathione S-transferase 3 | chr1 | Not Cancer Driver | No | 1 | intact, hippie | 17 | 0 | 0 | 0 | 0 |
| MRPL11 | MRPL11 | Q9Y3B7 | 39S ribosomal protein L11, mitochondrial | chr11 | Not Cancer Driver | No | 1 | hippie, biogrid | 25 | 12 | 1 | 1 | 0 |
| MRPL58 | MRPL58 | Q14197 | Peptidyl-tRNA hydrolase ICT1, mitochondrial | chr17 | Not Cancer Driver | No | 1 | hippie | 28 | 105 | 13 | 13 | 0 |
| MRPS12_ENST00000402029 | MRPS12 | O15235 | 28S ribosomal protein S12, mitochondrial | chr19 | Not Cancer Driver | No | 1 | hippie, biogrid | 18 | 59 | 11 | 11 | 0 |
| MRPS26 | MRPS26 | Q9BYN8 | 28S ribosomal protein S26, mitochondrial | chr20 | Not Cancer Driver | No | 1 | hippie, biogrid | 18 | 102 | 6 | 6 | 0 |
| MRRF | MRRF | Q96E11 | Ribosome-recycling factor, mitochondrial | chr9 | Not Cancer Driver | No | 1 | hippie, biogrid | 23 | 118 | 9 | 9 | 0 |
| MTERF3 | MTERF3 | Q96E29 | Transcription termination factor 3, mitochondrial | chr8 | Not Cancer Driver | No | 1 | hippie, biogrid | 53 | 62 | 5 | 5 | 0 |
| MTFMT | MTFMT | Q96DP5 | Methionyl-tRNA formyltransferase, mitochondrial | chr15 | Not Cancer Driver | No | 1 | hippie, biogrid | 35 | 56 | 3 | 3 | 3 |
| MTG2 | MTG2 | Q9H4K7 | Mitochondrial ribosome-associated GTPase 2 | chr20 | Not Cancer Driver | No | 1 | hippie, biogrid | 57 | 47 | 9 | 9 | 0 |
| MTIF2_ENST00000403721 | MTIF2 | P46199 | Translation initiation factor IF-2, mitochondrial | chr2 | Not Cancer Driver | No | 1 | hippie, biogrid | 101 | 112 | 9 | 9 | 0 |
| MTIF3_ENST00000381120 | MTIF3 | Q9H2K0 | Translation initiation factor IF-3, mitochondrial | chr13 | Not Cancer Driver | No | 1 | hippie, biogrid | 26 | 180 | 19 | 19 | 0 |
| MTRF1 | MTRF1 | O75570 | Peptide chain release factor 1, mitochondrial | chr13 | Not Cancer Driver | No | 1 | hippie, biogrid | 50 | 71 | 9 | 9 | 0 |
| MTRF1L | MTRF1L | Q9UGC7 | Peptide chain release factor 1-like, mitochondrial | chr6 | Not Cancer Driver | No | 1 | hippie, biogrid | 31 | 183 | 12 | 12 | 0 |
| MYC_ENST00000377970 | MYC | P01106 | Myc proto-oncogene protein | chr8 | Census, Compendium | Yes | 1 | hippie | 80 | 299 | 46 | 46 | 0 |
| MYO18A | MYO18A | Q92614 | Unconventional myosin-XVIIIa | chr17 | Not Cancer Driver | No | 3 | intact, hippie, biogrid | 268 | 1237 | 176 | 176 | 0 |
| MYO1F | MYO1F | O00160 | Unconventional myosin-If | chr19 | Not Cancer Driver | No | 2 | hippie, biogrid | 209 | 246 | 48 | 48 | 0 |
| NF2 | NF2 | P35240 | Merlin | chr22 | Census, Compendium | Yes | 1 | hippie | 69 | 252 | 26 | 26 | 16 |
| NGRN | NGRN | Q9NPE2 | Neugrin | chr15 | Not Cancer Driver | No | 1 | hippie, biogrid | 26 | 215 | 21 | 21 | 0 |
| NMRAL1 | NMRAL1 | Q9HBL8 | NmrA-like family domain-containing protein 1 | chr16 | Not Cancer Driver | No | 1 | hippie | 39 | 14 | 3 | 3 | 0 |
| NPLOC4 | NPLOC4 | Q8TAT6 | Nuclear protein localization protein 4 homolog | chr17 | Not Cancer Driver | No | 1 | hippie | 78 | 47 | 8 | 8 | 0 |
| NR3C1_ENST00000343796 | NR3C1 | P04150 | Glucocorticoid receptor | chr5 | Not Cancer Driver | No | 1 | hippie | 92 | 362 | 37 | 37 | 12 |
| NT5C3A | NT5C3A | Q9H0P0 | Cytosolic 5'-nucleotidase 3A | chr7 | Compendium | Yes | 1 | intact, hippie | 44 | 0 | 0 | 0 | 8 |
| NTRK1 | NTRK1 | P04629 | High affinity nerve growth factor receptor | chr1 | Census, Compendium | Yes | 1 | hippie | 168 | 57 | 8 | 8 | 25 |
| NUDT5_ENST00000537776 | NUDT5 | Q9UKK9 | ADP-sugar pyrophosphatase | chr10 | Not Cancer Driver | No | 3 | hippie, biogrid | 27 | 90 | 11 | 11 | 0 |
| OTC | OTC | P00480 | Ornithine transcarbamylase, mitochondrial | chrX | Not Cancer Driver | No | 1 | hippie, biogrid | 89 | 24 | 4 | 4 | 111 |
| PAICS_ENST00000512576 | PAICS | P22234 | Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase | chr4 | Not Cancer Driver | No | 1 | hippie, biogrid | 23 | 35 | 3 | 3 | 0 |
| PARL | PARL | Q9H300 | Presenilins-associated rhomboid-like protein, mitochondrial | chr3 | Not Cancer Driver | No | 1 | intact, hippie | 49 | 28 | 5 | 5 | 0 |
| PCCB_ENST00000251654 | PCCB | P05166 | Propionyl-CoA carboxylase beta chain, mitochondrial | chr3 | Not Cancer Driver | No | 1 | hippie, biogrid | 59 | 64 | 12 | 12 | 25 |
| PDHA1_ENST00000422285 | PDHA1 | P08559 | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | chrX | Not Cancer Driver | No | 2 | hippie, biogrid | 70 | 43 | 6 | 6 | 20 |
| PDK1_ENST00000282077 | PDK1 | Q15118 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial | chr2 | Not Cancer Driver | No | 2 | intact, hippie | 52 | 50 | 10 | 10 | 0 |
| PDK4 | PDK4 | Q16654 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | chr7 | Not Cancer Driver | No | 1 | intact, hippie, biogrid | 70 | 14 | 2 | 2 | 0 |
| PLEKHA4 | PLEKHA4 | Q9H4M7 | Pleckstrin homology domain-containing family A member 4 | chr19 | Not Cancer Driver | No | 1 | hippie | 136 | 687 | 128 | 128 | 0 |
| PMPCA | PMPCA | Q10713 | Mitochondrial-processing peptidase subunit alpha | chr9 | Not Cancer Driver | No | 1 | hippie, biogrid | 67 | 23 | 3 | 3 | 4 |
| PMPCB | PMPCB | O75439 | Mitochondrial-processing peptidase subunit beta | chr7 | Not Cancer Driver | No | 1 | hippie, biogrid | 55 | 22 | 3 | 3 | 5 |
| PRDX4 | PRDX4 | Q13162 | Peroxiredoxin-4 | chrX | Not Cancer Driver | No | 1 | hippie, biogrid | 36 | 29 | 2 | 2 | 0 |
| PTPN11_ENST00000351677 | PTPN11 | Q06124 | Tyrosine-protein phosphatase non-receptor type 11 | chr12 | Census, Compendium | Yes | 1 | intact | 129 | 260 | 38 | 38 | 60 |
| PYCR1_ENST00000329875 | PYCR1 | P32322 | Pyrroline-5-carboxylate reductase 1, mitochondrial | chr17 | Not Cancer Driver | No | 3 | intact, hippie, biogrid | 31 | 67 | 10 | 10 | 9 |
| PYCR3_ENST00000495276 | PYCR3 | Q53H96 | Pyrroline-5-carboxylate reductase 3 | chr8 | Not Cancer Driver | No | 2 | intact, hippie | 21 | 11 | 0 | 0 | 0 |
| RAC1_ENST00000348035 | RAC1 | P63000 | Ras-related C3 botulinum toxin substrate 1 | chr7 | Census, Compendium | Yes | 1 | intact, hippie | 66 | 2 | 1 | 1 | 6 |
| RAMP3 | RAMP3 | O60896 | Receptor activity-modifying protein 3 | chr7 | Not Cancer Driver | No | 1 | hippie, biogrid | 30 | 0 | 0 | 0 | 0 |
| RBM11 | RBM11 | P57052 | Splicing regulator RBM11 | chr21 | Not Cancer Driver | No | 1 | hippie, biogrid | 67 | 124 | 38 | 38 | 0 |
| RC3H1_ENST00000258349 | RC3H1 | Q5TC82 | Roquin-1 | chr1 | Not Cancer Driver | No | 1 | hippie | 158 | 796 | 115 | 115 | 0 |
| RC3H2_ENST00000357244 | RC3H2 | Q9HBD1 | Roquin-2 | chr9 | Not Cancer Driver | No | 1 | hippie | 128 | 703 | 81 | 81 | 0 |
| RECQL4 | RECQL4 | O94761 | ATP-dependent DNA helicase Q4 | chr8 | Census, Compendium | Yes | 1 | hippie | 138 | 608 | 71 | 71 | 1 |
| RELA | RELA | Q04206 | Transcription factor p65 | chr11 | Compendium | Yes | 1 | intact, hippie | 75 | 400 | 48 | 48 | 0 |
| RHOG_ENST00000396978 | RHOG | P84095 | Rho-related GTP-binding protein RhoG | chr11 | Not Cancer Driver | No | 1 | hippie | 26 | 22 | 5 | 5 | 0 |
| RMND1 | RMND1 | Q9NWS8 | Required for meiotic nuclear division protein 1 homolog | chr6 | Not Cancer Driver | No | 1 | hippie, biogrid | 46 | 83 | 11 | 11 | 1 |
| RPUSD3 | RPUSD3 | Q6P087 | Mitochondrial mRNA pseudouridine synthase RPUSD3 | chr3 | Not Cancer Driver | No | 1 | hippie, biogrid | 33 | 85 | 5 | 5 | 0 |
| RPUSD4 | RPUSD4 | Q96CM3 | Pseudouridylate synthase RPUSD4, mitochondrial | chr11 | Not Cancer Driver | No | 1 | hippie, biogrid | 54 | 97 | 15 | 15 | 0 |
| SCO1 | SCO1 | O75880 | Protein SCO1 homolog, mitochondrial | chr17 | Not Cancer Driver | No | 1 | intact, hippie | 35 | 79 | 7 | 7 | 1 |
| SFXN1 | SFXN1 | Q9H9B4 | Sideroflexin-1 | chr5 | Not Cancer Driver | No | 1 | intact, hippie | 31 | 29 | 1 | 1 | 0 |
| SH2D3C | SH2D3C | Q8N5H7 | SH2 domain-containing protein 3C | chr9 | Not Cancer Driver | No | 1 | intact, hippie | 110 | 440 | 72 | 72 | 0 |
| SHC1_ENST00000368445 | SHC1 | P29353 | SHC-transforming protein 1 | chr1 | Not Cancer Driver | No | 1 | intact, hippie | 84 | 397 | 58 | 58 | 0 |
| SIRT4 | SIRT4 | Q9Y6E7 | NAD-dependent protein lipoamidase sirtuin-4, mitochondrial | chr12 | Not Cancer Driver | No | 1 | hippie | 46 | 4 | 0 | 0 | 0 |
| SKA1_ENST00000398452 | SKA1 | Q96BD8 | Spindle and kinetochore-associated protein 1 | chr18 | Not Cancer Driver | No | 3 | intact, hippie, biogrid | 23 | 74 | 7 | 7 | 0 |
| SKA3 | SKA3 | Q8IX90 | Spindle and kinetochore-associated protein 3 | chr13 | Not Cancer Driver | No | 3 | intact, hippie, biogrid | 56 | 230 | 32 | 32 | 0 |
| SKIL_ENST00000259119 | SKIL | P12757 | Ski-like protein | chr3 | Not Cancer Driver | No | 1 | intact, hippie | 77 | 356 | 32 | 32 | 0 |
| SLIRP | SLIRP | Q9GZT3 | SRA stem-loop-interacting RNA-binding protein, mitochondrial | chr14 | Not Cancer Driver | No | 1 | hippie, biogrid | 7 | 41 | 3 | 3 | 0 |
| SSBP1_ENST00000484178 | SSBP1 | Q04837 | Single-stranded DNA-binding protein, mitochondrial | chr7 | Not Cancer Driver | No | 1 | hippie, biogrid | 27 | 0 | 0 | 0 | 6 |
| SUMO2 | SUMO2 | P61956 | Small ubiquitin-related modifier 2 | chr17 | Not Cancer Driver | No | 1 | hippie | 9 | 69 | 6 | 6 | 0 |
| SURF1 | SURF1 | Q15526 | Surfeit locus protein 1 | chr9 | Not Cancer Driver | No | 1 | hippie, biogrid | 17 | 82 | 6 | 6 | 11 |
| SYDE1 | SYDE1 | Q6ZW31 | Rho GTPase-activating protein SYDE1 | chr19 | Not Cancer Driver | No | 1 | hippie, biogrid | 62 | 412 | 27 | 27 | 0 |
| TACO1 | TACO1 | Q9BSH4 | Translational activator of cytochrome c oxidase 1 | chr17 | Not Cancer Driver | No | 1 | hippie, biogrid | 21 | 111 | 2 | 2 | 0 |
| TBRG4_ENST00000494076 | TBRG4 | Q969Z0 | FAST kinase domain-containing protein 4 | chr7 | Not Cancer Driver | No | 1 | hippie, biogrid | 74 | 60 | 2 | 2 | 0 |
| TEFM | TEFM | Q96QE5 | Transcription elongation factor, mitochondrial | chr17 | Not Cancer Driver | No | 1 | hippie, biogrid | 37 | 26 | 5 | 5 | 0 |
| TERF2 | TERF2 | Q15554 | Telomeric repeat-binding factor 2 | chr16 | Not Cancer Driver | No | 1 | hippie | 33 | 361 | 20 | 20 | 0 |
| TFAM | TFAM | Q00059 | Transcription factor A, mitochondrial | chr10 | Not Cancer Driver | No | 1 | hippie, biogrid | 25 | 110 | 15 | 15 | 1 |
| TIAF1 | MYO18A | O95411 | Putative TGFB1-induced anti-apoptotic factor 1 | chr17 | Not Cancer Driver | No | 3 | intact, hippie, biogrid | 16 | 30 | 5 | 5 | 0 |
| TMEM70 | TMEM70 | Q9BUB7 | Transmembrane protein 70, mitochondrial | chr8 | Not Cancer Driver | No | 1 | hippie, biogrid | 26 | 24 | 4 | 4 | 1 |
| TNFRSF10A | TNFRSF10A | O00220 | Tumor necrosis factor receptor superfamily member 10A | chr8 | Not Cancer Driver | No | 1 | hippie | 55 | 174 | 17 | 17 | 0 |
| TNIP2 | TNIP2 | Q8NFZ5 | TNFAIP3-interacting protein 2 | chr4 | Not Cancer Driver | No | 1 | hippie | 43 | 316 | 36 | 36 | 0 |
| TNS3 | TNS3 | Q68CZ2 | Tensin-3 | chr7 | Not Cancer Driver | No | 1 | intact, hippie | 238 | 864 | 143 | 143 | 0 |
| TRAP1 | TRAP1 | Q12931 | Heat shock protein 75 kDa, mitochondrial | chr16 | Not Cancer Driver | No | 1 | hippie, biogrid | 74 | 110 | 11 | 11 | 0 |
| TRIM14 | TRIM14 | Q14142 | Tripartite motif-containing protein 14 | chr9 | Not Cancer Driver | No | 1 | hippie | 36 | 93 | 7 | 7 | 0 |
| TRIM28 | TRIM28 | Q13263 | Transcription intermediary factor 1-beta | chr19 | Not Cancer Driver | No | 1 | hippie | 87 | 430 | 41 | 41 | 0 |
| TRMT61B | TRMT61B | Q9BVS5 | tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial | chr2 | Not Cancer Driver | No | 1 | intact, hippie | 48 | 123 | 10 | 10 | 0 |
| TRUB2 | TRUB2 | O95900 | Pseudouridylate synthase TRUB2, mitochondrial | chr9 | Not Cancer Driver | No | 1 | hippie, biogrid | 37 | 73 | 7 | 7 | 0 |
| TSFM_ENST00000454289 | TSFM | P43897 | Elongation factor Ts, mitochondrial | chr12 | Not Cancer Driver | No | 1 | hippie, biogrid | 37 | 74 | 7 | 7 | 2 |
| TUFM | TUFM | P49411 | Elongation factor Tu, mitochondrial | chr16 | Not Cancer Driver | No | 1 | hippie, biogrid | 51 | 50 | 3 | 3 | 1 |
| VCAM1 | VCAM1 | P19320 | Vascular cell adhesion protein 1 | chr1 | Not Cancer Driver | No | 1 | intact, hippie | 188 | 110 | 28 | 28 | 0 |
| VWA8 | VWA8 | A3KMH1 | von Willebrand factor A domain-containing protein 8 | chr13 | Not Cancer Driver | No | 1 | hippie, biogrid | 246 | 384 | 36 | 36 | 0 |
| ZC3H18_ENST00000301011 | ZC3H18 | Q86VM9 | Zinc finger CCCH domain-containing protein 18 | chr16 | Not Cancer Driver | No | 1 | hippie | 139 | 929 | 134 | 134 | 0 |
Identifier |
UniProt Gene |
UniProt Accession |
UniProt Name |
Chromosome |
Cancer Database |
Cancer Driver |
Number of independent pubication |
Interaction Database |
Number of missense mutations |
Number of disordered residues |
Number of mutations in disordered residues |
Number of mutations in disordered residues |
Number of omim mutations |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|