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PTPN22 ,PTPN22 ,Q9Y2R2
  • Uniprot Accession= Q9Y2R2
  • Ensembl Transcript= ENST00000359785.9
  • Uniprot Name= PTPN22
  • Name= Tyrosine-protein phosphatase non-receptor type 22
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 14
  • Number of Interaction partner in biogrid: 3
  • Number of Interaction partner in hippie: 59
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ACAD8 ACAD8 Q9UKU7 Isobutyryl-CoA dehydrogenase, mitochondrial chr11 Not Cancer Driver No 1 hippie 55 13 1 1 9
ACTA1 ACTA1 P68133 Actin, alpha skeletal muscle chr1 Not Cancer Driver No 1 hippie 70 48 14 14 84
AKR7A2 AKR7A2 O43488 Aflatoxin B1 aldehyde reductase member 2 chr1 Not Cancer Driver No 1 hippie 35 90 3 3 0
CALR CALR P27797 Calreticulin chr19 Census Yes 1 hippie 45 245 31 31 0
CALU_ENST00000249364 CALU O43852 Calumenin chr7 Not Cancer Driver No 1 hippie 34 130 12 12 0
CBL CBL P22681 E3 ubiquitin-protein ligase CBL chr11 Census, Compendium Yes 1 hippie 115 512 56 56 4
CCDC138 CCDC138 Q96M89 Coiled-coil domain-containing protein 138 chr2 Not Cancer Driver No 1 hippie 76 202 25 25 0
CD247 CD247 P20963 T-cell surface glycoprotein CD3 zeta chain chr1 Not Cancer Driver No 1 hippie 33 91 24 24 0
CD3E CD3E P07766 T-cell surface glycoprotein CD3 epsilon chain chr11 Not Cancer Driver No 1 intact, hippie 28 72 12 12 0
CDH2 CDH2 P19022 Cadherin-2 chr18 Not Cancer Driver No 1 intact, hippie 238 461 130 130 7
CEP131 CEP131 Q9UPN4 Centrosomal protein of 131 kDa chr17 Not Cancer Driver No 1 hippie 126 948 113 113 0
CLK1_ENST00000321356 CLK1 P49759 Dual specificity protein kinase CLK1 chr2 Not Cancer Driver No 1 hippie 64 131 21 21 0
CRYGD CRYGD P07320 Gamma-crystallin D chr2 Not Cancer Driver No 1 hippie, biogrid 28 0 0 0 6
CSK_ENST00000439220 CSK P41240 Tyrosine-protein kinase CSK chr15 Not Cancer Driver No 1 hippie 41 18 1 1 0
EGFR EGFR P00533 Epidermal growth factor receptor chr7 Census, Compendium Yes 1 hippie 444 223 35 35 1
EIF3E EIF3E P60228 Eukaryotic translation initiation factor 3 subunit E chr8 Census, Compendium Yes 1 hippie 73 27 1 1 0
ERBB2 ERBB2 P04626 Receptor tyrosine-protein kinase erbB-2 chr17 Census, Compendium Yes 1 hippie 275 314 41 41 1
GHR_ENST00000612382 GHR P10912 Growth hormone receptor chr5 Not Cancer Driver No 1 hippie 173 229 66 66 19
GLUD1 GLUD1 P00367 Glutamate dehydrogenase 1, mitochondrial chr10 Not Cancer Driver No 1 hippie 50 107 14 14 13
GRB2_ENST00000392564 GRB2 P62993 Growth factor receptor-bound protein 2 chr17 Not Cancer Driver No 1 intact, hippie 28 10 1 1 0
HAX1 HAX1 O00165 HCLS1-associated protein X-1 chr1 Not Cancer Driver No 1 hippie 44 219 32 32 2
HSPB1 HSPB1 P04792 Heat shock protein beta-1 chr7 Not Cancer Driver No 1 hippie 10 118 8 8 20
KIAA0753 KIAA0753 Q2KHM9 Protein moonraker chr17 Not Cancer Driver No 1 hippie 109 647 82 82 0
KIF7 KIF7 Q2M1P5 Kinesin-like protein KIF7 chr15 Not Cancer Driver No 1 hippie 150 844 104 104 5
LCK LCK P06239 Tyrosine-protein kinase Lck chr1 Census Yes 1 hippie 86 94 13 13 1
LZTS2 LZTS2 Q9BRK4 Leucine zipper putative tumor suppressor 2 chr10 Not Cancer Driver No 1 hippie 78 508 66 66 0
MAD2L1BP_ENST00000372171 MAD2L1BP Q15013 MAD2L1-binding protein chr6 Not Cancer Driver No 1 hippie 26 55 7 7 0
MAIP1 MAIP1 Q8WWC4 m-AAA protease-interacting protein 1, mitochondrial chr2 Not Cancer Driver No 1 hippie 28 12 0 0 0
MED4 MED4 Q9NPJ6 Mediator of RNA polymerase II transcription subunit 4 chr13 Not Cancer Driver No 1 hippie 29 161 17 17 0
MIB1 MIB1 Q86YT6 E3 ubiquitin-protein ligase MIB1 chr18 Not Cancer Driver No 1 hippie 122 282 34 34 1
NDUFA9 NDUFA9 Q16795 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial chr12 Not Cancer Driver No 1 hippie 57 8 0 0 2
NDUFB10 NDUFB10 O96000 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 chr16 Not Cancer Driver No 1 hippie 19 33 1 1 1
NEDD8-MDP1 NEDD8-MDP1 E9PL57 NEDD8-MDP1 readthrough (Fragment) chr14 Not Cancer Driver No 1 biogrid 28 55 13 13 0
NTRK1 NTRK1 P04629 High affinity nerve growth factor receptor chr1 Census, Compendium Yes 1 intact, hippie 168 57 8 8 25
PDGFRB PDGFRB P09619 Platelet-derived growth factor receptor beta chr5 Census, Compendium Yes 1 hippie 164 231 44 44 7
PDPK1 PDPK1 O15530 3-phosphoinositide-dependent protein kinase 1 chr16 Not Cancer Driver No 1 intact, hippie 33 121 12 12 0
PIBF1 PIBF1 Q8WXW3 Progesterone-induced-blocking factor 1 chr13 Not Cancer Driver No 1 hippie 83 419 45 45 2
PRKAR2A PRKAR2A P13861 cAMP-dependent protein kinase type II-alpha regulatory subunit chr3 Not Cancer Driver No 1 hippie 37 149 13 13 0
PRKAR2B PRKAR2B P31323 cAMP-dependent protein kinase type II-beta regulatory subunit chr7 Not Cancer Driver No 1 hippie, biogrid 60 125 4 4 0
PRKCD_ENST00000330452 PRKCD Q05655 Protein kinase C delta type chr3 Compendium Yes 1 hippie 79 43 9 9 0
PSTPIP1 PSTPIP1 O43586 Proline-serine-threonine phosphatase-interacting protein 1 chr15 Not Cancer Driver No 1 hippie 46 225 26 26 3
PSTPIP2 PSTPIP2 Q9H939 Proline-serine-threonine phosphatase-interacting protein 2 chr18 Not Cancer Driver No 1 hippie 50 89 22 22 0
PTPN22 PTPN22 Q9Y2R2 Tyrosine-protein phosphatase non-receptor type 22 chr1 Not Cancer Driver No 1 intact, hippie 141 364 62 62 4
RCN1 RCN1 Q15293 Reticulocalbin-1 chr11 Not Cancer Driver No 1 hippie 35 158 19 19 0
RPS19BP1 RPS19BP1 Q86WX3 Active regulator of SIRT1 chr22 Not Cancer Driver No 1 hippie 5 112 5 5 0
SCO2_ENST00000395693 SCO2 O43819 Protein SCO2 homolog, mitochondrial chr22 Not Cancer Driver No 1 hippie 31 51 8 8 8
SDF4 SDF4 Q9BRK5 45 kDa calcium-binding protein chr1 Not Cancer Driver No 1 hippie 48 187 30 30 0
SFXN4 SFXN4 Q6P4A7 Sideroflexin-4 chr10 Not Cancer Driver No 1 hippie 41 25 2 2 0
SKAP2 SKAP2 O75563 Src kinase-associated phosphoprotein 2 chr7 Not Cancer Driver No 1 intact, hippie 51 157 19 19 0
SLC25A19_ENST00000416858 SLC25A19 Q9HC21 Mitochondrial thiamine pyrophosphate carrier chr17 Not Cancer Driver No 1 hippie 34 16 0 0 2
SPTA1_ENST00000368147 SPTA1 P02549 Spectrin alpha chain, erythrocytic 1 chr1 Not Cancer Driver No 1 hippie 1046 707 294 294 21
SRPK2_ENST00000489828 SRPK2 P78362 SRSF protein kinase 2 chr7 Not Cancer Driver No 1 hippie 78 343 46 46 0
SSX2IP SSX2IP Q9Y2D8 Afadin- and alpha-actinin-binding protein chr1 Not Cancer Driver No 1 hippie 82 265 31 31 0
TBC1D31 TBC1D31 Q96DN5 TBC1 domain family member 31 chr8 Not Cancer Driver No 1 hippie 134 308 37 37 0
TRAF3_ENST00000392745 TRAF3 Q13114 TNF receptor-associated factor 3 chr14 Compendium Yes 1 intact, hippie 61 101 9 9 1
TSG101 TSG101 Q99816 Tumor susceptibility gene 101 protein chr11 Not Cancer Driver No 1 intact 46 159 23 23 0
VAV1 VAV1 P15498 Proto-oncogene vav chr19 Census, Compendium Yes 1 intact, hippie 165 113 19 19 0
VCP VCP P55072 Transitional endoplasmic reticulum ATPase chr9 Not Cancer Driver No 1 intact, hippie 88 186 16 16 16
VIM_ENST00000224237 VIM P08670 Vimentin chr10 Not Cancer Driver No 1 intact, hippie 84 316 57 57 1
WAS WAS P42768 Wiskott-Aldrich syndrome protein chrX Census, Compendium Yes 1 intact, hippie 75 400 55 55 30
ZAP70 ZAP70 P43403 Tyrosine-protein kinase ZAP-70 chr2 Not Cancer Driver No 1 intact, hippie 126 117 17 17 8