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PSEN2 ,PSEN2 ,P49810
  • Uniprot Accession= P49810
  • Ensembl Transcript= ENST00000366783.7
  • Uniprot Name= PSEN2
  • Name= Presenilin-2
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 37
  • Number of Interaction partner in biogrid: 9
  • Number of Interaction partner in hippie: 109
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
AAMP_ENST00000248450 AAMP Q13685 Angio-associated migratory cell protein chr2 Not Cancer Driver No 1 hippie 31 126 10 10 0
ACTG1_ENST00000575087 ACTG1 P63261 Actin, cytoplasmic 2 chr17 Not Cancer Driver No 1 hippie 73 42 10 10 16
AK2 AK2 P54819 Adenylate kinase 2, mitochondrial chr1 Not Cancer Driver No 1 intact, hippie 23 76 12 12 2
AL645941.2 HLA-DMB A0A140T9U6 HLA class II histocompatibility antigen, DM beta chain (Fragment) chr6 Not Cancer Driver No 1 intact, hippie 20 19 2 2 0
ALG5 ALG5 Q9Y673 Dolichyl-phosphate beta-glucosyltransferase chr13 Not Cancer Driver No 1 hippie, biogrid 40 0 0 0 0
AP1G1_ENST00000569748 AP1G1 O43747 AP-1 complex subunit gamma-1 chr16 Not Cancer Driver No 1 hippie 111 144 22 22 0
APBA1 APBA1 Q02410 Amyloid-beta A4 precursor protein-binding family A member 1 chr9 Not Cancer Driver No 1 hippie 149 556 103 103 0
APBA2_ENST00000561069 APBA2 Q99767 Amyloid-beta A4 precursor protein-binding family A member 2 chr15 Not Cancer Driver No 1 hippie 184 429 117 117 0
APBA3 APBA3 O96018 Amyloid-beta A4 precursor protein-binding family A member 3 chr19 Not Cancer Driver No 1 hippie 55 306 43 43 0
APH1A APH1A Q96BI3 Gamma-secretase subunit APH-1A chr1 Not Cancer Driver No 1 hippie 32 0 0 0 0
APH1B APH1B Q8WW43 Gamma-secretase subunit APH-1B chr15 Not Cancer Driver No 1 hippie 21 0 0 0 0
APP APP P05067 Amyloid-beta precursor protein chr21 Not Cancer Driver No 2 intact, hippie 128 418 71 71 17
ARL16 ARL16 Q0P5N6 ADP-ribosylation factor-like protein 16 chr17 Not Cancer Driver No 1 intact, hippie 26 29 7 7 0
ART3 ART3 Q13508 Ecto-ADP-ribosyltransferase 3 chr4 Not Cancer Driver No 1 hippie, biogrid 54 82 12 12 0
AURKA_ENST00000395915 AURKA O14965 Aurora kinase A chr20 Not Cancer Driver No 1 hippie 36 178 21 21 0
BAK1 BAK1 Q16611 Bcl-2 homologous antagonist/killer chr6 Not Cancer Driver No 1 hippie 38 58 9 9 0
BCL2L1 BCL2L1 Q07817 Bcl-2-like protein 1 chr20 Not Cancer Driver No 1 intact, hippie 29 55 3 3 0
BCL2_ENST00000333681 BCL2 P10415 Apoptosis regulator Bcl-2 chr18 Census, Compendium Yes 1 hippie 24 72 5 5 0
CAPN1_ENST00000533129 CAPN1 P07384 Calpain-1 catalytic subunit chr11 Not Cancer Driver No 1 hippie 68 32 2 2 1
CASP1 CASP1 P29466 Caspase-1 chr11 Not Cancer Driver No 2 intact, hippie 79 87 18 18 0
CASP3 CASP3 P42574 Caspase-3 chr4 Census Yes 1 hippie 32 62 5 5 0
CASP6 CASP6 P55212 Caspase-6 chr4 Not Cancer Driver No 1 hippie 28 24 4 4 0
CASP7_ENST00000345633 CASP7 P55210 Caspase-7 chr10 Not Cancer Driver No 1 hippie 38 73 10 10 0
CASP8_ENST00000432109 CASP8 Q14790 Caspase-8 chr2 Census, Compendium Yes 1 hippie 142 106 12 12 1
CEP55 CEP55 Q53EZ4 Centrosomal protein of 55 kDa chr10 Not Cancer Driver No 1 hippie 59 264 26 26 0
CFLAR CFLAR O15519 CASP8 and FADD-like apoptosis regulator chr2 Not Cancer Driver No 1 hippie 40 44 2 2 0
CHKA CHKA P35790 Choline kinase alpha chr11 Not Cancer Driver No 1 hippie 45 119 4 4 0
CIB1_ENST00000328649 CIB1 Q99828 Calcium and integrin-binding protein 1 chr15 Not Cancer Driver No 1 hippie 24 6 1 1 0
CLK1_ENST00000321356 CLK1 P49759 Dual specificity protein kinase CLK1 chr2 Not Cancer Driver No 1 hippie 64 131 21 21 0
COX4I1 COX4I1 P13073 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial chr16 Not Cancer Driver No 1 intact 17 5 1 1 1
CSNK1A1_ENST00000377843 CSNK1A1 P48729 Casein kinase I isoform alpha chr5 Not Cancer Driver No 1 hippie 44 46 3 3 0
CSNK1D CSNK1D P48730 Casein kinase I isoform delta chr17 Not Cancer Driver No 1 hippie 59 132 16 16 2
CSNK2A1_ENST00000400217 CSNK2A1 P68400 Casein kinase II subunit alpha chr20 Not Cancer Driver No 1 hippie 71 75 8 8 4
CTNNB1_ENST00000643977 CTNNB1 P35222 Catenin beta-1 chr3 Census, Compendium Yes 1 hippie 415 288 301 301 14
CTNND2 CTNND2 Q9UQB3 Catenin delta-2 chr5 Census Yes 1 hippie 386 837 254 254 0
DLK1 DLK1 P80370 Protein delta homolog 1 chr14 Not Cancer Driver No 1 hippie, biogrid 81 0 0 0 0
DNAJB1 DNAJB1 P25685 DnaJ homolog subfamily B member 1 chr19 Census, Compendium Yes 1 intact, hippie 35 196 26 26 0
DOCK3 DOCK3 Q8IZD9 Dedicator of cytokinesis protein 3 chr3 Not Cancer Driver No 1 hippie 365 458 69 69 0
DYNC1H1 DYNC1H1 Q14204 Cytoplasmic dynein 1 heavy chain 1 chr14 Not Cancer Driver No 1 intact, hippie 505 495 62 62 21
ECD_ENST00000372979 ECD O95905 Protein ecdysoneless homolog chr10 Not Cancer Driver No 1 hippie 68 254 26 26 0
ECSIT ECSIT Q9BQ95 Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial chr19 Not Cancer Driver No 1 hippie 58 146 29 29 0
EID1 EID1 Q9Y6B2 EP300-interacting inhibitor of differentiation 1 chr15 Not Cancer Driver No 1 intact, hippie 22 159 17 17 0
ELAVL1 ELAVL1 Q15717 ELAV-like protein 1 chr19 Not Cancer Driver No 1 hippie 69 43 5 5 0
ELL2 ELL2 O00472 RNA polymerase II elongation factor ELL2 chr5 Not Cancer Driver No 1 intact, hippie 90 421 63 63 0
ERGIC3_ENST00000348547 ERGIC3 Q9Y282 Endoplasmic reticulum-Golgi intermediate compartment protein 3 chr20 Not Cancer Driver No 1 hippie, biogrid 53 23 3 3 0
EVI5L_ENST00000270530 EVI5L Q96CN4 EVI5-like protein chr19 Not Cancer Driver No 1 hippie 70 381 27 27 0
EXOC6 EXOC6 Q8TAG9 Exocyst complex component 6 chr10 Not Cancer Driver No 1 intact, hippie 100 104 11 11 0
FAF2 FAF2 Q96CS3 FAS-associated factor 2 chr5 Not Cancer Driver No 1 hippie, biogrid 54 171 16 16 0
FBXL12 FBXL12 Q9NXK8 F-box/LRR-repeat protein 12 chr19 Not Cancer Driver No 1 hippie 41 0 0 0 0
FHL2_ENST00000408995 FHL2 Q14192 Four and a half LIM domains protein 2 chr2 Not Cancer Driver No 1 hippie 30 0 0 0 0
FKBP8_ENST00000222308 FKBP8 Q14318 Peptidyl-prolyl cis-trans isomerase FKBP8 chr19 Not Cancer Driver No 1 hippie 71 160 25 25 0
FLNA FLNA P21333 Filamin-A chrX Census Yes 1 intact, hippie 416 1456 214 214 28
FLNB_ENST00000295956 FLNB O75369 Filamin-B chr3 Not Cancer Driver No 1 intact, hippie 362 1183 170 170 19
FTL FTL P02792 Ferritin light chain chr19 Not Cancer Driver No 1 intact, hippie 19 36 7 7 2
GCDH_ENST00000591470 GCDH Q92947 Glutaryl-CoA dehydrogenase, mitochondrial chr19 Not Cancer Driver No 1 hippie 57 37 5 5 58
GFAP_ENST00000588735 GFAP P14136 Glial fibrillary acidic protein chr17 Not Cancer Driver No 1 hippie 65 288 42 42 62
HLA-DMB HLA-DMB P28068 HLA class II histocompatibility antigen, DM beta chain chr6 Not Cancer Driver No 1 intact, hippie 41 41 9 9 0
HNRNPLL HNRNPLL Q8WVV9 Heterogeneous nuclear ribonucleoprotein L-like chr2 Not Cancer Driver No 1 intact, hippie 37 149 13 13 0
HPS1_ENST00000613394 HPS1 Q92902 Hermansky-Pudlak syndrome 1 protein chr10 Not Cancer Driver No 1 hippie 72 154 16 16 0
ICAM5 ICAM5 Q9UMF0 Intercellular adhesion molecule 5 chr19 Not Cancer Driver No 1 hippie 103 419 47 47 0
IFIT3_ENST00000371811 IFIT3 O14879 Interferon-induced protein with tetratricopeptide repeats 3 chr10 Not Cancer Driver No 1 hippie 47 143 11 11 0
IFIT5 IFIT5 Q13325 Interferon-induced protein with tetratricopeptide repeats 5 chr10 Not Cancer Driver No 1 hippie 43 19 0 0 0
IRF3_ENST00000597198 IRF3 Q14653 Interferon regulatory factor 3 chr19 Not Cancer Driver No 1 hippie, biogrid 36 204 21 21 1
KCNIP3 KCNIP3 Q9Y2W7 Calsenilin chr2 Not Cancer Driver No 1 hippie 39 60 13 13 0
KCNIP4 KCNIP4 Q6PIL6 Kv channel-interacting protein 4 chr4 Not Cancer Driver No 1 hippie 59 30 13 13 0
KIF22 KIF22 Q14807 Kinesin-like protein KIF22 chr16 Not Cancer Driver No 1 hippie 79 322 35 35 4
LIPF_ENST00000238983 LIPF P07098 Gastric triacylglycerol lipase chr10 Not Cancer Driver No 1 intact, hippie 74 0 0 0 0
MAST1 MAST1 Q9Y2H9 Microtubule-associated serine/threonine-protein kinase 1 chr19 Not Cancer Driver No 1 intact, hippie 204 1078 119 119 1
MGARP MGARP Q8TDB4 Protein MGARP chr4 Not Cancer Driver No 1 intact, hippie 25 207 22 22 0
MICAL2_ENST00000646065 MICAL2 O94851 [F-actin]-monooxygenase MICAL2 chr11 Not Cancer Driver No 1 hippie 297 1191 179 179 0
MNDA MNDA P41218 Myeloid cell nuclear differentiation antigen chr1 Not Cancer Driver No 1 intact, hippie 180 172 76 76 0
MRFAP1L1 MRFAP1L1 Q96HT8 MORF4 family-associated protein 1-like 1 chr4 Not Cancer Driver No 1 hippie 12 59 5 5 0
NCSTN NCSTN Q92542 Nicastrin chr1 Not Cancer Driver No 1 hippie 94 72 11 11 1
NEBL NEBL O76041 Nebulette chr10 Not Cancer Driver No 1 intact, hippie 239 773 183 183 0
NOS3 NOS3 P29474 Nitric oxide synthase, endothelial chr7 Not Cancer Driver No 1 hippie 168 347 38 38 0
NOTCH1 NOTCH1 P46531 Neurogenic locus notch homolog protein 1 chr9 Census, Compendium Yes 1 hippie 363 686 87 87 3
NOTCH2 NOTCH2 Q04721 Neurogenic locus notch homolog protein 2 chr1 Census, Compendium Yes 1 hippie 282 630 77 77 1
NOTCH3 NOTCH3 Q9UM47 Neurogenic locus notch homolog protein 3 chr19 Not Cancer Driver No 1 hippie 306 557 81 81 110
NOTCH4 NOTCH4 Q99466 Neurogenic locus notch homolog protein 4 chr6 Not Cancer Driver No 1 hippie 336 464 79 79 0
NPLOC4 NPLOC4 Q8TAT6 Nuclear protein localization protein 4 homolog chr17 Not Cancer Driver No 1 intact, hippie, biogrid 78 47 8 8 0
OGA OGA O60502 Protein O-GlcNAcase chr10 Not Cancer Driver No 1 hippie 89 241 15 15 0
PDCD4 PDCD4 Q53EL6 Programmed cell death protein 4 chr10 Not Cancer Driver No 1 intact, hippie 57 187 32 32 0
PDZK1IP1_ENST00000371885 PDZK1IP1 Q13113 PDZK1-interacting protein 1 chr1 Not Cancer Driver No 1 hippie 22 21 0 0 0
PIK3R1 PIK3R1 P27986 Phosphatidylinositol 3-kinase regulatory subunit alpha chr5 Census, Compendium Yes 1 intact, hippie 154 268 61 61 2
PPP5C PPP5C P53041 Serine/threonine-protein phosphatase 5 chr19 Not Cancer Driver No 1 hippie 70 73 12 12 0
PSEN1 PSEN1 P49768 Presenilin-1 chr14 Not Cancer Driver No 2 intact, hippie 61 134 21 21 96
PSEN2 PSEN2 P49810 Presenilin-2 chr1 Not Cancer Driver No 1 hippie 68 89 16 16 7
PSENEN_ENST00000222266 PSENEN Q9NZ42 Gamma-secretase subunit PEN-2 chr19 Not Cancer Driver No 1 hippie 17 0 0 0 0
RAB11A RAB11A P62491 Ras-related protein Rab-11A chr15 Not Cancer Driver No 1 intact, hippie 31 43 4 4 0
RHEB RHEB Q15382 GTP-binding protein Rheb chr7 Not Cancer Driver No 1 hippie 30 0 0 0 0
RNF115 RNF115 Q9Y4L5 E3 ubiquitin-protein ligase RNF115 chr1 Not Cancer Driver No 1 intact, hippie, biogrid 30 136 14 14 0
RNF2 RNF2 Q99496 E3 ubiquitin-protein ligase RING2 chr1 Not Cancer Driver No 1 hippie 40 203 22 22 0
RNF32_ENST00000432459 RNF32 Q9H0A6 RING finger protein 32 chr7 Not Cancer Driver No 1 intact, hippie 60 109 20 20 0
RYBP RYBP Q8N488 RING1 and YY1-binding protein chr3 Not Cancer Driver No 1 hippie 37 214 37 37 0
SGSM1 SGSM1 Q2NKQ1 Small G protein signaling modulator 1 chr22 Not Cancer Driver No 1 intact, hippie 206 418 68 68 0
SLC6A13 SLC6A13 Q9NSD5 Sodium- and chloride-dependent GABA transporter 2 chr12 Not Cancer Driver No 1 intact, hippie 136 37 11 11 0
SOX14 SOX14 O95416 Transcription factor SOX-14 chr3 Not Cancer Driver No 1 hippie 48 128 32 32 0
SP6_ENST00000342234 SP6 Q3SY56 Transcription factor Sp6 chr17 Not Cancer Driver No 1 intact, hippie 55 296 39 39 0
SPC24 SPC24 Q8NBT2 Kinetochore protein Spc24 chr19 Not Cancer Driver No 1 hippie 9 88 5 5 0
SRI SRI P30626 Sorcin chr7 Not Cancer Driver No 1 hippie 15 32 2 2 0
TMBIM6_ENST00000549385 TMBIM6 P55061 Bax inhibitor 1 chr12 Not Cancer Driver No 1 hippie 16 3 0 0 0
TRAF6_ENST00000348124 TRAF6 Q9Y4K3 TNF receptor-associated factor 6 chr11 Not Cancer Driver No 1 hippie 67 62 7 7 0
TSPAN5 TSPAN5 P62079 Tetraspanin-5 chr4 Not Cancer Driver No 1 hippie, biogrid 49 0 0 0 0
UBAC1 UBAC1 Q9BSL1 Ubiquitin-associated domain-containing protein 1 chr9 Not Cancer Driver No 1 hippie 38 241 23 23 0
UBQLN1 UBQLN1 Q9UMX0 Ubiquilin-1 chr9 Not Cancer Driver No 1 hippie 64 543 58 58 0
WDR61 WDR61 Q9GZS3 WD repeat-containing protein 61 chr15 Not Cancer Driver No 1 intact, hippie 25 7 1 1 0
ZMAT2 ZMAT2 Q96NC0 Zinc finger matrin-type protein 2 chr5 Not Cancer Driver No 1 intact, hippie 24 148 19 19 0
ZNF366 ZNF366 Q8N895 Zinc finger protein 366 chr5 Not Cancer Driver No 1 intact, hippie 158 382 85 85 0
ZSCAN1 ZSCAN1 Q8NBB4 Zinc finger and SCAN domain-containing protein 1 chr19 Not Cancer Driver No 1 intact, hippie 132 298 98 98 0
ZXDC ZXDC Q2QGD7 Zinc finger protein ZXDC chr3 Not Cancer Driver No 1 intact, hippie 81 551 49 49 0