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PRKCZ ,PRKCZ ,Q05513
  • Uniprot Accession= Q05513
  • Ensembl Transcript= ENST00000378567.7
  • Uniprot Name= PRKCZ
  • Name= Protein kinase C zeta type
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 141
  • Number of Interaction partner in biogrid: 137
  • Number of Interaction partner in hippie: 385
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ABL1_ENST00000318560 ABL1 P00519 Tyrosine-protein kinase ABL1 chr9 Census, Compendium Yes 1 hippie 139 604 73 73 2
ACAT1 ACAT1 P24752 Acetyl-CoA acetyltransferase, mitochondrial chr11 Not Cancer Driver No 1 hippie, biogrid 45 32 1 1 10
ACLY_ENST00000590151 ACLY P53396 ATP-citrate synthase chr17 Not Cancer Driver No 1 intact, hippie, biogrid 120 114 12 12 0
ACTN4 ACTN4 O43707 Alpha-actinin-4 chr19 Not Cancer Driver No 1 intact, hippie, biogrid 131 244 42 42 8
ACTR3 ACTR3 P61158 Actin-related protein 3 chr2 Not Cancer Driver No 1 intact, hippie, biogrid 32 16 2 2 0
ADAP1_ENST00000265846 ADAP1 O75689 Arf-GAP with dual PH domain-containing protein 1 chr7 Not Cancer Driver No 1 hippie 33 30 3 3 0
ADCY5 ADCY5 O95622 Adenylate cyclase type 5 chr3 Not Cancer Driver No 1 hippie 234 268 23 23 2
ADH1C ADH1C P00326 Alcohol dehydrogenase 1C chr4 Not Cancer Driver No 1 hippie 116 6 5 5 0
AFAP1_ENST00000358461 AFAP1 Q8N556 Actin filament-associated protein 1 chr4 Not Cancer Driver No 1 hippie 104 487 60 60 0
AGER_ENST00000375076 AGER Q15109 Advanced glycosylation end product-specific receptor chr6 Not Cancer Driver No 1 intact, hippie 31 297 21 21 0
AHCY AHCY P23526 Adenosylhomocysteinase chr20 Not Cancer Driver No 1 hippie, biogrid 58 0 0 0 4
AHSA1 AHSA1 O95433 Activator of 90 kDa heat shock protein ATPase homolog 1 chr14 Not Cancer Driver No 1 hippie, biogrid 46 146 17 17 0
AHSG AHSG P02765 Alpha-2-HS-glycoprotein chr3 Not Cancer Driver No 1 intact, hippie, biogrid 74 131 41 41 0
AIFM1 AIFM1 O95831 Apoptosis-inducing factor 1, mitochondrial chrX Not Cancer Driver No 1 intact, hippie 88 166 22 22 11
AJUBA AJUBA Q96IF1 LIM domain-containing protein ajuba chr14 Compendium Yes 1 hippie 45 307 13 13 0
AKT1_ENST00000349310 AKT1 P31749 RAC-alpha serine/threonine-protein kinase chr14 Census, Compendium Yes 2 intact, hippie 108 158 24 24 4
AKT2 AKT2 P31751 RAC-beta serine/threonine-protein kinase chr19 Census Yes 1 hippie 77 84 9 9 2
AKT3_ENST00000366539 AKT3 Q9Y243 RAC-gamma serine/threonine-protein kinase chr1 Census, Compendium Yes 2 intact, hippie 92 131 24 24 3
AL662899.2_ENST00000375880 CSNK2B Q5SRQ3 Casein kinase II subunit beta chr6 Not Cancer Driver No 1 hippie 21 30 1 1 0
ALDH18A1 ALDH18A1 P54886 Delta-1-pyrroline-5-carboxylate synthase chr10 Not Cancer Driver No 1 intact, hippie, biogrid 94 86 13 13 15
AMHR2 AMHR2 Q16671 Anti-Muellerian hormone type-2 receptor chr12 Not Cancer Driver No 1 biogrid 77 117 7 7 8
ANXA2_ENST00000396024 ANXA2 P07355 Annexin A2 chr15 Not Cancer Driver No 1 hippie 49 20 4 4 0
AP2A2_ENST00000448903 AP2A2 O94973 AP-2 complex subunit alpha-2 chr11 Not Cancer Driver No 1 intact, hippie 100 145 12 12 0
AP2M1_ENST00000292807 AP2M1 Q96CW1 AP-2 complex subunit mu chr3 Not Cancer Driver No 1 hippie 55 41 9 9 1
AP3S1 AP3S1 Q92572 AP-3 complex subunit sigma-1 chr5 Not Cancer Driver No 1 intact, hippie 35 0 0 0 0
API5 API5 Q9BZZ5 Apoptosis inhibitor 5 chr11 Not Cancer Driver No 1 hippie 65 92 10 10 0
APPL1 APPL1 Q9UKG1 DCC-interacting protein 13-alpha chr3 Not Cancer Driver No 1 hippie 67 292 31 31 1
ARHGDIA_ENST00000580685 ARHGDIA P52565 Rho GDP-dissociation inhibitor 1 chr17 Not Cancer Driver No 1 hippie, biogrid 25 50 6 6 0
ARMC8_ENST00000469044 ARMC8 Q8IUR7 Armadillo repeat-containing protein 8 chr3 Not Cancer Driver No 1 hippie, biogrid 71 7 0 0 0
ASPH ASPH Q12797 Aspartyl/asparaginyl beta-hydroxylase chr8 Not Cancer Driver No 1 intact, hippie 109 373 53 53 1
ATP1A1_ENST00000295598 ATP1A1 P05023 Sodium/potassium-transporting ATPase subunit alpha-1 chr1 Census Yes 1 intact, hippie, biogrid 115 115 16 16 6
ATP1B3 ATP1B3 P54709 Sodium/potassium-transporting ATPase subunit beta-3 chr3 Not Cancer Driver No 1 hippie, biogrid 36 6 1 1 0
BAG2 BAG2 O95816 BAG family molecular chaperone regulator 2 chr6 Not Cancer Driver No 2 intact, hippie 17 112 9 9 0
BASP1_ENST00000616743 BASP1 P80723 Brain acid soluble protein 1 chr5 Not Cancer Driver No 1 intact, hippie, biogrid 39 227 39 39 0
BCL10 BCL10 O95999 B-cell lymphoma/leukemia 10 chr1 Census, Compendium Yes 1 intact, hippie 36 151 25 25 0
BEGAIN BEGAIN Q9BUH8 Brain-enriched guanylate kinase-associated protein chr14 Not Cancer Driver No 1 hippie, biogrid 53 409 37 37 0
BLVRA BLVRA P53004 Biliverdin reductase A chr7 Not Cancer Driver No 1 hippie 34 6 1 1 0
BRSK1 BRSK1 Q8TDC3 Serine/threonine-protein kinase BRSK1 chr19 Not Cancer Driver No 1 hippie, biogrid 131 459 78 78 0
BSG BSG P35613 Basigin chr19 Not Cancer Driver No 1 hippie, biogrid 43 123 17 17 0
BTK_ENST00000308731 BTK Q06187 Tyrosine-protein kinase BTK chrX Census, Compendium Yes 1 hippie 147 114 27 27 110
C1QBP C1QBP Q07021 Complement component 1 Q subcomponent-binding protein, mitochondrial chr17 Not Cancer Driver No 3 intact, hippie 14 103 6 6 2
CAD CAD P27708 CAD protein chr2 Not Cancer Driver No 1 intact, hippie 287 368 52 52 1
CALR CALR P27797 Calreticulin chr19 Census Yes 1 hippie, biogrid 45 245 31 31 0
CALU_ENST00000249364 CALU O43852 Calumenin chr7 Not Cancer Driver No 2 intact, hippie, biogrid 34 130 12 12 0
CAMSAP3_ENST00000160298 CAMSAP3 Q9P1Y5 Calmodulin-regulated spectrin-associated protein 3 chr19 Not Cancer Driver No 1 intact, hippie 132 889 81 81 0
CAND1 CAND1 Q86VP6 Cullin-associated NEDD8-dissociated protein 1 chr12 Not Cancer Driver No 1 hippie, biogrid 161 88 7 7 0
CANX_ENST00000504734 CANX P27824 Calnexin chr5 Not Cancer Driver No 1 intact, hippie, biogrid 65 334 38 38 0
CAP1_ENST00000372805 CAP1 Q01518 Adenylyl cyclase-associated protein 1 chr1 Not Cancer Driver No 1 intact, hippie, biogrid 70 156 31 31 0
CASP3 CASP3 P42574 Caspase-3 chr4 Census Yes 1 hippie 32 62 5 5 0
CASP6 CASP6 P55212 Caspase-6 chr4 Not Cancer Driver No 1 hippie 28 24 4 4 0
CASP7_ENST00000345633 CASP7 P55210 Caspase-7 chr10 Not Cancer Driver No 1 hippie 38 73 10 10 0
CASP8_ENST00000432109 CASP8 Q14790 Caspase-8 chr2 Census, Compendium Yes 1 hippie 142 106 12 12 1
CASP9 CASP9 P55211 Caspase-9 chr1 Census Yes 1 hippie 49 71 7 7 0
CAVIN1 CAVIN1 Q6NZI2 Caveolae-associated protein 1 chr17 Not Cancer Driver No 1 hippie 66 280 50 50 0
CAVIN2 CAVIN2 O95810 Caveolae-associated protein 2 chr2 Not Cancer Driver No 1 hippie 109 393 99 99 0
CCDC115 CCDC115 Q96NT0 Coiled-coil domain-containing protein 115 chr2 Not Cancer Driver No 1 intact, hippie 21 89 8 8 2
CCT2 CCT2 P78371 T-complex protein 1 subunit beta chr12 Not Cancer Driver No 1 hippie 63 46 3 3 0
CCT5 CCT5 P48643 T-complex protein 1 subunit epsilon chr5 Not Cancer Driver No 1 hippie 83 72 10 10 1
CCT6A CCT6A P40227 T-complex protein 1 subunit zeta chr7 Not Cancer Driver No 1 hippie 66 5 1 1 0
CD44 CD44 P16070 CD44 antigen chr11 Not Cancer Driver No 1 hippie 75 542 60 60 0
CDC37 CDC37 Q16543 Hsp90 co-chaperone Cdc37 chr19 Not Cancer Driver No 2 intact, hippie 52 214 31 31 0
CDC42BPB CDC42BPB Q9Y5S2 Serine/threonine-protein kinase MRCK beta chr14 Not Cancer Driver No 2 hippie, biogrid 185 696 92 92 0
CDC42_ENST00000344548 CDC42 P60953 Cell division control protein 42 homolog chr1 Not Cancer Driver No 1 hippie 39 23 2 2 1
CDK1 CDK1 P06493 Cyclin-dependent kinase 1 chr10 Not Cancer Driver No 1 hippie, biogrid 40 1 0 0 0
CFL1_ENST00000308162 CFL1 P23528 Cofilin-1 chr11 Not Cancer Driver No 1 hippie 21 4 0 0 0
CHAT CHAT P28329 Choline O-acetyltransferase chr10 Not Cancer Driver No 1 hippie 155 193 24 24 10
CHCHD2 CHCHD2 Q9Y6H1 Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 chr7 Not Cancer Driver No 1 hippie 24 114 21 21 1
CKAP4 CKAP4 Q07065 Cytoskeleton-associated protein 4 chr12 Not Cancer Driver No 1 hippie 73 409 55 55 0
CLTC_ENST00000269122 CLTC Q00610 Clathrin heavy chain 1 chr17 Census, Compendium Yes 1 hippie 190 71 6 6 1
COPB1_ENST00000439561 COPB1 P53618 Coatomer subunit beta chr11 Not Cancer Driver No 1 hippie 110 95 10 10 1
COX4I1 COX4I1 P13073 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial chr16 Not Cancer Driver No 1 intact, hippie, biogrid 17 5 1 1 1
CPSF6_ENST00000435070 CPSF6 Q16630 Cleavage and polyadenylation specificity factor subunit 6 chr12 Not Cancer Driver No 1 intact, hippie, biogrid 85 484 75 75 0
CPT1A_ENST00000539743 CPT1A P50416 Carnitine O-palmitoyltransferase 1, liver isoform chr11 Not Cancer Driver No 1 intact, hippie 144 62 10 10 15
CS CS O75390 Citrate synthase, mitochondrial chr12 Not Cancer Driver No 1 intact, hippie, biogrid 50 13 2 2 0
CSE1L CSE1L P55060 Exportin-2 chr20 Not Cancer Driver No 1 hippie, biogrid 109 32 5 5 0
CSNK2A1_ENST00000400217 CSNK2A1 P68400 Casein kinase II subunit alpha chr20 Not Cancer Driver No 1 intact, hippie 71 75 8 8 4
CSNK2A3 CSNK2A3 Q8NEV1 Casein kinase II subunit alpha 3 chr11 Not Cancer Driver No 1 intact, hippie 66 75 10 10 0
CSNK2B_ENST00000375866 CSNK2B P67870 Casein kinase II subunit beta chr6 Not Cancer Driver No 1 hippie 20 19 0 0 4
CYB5R3_ENST00000352397 CYB5R3 P00387 NADH-cytochrome b5 reductase 3 chr22 Not Cancer Driver No 1 hippie, biogrid 42 24 3 3 9
CYCS_ENST00000409409 CYCS P99999 Cytochrome c chr7 Not Cancer Driver No 1 intact, hippie, biogrid 12 19 3 3 1
DAPK3_ENST00000301264 DAPK3 O43293 Death-associated protein kinase 3 chr19 Not Cancer Driver No 1 hippie 56 82 7 7 0
DCAF1 DCAF1 Q9Y4B6 DDB1- and CUL4-associated factor 1 chr3 Not Cancer Driver No 1 intact, hippie 128 495 44 44 0
DDA1 DDA1 Q9BW61 DET1- and DDB1-associated protein 1 chr19 Not Cancer Driver No 1 intact, hippie 10 70 9 9 0
DDB1 DDB1 Q16531 DNA damage-binding protein 1 chr11 Not Cancer Driver No 1 intact 126 50 8 8 4
DDOST_ENST00000375048 DDOST P39656 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit chr1 Not Cancer Driver No 1 intact, hippie, biogrid 34 13 3 3 1
DDX3X_ENST00000629496 DDX3X O00571 ATP-dependent RNA helicase DDX3X chrX Census, Compendium Yes 1 hippie 133 301 47 47 18
DENND5A DENND5A Q6IQ26 DENN domain-containing protein 5A chr11 Not Cancer Driver No 1 intact, hippie 134 231 21 21 0
DLG4_ENST00000399506 DLG4 P78352 Disks large homolog 4 chr17 Not Cancer Driver No 5 intact 116 232 55 55 0
DNAJA1 DNAJA1 P31689 DnaJ homolog subfamily A member 1 chr9 Not Cancer Driver No 1 intact, hippie 37 153 16 16 0
DNAJA2 DNAJA2 O60884 DnaJ homolog subfamily A member 2 chr16 Not Cancer Driver No 1 intact, hippie 50 174 27 27 0
DNAJC13 DNAJC13 O75165 DnaJ homolog subfamily C member 13 chr3 Not Cancer Driver No 1 hippie 276 141 17 17 0
DYNLL1_ENST00000242577 DYNLL1 P63167 Dynein light chain 1, cytoplasmic chr12 Not Cancer Driver No 1 intact, hippie 9 0 0 0 0
ECHS1 ECHS1 P30084 Enoyl-CoA hydratase, mitochondrial chr10 Not Cancer Driver No 1 hippie, biogrid 51 7 1 1 14
ECT2 ECT2 Q9H8V3 Protein ECT2 chr3 Not Cancer Driver No 1 hippie 104 284 33 33 0
EEF1A1 EEF1A1 P68104 Elongation factor 1-alpha 1 chr6 Not Cancer Driver No 1 hippie 109 100 14 14 0
EEF1B2_ENST00000236957 EEF1B2 P24534 Elongation factor 1-beta chr2 Not Cancer Driver No 1 hippie 63 71 11 11 0
EEF1D_ENST00000395119 EEF1D P29692 Elongation factor 1-delta chr8 Not Cancer Driver No 1 hippie 40 153 22 22 0
EEF1G EEF1G P26641 Elongation factor 1-gamma chr11 Not Cancer Driver No 1 hippie 44 66 5 5 0
EEF2 EEF2 P13639 Elongation factor 2 chr19 Not Cancer Driver No 1 intact, hippie, biogrid 111 78 14 14 1
EGFR EGFR P00533 Epidermal growth factor receptor chr7 Census, Compendium Yes 1 hippie 444 223 35 35 1
EIF3B_ENST00000397011 EIF3B P55884 Eukaryotic translation initiation factor 3 subunit B chr7 Not Cancer Driver No 1 hippie 89 226 4 4 0
EIF3E EIF3E P60228 Eukaryotic translation initiation factor 3 subunit E chr8 Census, Compendium Yes 1 hippie 73 27 1 1 0
EIF3H EIF3H O15372 Eukaryotic translation initiation factor 3 subunit H chr8 Not Cancer Driver No 1 hippie 37 109 12 12 0
EIF3L EIF3L Q9Y262 Eukaryotic translation initiation factor 3 subunit L chr22 Not Cancer Driver No 1 hippie 60 41 1 1 0
EIF4A1 EIF4A1 P60842 Eukaryotic initiation factor 4A-I chr17 Not Cancer Driver No 1 hippie 48 35 7 7 0
EIF5A_ENST00000419711 EIF5A P63241 Eukaryotic translation initiation factor 5A-1 chr17 Not Cancer Driver No 2 intact, hippie, biogrid 37 21 5 5 5
EPB41L4B EPB41L4B Q9H329 Band 4.1-like protein 4B chr9 Not Cancer Driver No 1 intact, hippie 131 548 77 77 0
EPHB4 EPHB4 P54760 Ephrin type-B receptor 4 chr7 Not Cancer Driver No 1 biogrid 125 184 19 19 11
ESR1_ENST00000206249 ESR1 P03372 Estrogen receptor chr6 Census, Compendium Yes 1 hippie 121 195 27 27 2
EZR EZR P15311 Ezrin chr6 Census Yes 1 intact, hippie, biogrid 66 295 35 35 0
F11R F11R Q9Y624 Junctional adhesion molecule A chr1 Not Cancer Driver No 1 hippie 47 72 15 15 0
FADD FADD Q13158 FAS-associated death domain protein chr11 Not Cancer Driver No 1 hippie 26 45 10 10 1
FARP2 FARP2 O94887 FERM, ARHGEF and pleckstrin domain-containing protein 2 chr2 Not Cancer Driver No 1 hippie 133 250 39 39 0
FASN FASN P49327 Fatty acid synthase chr17 Not Cancer Driver No 1 intact, hippie, biogrid 291 309 42 42 0
FAT1 FAT1 Q14517 Protocadherin Fat 1 chr4 Census, Compendium Yes 1 hippie 663 1051 126 126 0
FBL FBL P22087 rRNA 2'-O-methyltransferase fibrillarin chr19 Not Cancer Driver No 1 intact, hippie 46 145 22 22 0
FEZ1 FEZ1 Q99689 Fasciculation and elongation protein zeta-1 chr11 Not Cancer Driver No 1 hippie 66 277 49 49 0
FEZ2_ENST00000405912 FEZ2 Q9UHY8 Fasciculation and elongation protein zeta-2 chr2 Not Cancer Driver No 1 hippie 37 245 29 29 0
FKBP3_ENST00000396062 FKBP3 Q00688 Peptidyl-prolyl cis-trans isomerase FKBP3 chr14 Not Cancer Driver No 1 intact, hippie, biogrid 27 131 17 17 0
FKBP4 FKBP4 Q02790 Peptidyl-prolyl cis-trans isomerase FKBP4 chr12 Not Cancer Driver No 1 hippie, biogrid 46 134 12 12 0
FLNA FLNA P21333 Filamin-A chrX Census Yes 1 hippie 416 1456 214 214 28
FLNC FLNC Q14315 Filamin-C chr7 Not Cancer Driver No 1 hippie 546 1442 288 288 7
FRS2 FRS2 Q8WU20 Fibroblast growth factor receptor substrate 2 chr12 Not Cancer Driver No 1 hippie 69 415 58 58 0
FYN FYN P06241 Tyrosine-protein kinase Fyn chr6 Not Cancer Driver No 1 hippie 92 70 13 13 0
GABARAP GABARAP O95166 Gamma-aminobutyric acid receptor-associated protein chr17 Not Cancer Driver No 1 hippie 9 11 0 0 0
GANAB_ENST00000356638 GANAB Q14697 Neutral alpha-glucosidase AB chr11 Not Cancer Driver No 1 intact, hippie, biogrid 129 132 20 20 3
GAPDH GAPDH P04406 Glyceraldehyde-3-phosphate dehydrogenase chr12 Not Cancer Driver No 1 hippie 39 24 3 3 0
GART_ENST00000381815 GART P22102 Trifunctional purine biosynthetic protein adenosine-3 chr21 Not Cancer Driver No 1 intact, hippie, biogrid 96 50 6 6 0
GDI2 GDI2 P50395 Rab GDP dissociation inhibitor beta chr10 Not Cancer Driver No 1 hippie, biogrid 49 23 2 2 0
GID8 GID8 Q9NWU2 Glucose-induced degradation protein 8 homolog chr20 Not Cancer Driver No 1 hippie 30 60 6 6 0
GLG1_ENST00000422840 GLG1 Q92896 Golgi apparatus protein 1 chr16 Not Cancer Driver No 1 intact, hippie 134 103 7 7 0
GLO1 GLO1 Q04760 Lactoylglutathione lyase chr6 Not Cancer Driver No 1 hippie, biogrid 24 46 7 7 0
GLRX3 GLRX3 O76003 Glutaredoxin-3 chr10 Not Cancer Driver No 1 hippie 52 24 4 4 0
GNB2 GNB2 P62879 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 chr7 Not Cancer Driver No 1 intact, hippie, biogrid 50 21 0 0 7
GOT2 GOT2 P00505 Aspartate aminotransferase, mitochondrial chr16 Not Cancer Driver No 1 hippie, biogrid 61 25 3 3 1
GPI_ENST00000644934 GPI P06744 Glucose-6-phosphate isomerase chr19 Not Cancer Driver No 2 intact, hippie, biogrid 77 73 11 11 24
GPX1_ENST00000620890 GPX1 P07203 Glutathione peroxidase 1 chr3 Not Cancer Driver No 1 biogrid 38 12 1 1 0
GRB14 GRB14 Q14449 Growth factor receptor-bound protein 14 chr2 Not Cancer Driver No 1 hippie 83 117 11 11 0
GRM5 GRM5 P41594 Metabotropic glutamate receptor 5 chr11 Not Cancer Driver No 2 intact, hippie 312 323 51 51 0
GRWD1 GRWD1 Q9BQ67 Glutamate-rich WD repeat-containing protein 1 chr19 Not Cancer Driver No 1 hippie 44 187 14 14 0
GSK3A GSK3A P49840 Glycogen synthase kinase-3 alpha chr19 Not Cancer Driver No 1 hippie 55 180 8 8 0
GSK3B_ENST00000264235 GSK3B P49841 Glycogen synthase kinase-3 beta chr3 Not Cancer Driver No 2 intact, hippie 56 146 13 13 0
GSN GSN P06396 Gelsolin chr9 Not Cancer Driver No 1 hippie 76 316 28 28 2
GTF3C5_ENST00000372097 GTF3C5 Q9Y5Q8 General transcription factor 3C polypeptide 5 chr9 Not Cancer Driver No 1 hippie 75 157 21 21 0
HABP4 HABP4 Q5JVS0 Intracellular hyaluronan-binding protein 4 chr9 Not Cancer Driver No 1 hippie 32 413 32 32 0
HADHA HADHA P40939 Trifunctional enzyme subunit alpha, mitochondrial chr2 Not Cancer Driver No 2 intact, hippie, biogrid 72 19 2 2 5
HADHB HADHB P55084 Trifunctional enzyme subunit beta, mitochondrial chr2 Not Cancer Driver No 2 intact, hippie, biogrid 71 41 9 9 14
HDAC6_ENST00000426196 HDAC6 Q9UBN7 Histone deacetylase 6 chrX Not Cancer Driver No 1 hippie 178 409 59 59 0
HINT1 HINT1 P49773 Adenosine 5'-monophosphoramidase HINT1 chr5 Not Cancer Driver No 1 hippie, biogrid 11 6 0 0 6
HMGB1_ENST00000405805 HMGB1 P09429 High mobility group protein B1 chr13 Not Cancer Driver No 1 intact, hippie, biogrid 25 203 20 20 0
HMGB2 HMGB2 P26583 High mobility group protein B2 chr4 Not Cancer Driver No 1 intact, hippie, biogrid 38 207 38 38 0
HNRNPL HNRNPL P14866 Heterogeneous nuclear ribonucleoprotein L chr19 Not Cancer Driver No 1 hippie 89 283 29 29 0
HPRT1 HPRT1 P00492 Hypoxanthine-guanine phosphoribosyltransferase chrX Not Cancer Driver No 1 intact, hippie, biogrid 22 3 0 0 62
HRAS HRAS P01112 GTPase HRas chr11 Census, Compendium Yes 1 hippie 107 16 4 4 18
HSP90AA1_ENST00000216281 HSP90AA1 P07900 Heat shock protein HSP 90-alpha chr14 Census, Compendium Yes 1 intact, hippie 106 257 37 37 0
HSP90AB1 HSP90AB1 P08238 Heat shock protein HSP 90-beta chr6 Census, Compendium Yes 1 intact, hippie 100 254 43 43 0
HSP90B1 HSP90B1 P14625 Endoplasmin chr12 Not Cancer Driver No 1 intact, hippie, biogrid 94 268 35 35 0
HSPA1A HSPA1A P0DMV8 Heat shock 70 kDa protein 1A chr6 Not Cancer Driver No 1 hippie 24 200 13 13 0
HSPA5 HSPA5 P11021 Endoplasmic reticulum chaperone BiP chr9 Not Cancer Driver No 1 hippie 73 282 35 35 0
HSPA6 HSPA6 P17066 Heat shock 70 kDa protein 6 chr1 Not Cancer Driver No 1 intact, hippie 112 235 27 27 0
HSPA8_ENST00000532636 HSPA8 P11142 Heat shock cognate 71 kDa protein chr11 Not Cancer Driver No 1 intact, hippie 149 251 52 52 0
HSPA9 HSPA9 P38646 Stress-70 protein, mitochondrial chr5 Not Cancer Driver No 1 hippie 67 283 26 26 2
HSPB1 HSPB1 P04792 Heat shock protein beta-1 chr7 Not Cancer Driver No 2 intact, hippie 10 118 8 8 20
HSPE1 HSPE1 P61604 10 kDa heat shock protein, mitochondrial chr2 Not Cancer Driver No 1 intact, hippie, biogrid 8 3 0 0 0
HUWE1_ENST00000262854 HUWE1 Q7Z6Z7 E3 ubiquitin-protein ligase HUWE1 chrX Not Cancer Driver No 1 hippie 669 2091 329 329 21
IKBKB IKBKB O14920 Inhibitor of nuclear factor kappa-B kinase subunit beta chr8 Census, Compendium Yes 1 hippie 106 211 31 31 1
IL4R_ENST00000543915 IL4R P24394 Interleukin-4 receptor subunit alpha chr16 Not Cancer Driver No 1 hippie 133 420 64 64 0
IMMT IMMT Q16891 MICOS complex subunit MIC60 chr2 Not Cancer Driver No 1 hippie 97 400 50 50 0
IPO5_ENST00000490680 IPO5 O00410 Importin-5 chr13 Not Cancer Driver No 2 intact, hippie, biogrid 128 52 3 3 0
IRAK1 IRAK1 P51617 Interleukin-1 receptor-associated kinase 1 chrX Compendium Yes 1 hippie 71 337 39 39 0
IRS1 IRS1 P35568 Insulin receptor substrate 1 chr2 Not Cancer Driver No 1 hippie 161 1072 133 133 2
IRS4 IRS4 O14654 Insulin receptor substrate 4 chrX Census, Compendium Yes 1 hippie 297 798 203 203 0
ITSN2 ITSN2 Q9NZM3 Intersectin-2 chr2 Not Cancer Driver No 1 intact, hippie 207 680 92 92 0
JAK1 JAK1 P23458 Tyrosine-protein kinase JAK1 chr1 Census, Compendium Yes 1 hippie 147 120 7 7 2
KBTBD7 KBTBD7 Q8WVZ9 Kelch repeat and BTB domain-containing protein 7 chr13 Not Cancer Driver No 1 hippie, biogrid 92 105 6 6 0
KCTD17 KCTD17 Q8N5Z5 BTB/POZ domain-containing protein KCTD17 chr22 Not Cancer Driver No 1 hippie 23 187 14 14 1
KCTD2 KCTD2 Q14681 BTB/POZ domain-containing protein KCTD2 chr17 Not Cancer Driver No 1 hippie 34 128 11 11 0
KCTD5 KCTD5 Q9NXV2 BTB/POZ domain-containing protein KCTD5 chr16 Not Cancer Driver No 1 hippie 22 32 3 3 0
KEAP1_ENST00000393623 KEAP1 Q14145 Kelch-like ECH-associated protein 1 chr19 Census, Compendium Yes 1 hippie 237 57 12 12 0
KHSRP KHSRP Q92945 Far upstream element-binding protein 2 chr19 Not Cancer Driver No 1 hippie, biogrid 84 684 81 81 0
KIF11 KIF11 P52732 Kinesin-like protein KIF11 chr10 Not Cancer Driver No 1 hippie 90 389 26 26 4
KIF5B KIF5B P33176 Kinesin-1 heavy chain chr10 Census, Compendium Yes 1 intact, hippie, biogrid 122 586 67 67 0
KRT10 KRT10 P13645 Keratin, type I cytoskeletal 10 chr17 Not Cancer Driver No 1 hippie 79 297 38 38 16
LGALS1 LGALS1 P09382 Galectin-1 chr22 Not Cancer Driver No 1 hippie 16 0 0 0 0
LLGL1 LLGL1 Q15334 Lethal(2) giant larvae protein homolog 1 chr17 Not Cancer Driver No 4 hippie, biogrid 101 265 12 12 0
LLGL2 LLGL2 Q6P1M3 LLGL scribble cell polarity complex component 2 chr17 Not Cancer Driver No 5 intact, hippie, biogrid 120 266 26 26 0
LRPPRC LRPPRC P42704 Leucine-rich PPR motif-containing protein, mitochondrial chr2 Not Cancer Driver No 1 hippie, biogrid 131 18 2 2 1
LRRK2 LRRK2 Q5S007 Leucine-rich repeat serine/threonine-protein kinase 2 chr12 Not Cancer Driver No 1 hippie 519 90 17 17 23
MAP1B MAP1B P46821 Microtubule-associated protein 1B chr5 Not Cancer Driver No 1 hippie 332 1947 278 278 0
MAP1LC3B MAP1LC3B Q9GZQ8 Microtubule-associated proteins 1A/1B light chain 3B chr16 Not Cancer Driver No 1 hippie 10 17 1 1 0
MAP2K1 MAP2K1 Q02750 Dual specificity mitogen-activated protein kinase kinase 1 chr15 Census, Compendium Yes 1 hippie 94 96 24 24 6
MAP2K4_ENST00000353533 MAP2K4 P45985 Dual specificity mitogen-activated protein kinase kinase 4 chr17 Census, Compendium Yes 1 hippie, biogrid 89 137 28 28 0
MAP2K5 MAP2K5 Q13163 Dual specificity mitogen-activated protein kinase kinase 5 chr15 Not Cancer Driver No 1 hippie 40 85 10 10 0
MAP3K10 MAP3K10 Q02779 Mitogen-activated protein kinase kinase kinase 10 chr19 Not Cancer Driver No 1 biogrid 112 589 62 62 0
MAPK15 MAPK15 Q8TD08 Mitogen-activated protein kinase 15 chr8 Not Cancer Driver No 1 hippie, biogrid 81 235 37 37 0
MAPK1_ENST00000398822 MAPK1 P28482 Mitogen-activated protein kinase 1 chr22 Census, Compendium Yes 1 hippie 62 2 0 0 7
MAPK3 MAPK3 P27361 Mitogen-activated protein kinase 3 chr16 Not Cancer Driver No 1 hippie 38 49 5 5 0
MAPK7 MAPK7 Q13164 Mitogen-activated protein kinase 7 chr17 Not Cancer Driver No 1 hippie 92 490 50 50 0
MAPT_ENST00000262410 MAPT P10636 Microtubule-associated protein tau chr17 Not Cancer Driver No 1 hippie 128 750 126 126 18
MARCKS MARCKS P29966 Myristoylated alanine-rich C-kinase substrate chr6 Not Cancer Driver No 2 hippie, biogrid 14 328 14 14 0
MARCKSL1 MARCKSL1 P49006 MARCKS-related protein chr1 Not Cancer Driver No 1 intact, hippie, biogrid 28 195 28 28 0
MBP_ENST00000580402 MBP P02686 Myelin basic protein chr18 Not Cancer Driver No 1 hippie 52 304 52 52 0
MDH1_ENST00000233114 MDH1 P40925 Malate dehydrogenase, cytoplasmic chr2 Not Cancer Driver No 1 hippie, biogrid 41 18 2 2 1
MDH2 MDH2 P40926 Malate dehydrogenase, mitochondrial chr7 Not Cancer Driver No 1 intact, hippie, biogrid 39 8 1 1 3
MLKL MLKL Q8NB16 Mixed lineage kinase domain-like protein chr16 Not Cancer Driver No 1 intact, hippie, biogrid 56 89 15 15 0
MMP25 MMP25 Q9NPA2 Matrix metalloproteinase-25 chr16 Not Cancer Driver No 1 biogrid 54 243 20 20 0
MRPL1 MRPL1 Q9BYD6 39S ribosomal protein L1, mitochondrial chr4 Not Cancer Driver No 1 hippie 44 46 5 5 0
MRPL12 MRPL12 P52815 39S ribosomal protein L12, mitochondrial chr17 Not Cancer Driver No 2 intact, hippie 21 22 6 6 1
MRPL18 MRPL18 Q9H0U6 39S ribosomal protein L18, mitochondrial chr6 Not Cancer Driver No 1 hippie 26 35 2 2 0
MRPL19_ENST00000409374 MRPL19 P49406 39S ribosomal protein L19, mitochondrial chr2 Not Cancer Driver No 1 hippie 22 63 4 4 0
MRPL37_ENST00000360840 MRPL37 Q9BZE1 39S ribosomal protein L37, mitochondrial chr1 Not Cancer Driver No 1 hippie 44 36 5 5 0
MRPL38 MRPL38 Q96DV4 39S ribosomal protein L38, mitochondrial chr17 Not Cancer Driver No 1 hippie 41 88 13 13 0
MRPL39_ENST00000352957 MRPL39 Q9NYK5 39S ribosomal protein L39, mitochondrial chr21 Not Cancer Driver No 1 hippie 41 38 6 6 0
MRPL46 MRPL46 Q9H2W6 39S ribosomal protein L46, mitochondrial chr15 Not Cancer Driver No 1 hippie 24 58 0 0 0
MRPL48 MRPL48 Q96GC5 39S ribosomal protein L48, mitochondrial chr11 Not Cancer Driver No 1 hippie 16 15 1 1 0
MRPL49 MRPL49 Q13405 39S ribosomal protein L49, mitochondrial chr11 Not Cancer Driver No 1 hippie 17 74 9 9 0
MRPL50 MRPL50 Q8N5N7 39S ribosomal protein L50, mitochondrial chr9 Not Cancer Driver No 1 hippie 27 3 0 0 0
MRPL52 MRPL52 Q86TS9 39S ribosomal protein L52, mitochondrial chr14 Not Cancer Driver No 1 hippie 11 75 7 7 0
MRPL53 MRPL53 Q96EL3 39S ribosomal protein L53, mitochondrial chr2 Not Cancer Driver No 2 intact, hippie 20 22 1 1 0
MRPL54 MRPL54 Q6P161 39S ribosomal protein L54, mitochondrial chr19 Not Cancer Driver No 1 hippie 25 53 4 4 0
MRPL55_ENST00000366746 MRPL55 Q7Z7F7 39S ribosomal protein L55, mitochondrial chr1 Not Cancer Driver No 1 hippie 19 67 13 13 0
MRPS2 MRPS2 Q9Y399 28S ribosomal protein S2, mitochondrial chr9 Not Cancer Driver No 1 intact, hippie 32 57 6 6 3
MSH2 MSH2 P43246 DNA mismatch repair protein Msh2 chr2 Census Yes 1 hippie 92 37 4 4 70
MSH6 MSH6 P52701 DNA mismatch repair protein Msh6 chr2 Census Yes 1 hippie 154 386 41 41 6
MTHFD1 MTHFD1 P11586 C-1-tetrahydrofolate synthase, cytoplasmic chr14 Not Cancer Driver No 1 intact, hippie, biogrid 103 129 11 11 6
MYCBP MYCBP Q99417 c-Myc-binding protein chr1 Not Cancer Driver No 1 hippie 8 54 4 4 0
NAP1L1 NAP1L1 P55209 Nucleosome assembly protein 1-like 1 chr12 Not Cancer Driver No 2 intact, hippie 47 207 31 31 0
NAP1L4 NAP1L4 Q99733 Nucleosome assembly protein 1-like 4 chr11 Not Cancer Driver No 1 intact, hippie 38 194 19 19 0
NASP NASP P49321 Nuclear autoantigenic sperm protein chr1 Not Cancer Driver No 1 intact, hippie, biogrid 95 615 81 81 0
NCF1 NCF1 P14598 Neutrophil cytosol factor 1 chr7 Not Cancer Driver No 2 intact, hippie 37 181 12 12 1
NCL NCL P19338 Nucleolin chr2 Not Cancer Driver No 1 hippie 85 569 68 68 0
NCOA3 NCOA3 Q9Y6Q9 Nuclear receptor coactivator 3 chr20 Not Cancer Driver No 1 hippie 176 1231 160 160 0
NEDD8 NEDD8 Q15843 NEDD8 chr14 Not Cancer Driver No 1 hippie 10 36 5 5 0
NFATC2 NFATC2 Q13469 Nuclear factor of activated T-cells, cytoplasmic 2 chr20 Census, Compendium Yes 1 hippie 194 722 162 162 0
NIPSNAP1 NIPSNAP1 Q9BPW8 Protein NipSnap homolog 1 chr22 Not Cancer Driver No 2 intact, hippie 31 9 0 0 0
NIPSNAP2 NIPSNAP2 O75323 Protein NipSnap homolog 2 chr7 Not Cancer Driver No 3 intact, hippie 30 6 1 1 0
NMT2 NMT2 O60551 Glycylpeptide N-tetradecanoyltransferase 2 chr10 Not Cancer Driver No 1 intact, hippie 60 154 20 20 0
NOC2L NOC2L Q9Y3T9 Nucleolar complex protein 2 homolog chr1 Not Cancer Driver No 1 hippie 77 281 31 31 0
NPM1 NPM1 P06748 Nucleophosmin chr5 Census, Compendium Yes 2 intact, hippie 29 249 22 22 0
NPM3 NPM3 O75607 Nucleoplasmin-3 chr10 Not Cancer Driver No 2 intact, hippie 23 78 11 11 0
NR5A1 NR5A1 Q13285 Steroidogenic factor 1 chr9 Not Cancer Driver No 1 biogrid 60 133 29 29 24
NSRP1 NSRP1 Q9H0G5 Nuclear speckle splicing regulatory protein 1 chr17 Not Cancer Driver No 1 hippie 61 521 56 56 0
NUMB_ENST00000355058 NUMB P49757 Protein numb homolog chr14 Not Cancer Driver No 1 hippie 70 490 58 58 0
OAT OAT P04181 Ornithine aminotransferase, mitochondrial chr10 Not Cancer Driver No 1 hippie, biogrid 52 17 0 0 27
OLA1 OLA1 Q9NTK5 Obg-like ATPase 1 chr2 Not Cancer Driver No 1 hippie, biogrid 41 40 5 5 0
P4HB P4HB P07237 Protein disulfide-isomerase chr17 Not Cancer Driver No 1 intact, hippie, biogrid 61 79 15 15 1
PA2G4 PA2G4 Q9UQ80 Proliferation-associated protein 2G4 chr12 Not Cancer Driver No 1 intact, hippie, biogrid 45 128 18 18 0
PAICS_ENST00000512576 PAICS P22234 Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase chr4 Not Cancer Driver No 1 intact, hippie, biogrid 23 35 3 3 0
PAK1_ENST00000356341 PAK1 Q13153 Serine/threonine-protein kinase PAK 1 chr11 Not Cancer Driver No 1 hippie 57 299 30 30 2
PARD3 PARD3 Q8TEW0 Partitioning defective 3 homolog chr10 Not Cancer Driver No 2 intact, hippie 200 1144 170 170 2
PARD6A PARD6A Q9NPB6 Partitioning defective 6 homolog alpha chr16 Not Cancer Driver No 8 intact, hippie, biogrid 25 177 13 13 0
PARD6B PARD6B Q9BYG5 Partitioning defective 6 homolog beta chr20 Not Cancer Driver No 10 intact, hippie, biogrid 50 166 23 23 0
PARD6G PARD6G Q9BYG4 Partitioning defective 6 homolog gamma chr18 Not Cancer Driver No 8 intact, hippie, biogrid 32 175 11 11 0
PARK7_ENST00000377488 PARK7 Q99497 Parkinson disease protein 7 chr1 Not Cancer Driver No 1 intact, hippie, biogrid 11 30 0 0 5
PAWR PAWR Q96IZ0 PRKC apoptosis WT1 regulator protein chr12 Not Cancer Driver No 1 hippie 35 327 33 33 0
PCNA PCNA P12004 Proliferating cell nuclear antigen chr20 Not Cancer Driver No 1 intact, hippie, biogrid 30 22 3 3 1
PDCD5 PDCD5 O14737 Programmed cell death protein 5 chr19 Not Cancer Driver No 1 hippie, biogrid 15 91 7 7 0
PDIA3 PDIA3 P30101 Protein disulfide-isomerase A3 chr15 Not Cancer Driver No 1 hippie, biogrid 57 98 11 11 0
PDIA4 PDIA4 P13667 Protein disulfide-isomerase A4 chr7 Not Cancer Driver No 1 hippie, biogrid 81 147 22 22 0
PDIA6_ENST00000272227 PDIA6 Q15084 Protein disulfide-isomerase A6 chr2 Not Cancer Driver No 1 intact, hippie, biogrid 55 82 11 11 0
PDLIM7 PDLIM7 Q9NR12 PDZ and LIM domain protein 7 chr5 Not Cancer Driver No 1 hippie 48 244 20 20 0
PDPK1 PDPK1 O15530 3-phosphoinositide-dependent protein kinase 1 chr16 Not Cancer Driver No 1 hippie 33 121 12 12 0
PEBP1 PEBP1 P30086 Phosphatidylethanolamine-binding protein 1 chr12 Not Cancer Driver No 2 hippie, biogrid 23 76 13 13 0
PFKP PFKP Q01813 ATP-dependent 6-phosphofructokinase, platelet type chr10 Not Cancer Driver No 1 intact, hippie, biogrid 133 43 10 10 0
PFN1 PFN1 P07737 Profilin-1 chr17 Not Cancer Driver No 1 hippie, biogrid 16 7 1 1 3
PGD PGD P52209 6-phosphogluconate dehydrogenase, decarboxylating chr1 Not Cancer Driver No 1 intact, hippie, biogrid 73 19 3 3 0
PGK1 PGK1 P00558 Phosphoglycerate kinase 1 chrX Not Cancer Driver No 1 hippie, biogrid 61 40 5 5 9
PGRMC1 PGRMC1 O00264 Membrane-associated progesterone receptor component 1 chrX Not Cancer Driver No 1 hippie, biogrid 30 74 16 16 0
PIAS4 PIAS4 Q8N2W9 E3 SUMO-protein ligase PIAS4 chr19 Not Cancer Driver No 1 hippie 58 142 23 23 0
PKD1 PKD1 P98161 Polycystin-1 chr16 Not Cancer Driver No 1 intact, hippie 393 690 66 66 92
PLEKHA4 PLEKHA4 Q9H4M7 Pleckstrin homology domain-containing family A member 4 chr19 Not Cancer Driver No 1 hippie 136 687 128 128 0
POLD1_ENST00000440232 POLD1 P28340 DNA polymerase delta catalytic subunit chr19 Census, Compendium Yes 1 hippie 179 214 31 31 2
POLRMT POLRMT O00411 DNA-directed RNA polymerase, mitochondrial chr19 Not Cancer Driver No 1 intact, hippie 188 253 31 31 0
PPA1 PPA1 Q15181 Inorganic pyrophosphatase chr10 Not Cancer Driver No 1 hippie, biogrid 31 24 0 0 0
PPFIBP1 PPFIBP1 Q86W92 Liprin-beta-1 chr12 Census Yes 1 hippie 110 555 57 57 0
PPIA PPIA P62937 Peptidyl-prolyl cis-trans isomerase A chr7 Not Cancer Driver No 1 hippie 11 24 3 3 0
PPIF PPIF P30405 Peptidyl-prolyl cis-trans isomerase F, mitochondrial chr10 Not Cancer Driver No 1 intact, hippie, biogrid 19 43 4 4 0
PPIL4 PPIL4 Q8WUA2 Peptidyl-prolyl cis-trans isomerase-like 4 chr6 Not Cancer Driver No 1 hippie 62 237 34 34 0
PPP1CC_ENST00000335007 PPP1CC P36873 Serine/threonine-protein phosphatase PP1-gamma catalytic subunit chr12 Not Cancer Driver No 1 hippie 26 23 4 4 0
PPP1R14A PPP1R14A Q96A00 Protein phosphatase 1 regulatory subunit 14A chr19 Not Cancer Driver No 1 hippie 14 113 10 10 0
PPP2CA PPP2CA P67775 Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform chr5 Not Cancer Driver No 1 hippie 41 12 1 1 8
PPP3CA PPP3CA Q08209 Protein phosphatase 3 catalytic subunit alpha chr4 Compendium Yes 1 hippie 85 140 27 27 7
PRDX1_ENST00000319248 PRDX1 Q06830 Peroxiredoxin-1 chr1 Not Cancer Driver No 1 hippie 22 40 5 5 0
PRDX3 PRDX3 P30048 Thioredoxin-dependent peroxide reductase, mitochondrial chr10 Not Cancer Driver No 1 hippie, biogrid 23 23 3 3 0
PRDX4 PRDX4 Q13162 Peroxiredoxin-4 chrX Not Cancer Driver No 2 intact, hippie, biogrid 36 29 2 2 0
PRDX6 PRDX6 P30041 Peroxiredoxin-6 chr1 Not Cancer Driver No 1 intact, hippie, biogrid 46 13 4 4 0
PRG2 PRG2 P13727 Bone marrow proteoglycan chr11 Not Cancer Driver No 1 hippie 45 65 15 15 0
PRKACA PRKACA P17612 cAMP-dependent protein kinase catalytic subunit alpha chr19 Census Yes 1 intact, hippie 53 24 0 0 2
PRKACB_ENST00000370689 PRKACB P22694 cAMP-dependent protein kinase catalytic subunit beta chr1 Not Cancer Driver No 1 intact, hippie 50 26 6 6 4
PRKAR1A_ENST00000536854 PRKAR1A P10644 cAMP-dependent protein kinase type I-alpha regulatory subunit chr17 Census, Compendium Yes 1 hippie 39 66 11 11 17
PRKCA PRKCA P17252 Protein kinase C alpha type chr17 Not Cancer Driver No 1 hippie 94 154 22 22 0
PRKCD_ENST00000330452 PRKCD Q05655 Protein kinase C delta type chr3 Compendium Yes 1 hippie 79 43 9 9 0
PRKCI PRKCI P41743 Protein kinase C iota type chr3 Not Cancer Driver No 4 hippie, biogrid 110 120 16 16 0
PRKCQ PRKCQ Q04759 Protein kinase C theta type chr10 Not Cancer Driver No 1 intact, hippie 147 28 9 9 0
PRKCSH_ENST00000589838 PRKCSH P14314 Glucosidase 2 subunit beta chr19 Not Cancer Driver No 1 hippie, biogrid 68 320 41 41 0
PRKCZ PRKCZ Q05513 Protein kinase C zeta type chr1 Not Cancer Driver No 1 hippie 70 116 11 11 0
PRKD1_ENST00000616995 PRKD1 Q15139 Serine/threonine-protein kinase D1 chr14 Census Yes 1 hippie 201 189 33 33 2
PRPSAP2 PRPSAP2 O60256 Phosphoribosyl pyrophosphate synthase-associated protein 2 chr17 Not Cancer Driver No 1 hippie 54 19 3 3 0
PSEN1 PSEN1 P49768 Presenilin-1 chr14 Not Cancer Driver No 1 hippie 61 134 21 21 96
PSMC4 PSMC4 P43686 26S proteasome regulatory subunit 6B chr19 Not Cancer Driver No 1 hippie 51 21 3 3 0
PSMC5 PSMC5 P62195 26S proteasome regulatory subunit 8 chr17 Not Cancer Driver No 1 hippie 52 64 6 6 0
PSMD1 PSMD1 Q99460 26S proteasome non-ATPase regulatory subunit 1 chr2 Not Cancer Driver No 1 hippie 110 201 19 19 0
PSME3_ENST00000590720 PSME3 P61289 Proteasome activator complex subunit 3 chr17 Not Cancer Driver No 2 intact, hippie, biogrid 20 25 5 5 0
PTGES3_ENST00000262033 PTGES3 Q15185 Prostaglandin E synthase 3 chr12 Not Cancer Driver No 1 hippie, biogrid 11 52 3 3 0
PTPN14 PTPN14 Q15678 Tyrosine-protein phosphatase non-receptor type 14 chr1 Compendium Yes 1 hippie 173 582 99 99 0
PTPRZ1 PTPRZ1 P23471 Receptor-type tyrosine-protein phosphatase zeta chr7 Not Cancer Driver No 1 biogrid 480 978 216 216 0
RACK1 RACK1 P63244 Receptor of activated protein C kinase 1 chr5 Not Cancer Driver No 1 hippie 34 13 0 0 0
RAF1 RAF1 P04049 RAF proto-oncogene serine/threonine-protein kinase chr3 Census, Compendium Yes 1 hippie 89 169 38 38 22
RALGDS RALGDS Q12967 Ral guanine nucleotide dissociation stimulator chr9 Census, Compendium Yes 1 hippie 104 379 44 44 0
RCN2_ENST00000394885 RCN2 Q14257 Reticulocalbin-2 chr15 Not Cancer Driver No 1 intact, hippie 35 125 11 11 0
RELA RELA Q04206 Transcription factor p65 chr11 Compendium Yes 1 hippie 75 400 48 48 0
RHOA RHOA P61586 Transforming protein RhoA chr3 Census, Compendium Yes 2 hippie, biogrid 99 46 13 13 2
RICTOR_ENST00000357387 RICTOR Q6R327 Rapamycin-insensitive companion of mTOR chr5 Not Cancer Driver No 1 intact, hippie 212 366 50 50 0
RIPK1_ENST00000380409 RIPK1 Q13546 Receptor-interacting serine/threonine-protein kinase 1 chr6 Compendium Yes 1 hippie 82 277 39 39 4
RNF146 RNF146 Q9NTX7 E3 ubiquitin-protein ligase RNF146 chr6 Not Cancer Driver No 1 hippie 37 206 24 24 0
RNH1_ENST00000397604 RNH1 P13489 Ribonuclease inhibitor chr11 Not Cancer Driver No 1 hippie 40 0 0 0 0
RPLP1 RPLP1 P05386 60S acidic ribosomal protein P1 chr15 Not Cancer Driver No 1 hippie 6 45 2 2 0
RPN2 RPN2 P04844 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 chr20 Not Cancer Driver No 1 hippie, biogrid 53 26 4 4 0
RPS12 RPS12 P25398 40S ribosomal protein S12 chr6 Not Cancer Driver No 1 hippie 17 0 0 0 0
RPS6KB1 RPS6KB1 P23443 Ribosomal protein S6 kinase beta-1 chr17 Not Cancer Driver No 1 hippie 45 226 26 26 0
RPUSD4 RPUSD4 Q96CM3 Pseudouridylate synthase RPUSD4, mitochondrial chr11 Not Cancer Driver No 1 intact, hippie 54 97 15 15 0
SDHA SDHA P31040 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial chr5 Census Yes 1 intact, hippie, biogrid 115 71 13 13 7
SEC61B SEC61B P60468 Protein transport protein Sec61 subunit beta chr9 Not Cancer Driver No 1 intact, hippie, biogrid 11 60 7 7 0
SHMT2 SHMT2 P34897 Serine hydroxymethyltransferase, mitochondrial chr12 Not Cancer Driver No 1 intact, hippie, biogrid 57 58 5 5 1
SLC16A1 SLC16A1 P53985 Monocarboxylate transporter 1 chr1 Not Cancer Driver No 1 hippie, biogrid 69 70 3 3 3
SLC1A5 SLC1A5 Q15758 Neutral amino acid transporter B(0) chr19 Not Cancer Driver No 1 hippie, biogrid 52 61 7 7 0
SLC25A1 SLC25A1 P53007 Tricarboxylate transport protein, mitochondrial chr22 Not Cancer Driver No 1 intact, hippie, biogrid 22 34 2 2 17
SLC25A3 SLC25A3 Q00325 Phosphate carrier protein, mitochondrial chr12 Not Cancer Driver No 2 intact, hippie 49 32 4 4 1
SLC25A4 SLC25A4 P12235 ADP/ATP translocase 1 chr4 Not Cancer Driver No 1 intact, hippie 24 0 0 0 9
SLC25A5 SLC25A5 P05141 ADP/ATP translocase 2 chrX Not Cancer Driver No 2 intact, hippie 41 0 0 0 0
SLC25A6 SLC25A6 P12236 ADP/ATP translocase 3 chrX Not Cancer Driver No 1 intact, hippie 41 0 0 0 0
SLC35G1 SLC35G1 Q2M3R5 Solute carrier family 35 member G1 chr10 Not Cancer Driver No 1 intact, hippie 37 36 0 0 0
SLC39A1_ENST00000310483 SLC39A1 Q9NY26 Zinc transporter ZIP1 chr1 Not Cancer Driver No 1 hippie 38 22 0 0 0
SLFN11_ENST00000308377 SLFN11 Q7Z7L1 Schlafen family member 11 chr17 Not Cancer Driver No 1 hippie 177 34 8 8 0
SND1 SND1 Q7KZF4 Staphylococcal nuclease domain-containing protein 1 chr7 Census Yes 1 hippie, biogrid 127 258 48 48 0
SNRPD1 SNRPD1 P62314 Small nuclear ribonucleoprotein Sm D1 chr18 Not Cancer Driver No 1 hippie 10 80 4 4 0
SNRPD2_ENST00000588301 SNRPD2 P62316 Small nuclear ribonucleoprotein Sm D2 chr19 Not Cancer Driver No 1 hippie 19 67 12 12 0
SOD1 SOD1 P00441 Superoxide dismutase [Cu-Zn] chr21 Not Cancer Driver No 1 hippie, biogrid 16 93 9 9 79
SP1 SP1 P08047 Transcription factor Sp1 chr12 Not Cancer Driver No 1 hippie 96 599 71 71 0
SQSTM1 SQSTM1 Q13501 Sequestosome-1 chr5 Not Cancer Driver No 7 intact, hippie, biogrid 54 267 32 32 30
SRC_ENST00000358208 SRC P12931 Proto-oncogene tyrosine-protein kinase Src chr20 Census Yes 2 hippie, biogrid 53 130 11 11 1
STAT6_ENST00000543873 STAT6 P42226 Signal transducer and activator of transcription 6 chr12 Census, Compendium Yes 1 hippie 106 325 44 44 0
STK24 STK24 Q9Y6E0 Serine/threonine-protein kinase 24 chr13 Not Cancer Driver No 1 intact, hippie, biogrid 67 118 16 16 0
STK38 STK38 Q15208 Serine/threonine-protein kinase 38 chr6 Not Cancer Driver No 1 hippie 57 77 6 6 0
STT3A_ENST00000529196 STT3A P46977 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A chr11 Not Cancer Driver No 1 hippie, biogrid 82 27 2 2 1
STUB1 STUB1 Q9UNE7 E3 ubiquitin-protein ligase CHIP chr16 Not Cancer Driver No 1 hippie 35 112 14 14 12
SUB1_ENST00000515355 SUB1 P53999 Activated RNA polymerase II transcriptional coactivator p15 chr5 Not Cancer Driver No 1 hippie, biogrid 13 108 6 6 0
SUMO2 SUMO2 P61956 Small ubiquitin-related modifier 2 chr17 Not Cancer Driver No 1 hippie, biogrid 9 69 6 6 0
TAB1 TAB1 Q15750 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 chr22 Not Cancer Driver No 1 hippie 81 232 34 34 0
TARS_ENST00000265112 TARS1 P26639 Threonine--tRNA ligase 1, cytoplasmic chr5 Not Cancer Driver No 1 intact 112 112 22 22 2
TBCB TBCB Q99426 Tubulin-folding cofactor B chr19 Not Cancer Driver No 1 hippie, biogrid 30 59 2 2 0
TECR TECR Q9NZ01 Very-long-chain enoyl-CoA reductase chr19 Not Cancer Driver No 1 intact, hippie, biogrid 41 0 0 0 1
TIAM1 TIAM1 Q13009 Rho guanine nucleotide exchange factor TIAM1 chr21 Not Cancer Driver No 1 hippie 370 810 194 194 0
TIMM50_ENST00000607714 TIMM50 Q3ZCQ8 Mitochondrial import inner membrane translocase subunit TIM50 chr19 Not Cancer Driver No 1 intact, hippie 39 75 7 7 0
TKT_ENST00000462138 TKT P29401 Transketolase chr3 Not Cancer Driver No 1 intact, hippie, biogrid 66 86 7 7 1
TLR4_ENST00000355622 TLR4 O00206 Toll-like receptor 4 chr9 Not Cancer Driver No 1 hippie 292 0 0 0 0
TLR9 TLR9 Q9NR96 Toll-like receptor 9 chr3 Not Cancer Driver No 1 hippie 141 35 3 3 0
TMEM160 TMEM160 Q9NX00 Transmembrane protein 160 chr19 Not Cancer Driver No 1 hippie, biogrid 8 46 1 1 0
TPR TPR P12270 Nucleoprotein TPR chr1 Census Yes 1 hippie 311 1990 266 266 0
TRAF6_ENST00000348124 TRAF6 Q9Y4K3 TNF receptor-associated factor 6 chr11 Not Cancer Driver No 1 hippie 67 62 7 7 0
TRAP1 TRAP1 Q12931 Heat shock protein 75 kDa, mitochondrial chr16 Not Cancer Driver No 1 intact, hippie, biogrid 74 110 11 11 0
TRIM21 TRIM21 P19474 E3 ubiquitin-protein ligase TRIM21 chr11 Not Cancer Driver No 1 hippie 85 49 7 7 0
TRIM26 TRIM26 Q12899 Tripartite motif-containing protein 26 chr6 Not Cancer Driver No 1 intact, hippie 67 153 16 16 0
TRIM28 TRIM28 Q13263 Transcription intermediary factor 1-beta chr19 Not Cancer Driver No 1 intact, hippie 87 430 41 41 0
TRIM41 TRIM41 Q8WV44 E3 ubiquitin-protein ligase TRIM41 chr5 Not Cancer Driver No 3 intact, hippie, biogrid 69 385 38 38 0
TUBA1C_ENST00000301072 TUBA1C Q9BQE3 Tubulin alpha-1C chain chr12 Not Cancer Driver No 1 hippie 39 50 5 5 0
TUBA4A TUBA4A P68366 Tubulin alpha-4A chain chr2 Not Cancer Driver No 1 hippie 73 39 4 4 5
TUBB TUBB P07437 Tubulin beta chain chr6 Not Cancer Driver No 1 intact, hippie 40 63 11 11 5
TUBB3 TUBB3 Q13509 Tubulin beta-3 chain chr16 Not Cancer Driver No 1 hippie 67 53 10 10 12
TUBB4A TUBB4A P04350 Tubulin beta-4A chain chr19 Not Cancer Driver No 1 hippie 91 61 16 16 2
TUBB4B TUBB4B P68371 Tubulin beta-4B chain chr9 Not Cancer Driver No 1 intact, hippie 52 65 11 11 2
TUBB6 TUBB6 Q9BUF5 Tubulin beta-6 chain chr18 Not Cancer Driver No 2 intact, hippie 69 51 5 5 1
TUFM TUFM P49411 Elongation factor Tu, mitochondrial chr16 Not Cancer Driver No 1 intact, hippie, biogrid 51 50 3 3 1
TXNDC5 TXNDC5 Q8NBS9 Thioredoxin domain-containing protein 5 chr6 Not Cancer Driver No 1 intact, hippie, biogrid 47 104 12 12 0
UBA1 UBA1 P22314 Ubiquitin-like modifier-activating enzyme 1 chrX Not Cancer Driver No 1 hippie, biogrid 117 165 22 22 6
UBA2 UBA2 Q9UBT2 SUMO-activating enzyme subunit 2 chr19 Not Cancer Driver No 1 hippie, biogrid 84 219 33 33 0
UBE2O UBE2O Q9C0C9 (E3-independent) E2 ubiquitin-conjugating enzyme chr17 Not Cancer Driver No 1 intact, hippie 129 716 68 68 0
UCHL1 UCHL1 P09936 Ubiquitin carboxyl-terminal hydrolase isozyme L1 chr4 Not Cancer Driver No 1 hippie, biogrid 33 34 7 7 4
UQCRC1 UQCRC1 P31930 Cytochrome b-c1 complex subunit 1, mitochondrial chr3 Not Cancer Driver No 1 hippie, biogrid 57 55 6 6 2
UQCRC2 UQCRC2 P22695 Cytochrome b-c1 complex subunit 2, mitochondrial chr16 Not Cancer Driver No 1 hippie, biogrid 53 48 13 13 1
USP20_ENST00000358355 USP20 Q9Y2K6 Ubiquitin carboxyl-terminal hydrolase 20 chr9 Not Cancer Driver No 1 hippie 112 295 36 36 0
UTP14A UTP14A Q9BVJ6 U3 small nucleolar RNA-associated protein 14 homolog A chrX Not Cancer Driver No 1 hippie 105 629 89 89 0
VCP VCP P55072 Transitional endoplasmic reticulum ATPase chr9 Not Cancer Driver No 1 hippie 88 186 16 16 16
VDAC1_ENST00000395047 VDAC1 P21796 Voltage-dependent anion-selective channel protein 1 chr5 Not Cancer Driver No 1 intact, hippie, biogrid 38 36 4 4 0
VDAC2_ENST00000543351 VDAC2 P45880 Voltage-dependent anion-selective channel protein 2 chr10 Not Cancer Driver No 1 intact, hippie, biogrid 35 9 1 1 0
VHL VHL P40337 von Hippel-Lindau disease tumor suppressor chr3 Census, Compendium Yes 1 intact, hippie 142 117 36 36 133
WDR26 WDR26 Q9H7D7 WD repeat-containing protein 26 chr1 Not Cancer Driver No 1 hippie 71 187 9 9 0
WWC1_ENST00000265293 WWC1 Q8IX03 Protein KIBRA chr5 Not Cancer Driver No 3 intact, hippie, biogrid 147 550 81 81 0
XPO1_ENST00000406957 XPO1 O14980 Exportin-1 chr2 Census, Compendium Yes 1 hippie, biogrid 140 33 9 9 0
YWHAB_ENST00000353703 YWHAB P31946 14-3-3 protein beta/alpha chr20 Not Cancer Driver No 2 intact, hippie 22 109 4 4 0
YWHAG YWHAG P61981 14-3-3 protein gamma chr7 Not Cancer Driver No 1 hippie 26 77 9 9 2
YWHAH YWHAH Q04917 14-3-3 protein eta chr22 Not Cancer Driver No 1 hippie 15 55 3 3 0
YWHAQ YWHAQ P27348 14-3-3 protein theta chr2 Not Cancer Driver No 1 hippie 29 41 6 6 0
YWHAZ_ENST00000395956 YWHAZ P63104 14-3-3 protein zeta/delta chr8 Not Cancer Driver No 1 hippie 30 81 10 10 0
ZNF71 ZNF71 Q9NQZ8 Endothelial zinc finger protein induced by tumor necrosis factor alpha chr19 Not Cancer Driver No 1 intact, hippie 116 179 40 40 0