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PNKD ,PNKD ,Q8N490
  • Uniprot Accession= Q8N490
  • Ensembl Transcript= ENST00000273077.8
  • Uniprot Name= PNKD
  • Name= Probable hydrolase PNKD
  • Chromosome= chr2
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 58
  • Number of Interaction partner in biogrid: 96
  • Number of Interaction partner in hippie: 132
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ACADM_ENST00000370841 ACADM P11310 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial chr1 Not Cancer Driver No 1 hippie 61 41 5 5 19
ADD1_ENST00000398129 ADD1 P35611 Alpha-adducin chr4 Not Cancer Driver No 1 hippie, biogrid 106 439 64 64 0
ADD2_ENST00000407644 ADD2 P35612 Beta-adducin chr2 Not Cancer Driver No 1 hippie, biogrid 157 423 104 104 0
ALDH3B2 ALDH3B2 P48448 Aldehyde dehydrogenase family 3 member B2 chr11 Not Cancer Driver No 1 hippie, biogrid 71 17 4 4 0
AP1B1 AP1B1 Q10567 AP-1 complex subunit beta-1 chr22 Not Cancer Driver No 2 intact, hippie, biogrid 114 119 10 10 1
APP APP P05067 Amyloid-beta precursor protein chr21 Not Cancer Driver No 1 hippie 128 418 71 71 17
ARFGEF3 ARFGEF3 Q5TH69 Brefeldin A-inhibited guanine nucleotide-exchange protein 3 chr6 Not Cancer Driver No 2 intact, hippie 258 584 58 58 0
ARL14EP ARL14EP Q8N8R7 ARL14 effector protein chr11 Not Cancer Driver No 2 intact, hippie, biogrid 30 66 4 4 0
ARL2BP ARL2BP Q9Y2Y0 ADP-ribosylation factor-like protein 2-binding protein chr16 Not Cancer Driver No 2 intact, hippie, biogrid 16 5 0 0 1
ARMC6 ARMC6 Q6NXE6 Armadillo repeat-containing protein 6 chr19 Not Cancer Driver No 1 intact, hippie 65 77 5 5 0
ARMCX3_ENST00000537169 ARMCX3 Q9UH62 Armadillo repeat-containing X-linked protein 3 chrX Not Cancer Driver No 2 hippie, biogrid 39 77 7 7 0
ASAH1_ENST00000262097 ASAH1 Q13510 Acid ceramidase chr8 Not Cancer Driver No 2 intact, hippie, biogrid 47 10 3 3 14
ATRIP ATRIP Q8WXE1 ATR-interacting protein chr3 Not Cancer Driver No 2 intact, hippie, biogrid 76 383 32 32 0
BTAF1 BTAF1 O14981 TATA-binding protein-associated factor 172 chr10 Not Cancer Driver No 1 hippie, biogrid 215 360 52 52 0
CAMK1 CAMK1 Q14012 Calcium/calmodulin-dependent protein kinase type 1 chr3 Not Cancer Driver No 3 intact, hippie, biogrid 40 31 1 1 0
CCNF CCNF P41002 Cyclin-F chr16 Not Cancer Driver No 1 hippie, biogrid 106 221 23 23 3
CETN3_ENST00000283122 CETN3 O15182 Centrin-3 chr5 Not Cancer Driver No 2 intact, hippie, biogrid 13 19 1 1 0
CIP2A CIP2A Q8TCG1 Protein CIP2A chr3 Not Cancer Driver No 2 intact, hippie 118 240 31 31 0
COA3 COA3 Q9Y2R0 Cytochrome c oxidase assembly factor 3 homolog, mitochondrial chr17 Not Cancer Driver No 1 hippie 4 57 3 3 0
DCAF11 DCAF11 Q8TEB1 DDB1- and CUL4-associated factor 11 chr14 Not Cancer Driver No 2 intact, hippie, biogrid 89 149 25 25 0
DCAF7 DCAF7 P61962 DDB1- and CUL4-associated factor 7 chr17 Not Cancer Driver No 1 hippie, biogrid 48 0 0 0 0
DCUN1D5 DCUN1D5 Q9BTE7 DCN1-like protein 5 chr11 Not Cancer Driver No 2 intact, hippie, biogrid 18 7 0 0 0
DDX39A DDX39A O00148 ATP-dependent RNA helicase DDX39A chr19 Not Cancer Driver No 1 hippie, biogrid 44 37 2 2 0
DIAPH3 DIAPH3 Q9NSV4 Protein diaphanous homolog 3 chr13 Not Cancer Driver No 2 hippie, biogrid 189 492 78 78 0
DICER1 DICER1 Q9UPY3 Endoribonuclease Dicer chr14 Census, Compendium Yes 2 intact, hippie, biogrid 264 362 45 45 4
DYM DYM Q7RTS9 Dymeclin chr18 Not Cancer Driver No 2 intact, hippie, biogrid 78 21 0 0 3
ECD_ENST00000372979 ECD O95905 Protein ecdysoneless homolog chr10 Not Cancer Driver No 2 hippie, biogrid 68 254 26 26 0
EGLN3 EGLN3 Q9H6Z9 Prolyl hydroxylase EGLN3 chr14 Not Cancer Driver No 1 hippie 33 13 0 0 0
EIF2B2 EIF2B2 P49770 Translation initiation factor eIF-2B subunit beta chr14 Not Cancer Driver No 1 hippie, biogrid 40 83 11 11 9
EIF2B3 EIF2B3 Q9NR50 Translation initiation factor eIF-2B subunit gamma chr1 Not Cancer Driver No 1 hippie, biogrid 54 28 9 9 5
EIF2B4_ENST00000347454 EIF2B4 Q9UI10 Translation initiation factor eIF-2B subunit delta chr2 Not Cancer Driver No 2 intact, hippie, biogrid 57 212 29 29 7
EIF2B5 EIF2B5 Q13144 Translation initiation factor eIF-2B subunit epsilon chr3 Not Cancer Driver No 1 hippie, biogrid 76 179 16 16 29
EIF3J EIF3J O75822 Eukaryotic translation initiation factor 3 subunit J chr15 Not Cancer Driver No 2 intact, hippie, biogrid 17 166 11 11 0
EIF4G3_ENST00000264211 EIF4G3 O43432 Eukaryotic translation initiation factor 4 gamma 3 chr1 Not Cancer Driver No 2 intact, hippie, biogrid 200 1018 127 127 0
ENO3 ENO3 P13929 Beta-enolase chr17 Not Cancer Driver No 1 hippie 46 26 1 1 2
ESPN ESPN B1AK53 Espin chr1 Not Cancer Driver No 1 hippie, biogrid 73 603 63 63 2
ESR1_ENST00000206249 ESR1 P03372 Estrogen receptor chr6 Census, Compendium Yes 1 hippie 121 195 27 27 2
ESR2 ESR2 Q92731 Estrogen receptor beta chr14 Not Cancer Driver No 1 hippie 90 92 11 11 1
EXOC5 EXOC5 O00471 Exocyst complex component 5 chr14 Not Cancer Driver No 2 hippie, biogrid 59 57 4 4 0
EXOC7 EXOC7 Q9UPT5 Exocyst complex component 7 chr17 Not Cancer Driver No 2 intact, hippie, biogrid 95 208 30 30 0
EYA2 EYA2 O00167 Eyes absent homolog 2 chr20 Not Cancer Driver No 1 hippie 107 204 50 50 0
FARP2 FARP2 O94887 FERM, ARHGEF and pleckstrin domain-containing protein 2 chr2 Not Cancer Driver No 1 hippie, biogrid 133 250 39 39 0
FBXO30 FBXO30 Q8TB52 F-box only protein 30 chr6 Not Cancer Driver No 2 hippie, biogrid 87 170 22 22 0
FDFT1_ENST00000615631 FDFT1 P37268 Squalene synthase chr8 Not Cancer Driver No 1 hippie, biogrid 39 19 0 0 0
GBF1 GBF1 Q92538 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 chr10 Not Cancer Driver No 2 intact, hippie, biogrid 216 669 76 76 0
GEMIN2 GEMIN2 O14893 Gem-associated protein 2 chr14 Not Cancer Driver No 2 intact, hippie, biogrid 39 99 6 6 0
GMNN_ENST00000620958 GMNN O75496 Geminin chr6 Not Cancer Driver No 2 intact, hippie, biogrid 24 206 24 24 1
GOLPH3 GOLPH3 Q9H4A6 Golgi phosphoprotein 3 chr5 Not Cancer Driver No 2 intact, hippie, biogrid 41 72 1 1 0
GOLPH3L GOLPH3L Q9H4A5 Golgi phosphoprotein 3-like chr1 Not Cancer Driver No 2 intact, hippie, biogrid 24 81 12 12 0
GON4L GON4L Q3T8J9 GON-4-like protein chr1 Not Cancer Driver No 2 intact, hippie, biogrid 257 1708 210 210 0
GREB1L GREB1L Q9C091 GREB1-like protein chr18 Not Cancer Driver No 1 hippie, biogrid 87 480 22 22 25
GREB1_ENST00000234142 GREB1 Q4ZG55 Protein GREB1 chr2 Not Cancer Driver No 1 hippie, biogrid 313 371 67 67 0
HAUS7 HAUS7 Q99871 HAUS augmin-like complex subunit 7 chrX Not Cancer Driver No 2 intact, hippie, biogrid 51 78 7 7 0
HEATR3 HEATR3 Q7Z4Q2 HEAT repeat-containing protein 3 chr16 Not Cancer Driver No 2 intact, hippie, biogrid 73 134 10 10 0
HIF1AN HIF1AN Q9NWT6 Hypoxia-inducible factor 1-alpha inhibitor chr10 Not Cancer Driver No 1 hippie 37 77 9 9 0
HOOK2 HOOK2 Q96ED9 Protein Hook homolog 2 chr19 Not Cancer Driver No 2 intact, hippie, biogrid 94 487 62 62 0
ILK_ENST00000299421 ILK Q13418 Integrin-linked protein kinase chr11 Not Cancer Driver No 1 hippie 45 71 9 9 0
INIP INIP Q9NRY2 SOSS complex subunit C chr9 Not Cancer Driver No 2 intact, hippie, biogrid 25 79 16 16 0
INTS3_ENST00000435409 INTS3 Q68E01 Integrator complex subunit 3 chr1 Not Cancer Driver No 2 intact, hippie, biogrid 125 213 25 25 0
IPO11_ENST00000325324 IPO11 Q9UI26 Importin-11 chr5 Not Cancer Driver No 2 intact, hippie, biogrid 82 66 4 4 0
IPO7 IPO7 O95373 Importin-7 chr11 Not Cancer Driver No 2 hippie, biogrid 138 202 30 30 0
IPO8 IPO8 O15397 Importin-8 chr12 Not Cancer Driver No 2 intact, hippie, biogrid 130 111 13 13 0
IPO9 IPO9 Q96P70 Importin-9 chr1 Not Cancer Driver No 2 hippie, biogrid 145 102 22 22 0
KCTD9 KCTD9 Q7L273 BTB/POZ domain-containing protein KCTD9 chr8 Not Cancer Driver No 1 hippie 48 27 3 3 0
KIF14 KIF14 Q15058 Kinesin-like protein KIF14 chr1 Not Cancer Driver No 2 intact, hippie, biogrid 222 774 102 102 2
KIF23 KIF23 Q02241 Kinesin-like protein KIF23 chr15 Not Cancer Driver No 1 hippie 102 559 62 62 0
KLF11 KLF11 O14901 Krueppel-like factor 11 chr2 Not Cancer Driver No 1 hippie 57 308 38 38 2
KLHL22 KLHL22 Q53GT1 Kelch-like protein 22 chr22 Not Cancer Driver No 1 hippie, biogrid 90 50 8 8 0
LRPPRC LRPPRC P42704 Leucine-rich PPR motif-containing protein, mitochondrial chr2 Not Cancer Driver No 1 hippie, biogrid 131 18 2 2 1
LSS LSS P48449 Lanosterol synthase chr21 Not Cancer Driver No 3 intact, hippie, biogrid 85 31 5 5 6
MAD2L2 MAD2L2 Q9UI95 Mitotic spindle assembly checkpoint protein MAD2B chr1 Not Cancer Driver No 1 hippie 22 0 0 0 1
MAGEA11 MAGEA11 P43364 Melanoma-associated antigen 11 chrX Not Cancer Driver No 1 hippie 115 217 49 49 0
MAPK3 MAPK3 P27361 Mitogen-activated protein kinase 3 chr16 Not Cancer Driver No 1 hippie, biogrid 38 49 5 5 0
MAPK6 MAPK6 Q16659 Mitogen-activated protein kinase 6 chr15 Not Cancer Driver No 1 hippie 79 165 20 20 0
MIGA1_ENST00000370791 MIGA1 Q8NAN2 Mitoguardin 1 chr1 Not Cancer Driver No 2 intact, hippie 83 34 6 6 0
MLXIP MLXIP Q9HAP2 MLX-interacting protein chr12 Not Cancer Driver No 2 intact, hippie, biogrid 85 578 42 42 0
MYL12B_ENST00000237500 MYL12B O14950 Myosin regulatory light chain 12B chr18 Not Cancer Driver No 1 hippie 23 61 13 13 0
NCAPD2 NCAPD2 Q15021 Condensin complex subunit 1 chr12 Not Cancer Driver No 2 intact, hippie, biogrid 124 345 35 35 0
NCAPD3 NCAPD3 P42695 Condensin-2 complex subunit D3 chr11 Not Cancer Driver No 1 hippie, biogrid 193 304 42 42 1
NCAPH2_ENST00000420993 NCAPH2 Q6IBW4 Condensin-2 complex subunit H2 chr22 Not Cancer Driver No 1 hippie, biogrid 67 335 39 39 0
NCSTN NCSTN Q92542 Nicastrin chr1 Not Cancer Driver No 1 intact, hippie 94 72 11 11 1
NEURL4 NEURL4 Q96JN8 Neuralized-like protein 4 chr17 Not Cancer Driver No 1 intact, hippie 217 751 119 119 0
NPC1 NPC1 O15118 NPC intracellular cholesterol transporter 1 chr18 Not Cancer Driver No 1 hippie 155 24 0 0 150
NR6A1 NR6A1 Q15406 Nuclear receptor subfamily 6 group A member 1 chr9 Not Cancer Driver No 1 hippie, biogrid 43 124 4 4 0
NUP107 NUP107 P57740 Nuclear pore complex protein Nup107 chr12 Not Cancer Driver No 1 hippie, biogrid 127 183 26 26 5
NUP160 NUP160 Q12769 Nuclear pore complex protein Nup160 chr11 Not Cancer Driver No 1 hippie, biogrid 138 48 1 1 0
NUP37_ENST00000251074 NUP37 Q8NFH4 Nucleoporin Nup37 chr12 Not Cancer Driver No 1 hippie, biogrid 39 0 0 0 0
NUP58 NUP58 Q9BVL2 Nucleoporin p58/p45 chr13 Not Cancer Driver No 1 hippie 76 377 49 49 0
NUP85 NUP85 Q9BW27 Nuclear pore complex protein Nup85 chr17 Not Cancer Driver No 2 hippie, biogrid 68 32 4 4 2
NUP98_ENST00000359171 NUP98 P52948 Nuclear pore complex protein Nup98-Nup96 chr11 Census Yes 2 hippie, biogrid 227 1008 107 107 0
OTUB1_ENST00000428192 OTUB1 Q96FW1 Ubiquitin thioesterase OTUB1 chr11 Not Cancer Driver No 1 intact, hippie 31 33 2 2 0
PAK1_ENST00000356341 PAK1 Q13153 Serine/threonine-protein kinase PAK 1 chr11 Not Cancer Driver No 1 hippie 57 299 30 30 2
PBXIP1 PBXIP1 Q96AQ6 Pre-B-cell leukemia transcription factor-interacting protein 1 chr1 Not Cancer Driver No 3 hippie, biogrid 100 605 86 86 0
PEX19 PEX19 P40855 Peroxisomal biogenesis factor 19 chr1 Not Cancer Driver No 2 intact, hippie, biogrid 41 266 38 38 0
PJA1 PJA1 Q8NG27 E3 ubiquitin-protein ligase Praja-1 chrX Not Cancer Driver No 1 hippie, biogrid 112 525 94 94 0
PLEKHA4 PLEKHA4 Q9H4M7 Pleckstrin homology domain-containing family A member 4 chr19 Not Cancer Driver No 1 hippie 136 687 128 128 0
PPARGC1B PPARGC1B Q86YN6 Peroxisome proliferator-activated receptor gamma coactivator 1-beta chr5 Not Cancer Driver No 2 hippie, biogrid 125 845 99 99 0
PPFIBP1 PPFIBP1 Q86W92 Liprin-beta-1 chr12 Census Yes 2 intact, hippie, biogrid 110 555 57 57 0
PPIB PPIB P23284 Peptidyl-prolyl cis-trans isomerase B chr15 Not Cancer Driver No 1 intact, hippie 28 16 1 1 1
PPP4R3B PPP4R3B Q5MIZ7 Serine/threonine-protein phosphatase 4 regulatory subunit 3B chr2 Not Cancer Driver No 2 intact, hippie 100 240 33 33 0
PPP6R1_ENST00000587283 PPP6R1 Q9UPN7 Serine/threonine-protein phosphatase 6 regulatory subunit 1 chr19 Not Cancer Driver No 2 intact, hippie, biogrid 82 471 47 47 0
PPP6R2_ENST00000216061 PPP6R2 O75170 Serine/threonine-protein phosphatase 6 regulatory subunit 2 chr22 Not Cancer Driver No 1 hippie, biogrid 103 491 63 63 0
PRMT9 PRMT9 Q6P2P2 Protein arginine N-methyltransferase 9 chr4 Not Cancer Driver No 3 hippie, biogrid 84 63 4 4 0
RADIL RADIL Q96JH8 Ras-associating and dilute domain-containing protein chr7 Not Cancer Driver No 2 intact, hippie, biogrid 173 381 62 62 0
RAMP3 RAMP3 O60896 Receptor activity-modifying protein 3 chr7 Not Cancer Driver No 1 hippie, biogrid 30 0 0 0 0
RANBP6 RANBP6 O60518 Ran-binding protein 6 chr9 Not Cancer Driver No 2 intact, hippie, biogrid 152 46 4 4 0
RIPK4_ENST00000352483 RIPK4 P57078 Receptor-interacting serine/threonine-protein kinase 4 chr21 Not Cancer Driver No 1 intact, hippie 119 232 34 34 3
RNF31 RNF31 Q96EP0 E3 ubiquitin-protein ligase RNF31 chr14 Not Cancer Driver No 1 hippie 142 319 45 45 0
RRP1 RRP1 P56182 Ribosomal RNA processing protein 1 homolog A chr21 Not Cancer Driver No 2 intact, hippie, biogrid 36 230 18 18 0
RTF2_ENST00000357348 RTF2 Q9BY42 Replication termination factor 2 chr20 Not Cancer Driver No 1 hippie 44 170 22 22 0
S100A9 S100A9 P06702 Protein S100-A9 chr1 Not Cancer Driver No 1 hippie 18 76 7 7 0
SAAL1 SAAL1 Q96ER3 Protein SAAL1 chr11 Not Cancer Driver No 2 hippie, biogrid 46 75 11 11 0
SCARB2 SCARB2 Q14108 Lysosome membrane protein 2 chr4 Not Cancer Driver No 1 hippie 61 13 3 3 1
SETX SETX Q7Z333 Probable helicase senataxin chr9 Not Cancer Driver No 2 intact, hippie, biogrid 342 1240 156 156 20
SFXN1 SFXN1 Q9H9B4 Sideroflexin-1 chr5 Not Cancer Driver No 1 hippie, biogrid 31 29 1 1 0
SLC25A13_ENST00000265631 SLC25A13 Q9UJS0 Calcium-binding mitochondrial carrier protein Aralar2 chr7 Not Cancer Driver No 1 hippie 111 23 2 2 1
STAG1 STAG1 Q8WVM7 Cohesin subunit SA-1 chr3 Census Yes 2 intact, hippie, biogrid 226 391 66 66 8
STAG2_ENST00000371157 STAG2 Q8N3U4 Cohesin subunit SA-2 chrX Census, Compendium Yes 2 intact, hippie, biogrid 179 330 46 46 3
STOM STOM P27105 Stomatin chr9 Not Cancer Driver No 1 hippie, biogrid 23 44 3 3 0
TAF12_ENST00000373824 TAF12 Q16514 Transcription initiation factor TFIID subunit 12 chr1 Not Cancer Driver No 2 intact, hippie, biogrid 11 107 7 7 0
TARBP2 TARBP2 Q15633 RISC-loading complex subunit TARBP2 chr12 Not Cancer Driver No 2 intact, hippie, biogrid 45 203 22 22 0
TBC1D15 TBC1D15 Q8TC07 TBC1 domain family member 15 chr12 Not Cancer Driver No 2 intact, hippie, biogrid 90 135 23 23 0
TBC1D5_ENST00000253692 TBC1D5 Q92609 TBC1 domain family member 5 chr3 Not Cancer Driver No 1 hippie, biogrid 117 358 58 58 0
TFIP11_ENST00000407148 TFIP11 Q9UBB9 Tuftelin-interacting protein 11 chr22 Not Cancer Driver No 2 intact, hippie, biogrid 87 331 39 39 0
TIMM10B TIMM10B Q9Y5J6 Mitochondrial import inner membrane translocase subunit Tim10 B chr11 Not Cancer Driver No 1 hippie, biogrid 6 24 3 3 0
TIMM10_ENST00000525587 TIMM10 P62072 Mitochondrial import inner membrane translocase subunit Tim10 chr11 Not Cancer Driver No 1 hippie, biogrid 6 43 6 6 0
TNPO2 TNPO2 O14787 Transportin-2 chr19 Not Cancer Driver No 2 hippie, biogrid 99 76 10 10 0
TSC2 TSC2 P49815 Tuberin chr16 Census, Compendium Yes 2 intact, hippie, biogrid 192 563 50 50 53
TUBB2A TUBB2A Q13885 Tubulin beta-2A chain chr6 Not Cancer Driver No 1 hippie, biogrid 44 70 13 13 2
UBR3 UBR3 Q6ZT12 E3 ubiquitin-protein ligase UBR3 chr2 Not Cancer Driver No 1 hippie, biogrid 154 339 28 28 0
VPS8 VPS8 Q8N3P4 Vacuolar protein sorting-associated protein 8 homolog chr3 Not Cancer Driver No 2 intact, hippie, biogrid 184 186 30 30 0
XPO4 XPO4 Q9C0E2 Exportin-4 chr13 Not Cancer Driver No 2 intact, hippie, biogrid 124 66 5 5 0