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PKP1 ,PKP1 ,Q13835
  • Uniprot Accession= Q13835
  • Ensembl Transcript= ENST00000263946.7
  • Uniprot Name= PKP1
  • Name= Plakophilin-1
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 15
  • Number of Interaction partner in biogrid: 72
  • Number of Interaction partner in hippie: 121
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ACO2 ACO2 Q99798 Aconitate hydratase, mitochondrial chr22 Not Cancer Driver No 1 intact 94 172 19 19 5
ALDH2 ALDH2 P05091 Aldehyde dehydrogenase, mitochondrial chr12 Census Yes 1 hippie, biogrid 60 44 1 1 0
ANXA2_ENST00000396024 ANXA2 P07355 Annexin A2 chr15 Not Cancer Driver No 1 hippie, biogrid 49 20 4 4 0
ANXA9 ANXA9 O76027 Annexin A9 chr1 Not Cancer Driver No 1 hippie, biogrid 52 42 7 7 0
ARAF_ENST00000377045 ARAF P10398 Serine/threonine-protein kinase A-Raf chrX Census, Compendium Yes 1 intact, hippie 84 181 32 32 0
ARMC8_ENST00000469044 ARMC8 Q8IUR7 Armadillo repeat-containing protein 8 chr3 Not Cancer Driver No 1 intact, hippie 71 7 0 0 0
ATP6V0A1_ENST00000343619 ATP6V0A1 Q93050 V-type proton ATPase 116 kDa subunit a 1 chr17 Not Cancer Driver No 1 hippie 98 85 14 14 0
BICDL2 BICDL2 A1A5D9 BICD family-like cargo adapter 2 chr16 Not Cancer Driver No 1 hippie 50 446 49 49 0
BIRC3_ENST00000532808 BIRC3 Q13489 Baculoviral IAP repeat-containing protein 3 chr11 Census, Compendium Yes 1 hippie 77 98 16 16 0
BLMH BLMH Q13867 Bleomycin hydrolase chr17 Not Cancer Driver No 1 hippie, biogrid 54 15 1 1 0
BMI1 BMI1 P35226 Polycomb complex protein BMI-1 chr10 Not Cancer Driver No 1 hippie 50 150 30 30 0
C18orf21 C18orf21 Q32NC0 UPF0711 protein C18orf21 chr18 Not Cancer Driver No 1 hippie, biogrid 21 112 12 12 0
CA8 CA8 P35219 Carbonic anhydrase-related protein chr8 Not Cancer Driver No 2 hippie, biogrid 56 32 2 2 1
CAPZA2 CAPZA2 P47755 F-actin-capping protein subunit alpha-2 chr7 Not Cancer Driver No 1 hippie, biogrid 37 19 0 0 0
CARD10_ENST00000251973 CARD10 Q9BWT7 Caspase recruitment domain-containing protein 10 chr22 Not Cancer Driver No 1 hippie 94 474 40 40 0
CASP14 CASP14 P31944 Caspase-14 chr19 Not Cancer Driver No 1 hippie, biogrid 50 84 13 13 0
CCDC51 CCDC51 Q96ER9 Mitochondrial potassium channel chr3 Not Cancer Driver No 3 hippie, biogrid 51 137 21 21 0
CCDC8 CCDC8 Q9H0W5 Coiled-coil domain-containing protein 8 chr19 Not Cancer Driver No 1 hippie 96 505 91 91 0
CCDC82_ENST00000278520 CCDC82 Q8N4S0 Coiled-coil domain-containing protein 82 chr11 Not Cancer Driver No 2 hippie, biogrid 74 328 36 36 0
CCR1 CCR1 P32246 C-C chemokine receptor type 1 chr3 Not Cancer Driver No 1 hippie, biogrid 69 14 5 5 0
CD109 CD109 Q6YHK3 CD109 antigen chr6 Not Cancer Driver No 1 hippie, biogrid 204 54 11 11 0
CEP76 CEP76 Q8TAP6 Centrosomal protein of 76 kDa chr18 Not Cancer Driver No 1 hippie 63 96 7 7 0
CHD4 CHD4 Q14839 Chromodomain-helicase-DNA-binding protein 4 chr12 Census, Compendium Yes 1 hippie 419 974 177 177 6
CIDEA CIDEA O60543 Cell death activator CIDE-A chr18 Not Cancer Driver No 3 hippie, biogrid 43 32 3 3 0
COASY_ENST00000421097 COASY Q13057 Bifunctional coenzyme A synthase chr17 Not Cancer Driver No 1 hippie, biogrid 57 50 4 4 1
CPLANE2 CPLANE2 Q9BU20 Ciliogenesis and planar polarity effector 2 chr1 Not Cancer Driver No 1 hippie 37 21 3 3 0
CPLX3 CPLX3 Q8WVH0 Complexin-3 chr15 Not Cancer Driver No 1 hippie, biogrid 26 149 25 25 0
CSGALNACT1_ENST00000332246 CSGALNACT1 Q8TDX6 Chondroitin sulfate N-acetylgalactosaminyltransferase 1 chr8 Not Cancer Driver No 1 hippie, biogrid 91 131 28 28 0
CTSD CTSD P07339 Cathepsin D chr11 Not Cancer Driver No 1 hippie, biogrid 57 6 1 1 2
CYLD CYLD Q9NQC7 Ubiquitin carboxyl-terminal hydrolase CYLD chr16 Census, Compendium Yes 1 hippie 116 213 31 31 3
DDX39B_ENST00000458640 DDX39B Q13838 Spliceosome RNA helicase DDX39B chr6 Not Cancer Driver No 1 hippie 49 34 8 8 0
DDX3X_ENST00000629496 DDX3X O00571 ATP-dependent RNA helicase DDX3X chrX Census, Compendium Yes 1 hippie 133 301 47 47 18
DSC1 DSC1 Q08554 Desmocollin-1 chr18 Not Cancer Driver No 2 hippie, biogrid 219 265 65 65 0
DSG1 DSG1 Q02413 Desmoglein-1 chr18 Not Cancer Driver No 2 hippie, biogrid 250 496 130 130 0
DSP DSP P15924 Desmoplakin chr6 Not Cancer Driver No 2 hippie, biogrid 483 1124 204 204 6
FAM160A1_ENST00000505231 FHIP1A Q05DH4 FHF complex subunit HOOK interacting protein 1A chr4 Not Cancer Driver No 1 intact 47 341 8 8 0
FANCD2_ENST00000383807 FANCD2 Q9BXW9 Fanconi anemia group D2 protein chr3 Census, Compendium Yes 1 hippie 176 181 14 14 3
FBXL4_ENST00000229971 FBXL4 Q9UKA2 F-box/LRR-repeat protein 4 chr6 Not Cancer Driver No 2 hippie, biogrid 82 23 2 2 7
FBXW7_ENST00000603841 FBXW7 Q969H0 F-box/WD repeat-containing protein 7 chr4 Census, Compendium Yes 1 hippie 322 230 38 38 0
FCF1 FCF1 Q9Y324 rRNA-processing protein FCF1 homolog chr14 Not Cancer Driver No 2 hippie, biogrid 28 46 4 4 0
FLG FLG P20930 Filaggrin chr1 Not Cancer Driver No 1 hippie, biogrid 1612 3956 1593 1593 0
FLG2 FLG2 Q5D862 Filaggrin-2 chr1 Not Cancer Driver No 1 hippie, biogrid 613 2252 577 577 0
FNDC5_ENST00000640867 FNDC5 Q8NAU1 Fibronectin type III domain-containing protein 5 chr1 Not Cancer Driver No 1 hippie, biogrid 17 74 8 8 0
FOS FOS P01100 Protein c-Fos chr14 Not Cancer Driver No 1 hippie, biogrid 45 245 33 33 0
FOXI2 FOXI2 Q6ZQN5 Forkhead box protein I2 chr10 Not Cancer Driver No 1 intact, hippie 32 165 22 22 0
FSTL1 FSTL1 Q12841 Follistatin-related protein 1 chr3 Not Cancer Driver No 1 hippie, biogrid 41 51 7 7 0
GABARAPL1_ENST00000545887 GABARAPL1 Q9H0R8 Gamma-aminobutyric acid receptor-associated protein-like 1 chr12 Not Cancer Driver No 1 hippie 19 10 1 1 0
GABARAPL2 GABARAPL2 P60520 Gamma-aminobutyric acid receptor-associated protein-like 2 chr16 Not Cancer Driver No 1 hippie 11 2 1 1 0
GABPA_ENST00000400075 GABPA Q06546 GA-binding protein alpha chain chr21 Not Cancer Driver No 1 hippie, biogrid 58 103 8 8 0
GDI2 GDI2 P50395 Rab GDP dissociation inhibitor beta chr10 Not Cancer Driver No 1 intact 49 23 2 2 0
GOLGA2_ENST00000611957 GOLGA2 Q08379 Golgin subfamily A member 2 chr9 Not Cancer Driver No 1 hippie 115 854 96 96 0
GOSR1 GOSR1 O95249 Golgi SNAP receptor complex member 1 chr17 Not Cancer Driver No 1 intact, hippie 26 108 11 11 0
GOT1 GOT1 P17174 Aspartate aminotransferase, cytoplasmic chr10 Not Cancer Driver No 1 hippie, biogrid 56 35 5 5 0
GPATCH2L GPATCH2L Q9NWQ4 G patch domain-containing protein 2-like chr14 Not Cancer Driver No 1 hippie, biogrid 63 380 48 48 0
GTF2IRD1_ENST00000265755 GTF2IRD1 Q9UHL9 General transcription factor II-I repeat domain-containing protein 1 chr7 Not Cancer Driver No 1 hippie 136 378 56 56 0
HCN1 HCN1 O60741 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 chr5 Not Cancer Driver No 1 hippie, biogrid 432 365 187 187 16
HNRNPA1 HNRNPA1 P09651 Heterogeneous nuclear ribonucleoprotein A1 chr12 Not Cancer Driver No 1 hippie 70 290 58 58 4
HOOK2 HOOK2 Q96ED9 Protein Hook homolog 2 chr19 Not Cancer Driver No 1 hippie 94 487 62 62 0
HSF2BP HSF2BP O75031 Heat shock factor 2-binding protein chr21 Not Cancer Driver No 1 hippie 52 23 3 3 1
IVL IVL P07476 Involucrin chr1 Not Cancer Driver No 1 hippie, biogrid 115 585 115 115 0
JADE1_ENST00000512960 JADE1 Q6IE81 Protein Jade-1 chr4 Not Cancer Driver No 1 intact, hippie, biogrid 94 409 47 47 0
KDELR2 KDELR2 P33947 ER lumen protein-retaining receptor 2 chr7 Not Cancer Driver No 1 hippie, biogrid 23 0 0 0 1
KIF3A_ENST00000378746 KIF3A Q9Y496 Kinesin-like protein KIF3A chr5 Not Cancer Driver No 2 hippie, biogrid 92 409 59 59 0
KRT14 KRT14 P02533 Keratin, type I cytoskeletal 14 chr17 Not Cancer Driver No 1 hippie 76 183 31 31 40
KRT15_ENST00000393976 KRT15 P19012 Keratin, type I cytoskeletal 15 chr17 Not Cancer Driver No 1 hippie 95 191 34 34 0
KRT18_ENST00000388837 KRT18 P05783 Keratin, type I cytoskeletal 18 chr12 Not Cancer Driver No 1 hippie 57 179 21 21 4
KRT5 KRT5 P13647 Keratin, type II cytoskeletal 5 chr12 Not Cancer Driver No 1 hippie 112 193 47 47 50
KRT8_ENST00000546897 KRT8 P05787 Keratin, type II cytoskeletal 8 chr12 Not Cancer Driver No 1 hippie 65 221 37 37 3
LNX1 LNX1 Q8TBB1 E3 ubiquitin-protein ligase LNX chr4 Not Cancer Driver No 1 hippie 117 261 40 40 0
LRRK2 LRRK2 Q5S007 Leucine-rich repeat serine/threonine-protein kinase 2 chr12 Not Cancer Driver No 1 intact, hippie 519 90 17 17 23
LSM1 LSM1 O15116 U6 snRNA-associated Sm-like protein LSm1 chr8 Not Cancer Driver No 1 intact 21 6 1 1 0
MBNL1_ENST00000463374 MBNL1 Q9NR56 Muscleblind-like protein 1 chr3 Not Cancer Driver No 1 hippie, biogrid 56 153 20 20 0
MCM2 MCM2 P49736 DNA replication licensing factor MCM2 chr3 Not Cancer Driver No 1 hippie 104 275 38 38 1
METTL7A_ENST00000332160 METTL7A Q9H8H3 Putative methyltransferase-like protein 7A chr12 Not Cancer Driver No 1 hippie, biogrid 31 0 0 0 0
MICU3 MICU3 Q86XE3 Calcium uptake protein 3, mitochondrial chr8 Not Cancer Driver No 1 hippie, biogrid 72 89 8 8 0
MOSPD2 MOSPD2 Q8NHP6 Motile sperm domain-containing protein 2 chrX Not Cancer Driver No 1 intact, hippie 58 143 16 16 0
MYC_ENST00000377970 MYC P01106 Myc proto-oncogene protein chr8 Census, Compendium Yes 1 hippie 80 299 46 46 0
NDUFS5_ENST00000372967 NDUFS5 O43920 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 chr1 Not Cancer Driver No 1 hippie, biogrid 15 31 3 3 0
NEK2 NEK2 P51955 Serine/threonine-protein kinase Nek2 chr1 Not Cancer Driver No 1 hippie 61 92 19 19 0
NFKBID NFKBID Q8NI38 NF-kappa-B inhibitor delta chr19 Not Cancer Driver No 1 hippie 47 124 20 20 0
NRSN1 NRSN1 Q8IZ57 Neurensin-1 chr6 Not Cancer Driver No 1 hippie, biogrid 46 17 9 9 0
OAZ3_ENST00000639906 OAZ3 Q9UMX2 Ornithine decarboxylase antizyme 3 chr1 Not Cancer Driver No 1 hippie, biogrid 37 33 2 2 0
OPN5 OPN5 Q6U736 Opsin-5 chr6 Not Cancer Driver No 1 hippie, biogrid 65 0 0 0 0
OR2A4 OR2A4 O95047 Olfactory receptor 2A4 chr6 Not Cancer Driver No 1 hippie, biogrid 44 0 0 0 0
P2RX6 P2RX6 O15547 P2X purinoceptor 6 chr22 Not Cancer Driver No 1 hippie, biogrid 33 43 1 1 0
PDE4DIP_ENST00000369354 PDE4DIP Q5VU43 Myomegalin chr1 Census, Compendium Yes 1 hippie, biogrid 555 1633 395 395 0
PEMT_ENST00000395783 PEMT Q9UBM1 Phosphatidylethanolamine N-methyltransferase chr17 Not Cancer Driver No 1 hippie, biogrid 21 1 0 0 0
PHF11 PHF11 Q9UIL8 PHD finger protein 11 chr13 Not Cancer Driver No 1 hippie, biogrid 34 82 10 10 0
PHF8 PHF8 Q9UPP1 Histone lysine demethylase PHF8 chrX Not Cancer Driver No 1 hippie, biogrid 154 603 93 93 1
PINK1 PINK1 Q9BXM7 Serine/threonine-protein kinase PINK1, mitochondrial chr1 Not Cancer Driver No 1 hippie, biogrid 57 99 13 13 23
PKP2 PKP2 Q99959 Plakophilin-2 chr12 Not Cancer Driver No 1 intact 176 434 98 98 8
PLD5 PLD5 Q8N7P1 Inactive phospholipase D5 chr1 Not Cancer Driver No 1 hippie, biogrid 152 62 18 18 0
POC5 POC5 Q8NA72 Centrosomal protein POC5 chr5 Not Cancer Driver No 1 hippie 64 352 46 46 0
POF1B_ENST00000262753 POF1B Q8WVV4 Protein POF1B chrX Not Cancer Driver No 1 hippie, biogrid 154 391 104 104 1
POLR2L POLR2L P62875 DNA-directed RNA polymerases I, II, and III subunit RPABC5 chr11 Not Cancer Driver No 1 hippie, biogrid 10 0 0 0 0
PPP2R2B_ENST00000394409 PPP2R2B Q00005 Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform chr5 Not Cancer Driver No 1 hippie, biogrid 101 76 22 22 0
PRPF8 PRPF8 Q6P2Q9 Pre-mRNA-processing-splicing factor 8 chr17 Not Cancer Driver No 1 hippie 255 225 26 26 8
PTDSS1 PTDSS1 P48651 Phosphatidylserine synthase 1 chr8 Not Cancer Driver No 1 hippie, biogrid 81 44 7 7 3
RANBP9 RANBP9 Q96S59 Ran-binding protein 9 chr6 Not Cancer Driver No 1 hippie 73 413 30 30 0
RBFOX1_ENST00000550418 RBFOX1 Q9NWB1 RNA binding protein fox-1 homolog 1 chr16 Compendium Yes 1 hippie, biogrid 179 181 89 89 0
RBM24 RBM24 Q9BX46 RNA-binding protein 24 chr6 Not Cancer Driver No 2 hippie, biogrid 29 20 3 3 0
SERPINB12_ENST00000269491 SERPINB12 Q96P63 Serpin B12 chr18 Not Cancer Driver No 1 hippie, biogrid 82 21 6 6 0
SERPINB3 SERPINB3 P29508 Serpin B3 chr18 Not Cancer Driver No 1 hippie, biogrid 142 47 28 28 0
SERPINB5 SERPINB5 P36952 Serpin B5 chr18 Not Cancer Driver No 1 hippie, biogrid 57 50 7 7 0
SGO2 SGO2 Q562F6 Shugoshin 2 chr2 Not Cancer Driver No 1 hippie 164 1025 134 134 0
SLC37A4_ENST00000545985 SLC37A4 O43826 Glucose-6-phosphate exchanger SLC37A4 chr11 Not Cancer Driver No 1 hippie, biogrid 41 17 1 1 32
SMARCB1_ENST00000644036 SMARCB1 Q12824 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 chr22 Census, Compendium Yes 1 intact 64 141 35 35 3
SPICE1 SPICE1 Q8N0Z3 Spindle and centriole-associated protein 1 chr3 Not Cancer Driver No 1 hippie, biogrid 112 729 92 92 0
SRRT SRRT Q9BXP5 Serrate RNA effector molecule homolog chr7 Not Cancer Driver No 1 hippie, biogrid 146 595 108 108 0
SSUH2 SSUH2 Q9Y2M2 Protein SSUH2 homolog chr3 Not Cancer Driver No 1 hippie, biogrid 58 76 7 7 0
ST6GALNAC6_ENST00000373146 ST6GALNAC6 Q969X2 Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 chr9 Not Cancer Driver No 1 hippie, biogrid 44 86 13 13 0
STX17_ENST00000534052 STX17 P56962 Syntaxin-17 chr9 Not Cancer Driver No 1 hippie, biogrid 27 81 4 4 0
SUMO1_ENST00000392245 SUMO1 P63165 Small ubiquitin-related modifier 1 chr2 Not Cancer Driver No 1 hippie 10 76 7 7 0
SUZ12 SUZ12 Q15022 Polycomb protein SUZ12 chr17 Census, Compendium Yes 1 hippie 83 483 46 46 3
TARDBP TARDBP Q13148 TAR DNA-binding protein 43 chr1 Not Cancer Driver No 1 hippie, biogrid 51 202 15 15 27
TEX10 TEX10 Q9NXF1 Testis-expressed protein 10 chr9 Not Cancer Driver No 1 hippie, biogrid 115 103 12 12 0
TFG TFG Q92734 Protein TFG chr3 Census, Compendium Yes 2 hippie, biogrid 45 290 34 34 3
TGM3 TGM3 Q08188 Protein-glutamine gamma-glutamyltransferase E chr20 Not Cancer Driver No 1 hippie, biogrid 141 85 19 19 0
TNS2_ENST00000314250 TNS2 Q63HR2 Tensin-2 chr12 Not Cancer Driver No 1 intact, hippie 132 799 63 63 0
TUBG1 TUBG1 P23258 Tubulin gamma-1 chain chr17 Not Cancer Driver No 1 hippie 51 44 10 10 3
UBD UBD O15205 Ubiquitin D chr6 Not Cancer Driver No 1 hippie 31 8 1 1 0
UCHL5 UCHL5 Q9Y5K5 Ubiquitin carboxyl-terminal hydrolase isozyme L5 chr1 Not Cancer Driver No 1 hippie 33 41 7 7 0
USP1_ENST00000371146 USP1 O94782 Ubiquitin carboxyl-terminal hydrolase 1 chr1 Not Cancer Driver No 1 intact, hippie, biogrid 63 403 30 30 0
VIM_ENST00000224237 VIM P08670 Vimentin chr10 Not Cancer Driver No 1 hippie 84 316 57 57 1
WIPI1 WIPI1 Q5MNZ9 WD repeat domain phosphoinositide-interacting protein 1 chr17 Not Cancer Driver No 1 hippie 45 113 9 9 0
ZC3HC1 ZC3HC1 Q86WB0 Zinc finger C3HC-type protein 1 chr7 Not Cancer Driver No 1 hippie, biogrid 70 250 34 34 0
ZDHHC19 ZDHHC19 Q8WVZ1 Palmitoyltransferase ZDHHC19 chr3 Not Cancer Driver No 1 hippie, biogrid 48 35 10 10 0