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PKN2 ,PKN2 ,Q16513
  • Uniprot Accession= Q16513
  • Ensembl Transcript= ENST00000370521.7
  • Uniprot Name= PKN2
  • Name= Serine/threonine-protein kinase N2
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 58
  • Number of Interaction partner in biogrid: 57
  • Number of Interaction partner in hippie: 143
Identifier
UniProt Gene
UniProt Accession
UniProt Name
Chromosome
Cancer Database
Cancer Driver
Number of independent pubication
Interaction Database
Number of missense mutations
Number of disordered residues
Number of mutations in disordered residues
Number of mutations in disordered residues
Number of omim mutations
ACBD3 ACBD3 Q9H3P7 Golgi resident protein GCP60 chr1 Not Cancer Driver No 1 hippie, biogrid 59 350 40 40 0
AHSA1 AHSA1 O95433 Activator of 90 kDa heat shock protein ATPase homolog 1 chr14 Not Cancer Driver No 1 hippie 46 146 17 17 0
AKT1_ENST00000349310 AKT1 P31749 RAC-alpha serine/threonine-protein kinase chr14 Census, Compendium Yes 1 hippie 108 158 24 24 4
ANAPC2 ANAPC2 Q9UJX6 Anaphase-promoting complex subunit 2 chr9 Not Cancer Driver No 1 hippie, biogrid 104 146 26 26 0
ANXA1_ENST00000257497 ANXA1 P04083 Annexin A1 chr9 Not Cancer Driver No 1 intact, hippie, biogrid 59 61 12 12 0
ATP2A2 ATP2A2 P16615 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 chr12 Not Cancer Driver No 1 intact, hippie 136 78 14 14 41
ATP5PB ATP5PB P24539 ATP synthase F(0) complex subunit B1, mitochondrial chr1 Not Cancer Driver No 1 hippie 37 2 0 0 0
BTF3 BTF3 P20290 Transcription factor BTF3 chr5 Not Cancer Driver No 1 hippie 27 192 24 24 0
CAMKV CAMKV Q8NCB2 CaM kinase-like vesicle-associated protein chr3 Not Cancer Driver No 2 intact, hippie, biogrid 87 226 30 30 0
CASP3 CASP3 P42574 Caspase-3 chr4 Census Yes 1 hippie 32 62 5 5 0
CCDC136 CCDC136 Q96JN2 Coiled-coil domain-containing protein 136 chr7 Not Cancer Driver No 1 hippie 150 818 114 114 0
CCNB1 CCNB1 P14635 G2/mitotic-specific cyclin-B1 chr5 Not Cancer Driver No 1 hippie, biogrid 49 145 14 14 0
CCT6A CCT6A P40227 T-complex protein 1 subunit zeta chr7 Not Cancer Driver No 1 hippie, biogrid 66 5 1 1 0
CDC42_ENST00000344548 CDC42 P60953 Cell division control protein 42 homolog chr1 Not Cancer Driver No 1 hippie 39 23 2 2 1
CDC5L CDC5L Q99459 Cell division cycle 5-like protein chr6 Not Cancer Driver No 1 intact, hippie 100 618 77 77 0
CDH1 CDH1 P12830 Cadherin-1 chr16 Census, Compendium Yes 1 hippie 150 400 82 82 5
CEBPA CEBPA P49715 CCAAT/enhancer-binding protein alpha chr19 Census, Compendium Yes 1 hippie 12 342 12 12 1
CENPJ CENPJ Q9HC77 Centromere protein J chr13 Not Cancer Driver No 1 intact, hippie 176 1176 158 158 1
CEP128_ENST00000281129 CEP128 Q6ZU80 Centrosomal protein of 128 kDa chr14 Not Cancer Driver No 1 hippie 195 897 167 167 0
CEP162 CEP162 Q5TB80 Centrosomal protein of 162 kDa chr6 Not Cancer Driver No 1 intact, hippie 162 1056 128 128 0
CEP19 CEP19 Q96LK0 Centrosomal protein of 19 kDa chr3 Not Cancer Driver No 1 intact, hippie 30 71 11 11 0
CEP44_ENST00000296519 CEP44 Q9C0F1 Centrosomal protein of 44 kDa chr4 Not Cancer Driver No 1 hippie 55 142 17 17 0
CES2 CES2 O00748-4 Isoform 3 of Cocaine esterase chr16 Not Cancer Driver No 1 hippie, biogrid 62 157 18 18 0
CETN1 CETN1 Q12798 Centrin-1 chr18 Not Cancer Driver No 2 intact, hippie, biogrid 65 105 43 43 0
CETN2 CETN2 P41208 Centrin-2 chrX Not Cancer Driver No 1 intact, hippie 33 97 11 11 0
CHGB CHGB P05060 Secretogranin-1 chr20 Not Cancer Driver No 1 hippie 174 575 153 153 0
CKAP4 CKAP4 Q07065 Cytoskeleton-associated protein 4 chr12 Not Cancer Driver No 1 intact, hippie 73 409 55 55 0
CTNNA3 CTNNA3 Q9UI47 Catenin alpha-3 chr10 Not Cancer Driver No 1 hippie, biogrid 269 186 50 50 1
CYP1A1 CYP1A1 P04798 Cytochrome P450 1A1 chr15 Not Cancer Driver No 1 hippie, biogrid 81 17 2 2 0
DEF8 DEF8 Q6ZN54 Differentially expressed in FDCP 8 homolog chr16 Not Cancer Driver No 2 intact, hippie, biogrid 58 123 23 23 0
DFFB_ENST00000378209 DFFB O76075 DNA fragmentation factor subunit beta chr1 Not Cancer Driver No 2 hippie, biogrid 37 27 1 1 0
DNAJC5 DNAJC5 Q9H3Z4 DnaJ homolog subfamily C member 5 chr20 Not Cancer Driver No 1 hippie, biogrid 23 46 6 6 1
DNAJC8 DNAJC8 O75937 DnaJ homolog subfamily C member 8 chr1 Not Cancer Driver No 1 hippie, biogrid 29 188 23 23 0
EEF1A1 EEF1A1 P68104 Elongation factor 1-alpha 1 chr6 Not Cancer Driver No 1 intact, hippie 109 100 14 14 0
EEF1D_ENST00000395119 EEF1D P29692 Elongation factor 1-delta chr8 Not Cancer Driver No 1 intact, hippie 40 153 22 22 0
EEF1E1 EEF1E1 O43324 Eukaryotic translation elongation factor 1 epsilon-1 chr6 Not Cancer Driver No 1 hippie 27 11 1 1 0
EEF1G EEF1G P26641 Elongation factor 1-gamma chr11 Not Cancer Driver No 1 hippie 44 66 5 5 0
EFTUD2 EFTUD2 Q15029 116 kDa U5 small nuclear ribonucleoprotein component chr17 Compendium Yes 1 hippie 132 179 30 30 3
EIF3G EIF3G O75821 Eukaryotic translation initiation factor 3 subunit G chr19 Not Cancer Driver No 1 intact, hippie 41 233 30 30 0
ELAVL1 ELAVL1 Q15717 ELAV-like protein 1 chr19 Not Cancer Driver No 1 hippie 69 43 5 5 0
EP300 EP300 Q09472 Histone acetyltransferase p300 chr22 Census, Compendium Yes 1 hippie 334 1790 196 196 1
ERLIN1 ERLIN1 O75477 Erlin-1 chr10 Not Cancer Driver No 1 hippie 29 46 4 4 1
EZR EZR P15311 Ezrin chr6 Census Yes 1 intact, hippie 66 295 35 35 0
FRMPD2 FRMPD2 Q68DX3 FERM and PDZ domain-containing protein 2 chr10 Not Cancer Driver No 3 intact, hippie, biogrid 254 479 106 106 0
GOPC GOPC Q9HD26 Golgi-associated PDZ and coiled-coil motif-containing protein chr6 Census Yes 2 intact, hippie, biogrid 56 263 34 34 0
HAVCR2 HAVCR2 Q8TDQ0 Hepatitis A virus cellular receptor 2 chr5 Not Cancer Driver No 2 intact, hippie, biogrid 69 17 2 2 3
HDAC5_ENST00000586802 HDAC5 Q9UQL6 Histone deacetylase 5 chr17 Not Cancer Driver No 1 hippie 118 718 73 73 0
HECW2_ENST00000644256 HECW2 Q9P2P5 E3 ubiquitin-protein ligase HECW2 chr2 Not Cancer Driver No 1 hippie 348 845 195 195 4
HSCB HSCB Q8IWL3 Iron-sulfur cluster co-chaperone protein HscB chr22 Not Cancer Driver No 1 intact, hippie 36 25 6 6 0
HSP90AA1_ENST00000216281 HSP90AA1 P07900 Heat shock protein HSP 90-alpha chr14 Census, Compendium Yes 2 intact, hippie 106 257 37 37 0
HSP90AB1 HSP90AB1 P08238 Heat shock protein HSP 90-beta chr6 Census, Compendium Yes 1 intact, hippie 100 254 43 43 0
HSPB1 HSPB1 P04792 Heat shock protein beta-1 chr7 Not Cancer Driver No 1 intact, hippie, biogrid 10 118 8 8 20
INSYN1 INSYN1 Q2T9L4 Inhibitory synaptic factor 1 chr15 Not Cancer Driver No 1 hippie 44 253 41 41 0
JUNB JUNB P17275 Transcription factor JunB chr19 Not Cancer Driver No 1 hippie, biogrid 20 305 16 16 0
KCNE3 KCNE3 Q9Y6H6 Potassium voltage-gated channel subfamily E member 3 chr11 Not Cancer Driver No 1 hippie, biogrid 28 24 2 2 0
KDM4B KDM4B O94953 Lysine-specific demethylase 4B chr19 Not Cancer Driver No 1 hippie, biogrid 133 429 49 49 3
KIF14 KIF14 Q15058 Kinesin-like protein KIF14 chr1 Not Cancer Driver No 1 hippie 222 774 102 102 2
KRAS KRAS P01116 GTPase KRas chr12 Census, Compendium Yes 1 hippie, biogrid 788 7 2 2 27
KTN1 KTN1 Q86UP2 Kinectin chr14 Census Yes 1 intact, hippie 138 964 102 102 0
LAMP1 LAMP1 P11279 Lysosome-associated membrane glycoprotein 1 chr13 Not Cancer Driver No 1 hippie 47 93 10 10 0
LRRK2 LRRK2 Q5S007 Leucine-rich repeat serine/threonine-protein kinase 2 chr12 Not Cancer Driver No 1 intact, hippie 519 90 17 17 23
LSM2 LSM2 Q9Y333 U6 snRNA-associated Sm-like protein LSm2 chr6 Not Cancer Driver No 1 hippie, biogrid 10 3 0 0 0
LSM3 LSM3 P62310 U6 snRNA-associated Sm-like protein LSm3 chr3 Not Cancer Driver No 1 hippie, biogrid 12 28 2 2 0
LSM4 LSM4 Q9Y4Z0 U6 snRNA-associated Sm-like protein LSm4 chr19 Not Cancer Driver No 1 hippie, biogrid 19 64 9 9 0
LSM6_ENST00000502781 LSM6 P62312 U6 snRNA-associated Sm-like protein LSm6 chr4 Not Cancer Driver No 1 hippie, biogrid 7 0 0 0 0
LSM7 LSM7 Q9UK45 U6 snRNA-associated Sm-like protein LSm7 chr19 Not Cancer Driver No 1 hippie, biogrid 5 21 0 0 0
MAP3K2_ENST00000344908 MAP3K2 Q9Y2U5 Mitogen-activated protein kinase kinase kinase 2 chr2 Not Cancer Driver No 1 hippie 75 313 47 47 0
MBOAT7 MBOAT7 Q96N66 Lysophospholipid acyltransferase 7 chr19 Not Cancer Driver No 1 intact, hippie 69 25 3 3 0
MILR1 MILR1 Q7Z6M3 Allergin-1 chr17 Not Cancer Driver No 1 hippie, biogrid 11 60 4 4 0
MOB1B_ENST00000309395 MOB1B Q7L9L4 MOB kinase activator 1B chr4 Not Cancer Driver No 1 hippie, biogrid 17 7 0 0 0
MYC_ENST00000377970 MYC P01106 Myc proto-oncogene protein chr8 Census, Compendium Yes 1 hippie 80 299 46 46 0
MYO9B_ENST00000594824 MYO9B Q13459 Unconventional myosin-IXb chr19 Not Cancer Driver No 1 hippie 226 827 80 80 0
NAA40 NAA40 Q86UY6 N-alpha-acetyltransferase 40 chr11 Not Cancer Driver No 1 hippie 22 30 3 3 0
NCCRP1 NCCRP1 Q6ZVX7 F-box only protein 50 chr19 Not Cancer Driver No 1 intact, hippie, biogrid 38 139 22 22 0
NCK1_ENST00000288986 NCK1 P16333 Cytoplasmic protein NCK1 chr3 Not Cancer Driver No 1 hippie 48 111 17 17 0
NCK2_ENST00000393349 NCK2 O43639 Cytoplasmic protein NCK2 chr2 Not Cancer Driver No 1 hippie 89 88 19 19 0
NEDD4 NEDD4 P46934 E3 ubiquitin-protein ligase NEDD4 chr15 Not Cancer Driver No 1 hippie 150 711 79 79 0
NPRL2 NPRL2 Q8WTW4 GATOR complex protein NPRL2 chr3 Compendium Yes 1 hippie, biogrid 37 10 3 3 1
NRAS NRAS P01111 GTPase NRas chr1 Census, Compendium Yes 1 hippie 284 10 0 0 14
PARD3 PARD3 Q8TEW0 Partitioning defective 3 homolog chr10 Not Cancer Driver No 1 hippie, biogrid 200 1144 170 170 2
PCM1 PCM1 Q15154 Pericentriolar material 1 protein chr8 Census Yes 1 intact, hippie 152 1665 134 134 0
PDK1_ENST00000282077 PDK1 Q15118 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial chr2 Not Cancer Driver No 2 intact, hippie 52 50 10 10 0
PDPK1 PDPK1 O15530 3-phosphoinositide-dependent protein kinase 1 chr16 Not Cancer Driver No 1 hippie 33 121 12 12 0
PHKA2 PHKA2 P46019 Phosphorylase b kinase regulatory subunit alpha, liver isoform chrX Not Cancer Driver No 1 hippie, biogrid 199 193 37 37 17
PKN2 PKN2 Q16513 Serine/threonine-protein kinase N2 chr1 Not Cancer Driver No 2 intact, hippie 123 415 48 48 0
PLCG1_ENST00000373271 PLCG1 P19174 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 chr20 Census, Compendium Yes 1 hippie 158 186 21 21 0
PLEKHA4 PLEKHA4 Q9H4M7 Pleckstrin homology domain-containing family A member 4 chr19 Not Cancer Driver No 1 hippie 136 687 128 128 0
PNMA2 PNMA2 Q9UL42 Paraneoplastic antigen Ma2 chr8 Not Cancer Driver No 2 intact, hippie, biogrid 52 45 5 5 0
PPIAL4G PPIAL4G P0DN37 Peptidyl-prolyl cis-trans isomerase A-like 4G chr1 Not Cancer Driver No 2 intact, hippie, biogrid 48 17 3 3 0
PPIB PPIB P23284 Peptidyl-prolyl cis-trans isomerase B chr15 Not Cancer Driver No 1 intact, hippie 28 16 1 1 1
PPM1B PPM1B O75688 Protein phosphatase 1B chr2 Not Cancer Driver No 1 hippie, biogrid 65 243 31 31 0
PTEN PTEN P60484 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN chr10 Census, Compendium Yes 1 hippie 505 76 4 4 41
PTPN13_ENST00000411767 PTPN13 Q12923 Tyrosine-protein phosphatase non-receptor type 13 chr4 Census, Compendium Yes 1 intact, hippie 299 1231 149 149 0
RABL3 RABL3 Q5HYI8 Rab-like protein 3 chr3 Not Cancer Driver No 1 intact, hippie 37 1 0 0 1
RAC1_ENST00000348035 RAC1 P63000 Ras-related C3 botulinum toxin substrate 1 chr7 Census, Compendium Yes 1 hippie 66 2 1 1 6
RAC2 RAC2 P15153 Ras-related C3 botulinum toxin substrate 2 chr22 Not Cancer Driver No 1 hippie 31 0 0 0 2
RHOA RHOA P61586 Transforming protein RhoA chr3 Census, Compendium Yes 3 hippie, biogrid 99 46 13 13 2
RHOB RHOB P62745 Rho-related GTP-binding protein RhoB chr2 Not Cancer Driver No 2 hippie, biogrid 52 19 2 2 0
RHOC_ENST00000369642 RHOC P08134 Rho-related GTP-binding protein RhoC chr1 Not Cancer Driver No 1 hippie 30 53 7 7 0
RHOD RHOD O00212 Rho-related GTP-binding protein RhoD chr11 Not Cancer Driver No 1 hippie 20 10 0 0 0
RHOF RHOF Q9HBH0 Rho-related GTP-binding protein RhoF chr12 Not Cancer Driver No 1 hippie 18 10 0 0 0
RHOG_ENST00000396978 RHOG P84095 Rho-related GTP-binding protein RhoG chr11 Not Cancer Driver No 1 hippie 26 22 5 5 0
RHOH_ENST00000617441 RHOH Q15669 Rho-related GTP-binding protein RhoH chr4 Census Yes 1 hippie 41 12 3 3 0
RHOJ RHOJ Q9H4E5 Rho-related GTP-binding protein RhoJ chr14 Not Cancer Driver No 1 hippie 39 0 0 0 0
RHOV RHOV Q96L33 Rho-related GTP-binding protein RhoV chr15 Not Cancer Driver No 1 hippie 25 47 5 5 0
RND2 RND2 P52198 Rho-related GTP-binding protein RhoN chr17 Not Cancer Driver No 1 hippie 19 54 4 4 0
RPE RPE Q96AT9 Ribulose-phosphate 3-epimerase chr2 Not Cancer Driver No 1 hippie, biogrid 31 28 6 6 0
RPL35A RPL35A P18077 60S ribosomal protein L35a chr3 Not Cancer Driver No 1 hippie, biogrid 9 25 0 0 1
RPS6KA1_ENST00000374168 RPS6KA1 Q15418 Ribosomal protein S6 kinase alpha-1 chr1 Not Cancer Driver No 1 intact, hippie 94 178 32 32 0
RUFY1 RUFY1 Q96T51 RUN and FYVE domain-containing protein 1 chr5 Not Cancer Driver No 1 intact, hippie 79 356 40 40 0
SERPINB3 SERPINB3 P29508 Serpin B3 chr18 Not Cancer Driver No 1 intact, hippie, biogrid 142 47 28 28 0
SERPINB4 SERPINB4 P48594 Serpin B4 chr18 Not Cancer Driver No 1 hippie, biogrid 120 48 18 18 0
SFN SFN P31947 14-3-3 protein sigma chr1 Not Cancer Driver No 1 hippie, biogrid 27 75 9 9 0
SGPL1 SGPL1 O95470 Sphingosine-1-phosphate lyase 1 chr10 Not Cancer Driver No 1 hippie 68 19 3 3 2
SH3RF1 SH3RF1 Q7Z6J0 E3 ubiquitin-protein ligase SH3RF1 chr4 Not Cancer Driver No 1 hippie 109 586 72 72 0
SKAP1_ENST00000584924 SKAP1 Q86WV1 Src kinase-associated phosphoprotein 1 chr17 Not Cancer Driver No 1 hippie, biogrid 67 130 27 27 0
SNW1_ENST00000261531 SNW1 Q13573 SNW domain-containing protein 1 chr14 Not Cancer Driver No 1 hippie 62 488 56 56 0
SOAT1 SOAT1 P35610 Sterol O-acyltransferase 1 chr1 Not Cancer Driver No 1 intact, hippie 73 49 4 4 0
SUMO2 SUMO2 P61956 Small ubiquitin-related modifier 2 chr17 Not Cancer Driver No 1 hippie 9 69 6 6 0
TANK TANK Q92844 TRAF family member-associated NF-kappa-B activator chr2 Not Cancer Driver No 1 intact, hippie 42 302 26 26 0
TBC1D9 TBC1D9 Q6ZT07 TBC1 domain family member 9 chr4 Not Cancer Driver No 1 hippie, biogrid 196 295 57 57 0
TGFBR2_ENST00000295754 TGFBR2 P37173 TGF-beta receptor type-2 chr3 Census, Compendium Yes 3 intact, hippie, biogrid 106 60 16 16 25
TGM2 TGM2 P21980 Protein-glutamine gamma-glutamyltransferase 2 chr20 Not Cancer Driver No 1 hippie, biogrid 123 107 26 26 0
THBS3 THBS3 P49746 Thrombospondin-3 chr1 Not Cancer Driver No 1 hippie, biogrid 100 283 24 24 0
TMUB1_ENST00000297533 TMUB1 Q9BVT8 Transmembrane and ubiquitin-like domain-containing protein 1 chr7 Not Cancer Driver No 1 intact, hippie 19 128 10 10 0
TRADD TRADD Q15628 Tumor necrosis factor receptor type 1-associated DEATH domain protein chr16 Not Cancer Driver No 1 intact, hippie 26 74 5 5 0
TRAM1 TRAM1 Q15629 Translocating chain-associated membrane protein 1 chr8 Not Cancer Driver No 1 intact, hippie 50 40 4 4 0
TRMT1L TRMT1L Q7Z2T5 TRMT1-like protein chr1 Not Cancer Driver No 1 intact, hippie 71 241 19 19 0
TULP3_ENST00000448120 TULP3 O75386 Tubby-related protein 3 chr12 Not Cancer Driver No 1 hippie 66 218 29 29 0
UBXN6 UBXN6 Q9BZV1 UBX domain-containing protein 6 chr19 Not Cancer Driver No 1 hippie, biogrid 64 132 26 26 0
UNK UNK Q9C0B0 RING finger protein unkempt homolog chr17 Not Cancer Driver No 1 hippie 79 511 46 46 0
USP11 USP11 P51784 Ubiquitin carboxyl-terminal hydrolase 11 chrX Not Cancer Driver No 1 intact, hippie, biogrid 140 210 28 28 0
VAPB VAPB O95292 Vesicle-associated membrane protein-associated protein B/C chr20 Not Cancer Driver No 1 intact, hippie 16 138 8 8 3
VCP VCP P55072 Transitional endoplasmic reticulum ATPase chr9 Not Cancer Driver No 1 hippie 88 186 16 16 16
VIRMA VIRMA Q69YN4 Protein virilizer homolog chr8 Not Cancer Driver No 1 hippie 211 631 93 93 0
VPS33A VPS33A Q96AX1 Vacuolar protein sorting-associated protein 33A chr12 Not Cancer Driver No 1 hippie 73 46 8 8 1
WDR20_ENST00000342702 WDR20 Q8TBZ3 WD repeat-containing protein 20 chr14 Not Cancer Driver No 1 intact, hippie, biogrid 56 209 26 26 0
WDR74_ENST00000278856 WDR74 Q6RFH5 WD repeat-containing protein 74 chr11 Not Cancer Driver No 1 hippie 44 177 21 21 0
ZBTB2 ZBTB2 Q8N680 Zinc finger and BTB domain-containing protein 2 chr6 Not Cancer Driver No 1 hippie, biogrid 75 216 30 30 0
ZNF524_ENST00000301073 ZNF524 Q96C55 Zinc finger protein 524 chr19 Not Cancer Driver No 1 hippie, biogrid 27 182 19 19 0
ZNF747 ZNF747 Q9BV97 Zinc finger protein 747 chr16 Not Cancer Driver No 1 hippie, biogrid 25 192 15 15 0
ZNF785 ZNF785 A8K8V0 Zinc finger protein 785 chr16 Not Cancer Driver No 1 intact, hippie, biogrid 63 105 13 13 0
ZNF8 ZNF8 P17098 Zinc finger protein 8 chr19 Not Cancer Driver No 1 hippie, biogrid 82 407 57 57 0