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PITX2_ENST00000354925 ,PITX2 ,Q99697
  • Uniprot Accession= Q99697
  • Ensembl Transcript= ENST00000354925.6
  • Uniprot Name= PITX2
  • Name= Pituitary homeobox 2
  • Chromosome= chr4
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 23
  • Number of Interaction partner in biogrid: 5
  • Number of Interaction partner in hippie: 70
Identifier
UniProt Gene
UniProt Accession
UniProt Name
Chromosome
Cancer Database
Cancer Driver
Number of independent pubication
Interaction Database
Number of missense mutations
Number of disordered residues
Number of mutations in disordered residues
Number of mutations in disordered residues
Number of omim mutations
AES_ENST00000327141 TLE5 Q08117 TLE family member 5 chr19 Not Cancer Driver No 1 intact 16 77 7 7 0
AHCYL1 AHCYL1 O43865 S-adenosylhomocysteine hydrolase-like protein 1 chr1 Not Cancer Driver No 3 intact, hippie, biogrid 58 108 10 10 0
AHCYL2 AHCYL2 Q96HN2 Adenosylhomocysteinase 3 chr7 Not Cancer Driver No 2 intact, hippie, biogrid 76 208 23 23 0
ANKRD10 ANKRD10 Q9NXR5 Ankyrin repeat domain-containing protein 10 chr13 Not Cancer Driver No 1 intact, hippie 37 181 21 21 0
APEX1_ENST00000555414 APEX1 P27695 DNA-(apurinic or apyrimidinic site) endonuclease chr14 Not Cancer Driver No 1 hippie 34 103 14 14 0
ATN1_ENST00000396684 ATN1 P54259 Atrophin-1 chr12 Not Cancer Driver No 1 intact, hippie 141 1176 139 139 6
CDC37 CDC37 Q16543 Hsp90 co-chaperone Cdc37 chr19 Not Cancer Driver No 1 hippie 52 214 31 31 0
CIC CIC Q96RK0 Protein capicua homolog chr19 Census, Compendium Yes 1 hippie 276 1550 266 266 0
CTNNB1_ENST00000643977 CTNNB1 P35222 Catenin beta-1 chr3 Census, Compendium Yes 1 hippie 415 288 301 301 14
CYSRT1 CYSRT1 B8A4K4 Cysteine-rich tail protein 1 chr9 Not Cancer Driver No 1 intact, hippie 9 142 5 5 0
DAZAP2_ENST00000412716 DAZAP2 Q15038 DAZ-associated protein 2 chr12 Not Cancer Driver No 1 hippie 17 68 7 7 0
DDIT4L DDIT4L Q96D03 DNA damage-inducible transcript 4-like protein chr4 Not Cancer Driver No 1 hippie 48 5 3 3 0
DYNLT1 DYNLT1 P63172 Dynein light chain Tctex-type 1 chr6 Not Cancer Driver No 1 hippie 7 1 0 0 0
EP300 EP300 Q09472 Histone acetyltransferase p300 chr22 Census, Compendium Yes 1 hippie 334 1790 196 196 1
FOXC1_ENST00000645831 FOXC1 Q12948 Forkhead box protein C1 chr6 Not Cancer Driver No 1 hippie 33 411 24 24 32
FOXC2 FOXC2 Q99958 Forkhead box protein C2 chr16 Not Cancer Driver No 1 hippie 63 369 33 33 1
FZR1 FZR1 Q9UM11 Fizzy-related protein homolog chr19 Not Cancer Driver No 1 hippie 74 184 30 30 0
GPR158 GPR158 Q5T848 Probable G-protein coupled receptor 158 chr10 Not Cancer Driver No 1 hippie 374 615 212 212 0
HDAC1 HDAC1 Q13547 Histone deacetylase 1 chr1 Not Cancer Driver No 1 hippie 47 135 10 10 0
HERC5 HERC5 Q9UII4 E3 ISG15--protein ligase HERC5 chr4 Not Cancer Driver No 1 hippie 124 118 12 12 0
HEY1_ENST00000354724 HEY1 Q9Y5J3 Hairy/enhancer-of-split related with YRPW motif protein 1 chr8 Census Yes 1 intact, hippie 33 172 15 15 0
HNRNPK_ENST00000351839 HNRNPK P61978 Heterogeneous nuclear ribonucleoprotein K chr9 Not Cancer Driver No 1 hippie 75 302 59 59 0
HNRNPU HNRNPU Q00839 Heterogeneous nuclear ribonucleoprotein U chr1 Not Cancer Driver No 1 hippie 77 504 45 45 0
HOXA1_ENST00000643460 HOXA1 P49639 Homeobox protein Hox-A1 chr7 Not Cancer Driver No 1 hippie 90 262 68 68 0
HSP90AB1 HSP90AB1 P08238 Heat shock protein HSP 90-beta chr6 Census, Compendium Yes 1 hippie 100 254 43 43 0
HSPA8_ENST00000532636 HSPA8 P11142 Heat shock cognate 71 kDa protein chr11 Not Cancer Driver No 1 hippie 149 251 52 52 0
IER2_ENST00000587885 IER2 Q9BTL4 Immediate early response gene 2 protein chr19 Not Cancer Driver No 3 hippie, biogrid 16 178 13 13 0
KAT5_ENST00000377046 KAT5 Q92993 Histone acetyltransferase KAT5 chr11 Not Cancer Driver No 1 hippie 65 173 21 21 3
KRT34 KRT34 O76011 Keratin, type I cuticular Ha4 chr17 Not Cancer Driver No 1 hippie 102 58 21 21 0
KRTAP15-1 KRTAP15-1 Q3LI76 Keratin-associated protein 15-1 chr21 Not Cancer Driver No 1 intact, hippie 41 0 0 0 0
KRTAP19-5 KRTAP19-5 Q3LI72 Keratin-associated protein 19-5 chr21 Not Cancer Driver No 1 intact, hippie 35 0 0 0 0
KRTAP19-7 KRTAP19-7 Q3SYF9 Keratin-associated protein 19-7 chr21 Not Cancer Driver No 1 intact, hippie 20 0 0 0 0
KRTAP3-3 KRTAP3-3 Q9BYR6 Keratin-associated protein 3-3 chr17 Not Cancer Driver No 1 intact, hippie 19 0 0 0 0
KRTAP6-1 KRTAP6-1 Q3LI64 Keratin-associated protein 6-1 chr21 Not Cancer Driver No 1 intact, hippie 27 0 0 0 0
KRTAP7-1 KRTAP7-1 Q8IUC3 Keratin-associated protein 7-1 chr21 Not Cancer Driver No 1 hippie 3 0 0 0 0
LEF1 LEF1 Q9UJU2 Lymphoid enhancer-binding factor 1 chr4 Census Yes 1 hippie 64 370 57 57 0
LRRC46 LRRC46 Q96FV0 Leucine-rich repeat-containing protein 46 chr17 Not Cancer Driver No 3 intact, hippie, biogrid 40 159 20 20 0
MEF2A_ENST00000354410 MEF2A Q02078 Myocyte-specific enhancer factor 2A chr15 Not Cancer Driver No 1 hippie 62 454 56 56 0
MYC_ENST00000377970 MYC P01106 Myc proto-oncogene protein chr8 Census, Compendium Yes 1 hippie 80 299 46 46 0
NCL NCL P19338 Nucleolin chr2 Not Cancer Driver No 1 hippie 85 569 68 68 0
NOP2_ENST00000322166 NOP2 P46087 Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase chr12 Not Cancer Driver No 1 hippie, biogrid 116 510 72 72 0
OIP5 OIP5 O43482 Protein Mis18-beta chr15 Not Cancer Driver No 1 hippie 31 65 7 7 0
PDLIM1 PDLIM1 O00151 PDZ and LIM domain protein 1 chr10 Not Cancer Driver No 1 hippie 62 219 39 39 0
PFDN5 PFDN5 Q99471 Prefoldin subunit 5 chr12 Not Cancer Driver No 1 hippie 18 3 0 0 0
PITX2_ENST00000354925 PITX2 Q99697 Pituitary homeobox 2 chr4 Not Cancer Driver No 1 hippie 74 185 43 43 13
POU2AF1 POU2AF1 Q16633 POU domain class 2-associating factor 1 chr11 Census Yes 1 intact, hippie 59 181 45 45 0
PRKACB_ENST00000370689 PRKACB P22694 cAMP-dependent protein kinase catalytic subunit beta chr1 Not Cancer Driver No 1 hippie 50 26 6 6 4
PROP1 PROP1 O75360 Homeobox protein prophet of Pit-1 chr5 Not Cancer Driver No 1 hippie 35 194 32 32 7
PSMB4 PSMB4 P28070 Proteasome subunit beta type-4 chr1 Not Cancer Driver No 1 intact, hippie 23 18 2 2 0
RBPJ_ENST00000361572 RBPJ Q06330 Recombining binding protein suppressor of hairless chr4 Not Cancer Driver No 1 hippie 49 151 19 19 2
RBPMS_ENST00000320203 RBPMS Q93062 RNA-binding protein with multiple splicing chr8 Not Cancer Driver No 1 intact, hippie 23 87 11 11 0
RFC2 RFC2 P35250 Replication factor C subunit 2 chr7 Not Cancer Driver No 1 hippie 45 39 6 6 0
SMAD3 SMAD3 P84022 Mothers against decapentaplegic homolog 3 chr15 Census, Compendium Yes 1 hippie 97 111 19 19 5
SMUG1 SMUG1 Q53HV7 Single-strand selective monofunctional uracil DNA glycosylase chr12 Not Cancer Driver No 1 intact, hippie 33 46 2 2 0
TBX22 TBX22 Q9Y458 T-box transcription factor TBX22 chrX Not Cancer Driver No 1 intact, hippie 163 202 64 64 6
TEX37 TEX37 Q96LM6 Testis-expressed sequence 37 protein chr2 Not Cancer Driver No 1 intact, hippie 40 112 26 26 0
TINAGL1 TINAGL1 Q9GZM7 Tubulointerstitial nephritis antigen-like chr1 Not Cancer Driver No 1 hippie 62 89 15 15 0
TRAF1 TRAF1 Q13077 TNF receptor-associated factor 1 chr9 Not Cancer Driver No 1 intact, hippie 51 63 9 9 0
TRIB3_ENST00000217233 TRIB3 Q96RU7 Tribbles homolog 3 chr20 Not Cancer Driver No 1 hippie 65 114 24 24 0
TRIM25 TRIM25 Q14258 E3 ubiquitin/ISG15 ligase TRIM25 chr17 Not Cancer Driver No 1 hippie 59 225 20 20 0
UFSP1 UFSP1 Q6NVU6 Inactive Ufm1-specific protease 1 chr7 Not Cancer Driver No 1 intact, hippie 13 13 2 2 0
VGLL3 VGLL3 A8MV65 Transcription cofactor vestigial-like protein 3 chr3 Not Cancer Driver No 1 intact, hippie 98 273 85 85 0
WDR5 WDR5 P61964 WD repeat-containing protein 5 chr9 Not Cancer Driver No 1 hippie 30 35 3 3 0
WNT2 WNT2 P09544 Protein Wnt-2 chr7 Not Cancer Driver No 1 hippie 85 11 3 3 0
WNT2B WNT2B Q93097 Protein Wnt-2b chr1 Not Cancer Driver No 1 hippie 72 27 3 3 0
WNT5A_ENST00000474267 WNT5A P41221 Protein Wnt-5a chr3 Not Cancer Driver No 1 hippie 66 0 0 0 2
WNT6 WNT6 Q9Y6F9 Protein Wnt-6 chr2 Not Cancer Driver No 1 hippie 30 84 9 9 0
WNT9A WNT9A O14904 Protein Wnt-9a chr1 Not Cancer Driver No 1 hippie 74 44 11 11 0
WWOX WWOX Q9NZC7 WW domain-containing oxidoreductase chr16 Not Cancer Driver No 1 intact, hippie 79 108 9 9 3
YBX1 YBX1 P67809 Y-box-binding protein 1 chr1 Not Cancer Driver No 1 hippie 41 312 41 41 0
ZNF34 ZNF34 Q8IZ26 Zinc finger protein 34 chr8 Not Cancer Driver No 1 hippie 62 221 23 23 0