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PIP5K1A ,PIP5K1A ,Q99755
  • Uniprot Accession= Q99755
  • Ensembl Transcript= ENST00000368888.8
  • Uniprot Name= PIP5K1A
  • Name= Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 23
  • Number of Interaction partner in biogrid: 80
  • Number of Interaction partner in hippie: 132
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ABT1 ABT1 Q9ULW3 Activator of basal transcription 1 chr6 Not Cancer Driver No 1 hippie, biogrid 56 157 30 30 0
AGRN AGRN O00468 Agrin chr1 Not Cancer Driver No 1 hippie 188 490 40 40 5
AHCYL2 AHCYL2 Q96HN2 Adenosylhomocysteinase 3 chr7 Not Cancer Driver No 2 intact, hippie, biogrid 76 208 23 23 0
APBA1 APBA1 Q02410 Amyloid-beta A4 precursor protein-binding family A member 1 chr9 Not Cancer Driver No 1 hippie, biogrid 149 556 103 103 0
APP APP P05067 Amyloid-beta precursor protein chr21 Not Cancer Driver No 1 hippie 128 418 71 71 17
ARF1_ENST00000272102 ARF1 P84077 ADP-ribosylation factor 1 chr1 Not Cancer Driver No 1 hippie 30 4 2 2 2
ARF5 ARF5 P84085 ADP-ribosylation factor 5 chr7 Not Cancer Driver No 1 hippie 22 11 2 2 0
ARF6 ARF6 P62330 ADP-ribosylation factor 6 chr14 Not Cancer Driver No 2 hippie, biogrid 18 5 0 0 0
ARHGAP22_ENST00000249601 ARHGAP22 Q7Z5H3 Rho GTPase-activating protein 22 chr10 Not Cancer Driver No 2 intact, hippie, biogrid 138 449 90 90 0
ARIH1 ARIH1 Q9Y4X5 E3 ubiquitin-protein ligase ARIH1 chr15 Not Cancer Driver No 3 hippie, biogrid 46 119 7 7 0
ARL14 ARL14 Q8N4G2 ADP-ribosylation factor-like protein 14 chr3 Not Cancer Driver No 1 intact, hippie 27 15 2 2 0
BRAF BRAF P15056 Serine/threonine-protein kinase B-raf chr7 Census, Compendium Yes 1 hippie 791 310 43 43 39
BTK_ENST00000308731 BTK Q06187 Tyrosine-protein kinase BTK chrX Census, Compendium Yes 1 hippie 147 114 27 27 110
C11orf52 C11orf52 Q96A22 Uncharacterized protein C11orf52 chr11 Not Cancer Driver No 1 hippie, biogrid 15 108 12 12 0
CADPS CADPS Q9ULU8 Calcium-dependent secretion activator 1 chr3 Not Cancer Driver No 1 hippie 298 336 71 71 0
CAMK2A_ENST00000348628 CAMK2A Q9UQM7 Calcium/calmodulin-dependent protein kinase type II subunit alpha chr5 Not Cancer Driver No 1 hippie, biogrid 83 62 10 10 7
CAMK2D_ENST00000342666 CAMK2D Q13557 Calcium/calmodulin-dependent protein kinase type II subunit delta chr4 Not Cancer Driver No 2 intact, hippie, biogrid 57 84 10 10 0
CAPN2 CAPN2 P17655 Calpain-2 catalytic subunit chr1 Not Cancer Driver No 1 hippie, biogrid 81 46 11 11 0
CASP3 CASP3 P42574 Caspase-3 chr4 Census Yes 1 hippie 32 62 5 5 0
CAV1 CAV1 Q03135 Caveolin-1 chr7 Not Cancer Driver No 1 hippie, biogrid 30 2 0 0 0
CCDC85A CCDC85A Q96PX6 Coiled-coil domain-containing protein 85A chr2 Not Cancer Driver No 1 hippie, biogrid 146 399 116 116 0
CCDC97 CCDC97 Q96F63 Coiled-coil domain-containing protein 97 chr19 Not Cancer Driver No 2 intact, hippie, biogrid 59 251 41 41 0
CD6 CD6 P30203 T-cell differentiation antigen CD6 chr11 Not Cancer Driver No 1 hippie, biogrid 91 268 41 41 0
CENPB CENPB P07199 Major centromere autoantigen B chr20 Not Cancer Driver No 1 hippie, biogrid 64 374 39 39 0
CSNK1A1_ENST00000377843 CSNK1A1 P48729 Casein kinase I isoform alpha chr5 Not Cancer Driver No 1 hippie, biogrid 44 46 3 3 0
CXADR CXADR P78310 Coxsackievirus and adenovirus receptor chr21 Not Cancer Driver No 1 hippie, biogrid 51 98 19 19 0
DCAF5 DCAF5 Q96JK2 DDB1- and CUL4-associated factor 5 chr14 Not Cancer Driver No 2 intact, hippie, biogrid 119 521 80 80 0
DGKZ_ENST00000456247 DGKZ Q13574 Diacylglycerol kinase zeta chr11 Not Cancer Driver No 1 hippie, biogrid 87 410 42 42 0
DNAJA2 DNAJA2 O60884 DnaJ homolog subfamily A member 2 chr16 Not Cancer Driver No 1 hippie, biogrid 50 174 27 27 0
DNAJC5 DNAJC5 Q9H3Z4 DnaJ homolog subfamily C member 5 chr20 Not Cancer Driver No 1 hippie, biogrid 23 46 6 6 1
EGFR EGFR P00533 Epidermal growth factor receptor chr7 Census, Compendium Yes 1 hippie 444 223 35 35 1
FLNC FLNC Q14315 Filamin-C chr7 Not Cancer Driver No 1 hippie, biogrid 546 1442 288 288 7
FRYL FRYL O94915 Protein furry homolog-like chr4 Not Cancer Driver No 1 hippie, biogrid 366 666 79 79 0
FTL FTL P02792 Ferritin light chain chr19 Not Cancer Driver No 1 hippie, biogrid 19 36 7 7 2
FZR1 FZR1 Q9UM11 Fizzy-related protein homolog chr19 Not Cancer Driver No 1 hippie 74 184 30 30 0
GCH1_ENST00000622544 GCH1 P30793 GTP cyclohydrolase 1 chr14 Not Cancer Driver No 1 hippie, biogrid 20 99 5 5 38
GFOD1 GFOD1 Q9NXC2 Glucose-fructose oxidoreductase domain-containing protein 1 chr6 Not Cancer Driver No 3 hippie, biogrid 57 35 2 2 0
GJA1 GJA1 P17302 Gap junction alpha-1 protein chr6 Not Cancer Driver No 1 hippie, biogrid 86 110 26 26 50
GPC3_ENST00000370818 GPC3 P51654 Glypican-3 chrX Census Yes 2 hippie, biogrid 89 86 11 11 1
GPR156_ENST00000315843 GPR156 Q8NFN8 Probable G-protein coupled receptor 156 chr3 Not Cancer Driver No 2 hippie, biogrid 131 417 74 74 0
HEATR3 HEATR3 Q7Z4Q2 HEAT repeat-containing protein 3 chr16 Not Cancer Driver No 1 hippie, biogrid 73 134 10 10 0
HECW2_ENST00000644256 HECW2 Q9P2P5 E3 ubiquitin-protein ligase HECW2 chr2 Not Cancer Driver No 1 hippie 348 845 195 195 4
HEXIM1 HEXIM1 O94992 Protein HEXIM1 chr17 Not Cancer Driver No 1 hippie 40 352 40 40 0
HNRNPH1 HNRNPH1 P31943 Heterogeneous nuclear ribonucleoprotein H chr5 Not Cancer Driver No 1 hippie 51 169 29 29 0
HNRNPL HNRNPL P14866 Heterogeneous nuclear ribonucleoprotein L chr19 Not Cancer Driver No 1 hippie 89 283 29 29 0
HRAS HRAS P01112 GTPase HRas chr11 Census, Compendium Yes 1 intact, hippie, biogrid 107 16 4 4 18
HTATSF1_ENST00000218364 HTATSF1 O43719 HIV Tat-specific factor 1 chrX Not Cancer Driver No 1 hippie, biogrid 131 573 100 100 0
IMPDH1_ENST00000626419 IMPDH1 P20839 Inosine-5'-monophosphate dehydrogenase 1 chr7 Not Cancer Driver No 2 hippie, biogrid 75 13 1 1 7
IMPDH2 IMPDH2 P12268 Inosine-5'-monophosphate dehydrogenase 2 chr3 Not Cancer Driver No 1 hippie, biogrid 70 6 1 1 0
ITGB1BP2 ITGB1BP2 Q9UKP3 Integrin beta-1-binding protein 2 chrX Not Cancer Driver No 1 hippie 51 137 22 22 0
KBTBD7 KBTBD7 Q8WVZ9 Kelch repeat and BTB domain-containing protein 7 chr13 Not Cancer Driver No 2 intact, hippie, biogrid 92 105 6 6 0
KCNJ2_ENST00000535240 KCNJ2 P63252 Inward rectifier potassium channel 2 chr17 Not Cancer Driver No 1 hippie 103 49 11 11 12
KCTD17 KCTD17 Q8N5Z5 BTB/POZ domain-containing protein KCTD17 chr22 Not Cancer Driver No 3 intact, hippie, biogrid 23 187 14 14 1
KLHDC3 KLHDC3 Q9BQ90 Kelch domain-containing protein 3 chr6 Not Cancer Driver No 2 hippie, biogrid 43 12 1 1 0
KRAS KRAS P01116 GTPase KRas chr12 Census, Compendium Yes 2 intact, hippie, biogrid 788 7 2 2 27
KSR1_ENST00000644974 KSR1 Q8IVT5 Kinase suppressor of Ras 1 chr17 Not Cancer Driver No 1 intact, hippie 114 404 58 58 0
LAMP1 LAMP1 P11279 Lysosome-associated membrane glycoprotein 1 chr13 Not Cancer Driver No 1 hippie, biogrid 47 93 10 10 0
LAMP2_ENST00000200639 LAMP2 P13473 Lysosome-associated membrane glycoprotein 2 chrX Not Cancer Driver No 1 hippie, biogrid 43 55 7 7 1
LAMTOR1 LAMTOR1 Q6IAA8 Ragulator complex protein LAMTOR1 chr11 Not Cancer Driver No 1 hippie, biogrid 13 96 7 7 0
LARP7_ENST00000344442 LARP7 Q4G0J3 La-related protein 7 chr4 Not Cancer Driver No 1 hippie 58 350 44 44 0
LRRK2 LRRK2 Q5S007 Leucine-rich repeat serine/threonine-protein kinase 2 chr12 Not Cancer Driver No 1 intact, hippie 519 90 17 17 23
LYN LYN P07948 Tyrosine-protein kinase Lyn chr8 Census Yes 1 hippie, biogrid 95 84 12 12 0
MAGEB2 MAGEB2 O15479 Melanoma-associated antigen B2 chrX Not Cancer Driver No 1 hippie, biogrid 98 126 35 35 0
MAP1LC3B MAP1LC3B Q9GZQ8 Microtubule-associated proteins 1A/1B light chain 3B chr16 Not Cancer Driver No 1 hippie 10 17 1 1 0
MAP4K2 MAP4K2 Q12851 Mitogen-activated protein kinase kinase kinase kinase 2 chr11 Not Cancer Driver No 1 hippie 78 243 23 23 0
MARCKS MARCKS P29966 Myristoylated alanine-rich C-kinase substrate chr6 Not Cancer Driver No 1 hippie, biogrid 14 328 14 14 0
MED4 MED4 Q9NPJ6 Mediator of RNA polymerase II transcription subunit 4 chr13 Not Cancer Driver No 1 hippie 29 161 17 17 0
MOV10_ENST00000357443 MOV10 Q9HCE1 Helicase MOV-10 chr1 Not Cancer Driver No 1 hippie 110 101 8 8 0
MTMR4 MTMR4 Q9NYA4 Myotubularin-related protein 4 chr17 Not Cancer Driver No 1 hippie 147 474 59 59 0
MYH9 MYH9 P35579 Myosin-9 chr22 Census, Compendium Yes 1 intact, hippie 310 1120 160 160 17
NEDD4 NEDD4 P46934 E3 ubiquitin-protein ligase NEDD4 chr15 Not Cancer Driver No 1 hippie 150 711 79 79 0
NHLRC2 NHLRC2 Q8NBF2 NHL repeat-containing protein 2 chr10 Not Cancer Driver No 1 hippie 74 103 12 12 0
NRAS NRAS P01111 GTPase NRas chr1 Census, Compendium Yes 1 hippie 284 10 0 0 14
NRP1 NRP1 O14786 Neuropilin-1 chr10 Compendium Yes 2 hippie, biogrid 146 211 31 31 0
NRXN3_ENST00000557594 NRXN3 Q9HDB5 Neurexin-3-beta chr14 Not Cancer Driver No 2 intact, hippie, biogrid 110 382 61 61 0
NXF1_ENST00000294172 NXF1 Q9UBU9 Nuclear RNA export factor 1 chr11 Compendium Yes 1 hippie 100 163 32 32 0
PELP1_ENST00000574876 PELP1 Q8IZL8 Proline-, glutamic acid- and leucine-rich protein 1 chr17 Not Cancer Driver No 1 hippie, biogrid 134 610 82 82 0
PER2 PER2 O15055 Period circadian protein homolog 2 chr2 Not Cancer Driver No 1 hippie, biogrid 166 782 101 101 1
PFDN2 PFDN2 Q9UHV9 Prefoldin subunit 2 chr1 Not Cancer Driver No 2 hippie, biogrid 18 111 11 11 0
PGBD5 PGBD5 Q8N414 PiggyBac transposable element-derived protein 5 chr1 Not Cancer Driver No 1 hippie, biogrid 73 126 1 1 0
PIP4K2A PIP4K2A P48426 Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha chr10 Not Cancer Driver No 2 intact, hippie, biogrid 56 123 15 15 0
PIP5K1C_ENST00000335312 PIP5K1C O60331 Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma chr19 Not Cancer Driver No 2 intact, hippie, biogrid 98 360 60 60 1
PIP5KL1 PIP5KL1 Q5T9C9 Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 chr9 Not Cancer Driver No 1 hippie 28 74 6 6 0
PLD1 PLD1 Q13393 Phospholipase D1 chr3 Not Cancer Driver No 1 hippie 181 133 32 32 1
PLD2 PLD2 O14939 Phospholipase D2 chr17 Not Cancer Driver No 1 hippie 107 97 8 8 0
PLXDC2 PLXDC2 Q6UX71 Plexin domain-containing protein 2 chr10 Not Cancer Driver No 1 hippie, biogrid 151 150 50 50 0
PREX1 PREX1 Q8TCU6 Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein chr20 Not Cancer Driver No 1 hippie, biogrid 297 307 55 55 0
PRKCA PRKCA P17252 Protein kinase C alpha type chr17 Not Cancer Driver No 2 intact, hippie, biogrid 94 154 22 22 0
PRPS2_ENST00000380668 PRPS2 P11908 Ribose-phosphate pyrophosphokinase 2 chrX Not Cancer Driver No 1 hippie, biogrid 56 4 1 1 0
PTGES3_ENST00000262033 PTGES3 Q15185 Prostaglandin E synthase 3 chr12 Not Cancer Driver No 1 hippie, biogrid 11 52 3 3 0
RAB2A RAB2A P61019 Ras-related protein Rab-2A chr8 Not Cancer Driver No 1 hippie, biogrid 22 58 4 4 0
RAB35 RAB35 Q15286 Ras-related protein Rab-35 chr12 Not Cancer Driver No 1 hippie, biogrid 25 25 2 2 0
RABGGTB RABGGTB P53611 Geranylgeranyl transferase type-2 subunit beta chr1 Not Cancer Driver No 3 hippie, biogrid 50 4 1 1 0
RAC1_ENST00000348035 RAC1 P63000 Ras-related C3 botulinum toxin substrate 1 chr7 Census, Compendium Yes 1 hippie 66 2 1 1 6
RAC2 RAC2 P15153 Ras-related C3 botulinum toxin substrate 2 chr22 Not Cancer Driver No 1 hippie 31 0 0 0 2
RAC3 RAC3 P60763 Ras-related C3 botulinum toxin substrate 3 chr17 Not Cancer Driver No 1 hippie 24 0 0 0 4
RAD21 RAD21 O60216 Double-strand-break repair protein rad21 homolog chr8 Census, Compendium Yes 2 intact, hippie, biogrid 115 421 74 74 3
RC3H1_ENST00000258349 RC3H1 Q5TC82 Roquin-1 chr1 Not Cancer Driver No 1 hippie 158 796 115 115 0
RECQL4 RECQL4 O94761 ATP-dependent DNA helicase Q4 chr8 Census, Compendium Yes 1 hippie 138 608 71 71 1
RHOB RHOB P62745 Rho-related GTP-binding protein RhoB chr2 Not Cancer Driver No 1 hippie, biogrid 52 19 2 2 0
RHOF RHOF Q9HBH0 Rho-related GTP-binding protein RhoF chr12 Not Cancer Driver No 1 hippie 18 10 0 0 0
RHOG_ENST00000396978 RHOG P84095 Rho-related GTP-binding protein RhoG chr11 Not Cancer Driver No 1 hippie 26 22 5 5 0
RHOJ RHOJ Q9H4E5 Rho-related GTP-binding protein RhoJ chr14 Not Cancer Driver No 1 hippie 39 0 0 0 0
RHOQ RHOQ P17081 Rho-related GTP-binding protein RhoQ chr2 Not Cancer Driver No 1 hippie 25 0 0 0 0
RHOU RHOU Q7L0Q8 Rho-related GTP-binding protein RhoU chr1 Not Cancer Driver No 1 hippie 34 63 6 6 0
RPL10_ENST00000369817 RPL10 P27635 60S ribosomal protein L10 chrX Census, Compendium Yes 1 intact, hippie 46 9 3 3 4
RPS16 RPS16 P62249 40S ribosomal protein S16 chr19 Not Cancer Driver No 1 hippie, biogrid 16 14 1 1 0
RUNDC3A RUNDC3A Q59EK9 RUN domain-containing protein 3A chr17 Not Cancer Driver No 1 hippie, biogrid 39 175 8 8 0
SERBP1 SERBP1 Q8NC51 Plasminogen activator inhibitor 1 RNA-binding protein chr1 Not Cancer Driver No 1 hippie 53 408 53 53 0
SIRT1 SIRT1 Q96EB6 NAD-dependent protein deacetylase sirtuin-1 chr10 Not Cancer Driver No 1 hippie 70 435 31 31 0
SKAP1_ENST00000584924 SKAP1 Q86WV1 Src kinase-associated phosphoprotein 1 chr17 Not Cancer Driver No 1 hippie, biogrid 67 130 27 27 0
SMURF1 SMURF1 Q9HCE7 E3 ubiquitin-protein ligase SMURF1 chr7 Not Cancer Driver No 1 hippie 89 256 31 31 0
SNAPC1 SNAPC1 Q16533 snRNA-activating protein complex subunit 1 chr14 Not Cancer Driver No 1 hippie, biogrid 36 158 16 16 0
SNAPC3_ENST00000610884 SNAPC3 Q92966 snRNA-activating protein complex subunit 3 chr9 Not Cancer Driver No 1 hippie, biogrid 30 99 2 2 0
SNAPC4 SNAPC4 Q5SXM2 snRNA-activating protein complex subunit 4 chr9 Not Cancer Driver No 1 hippie, biogrid 143 1094 96 96 0
SNRNP70 SNRNP70 P08621 U1 small nuclear ribonucleoprotein 70 kDa chr19 Not Cancer Driver No 1 hippie 38 416 37 37 0
SRSF6 SRSF6 Q13247 Serine/arginine-rich splicing factor 6 chr20 Not Cancer Driver No 1 hippie, biogrid 69 259 49 49 0
STAG2_ENST00000371157 STAG2 Q8N3U4 Cohesin subunit SA-2 chrX Census, Compendium Yes 2 intact, hippie, biogrid 179 330 46 46 3
STX7 STX7 O15400 Syntaxin-7 chr6 Not Cancer Driver No 1 hippie, biogrid 29 164 14 14 0
TEC TEC P42680 Tyrosine-protein kinase Tec chr4 Census, Compendium Yes 1 hippie 91 57 15 15 0
TGFBR3_ENST00000525962 TGFBR3 Q03167 Transforming growth factor beta receptor type 3 chr1 Not Cancer Driver No 2 intact, hippie, biogrid 129 268 41 41 0
TMED9 TMED9 Q9BVK6 Transmembrane emp24 domain-containing protein 9 chr5 Not Cancer Driver No 1 hippie, biogrid 16 22 2 2 0
TRIM25 TRIM25 Q14258 E3 ubiquitin/ISG15 ligase TRIM25 chr17 Not Cancer Driver No 1 hippie 59 225 20 20 0
TRIM41 TRIM41 Q8WV44 E3 ubiquitin-protein ligase TRIM41 chr5 Not Cancer Driver No 2 intact, hippie, biogrid 69 385 38 38 0
TUT1_ENST00000476907 TUT1 Q9H6E5 Speckle targeted PIP5K1A-regulated poly(A) polymerase chr11 Not Cancer Driver No 1 intact, hippie 97 410 50 50 0
UBD UBD O15205 Ubiquitin D chr6 Not Cancer Driver No 1 hippie 31 8 1 1 0
ZBTB7C_ENST00000590800 ZBTB7C A1YPR0 Zinc finger and BTB domain-containing protein 7C chr18 Not Cancer Driver No 1 hippie, biogrid 91 249 40 40 0
ZC3H18_ENST00000301011 ZC3H18 Q86VM9 Zinc finger CCCH domain-containing protein 18 chr16 Not Cancer Driver No 2 hippie, biogrid 139 929 134 134 0
ZKSCAN8_ENST00000457389 ZKSCAN8 Q15776 Zinc finger protein with KRAB and SCAN domains 8 chr6 Not Cancer Driver No 1 hippie, biogrid 70 280 38 38 0
ZNF467 ZNF467 Q7Z7K2 Zinc finger protein 467 chr7 Not Cancer Driver No 1 hippie, biogrid 75 345 37 37 0
ZNF653 ZNF653 Q96CK0 Zinc finger protein 653 chr19 Not Cancer Driver No 1 hippie, biogrid 78 371 45 45 0
ZSCAN31 ZSCAN31 Q96LW9 Zinc finger and SCAN domain-containing protein 31 chr6 Not Cancer Driver No 2 hippie, biogrid 71 192 33 33 0