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PCSK9 ,PCSK9 ,Q8NBP7
  • Number of Interaction partner in intact: 2
  • Number of Interaction partner in biogrid: 44
  • Number of Interaction partner in hippie: 75
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
AC244197.3 IDS B3KWA1 Iduronate 2-sulfatase (Hunter syndrome), isoform CRA_e chrX Not Cancer Driver No 1 hippie, biogrid 57 21 3 3 0
ADAM18 ADAM18 Q9Y3Q7 Disintegrin and metalloproteinase domain-containing protein 18 chr8 Not Cancer Driver No 1 hippie, biogrid 224 4 2 2 0
ADAMTS4 ADAMTS4 O75173 A disintegrin and metalloproteinase with thrombospondin motifs 4 chr1 Not Cancer Driver No 1 hippie, biogrid 134 159 27 27 0
AGK AGK Q53H12 Acylglycerol kinase, mitochondrial chr7 Not Cancer Driver No 1 hippie 71 77 6 6 0
ALPP ALPP P05187 Alkaline phosphatase, placental type chr2 Not Cancer Driver No 1 hippie, biogrid 120 161 40 40 0
ANXA2_ENST00000396024 ANXA2 P07355 Annexin A2 chr15 Not Cancer Driver No 1 hippie 49 20 4 4 0
ARMC6 ARMC6 Q6NXE6 Armadillo repeat-containing protein 6 chr19 Not Cancer Driver No 1 hippie 65 77 5 5 0
BACE1 BACE1 P56817 Beta-secretase 1 chr11 Not Cancer Driver No 1 hippie 55 53 5 5 0
BIRC2 BIRC2 Q13490 Baculoviral IAP repeat-containing protein 2 chr11 Not Cancer Driver No 1 hippie 69 83 9 9 0
C1QB C1QB P02746 Complement C1q subcomponent subunit B chr1 Not Cancer Driver No 1 hippie, biogrid 46 133 31 31 1
C1orf54 C1orf54 Q8WWF1 Uncharacterized protein C1orf54 chr1 Not Cancer Driver No 1 hippie, biogrid 17 28 3 3 0
CA6_ENST00000377443 CA6 P23280 Carbonic anhydrase 6 chr1 Not Cancer Driver No 1 hippie, biogrid 50 56 5 5 0
CBLN4 CBLN4 Q9NTU7 Cerebellin-4 chr20 Not Cancer Driver No 1 hippie, biogrid 62 20 10 10 0
CDIPT_ENST00000569956 CDIPT O14735 CDP-diacylglycerol--inositol 3-phosphatidyltransferase chr16 Not Cancer Driver No 1 hippie 21 0 0 0 0
CLEC4C_ENST00000360345 CLEC4C Q8WTT0 C-type lectin domain family 4 member C chr12 Not Cancer Driver No 1 hippie, biogrid 58 5 1 1 0
CLGN_ENST00000414773 CLGN O14967 Calmegin chr4 Not Cancer Driver No 1 hippie 86 255 36 36 0
CRISP2_ENST00000616725 CRISP2 P16562 Cysteine-rich secretory protein 2 chr6 Not Cancer Driver No 1 hippie, biogrid 65 46 11 11 0
DNAJA1 DNAJA1 P31689 DnaJ homolog subfamily A member 1 chr9 Not Cancer Driver No 1 hippie 37 153 16 16 0
DNAJA2 DNAJA2 O60884 DnaJ homolog subfamily A member 2 chr16 Not Cancer Driver No 1 hippie 50 174 27 27 0
DNAJA3 DNAJA3 Q96EY1 DnaJ homolog subfamily A member 3, mitochondrial chr16 Not Cancer Driver No 1 hippie 50 152 21 21 0
DNAJB11_ENST00000265028 DNAJB11 Q9UBS4 DnaJ homolog subfamily B member 11 chr3 Not Cancer Driver No 1 hippie 52 141 21 21 2
DNAJC10 DNAJC10 Q8IXB1 DnaJ homolog subfamily C member 10 chr2 Not Cancer Driver No 1 hippie 110 36 3 3 0
DNASE1L1 DNASE1L1 P49184 Deoxyribonuclease-1-like 1 chrX Not Cancer Driver No 1 hippie, biogrid 30 0 0 0 0
DPEP2_ENST00000393847 DPEP2 Q9H4A9 Dipeptidase 2 chr16 Not Cancer Driver No 1 hippie, biogrid 66 73 4 4 0
EDN3_ENST00000371028 EDN3 P14138 Endothelin-3 chr20 Not Cancer Driver No 1 hippie, biogrid 69 140 44 44 3
ELSPBP1 ELSPBP1 Q96BH3 Epididymal sperm-binding protein 1 chr19 Not Cancer Driver No 1 hippie, biogrid 54 0 0 0 0
EPHA7 EPHA7 Q15375 Ephrin type-A receptor 7 chr6 Census, Compendium Yes 1 hippie, biogrid 280 71 15 15 0
FAM20C FAM20C Q8IXL6 Extracellular serine/threonine protein kinase FAM20C chr7 Not Cancer Driver No 1 hippie 33 188 3 3 9
FCGR3B_ENST00000367964 FCGR3B O75015 Low affinity immunoglobulin gamma Fc region receptor III-B chr1 Not Cancer Driver No 1 hippie, biogrid 58 0 0 0 0
FCN3 FCN3 O75636 Ficolin-3 chr1 Not Cancer Driver No 1 hippie, biogrid 46 65 19 19 0
FIBIN FIBIN Q8TAL6 Fin bud initiation factor homolog chr11 Not Cancer Driver No 1 hippie, biogrid 42 51 12 12 0
FSTL4 FSTL4 Q6MZW2 Follistatin-related protein 4 chr5 Not Cancer Driver No 1 hippie, biogrid 134 96 12 12 0
GGH GGH Q92820 Gamma-glutamyl hydrolase chr8 Not Cancer Driver No 1 hippie, biogrid 46 5 0 0 0
HSPB1 HSPB1 P04792 Heat shock protein beta-1 chr7 Not Cancer Driver No 1 hippie 10 118 8 8 20
IDS IDS P22304 Iduronate 2-sulfatase chrX Not Cancer Driver No 1 hippie, biogrid 91 85 13 13 126
IGLL5 IGLL5 B9A064 Immunoglobulin lambda-like polypeptide 5 chr22 Not Cancer Driver No 1 hippie, biogrid 59 127 35 35 0
IL12RB1_ENST00000593993 IL12RB1 P42701 Interleukin-12 receptor subunit beta-1 chr19 Not Cancer Driver No 1 hippie, biogrid 108 207 38 38 1
IL5RA_ENST00000256452 IL5RA Q01344 Interleukin-5 receptor subunit alpha chr3 Not Cancer Driver No 1 hippie, biogrid 92 23 5 5 0
INHBE INHBE P58166 Inhibin beta E chain chr12 Not Cancer Driver No 1 hippie, biogrid 52 85 12 12 0
ISLR ISLR O14498 Immunoglobulin superfamily containing leucine-rich repeat protein chr15 Not Cancer Driver No 1 hippie, biogrid 83 87 13 13 0
KLK2 KLK2 P20151 Kallikrein-2 chr19 Census Yes 1 hippie, biogrid 53 11 3 3 0
LDLR LDLR P01130 Low-density lipoprotein receptor chr19 Not Cancer Driver No 2 intact, hippie 119 63 3 3 104
LY86 LY86 O95711 Lymphocyte antigen 86 chr6 Not Cancer Driver No 1 hippie, biogrid 29 0 0 0 0
LYPD4 LYPD4 Q6UWN0 Ly6/PLAUR domain-containing protein 4 chr19 Not Cancer Driver No 1 hippie, biogrid 44 0 0 0 0
LYZL1 LYZL1 Q6UWQ5-2 Isoform 2 of Lysozyme-like protein 1 chr10 Not Cancer Driver No 1 hippie, biogrid 32 6 4 4 0
MMP2 MMP2 P08253 72 kDa type IV collagenase chr16 Not Cancer Driver No 1 hippie 123 29 6 6 2
MSTN MSTN O14793 Growth/differentiation factor 8 chr2 Not Cancer Driver No 1 hippie, biogrid 68 64 11 11 0
NCR3 NCR3 O14931 Natural cytotoxicity triggering receptor 3 chr6 Not Cancer Driver No 1 hippie, biogrid 26 31 2 2 0
NXF1_ENST00000294172 NXF1 Q9UBU9 Nuclear RNA export factor 1 chr11 Compendium Yes 1 hippie 100 163 32 32 0
NXPH3 NXPH3 O95157 Neurexophilin-3 chr17 Not Cancer Driver No 1 hippie, biogrid 39 82 14 14 0
PCSK9 PCSK9 Q8NBP7 Proprotein convertase subtilisin/kexin type 9 chr1 Not Cancer Driver No 2 intact, hippie 86 148 27 27 9
PDGFRA PDGFRA P16234 Platelet-derived growth factor receptor alpha chr4 Census, Compendium Yes 1 hippie, biogrid 290 173 45 45 2
PDIA4 PDIA4 P13667 Protein disulfide-isomerase A4 chr7 Not Cancer Driver No 1 hippie 81 147 22 22 0
PGRMC1 PGRMC1 O00264 Membrane-associated progesterone receptor component 1 chrX Not Cancer Driver No 1 hippie 30 74 16 16 0
PI15 PI15 O43692 Peptidase inhibitor 15 chr8 Not Cancer Driver No 1 hippie, biogrid 87 4 1 1 0
PRG2 PRG2 P13727 Bone marrow proteoglycan chr11 Not Cancer Driver No 1 hippie, biogrid 45 65 15 15 0
PRG3 PRG3 Q9Y2Y8 Proteoglycan 3 chr11 Not Cancer Driver No 1 hippie, biogrid 40 60 12 12 0
PSCA PSCA O43653 Prostate stem cell antigen chr8 Not Cancer Driver No 1 hippie, biogrid 9 0 0 0 0
PTCH1 PTCH1 Q13635 Protein patched homolog 1 chr9 Census, Compendium Yes 1 hippie, biogrid 243 382 67 67 18
RCN1 RCN1 Q15293 Reticulocalbin-1 chr11 Not Cancer Driver No 1 hippie 35 158 19 19 0
RHOT1_ENST00000333942 RHOT1 Q8IXI2 Mitochondrial Rho GTPase 1 chr17 Not Cancer Driver No 1 hippie 56 46 2 2 0
RPL28_ENST00000559463 RPL28 P46779 60S ribosomal protein L28 chr19 Not Cancer Driver No 1 hippie 29 115 24 24 0
SDF2L1 SDF2L1 Q9HCN8 Stromal cell-derived factor 2-like protein 1 chr22 Not Cancer Driver No 1 hippie, biogrid 16 130 9 9 0
SEC11C SEC11C Q9BY50 Signal peptidase complex catalytic subunit SEC11C chr18 Not Cancer Driver No 1 hippie, biogrid 24 3 0 0 0
SLC25A1 SLC25A1 P53007 Tricarboxylate transport protein, mitochondrial chr22 Not Cancer Driver No 1 hippie 22 34 2 2 17
SLC25A10_ENST00000350690 SLC25A10 Q9UBX3 Mitochondrial dicarboxylate carrier chr17 Not Cancer Driver No 1 hippie 33 0 0 0 0
SLC25A12 SLC25A12 O75746 Calcium-binding mitochondrial carrier protein Aralar1 chr2 Not Cancer Driver No 1 hippie 110 21 7 7 2
STUB1 STUB1 Q9UNE7 E3 ubiquitin-protein ligase CHIP chr16 Not Cancer Driver No 1 hippie 35 112 14 14 12
TCTN1_ENST00000551590 TCTN1 Q2MV58 Tectonic-1 chr12 Not Cancer Driver No 1 hippie, biogrid 63 47 6 6 0
TDGF1 TDGF1 P13385 Teratocarcinoma-derived growth factor 1 chr3 Not Cancer Driver No 1 hippie, biogrid 39 25 2 2 0
TMEM87A TMEM87A Q8NBN3 Transmembrane protein 87A chr15 Not Cancer Driver No 1 hippie, biogrid 60 71 10 10 0
TRAF2 TRAF2 Q12933 TNF receptor-associated factor 2 chr9 Not Cancer Driver No 1 hippie 63 4 1 1 0
TRIM25 TRIM25 Q14258 E3 ubiquitin/ISG15 ligase TRIM25 chr17 Not Cancer Driver No 1 hippie 59 225 20 20 0
TUBB6 TUBB6 Q9BUF5 Tubulin beta-6 chain chr18 Not Cancer Driver No 1 hippie 69 51 5 5 1
UGGT1 UGGT1 Q9NYU2 UDP-glucose:glycoprotein glucosyltransferase 1 chr2 Not Cancer Driver No 1 hippie 169 161 20 20 0