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OMA1 ,OMA1 ,Q96E52
  • Number of Interaction partner in intact: 74
  • Number of Interaction partner in biogrid: 53
  • Number of Interaction partner in hippie: 131
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ABCB8 ABCB8 Q9NUT2 Mitochondrial potassium channel ATP-binding subunit chr7 Not Cancer Driver No 1 hippie 117 55 5 5 0
ACAD9 ACAD9 Q9H845 Complex I assembly factor ACAD9, mitochondrial chr3 Not Cancer Driver No 1 intact, hippie 69 28 5 5 12
ADCK2 ADCK2 Q7Z695 Uncharacterized aarF domain-containing protein kinase 2 chr7 Not Cancer Driver No 1 intact, hippie 62 9 1 1 0
ADCY8 ADCY8 P40145 Adenylate cyclase type 8 chr8 Not Cancer Driver No 1 hippie, biogrid 419 215 38 38 0
ADCY9 ADCY9 O60503 Adenylate cyclase type 9 chr16 Not Cancer Driver No 1 hippie, biogrid 195 271 42 42 0
AFG3L2 AFG3L2 Q9Y4W6 AFG3-like protein 2 chr18 Not Cancer Driver No 1 intact, hippie 72 162 10 10 22
AIFM1 AIFM1 O95831 Apoptosis-inducing factor 1, mitochondrial chrX Not Cancer Driver No 3 intact, hippie, biogrid 88 166 22 22 11
AK2 AK2 P54819 Adenylate kinase 2, mitochondrial chr1 Not Cancer Driver No 1 intact, hippie 23 76 12 12 2
AMIGO3 AMIGO3 Q86WK7 Amphoterin-induced protein 3 chr3 Not Cancer Driver No 2 hippie, biogrid 69 60 7 7 0
APOO APOO Q9BUR5 MICOS complex subunit MIC26 chrX Not Cancer Driver No 2 hippie, biogrid 25 23 4 4 0
APOOL APOOL Q6UXV4 MICOS complex subunit MIC27 chrX Not Cancer Driver No 1 intact, hippie 31 91 8 8 0
ATAD3A ATAD3A Q9NVI7 ATPase family AAA domain-containing protein 3A chr1 Not Cancer Driver No 1 intact, hippie 66 269 24 24 2
ATAD3B ATAD3B Q5T9A4 ATPase family AAA domain-containing protein 3B chr1 Not Cancer Driver No 1 hippie 84 243 19 19 0
ATP11A ATP11A P98196 Phospholipid-transporting ATPase IH chr13 Not Cancer Driver No 1 hippie, biogrid 171 77 17 17 0
ATP1A1_ENST00000295598 ATP1A1 P05023 Sodium/potassium-transporting ATPase subunit alpha-1 chr1 Census Yes 1 hippie, biogrid 115 115 16 16 6
ATP1B1 ATP1B1 P05026 Sodium/potassium-transporting ATPase subunit beta-1 chr1 Not Cancer Driver No 1 hippie, biogrid 38 55 9 9 0
ATPAF1_ENST00000574428 ATPAF1 Q5TC12 ATP synthase mitochondrial F1 complex assembly factor 1 chr1 Not Cancer Driver No 1 intact, hippie 33 47 8 8 0
B4GALT5 B4GALT5 O43286 Beta-1,4-galactosyltransferase 5 chr20 Not Cancer Driver No 1 hippie, biogrid 53 20 1 1 0
BZW2_ENST00000258761 BZW2 Q9Y6E2 eIF5-mimic protein 1 chr7 Not Cancer Driver No 2 hippie, biogrid 41 58 8 8 0
C5AR1 C5AR1 P21730 C5a anaphylatoxin chemotactic receptor 1 chr19 Not Cancer Driver No 1 hippie, biogrid 71 0 0 0 0
CBR1 CBR1 P16152 Carbonyl reductase [NADPH] 1 chr21 Not Cancer Driver No 1 hippie 27 62 11 11 0
CCDC142_ENST00000393965 CCDC142 Q17RM4 Coiled-coil domain-containing protein 142 chr2 Not Cancer Driver No 1 hippie, biogrid 58 165 15 15 0
CCDC58 MIX23 Q4VC31 Protein MIX23 chr3 Not Cancer Driver No 1 intact 17 15 2 2 0
CHCHD3 CHCHD3 Q9NX63 MICOS complex subunit MIC19 chr7 Not Cancer Driver No 1 intact, hippie 26 143 16 16 0
CHCHD6 CHCHD6 Q9BRQ6 MICOS complex subunit MIC25 chr3 Not Cancer Driver No 1 intact, hippie 27 194 24 24 0
CKMT1B_ENST00000441322 CKMT1B P12532 Creatine kinase U-type, mitochondrial chr15 Not Cancer Driver No 1 hippie 25 77 1 1 0
CLPB CLPB Q9H078 Caseinolytic peptidase B protein homolog chr11 Not Cancer Driver No 1 intact, hippie 69 224 25 25 11
CNPPD1 CNPPD1 Q9BV87 Protein CNPPD1 chr2 Not Cancer Driver No 2 hippie, biogrid 49 12 1 1 0
COA3 COA3 Q9Y2R0 Cytochrome c oxidase assembly factor 3 homolog, mitochondrial chr17 Not Cancer Driver No 1 intact, hippie 4 57 3 3 0
COA7 COA7 Q96BR5 Cytochrome c oxidase assembly factor 7 chr1 Not Cancer Driver No 1 intact, hippie 25 39 7 7 2
COX15 COX15 Q7KZN9 Cytochrome c oxidase assembly protein COX15 homolog chr10 Not Cancer Driver No 1 intact, hippie 48 0 0 0 2
COX4I1 COX4I1 P13073 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial chr16 Not Cancer Driver No 2 intact, hippie 17 5 1 1 1
COX5A COX5A P20674 Cytochrome c oxidase subunit 5A, mitochondrial chr15 Not Cancer Driver No 1 hippie 20 14 5 5 1
COX5B COX5B P10606 Cytochrome c oxidase subunit 5B, mitochondrial chr2 Not Cancer Driver No 1 hippie 16 58 6 6 0
COX6C_ENST00000522940 COX6C P09669 Cytochrome c oxidase subunit 6C chr8 Census Yes 1 intact, hippie 14 0 0 0 0
CPOX CPOX P36551 Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial chr3 Not Cancer Driver No 1 intact, hippie 49 126 7 7 17
CYC1 CYC1 P08574 Cytochrome c1, heme protein, mitochondrial chr8 Not Cancer Driver No 1 intact, hippie 65 35 8 8 2
CYCS_ENST00000409409 CYCS P99999 Cytochrome c chr7 Not Cancer Driver No 1 intact, hippie 12 19 3 3 1
DNAH17 DNAH17 Q9UFH2 Dynein axonemal heavy chain 17 chr17 Not Cancer Driver No 1 hippie, biogrid 725 175 31 31 3
DNAJC11 DNAJC11 Q9NVH1 DnaJ homolog subfamily C member 11 chr1 Not Cancer Driver No 1 intact, hippie 66 123 14 14 0
ECSIT ECSIT Q9BQ95 Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial chr19 Not Cancer Driver No 1 hippie 58 146 29 29 0
EDEM1 EDEM1 Q92611 ER degradation-enhancing alpha-mannosidase-like protein 1 chr3 Not Cancer Driver No 1 hippie, biogrid 54 141 5 5 0
EDEM2 EDEM2 Q9BV94 ER degradation-enhancing alpha-mannosidase-like protein 2 chr20 Not Cancer Driver No 2 intact, hippie, biogrid 69 54 3 3 0
EMC1 EMC1 Q8N766 ER membrane protein complex subunit 1 chr1 Not Cancer Driver No 1 hippie 107 59 6 6 2
ENDOG ENDOG Q14249 Endonuclease G, mitochondrial chr9 Not Cancer Driver No 1 intact, hippie 11 61 1 1 0
ERP44 ERP44 Q9BS26 Endoplasmic reticulum resident protein 44 chr9 Not Cancer Driver No 1 intact, hippie 43 43 3 3 0
FAM136A FAM136A Q96C01 Protein FAM136A chr2 Not Cancer Driver No 1 intact, hippie 17 13 1 1 0
FAM162A FAM162A Q96A26 Protein FAM162A chr3 Not Cancer Driver No 1 intact, hippie 18 53 8 8 0
FAM8A1 FAM8A1 Q9UBU6 Protein FAM8A1 chr6 Not Cancer Driver No 2 intact, hippie, biogrid 34 196 14 14 0
FANCC FANCC Q00597 Fanconi anemia group C protein chr9 Census, Compendium Yes 1 hippie, biogrid 66 13 1 1 3
GCGR GCGR P47871 Glucagon receptor chr17 Not Cancer Driver No 1 hippie, biogrid 16 56 2 2 4
GPD2_ENST00000438166 GPD2 P43304 Glycerol-3-phosphate dehydrogenase, mitochondrial chr2 Not Cancer Driver No 1 intact, hippie 88 67 7 7 0
GXYLT1 GXYLT1 Q4G148 Glucoside xylosyltransferase 1 chr12 Not Cancer Driver No 2 intact, hippie, biogrid 58 7 0 0 0
HAX1 HAX1 O00165 HCLS1-associated protein X-1 chr1 Not Cancer Driver No 1 intact, hippie 44 219 32 32 2
HCCS HCCS P53701 Holocytochrome c-type synthase chrX Not Cancer Driver No 1 hippie 48 117 25 25 1
IARS2 IARS2 Q9NSE4 Isoleucine--tRNA ligase, mitochondrial chr1 Not Cancer Driver No 1 intact, hippie 149 145 22 22 0
IFNA8 IFNA8 P32881 Interferon alpha-8 chr9 Not Cancer Driver No 3 hippie, biogrid 43 0 0 0 0
IFNGR2_ENST00000290219 IFNGR2 P38484 Interferon gamma receptor 2 chr21 Not Cancer Driver No 1 hippie, biogrid 36 18 2 2 5
IMMP1L IMMP1L Q96LU5 Mitochondrial inner membrane protease subunit 1 chr11 Not Cancer Driver No 1 hippie 20 3 0 0 0
IMMP2L_ENST00000452895 IMMP2L Q96T52 Mitochondrial inner membrane protease subunit 2 chr7 Not Cancer Driver No 1 hippie 36 29 7 7 0
IMMT IMMT Q16891 MICOS complex subunit MIC60 chr2 Not Cancer Driver No 1 hippie 97 400 50 50 0
IRGC IRGC Q6NXR0 Interferon-inducible GTPase 5 chr19 Not Cancer Driver No 2 intact, hippie, biogrid 98 158 36 36 0
KCNK18 KCNK18 Q7Z418 Potassium channel subfamily K member 18 chr10 Not Cancer Driver No 1 hippie, biogrid 103 7 0 0 0
KLRC1 KLRC1 P26715 NKG2-A/NKG2-B type II integral membrane protein chr12 Not Cancer Driver No 1 hippie, biogrid 49 49 10 10 0
KRT81 KRT81 Q14533 Keratin, type II cuticular Hb1 chr12 Not Cancer Driver No 1 hippie, biogrid 52 18 4 4 3
KRT86 KRT86 O43790 Keratin, type II cuticular Hb6 chr12 Not Cancer Driver No 1 biogrid 58 27 5 5 8
KRTAP19-7 KRTAP19-7 Q3SYF9 Keratin-associated protein 19-7 chr21 Not Cancer Driver No 1 hippie, biogrid 20 0 0 0 0
KRTAP6-1 KRTAP6-1 Q3LI64 Keratin-associated protein 6-1 chr21 Not Cancer Driver No 1 hippie, biogrid 27 0 0 0 0
LACTB LACTB P83111 Serine beta-lactamase-like protein LACTB, mitochondrial chr15 Not Cancer Driver No 1 intact, hippie 44 121 3 3 0
LETM1 LETM1 O95202 Mitochondrial proton/calcium exchanger protein chr4 Not Cancer Driver No 1 hippie 77 286 28 28 0
MCM3_ENST00000229854 MCM3 P25205 DNA replication licensing factor MCM3 chr6 Not Cancer Driver No 1 intact, hippie 92 310 47 47 0
MICU1 MICU1 Q9BPX6 Calcium uptake protein 1, mitochondrial chr10 Not Cancer Driver No 1 intact, hippie 50 97 18 18 0
MICU2 MICU2 Q8IYU8 Calcium uptake protein 2, mitochondrial chr13 Not Cancer Driver No 1 intact, hippie 45 10 1 1 0
MTX1 MTX1 Q13505 Metaxin-1 chr1 Not Cancer Driver No 1 intact, hippie 25 221 7 7 0
MTX2 MTX2 O75431 Metaxin-2 chr2 Not Cancer Driver No 1 intact, hippie 33 0 0 0 0
NCR3LG1 NCR3LG1 Q68D85 Natural cytotoxicity triggering receptor 3 ligand 1 chr11 Not Cancer Driver No 2 intact, hippie, biogrid 8 70 3 3 0
NDUFA12 NDUFA12 Q9UI09 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 chr12 Not Cancer Driver No 1 intact, hippie 18 31 6 6 0
NDUFA8 NDUFA8 P51970 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 chr9 Not Cancer Driver No 1 intact, hippie 25 33 1 1 2
NDUFAF4 NDUFAF4 Q9P032 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 chr6 Not Cancer Driver No 1 intact, hippie 14 46 4 4 2
NDUFB10 NDUFB10 O96000 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 chr16 Not Cancer Driver No 1 intact, hippie 19 33 1 1 1
NDUFB11_ENST00000377811 NDUFB11 Q9NX14 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial chrX Not Cancer Driver No 1 intact, hippie 26 51 6 6 1
NDUFB5 NDUFB5 O43674 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial chr3 Not Cancer Driver No 1 intact, hippie 28 9 1 1 0
NDUFB9 NDUFB9 Q9Y6M9 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 chr8 Not Cancer Driver No 1 hippie 23 34 5 5 1
NDUFS1_ENST00000449699 NDUFS1 P28331 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial chr2 Not Cancer Driver No 1 intact, hippie 81 40 3 3 2
NDUFS2 NDUFS2 O75306 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial chr1 Not Cancer Driver No 1 intact, hippie 58 49 5 5 4
NDUFV2 NDUFV2 P19404 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial chr18 Not Cancer Driver No 1 hippie 40 69 15 15 0
NDUFV3_ENST00000340344 NDUFV3 P56181 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial chr21 Not Cancer Driver No 1 hippie 5 95 4 4 0
OCIAD1 OCIAD1 Q9NX40 OCIA domain-containing protein 1 chr4 Not Cancer Driver No 1 hippie 37 169 25 25 0
OCIAD2 OCIAD2 Q56VL3 OCIA domain-containing protein 2 chr4 Not Cancer Driver No 1 hippie 21 27 4 4 0
OPA1_ENST00000392438 OPA1 O60313 Dynamin-like 120 kDa protein, mitochondrial chr3 Not Cancer Driver No 1 hippie 114 131 17 17 60
OPRL1_ENST00000336866 OPRL1 P41146 Nociceptin receptor chr20 Not Cancer Driver No 1 hippie, biogrid 81 0 0 0 0
P2RX1 P2RX1 P51575 P2X purinoceptor 1 chr17 Not Cancer Driver No 2 hippie, biogrid 59 14 1 1 0
PARL PARL Q9H300 Presenilins-associated rhomboid-like protein, mitochondrial chr3 Not Cancer Driver No 1 intact, hippie 49 28 5 5 0
PBXIP1 PBXIP1 Q96AQ6 Pre-B-cell leukemia transcription factor-interacting protein 1 chr1 Not Cancer Driver No 1 hippie, biogrid 100 605 86 86 0
PLGRKT PLGRKT Q9HBL7 Plasminogen receptor (KT) chr9 Not Cancer Driver No 1 intact, hippie 17 0 0 0 0
RNF4 RNF4 P78317 E3 ubiquitin-protein ligase RNF4 chr4 Not Cancer Driver No 1 hippie 14 117 7 7 0
RNH1_ENST00000397604 RNH1 P13489 Ribonuclease inhibitor chr11 Not Cancer Driver No 1 intact, hippie 40 0 0 0 0
SAAL1 SAAL1 Q96ER3 Protein SAAL1 chr11 Not Cancer Driver No 1 hippie, biogrid 46 75 11 11 0
SAMM50 SAMM50 Q9Y512 Sorting and assembly machinery component 50 homolog chr22 Not Cancer Driver No 1 intact, hippie 51 34 1 1 0
SCN3B_ENST00000299333 SCN3B Q9NY72 Sodium channel subunit beta-3 chr11 Not Cancer Driver No 2 intact, hippie, biogrid 63 16 5 5 3
SCO1 SCO1 O75880 Protein SCO1 homolog, mitochondrial chr17 Not Cancer Driver No 1 intact, hippie 35 79 7 7 1
SFXN1 SFXN1 Q9H9B4 Sideroflexin-1 chr5 Not Cancer Driver No 2 intact, hippie, biogrid 31 29 1 1 0
SIDT2_ENST00000620360 SIDT2 Q8NBJ9 SID1 transmembrane family member 2 chr11 Not Cancer Driver No 1 hippie, biogrid 113 23 6 6 0
SIL1_ENST00000265195 SIL1 Q9H173 Nucleotide exchange factor SIL1 chr5 Not Cancer Driver No 2 intact, hippie, biogrid 39 125 12 12 0
SLC15A1 SLC15A1 P46059 Solute carrier family 15 member 1 chr13 Not Cancer Driver No 2 intact, hippie, biogrid 122 24 7 7 0
SLC25A12 SLC25A12 O75746 Calcium-binding mitochondrial carrier protein Aralar1 chr2 Not Cancer Driver No 1 intact, hippie 110 21 7 7 2
SLC25A24 SLC25A24 Q6NUK1 Calcium-binding mitochondrial carrier protein SCaMC-1 chr1 Not Cancer Driver No 1 intact, hippie 40 21 2 2 2
SLC25A25_ENST00000373064 SLC25A25 Q6KCM7 Calcium-binding mitochondrial carrier protein SCaMC-2 chr9 Not Cancer Driver No 1 intact 45 5 1 1 0
SLC25A51_ENST00000242275 SLC25A51 Q9H1U9 Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51 chr9 Not Cancer Driver No 1 hippie, biogrid 31 21 0 0 0
SLC26A4_ENST00000644269 SLC26A4 O43511 Pendrin chr7 Not Cancer Driver No 1 hippie, biogrid 129 10 0 0 73
SLC30A9 SLC30A9 Q6PML9 Zinc transporter 9 chr4 Not Cancer Driver No 1 intact, hippie 76 61 9 9 0
SLC39A4 SLC39A4 Q6P5W5 Zinc transporter ZIP4 chr8 Not Cancer Driver No 3 intact, hippie, biogrid 77 116 11 11 9
SLC4A8 SLC4A8 Q2Y0W8 Electroneutral sodium bicarbonate exchanger 1 chr12 Not Cancer Driver No 2 intact, hippie, biogrid 176 276 41 41 0
SLC5A4 SLC5A4 Q9NY91 Solute carrier family 5 member 4 chr22 Not Cancer Driver No 1 hippie, biogrid 103 48 6 6 0
SMIM12 SMIM12 Q96EX1 Small integral membrane protein 12 chr1 Not Cancer Driver No 1 intact, hippie 6 28 4 4 0
SYCE3 SYCE3 A1L190 Synaptonemal complex central element protein 3 chr22 Not Cancer Driver No 2 intact, hippie, biogrid 8 40 2 2 0
TBC1D25 TBC1D25 Q3MII6 TBC1 domain family member 25 chrX Not Cancer Driver No 1 intact, hippie, biogrid 114 256 37 37 0
TIMM13 TIMM13 Q9Y5L4 Mitochondrial import inner membrane translocase subunit Tim13 chr19 Not Cancer Driver No 1 intact, hippie 7 20 1 1 0
TIMM8A_ENST00000647359 TIMM8A O60220 Mitochondrial import inner membrane translocase subunit Tim8 A chrX Not Cancer Driver No 1 hippie 16 22 1 1 1
TIMMDC1 TIMMDC1 Q9NPL8 Complex I assembly factor TIMMDC1, mitochondrial chr3 Not Cancer Driver No 1 hippie 44 50 6 6 0
TMEM126B TMEM126B Q8IUX1 Complex I assembly factor TMEM126B, mitochondrial chr11 Not Cancer Driver No 1 intact, hippie 21 18 1 1 1
TMEM186 TMEM186 Q96B77 Transmembrane protein 186 chr16 Not Cancer Driver No 1 hippie 28 2 0 0 0
TMEM9_ENST00000485839 TMEM9 Q9P0T7 Proton-transporting V-type ATPase complex assembly regulator TMEM9 chr1 Not Cancer Driver No 1 hippie, biogrid 22 23 3 3 0
TOMM70 TOMM70 O94826 Mitochondrial import receptor subunit TOM70 chr3 Not Cancer Driver No 1 intact, hippie 59 140 8 8 0
TOR3A TOR3A Q9H497 Torsin-3A chr1 Not Cancer Driver No 3 intact, hippie, biogrid 50 15 0 0 0
TPP1 TPP1 O14773 Tripeptidyl-peptidase 1 chr11 Not Cancer Driver No 2 intact, hippie, biogrid 67 92 7 7 37
TTC19 TTC19 Q6DKK2 Tetratricopeptide repeat protein 19, mitochondrial chr17 Not Cancer Driver No 1 intact, hippie 34 76 3 3 0
TTYH1_ENST00000376530 TTYH1 Q9H313 Protein tweety homolog 1 chr19 Not Cancer Driver No 1 hippie, biogrid 56 21 3 3 0
TUBGCP3 TUBGCP3 Q96CW5 Gamma-tubulin complex component 3 chr13 Not Cancer Driver No 1 hippie, biogrid 109 156 16 16 0
UGGT1 UGGT1 Q9NYU2 UDP-glucose:glycoprotein glucosyltransferase 1 chr2 Not Cancer Driver No 1 intact, hippie 169 161 20 20 0
USP30 USP30 Q70CQ3 Ubiquitin carboxyl-terminal hydrolase 30 chr12 Not Cancer Driver No 1 intact, hippie 76 136 26 26 0
UST UST Q9Y2C2 Uronyl 2-sulfotransferase chr6 Not Cancer Driver No 1 hippie, biogrid 70 57 8 8 0
VAC14 VAC14 Q08AM6 Protein VAC14 homolog chr16 Not Cancer Driver No 1 hippie, biogrid 97 116 19 19 3
YME1L1 YME1L1 Q96TA2 ATP-dependent zinc metalloprotease YME1L1 chr10 Not Cancer Driver No 1 intact, hippie 112 136 14 14 1