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NVL ,NVL ,O15381
  • Uniprot Accession= O15381
  • Ensembl Transcript= ENST00000281701.10
  • Uniprot Name= NVL
  • Name= Nuclear valosin-containing protein-like
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 35
  • Number of Interaction partner in biogrid: 73
  • Number of Interaction partner in hippie: 136
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
ABT1 ABT1 Q9ULW3 Activator of basal transcription 1 chr6 Not Cancer Driver No 1 hippie, biogrid 56 157 30 30 0
ADARB1 ADARB1 P78563 Double-stranded RNA-specific editase 1 chr21 Not Cancer Driver No 1 hippie, biogrid 102 348 34 34 1
AKR7L AKR7L Q8NHP1 Aflatoxin B1 aldehyde reductase member 4 chr1 Not Cancer Driver No 1 hippie, biogrid 40 50 4 4 0
ANLN ANLN Q9NQW6 Anillin chr7 Not Cancer Driver No 1 hippie 144 767 104 104 2
ANOS1 ANOS1 P23352 Anosmin-1 chrX Not Cancer Driver No 1 hippie 124 195 44 44 14
APOBEC3C APOBEC3C Q9NRW3 DNA dC->dU-editing enzyme APOBEC-3C chr22 Not Cancer Driver No 1 hippie, biogrid 28 2 0 0 0
AR AR P10275 Androgen receptor chrX Census, Compendium Yes 1 hippie 196 443 88 88 169
ATXN1 ATXN1 P54253 Ataxin-1 chr6 Not Cancer Driver No 1 intact, hippie 193 604 168 168 0
BRD4 BRD4 O60885 Bromodomain-containing protein 4 chr19 Census, Compendium Yes 1 hippie 193 1182 172 172 0
CCDC137 CCDC137 Q6PK04 Coiled-coil domain-containing protein 137 chr17 Not Cancer Driver No 1 hippie, biogrid 25 284 25 25 0
CCDC140 CCDC140 Q96MF4 Coiled-coil domain-containing protein 140 chr2 Not Cancer Driver No 1 hippie, biogrid 36 163 36 36 0
CCNF CCNF P41002 Cyclin-F chr16 Not Cancer Driver No 1 hippie, biogrid 106 221 23 23 3
CDX1 CDX1 P47902 Homeobox protein CDX-1 chr5 Not Cancer Driver No 1 hippie, biogrid 21 241 13 13 0
CEP164 CEP164 Q9UPV0 Centrosomal protein of 164 kDa chr11 Not Cancer Driver No 1 intact, hippie 161 1198 124 124 2
CEP19 CEP19 Q96LK0 Centrosomal protein of 19 kDa chr3 Not Cancer Driver No 1 intact, hippie 30 71 11 11 0
CHMP4B CHMP4B Q9H444 Charged multivesicular body protein 4b chr20 Not Cancer Driver No 1 hippie 25 201 22 22 2
CHMP4C CHMP4C Q96CF2 Charged multivesicular body protein 4c chr8 Not Cancer Driver No 1 hippie 33 224 31 31 0
CIC CIC Q96RK0 Protein capicua homolog chr19 Census, Compendium Yes 1 hippie 276 1550 266 266 0
CIT_ENST00000261833 CIT O14578 Citron Rho-interacting kinase chr12 Not Cancer Driver No 1 hippie 284 1017 160 160 3
CLCN2 CLCN2 P51788 Chloride channel protein 2 chr3 Not Cancer Driver No 1 intact, hippie 124 224 38 38 8
CRMP1_ENST00000397890 CRMP1 Q14194 Dihydropyrimidinase-related protein 1 chr4 Not Cancer Driver No 1 intact, hippie, biogrid 122 96 15 15 0
CUL3 CUL3 Q13618 Cullin-3 chr2 Census, Compendium Yes 1 intact, hippie 123 167 23 23 3
CUL9 CUL9 Q8IWT3 Cullin-9 chr6 Not Cancer Driver No 1 hippie, biogrid 321 633 73 73 0
DCAF13_ENST00000612750 DCAF13 Q9NV06 DDB1- and CUL4-associated factor 13 chr8 Not Cancer Driver No 1 hippie 85 101 18 18 0
DCTN1 DCTN1 Q14203 Dynactin subunit 1 chr2 Census Yes 1 intact, hippie 172 817 111 111 11
DDRGK1 DDRGK1 Q96HY6 DDRGK domain-containing protein 1 chr20 Not Cancer Driver No 1 hippie 34 181 23 23 0
DDX21 DDX21 Q9NR30 Nucleolar RNA helicase 2 chr10 Not Cancer Driver No 1 hippie, biogrid 72 342 30 30 0
DDX23 DDX23 Q9BUQ8 Probable ATP-dependent RNA helicase DDX23 chr12 Not Cancer Driver No 1 hippie, biogrid 121 426 71 71 0
DGCR8 DGCR8 Q8WYQ5 Microprocessor complex subunit DGCR8 chr22 Census, Compendium Yes 2 intact, hippie, biogrid 102 466 57 57 0
DNAJC17 DNAJC17 Q9NVM6 DnaJ homolog subfamily C member 17 chr15 Not Cancer Driver No 1 hippie, biogrid 39 209 28 28 0
DNAJC9 DNAJC9 Q8WXX5 DnaJ homolog subfamily C member 9 chr10 Not Cancer Driver No 1 hippie, biogrid 28 126 15 15 0
DR1_ENST00000370267 DR1 Q01658 Protein Dr1 chr1 Not Cancer Driver No 1 hippie 21 84 12 12 0
ECT2 ECT2 Q9H8V3 Protein ECT2 chr3 Not Cancer Driver No 1 hippie 104 284 33 33 0
ESR2 ESR2 Q92731 Estrogen receptor beta chr14 Not Cancer Driver No 1 hippie 90 92 11 11 1
EXOSC10 EXOSC10 Q01780 Exosome component 10 chr1 Not Cancer Driver No 1 hippie 87 375 35 35 0
EXOSC2 EXOSC2 Q13868 Exosome complex component RRP4 chr9 Not Cancer Driver No 1 hippie, biogrid 21 47 6 6 2
FBXO7 FBXO7 Q9Y3I1 F-box only protein 7 chr22 Not Cancer Driver No 1 hippie 75 243 38 38 1
FGF8_ENST00000344255 FGF8 P55075 Fibroblast growth factor 8 chr10 Not Cancer Driver No 2 hippie, biogrid 30 79 9 9 6
GPATCH4_ENST00000368232 GPATCH4 A0A0A0MRK1 G patch domain-containing protein 4 chr1 Not Cancer Driver No 2 intact, hippie, biogrid 42 359 39 39 0
GTF2B GTF2B Q00403 Transcription initiation factor IIB chr1 Not Cancer Driver No 1 intact, hippie 33 80 6 6 0
GTF3C3 GTF3C3 Q9Y5Q9 General transcription factor 3C polypeptide 3 chr2 Not Cancer Driver No 1 intact, hippie 109 195 22 22 0
HNRNPU HNRNPU Q00839 Heterogeneous nuclear ribonucleoprotein U chr1 Not Cancer Driver No 1 intact, hippie 77 504 45 45 0
HSPB1 HSPB1 P04792 Heat shock protein beta-1 chr7 Not Cancer Driver No 1 intact, hippie 10 118 8 8 20
HTRA2 HTRA2 O43464 Serine protease HTRA2, mitochondrial chr2 Compendium Yes 1 hippie 44 127 9 9 2
IFI16_ENST00000295809 IFI16 Q16666 Gamma-interferon-inducible protein 16 chr1 Not Cancer Driver No 1 hippie, biogrid 155 419 90 90 0
ILF2 ILF2 Q12905 Interleukin enhancer-binding factor 2 chr1 Not Cancer Driver No 1 hippie, biogrid 36 92 9 9 0
ILF3_ENST00000590261 ILF3 Q12906 Interleukin enhancer-binding factor 3 chr19 Not Cancer Driver No 1 hippie, biogrid 103 674 82 82 0
KIF14 KIF14 Q15058 Kinesin-like protein KIF14 chr1 Not Cancer Driver No 1 hippie 222 774 102 102 2
KIF1B_ENST00000377086 KIF1B O60333 Kinesin-like protein KIF1B chr1 Not Cancer Driver No 1 intact, hippie 253 633 106 106 1
KIF20A KIF20A O95235 Kinesin-like protein KIF20A chr5 Not Cancer Driver No 1 hippie 79 340 40 40 1
KIF21A KIF21A Q7Z4S6 Kinesin-like protein KIF21A chr12 Not Cancer Driver No 1 hippie 255 937 149 149 11
KIF23 KIF23 Q02241 Kinesin-like protein KIF23 chr15 Not Cancer Driver No 1 hippie 102 559 62 62 0
LYAR_ENST00000452476 LYAR Q9NX58 Cell growth-regulating nucleolar protein chr4 Not Cancer Driver No 1 hippie, biogrid 50 249 31 31 0
MAGEB10_ENST00000614159 MAGEB10 Q96LZ2 Melanoma-associated antigen B10 chrX Not Cancer Driver No 1 hippie, biogrid 97 160 49 49 0
MAGEB2 MAGEB2 O15479 Melanoma-associated antigen B2 chrX Not Cancer Driver No 1 hippie, biogrid 98 126 35 35 0
MAK16 MAK16 Q9BXY0 Protein MAK16 homolog chr8 Not Cancer Driver No 2 intact, hippie, biogrid 41 130 19 19 0
MECP2_ENST00000303391 MECP2 P51608 Methyl-CpG-binding protein 2 chrX Not Cancer Driver No 2 intact, hippie, biogrid 75 483 74 74 46
MKI67 MKI67 P46013 Proliferation marker protein Ki-67 chr10 Not Cancer Driver No 1 intact, hippie, biogrid 540 3169 529 529 0
MNDA MNDA P41218 Myeloid cell nuclear differentiation antigen chr1 Not Cancer Driver No 1 intact, hippie, biogrid 180 172 76 76 0
MOV10_ENST00000357443 MOV10 Q9HCE1 Helicase MOV-10 chr1 Not Cancer Driver No 1 hippie 110 101 8 8 0
MPHOSPH6 MPHOSPH6 Q99547 M-phase phosphoprotein 6 chr16 Not Cancer Driver No 1 hippie, biogrid 19 68 8 8 0
MYC_ENST00000377970 MYC P01106 Myc proto-oncogene protein chr8 Census, Compendium Yes 1 hippie 80 299 46 46 0
NDUFV2 NDUFV2 P19404 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial chr18 Not Cancer Driver No 1 hippie 40 69 15 15 0
NF2 NF2 P35240 Merlin chr22 Census, Compendium Yes 1 hippie 69 252 26 26 16
NFX1 NFX1 Q12986 Transcriptional repressor NF-X1 chr9 Not Cancer Driver No 1 hippie 121 491 46 46 0
NIFK NIFK Q9BYG3 MKI67 FHA domain-interacting nucleolar phosphoprotein chr2 Not Cancer Driver No 1 hippie, biogrid 32 148 15 15 0
NOP2_ENST00000322166 NOP2 P46087 Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase chr12 Not Cancer Driver No 1 hippie, biogrid 116 510 72 72 0
NOS3 NOS3 P29474 Nitric oxide synthase, endothelial chr7 Not Cancer Driver No 1 hippie 168 347 38 38 0
NPM1 NPM1 P06748 Nucleophosmin chr5 Census, Compendium Yes 4 intact, hippie, biogrid 29 249 22 22 0
NPM3 NPM3 O75607 Nucleoplasmin-3 chr10 Not Cancer Driver No 1 hippie, biogrid 23 78 11 11 0
NUPR1_ENST00000324873 NUPR1 O60356 Nuclear protein 1 chr16 Not Cancer Driver No 1 hippie 10 82 10 10 0
OSGEP OSGEP Q9NPF4 tRNA N6-adenosine threonylcarbamoyltransferase chr14 Not Cancer Driver No 1 hippie 46 32 4 4 14
PARP1 PARP1 P09874 Poly [ADP-ribose] polymerase 1 chr1 Not Cancer Driver No 1 hippie, biogrid 119 320 34 34 0
PES1 PES1 O00541 Pescadillo homolog chr22 Not Cancer Driver No 2 intact, hippie, biogrid 78 248 33 33 0
PLEKHA4 PLEKHA4 Q9H4M7 Pleckstrin homology domain-containing family A member 4 chr19 Not Cancer Driver No 1 hippie 136 687 128 128 0
PLEKHO1 PLEKHO1 Q53GL0 Pleckstrin homology domain-containing family O member 1 chr1 Not Cancer Driver No 2 hippie, biogrid 55 341 46 46 0
PMP22_ENST00000612492 PMP22 Q01453 Peripheral myelin protein 22 chr17 Not Cancer Driver No 1 intact 20 0 0 0 37
PNMA8A PNMA8A Q86V59 Paraneoplastic antigen-like protein 8A chr19 Not Cancer Driver No 1 hippie 82 290 55 55 0
PPAN PPAN Q9NQ55 Suppressor of SWI4 1 homolog chr19 Not Cancer Driver No 2 hippie, biogrid 65 257 42 42 0
PRC1 PRC1 O43663 Protein regulator of cytokinesis 1 chr15 Not Cancer Driver No 1 hippie 63 235 26 26 0
PRKRA PRKRA O75569 Interferon-inducible double-stranded RNA-dependent protein kinase activator A chr2 Not Cancer Driver No 1 hippie, biogrid 41 104 12 12 1
PRPH PRPH P41219 Peripherin chr12 Not Cancer Driver No 1 intact, hippie 37 239 20 20 0
PRPS1 PRPS1 P60891 Ribose-phosphate pyrophosphokinase 1 chrX Not Cancer Driver No 1 hippie 50 0 0 0 14
PRR11_ENST00000614081 PRR11 Q96HE9 Proline-rich protein 11 chr17 Not Cancer Driver No 3 intact, hippie, biogrid 44 220 21 21 0
PURG PURG Q9UJV8 Purine-rich element-binding protein gamma chr8 Not Cancer Driver No 1 hippie, biogrid 69 174 29 29 0
PYHIN1 PYHIN1 Q6K0P9 Pyrin and HIN domain-containing protein 1 chr1 Not Cancer Driver No 1 hippie 174 291 99 99 0
RBM34 RBM34 P42696 RNA-binding protein 34 chr1 Not Cancer Driver No 2 intact, hippie, biogrid 50 267 34 34 0
RBM4_ENST00000310092 RBM4 Q9BWF3 RNA-binding protein 4 chr11 Not Cancer Driver No 2 intact, hippie, biogrid 40 129 12 12 0
RHOA RHOA P61586 Transforming protein RhoA chr3 Census, Compendium Yes 1 hippie 99 46 13 13 2
RNF11 RNF11 Q9Y3C5 RING finger protein 11 chr1 Not Cancer Driver No 1 hippie 17 76 7 7 0
RNF4 RNF4 P78317 E3 ubiquitin-protein ligase RNF4 chr4 Not Cancer Driver No 1 hippie 14 117 7 7 0
RPL10_ENST00000369817 RPL10 P27635 60S ribosomal protein L10 chrX Census, Compendium Yes 1 intact, hippie 46 9 3 3 4
RPL11 RPL11 P62913 60S ribosomal protein L11 chr1 Not Cancer Driver No 1 hippie, biogrid 27 12 1 1 1
RPL13A RPL13A P40429 60S ribosomal protein L13a chr19 Not Cancer Driver No 1 hippie, biogrid 27 33 2 2 0
RPL14_ENST00000396203 RPL14 P50914 60S ribosomal protein L14 chr3 Not Cancer Driver No 1 hippie, biogrid 21 129 13 13 0
RPL15_ENST00000413699 RPL15 P61313 60S ribosomal protein L15 chr3 Not Cancer Driver No 1 hippie, biogrid 18 84 9 9 0
RPL17_ENST00000579248 RPL17 P18621 60S ribosomal protein L17 chr18 Not Cancer Driver No 1 hippie, biogrid 26 97 14 14 0
RPL18 RPL18 Q07020 60S ribosomal protein L18 chr19 Not Cancer Driver No 1 hippie, biogrid 16 98 6 6 0
RPL22 RPL22 P35268 60S ribosomal protein L22 chr1 Census, Compendium Yes 1 hippie, biogrid 26 15 1 1 0
RPL23A RPL23A P62750 60S ribosomal protein L23a chr17 Not Cancer Driver No 1 hippie, biogrid 21 70 13 13 0
RPL26L1 RPL26L1 Q9UNX3 60S ribosomal protein L26-like 1 chr5 Not Cancer Driver No 1 hippie, biogrid 21 107 11 11 0
RPL28_ENST00000559463 RPL28 P46779 60S ribosomal protein L28 chr19 Not Cancer Driver No 1 hippie, biogrid 29 115 24 24 0
RPL3 RPL3 P39023 60S ribosomal protein L3 chr22 Not Cancer Driver No 1 hippie, biogrid 34 79 3 3 0
RPL31_ENST00000264258 RPL31 P62899 60S ribosomal protein L31 chr2 Not Cancer Driver No 1 hippie, biogrid 19 69 14 14 0
RPL36_ENST00000347512 RPL36 Q9Y3U8 60S ribosomal protein L36 chr19 Not Cancer Driver No 1 hippie, biogrid 7 66 4 4 0
RPL4 RPL4 P36578 60S ribosomal protein L4 chr15 Not Cancer Driver No 1 hippie, biogrid 49 222 31 31 0
RPL5_ENST00000370321 RPL5 P46777 60S ribosomal protein L5 chr1 Census Yes 1 hippie 57 96 17 17 2
RPL7A RPL7A P62424 60S ribosomal protein L7a chr9 Not Cancer Driver No 1 hippie, biogrid 27 100 5 5 0
RPLP0_ENST00000228306 RPLP0 P05388 60S acidic ribosomal protein P0 chr12 Not Cancer Driver No 1 hippie, biogrid 44 36 4 4 0
RPS14_ENST00000521466 RPS14 P62263 40S ribosomal protein S14 chr5 Not Cancer Driver No 1 hippie, biogrid 14 96 13 13 0
RPS24_ENST00000613865 RPS24 P62847 40S ribosomal protein S24 chr10 Not Cancer Driver No 1 hippie, biogrid 13 88 10 10 0
RPS6 RPS6 P62753 40S ribosomal protein S6 chr9 Not Cancer Driver No 3 intact, hippie, biogrid 38 150 25 25 0
RRP8 RRP8 O43159 Ribosomal RNA-processing protein 8 chr11 Not Cancer Driver No 2 intact, hippie, biogrid 66 270 44 44 0
SIRT6 SIRT6 Q8N6T7 NAD-dependent protein deacylase sirtuin-6 chr19 Not Cancer Driver No 1 hippie 33 164 12 12 0
SIRT7 SIRT7 Q9NRC8 NAD-dependent protein deacetylase sirtuin-7 chr17 Not Cancer Driver No 1 hippie 48 163 15 15 0
SNCA_ENST00000506244 SNCA P37840 Alpha-synuclein chr4 Not Cancer Driver No 1 hippie 21 107 13 13 5
SNURF SNURF Q9Y675 SNRPN upstream reading frame protein chr15 Not Cancer Driver No 1 intact 19 67 19 19 0
SRP14 SRP14 P37108 Signal recognition particle 14 kDa protein chr15 Not Cancer Driver No 1 hippie, biogrid 10 74 8 8 0
SRPK3 SRPK3 Q9UPE1 SRSF protein kinase 3 chrX Not Cancer Driver No 1 hippie, biogrid 63 217 30 30 0
SRSF6 SRSF6 Q13247 Serine/arginine-rich splicing factor 6 chr20 Not Cancer Driver No 1 hippie, biogrid 69 259 49 49 0
STAU1 STAU1 O95793 Double-stranded RNA-binding protein Staufen homolog 1 chr20 Not Cancer Driver No 1 hippie, biogrid 77 456 63 63 0
SUMO2 SUMO2 P61956 Small ubiquitin-related modifier 2 chr17 Not Cancer Driver No 1 hippie 9 69 6 6 0
TARDBP TARDBP Q13148 TAR DNA-binding protein 43 chr1 Not Cancer Driver No 1 intact, hippie 51 202 15 15 27
TTF2 TTF2 Q9UNY4 Transcription termination factor 2 chr1 Not Cancer Driver No 1 intact, hippie 118 550 50 50 0
UBA1 UBA1 P22314 Ubiquitin-like modifier-activating enzyme 1 chrX Not Cancer Driver No 1 hippie 117 165 22 22 6
UBE2I UBE2I P63279 SUMO-conjugating enzyme UBC9 chr16 Not Cancer Driver No 1 intact, hippie 16 16 3 3 0
UCHL1 UCHL1 P09936 Ubiquitin carboxyl-terminal hydrolase isozyme L1 chr4 Not Cancer Driver No 1 hippie 33 34 7 7 4
UFL1 UFL1 O94874 E3 UFM1-protein ligase 1 chr6 Not Cancer Driver No 1 hippie 109 141 24 24 0
VRK1 VRK1 Q99986 Serine/threonine-protein kinase VRK1 chr14 Not Cancer Driver No 1 hippie 52 80 9 9 0
WDR46 WDR46 O15213 WD repeat-containing protein 46 chr6 Not Cancer Driver No 1 hippie, biogrid 61 297 23 23 0
WFS1_ENST00000503569 WFS1 O76024 Wolframin chr4 Not Cancer Driver No 1 intact, hippie 105 203 10 10 39
XRCC6 XRCC6 P12956 X-ray repair cross-complementing protein 6 chr22 Not Cancer Driver No 1 hippie 66 140 12 12 0
ZBTB47 ZBTB47 Q9UFB7 Zinc finger and BTB domain-containing protein 47 chr3 Not Cancer Driver No 1 hippie, biogrid 52 402 18 18 0
ZNF330 ZNF330 Q9Y3S2 Zinc finger protein 330 chr4 Not Cancer Driver No 1 hippie, biogrid 44 127 19 19 0
ZNF467 ZNF467 Q7Z7K2 Zinc finger protein 467 chr7 Not Cancer Driver No 1 hippie, biogrid 75 345 37 37 0
ZNF48 ZNF48 Q96MX3 Zinc finger protein 48 chr16 Not Cancer Driver No 1 hippie, biogrid 87 516 78 78 0
ZNF512 ZNF512 Q96ME7 Zinc finger protein 512 chr2 Not Cancer Driver No 2 intact, hippie, biogrid 76 280 42 42 0
ZNF71 ZNF71 Q9NQZ8 Endothelial zinc finger protein induced by tumor necrosis factor alpha chr19 Not Cancer Driver No 2 intact, hippie, biogrid 116 179 40 40 0