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NRDC_ENST00000352171 ,NRDC ,O43847
  • Uniprot Accession= O43847
  • Ensembl Transcript= ENST00000352171.11
  • Uniprot Name= NRDC
  • Name= Nardilysin
  • Chromosome= chr1
  • Driver status= Not Cancer Driver
  • Number of Interaction partner in intact: 31
  • Number of Interaction partner in biogrid: 0
  • Number of Interaction partner in hippie: 113
Identifier UniProt Gene UniProt Accession UniProt Name Chromosome Cancer Database Cancer Driver Number of independent pubication Interaction Database Number of missense mutations Number of disordered residues Number of mutations in disordered residues Number of mutations in disordered residues Number of omim mutations
AAR2_ENST00000320849 AAR2 Q9Y312 Protein AAR2 homolog chr20 Not Cancer Driver No 1 hippie 56 28 6 6 0
ACP6 ACP6 Q9NPH0 Lysophosphatidic acid phosphatase type 6 chr1 Not Cancer Driver No 1 hippie 53 40 5 5 0
ADCK2 ADCK2 Q7Z695 Uncharacterized aarF domain-containing protein kinase 2 chr7 Not Cancer Driver No 1 hippie 62 9 1 1 0
ANKEF1 ANKEF1 Q9NU02 Ankyrin repeat and EF-hand domain-containing protein 1 chr20 Not Cancer Driver No 1 hippie 118 128 18 18 0
APOOL APOOL Q6UXV4 MICOS complex subunit MIC27 chrX Not Cancer Driver No 1 hippie 31 91 8 8 0
ATM_ENST00000452508 ATM Q13315 Serine-protein kinase ATM chr11 Census, Compendium Yes 1 intact, hippie 469 225 39 39 41
ATP5F1A_ENST00000282050 ATP5F1A P25705 ATP synthase subunit alpha, mitochondrial chr18 Not Cancer Driver No 1 intact, hippie 66 23 5 5 2
AURKAIP1_ENST00000321751 AURKAIP1 Q9NWT8 Aurora kinase A-interacting protein chr1 Not Cancer Driver No 1 hippie 18 104 8 8 0
BAIAP2 BAIAP2 Q9UQB8 Brain-specific angiogenesis inhibitor 1-associated protein 2 chr17 Not Cancer Driver No 1 hippie 85 330 52 52 0
BATF3 BATF3 Q9NR55 Basic leucine zipper transcriptional factor ATF-like 3 chr1 Not Cancer Driver No 1 intact, hippie 18 127 18 18 0
BOLA1_ENST00000369150 BOLA1 Q9Y3E2 BolA-like protein 1 chr1 Not Cancer Driver No 1 hippie 27 71 11 11 0
BOLA3 BOLA3 Q53S33 BolA-like protein 3 chr2 Not Cancer Driver No 1 hippie 14 27 1 1 2
BRD1_ENST00000216267 BRD1 O95696 Bromodomain-containing protein 1 chr22 Not Cancer Driver No 1 hippie 171 425 68 68 0
BTRC BTRC Q9Y297 F-box/WD repeat-containing protein 1A chr10 Not Cancer Driver No 1 intact, hippie 80 45 4 4 0
CALCA_ENST00000361010 CALCA P06881 Calcitonin gene-related peptide 1 chr11 Not Cancer Driver No 1 hippie 25 44 11 11 0
CALCOCO2_ENST00000258947 CALCOCO2 Q13137 Calcium-binding and coiled-coil domain-containing protein 2 chr17 Not Cancer Driver No 1 hippie 42 212 19 19 0
CCDC140 CCDC140 Q96MF4 Coiled-coil domain-containing protein 140 chr2 Not Cancer Driver No 1 hippie 36 163 36 36 0
CDRT15 CDRT15 Q96T59 CMT1A duplicated region transcript 15 protein chr17 Not Cancer Driver No 1 intact, hippie 26 97 9 9 0
CHCHD1 CHCHD1 Q96BP2 Coiled-coil-helix-coiled-coil-helix domain-containing protein 1 chr10 Not Cancer Driver No 1 hippie 11 67 8 8 0
CHCHD2 CHCHD2 Q9Y6H1 Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 chr7 Not Cancer Driver No 1 intact, hippie 24 114 21 21 1
CLK3 CLK3 P49761 Dual specificity protein kinase CLK3 chr15 Not Cancer Driver No 1 intact, hippie 67 295 27 27 0
COBLL1_ENST00000375458 COBLL1 Q53SF7 Cordon-bleu protein-like 1 chr2 Not Cancer Driver No 1 hippie 165 951 150 150 0
COPS5 COPS5 Q92905 COP9 signalosome complex subunit 5 chr8 Not Cancer Driver No 1 hippie 36 32 7 7 0
COQ10A COQ10A Q96MF6 Coenzyme Q-binding protein COQ10 homolog A, mitochondrial chr12 Not Cancer Driver No 1 hippie 27 28 0 0 0
COQ6 COQ6 Q9Y2Z9 Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial chr14 Not Cancer Driver No 1 intact, hippie 58 20 2 2 2
COQ7_ENST00000568985 COQ7 Q99807 5-demethoxyubiquinone hydroxylase, mitochondrial chr16 Not Cancer Driver No 1 intact, hippie 27 5 1 1 1
COQ9 COQ9 O75208 Ubiquinone biosynthesis protein COQ9, mitochondrial chr16 Not Cancer Driver No 1 hippie 43 111 13 13 0
DEF8 DEF8 Q6ZN54 Differentially expressed in FDCP 8 homolog chr16 Not Cancer Driver No 1 intact, hippie 58 123 23 23 0
DHRS4 DHRS4 Q9BTZ2 Dehydrogenase/reductase SDR family member 4 chr14 Not Cancer Driver No 1 hippie 30 38 4 4 0
DNAJC7 DNAJC7 Q99615 DnaJ homolog subfamily C member 7 chr17 Not Cancer Driver No 1 hippie 41 102 9 9 0
DUSP5 DUSP5 Q16690 Dual specificity protein phosphatase 5 chr10 Not Cancer Driver No 1 hippie 58 36 4 4 0
EGLN3 EGLN3 Q9H6Z9 Prolyl hydroxylase EGLN3 chr14 Not Cancer Driver No 1 hippie 33 13 0 0 0
ELAC2 ELAC2 Q9BQ52 Zinc phosphodiesterase ELAC protein 2 chr17 Not Cancer Driver No 1 hippie 86 208 30 30 10
EP300 EP300 Q09472 Histone acetyltransferase p300 chr22 Census, Compendium Yes 1 hippie 334 1790 196 196 1
ERMAP_ENST00000372514 ERMAP Q96PL5 Erythroid membrane-associated protein chr1 Not Cancer Driver No 1 hippie 55 48 5 5 0
ERP44 ERP44 Q9BS26 Endoplasmic reticulum resident protein 44 chr9 Not Cancer Driver No 1 intact, hippie 43 43 3 3 0
FBXW11 FBXW11 Q9UKB1 F-box/WD repeat-containing protein 11 chr5 Not Cancer Driver No 1 hippie 75 20 3 3 7
FMC1 FMC1 Q96HJ9 Protein FMC1 homolog chr7 Not Cancer Driver No 1 intact, hippie 9 30 1 1 0
FMR1NB FMR1NB Q8N0W7 Fragile X mental retardation 1 neighbor protein chrX Not Cancer Driver No 2 intact, hippie 72 90 31 31 0
HBEGF HBEGF Q99075 Proheparin-binding EGF-like growth factor chr5 Not Cancer Driver No 1 hippie 16 63 3 3 0
HDAC3 HDAC3 O15379 Histone deacetylase 3 chr5 Not Cancer Driver No 1 hippie 65 61 8 8 0
HSPB1 HSPB1 P04792 Heat shock protein beta-1 chr7 Not Cancer Driver No 1 hippie 10 118 8 8 20
HSPD1 HSPD1 P10809 60 kDa heat shock protein, mitochondrial chr2 Not Cancer Driver No 1 intact, hippie 61 82 6 6 2
IMMP2L_ENST00000452895 IMMP2L Q96T52 Mitochondrial inner membrane protease subunit 2 chr7 Not Cancer Driver No 1 hippie 36 29 7 7 0
IQGAP1 IQGAP1 P46940 Ras GTPase-activating-like protein IQGAP1 chr15 Not Cancer Driver No 1 hippie 183 351 35 35 0
JUN JUN P05412 Transcription factor Jun chr1 Census Yes 1 hippie 35 281 25 25 0
KIF7 KIF7 Q2M1P5 Kinesin-like protein KIF7 chr15 Not Cancer Driver No 1 intact, hippie 150 844 104 104 5
KLRK1 KLRK1 P26718 NKG2-D type II integral membrane protein chr12 Not Cancer Driver No 1 hippie 38 0 0 0 0
KPNA3 KPNA3 O00505 Importin subunit alpha-4 chr13 Not Cancer Driver No 1 hippie 65 108 11 11 0
LGALS3BP LGALS3BP Q08380 Galectin-3-binding protein chr17 Not Cancer Driver No 1 intact, hippie 62 9 0 0 0
LMO1 LMO1 P25800 Rhombotin-1 chr11 Census Yes 1 hippie 23 0 0 0 0
LPIN2 LPIN2 Q92539 Phosphatidate phosphatase LPIN2 chr18 Not Cancer Driver No 1 hippie 113 455 56 56 1
LRRK2 LRRK2 Q5S007 Leucine-rich repeat serine/threonine-protein kinase 2 chr12 Not Cancer Driver No 1 intact, hippie 519 90 17 17 23
LUC7L LUC7L Q9NQ29 Putative RNA-binding protein Luc7-like 1 chr16 Not Cancer Driver No 2 intact, hippie 50 254 41 41 0
LYRM4_ENST00000330636 LYRM4 Q9HD34 LYR motif-containing protein 4 chr6 Not Cancer Driver No 1 hippie 14 11 1 1 1
MAD1L1_ENST00000399654 MAD1L1 Q9Y6D9 Mitotic spindle assembly checkpoint protein MAD1 chr7 Not Cancer Driver No 1 hippie 117 526 77 77 0
METTL25 METTL25 Q8N6Q8 Probable methyltransferase-like protein 25 chr12 Not Cancer Driver No 1 intact, hippie 65 149 16 16 0
MOB1A MOB1A Q9H8S9 MOB kinase activator 1A chr2 Not Cancer Driver No 1 hippie 16 10 2 2 0
MOB2_ENST00000614710 MOB2 Q70IA6 MOB kinase activator 2 chr11 Not Cancer Driver No 1 hippie 22 46 0 0 0
MOV10_ENST00000357443 MOV10 Q9HCE1 Helicase MOV-10 chr1 Not Cancer Driver No 1 hippie 110 101 8 8 0
MSH2 MSH2 P43246 DNA mismatch repair protein Msh2 chr2 Census Yes 1 hippie 92 37 4 4 70
MYC_ENST00000377970 MYC P01106 Myc proto-oncogene protein chr8 Census, Compendium Yes 1 hippie 80 299 46 46 0
NCOR1 NCOR1 O75376 Nuclear receptor corepressor 1 chr17 Census, Compendium Yes 1 hippie 352 2347 340 340 0
NCOR2 NCOR2 Q9Y618 Nuclear receptor corepressor 2 chr12 Census, Compendium Yes 1 hippie 373 2355 356 356 0
NDUFA4 NDUFA4 O00483 Cytochrome c oxidase subunit NDUFA4 chr7 Not Cancer Driver No 1 hippie 14 4 0 0 0
NDUFS3 NDUFS3 O75489 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial chr11 Not Cancer Driver No 1 intact, hippie 34 26 3 3 2
NLGN3 NLGN3 Q9NZ94 Neuroligin-3 chrX Not Cancer Driver No 1 intact, hippie 158 257 54 54 2
NME4 NME4 O00746 Nucleoside diphosphate kinase, mitochondrial chr16 Not Cancer Driver No 1 hippie 13 41 4 4 0
NRDC_ENST00000352171 NRDC O43847 Nardilysin chr1 Not Cancer Driver No 1 hippie 162 253 34 34 0
NSUN2 NSUN2 Q08J23 RNA cytosine C(5)-methyltransferase NSUN2 chr5 Not Cancer Driver No 1 hippie 112 221 21 21 1
NTRK1 NTRK1 P04629 High affinity nerve growth factor receptor chr1 Census, Compendium Yes 1 hippie 168 57 8 8 25
NXF1_ENST00000294172 NXF1 Q9UBU9 Nuclear RNA export factor 1 chr11 Compendium Yes 1 hippie 100 163 32 32 0
OCIAD1 OCIAD1 Q9NX40 OCIA domain-containing protein 1 chr4 Not Cancer Driver No 1 hippie 37 169 25 25 0
OPA3_ENST00000263275 OPA3 Q9H6K4 Optic atrophy 3 protein chr19 Not Cancer Driver No 1 intact, hippie 18 44 7 7 2
OXCT1 OXCT1 P55809 Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial chr5 Not Cancer Driver No 1 hippie 80 39 5 5 11
P3H1_ENST00000296388 P3H1 Q32P28 Prolyl 3-hydroxylase 1 chr1 Not Cancer Driver No 1 hippie 91 177 18 18 0
PCDHB15 PCDHB15 Q9Y5E8 Protocadherin beta-15 chr5 Not Cancer Driver No 1 intact, hippie 210 202 54 54 0
PDGFRA PDGFRA P16234 Platelet-derived growth factor receptor alpha chr4 Census, Compendium Yes 1 intact, hippie 290 173 45 45 2
PDIA6_ENST00000272227 PDIA6 Q15084 Protein disulfide-isomerase A6 chr2 Not Cancer Driver No 1 hippie 55 82 11 11 0
PDK1_ENST00000282077 PDK1 Q15118 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial chr2 Not Cancer Driver No 1 intact, hippie 52 50 10 10 0
PDYN PDYN P01213 Proenkephalin-B chr20 Not Cancer Driver No 1 hippie 124 111 61 61 8
PFDN1 PFDN1 O60925 Prefoldin subunit 1 chr5 Not Cancer Driver No 1 hippie 8 42 4 4 0
PFDN5 PFDN5 Q99471 Prefoldin subunit 5 chr12 Not Cancer Driver No 1 hippie 18 3 0 0 0
PIH1D1 PIH1D1 Q9NWS0 PIH1 domain-containing protein 1 chr19 Not Cancer Driver No 1 hippie 30 157 13 13 0
PNKP PNKP Q96T60 Bifunctional polynucleotide phosphatase/kinase chr19 Not Cancer Driver No 1 hippie 53 177 23 23 4
POMC POMC P01189 Pro-opiomelanocortin chr2 Not Cancer Driver No 1 hippie 50 198 38 38 0
PPP1R12A_ENST00000261207 PPP1R12A O14974 Protein phosphatase 1 regulatory subunit 12A chr12 Not Cancer Driver No 1 hippie 107 821 89 89 0
PPP2CA PPP2CA P67775 Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform chr5 Not Cancer Driver No 1 hippie 41 12 1 1 8
PPP2R2A_ENST00000380737 PPP2R2A P63151 Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform chr8 Not Cancer Driver No 1 hippie 60 68 10 10 0
PPP3CA PPP3CA Q08209 Protein phosphatase 3 catalytic subunit alpha chr4 Compendium Yes 1 hippie 85 140 27 27 7
PRM2_ENST00000241808 PRM2 P04554 Protamine-2 chr16 Not Cancer Driver No 1 hippie 23 102 23 23 0
PUS1 PUS1 Q9Y606 Pseudouridylate synthase 1 homolog chr12 Not Cancer Driver No 1 hippie 48 157 18 18 1
RCC1L RCC1L Q96I51 RCC1-like G exchanging factor-like protein chr7 Not Cancer Driver No 1 hippie 19 87 7 7 0
RECQL4 RECQL4 O94761 ATP-dependent DNA helicase Q4 chr8 Census, Compendium Yes 1 hippie 138 608 71 71 1
RPL10_ENST00000369817 RPL10 P27635 60S ribosomal protein L10 chrX Census, Compendium Yes 1 hippie 46 9 3 3 4
RPL36AL RPL36AL Q969Q0 60S ribosomal protein L36a-like chr14 Not Cancer Driver No 1 hippie 9 64 7 7 0
RPS25 RPS25 P62851 40S ribosomal protein S25 chr11 Not Cancer Driver No 1 hippie 16 60 8 8 0
SEPT1 SEPTIN1 J3KNL2 Septin chr16 Not Cancer Driver No 1 intact 44 102 10 10 0
SETSIP SETSIP P0DME0 Protein SETSIP chr1 Not Cancer Driver No 1 hippie 6 225 4 4 0
SLX4 SLX4 Q8IY92 Structure-specific endonuclease subunit SLX4 chr16 Not Cancer Driver No 1 intact, hippie 271 1573 232 232 0
STAU1 STAU1 O95793 Double-stranded RNA-binding protein Staufen homolog 1 chr20 Not Cancer Driver No 1 hippie 77 456 63 63 0
STK3_ENST00000419617 STK3 Q13188 Serine/threonine-protein kinase 3 chr8 Not Cancer Driver No 1 hippie 70 241 32 32 0
TBL1X TBL1X O60907 F-box-like/WD repeat-containing protein TBL1X chrX Not Cancer Driver No 1 hippie 85 181 35 35 0
TMEM184A TMEM184A Q6ZMB5 Transmembrane protein 184A chr7 Not Cancer Driver No 1 intact, hippie 59 76 17 17 0
TNFSF12 TNFSF12 O43508 Tumor necrosis factor ligand superfamily member 12 chr17 Not Cancer Driver No 1 hippie 28 109 8 8 0
TP53_ENST00000445888 TP53 P04637 Cellular tumor antigen p53 chr17 Census, Compendium Yes 1 intact, hippie 2891 282 1466 1466 83
TRMT61B TRMT61B Q9BVS5 tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial chr2 Not Cancer Driver No 1 intact, hippie 48 123 10 10 0
TRUB2 TRUB2 O95900 Pseudouridylate synthase TRUB2, mitochondrial chr9 Not Cancer Driver No 1 hippie 37 73 7 7 0
TSN TSN Q15631 Translin chr2 Not Cancer Driver No 1 hippie 30 0 0 0 0
UACA UACA Q9BZF9 Uveal autoantigen with coiled-coil domains and ankyrin repeats chr15 Not Cancer Driver No 1 hippie 177 863 101 101 0
UIMC1_ENST00000511320 UIMC1 Q96RL1 BRCA1-A complex subunit RAP80 chr5 Not Cancer Driver No 1 hippie 64 609 51 51 0
XPO5 XPO5 Q9HAV4 Exportin-5 chr6 Not Cancer Driver No 1 hippie 112 64 7 7 0
ZNF707_ENST00000358656 ZNF707 Q96C28 Zinc finger protein 707 chr8 Not Cancer Driver No 2 intact, hippie 53 138 21 21 0
ZRANB1 ZRANB1 Q9UGI0 Ubiquitin thioesterase ZRANB1 chr10 Not Cancer Driver No 1 hippie 87 158 25 25 0